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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK1 203
CAMK CHEK2 220
CMGC MAPK14 24
TK NTRK1 510
CAMK NUAK1 55
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
CAMK STK11 49
CAMK TSSK1B 12
----W-DLVQTLGEGAYGEVQLAVNR-----VTEEAVAVKIVDMKRAVDCP-ENI-KK------EICINKMLNHENVVKFYGHRRE------GNIQYLFLEYCSGG--ELFDRIE-PDI----------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNL---KISDFGLATVFR---YNNRERLLNK---MCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y
---YI--MSKTLGSGACGEVKLAFER-----KTCKKVAIKIISKRKFAIGS-AREADPALNVETEIEILKKLNHPCIIKIKNFF-D------AEDYYIVLELMEGG--ELFDKVV-GNK----------------RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI------LGETSLMRT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL-
-----YQNLSPVGSGAYGSVCAAFDT-----KTGLRVAVKKLSRPFQSIIH-AKRTYR------ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA---DLNNIVK--CQ----------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL---KILDFGLAR--------HTDDEMTG---YVATRWYRAPEIML--NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-
---IV--LKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASE-SARQDFQ-R------EAELLTMLQHQHIVRFFGVCTE------GRPLLMVFEYMRHG--DLNRFLR--SHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVV---KIGDFGMSRDI--Y--S--TDYYRVGGRTMLPIRWMPPESIL---YRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACP------------------------------PEVYAIMRGCWQREPQQRHSIKDVHARL---
-----YELQETLGKGTYGKVKRATER-----FSGRVVAIKSIRKDKIKDEQ-DMVHIR-----REIEIMSSLNHPHIISIYEVFEN------KDKIVIIMEYASKG--ELYDYIS-ERR----------------RLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNI---KIADFGLSNL------YQKDKFLQT---FCGSPLYASPEIVN--GRPYRGPEVDSWALGVLLYTLVY-GTMPFDGF---DHKNLIRQISSGEYREPTQP-----------------------------SDARGLIRWMLMVNPDRRATIEDIANHWW-V
---PD----EVLGSGQFGIVYGGKHR-----KTGRDVAIKIIDKLRFPTKQ-ESQLRN------EVAILQNLHHPGVVNLECMFET------PERVFVVMEKLHGD--MLEMILSSEKG----------------RLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARI------IGEKSFRRS---VVGTPAYLAPEVLR---NKGYNRSLDMWSVGVIIYVSLS-GTFPFNED-----EDIHDQIQNAAFMYPPNPWKEIS------------------------HEAIDLINNLLQVKMRKRYSVDKTLSHPWL-
---PD----EVLGSGQFGVVYGGKHR-----KTGRDVAVKVIDKLRFPTKQ-ESQLRN------EVAILQSLRHPGIVNLECMFET------PEKVFVVMEKLHGD--MLEMILSSEKG----------------RLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARI------IGEKSFRRS---VVGTPAYLAPEVLL---NQGYNRSLDMWSVGVIMYVSLS-GTFPFNED-----EDINDQIQNAAFMYPASPWSHIS------------------------AGAIDLINNLLQVKMRKRYSVDKSLSHPWL-
--FAD----EVLGSGQFGIVYGGKHR-----KTGRDVAIKVIDKMRFPTKQ-ESQLRN------EVAILQNLHHPGIVNLECMFET------PERVFVVMEKLHGD--MLEMILSSEKS----------------RLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARI------IGEKSFRRS---VVGTPAYLAPEVLR---SKGYNRSLDMWSVGVIIYVSLS-GTFPFNED-----EDINDQIQNAAFMYPPNPWREIS------------------------GEAIDLINNLLQVKMRKRYSVDKSLSHPWL-
--YLM---GDLLGEGSYGKVKEVLDS-----ETLCRRAVKILKKKKLRRIP-NGEANVK----KEIQLLRRLRHKNVIQLVDVLYNE----EKQKMYMVMEYCVCGMQEMLDSVP--EK----------------RFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTL---KISDLGVAEALH---PFAADDTCRT---SQGSPAFQPPEIAN-GLDTFSGFKVDIWSAGVTLYNITT-GLYPFEGD---NIYKLFENIGKGSYAIPGDCG----------------------------PPLSDLLKGMLEYEPAKRFSIRQIRQHSWF-
YLLGI-----NLGEGSYAKVKSAYSE-----RLKFNVAIKIIDRKKAPADF-LEKFLP-----REIEILAMLNHCSIIKTYEIFET-----SHGKVYIVMELAVQG--DLLELIK-TRG----------------ALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNI---KLSDFSFSKRCLR-DDSGRMALSKT---FCGSPAYAAPEVLQ--GIPYQPKVYDIWSLGVILYIMVC-GSMPYDDS---NIKKMLRIQKEHRVNFPRSKHLT--------------------------GECKDLIYHMLQPDVNRRLHIDEILSHCWM-
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