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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK DDR1 203
TK ABL1 261
TKL BRAF 456
TK EPHA3 621
TK FLT1 827
TK FLT4 845
TK KDR 834
TK KIT 589
TK MET 1078
TK MUSK 575
TK NTRK2 538
TK NTRK3 538
TK PDGFRA 593
TK PDGFRB 600
TKL RIPK1 17
TK TEK 824
TK TIE1 839
---LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL-RP-DATKNARNDFLKEVKIMSRL-KDPNIIRLLGVCV-QDDPLCMITDYMENGDLNQFLSAHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNL-------YAGDYY--------------RVQGRAVLPIRWMAWECILMGK---FTTASDVWAFGVTLWEVLMLCRAQPFGQL-TDEQVIENAGEFFRDQGRQ-VYLS---RPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL--
---ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTL-KE-DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-REPPFYIITEFMTYGNLLDYLREC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--------TGDTY--------------TAHAGAKFPIKWTAPESLAYNK---FSIKSDVWAFGVLLWEIATYGM-SPYPGI-DLSQVYELL----EKDYR----ME---RPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F-
---ITVGQRIGSGSFGTVYKGKWH-------------------GDVAVKML-NVTAPTPQQLQAFKNEVGVLRKT-RHVNILLFMGYST--KPQLAIVTQWCEGSSLYHHLHII--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK-------SRWSGS--------------HQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQ-LPYSNINNRDQIIFMV----GRGYLSPDLSK---VRSNCPKAMKRLMAECLKKKRDERPLFPQILA--SI
--I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEISVAIKTL-KV-GYTEKQRRDFLGEASIMGQF-DHPNIIRLEGVVT-KSKPVMIVTEYMENGSLDSFLRKH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVL-------EDDPEA-------------AYTTRGGKIPIRWTSPEAIAYRK---FTSASDVWSYGIVLWEVMSYGE-RPYWEM-SNQDVIKAV----DEGYR----LP---PPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSIL--
---LKLGKSLGRGAFGKVVQASAFG-----------IKKSPTCRTVAVKML-KE-GATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPR--------------------------------LDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDI-------YKNPDY--------------VRKGDTRLPLKWMAPESIFDKI---YSTKSDVWSYGVLLWEIFSLGG-SPYPGVQMDEDFCSRL----REGMR----MR---APEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL--
---LHLGRVLGYGAFGKVVEASAFG-----------IHKGSSCDTVAVKML-KE-GATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDI-------YKDPDY--------------VRKGSARLPLKWMAPESIFDKV---YTTQSDVWSFGVLLWEIFSLGA-SPYPGVQINEEFCQRL----RDGTR----MR---APELATPAIRRIMLNCWSGDPKARPAFSELVEIL--
---LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAVKML-KE-GATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI-------YKDPDY--------------VRKGDARLPLKWMAPETIFDRV---YTIQSDVWSFGVLLWEIFSLGA-SPYPGVKIDEEFCRRL----KEGTR----MR---APDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL--
---LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAVKML-KP-SAHLTEREALMSELKVLSYLGNHMNIVNLLGACT-IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI-------KNDSNY--------------VVKGNARLPVKWMAPESIFNCV---YTFESDVWSYGIFLWELFSLGS-SPYPGMPVDSKFYKMI----KEGFR----ML---SPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQL-I-
---VHFNEVIGRGHFGCVYHGTLL-------------DNDGKKIHCAVKSL-NR-ITDIGEVSQFLTEGIIMKDF-SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNE--------------------------------------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDM-------YDKEYYS------------VHNKTGAKLPVKWMALESLQTQK---FTTKSDVWSFGVLLWELMTRGA-PPYPDV-NTFDITVYL----LQGRR----LL---QPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSR-I-
--I-EYVRDIGEGAFGRVFQARAPG-----------LLPYEPFTMVAVKML-KE-EASADMQADFQREAALMAEF-DNPNIVKLLGVCA-VGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNI-------YSADYY--------------KANENDAIPIRWMPPESIFYNR---YTTESDVWAYGVVLWEIFSYGL-QPYYGM-AHEEVIYYV----RDGNI----LS---CPENCPVELYNLMRLCWSKLPADRPSFTSIHRIL--
--I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKILVAVKTL-KD-ASDNA-RKDFHREAELLTNL-QHEHIVKFYGVCV-EGDPLIMVFEYMKHGDLNKFLRAHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDV-------YSTDYY--------------RVGGHTMLPIRWMPPESIMYRK---FTTESDVWSLGVVLWEIFTYGK-QPWYQL-SNNEVIECI----TQGRV----LQ---RPRTCPQEVYELMLGCWQREPHMRKNIKGIHTL-L-
--I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKMLVAVKAL-KD-PTLAA-RKDFQREAELLTNL-QHEHIVKFYGVCG-DGDPLIMVFEYMKHGDLNKFLRAHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDV-------YSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRK---FTTESDVWSFGVILWEIFTYGK-QPWFQL-SNTEVIECI----TQGRV----LE---RPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL--
--L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAVKML-KP-TARSSEKQALMSELKIMTHLGPHLNIVNLLGACT-KSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI-------MHDSNY--------------VSKGSTFLPVKWMAPESIFDNL---YTTLSDVWSYGILLWEIFSLGG-TPYPGMMVDSTFYNKI----KSGYR----MA---KPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE--IV
--L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAVKML-KS-TARSSEKQALMSELKIMSHLGPHLNVVNLLGACT-KGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI-------MRDSNY--------------ISKGSTFLPLKWMAPESIFNSL---YTTLSDVWSFGILLWEIFTLGG-TPYPELPMNEQFYNAI----KRGYR----MA---QPAHASDEIYEIMQKCWEEKFEIRPPFSQLVL--LL
LES----AELDSGGFGKVSLCFHR-----------------TQGLMIMKTVYKG-PNCIEHNEALLEEAKMMNRL-RHSRVVKLLGVII-EEGKYSLVMEYMEKGNLMHVLKAE---------------------------------------------------------------------------------------------------MSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNE--EHNELR--------EVDGTAKKNGGTLYYMAPEHLNDVNA-KPTEKSDVYSFAVVLWAIFA-NK-EPYENAICEQQLIMCI----KSGNR----PDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEK-F-
---IKFQDVIGEGNFGQVLKARIK--------------KDGLRMDAAIKRM-KE-YASKDDHRDFAGELEVLCKLGHHPNIINLLGACE-HRGYLYLAIEYAPHGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ----------EVY--------------VKKTMGRLPVRWMAIESLNYSV---YTTNSDVWSYGVLLWEIVSLGG-TPYCGM-TCAELYEKL----PQGYR----LE---KPLNCDDEVYDLMRQCWREKPYERPSFAQILV--SL
---ITFEDLIGEGNFGQVIRAMIK--------------KDGLKMNAAIKML-KE-YASENDHRDFAGELEVLCKLGHHPNIINLLGACK-NRGYLYIAIEYAPYGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGE----------EVY--------------VKKTMGRLPVRWMAIESLNYSV---YTTKSDVWSFGVLLWEIVSLGG-TPYCGM-TCAELYEKL----PQGYR----ME---QPRNCDDEVYELMRQCWRDRPYERPPFAQIALQ-L-
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