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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK DAPK3 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
TKL BRAF 456
CAMK BRSK1 50
CAMK BRSK2 19
CMGC CDK2 4
CAMK CHEK1 9
CAMK CHEK2 220
CAMK DAPK1 13
CAMK DAPK2 23
AGC GRK6 186
TK HCK 241
CMGC MAPK14 24
CAMK MARK2 53
CAMK MARK4 59
Other NEK1 4
CMGC NLK 126
CAMK NUAK1 55
AGC PDPK1 82
CAMK PHKG1 20
CAMK PIM1 38
CAMK PIM3 40
AGC PKN1 615
Other PLK1 53
Other PLK3 62
AGC PRKCA 339
AGC PRKCD 349
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA4 33
AGC RPS6KA6 73
CAMK STK17A 61
Other TBK1 9
CAMK TSSK1B 12
-----YEMGEELGSGQFAIV---RKCRQKGTGK---EYAAKFIKKR-R-LSSSR--RG-VSREEI---EREVNILREI-R----HPN--IITLHDIFEN------KTDVVLILELVSGG-ELFDFLA---EKE---SLTEDEATQFLKQILDGVHYLHS-KRIAHFDLKPENIM--LL-DKNVPNPRIKLIDFGIAHK------IEAGNEFKN---IFGTPEFVAPEIVN--------YEP---LGLEADMWSIGVITYILLS-GASPFLGE-------TKQETLTNISA----VNYDFDEEYFSNTS-------------------------ELAKDFIRRLLVKDPKRRMT-----IAQSLEHSWI------------------------------------------------------
-----FEIGRPLGKGKFGNV---YLAREKQSKF---ILALKVLFKA-QLEKAGV--EH-QLRR-------EVEIQSHL-R----HPN--ILRLYGYFHD------ATRVYLILEYAPLG-TVYRELQ---KLS---KFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLL--LG-SAGEL----KIADFGWSV-------HAPSSRRTT---LCGTLDYLPPEMIE--------GRM---HDEKVDLWSLGVLCYEFLV-GKPPFEAN-------TYQETYKRISR----VEFTFPDFVT-----------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI------------------------------------------------------
-----FEIGRPLGKGKFGNV---YLAREKKSHF---IVALKVLFKS-Q-IEKEG--VE-HQLR------REIEIQAHL-H----HPN--ILRLYNYFYD------RRRIYLILEYAPRG-ELYKELQ---KSC---TFDEQRTATIMEELADALMYCHG-KKVIHRDIKPENLL--LG-LKGEL----KIADFGWSV-------HAPSLRRKT---MCGTLDYLPPEMIE--------GRM---HNEKVDLWCIGVLCYELLV-GNPPFESA-------SHNETYRRIVK----VDLKFPASVP-----------------------------MGAQDLISKLLRHNPSERLP-----LAQVSAHPWV------------------------------------------------------
-----FEIGRPLGKGKFGNV---YLARLKESHF---IVALKVLFKS-Q-IEKEG--LE-HQLR------REIEIQAHL-Q----HPN--ILRLYNYFHD------ARRVYLILEYAPRG-ELYKELQ---KSE---KLDEQRTATIIEELADALTYCHD-KKVIHRDIKPENLL--LG-FRGEV----KIADFGWSV-------HTPSLRRKT---MCGTLDYLPPEMIE--------GRT---YDEKVDLWCIGVLCYELLV-GYPPFESA-------SHSETYRRILK----VDVRFPLSMP-----------------------------LGARDLISRLLRYQPLERLP-----LAQILKHPWV------------------------------------------------------
