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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK DDR1 203
TK ABL1 261
TK ABL2 288
TKL ACVR1 208
TKL ACVRL1 202
TK ALK 1116
TK BLK 241
TKL BMPR1B 204
TK BMX 422
TK BTK 402
CAMK CHEK1 9
TK CSF1R 582
TK CSK 195
TK DDR2 563
TK EGFR 712
TK EPHA1 624
TK EPHA3 621
TK EPHA4 621
TK EPHA5 675
TK EPHA6 631
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB3 633
TK EPHB4 615
TK EPHB6 670
TK ERBB2 720
TK ERBB3 709
TK ERBB4 718
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FRK 234
TK FYN 271
TK HCK 241
CAMK HUNK 61
TK IGF1R 999
TK INSR 1023
TK INSRR 979
TKL IRAK1 212
TKL IRAK4 186
TK ITK 363
TK JAK2 849
TK JAK3 822
CAMK KIAA0999 66
TK KIT 589
TK LCK 245
TK LTK 510
TK LYN 247
STE MAP2K5 166
CMGC MAPK14 24
TK MATK 235
CAMK MGC42105 74
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
CAMK NUAK2 97
TK PDGFRA 593
TK PDGFRB 600
AGC PKN2 657
Other PLK2 82
AGC PRKCA 339
AGC PRKCD 349
AGC PRKCQ 380
TK PTK2B 425
TK PTK6 191
TK RET 724
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA6 73
CAMK SIK1 27
CAMK SIK2 20
TK SRC 270
TK SRMS 230
STE STK24 24
Other STK36 4
STE STK39 63
TK SYK 371
TK TEC 370
TK TNK2 150
TK TXK 271
TK TYK2 589
Other ULK3 14
TK YES1 277
TK ZAP70 338
-------LRFKEKLGEGQFGEV---HLCEVDSPQDLVSLDFPLNVRKGHPL---LVAVKILR-P--DAT-KNA-RN-DFL-K--EVKIMSRL--K---DPNIIRLLGVCV--Q------DDPLCMITDYMENGDLNQFLS---------AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATL--------NFVHRDLATRNCLVG--E---NFTIKIADFGMSRNL------Y-----A--GDYY--------------RVQGRAVLPIRWMAWECIL------MGKFTTASDVWAFGVTLWEVLMLCRA-------------QP---------------FGQL-----TDEQVIENAGEFFRD----QGRQVYLSRPPACP-------------------------------------------QGLYE-LMLRCWSRESEQRPP-----FS-QLHRFL----------------
-------ITMKHKLGGGQYGEV---YEGVWK----------------KYSL---TVAVKTLK-E--DTM-EV---E-EFL-K--EAAVMKEI--K---HPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR---------EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVG--E---NHLVKVADFGLSRLM------------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNKFSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYELL----EK----DYR---MERPEGCP-------------------------------------------EKVYE-LMRACWQWNPSDRPS-----FA-EIHQA--F--------------
-------ITMKHKLGGGQYGEV---YVGVWK----------------KYSL---TVAVKTLK-E--DTM-EV---E-EFL-K--EAAVMKEI--K---HPNLVQLLGVCT--L------EPPFYIVTEYMPYGNLLDYLR---------EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVG--E---NHVVKVADFGLSRLM------------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNTFSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYDLL----EK----GYR---MEQPEGCP-------------------------------------------PKVYE-LMRACWKWSPADRPS-----FA-ETHQA--F--------------
------I-TLLECVGKGRYGEV---WRGSWQ----------------GEN-----VAVKIFSSR--DEKSWF---R-ET-----ELYNTVML--R---HENILGFIASDM--TSR--HSSTQLWLITHYHEMGSLYDYLQ---------LT----------------------------------------------------------------------------------------------------TLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVK--K---NGQCCIADLGLAVMHSQ--------STNQLDVGN--------------NP---RVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVAR-RMVSNGI----VEDYKPP---------------FYDVVPNDPSFEDMRKVV----CV----DQQ---RPNIPNRWFSDPTL-------------------------------------TSLAK-LMKECWYQNPSARLT-----AL-RIKK----TL------------
-----VA--LVECVGKGRYGEV---WRGLWH----------------GES-----VAVKIFSSR--DEQSWF---R-ET-----EIYNTVLL--R---HDNILGFIASDM--TSR--NSSTQLWLITHYHEHGSLYDFLQ---------RQ----------------------------------------------------------------------------------------------------TLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVK--S---NLQCCIADLGLAVMHSQ--------GSDYLDIGN--------------NP---RVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIAR-RTIVNGI----VEDYRPP---------------FYDVVPNDPSFEDMKKVV----CV----DQQ---TPTIPNRLAADPVL-------------------------------------SGLAQ-MMRECWYPNPSARLT-----AL-RIKK----TLQ-----------
------I-TLIRGLGHGAFGEV---YEGQVSG-----------MPNDPSPL---QVAVKTLP-E--VCS-EQD-EL-DFL-M--EALIISKF--N---HQNIVRCIGVSL--Q------SLPRFILLELMAGGDLKSFLR---------ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN--------HFIHRDIAARNCLLT--CPGPGRVAKIGDFGMARDI------Y-----R--ASYY--------------RKGGCAMLPVKWMPPEAFM------EGIFTSKTDTWSFGVLLWEIFSLGY--------------MP---------------YPSK-----SNQEVLEFV----TS----GGR---MDPPKNCP-------------------------------------------GPVYR-IMTQCWQHQPEDRPN-----FA-IILER--I--------------
