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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK DDR1 203
TK ABL1 261
TK ABL2 288
TKL BRAF 456
TK CSF1R 582
TK EPHA1 624
TK EPHA3 621
TK INSR 1023
TK KDR 834
TK KIT 589
TK LCK 245
CMGC MAPK14 24
TK NTRK2 538
TK NTRK3 538
TK PDGFRA 593
TK PDGFRB 600
TK TEK 824
TK TIE1 839
--LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR-P-DAT-KNARNDFL-KEVKIMSRL-KDPNIIRLLGVCV-Q------DDPLCMITDYMENGDLNQFLSAHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYA--GDYY--------------RVQGRAVLPIRWMAWECIL-MGK---FTTASDVWAFGVTLWEVLMLCRAQPFGQL-TDEQVIENAGEFFRDQGRQ-VYLSRPPACP------------------------------QGLYELMLRCWSRESEQRPPFSQLHRFL---
--ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTLK-E-DTM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCT-R------EPPFYIITEFMTYGNLLDYLREC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-T--GDTY--------------TAHAGAKFPIKWTAPESLA-YNK---FSIKSDVWAFGVLLWEIATYGM-SPYPGI-DLSQVYELL----EKDYR----MERPEGCP------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F-
--ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTLK-E-DTM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCT-L------EPPFYIVTEYMPYGNLLDYLREC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM-T--GDTY--------------TAHAGAKFPIKWTAPESLA-YNT---FSIKSDVWAFGVLLWEIATYGM-SPYPGI-DLSQVYDLL----EKGYR----MEQPEGCP------------------------------PKVYELMRACWKWSPADRPSFAETHQA--F-
--ITVGQRIGSGSFGTVYKGKWH-------------------GDVAVKMLN-VTAPT-PQQLQAFK-NEVGVLRKT-RHVNILLFMGYST--------KPQLAIVTQWCEGSSLYHHLHII--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--WSGS--------------HQFEQLSGSILWMAPEVIR-MQDKNPYSFQSDVYAFGIVLYELMT-GQ-LPYSNINNRDQIIFMV----GRGYLSPDLSKVRSNCP------------------------------KAMKRLMAECLKKKRDERPLFPQILA---SI
--LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAVKMLK-S-TAH-ADEKEALM-SELKIMSHLGQHENIVNLLGACT-H------GGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMN--DSNY--------------IVKGNARLPVKWMAPESIF-DCV---YTVQSDVWSYGILLWEIFSLGL-NPYPGILVNSKFYKLV----KDGYQ----MAQPAFAP------------------------------KNIYSIMQACWALEPTHRPTFQQICSFL---
LM--VDTVIGEGEFGEVYRGTLR-------------LPSQDCKTVAIKTLK-D-TSP-GGQWWNFL-REATIMGQF-SHPHILHLEGVVT-K------RKPIMIITEFMENGALDAFLRER--------------------------------------------------------------------------------------------------EDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDD--FDGT--------------YETQGGKIPIRWTAPEAIA-HRI---FTTASDVWSFGIVMWEVLSFGD-KPYGEM-SNQEVMKSI----EDGYR----LPPPVDCP------------------------------APLYELMKNCWAYDRARRPHFQKLQAHL---
-I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEISVAIKTLK-V-GYT-EKQRRDFL-GEASIMGQF-DHPNIIRLEGVVT-K------SKPVMIVTEYMENGSLDSFLRKH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLED--DPEA-------------AYTTRGGKIPIRWTSPEAIA-YRK---FTSASDVWSYGIVLWEVMSYGE-RPYWEM-SNQDVIKAV----DEGYR----LPPPMDCP------------------------------AALYQLMLDCWQKDRNNRPKFEQIVSIL---
--ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAVKTVN-E-SAS-LRERIEFL-NEASVMKGF-TCHHVVRLLGVVS-K------GQPTLVVMELMAHGDLKSYLRSLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYE--TDYY--------------RKGGKGLLPVRWMAPESLK-DGV---FTTSSDMWSFGVVLWEITSLAE-QPYQGL-SNEQVLKFV----MDGGY----LDQPDNCP------------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL---
--LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAVKMLK-E-GAT-HSEHRALM-SELKILIHIGHHLNVVNLLGACTKP------GGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYK--DPDY--------------VRKGDARLPLKWMAPETIF-DRV---YTIQSDVWSFGVLLWEIFSLGA-SPYPGVKIDEEFCRRL----KEGTR----MRAPDYTT------------------------------PEMYQTMLDCWHGEPSQRPTFSELVEHL---
--LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAVKMLK-P-SAH-LTEREALM-SELKVLSYLGNHMNIVNLLGACT-I------GGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKN--DSNY--------------VVKGNARLPVKWMAPESIF-NCV---YTFESDVWSYGIFLWELFSLGS-SPYPGMPVDSKFYKMI----KEGFR----MLSPEHAP------------------------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I-
--LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSLK-Q-GSM-SP--DAFL-AEANLMKQL-QHQRLVRLYAVVT--------QEPIYIITEYMENGSLVDFLKTP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI-E--DNEY--------------TAREGAKFPIKWTAPEAIN-YGT---FTIKSDVWSFGILLTEIVTHGR-IPYPGM-TNPEVIQNL----ERGYR----MVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-
--YQNLSPVGSGAYGSVCAAFDT----------------KTGLRVAVKKLSRP-FQSIIH--AKRTYRELRLLKHM-KHENVIGLLDVFT-PARSLEEFNDVYLVTHLMGA-DLNNIVKCQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR----HTDDEM--------------TG---YVATRWYRAPEIMLNWMH---YNQTVDIWSVGCIMAELLT-GR-TLFPGT-DHIDQLKLI----LRLVG----TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-
-I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKILVAVKTLK-D-ASD-NA-RKDFH-REAELLTNL-QHEHIVKFYGVCV-E------GDPLIMVFEYMKHGDLNKFLRAHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYS--TDYY--------------RVGGHTMLPIRWMPPESIM-YRK---FTTESDVWSLGVVLWEIFTYGK-QPWYQL-SNNEVIECI----TQGRV----LQRPRTCP------------------------------QEVYELMLGCWQREPHMRKNIKGIHTL--L-
-I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKMLVAVKALK-D-PTL-AA-RKDFQ-REAELLTNL-QHEHIVKFYGVCG-D------GDPLIMVFEYMKHGDLNKFLRAHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYS--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-YRK---FTTESDVWSFGVILWEIFTYGK-QPWFQL-SNTEVIECI----TQGRV----LERPRVCP------------------------------KEVYDVMLGCWQREPQQRLNIKEIYKIL---
-L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAVKMLK-P-TAR-SSEKQALM-SELKIMTHLGPHLNIVNLLGACT-K------SGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMH--DSNY--------------VSKGSTFLPVKWMAPESIF-DNL---YTTLSDVWSYGILLWEIFSLGG-TPYPGMMVDSTFYNKI----KSGYR----MAKPDHAT------------------------------SEVYEIMVKCWNSEPEKRPSFYHLSE---IV
-L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAVKMLK-S-TAR-SSEKQALM-SELKIMSHLGPHLNVVNLLGACT-K------GGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMR--DSNY--------------ISKGSTFLPLKWMAPESIF-NSL---YTTLSDVWSFGILLWEIFTLGG-TPYPELPMNEQFYNAI----KRGYR----MAQPAHAS------------------------------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL
--IKFQDVIGEGNFGQVLKARIK--------------KDGLRMDAAIKRMK-E-YAS-KDDHRDFA-GELEVLCKLGHHPNIINLLGACE-H------RGYLYLAIEYAPHGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ-----EVY--------------VKKTMGRLPVRWMAIESLN-YSV---YTTNSDVWSYGVLLWEIVSLGG-TPYCGM-TCAELYEKL----PQGYR----LEKPLNCD------------------------------DEVYDLMRQCWREKPYERPSFAQILV---SL
--ITFEDLIGEGNFGQVIRAMIK--------------KDGLKMNAAIKMLK-E-YAS-ENDHRDFA-GELEVLCKLGHHPNIINLLGACK-N------RGYLYIAIEYAPYGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGE-----EVY--------------VKKTMGRLPVRWMAIESLN-YSV---YTTKSDVWSFGVLLWEIVSLGG-TPYCGM-TCAELYEKL----PQGYR----MEQPRNCD------------------------------DEVYELMRQCWRDRPYERPPFAQIALQ--L-
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