-----ITVGQRIGSGSFGTV---YKGKWH---G---DVAVKMLN-VTA-PT-PQQLQA-FK-N-------EVGVLRKT-R----HVN--ILLFMGYST-------KPQLAIVTQWCEGS-SLYHHLH----II-ETKFEMIKLIDIARQTAQGMDYLHA-KSIIHRDLKSNNIF--LH-EDLTV----KIGDFGLATVK--S--R--WSGSHQFEQLSGSILWMAPEVIR--------MQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNI-N--NRDQIIFMVGRGYLSPDLSKVRSNCP-------------------------------KAMKRLMAECLKKKRDERPL-----FPQILA---SI-----------------------------------------------------
-----YRLEKTLGKGQTGLV---KLGVHCITGQ---KVAIKIVNRE-K-LSESV--LM-KVER-------EIAILKLI-E----HPH--VLKLHDVYEN------KKYLYLVLEHVSGG-ELFDYLV---KKG---RLTPKEARKFFRQIVSALDFCHS-YSICHRDLKPENLL--LD-EKNNI----RIADFGMASL------QVGDSLLET---SCGSPHYACPEVIK-------GEKY---DGRRADMWSCGVILFALLV-GALPFDDD-------NLRQLLEKVKR----GVFHMPHFIP-----------------------------PDCQSLLRGMIEVEPEKRLS-----LEQIQKHPW-Y-----------------------------------------------------
-----YRLEKTLGKGQTGLV---KLGVHCVTCQ---KVAIKIVNRE-K-LSESV--LM-KVER-------EIAILKLI-E----HPH--VLKLHDVYEN------KKYLYLVLEHVSGG-ELFDYLV---KKG---RLTPKEARKFFRQIISALDFCHS-HSICHRDLKPENLL--LD-EKNNI----RIADFGMASL------QVGDSLLET---SCGSPHYACPEVIR-------GEKY---DGRKADVWSCGVILFALLV-GALPFDDD-------NLRQLLEKVKR----GVFHMPHFIP-----------------------------PDCQSLLRGMIEVDAARRLT-----LEHIQKHIW-Y-----------------------------------------------------
-----FQKVEKIGEGTYGVV---YKARNKLTGE---VVALKKIRLD-T-ETEGV--PS-TAIR-------EISLLKEL-N----HPN--IVKLLDVIHT------ENKLYLVFEFLHQ--DLKKFMDA-SALT---GIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLL--IN-TEGAI----KLADFGLARAF-----GVPVRTYTH---EVVTLWYRAPEILL-------GCKY---YSTAVDIWSLGCIFAEMVT-RRALFPGD----SEIDQLFRIFRTLG----TPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF------------------------------------------------------
----W-DLVQTLGEGAYGEV---QLAVNRVTEE---AVAVKIVDMK-R-AVDCP--EN-I-KK-------EICINKML-N----HEN--VVKFYGHRRE------GNIQYLFLEYCSGG-ELFDRIE---PDI---GMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL--LD-ERDNL----KISDFGLATVFR---YNNRERLLNK---MCGTLPYVAPELLK-------RREF---HAEPVDVWSCGIVLTAMLA-GELPWDQP------SDSCQEYSDWKE----KKTYLNPWKKI--D-------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y-----------------------------------------------------
---YI--MSKTLGSGACGEV---KLAFERKTCK---KVAIKIISKR-K-FAIGS--AR-EADPALN-VETEIEILKKL-N----HPC--IIKIKNFF-D------AEDYYIVLELMEGG-ELFDKVV---GNK---RLKEATCKLYFYQMLLAVQYLHE-NGIIHRDLKPENVL--LS-SQEEDC-LIKITDFGHSKI------LGETSLMRT---LCGTPTYLAPEVLVS-----VGTAG---YNRAVDCWSLGVILFICLS-GYPPFSEH------RTQVSLKDQITS----GKYNFIPEVWAEVS-------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL------------------------------------------------------