------L-RLVRKLGSGQFGEV---WMGYYK-----------------NNM---KVAIKTLK-E--GTM-SP---E-AFL-G--EANVMKAL--Q---HERLVRLYAVVT---------KEPIYIVTEYMARGCLLDFLK---------TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERM--------NSIHRDLRAANILVS--E---ALCCKIADFGLARII---------------DSEY--------------TAQEGAKFPIKWTAPEAIH------FGVFTIKADVWSFGVLLMEVVTYGR--------------VP---------------YPGM-----SNPEVIRNL----ER----GYR---MPRPDTCP-------------------------------------------PELYRGVIAECWRSRPEERPT-----FE-FLQSV--L--------------
------I-QMVKQIGKGRYGEV---WMGKWR----------------GEK-----VAVKVFFTT--EEASWF---R-ET-----EIYQTVLM--R---HENILGFIAADI--KGT--GSWTQLYLITDYHENGSLYDYLK---------ST----------------------------------------------------------------------------------------------------TLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVK--K---NGTCCIADLGLAVKFIS--------DTNEVDIPP--------------NT---RVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVAR-RCVSGGIVEEYQLPYHD-------------------LVPSDPSYEDMREIV----CI----KKL---RPSFPNRWSSDECL-------------------------------------RQMGK-LMTECWAHNPASRLT-----AL-RVKK----TL------------
-------ITLLKELGSGQFGVV---QLGKWK-----------------GQY---DVAVKMIK-E--GSM-SE---D-EFF-Q--EAQTMMKL--S---HPKLVKFYGVCS--K------EYPIYIVTEYISNGCLLNYLR---------SH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESH--------QFIHRDLAARNCLVD--R---DLCVKVSDFGMTRYV------------L--DDQY--------------VSSVGTKFPVKWSAPEVFH------YFKYSSKSDVWAFGILMWEVFSLGK--------------QP---------------YDLY-----DNSQVVLKV----SQ----GHR---LYRPHLAS-------------------------------------------DTIYQ-IMYSCWHELPEKRPT-----FQ-QLLSS--I--------------
-------LTFLKELGTGQFGVV---KYGKWR-----------------GQY---DVAIKMIK-E--GSM-SE---D-EFI-E--EAKVMMNL--S---HEKLVQLYGVCT--K------QRPIFIITEYMANGCLLNYLR---------EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESK--------QFLHRDLAARNCLVN--D---QGVVKVSDFGLSRYV------------L--DDEY--------------TSSVGSKFPVRWSPPEVLM------YSKFSSKSDIWAFGVLMWEIYSLGK--------------MP---------------YERF-----TNSETAEHI----AQ----GLR---LYRPHLAS-------------------------------------------EKVYT-IMYSCWHEKADERPT-----FK-ILLSN--I--------------
------W-DLVQTLGEGAYGEV---QLAVNR----------------VTEE---AVAVKIVDMK--RAVDCP---E-NI-KK--EICINKML--N---HENVVKFYGHRR--E------GNIQYLFLEYCSGGELFDRIE--------PDI----------------------------------------------------------------------------------------------------GMPEPDAQRFFHQLMAGVVYLHGI--------GITHRDIKPENLLLD--E---RDNLKISDFGLATVFR----------YNNRERLL--------------NK---MCGTLPYVAPELLK-----RREFHAEPVDVWSCGIVLTAMLA-GE--------------LP---------------WDQP-------SDSCQEY----SD----WKE---KKTYLNPWKKI--D-------------------------------------SAPLA-LLHKILVENPSARIT-----IP-DIKKDRW-Y-------------
-------LQFGKTLGAGAFGKV---VEATAFG-----------LGKEDAVL---KVAVKMLK-S--TAH-ADE-KE-ALM-S--ELKIMSHLG-Q---HENIVNLLGACT--H------GGPVLVITEYCCYGDLLNFLR---------RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASK--------NCIHRDVAARNVLLT--N---GHVAKIGDFGLARDI------M-----N--DSNY--------------IVKGNARLPVKWMAPESIF------DCVYTVQSDVWSYGILLWEIFSLGL--------------NP---------------YPGI-L---VNSKFYKLV----KD----GYQ---MAQPAFAP-------------------------------------------KNIYS-IMQACWALEPTHRPT-----FQ-QICSFL----------------
-------LKLLQTIGKGEFGDV---MLGDYR------------------GN---KVAVKCIK-N--DAT-AQ-----AFL-A--EASVMTQL--R---HSNLVQLLGVIV-EE------KGGLYIVTEYMAKGSLVDYLR---------SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGN--------NFVHRDLAARNVLVS--E---DNVAKVSDFGLTKEA------------------S--------------STQDTGKLPVKWTAPEALR------EKKFSTKSDVWSFGILLWEIYSFGR--------------VP---------------YPRI-----PLKDVVPRV----EK----GYK---MDAPDGCP-------------------------------------------PAVYE-VMKNCWHLDAAMRPS-----FL-QLREQL----------------
-------LTFKEKLGEGQFGEV---HLCEVEGMEKFKDKDFALDVSANQPV---LVAVKMLR-A--DAN-KNA-RN-DFL-K--EIKIMSRL--K---DPNIIHLLAVCI--T------DDPLCMITEYMENGDLNQFLS---------RHEPPN-----------------------------------------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSSL--------NFVHRDLATRNCLVG--K---NYTIKIADFGMSRNL------Y-----S--GDYY--------------RIQGRAVLPIRWMSWESIL------LGKFTTASDVWAFGVTLWETFTFCQE-------------QP---------------YSQL-----SDEQVIENT----GEFFRDQGRQTYLPQPAICP-------------------------------------------DSVYK-LMLSCWRRDTKNRPS-----FQ-EIHL---LL-------------
