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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK DAPK1 203
TK ABL1 261
Other AURKA 133
Other CAMKK2 165
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
CMGC CDK9 2.7.11.23
CAMK CHEK1 9
CAMK CHEK2 220
CMGC CLK1 161
CMGC CLK4 159
TK JAK2 849
TK LCK 245
CMGC MAPK1 13
CAMK PIM1 38
Other TTK 525
--YDTGEELGSGQFAVVKKCREK----S-T-GLQYAAKFIKKRR-TKSSR--RGVSREDI---------------------EREVSILKEI-Q--HPN----VITLHEVYE--N--------KTDVILILELVAGG-ELFDFLA---EKE---SL--TEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLL-DRNVPKP---------------RIKIIDFGLAHK-------IDFGNEFKN---IFGTPEFVAPEIVN-----------YEP--LGLEADMWSIGVITYILLS-GASP---------------FLGD---TKQETLANVSAVNYEFEDEYFSNTS-------------------------------------ALAKDFIRRLLVKDPKKRMTIQDSLQHPWI--
--ITMKHKLGGGQYGEVYEGVWK----K-Y-SLTVAVKTLK-ED-TM-EV--EEFL-K-------------------------EAAVMKEI-K--HPN----LVQLLGVCT--R--------EPPFYIITEFMTYG-NLLDYLR----ECNRQEV--NAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLV-------------------KVADFGLSRLM------T--GDTYTAHAGAKFPIKWTAPESLA-----------YNK--FSIKSDVWAFGVLLWEIATYGMSP---------------YPGIDLSQVYELLEKDYRMERPEGCP-------------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F--
--FEIGRPLGKGKFGNVYLAREK----Q-S-KFILALKVLFKAQLEKAGV--EHQLRR-------------------------EVEIQSHL-R--HPN----ILRLYGYFH--D--------ATRVYLILEYAPLG-TVYRELQ---KLS---KF--DEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL-------------------KIADFGWSV--------HAPSSRRTT---LCGTLDYLPPEMIE-----------GRM--HDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN---TYQETYKRISRVEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
--YTLKDEIGKGSYGVVKLAYNE----N-D-NTYYAMKVLSKKK-LIRQA--GFPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL-D--HPN----VVKLVEVLD--DP------NEDHLYMVFELVNQG-PVMEVPT----LK---PL--SEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG-EDGHI-------------------KIADFGVSNEF------KGSDALLSN---TVGTPAFMAPESLS----------ETRKIFSGKALDVWAMGVTLYCFVF-GQCP---------------FMDE---RIMCLHSKIKSQALEFPDQPDIA---------------------------------------EDLKDLITRMLDKNPESRIVVPEIKLHPWV--
--YTKIEKIGEGTYGVVYKGRHK----T-T-GQVVAMKKIRLES-EEEGV--PSTAIR-------------------------EISLLKEL-R--HPN----IVSLQDVLM--Q--------DSRLYLIFEFLSM--DLKKYLDSIPPGQ---YM--DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI-------------------KLADFGLARAF------GIPIRVYTH---EVVTLWYRSPEVLL----------GSAR--YSTPVDIWSIGTIFAELAT-KKPL---------------FHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
--FQKVEKIGEGTYGVVYKARNK----L-T-GEVVALKKIRLDT-ETEGV--PSTAIR-------------------------EISLLKEL-N--HPN----IVKLLDVIH--T--------ENKLYLVFEFLHQ--DLKKFMDA-SALT---GI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI-------------------KLADFGLARAF------GVPVRTYTH---EVVTLWYRAPEILL----------GCKY--YSTAVDIWSLGCIFAEMVT-RRAL---------------FPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
--YEKLEKIGEGTYGTVFKAKNR----E-T-HEIVALKRVRLDD-DDEGV--PSSALR-------------------------EICLLKEL-K--HKN----IVRLHDVLH--S--------DKKLTLVFEFCDQ--DLKKYFD--SCNG---DL--DPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL-------------------KLADFGLARAF------GIPVRCYSA---EVVTLWYRPPDVLF----------GAKL--YSTSIDMWSAGCIFAELANAGRPL---------------FPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT---------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF--
--YEKLAKIGQGTFGEVFKARHR----K-T-GQKVALKKVLMEN-EKEGF--PITALR-------------------------EIKILQLL-K--HEN----VVNLIEICR--TKASPYNRCKGSIYLVFDFCEH--DLAGLLS--NVLV---KF--TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVL-------------------KLADFGLARAFSL--AKNSQPNRYTN---RVVTLWYRPPELLL----------GERD--YGPPIDLWGAGCIMAEMWT-RSPI---------------MQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF--
