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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK DAPK1 203
Other AURKA 133
CMGC CDC2 4
CMGC CDK2 4
CAMK CHEK1 9
AGC GRK1 190
AGC GRK6 186
TK LCK 245
CMGC MAPK10 64
CMGC MAPK8 26
CMGC MAPK9 26
CAMK PIM1 38
CAMK PRKD1 583
CAMK STK33 116
----YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRR-TKSSRRGVSREDIEREVSILKEIQHPN--VITLHEVYEN------KTDVILILELVAGG-ELFDFLA----EKE---SLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLL-DRNVPKP-----RIKIIDFGLAHK---IDFGNEFKN---IFGTPEFVAPEIVN-YEPLGLEADMWSIGVITYILLS-GASPFLGD----TKQETLANVSAVNYEFEDEYFSNTS-----------------------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI------------
----FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR----EVEIQSHLRHPN--ILRLYGYFHD------ATRVYLILEYAPLG-TVYRELQ----KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL---------KIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN----TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI------------
----YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPSTAIR----EISLLKELRHPN--IVSLQDVLMQ------DSRLYLIFEFLSM--DLKKYLDS-IPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---------KLADFGLARAF--GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF------------
----FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIR----EISLLKELNHPN--IVKLLDVIHT------ENKLYLVFEFLHQ--DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---------KLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF------------
---W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR-AVDCPENI-KK----EICINKMLNHEN--VVKFYGHRRE------GNIQYLFLEYCSGG-ELFDRIE----PDI---GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---------KISDFGLATVFRYNNRERLLNK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELPWDQP---SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y-----------
FLDF----RVLGKGGFGEVSACQMKATGKLYACKKLNKKR-LKKRKGYQGAM---VEKKILMKVHSRF--IVSLAYAFET------KADLCLVMTIMNGG-DIRYHIYNVNEENP---GFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLD-NDGNV---------RISDLGLAVEL--LDGQSKTKG---YAGTPGFMAPELLQ-GEEYDFSVDYFALGVTLYEMIA-ARGPFRARGEKVENKELKHRIISEPVKYPDKFS---------------------------------------QASKDFCEALLEKDPEKRLG-----FRD-------ETCDKLRAHPLF
---F-RQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKR-IKKRKGEAMAL---NEKQILEKVNSRF--VVSLAYAYET------KDALCLVLTLMNGG-DLKFHIYH--MGQA---GFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD-DHGHI---------RISDLGLAVH---VPEGQTIKG---RVGTVGYMAPEVVK-NERYTFSPDWWALGCLLYEMIA-GQSPFQQR-KKKIKREEVERLVK-EVPEEYSER--FS-----------------------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF------------
----LKLVERLGAGQFGEVWMGYYN-GHTKVAVKSLK-QG-SM-SPDAFL-A----EANLMKQLQHQR--LVRLYAVVT-------QEPIYIITEYMENG-SLVDFLK-----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC---------KIADFGLARLI--E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L------------
----YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF-QNQTHAKRAYR----ELVLMKCVNHKN--IISLLNVFTPQKTLEEFQDVYLVMELMDA--NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---------KILDFGLART---AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFPGR-DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI------------
----YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPF-QNQTHAKRAYR----ELVLMKCVNHKN--IIGLLNVFTPQKSLEEFQDVYIVMELMDA--NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---------KILDFGLART---AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVC-HKILFPGR-DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VDEALQHPYI------------
----YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPF-QNQTHAKRAYR----ELVLLKCVNHKN--IISLLNVFTPQKTLEEFQDVYLVMELMDA--NLCQVIH------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---------KILDFGLART---ACTNFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVK-GCVIFQGT-DHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS-----VDEALRHPYI------------
----YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDR-ISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFER------PDSFVLILERPEPVQDLFDFIT----ERG---ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL---------KLIDFGSGA----LLKDTVYTD---FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHD----------EEIIRGQVFFRQRVS---------------------------------------SECQHLIRWCLALRPSDRPT-----FEEIQNHPWM------------
--PD----EVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLR-FPTKQESQLRN----EVAILQNLHHPG--VVNLECMFET------PERVFVVMEKLHGD-MLEMILS---SEKG---RLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLA-SADPFP------QVKLCDFGFARI---IGEKSFRRS---VVGTPAYLAPEVLR-NKGYNRSLDMWSVGVIIYVSLS-GTFPFNED------EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------HEAIDLINNLLQVKMRKRYS-----VDKTLSHPWL------------
----YTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEK-AGSSAVKLLER----EVNILKSVKHEH--IIHLEQVFET------PKKMYLVMELCEDG-ELKEILD----RKG---HFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVK-SSLIDDNNEINLNIKVTDFGLAVKK-QSRSEAMLQA---TCGTPIYMAPEVIS-AHDYSQQCDIWSIGVVMYMLLR-GEPPFLAS----SEEKLFELIRKGELHFENAVWNSIS-----------------------------------DCAKSVLKQLMKVDPAHRIT-----AKELLDNQWL------------
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