------F-KKIKVLGSGAFGTV---YKGLWIP------------EGEKVKI---PVAIKELR-E--ATS-PKA-NK-EIL-D--EAYVMASV--D---NPHVCRLLGICL---------TSTVQLITQLMPFGCLLDYVR---------EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR--------RLVHRDLAARNVLVK--T---PQHVKITDFGLAKLL------G-----A--EEKE--------------YHAEGGKVPIKWMALESIL------HRIYTHQSDVWSYGVTVWELMTFGS--------------KP---------------YDGI-----PASEISSIL----EK----GER---LPQPPICT-------------------------------------------IDVYM-IMVKCWMIDADSRPK-----FR-ELI----IEF------------
-----LM--VDTVIGEGEFGEV---YRGTLR-------------LPSQDCK---TVAIKTLK-D--TSP-GGQ-WW-NFL-R--EATIMGQF--S---HPHILHLEGVVT--K------RKPIMIITEFMENGALDAFLR---------ER--------------------------------------------------------------------------------------------------EDQLVPGQLVAMLQGIASGMNYLSNH--------NYVHRDLAARNILVN--Q---NLCCKVSDFGLTRLL------D-----D--FDGT--------------YETQGGKIPIRWTAPEAIA------HRIFTTASDVWSFGIVMWEVLSFGD--------------KP---------------YGEM-----SNQEVMKSI----ED----GYR---LPPPVDCP-------------------------------------------APLYE-LMKNCWAYDRARRPH-----FQ-KLQAHL----------------
------I-SIDKVVGAGEFGEV---CSGRLK-------------LPSKKEI---SVAIKTLK-V--GYT-EKQ-RR-DFL-G--EASIMGQF--D---HPNIIRLEGVVT--K------SKPVMIVTEYMENGSLDSFLR---------KH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDM--------GYVHRDLAARNILIN--S---NLVCKVSDFGLSRVL------E-----D--DPEA-------------AYTTRGGKIPIRWTSPEAIA------YRKFTSASDVWSYGIVLWEVMSYGE--------------RP---------------YWEM-----SNQDVIKAV----DE----GYR---LPPPMDCP-------------------------------------------AALYQ-LMLDCWQKDRNNRPK-----FE-QIVSIL----------------
-------IKIEKVIGVGEFGEV---CSGRLK-------------VPGKREI---CVAIKTLK-A--GYT-DKQ-RR-DFL-S--EASIMGQF--D---HPNIIHLEGVVT--K------CKPVMIITEYMENGSLDAFLR---------KN--------------------------------------------------------------------------------------------------DGRFTVIQLVGMLRGIGSGMKYLSDM--------SYVHRDLAARNILVN--S---NLVCKVSDFGMSRVL------E-----D--DPEA-------------AYTTRGGKIPIRWTAPEAIA------YRKFTSASDVWSYGIVMWEVMSYGE--------------RP---------------YWDM-----SNQDVIKAI----EE----GYR---LPPPMDCP-------------------------------------------IALHQ-LMLDCWQKERSDRPK-----FG-QIVNML----------------
-------ITIERVIGAGEFGEV---CSGRLK-------------LPGKREL---PVAIKTLK-V--GYT-EKQ-RR-DFL-G--EASIMGQF--D---HPNIIHLEGVVT--K------SKPVMIVTEYMENGSLDTFLK---------KN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGISAGMKYLSDM--------GYVHRDLAARNILIN--S---NLVCKVSDFGLSRVL------E-----D--DPEA-------------AYTTRGGKIPIRWTAPEAIA------FRKFTSASDVWSYGIVMWEVVSYGE--------------RP---------------YWEM-----TNQDVIKAV----EE----GYR---LPSPMDCP-------------------------------------------AALYQ-LMLDCWQKERNSRPK-----FD-EIVNML----------------
LPPRIPA----------------------------------------------------------------------------------------------------------------GRPVMIVVEYMENGSLDSFLR---------KH--------------------------------------------------------------------------------------------------DGHFTVIQLVGMLRGIASGMKYLSDM--------GYVHRDLAARNILVN--S---NLVCKVSDFGLSRVL------E-----D--DPEA-------------AYTTTGGKIPIRWTAPEAIA------YRKFSSASDAWSYGIVMWEVMSYGE--------------RP---------------YWEM-----SNQDVILSI----EE----GYR---LPAPMGCP-------------------------------------------ASLHQ-LMLHCWQKERNHRPK-----FT-DIVSFL----------------
-------IHIEKIIGSGDSGEV---CYGRLR-------------VPGQRDV---PVAIKALK-A--GYT-ERQ-RR-DFL-S--EASIMGQF--D---HPNIIRLEGVVT--R------GRLAMIVTEYMENGSLDTFLR---------TH--------------------------------------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSDL--------GYVHRDLAARNVLVD--S---NLVCKVSDFGLSRVL------E-----D--DPDA-------------AYTTTGGKIPIRWTAPEAIA------FRTFSSASDVWSFGVVMWEVLAYGE--------------RP---------------YWNM-----TNRDVISSV----EE----GYR---LPAPMGCP-------------------------------------------HALHQ-LMLDCWHKDRAQRPR-----FS-QIVSVL----------------
------V-KIEEVIGAGEFGEV---YKGRLK-------------LPGKREI---YVAIKTLK-A--GYS-EKQ-RR-DFL-S--EASIMGQF--D---HPNIIRLEGVVT--K------SRPVMIITEFMENGALDSFLR---------QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEM--------NYVHRDLAARNILVN--S---NLVCKVSDFGLSRYLQ---DDT-----S--DPTY--------------TSSLGGKIPVRWTAPEAIA------YRKFTSASDVWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDVINAI----EQ----DYR---LPPPMDCP-------------------------------------------AALHQ-LMLDCWQKDRNSRPR-----FA-EIVNTL----------------
