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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK DDR1 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
TK BLK 241
TKL BRAF 456
TK CSF1R 582
TK EGFR 712
TK EPHA8 635
TK ERBB4 718
TK FGFR1 478
TK FGR 263
TK FRK 234
TK FYN 271
TK HCK 241
TK INSR 1023
TK ITK 363
TK JAK2 849
TK JAK3 822
TK KIT 589
TK LCK 245
TK LYN 247
TK PDGFRA 593
TK PDGFRB 600
AGC PRKCA 339
TK RET 724
TK SRC 270
CAMK STK17A 61
TK SYK 371
TK TYK2 589
TK YES1 277
---LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR-P-DAT-KNA-RNDFL-K-EVKIMSRL--KDPNIIRLLGVCV--QDDPLCMITDYMENGDLNQFLS---AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGE---NFTI---KIADFGMSRNL--YA--GDYY-RVQGRAVLPIRWMAWECILMGK---FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL-TDEQVIENAGEFFRDQGRQ-VYLSRPPACP------QGLYE-LMLRCWSRESEQRPPFSQLHRFL----------------
---ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTLK-E-DTM-EV---EEFL-K-EAAVMKEI--KHPNLVQLLGVCT--REPPFYIITEFMTYGNLLDYLR---EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLV---KVADFGLSRLM---T--GDTY-TAHAGAKFPIKWTAPESLAYNK---FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQVYELL----EKDYR----MERPEGCP------EKVYE-LMRACWQWNPSDRPSFAEIHQA--F--------------
---ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTLK-E-DTM-EV---EEFL-K-EAAVMKEI--KHPNLVQLLGVCT--LEPPFYIVTEYMPYGNLLDYLR---EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHVV---KVADFGLSRLM---T--GDTY-TAHAGAKFPIKWTAPESLAYNT---FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQVYDLL----EKGYR----MEQPEGCP------PKVYE-LMRACWKWSPADRPSFAETHQA--F--------------
--I-TLIRGLGHGAFGEVYEGQVSG-----------MPNDPSPLQVAVKTLP-E-VCS-EQD-ELDFL-M-EALIISKF--NHQNIVRCIGVSL--QSLPRFILLELMAGGDLKSFLR---ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVA---KIGDFGMARDI--YR--ASYY-RKGGCAMLPVKWMPPEAFMEGI---FTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK-SNQEVLEFV----TSGGR----MDPPKNCP------GPVYR-IMTQCWQHQPEDRPNFAIILER--I--------------
--L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAIKTLK-E-GTM-SP---EAFL-G-EANVMKAL--QHERLVRLYAVVT---KEPIYIVTEYMARGCLLDFLK---TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSE---ALCC---KIADFGLARII------DSEY-TAQEGAKFPIKWTAPEAIHFGV---FTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM-SNPEVIRNL----ERGYR----MPRPDTCP------PELYRGVIAECWRSRPEERPTFEFLQSV--L--------------
---ITVGQRIGSGSFGTVYKGKWH-------------------GDVAVKMLN-VTAPT-PQQ-LQAFK-N-EVGVLRKT--RHVNILLFMGYST---KPQLAIVTQWCEGSSLYHHLH---II--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHE---DLTV---KIGDFGLATVK--SR--WSGS-HQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQ-LP---------------YSNINNRDQIIFMV----GRGYLSPDLSKVRSNCP------KAMKR-LMAECLKKKRDERPLFPQILA---SI-------------
---LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAVKMLK-S-TAH-ADE-KEALM-S-ELKIMSHLG-QHENIVNLLGACT--HGGPVLVITEYCCYGDLLNFLR---RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN---GHVA---KIGDFGLARDI--MN--DSNY-IVKGNARLPVKWMAPESIFDCV---YTVQSDVWSYGILLWEIFSLGL-NP---------------YPGILVNSKFYKLV----KDGYQ----MAQPAFAP------KNIYS-IMQACWALEPTHRPTFQQICSFL----------------
