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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK2 203
CMGC CDC2 4
CAMK CHEK1 9
CMGC MAPK14 24
TK TXK 271
YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFF-D------AEDYYIVLELMEGGELFDKVV---GNK--RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI---LGETSLMRT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL-
--YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR------EISLLKELRHPNIVSLQDVLMQ------DSRLYLIFEFLSM-DLKKYLDSIPPGQ--YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI---KLADFGLARAF--GIPIRVYTH---EVVTLWYRSPEVLL--GSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF-
-W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENI-KK------EICINKMLNHENVVKFYGHRRE------GNIQYLFLEYCSGGELFDRIE---PDI--GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNL---KISDFGLATVFRYNNRERLLNK---MCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y
--YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR------ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK----CQ--KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL---KILDFGLAR-----HTDDEMTG---YVATRWYRAPEIML--NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-
-L-AFIKEIGSGQFGVVHLGEWR-SHIQVAIKAIN-EGSM-SEEDFI-E------EAKVMMKLSHSKLVQLYGVCIQ------RKPLYIVTEFMENGCLLNYLR----ENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIV---KISDFGMTRYV--L--DDEYVSSFGAKFPIKWSPPEVFL---FNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAP------------------------------MSIYEVMYSCWHEKPEGRPTFAELLR---AV
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