------V-KIEQVIGAGEFGEV---CSGHLK-------------LPGKREI---FVAIKTLK-S--GYT-EKQ-RR-DFL-S--EASIMGQF--D---HPNVIHLEGVVT--K------STPVMIITEFMENGSLDSFLR---------QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADM--------NYVHRDLAARNILVN--S---NLVCKVSDFGLSRFLE---DDT-----S--DPTY--------------TSALGGKIPIRWTAPEAIQ------YRKFTSASDVWSYGIVMWEVMSYGE--------------RP---------------YWDM-----TNQDVINAI----EQ----DYR---LPPPMDCP-------------------------------------------SALHQ-LMLDCWQKDRNHRPK-----FG-QIVNTL----------------
------V-KIEEVIGAGEFGEV---CRGRLK-------------QPGRREV---FVAIKTLK-V--GYT-ERQ-RR-DFL-S--EASIMGQF--D---HPNIIRLEGVVT--K------SRPVMILTEFMENCALDSFLR---------LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLSEM--------NYVHRDLAARNILVN--S---NLVCKVSDFGLSRFLE---DDP-----S--DPTY--------------TSSLGGKIPIRWTAPEAIA------YRKFTSASDVWSYGIVMWEVMSYGE--------------RP---------------YWDM-----SNQDVINAV----EQ----DYR---LPPPMDCP-------------------------------------------TALHQ-LMLDCWVRDRNLRPK-----FS-QIVNTL----------------
------V-KIEEVIGAGEFGEV---CRGRLK-------------APGKKES---CVAIKTLK-G--GYT-ERQ-RR-EFL-S--EASIMGQF--E---HPNIIRLEGVVT--N------SMPVMILTEFMENGALDSFLR---------LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEM--------SYVHRDLAARNILVN--S---NLVCKVSDFGLSRFLE---ENS-----S--DPTY--------------TSSLGGKIPIRWTAPEAIA------FRKFTSASDAWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDVINAI----EQ----DYR---LPPPPDCP-------------------------------------------TSLHQ-LMLDCWQKDRNARPR-----FP-QVVSAL----------------
-------IKIEEVIGTGSFGEV---RQGRLQ-------------PRGRREQ---TVAIQALW-A--GGA-ESL-QM-TFL-G--RAAVLGQF--Q---HPNILRLEGVVT--K------SRPLMVLTEFMELGPLDSFLR---------QR--------------------------------------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSF--------AFVHRSLSAHSVLVN--S---HLVCKVARLGHSPQG--------------------------------------PSCLLRWAAPEVIA------HGKHTTSSDVWSFGILMWEVMSYGE--------------RP---------------YWDM-----SEQEVLNAI----EQ----EFR---LPPPPGCP-------------------------------------------PGLHL-LMLDTWQKDRARRPH-----FD-QLVA---AF-------------
------L-RKVKVLGSGAFGTV---YKGIWIP------------DGENVKI---PVAIKVLR-E--NTS-PKA-NK-EIL-D--EAYVMAGV--G---SPYVSRLLGICL---------TSTVQLVTQLMPYGCLLDHVR---------EN--------------------------------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLEDV--------RLVHRDLAARNVLVK--S---PNHVKITDFGLARLL------D-----I--DETE--------------YHADGGKVPIKWMALESIL------RRRFTHQSDVWSYGVTVWELMTFGA--------------KP---------------YDGI-----PAREIPDLL----EK----GER---LPQPPICT-------------------------------------------IDVYM-IMVKCWMIDSECRPR-----FR-ELVSE--F--------------
------L-RKLKVLGSGVFGTV---HKGVWIP------------EGESIKI---PVCIKVIE-D--KSG-RQS-FQ-AVT-D--HMLAIGSL--D---HAHIVRLLGLCP---------GSSLQLVTQYLPLGSLLDHVR---------QH--------------------------------------------------------------------------------------------------RGALGPQLLLNWGVQIAKGMYYLEEH--------GMVHRNLAARNVLLK--S---PSQVQVADFGVADLL------P-----P--DDKQ--------------LLYSEAKTPIKWMALESIH------FGKYTHQSDVWSYGVTVWELMTFGA--------------EP---------------YAGL-----RLAEVPDLL----EK----GER---LAQPQICT-------------------------------------------IDVYM-VMVKCWMIDENIRPT-----FK-ELANE--F--------------
------L-KRVKVLGSGAFGTV---YKGIWVP------------EGETVKI---PVAIKILN-E--TTG-PKA-NV-EFM-D--EALIMASM--D---HPHLVRLLGVCL---------SPTIQLVTQLMPHGCLLEYVH---------EH--------------------------------------------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEER--------RLVHRDLAARNVLVK--S---PNHVKITDFGLARLL------E-----G--DEKE--------------YNADGGKMPIKWMALECIH------YRKFTHQSDVWSYGVTIWELMTFGG--------------KP---------------YDGI-----PTREIPDLL----EK----GER---LPQPPICT-------------------------------------------IDVYM-VMVKCWMIDADSRPK-----FK-ELAAE--F--------------
-----VI--LGELLGKGNFGEV---YKGTLK-----------------DKT---SVAVKTCK-E--DLP-QEL-KI-KFL-Q--EAKILKQY--D---HPNIVKLIGVCT--Q------RQPVYIIMELVSGGDFLTFLR---------RK--------------------------------------------------------------------------------------------------KDELKLKQLVKFSLDAAAGMLYLESK--------NCIHRDLAARNCLVG--E---NNVLKISDFGMSRQE------------D--GGVY--------------SSSGLKQIPIKWTAPEALN------YGRYSSESDVWSFGILLWETFSLGV--------------CP---------------YPGM-----TNQQAREQV----ER----GYR---MSAPQHCP-------------------------------------------EDISK-IMMKCWDYKPENRPK-----FS-ELQKEL----------------