--F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKIPVAIKELR-E-ATS-PKA-NKEIL-D-EAYVMASV--DNPHVCRLLGICL---TSTVQLITQLMPFGCLLDYVR---EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHV---KITDFGLAKLL--GA--EEKE-YHAEGGKVPIKWMALESILHRI---YTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI-PASEISSIL----EKGER----LPQPPICT------IDVYM-IMVKCWMIDADSRPKFRELI----IEF------------
---IHIEKIIGSGDSGEVCYGRLR-------------VPGQRDVPVAIKALK-A-GYT-ERQ-RRDFL-S-EASIMGQF--DHPNIIRLEGVVT--RGRLAMIVTEYMENGSLDTFLR---TH--------------------------------------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDS---NLVC---KVSDFGLSRVL--ED--DPDAAYTTTGGKIPIRWTAPEAIAFRT---FSSASDVWSFGVVMWEVLAYGE-RP---------------YWNM-TNRDVISSV----EEGYR----LPAPMGCP------HALHQ-LMLDCWHKDRAQRPRFSQIVSVL----------------
--L-KRVKVLGSGAFGTVYKGIWVP------------EGETVKIPVAIKILN-E-TTG-PKA-NVEFM-D-EALIMASM--DHPHLVRLLGVCL---SPTIQLVTQLMPHGCLLEYVH---EH--------------------------------------------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKS---PNHV---KITDFGLARLL--EG--DEKE-YNADGGKMPIKWMALECIHYRK---FTHQSDVWSYGVTIWELMTFGG-KP---------------YDGI-PTREIPDLL----EKGER----LPQPPICT------IDVYM-VMVKCWMIDADSRPKFKELAAE--F--------------
--L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKMLK-S-DAT-EKD-LSDLI-S-EMEMMKMIG-KHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLQ---ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVM---KIADFGLARDI--HH--IDYY-KKTTNGRLPVKWMAPEALFDRI---YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV-PVEELFKLL----KEGHR----MDKPSNCT------NELYM-MMRDCWHAVPSQRPTFKQLVEDL----------------
---ITLERRLGTGCFGDVWLGTWN-----------------GSTKVAVKTLK-P-GTM-SP---KAFL-E-EAQVMKLL--RHDKLVQLYAVVS---EEPIYIVTEFMCHGSLLDFLK---NP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGE---RLAC---KIADFGLARLI---K--DDEY-NPCQGSKFPIKWTAPEAALFGR---FTIKSDVWSFGILLTELITKGR-IP---------------YPGM-NKREVLEQV----EQGYH----MPCPPGCP------ASLYE-AMEQTWRLDPEERPTFEYLQSFL----------------
---IQLLKRLGSGQFGEVWEGLWN-----------------NTTPVAVKTLK-P-GSM-DP---NDFL-R-EAQIMKNL--RHPKLIQLYAVCT--LEDPIYIITELMRHGSLQEYLQ---ND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGE---HNIY---KVADFGLARVFKVDN--EDIY-ESRHEIKLPVKWTAPEAIRSNK---FSIKSDVWSFGILLYEIITYGK-MP---------------YSGM-TGAQVIQML----AQNYR----LPQPSNCP------QQFYN-IMLECWNAEPKERPTFETLRWK--L--------------
---LQLIKRLGNGQFGEVWMGTWN-----------------GNTKVAIKTLK-P-GTM-SP---ESFL-E-EAQIMKKL--KHDKLVQLYAVVS---EEPIYIVTEYMNKGSLLDFLK---DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGN---GLIC---KIADFGLARLI---E--DNEY-TARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILLTELVTKGR-VP---------------YPGM-NNREVLEQV----ERGYR----MPCPQDCP------ISLHE-LMIHCWKKDPEERPTFEYLQSFL----------------
---LKLEKKLGAGQFGEVWMATYN-----------------KHTKVAVKTMK-P-GSM-SV---EAFL-A-EANVMKTL--QHDKLVKLHAVVT---KEPIYIITEFMAKGSLLDFLK---SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA---SLVC---KIADFGLARVI---E--DNEY-TAREGAKFPIKWTAPEAINFGS---FTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM-SNPEVIRAL----ERGYR----MPRPENCP------EELYN-IMMRCWKNRPEERPTFEYIQSV--L--------------
---ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAVKTVN-E-SAS-LRE-RIEFL-N-EASVMKGF--TCHHVVRLLGVVS--KGQPTLVVMELMAHGDLKSYLR---SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTV---KIGDFGMTRDI--YE--TDYY-RKGGKGLLPVRWMAPESLKDGV---FTTSSDMWSFGVVLWEITSLAE-QP---------------YQGL-SNEQVLKFV----MDGGY----LDQPDNCP------ERVTD-LMRMCWQFNPKMRPTFLEIVNLL----------------
---LTFVQEIGSGQFGLVHLGYWL-----------------NKDKVAIKTIR-E-GAM-SE---EDFI-E-EAEVMMKL--SHPKLVQLYGVCL--EQAPICLVFEFMEHGCLSDYLR---TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGE---NQVI---KVSDFGMTRFV---L--DDQY-TSSTGTKFPVKWASPEVFSFSR---YSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR-SNSEVVEDI----STGFR----LYKPRLAS------THVYQ-IMNHCWKERPEDRPAFSRLLRQL----------------
---LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAVKKLQ-H-STE--EH-LRDFE-R-EIEILKSL--QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ---KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN---ENRV---KIGDFGLTKVL-PQD--KEYY-KVKEPGESPIFWYAPESLTESK---FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM-IVFHLIELL----KNNGR----LPRPDGCP------DEIYM-IMTECWNNNVNQRPSFRDLA----LRV------------
--L-KYISQLGKGNFGSVELCRYDP------------LGDNTGALVAVKQLQ-H-SGP-DQ--QRDFQ-R-EIQILKAL--HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ---RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVES---EAHV---KIADFGLAKLL-PLD--KDYY-VVREPGQSPIFWYAPESLSDNI---FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDVPALCRLLELL----EEGQR----LPAPPACP------AEVHE-LMKLCWAPSPQDRPSFSALGP---QL-------------
---LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAVKMLK-P-SAH-LTE-REALM-S-ELKVLSYLG-NHMNIVNLLGACT--IGGPTLVITEYCCYGDLLNFLR---RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH---GRIT---KICDFGLARDI--KN--DSNY-VVKGNARLPVKWMAPESIFNCV---YTFESDVWSYGIFLWELFSLGS-SP---------------YPGMPVDSKFYKMI----KEGFR----MLSPEHAP------AEMYD-IMKTCWDADPLKRPTFKQIVQL--I--------------
---LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSLK-Q-GSM-SP---DAFL-A-EANLMKQL--QHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLK---TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSC---KIADFGLARLI---E--DNEY-TAREGAKFPIKWTAPEAINYGT---FTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM-TNPEVIQNL----ERGYR----MVRPDNCP------EELYQ-LMRLCWKERPEDRPTFDYLRSV--L--------------
---IKLVKRLGAGQFGEVWMGYYN-----------------NSTKVAVKTLK-P-GTM-SV---QAFL-E-EANLMKTL--QHDKLVRLYAVVT--REEPIYIITEYMAKGSLLDFLK---SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSE---SLMC---KIADFGLARVI---E--DNEY-TAREGAKFPIKWTAPEAINFGC---FTIKSDVWSFGILLYEIVTYGK-IP---------------YPGR-TNADVMTAL----SQGYR----MPRVENCP------DELYD-IMKMCWKEKAEERPTFDYLQSV--L--------------
--L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAVKMLK-P-TAR-SSE-KQALM-S-ELKIMTHLG-PHLNIVNLLGACT--KSGPIYIITEYCFYGDLVNYLH---KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQ---GKIV---KICDFGLARDI--MH--DSNY-VSKGSTFLPVKWMAPESIFDNL---YTTLSDVWSYGILLWEIFSLGG-TP---------------YPGMMVDSTFYNKI----KSGYR----MAKPDHAT------SEVYE-IMVKCWNSEPEKRPSFYHLSE---IV-------------
