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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CSNK2A1 203
CMGC CDK2 4
CMGC CDK9 2.7.11.23
CAMK DAPK1 13
AGC GRK6 186
CMGC GSK3B 56
CMGC MAPK10 64
CMGC MAPK12 27
AGC PDPK1 82
-YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR----------EIKILENLRGGPNIITLADIVKDP------VSRTPA--LVFEHVNNT--DFKQLY-------QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF-----YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAMEHPYF-----------
-FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPS-TAIR----EISLLKEL-NHPNIVKLLDVIHT--------ENKLY--LVFEFLHQ---DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-----------
-YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI-TALR----EIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVL----KLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQ-GNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK----------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF-----------
-YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRG-VSREDIEREVSILKEI-QHPNVITLHEVYEN--------KTDVI--LILELVAGG--ELFDFLA----EKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK-----IDFGNEFKNIFGTPEFVAPEIVN-YEPLGLEADMWSIGVITYILLSGASPFL-GD---TKQETLANVSAVNYEFEDEYFSNTS-----------------------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI-----------
F-RQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGE-AMAL---NEKQILEKV-NSRFVVSLAYAYET--------KDALC--LVLTLMNGG--DLKFHIYH--MGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD-DHGHI----RISDLGLAVH-----VPEGQTIKGRVGTVGYMAPEVVK-NERYTFSPDWWALGCLLYEMIAGQSPFQ-QRKKKIKREEVERLVK-EVPEEYSER--FS-----------------------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF-----------
-YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-----------ELQIMRKL-DHCNIVRLRYFFYSSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL----KLCDFGSAKQ-----LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFP-GDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF-----------
-YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAK-RAYR----ELVLMKCV-NHKNIISLLNVFTPQKT--LEEFQDVY--LVMELMDA---NLCQVIQ------MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL----KILDFGLART-----AGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFP-GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI-----------
-YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAK-RAYR----ELRLLKHM-RHENVIGLLDVFTPDET--LDDFTDFY--LVMPFMGT---DLGKLMK-----HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCEL----KILDFGLAR-------QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFK-GSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-----------KKDFASILTNASPLAVNLLEKMLVLDAEQRVT-----AGEALAHPYF-----------
F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTR----ERDVMSRL-DHPFFVKLYFTFQD--------DEKLY--FGLSYAKNG--ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI----QITDFGTAKVLS--PESKQARANSFVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVAGLPPFR-AG---NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
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