------L-VLGEQIGRGNFGEV---FSGRLR----------------ADNT---LVAVKSCR-E--TLP-PDL-KA-KFL-Q--EARILKQY--S---HPNIVRLIGVCT--Q------KQPIYIVMELVQGGDFLTFLR---------TE--------------------------------------------------------------------------------------------------GARLRVKTLLQMVGDAAAGMEYLESK--------CCIHRDLAARNCLVT--E---KNVLKISDFGMSREE------A-----D--GVYA--------------ASGGLRQVPVKWTAPEALN------YGRYSSESDVWSFGILLWETFSLGA--------------SP---------------YPNL-----SNQQTREFV----EK----GGR---LPCPELCP-------------------------------------------DAVFR-LMEQCWAYEPGQRPS-----FS-TIYQEL----------------
------L-VLGKPLGEGCFGQV---VLAEAIGL---------DKDKPNRVT---KVAVKMLK-S--DAT-EKD-LS-DLI-S--EMEMMKMIG-K---HKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLQ---------ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--------KCIHRDLAARNVLVT--E---DNVMKIADFGLARDI------H-----H--IDYY--------------KKTTNGRLPVKWMAPEALF------DRIYTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGV-----PVEELFKLL----KE----GHR---MDKPSNCT-------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FK-QLVEDL----------------
-------LTLGKPLGEGCFGQV---VMAEAVGI---------DKDKPKEAV---TVAVKMLK-D--DAT-EKD-LS-DLV-S--EMEMMKMIG-K---HKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLR---------ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ--------KCIHRDLAARNVLVT--E---NNVMKIADFGLARDI------N-----N--IDYY--------------KKTTNGRLPVKWMAPEALF------DRVYTHQSDVWSFGVLMWEIFTLGG--------------SP---------------YPGI-----PVEELFKLL----KE----GHR---MDKPANCT-------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FK-QLVEDL----------------
-------LTLGKPLGEGCFGQV---VMAEAIGI---------DKDRAAKPV---TVAVKMLK-D--DAT-DKD-LS-DLV-S--EMEMMKMIG-K---HKNIINLLGACT--Q------GGPLYVLVEYAAKGNLREFLR---------ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQ--------KCIHRDLAARNVLVT--E---DNVMKIADFGLARDV------H-----N--LDYY--------------KKTTNGRLPVKWMAPEALF------DRVYTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGI-----PVEELFKLL----KE----GHR---MDKPANCT-------------------------------------------HDLYM-IMRECWHAAPSQRPT-----FK-QLVEDL----------------
------L-VLGKPLGEGCFGQV---VRAEAFGM---------DPARPDQAS---TVAVKMLK-D--NAS-DKD-LA-DLV-S--EMEVMKLIG-R---HKNIINLLGVCT--Q------EGPLYVIVECAAKGNLREFLR---------ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESR--------KCIHRDLAARNVLVT--E---DNVMKIADFGLARGV------H-----H--IDYY--------------KKTSNGRLPVKWMAPEALF------DRVYTHQSDVWSFGILLWEIFTLGG--------------SP---------------YPGI-----PVEELFSLL----RE----GHR---MDRPPHCP-------------------------------------------PELYG-LMRECWHAAPSQRPT-----FK-QLVEAL----------------
-------ITLERRLGTGCFGDV---WLGTWN-----------------GST---KVAVKTLK-P--GTM-SP---K-AFL-E--EAQVMKLL--R---HDKLVQLYAVVS---------EEPIYIVTEFMCHGSLLDFLK---------NP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERM--------NYIHRDLRAANILVG--E---RLACKIADFGLARLI------------K--DDEY--------------NPCQGSKFPIKWTAPEAAL------FGRFTIKSDVWSFGILLTELITKGR--------------IP---------------YPGM-----NKREVLEQV----EQ----GYH---MPCPPGCP-------------------------------------------ASLYE-AMEQTWRLDPEERPT-----FE-YLQSFL----------------
-------IQLLKRLGSGQFGEV---WEGLWN-----------------NTT---PVAVKTLK-P--GSM-DP---N-DFL-R--EAQIMKNL--R---HPKLIQLYAVCT--L------EDPIYIITELMRHGSLQEYLQ---------ND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESR--------NYIHRDLAARNVLVG--E---HNIYKVADFGLARVFK----VD-----N--EDIY--------------ESRHEIKLPVKWTAPEAIR------SNKFSIKSDVWSFGILLYEIITYGK--------------MP---------------YSGM-----TGAQVIQML----AQ----NYR---LPQPSNCP-------------------------------------------QQFYN-IMLECWNAEPKERPT-----FE-TLRWK--L--------------
-------LQLIKRLGNGQFGEV---WMGTWN-----------------GNT---KVAIKTLK-P--GTM-SP---E-SFL-E--EAQIMKKL--K---HDKLVQLYAVVS---------EEPIYIVTEYMNKGSLLDFLK---------DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERM--------NYIHRDLRSANILVG--N---GLICKIADFGLARLI------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELVTKGR--------------VP---------------YPGM-----NNREVLEQV----ER----GYR---MPCPQDCP-------------------------------------------ISLHE-LMIHCWKKDPEERPT-----FE-YLQSFL----------------