--L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAVKMLK-S-TAR-SSE-KQALM-S-ELKIMSHLG-PHLNVVNLLGACT--KGGPIYIITEYCRYGDLVDYLH---RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICE---GKLV---KICDFGLARDI--MR--DSNY-ISKGSTFLPLKWMAPESIFNSL---YTTLSDVWSFGILLWEIFTLGG-TP---------------YPELPMNEQFYNAI----KRGYR----MAQPAHAS------DEIYE-IMQKCWEEKFEIRPPFSQLVL---LL-------------
--F-NFLMVLGKGSFGKVMLADRK----------------GTEELYAIKILKKD-VVIQDD---DVECTMVEKRVLALL-DKPPFLTQLHSCFQ--TVDRLYFVMEYVNGGDLMYHIQ--QVG----------------------------------------------------------------------------------------------------KFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDS---EGHI---KIADFGMCKEH---MMDGVTT-RT---FCGTPDYIAPEIIAYQP---YGKSVDWWAYGVLLYEMLA-GQ-PP---------------FDGE----DEDELF----QSIME----HNVSYPKSLS----KEAVS-VCKGLMTKHPAKRLGC---------GPEGERDVREHAFF
--L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYTTVAVKMLK-E-NAS-PSE-LRDLL-S-EFNVLKQV--NHPHVIKLYGACS--QDGPLLLIVEYAKYGSLRGFLR---ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKM---KISDFGLSRDV--YE--EDSY-VKRSQGRIPVKWMAIESLFDHI---YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI-PPERLFNLL----KTGHR----MERPDNCS------EEMYR-LMLQCWKQEPDKRPVFADISKDL----------------
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAIKTLK-P-GTM-SP---EAFL-Q-EAQVMKKL--RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLK---GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVC---KVADFGLARLI---E--DNEY-TARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM-VNREVLDQV----ERGYR----MPCPPECP------ESLHD-LMCQCWRKEPEERPTFEYLQAF--L--------------
LCP---GRELGRGKFAVVRKCIKK----------------DSGKEFAAKFMRKR-RKGQDC---RMEIIH-EIAVLELA-QDNPWVINLHEVYE--TASEMILVLEYAAGGEIFDQCVADREE----------------------------------------------------------------------------------------------------AFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTS---ESPLGDIKIVDFGLSRI----LKNSEEL-RE---IMGTPEYVAPEILSYDP---ISMATDMWSIGVLTYVMLT-GI-SP---------------FLGN----DKQETF----LNISQ----MNLSYSEEEFDVLSESAVD-FIRTLLVKKPEDRATAEECLKHPWL--------------
TLE---DKELGSGNFGTVKKGYYQ--------------MKKVVKTVAVKILK-N-EAN-DPALKDELL-A-EANVMQQL--DNPYIVRMIGICE---AESWMLVMEMAELGPLNKYLQ---QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT---QHYA---KISDFGLSKAL--RA--DENYYKAQTHGKWPVKWYAPECINYYK---FSSKSDVWSFGVLMWEAFSYGQ-KP---------------YRGM-KGSEVTAML----EKGER----MGCPAGCP------REMYD-LMNLCWTYDVENRPGFAAVE----LRL------------
--L-KKIRDLGEGHFGKVSLYCYDP------------TNDGTGEMVAVKALK-A-DCG-PQH-RSGWK-Q-EIDILRTL--YHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLP---RH----------------------------------------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDN---DRLV---KIGDFGLAKAV-PEG--HEYY-RVREDGDSPVFWYAPECLKEYK---FYYASDVWSFGVTLYELLTHCD-SSQSPPTKF-LELIGIAQGQM-TVLRLTELL----ERGER----LPRPDKCP------CEVYH-LMKNCWETEASFRPTFENLIP---IL-------------
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAIKTLK-P-GTM-MP---EAFL-Q-EAQIMKKL--RHDKLVPLYAVVS---EEPIYIVTEFMSKGSLLDFLK---EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGE---NLVC---KIADFGLARLI---E--DNEY-TARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM-VNREVLEQV----ERGYR----MPCPQGCP------ESLHE-LMNLCWKKDPDERPTFEYIQSFL----------------
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