-W-DLVQTLGEGAYGEVQLAVNR----V-T-EEAVAVKIVDMKR-AVDCP--ENI-KK-------------------------EICINKML-N--HEN----VVKFYGHRR--E--------GNIQYLFLEYCSGG-ELFDRIE---PDI---GM--PEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL-------------------KISDFGLATVFR----YNNRERLLNK---MCGTLPYVAPELLK----------RREF--HAEPVDVWSCGIVLTAMLA-GELP---------------WDQP--SDSCQEYSDWKEKKTYLNPWKKI--D-------------------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y-
YI--MSKTLGSGACGEVKLAFER----K-T-CKKVAIKIISKRK-FAIGS--AREADPALN-------------------VETEIEILKKL-N--HPC----IIKIKNFF---D--------AEDYYIVLELMEGG-ELFDKVV---GNK---RL--KEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDC----------------LIKITDFGHSKI-------LGETSLMRT---LCGTPTYLAPEVLVS--------VGTAG--YNRAVDCWSLGVILFICLS-GYPP---------------FSEH--RTQVSLKDQITSGKYNFIPEVWAEVS-------------------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL--
--YEIVDTLGEGAFGKVVECIDH----K-AGGRHVAVKIVKNVD-RYCEA--ARS----------------------------EIQVLEHL-NTTDPNSTFRCVQMLEWFE--H--------HGHICIVFELLGL--STYDFIK---ENG---FLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFV-QSDYTEAYNPKIKRDERTLINPDIKVVDFGSA---------TYDDEHHST---LVSTRHYRAPEVIL-----------ALG--WSQPCDVWSIGCILIEYYL-GFTV---------------FPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF--
--YEIVDTLGEGAFGKVVECIDH----GMD-GMHVAVKIVKNVG-RYREA--ARS----------------------------EIQVLEHL-NSTDPNSVFRCVQMLEWFD--H--------HGHVCIVFELLGL--STYDFIK---ENS---FLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFV-KSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA---------TYDDEHHST---LVSTRHYRAPEVIL-----------ALG--WSQPCDVWSIGCILIEYYL-GFTV---------------FQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF--
--LKFLQQLGKGNFGSVEMCRYDPLQDN-T-GEVVAVKKLQ-HS-TE--EHLRDFE-R-------------------------EIEILKSL-Q--HDN----IVKYKGVCYSAG--------RRNLKLIMEYLPYG-SLRDYLQ----KH-KERI--DHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRV-------------------KIGDFGLTKVL--PQ--D--KEYYKVKEPGESPIFWYAPESLT-----------ESK--FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCP-------------------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
--LKLVERLGAGQFGEVWMGYYN------G-HTKVAVKSLK-QG-SM-SP--DAFL-A-------------------------EANLMKQL-Q--HQR----LVRLYAVVT-----------QEPIYIITEYMENG-SLVDFLK----TPSGIKL--TINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC-------------------KIADFGLARLI------E--DNEYTAREGAKFPIKWTAPEAIN-----------YGT--FTIKSDVWSFGILLTEIVTHGRIP---------------YPGMTNPEVIQNLERGYRMVRPDNCP-------------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--
--YTNLSYIGEGAYGMVCSAYDN----V-N-KVRVAIKKISPFE-HQTYC--QRT-LR-------------------------EIKILLRF-R--HEN----IIGINDIIR--APT---IEQMKDVYIVQDLMET--DLYKLLK----TQ---HL--SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDL-------------------KICDFGLARVAD---PDHDHTGFLTE---YVATRWYRAPEIML----------NSKG--YTKSIDIWSVGCILAEMLS-NRPI---------------FPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-------------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL--
--YQVGPLLGSGGFGSVYSGIRV----S-D-NLPVAIKHVEKDR-ISDWG--ELPNGTRV---------------------PMEVVLLKKV-S--SGFS--GVIRLLDWFE--R--------PDSFVLILERPEPVQDLFDFIT---ERG---AL--QEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL-------------------KLIDFGSGA--------LLKDTVYTD---FDGTRVYSPPEWIR----------YHRY--HGRSAAVWSLGILLYDMVC-GDIP---------------FEHD---------EEIIRGQVFFRQRVS-----------------------------------------SECQHLIRWCLALRPSDRPTFEEIQNHPWM--
--YSILKQIGSGGSSKVFQVLNE----K-K-Q-IYAIKYVNLEE-ADNQT--LDSYRN-------------------------EIAYLNKLQQ-HSDK----IIRLYDYEI--T--------DQYIYMVMECGNI--DLNSWLK---KKK---SI--DPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIV--DGML-------------------KLIDFGIANQMQ----PDTTSVVKDS---QVGTVNYMPPEAIKDMSSSRENGKSKSK--ISPKSDVWSLGCILYYMTY-GKTP---------------FQQI--INQISKLHAIIDPNHEIEFPDIPE---------------------------------------KDLQDVLKCCLKRDPKQRISIPELLAHPYV--
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