-------LKLEKKLGAGQFGEV---WMATYN-----------------KHT---KVAVKTMK-P--GSM-SV---E-AFL-A--EANVMKTL--Q---HDKLVKLHAVVT---------KEPIYIITEFMAKGSLLDFLK---------SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR--------NYIHRDLRAANILVS--A---SLVCKIADFGLARVI------------E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGSFTIKSDVWSFGILLMEIVTYGR--------------IP---------------YPGM-----SNPEVIRAL----ER----GYR---MPRPENCP-------------------------------------------EELYN-IMMRCWKNRPEERPT-----FE-YIQSV--L--------------
----IGS----RKLGEGSFAKV---REGLHV----------------LTGE---KVAIKVIDKK--RAKKDT---Y-VTKNLRREGQIQQMI--R---HPNITQLLDILE--T------ENSYYLVMELCPGGNLMHKIY--------EKK----------------------------------------------------------------------------------------------------RLEESEARRYIRQLISAVEHLHRA--------GVVHRDLKIENLLLD--E---DNNIKLIDFGLSNCAG----------ILGYSDPF--------------ST---QCGSPAYAAPELLA------RKKYGPKIDVWSIGVNMYAMLT-GT--------------LP---------------FTVE------PFSLRALY----QK----MVD----KEMNPLPTQ--LS-------------------------------------TGAIS-FLRSLLEPDPVKRPN-----IQ-QALANRWL--------------
-------ITMSRELGQGSFGMV---YEGVAKG-----------VVKDEPET---RVAIKTVN-E--AAS-MRE-RI-EFL-N--EASVMKEF--N---CHHVVRLLGVVS--Q------GQPTLVIMELMTRGDLKSYLR---------SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNAN--------KFVHRDLAARNCMVA--E---DFTVKIGDFGMTRDI------Y-----E--TDYY--------------RKGGKGLLPVRWMSPESLK------DGVFTTYSDVWSFGVVLWEIATLAE--------------QP---------------YQGL-----SNEQVLRFV----ME----GGL---LDKPDNCP-------------------------------------------DMLFE-LMRMCWQYNPKMRPS-----FL-EIISS--I--------------
-------ITLLRELGQGSFGMV---YEGNARD-----------IIKGEAET---RVAVKTVN-E--SAS-LRE-RI-EFL-N--EASVMKGF--T---CHHVVRLLGVVS--K------GQPTLVVMELMAHGDLKSYLR---------SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK--------KFVHRDLAARNCMVA--H---DFTVKIGDFGMTRDI------Y-----E--TDYY--------------RKGGKGLLPVRWMAPESLK------DGVFTTSSDMWSFGVVLWEITSLAE--------------QP---------------YQGL-----SNEQVLKFV----MD----GGY---LDQPDNCP-------------------------------------------ERVTD-LMRMCWQFNPKMRPT-----FL-EIVNLL----------------
------I-SIIRELGQGSFGMV---YEGLARG-----------LEAGEEST---PVALKTVN-E--LAS-PRE-CI-EFL-K--EASVMKAF--K---CHHVVRLLGVVS--Q------GQPTLVIMELMTRGDLKSHLR---------SLRPEA-----------------------------------------------------------------------------------------ENNPGLPQPALGEMIQMAGEIADGMAYLAAN--------KFVHRDLAARNCMVS--Q---DFTVKIGDFGMTRDV------Y-----E--TDYY--------------RKGGKGLLPVRWMAPESLK------DGIFTTHSDVWSFGVVLWEIVTLAE--------------QP---------------YQGL-----SNEQVLKFV----MD----GGV---LEELEGCP-------------------------------------------LQLQE-LMSRCWQPNPRLRPS-----FT-HILD---SI-------------
---FSEE----LKIGEGGFGCV---YRAVMR----------------NTV-----YAVKRLKEN--ADLEWT---A-VKQSFLTEVEQLSRF--R---HPNIVDFAGYCA--Q------NGFYCLVYGFLPNGSLEDRLHCQ----TQACP----------------------------------------------------------------------------------------------------PLSWPQRLDILLGTARAIQFLHQDS------PSLIHGDIKSSNVLLD--E---RLTPKLGDFGLARFSRFAG---SSPSQSSMVART--------------QT---VRGTLAYLPEEYIK------TGRLAVDTDTFSFGVVVLETLA-GQ--------------RA---------------VKTHG---AR-TKYLKDL----VE----EEA---EEAGVALRST---QSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQ-LACCCLHRRAKRRPP-----MT-QVYE----RL------------
----VGG----NKMGEGGFGVV---YKGYVN----------------NTT-----VAVKKLAAM--VDITTE---ELKQQFD-QEIKVMAKC--Q---HENLVELLGFSS--D------GDDLCLVYVYMPNGSLLDRLSC-----LDGTP----------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN--------HHIHRDIKSANILLD--E---AFTAKISDFGLARASE----------KFAQTVMT--------------SR---IVGTTAYMAPEALR-------GEITPKSDIYSFGVVLLEIIT-GL--------------PA---------------VDEH-----REPQLLLDI----KE----EIE---DEEKTIEDYIDKKMNDAD-----------------------------STSVEAMYS-VASQCLHEKKNKRPD-----IK-KVQQ----LLQ-----------
-------LTFVQEIGSGQFGLV---HLGYWL-----------------NKD---KVAIKTIR-E--GAM-SE---E-DFI-E--EAEVMMKL--S---HPKLVQLYGVCL--E------QAPICLVFEFMEHGCLSDYLR---------TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEA--------CVIHRDLAARNCLVG--E---NQVIKVSDFGMTRFV------------L--DDQY--------------TSSTGTKFPVKWASPEVFS------FSRYSSKSDVWSFGVLMWEVFSEGK--------------IP---------------YENR-----SNSEVVEDI----ST----GFR---LYKPRLAS-------------------------------------------THVYQ-IMNHCWKERPEDRPA-----FS-RLLRQL----------------
