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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK2 203
CAMK CHEK1 9
CMGC MAPK14 24
CMGC MAPK8 26
CAMK MAPKAPK2 64
Other NEK2 8
CAMK PIM1 38
CAMK PRKD1 583
TK SYK 371
TK TXK 271
-YI--MSKTLGSGACGEVKLAFER--KTCKKVAIKIISKRKFAIGS---AREADPALNVETEIEILKKL-NHPC--IIKIKNFF-D------AEDYYIVLELMEGG-ELFDKVV----GNK--RLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI----LGETSLM-RT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH---RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL--
--W-DLVQTLGEGAYGEVQLAVNR--VTEEAVAVKIVDMKRAVDCP---ENI-KK------EICINKML-NHEN--VVKFYGHRRE------GNIQYLFLEYCSGG-ELFDRIE----PDI--GMPEPDAQRFFHQLMAGVVYLHGI-----GITHRDIKPENLLLD-ERDNL---KISDFGLATVFR-YNNRERLL-NK---MCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP---SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y-
---YQNLSPVGSGAYGSVCAAFDT--KTGLRVAVKKLSRPFQSIIH---AKRTYR------ELRLLKHM-KHEN--VIGLLDVFTPARSLEEFNDVYLVTHLMGA--DLNNIVK-----CQ--KLTDDHVQFLIYQILRGLKYIHSA-----DIIHRDLKPSNLAVN-EDCEL---KILDFGLAR------HTDDEM-TG---YVATRWYRAPEIML--NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT-DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF--
---YQNLKPIGSGAQGIVCAAYDA--ILERNVAIKKLSRPFQNQTH---AKRAYR------ELVLMKCV-NHKN--IIGLLNVFTPQKSLEEFQDVYIVMELMDA--NLCQVIQ------M--ELDHERMSYLLYQMLCGIKHLHSA-----GIIHRDLKPSNIVVK-SDCTL---KILDFGLART----AGTSFMM-TP---YVVTRYYRAPEVIL---GMGYKENVDLWSVGCIMGEMVC-HKILFPGR-DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI--
KVT---SQVLGLGINGKVLQIFNK--RTQEKFALKMLQDCPKAR----------R------EVELHWRASQCPH--IVRIVDVYENLY--AGRKCLLIVMECLDGG-ELFSRIQD--RGDQ--AFTEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYT-SKRPNAILKLTDFGFAKE----TTSHNSL-TT---PCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS-----------------------------------EEVKMLIRNLLKTEPTQRMTITEFMNHPWI--
---YEVLYTIGTGSYGRCQKIRRK--SDGKILVWKELDYGSMTEAE---KQMLVS------EVNLLREL-KHPN--IVRYYDRIIDR----TNTTLYIVMEYCEGG-DLASVITKGTKERQ--YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNV---KLGDFGLARIL---NHDTSFA-KT---FVGTPYYMSPEQMN---RMSYNEKSDIWSLGCLLYELCA-LMPPFTAF----SQKELAGKIREGKFRRIPYRY---S-----------------------------------DELNEIITRMLNLKDYHRPSVEEILENPL-I-
---YQVGPLLGSGGFGSVYSGIRV--SDNLPVAIKHVEKDRISDWG---ELPNGTRV--PMEVVLLKKV-SSGFSGVIRLLDWFER------PDSFVLILERPEPVQDLFDFIT----ERG--ALQEELARSFFWQVLEAVRHCHNC-----GVLHRDIKDENILIDLNRGEL---KLIDFGSGA-----LLKDTVY-TD---FDGTRVYSPPEWIR--YHRYHGRSAAVWSLGILLYDMVC-GDIPFEHD----------EEIIRGQVFFRQRVS---------------------------------------SECQHLIRWCLALRPSDRPTFEEIQNHPWM--
-PD----EVLGSGQFGIVYGGKHR--KTGRDVAIKIIDKLRFPTKQ---ESQLRN------EVAILQNL-HHPG--VVNLECMFET------PERVFVVMEKLHGD-MLEMILS---SEKG--RLPEHITKFLITQILVALRHLHFK-----NIVHCDLKPENVLLA-SADPFPQVKLCDFGFARI----IGEKSFR-RS---VVGTPAYLAPEVLR---NKGYNRSLDMWSVGVIIYVSLS-GTFPFNED------EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------HEAIDLINNLLQVKMRKRYSVDKTLSHPWL--
TLE---DKELGSGNFGTVKKGYYQMKKVVKTVAVKILK-NEAN-DPALKDELL-A------EANVMQQL-DNPY--IVRMIGICE-------AESWMLVMEMAELG-PLNKYLQ-----QN-RHVKDKNIIELVHQVSMGMKYLEES-----NFVHRDLAARNVLLV-TQHYA---KISDFGLSKAL-R-A--DENYYKAQTHGKWPVKWYAPECIN---YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGM-KGSEVTAMLEKGERMGCPAGCP-----------------------------------------REMYDLMNLCWTYDVENRPGFAAVE----LRL
--L-AFIKEIGSGQFGVVHLGEWR---SHIQVAIKAIN-EGSM-SE---EDFI-E------EAKVMMKL-SHSK--LVQLYGVCIQ------RKPLYIVTEFMENG-CLLNYLR-----ENKGKLRKEMLLSVCQDICEGMEYLERN-----GYIHRDLAARNCLVS-STCIV---KISDFGMTRYV---L--DDEY-VSSFGAKFPIKWSPPEVFL---FNKYSSKSDVWSFGVLMWEVFTEGKMPFENK-SNLQVVEAISEGFRLYRPHLAP-----------------------------------------MSIYEVMYSCWHEKPEGRPTFAELLR---AV-
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