-----YDTGEELGSGQFAVV---KKCREKSTGL---QYAAKFIKKR-R-TKSSR--RG-VSREDI---EREVSILKEI-Q----HPN--VITLHEVYEN------KTDVILILELVAGG-ELFDFLA---EKE---SLTEEEATEFLKQILNGVYYLHS-LQIAHFDLKPENIM--LL-DRNVPKPRIKIIDFGLAHK------IDFGNEFKN---IFGTPEFVAPEIVN--------YEP---LGLEADMWSIGVITYILLS-GASPFLGD-------TKQETLANVSA----VNYEFEDEYFSNTS-------------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI------------------------------------------------------
-----YDIGEELGSGQFAIV---KKCREKSTGL---EYAAKFIKKR-Q-SRASR--RG-VSREEI---EREVSILRQV-L----HHN--VITLHDVYEN------RTDVVLILELVSGG-ELFDFLA---QKE---SLSEEEATSFIKQILDGVNYLHT-KKIAHFDLKPENIM--LL-DKNIPIPHIKLIDFGLAHE------IEDGVEFKN---IFGTPEFVAPEIVN--------YEP---LGLEADMWSIGVITYILLS-GASPFLGD-------TKQETLANITA----VSYDFDEEFFSQTS-------------------------ELAKDFIRKLLVKETRKRLT-----IQEALRHPWI------------------------------------------------------
----F-RQYRVLGKGGFGEV---CACQVRATGK---MYACKKLEKK-R-IKKRK--GE-AMAL------NEKQILEKV-N----SRF--VVSLAYAYET------KDALCLVLTLMNGG-DLKFHIYH-MGQA---GFPEARAVFYAAEICCGLEDLHR-ERIVYRDLKPENIL--LD-DHGHI----RISDLGLAVH------VPEGQTIKG---RVGTVGYMAPEVVK--------NER---YTFSPDWWALGCLLYEMIA-GQSPFQQR----KKKIKREEVERLVK-----EVPEEYSER--FS-------------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF------------------------------------------------------
-----LKLEKKLGAGQFGEV---WMATYN-KHT---KVAVKTMK-P-G-SM-SV--EA-FL-A-------EANVMKTL-Q----HDK--LVKLHAVVT-------KEPIYIITEFMAKG-SLLDFLK----SDEGSKQPLPKLIDFSAQIAEGMAFIEQ-RNYIHRDLRAANIL--VS-ASLVC----KIADFGLARVI-----E--DNEYTAREGAKFPIKWTAPEAIN--------FGS---FTIKSDVWSFGILLMEIVTYGRIPYPGM----SNPEVIRALERGYR----MPRPENCP-------------------------------EELYNIMMRCWKNRPEERPT-----FEYIQSV--L------------------------------------------------------
-----YQNLSPVGSGAYGSV---CAAFDTKTGL---RVAVKKLSRP-F-QSIIH--AK-RTYR-------ELRLLKHM-K----HEN--VIGLLDVFTPARSLEEFNDVYLVTHLMGA--DLNNIVK----CQ---KLTDDHVQFLIYQILRGLKYIHS-ADIIHRDLKPSNLA--VN-EDCEL----KILDFGLAR--------HTDDEMTG---YVATRWYRAPEIML-------NWMH---YNQTVDIWSVGCIMAELLT-GRTLFPGT----DHIDQLKLILRLVG----TPGAELLKKISSESARNYIQSLTQMP-KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF------------------------------------------------------
-----YRLLKTIGKGNFAKV---KLARHILTGK---EVAVKIIDKT-Q-LNSSS--LQ-KLFR-------EVRIMKVL-N----HPN--IVKLFEVIET------EKTLYLVMEYASGG-EVFDYLV---AHG---RMKEKEARAKFRQIVSAVQYCHQ-KFIVHRDLKAENLL--LD-ADMNI----KIADFGFSNE------FTFGNKLDT---FCGSPPYAAPELFQ-------GKKY---DGPEVDVWSLGVILYTLVS-GSLPFDGQ-------NLKELRERVLR----GKYRIPFYMS-----------------------------TDCENLLKKFLILNPSKRGT-----LEQIMKDRWM------------------------------------------------------