-------LKFLQQLGKGNFGSV---EMCRYDP------------LQDNTGE---VVAVKKLQ-H--STE--EH-LR-DFE-R--EIEILKSL--Q---HDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ---------KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK--------RYIHRDLATRNILVE--N---ENRVKIGDFGLTKVL-----PQ-----D--KEYY--------------KVKEPGESPIFWYAPESLT------ESKFSVASDVWSFGVVLYELFTYIE--------------KSKSPPAEFMRMIGNDKQGQM-----IVFHLIELL----KN----NGR---LPRPDGCP-------------------------------------------DEIYM-IMTECWNNNVNQRPS-----FR-DLA----LRV------------
------L-KYISQLGKGNFGSV---ELCRYDP------------LGDNTGA---LVAVKQLQ-H--SGP-DQ--QR-DFQ-R--EIQILKAL--H---SDFIVKYRGVSYGPG------RQSLRLVMEYLPSGCLRDFLQ---------RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSR--------RCVHRDLAARNILVE--S---EAHVKIADFGLAKLL-----PL-----D--KDYY--------------VVREPGQSPIFWYAPESLS------DNIFSRQSDVWSFGVVLYELFTYCD--------------KSCSPSAE--FLRMMGCERDV-P---ALCRLLELL----EE----GQR---LPAPPACP-------------------------------------------AEVHE-LMKLCWAPSPQDRPS-----FS-ALGP---QL-------------
-------YEIDRTIGKGNFAVV---KRATHL----------------VTKA---KVAIKIIDKT--QLDEEN---L-KKIFR--EVQIMKML--C---HPHIIRLYQVME--T------ERMIYLVTEYASGGEIFDHLV--------AHG----------------------------------------------------------------------------------------------------RMAEKEARRKFKQIVTAVYFCHCR--------NIVHRDLKAENLLLD--A---NLNIKIADFGFSNL-------------FTPGQLL--------------KT---WCGSPPYAAPELFE-----GKEYDGPKVDIWSLGVVLYVLVC-GA--------------LP---------------FDGS--------TLQNLR----AR----VLS---GKFRIPFFMS-----------------------------------------TECEH-LIRHMLVLDPNKRLS-----ME-QICKHKWM--------------
-------LSFGKTLGAGAFGKV---VEATAYG-----------LIKSDAAM---TVAVKMLK-P--SAH-LTE-RE-ALM-S--ELKVLSYLG-N---HMNIVNLLGACT--I------GGPTLVITEYCCYGDLLNFLR---------RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK--------NCIHRDLAARNILLT--H---GRITKICDFGLARDI------K-----N--DSNY--------------VVKGNARLPVKWMAPESIF------NCVYTFESDVWSYGIFLWELFSLGS--------------SP---------------YPGM-P---VDSKFYKMI----KE----GFR---MLSPEHAP-------------------------------------------AEMYD-IMKTCWDADPLKRPT-----FK-QIVQL--I--------------
-------LKLVERLGAGQFGEV---WMGYYN-----------------GHT---KVAVKSLK-Q--GSM-SP---D-AFL-A--EANLMKQL--Q---HQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK---------TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVS--D---TLSCKIADFGLARLI------------E--DNEY--------------TAREGAKFPIKWTAPEAIN------YGTFTIKSDVWSFGILLTEIVTHGR--------------IP---------------YPGM-----TNPEVIQNL----ER----GYR---MVRPDNCP-------------------------------------------EELYQ-LMRLCWKERPEDRPT-----FD-YLRSV--L--------------
------V-TLLRALGHGAFGEV---YEGLVIG-----------LPGDSSPL---QVAIKTLP-E--LCS-PQD-EL-DFL-M--EALIISKF--R---HQNIVRCVGLSL--R------ATPRLILLELMSGGDMKSFLR---------HSRP--------------------------------------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEEN--------HFIHRDIAARNCLLS--CAGPSRVAKIGDFGMARDI------Y-----R--ASYY--------------RRGDRALLPVKWMPPEAFL------EGIFTSKTDSWSFGVLLWEIFSLGY--------------MP---------------YPGR-----TNQEVLDFV----VG----GGR---MDPPRGCP-------------------------------------------GPVYR-IMTQCWQHEPELRPS-----FA-SILERL----------------
-------IKLVKRLGAGQFGEV---WMGYYN-----------------NST---KVAVKTLK-P--GTM-SV---Q-AFL-E--EANLMKTL--Q---HDKLVRLYAVVT--R------EEPIYIITEYMAKGSLLDFLK---------SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERK--------NYIHRDLRAANVLVS--E---SLMCKIADFGLARVI------------E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGCFTIKSDVWSFGILLYEIVTYGK--------------IP---------------YPGR-----TNADVMTAL----SQ----GYR---MPRVENCP-------------------------------------------DELYD-IMKMCWKEKAEERPT-----FD-YLQSV--L--------------
----IRY---RDTLGHGNGGTV---YKAYHV----------------PSGK---ILAVKVILLD--ITLELQ---K-QI-MS--ELEILYKC--D---SSYIIGFYGAFF--V------ENRISICTEFMDGGSLD------------VYR----------------------------------------------------------------------------------------------------KMPEHVLGRIAVAVVKGLTYLWSL--------KILHRDVKPSNMLVN--T---RGQVKLCDFGVST--------------QLVNSIA--------------KT---YVGTNAYMAPERIS------GEQYGIHSDVWSLGISFMELAL-GR--------------FP---------------YPQI-----QKNQGSLMP----LQ----LLQ---CIVDEDSPVLPVGEF-----------------------------------SEPFVH-FITQCMRKQPKERPA-----PE-ELMGHPFI--------------
-------YQNLSPVGSGAYGSV---CAAFDT----------------KTGL---RVAVKKLSRP--FQSIIH---A-KRTYR--ELRLLKHM--K---HENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK---------CQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSA--------DIIHRDLKPSNLAVN--E---DCELKILDFGLAR---------------HTDDEM--------------TG---YVATRWYRAPEIML-----NWMHYNQTVDIWSVGCIMAELLT-GR--------------TL---------------FPGT-----DHIDQLKLI----LR----LVG---TPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVD-LLEKMLVLDSDKRIT-----AA-QALAHAYF--------------
