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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK2 203
CMGC CDC2 4
CMGC CDK2 4
CAMK CHEK1 9
CMGC CLK2 163
CMGC CLK3 156
CMGC DYRK1A 150
CMGC DYRK1B 111
TKL IRAK4 186
CAMK PIM1 38
TK SYK 371
TK TXK 271
-YI--MSKTLGSGACGEVKLAFER--KTCK-KVAIKIISKRKFAIGS---A-READPALNVETEIEILKKL-N-----HPC-----IIKIKNFF-DAEDYYIVLELMEGG-ELFDKVV---GNK--RL---KEATCKLYFYQMLLAVQYLHE--NGIIHRDLKPENVLLS--SQEEDC-----------------LIKITDFGHSKI----LGETSLM-RT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS---------------------------------------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL---
---YTKIEKIGEGTYGVVYKGRHK--TTGQ-VVAMKKIRLESEEEGV---P-STAIR------EISLLKEL-R-----HPN-----IVSLQDVLMQDSRLYLIFEFLSM--DLKKYLDSIPPGQ--YM---DSSLVKSYLYQILQGIVFCHS--RRVLHRDLKPQNLLID--DKGTI--------------------KLADFGLARAF---GIPIRVY-TH---EVVTLWYRSPEVLL--GSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF---
---FQKVEKIGEGTYGVVYKARNK--LTGE-VVALKKIRLDTETEGV---P-STAIR------EISLLKEL-N-----HPN-----IVKLLDVIHTENKLYLVFEFLHQ--DLKKFMDA-SALT--GI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN--TEGAI--------------------KLADFGLARAF---GVPVRTY-TH---EVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF---
--W-DLVQTLGEGAYGEVQLAVNR--VTEE-AVAVKIVDMKRAVDCP---E-NI-KK------EICINKML-N-----HEN-----VVKFYGHRREGNIQYLFLEYCSGG-ELFDRIE---PDI--GM---PEPDAQRFFHQLMAGVVYLHG--IGITHRDIKPENLLLD--ERDNL--------------------KISDFGLATVFR-YNNRERLL-NK---MCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D---------------------------------------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y--
---YEIVSTLGEGTFGRVVQCVDH--RRGGARVALKIIKNVEKYKEA---A-R---L------EINVLEKI-NEKDPDNKN----LCVQMFDWFDYHGHMCISFELLGL--STFDFLK---DNN--YLP-YPIHQVRHMAFQLCQAVKFLHD--NKLTHTDLKPENILFV--NSDYELTYNLEKKR-DERSVKSTAVRVVDFGSAT------FDHEHH-ST---IVSTRHYRAPEVIL---ELGWSQPCDVWSIGCIIFEYYV-GFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY--------------------VRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF---
---YEIVGNLGEGTFGKVVECLDH--ARGKSQVALKIIRNVGKYREA---A-R---L------EINVLKKI-KE--KDKENK--FLCVLMSDWFNFHGHMCIAFELLGK--NTFEFLK----EN--NFQPYPLPHVRHMAYQLCHALRFLHE--NQLTHTDLKPENILFV--NSE-FETLYNEHKSCEEKSVKNTSIRVADFGSAT------FDHEHH-TT---IVATRHYRPPEVIL---ELGWAQPCDVWSIGCILFEYYR-GFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRY--------------------VKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF---
---YEIDSLIGKGSFGQVVKAYDR--VEQE-WVAIKIIKNKKAFLNQ---A-QI---------EVRLLELMNK-----HDTEMKYYIVHLKRHFMFRNHLCLVFEMLSY--NLYDLLR----NT--NFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAI--------------------KIVDFGSSCQ------LGQRI-YQ---YIQSRFYRSPEVLL---GMPYDLAIDMWSLGCILVEMHT-GEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF---
---YEIDSLIGKGSFGQVVKAYDH--QTQE-LVAIKIIKNKKAFLNQ---A-QI---------ELRLLELMNQ-----HDTEMKYYIVHLKRHFMFRNHLCLVFELLSY--NLYDLLR----NT--HFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAI--------------------KIVDFGSSCQ------LGQRI-YQ---YIQSRFYRSPEVLL---GTPYDLAIDMWSLGCILVEMHT-GEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF---
VGG----NKMGEGGFGVVYKGYVN--NTT---VAVKKLAAMVDITTE---ELKQQFD-----QEIKVMAKC-Q-----HEN-----LVELLGFSSDGDDLCLVYVYMPNG-SLLDRLSCLDGTP--PL---SWHMRCKIAQGAANGINFLHE--NHHIHRDIKSANILLD--EAFTA--------------------KISDFGLARASE-KFAQTVMT-SR---IVGTTAYMAPEALR----GEITPKSDIYSFGVVLLEIIT-GLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDAD-------------------------------------------------STSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ
---YQVGPLLGSGGFGSVYSGIRV--SDNL-PVAIKHVEKDRISDWG---E-LPNGTRV--PMEVVLLKKV-S-----SGFS---GVIRLLDWFERPDSFVLILERPEPVQDLFDFIT---ERG--AL---QEELARSFFWQVLEAVRHCHN--CGVLHRDIKDENILID-LNRGEL--------------------KLIDFGSGA-----LLKDTVY-TD---FDGTRVYSPPEWIR--YHRYHGRSAAVWSLGILLYDMVC-GDIPFEHD---------EEIIRGQVFFRQRVS-------------------------------------------------------------SECQHLIRWCLALRPSDRPTFEEIQNHPWM---
TLE---DKELGSGNFGTVKKGYYQMKKVVK-TVAVKILK-NEAN-DPALKD-ELL-A------EANVMQQL-D-----NPY-----IVRMIGICE-AESWMLVMEMAELG-PLNKYLQ----QN-RHV---KDKNIIELVHQVSMGMKYLEE--SNFVHRDLAARNVLLV--TQHYA--------------------KISDFGLSKAL-R-A--DENYYKAQTHGKWPVKWYAPECIN---YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCP---------------------------------------------------------------REMYDLMNLCWTYDVENRPGFAAVE----LRL-
--L-AFIKEIGSGQFGVVHLGEWR---SHI-QVAIKAIN-EGSM-SE---E-DFI-E------EAKVMMKL-S-----HSK-----LVQLYGVCIQRKPLYIVTEFMENG-CLLNYLR----ENKGKL---RKEMLLSVCQDICEGMEYLER--NGYIHRDLAARNCLVS--STCIV--------------------KISDFGMTRYV---L--DDEY-VSSFGAKFPIKWSPPEVFL---FNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAP---------------------------------------------------------------MSIYEVMYSCWHEKPEGRPTFAELLR---AV--
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