-----YRLLRTIGKGNFAKV---KLARHILTGR---EVAIKIIDKT-Q-LNPSS--LQ-KLFR-------EVRIMKGL-N----HPN--IVKLFEVIET------EKTLYLVMEYASAG-EVFDYLV---SHG---RMKEKEARAKFRQIVSAVHYCHQ-KNIVHRDLKAENLL--LD-AEANI----KIADFGFSNE------FTLGSKLDT---FCGSPPYAAPELFQ-------GKKY---DGPEVDIWSLGVILYTLVS-GSLPFDGH-------NLKELRERVLR----GKYRVPFYMS-----------------------------TDCESILRRFLVLNPAKRCT-----LEQIMKDKWI------------------------------------------------------
----Y-VRLQKIGEGSFGKA---ILVKSTEDGR---QYVIKEINIS-R-MSSKE--RE-ESRR-------EVAVLANM-K----HPN--IVQYRESFEE------NGSLYIVMDYCEGG-DLFKRINA-QKGV---LFQEDQILDWFVQICLALKHVHD-RKILHRDIKSQNIF--LT-KDGTV----QLGDFGIARVL-----NSTVELART---CIGTPYYLSPEICE--------NKP---YNNKSDIWALGCVLYELCT-LKHAFEAG-------SMKNLVLKIIS----GSFPPVSLHYS----------------------------YDLRSLVSQLFKRNPRDRPS-----VNSILEKGF-I-----------------------------------------------------
--IEP---DRPIGYGAFGVV---WSVTDPRDGK---RVALKKMPNV-F-QNLVS--CK-RVFR-------ELKMLCFF-K----HDN--VLSALDILQPPH-IDYFEEIYVVTELMQS--DLHKIIV---SPQ---PLSSDHVKVFLYQILRGLKYLHS-AGILHRDIKPGNLL--VN-SNCVL----KICDFGLARVE----ELDESRHMTQ---EVVTQYYRAPEILM-------GSRH---YSNAIDIWSVGCIFAELLG-RRILFQAQ----SPIQQLDLITDLLG----TPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRIS-----AKDALAHPYL------------------------------------------------------
-----YELQETLGKGTYGKV---KRATERFSGR---VVAIKSIRKD-K-IKDEQ--DM-VHIR------REIEIMSSL-N----HPH--IISIYEVFEN------KDKIVIIMEYASKG-ELYDYIS---ERR---RLSERETRHFFRQIVSAVHYCHK-NGVVHRDLKLENIL--LD-DNCNI----KIADFGLSNL------YQKDKFLQT---FCGSPLYASPEIVN-------GRPY---RGPEVDSWALGVLLYTLVY-GTMPFDGF-------DHKNLIRQISS----GEYREPTQP------------------------------SDARGLIRWMLMVNPDRRAT-----IEDIANHWW-V-----------------------------------------------------
----F-KFGKILGEGSFSTV---VLARELATSR---EYAIKILEKR-H-IIKEN--KVPYVTR-------ERDVMSRL-D----HPF--FVKLYFTFQD------DEKLYFGLSYAKNG-ELLKYIR---KIG---SFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENIL--LN-EDMHI----QITDFGTAKVLS---PESKQARANS---FVGTAQYVSPELLT--------EKS---ACKSSDLWALGCIIYQLVA-GLPPFRAG-------NEYLIFQKIIK----LEYDFPEKFF-----------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF-------------------------------------------
-----YEPKEILGRGVSSVV---RRCIHKPTSQ---EYAVKVIDVT-G-GGSFS--PE-EVRELREATLKEVDILRKVSG----HPN--IIQLKDTYET------NTFFFLVFDLMKRG-ELFDYLT---EKV---TLSEKETRKIMRALLEVICTLHK-LNIVHRDLKPENIL--LD-DNMNI----KLTDFGFSCQ------LEPGERLRE---VCGTPSYLAPEIIECS--MNEDHPG---YGKEVDMWSTGVIMYTLLA-GSPPFWHR-------KQMLMLRMIMS----GNYQFGSPEWDDYS-------------------------DTVKDLVSRFLVVQPQNRYT-----AEEALAHPFF------------------------------------------------------
-----YQVGPLLGSGGFGSV---YSGIRVSDNL---PVAIKHVEKD-R-ISDWG--EL-PNGTRV---PMEVVLLKKV-S----SGFSGVIRLLDWFER------PDSFVLILERPEPVQDLFDFIT---ERG---ALQEELARSFFWQVLEAVRHCHN-CGVLHRDIKDENIL--IDLNRGEL----KLIDFGSGA-------LLKDTVYTD---FDGTRVYSPPEWIR-------YHRY---HGRSAAVWSLGILLYDMVC-GDIPFEHD-------------EEIIR----GQVFFRQRVS-----------------------------SECQHLIRWCLALRPSDRPT-----FEEIQNHPWM------------------------------------------------------
-----YQVGAVLGSGGFGTV---YAGSRIADGL---PVAVKHVVKE-R-VTEWG--SL-GGATV----PLEVVLLRKV-GAAGGARG--VIRLLDWFER------PDGFLLVLERPEPAQDLFDFIT---ERG---ALDEPLARRFFAQVLAAVRHCHS-CGVVHRDIKDENLL--VDLRSGEL----KLIDFGSGA-------LLKDTVYTD---FDGTRVYSPPEWIR-------YHRY---HGRSATVWSLGVLLYDMVC-GDIPFEQD-------------EEILR----GRLLFRRRVS-----------------------------PECQQLIRWCLSLRPSERPS-----LDQIAAHPWM------------------------------------------------------
----F-KFLAVLGRGHFGKV---LLSEFRPSGE---LFAIKALKKG-D-IVARD--EV-ESLM------CEKRILAAV-TS-AGHPF--LVNLFGCFQT------PEHVCFVMEYSAGG-DLMLHIH----SD---VFSEPRAIFYSACVVLGLQFLHE-HKIVYRDLKLDNLL--LD-TEGYV----KIADFGLCKEG-----MGYGDRTST---FCGTPEFLAPEVLT--------DTS---YTRAVDWWGLGVLLYEMLV-GESPFPGD-------DEEEVFDSIVN----DEVRYPRFLS-----------------------------AEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFF------------------------------------------------------
---YV--RGRFLGKGGFAKC---FEISDADTKE---VFAGKIVPKS-L-LLKPH--QR-EKMS------MEISIHRSL-A----HQH--VVGFHGFFED------NDFVFVVLELCRRR-SLLELHK---RRK---ALTEPEARYYLRQIVLGCQYLHR-NRVIHRDLKLGNLF--LN-EDLEV----KIGDFGLATKV-----EYDGERKKT---LCGTPNYIAPEVLS--------KKG---HSFEVDVWSIGCIMYTLLV-GKPPFETS-------CLKETYLRIKK----NEYSIPKHIN-----------------------------PVAASLIQKMLQTDPTARPT-----INELLNDEFF------------------------------------------------------
---YL--KGRLLGKGGFARC---YEATDTETGS---AYAVKVIPQS-R-VAKPH--QR-EKIL------NEIELHRDL-Q----HRH--IVRFSHHFED------ADNIYIFLELCSRK-SLAHIWK---ARH---TLLEPEVRYYLRQILSGLKYLHQ-RGILHRDLKLGNFF--IT-ENMEL----KVGDFGLAARL-----EPPEQRKKT---ICGTPNYVAPEVLL--------RQG---HGPEADVWSLGCVMYTLLC-GSPPFETA-------DLKETYRCIKQ----VHYTLPASLS-----------------------------LPARQLLAAILRASPRDRPS-----IDQILRHDFF------------------------------------------------------
----F-NFLMVLGKGSFGKV---MLADRKGTEE---LYAIKILKKD-V-VIQDD--DV-ECTM------VEKRVLALLDK----PPF--LTQLHSCFQT------VDRLYFVMEYVNGG-DLMYHIQ---QVG---KFKEPQAVFYAAEISIGLFFLHK-RGIIYRDLKLDNVM--LD-SEGHI----KIADFGMCKEH-----MMDGVTTRT---FCGTPDYIAPEIIA--------YQP---YGKSVDWWAYGVLLYEMLA-GQPPFDGE-------DEDELFQSIME----HNVSYPKSLS-----------------------------KEAVSVCKGLMTKHPAKRLG-----C---------GPEGERDVREHAFF----------------------------------------
---FI--FHKVLGKGSFGKV---LLGELKGRGE---YFAIKALKKD-V-VLIDD--DV-ECTM------VEKRVLTLAAE----NPF--LTHLICTFQT------KDHLFFVMEFLNGG-DLMYHIQ---DKG---RFELYRATFYAAEIMCGLQFLHS-KGIIYRDLKLDNVL--LD-RDGHI----KIADFGMCKEN-----IFGESRAST---FCGTPDYIAPEILQ--------GLK---YTFSVDWWSFGVLLYEMLI-GQSPFHGD-------DEDELFESIRV----DTPHYPRWIT-----------------------------KESKDILEKLFEREPTKRLG----VTGNIKIHPFF------------------------------------------------------
---PD----EVLGSGQFGIV---YGGKHRKTGR---DVAIKIIDKL-R-FPTKQ--ES-QLRN-------EVAILQNL-H----HPG--VVNLECMFET------PERVFVVMEKLHGD-MLEMILS--SEKG---RLPEHITKFLITQILVALRHLHF-KNIVHCDLKPENVL--LA-SADPFP-QVKLCDFGFARI------IGEKSFRRS---VVGTPAYLAPEVLR--------NKG---YNRSLDMWSVGVIIYVSLS-GTFPFNED---------EDIHDQIQN----AAFMYPPNPWKEIS-------------------------HEAIDLINNLLQVKMRKRYS-----VDKTLSHPWL------------------------------------------------------
---PD----EVLGSGQFGVV---YGGKHRKTGR---DVAVKVIDKL-R-FPTKQ--ES-QLRN-------EVAILQSL-R----HPG--IVNLECMFET------PEKVFVVMEKLHGD-MLEMILS--SEKG---RLPERLTKFLITQILVALRHLHF-KNIVHCDLKPENVL--LA-SADPFP-QVKLCDFGFARI------IGEKSFRRS---VVGTPAYLAPEVLL--------NQG---YNRSLDMWSVGVIMYVSLS-GTFPFNED---------EDINDQIQN----AAFMYPASPWSHIS-------------------------AGAIDLINNLLQVKMRKRYS-----VDKSLSHPWL------------------------------------------------------
--FAD----EVLGSGQFGIV---YGGKHRKTGR---DVAIKVIDKM-R-FPTKQ--ES-QLRN-------EVAILQNL-H----HPG--IVNLECMFET------PERVFVVMEKLHGD-MLEMILS--SEKS---RLPERITKFMVTQILVALRNLHF-KNIVHCDLKPENVL--LA-SAEPFP-QVKLCDFGFARI------IGEKSFRRS---VVGTPAYLAPEVLR--------SKG---YNRSLDMWSVGVIIYVSLS-GTFPFNED---------EDINDQIQN----AAFMYPPNPWREIS-------------------------GEAIDLINNLLQVKMRKRYS-----VDKSLSHPWL------------------------------------------------------
-----FELLKVLGQGSFGKVFLVRKVTRPDSGH---LYAMKVLKKA-T-LKVRD--RV-RTKM-------ERDILADV-N----HPF--VVKLHYAFQT------EGKLYLILDFLRGG-DLFTRLS---KEV---MFTEEDVKFYLAELALGLDHLHS-LGIIYRDLKPENIL--LD-EEGHI----KLTDFGLSKEA-----IDHEKKAYS---FCGTVEYMAPEVVN--------RQG---HSHSADWWSYGVLMFEMLT-GSLPFQGK-------DRKETMTLILK----AKLGMPQFLS-----------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY----------------------------------------------------
-----FELLKVLGQGSYGKV---FLVRKVKGSDAGQLYAMKVLKKA-T-LKVRD--RV-RSKM-------ERDILAEV-N----HPF--IVKLHYAFQT------EGKLYLILDFLRGG-DLFTRLS---KEV---MFTEEDVKFYLAELALALDHLHS-LGIIYRDLKPENIL--LD-EEGHI----KITDFGLSKEA-----IDHDKRAYS---FCGTIEYMAPEVVN--------RRG---HTQSADWWSFGVLMFEMLT-GSLPFQGK-------DRKETMALILK----AKLGMPQFLS-----------------------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF------------------------------------------------------
-----FELLKVLGQGSFGKV---FLVKKISGSDARQLYAMKVLKKA-T-LKVRD--RV-RTKM-------ERDILVEV-N----HPF--IVKLHYAFQT------EGKLYLILDFLRGG-DLFTRLS---KEV---MFTEEDVKFYLAELALALDHLHS-LGIIYRDLKPENIL--LD-EEGHI----KLTDFGLSKES-----IDHEKKAYS---FCGTVEYMAPEVVN--------RRG---HTQSADWWSFGVLMFEMLT-GTLPFQGK-------DRKETMTMILK----AKLGMPQFLS-----------------------------PEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF------------------------------------------------------
--REP-----ALGQGSFSVC---RRCRQRQSGQ---EFAVKILSRR-L-EANTQ--R-------------EVAALRLCQS----HPN--VVNLHEVHHD------QLHTYLVLELLRGG-ELLEHIR---KKR---HFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENIL--YA-DDT-PGAPVKIIDFGFARLR----PQSPGVPMQT---PCFTLQYAAPELLA--------QQG---YDESCDLWSLGVILYMMLS-GQVPFQGASGQGGQSQAAEIMCKIRE----GRFSLDGEAWQGVS-------------------------EEAKELVRGLLTVDPAKRLK-----LEGLRGSSW-L-----------------------------------------------------
-----FELLKVLGQGSFGKV---FLVRKKTGPDAGQLYAMKVLKKA-S-LKVRD--RV-RTKM-------ERDILVEV-N----HPF--IVKLHYAFQT------EGKLYLILDFLRGG-DVFTRLS---KEV---LFTEEDVKFYLAELALALDHLHQ-LGIVYRDLKPENIL--LD-EIGHI----KLTDFGLSKES-----VDQEKKAYS---FCGTVEYMAPEVVN--------RRG---HSQSADWWSYGVLMFEMLT-GTLPFQGK-------DRNETMNMILK----AKLGMPQFLS-----------------------------AEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF------------------------------------------------------
--LCP---GRELGRGKFAVV---RKCIKKDSGK---EFAAKFMRKR-R-KGQDC--RM-EIIH-------EIAVLELAQD----NPW--VINLHEVYET------ASEMILVLEYAAGG-EIFDQCVA-DREE---AFKEKDVQRLMRQILEGVHFLHT-RDVVHLDLKPQNIL--LT-SESPLG-DIKIVDFGLSRI------LKNSEELRE---IMGTPEYVAPEILS--------YDP---ISMATDMWSIGVLTYVMLT-GISPFLGN-------DKQETFLNISQ----MNLSYSEEEFDVLS-------------------------ESAVDFIRTLLVKKPEDRAT-----AEECLKHPWL------------------------------------------------------
--WLL---SDILGQGATANV---FRGRHKKTGD---LFAIKVFNNI-S-FLRPV--DV-Q-MR-------EFEVLKKL-N----HKN--IVKLFAIEEET----TTRHKVLIMEFCPCG-SLYTVLEEPSNAY---GLPESEFLIVLRDVVGGMNHLRE-NGIVHRDIKPGNIMRVIG-EDGQSV--YKLTDFGAARE------LEDDEQFVS---LYGTEEYLHPDMYERAVLRKDHQKK---YGATVDLWSIGVTFYHAAT-GSLPFRPF---EGPRRNKEVMYKIIT----GKPSGAISGVQKAENGPIDWSGDM----PVSCSLSRGLQV----------------------------------LLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSY
YLLGI-----NLGEGSYAKV---KSAYSERLKF---NVAIKIIDRK-K-APADF--LE-KFLP------REIEILAML-N----HCS--IIKTYEIFET-----SHGKVYIVMELAVQG-DLLELIK---TRG---ALHEDEARKKFHQLSLAIKYCHD-LDVVHRDLKCDNLL--LD-KDFNI----KLSDFSFSKRCLR-DDSGRMALSKT---FCGSPAYAAPEVLQ-------GIPY---QPKVYDIWSLGVILYIMVC-GSMPYDDS-------NIKKMLRIQKE----HRVNFPRSKHLT---------------------------GECKDLIYHMLQPDVNRRLH-----IDEILSHCWM------------------------------------------------------
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