-------LTLGAQIGEGEFGAV---LQGEYL------------------GQ---KVAVKNIK-C--DVT-AQ-----AFL-D--ETAVMTKM--Q---HENLVRLLGVIL---------HQGLYIVMEHVSKGNLVNFLR---------TR-------------------------------------------------------------------------------------------------GRALVNTAQLLQFSLHVAEGMEYLESK--------KLVHRDLAARNILVS--E---DLVAKVSDFGLAKAE------------------R--------------KGLDSSRLPVKWTAPEALK------HGKFTSKSDVWSFGVLLWEVFSYGR--------------AP---------------YPKM-----SLKEVSEAV----EK----GYR---MEPPEGCP-------------------------------------------GPVHV-LMSSCWEAEPARRPP-----FR-KLAEKL----------------
-------YRIRGEIGSGNFSQV---KLGIHS----------------LTKE---KVAIKILDKT--KLDQKT---Q-RLLSR--EISSMEKL--H---HPNIIRLYEVVE--T------LSKLHLVMEYAGGGELFGKIS--------TEG----------------------------------------------------------------------------------------------------KLSEPESKLIFSQIVSAVKHMHEN--------QIIHRDLKAENVFYT--S---NTCVKVGDFGFSTV-------------SKKGEML--------------NT---FCGSPPYAAPELFR-----DEHYIGIYVDIWALGVLLYFMVT-GT--------------MP---------------FRAE--------TVAKLK----KS----ILE---GTYSVPPHV----S-------------------------------------EPCHR-LIRGVLQQIPTERYG-----ID-CIMNDEWM--------------
-----IV--LKWELGEGAFGKV---FLAECHN-----------LLPEQDKM---LVAVKALK-E--ASE-SA--RQ-DFQ-R--EAELLTML--Q---HQHIVRFFGVCT--E------GRPLLMVFEYMRHGDLNRFLR---------SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGL--------HFVHRDLATRNCLVG--Q---GLVVKIGDFGMSRDI------Y-----S--TDYY--------------RVGGRTMLPIRWMPPESIL------YRKFTTESDVWSFGVVLWEIFTYGK--------------QP---------------WYQL-----SNTEAIDCI----TQ----GRE---LERPRACP-------------------------------------------PEVYA-IMRGCWQREPQQRHS-----IK-DVHARL----------------
------I-VLKRELGEGAFGKV---FLAECYN-----------LCPEQDKI---LVAVKTLK-D--ASD-NA--RK-DFH-R--EAELLTNL--Q---HEHIVKFYGVCV--E------GDPLIMVFEYMKHGDLNKFLR---------AHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQ--------HFVHRDLATRNCLVG--E---NLLVKIGDFGMSRDV------Y-----S--TDYY--------------RVGGHTMLPIRWMPPESIM------YRKFTTESDVWSLGVVLWEIFTYGK--------------QP---------------WYQL-----SNNEVIECI----TQ----GRV---LQRPRTCP-------------------------------------------QEVYE-LMLGCWQREPHMRKN-----IK-GIHTL--L--------------
------I-VLKRELGEGAFGKV---FLAECYN-----------LSPTKDKM---LVAVKALK-D--PTL-AA--RK-DFQ-R--EAELLTNL--Q---HEHIVKFYGVCG--D------GDPLIMVFEYMKHGDLNKFLR---------AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQ--------HFVHRDLATRNCLVG--A---NLLVKIGDFGMSRDV------Y-----S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM------YRKFTTESDVWSFGVILWEIFTYGK--------------QP---------------WFQL-----SNTEVIECI----TQ----GRV---LERPRVCP-------------------------------------------KEVYD-VMLGCWQREPQQRLN-----IK-EIYKIL----------------
-------YELQETLGKGTYGKV---KRATER----------------FSGR---VVAIKSIRKD--KIKDEQ---D-MVHIR-REIEIMSSL--N---HPHIISIYEVFE--N------KDKIVIIMEYASKGELYDYIS--------ERR----------------------------------------------------------------------------------------------------RLSERETRHFFRQIVSAVHYCHKN--------GVVHRDLKLENILLD--D---NCNIKIADFGLSNL-------------YQKDKFL--------------QT---FCGSPLYASPEIVN-----GRPYRGPEVDSWALGVLLYTLVY-GT--------------MP---------------FDGF--------DHKNLI----RQ----ISS---GEYREPTQP------------------------------------------SDARG-LIRWMLMVNPDRRAT-----IE-DIANHWW-V-------------
-------YEFLETLGKGTYGKV---KKARES----------------SGR----LVAIKSIRKD--KIKDEQ---D-LMHIR-REIEIMSSL--N---HPHIIAIHEVFE--N------SSKIVIVMEYASRGDLYDYIS--------ERQ----------------------------------------------------------------------------------------------------QLSEREARHFFRQIVSAVHYCHQN--------RVVHRDLKLENILLD--A---NGNIKIADFGLSNL-------------YHQGKFL--------------QT---FCGSPLYASPEIVN-----GKPYTGPEVDSWSLGVLLYILVH-GT--------------MP---------------FDGH--------DHKILV----KQ----ISN---GAYREPPK-----P-------------------------------------SDACG-LIRWLLMVNPTRRAT-----LE-DVASHWW-V-------------
------L-VLGRVLGSGAFGKV---VEGTAYG-----------LSRSQPVM---KVAVKMLK-P--TAR-SSE-KQ-ALM-S--ELKIMTHLG-P---HLNIVNLLGACT--K------SGPIYIITEYCFYGDLVNYLH---------KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASK--------NCVHRDLAARNVLLA--Q---GKIVKICDFGLARDI------M-----H--DSNY--------------VSKGSTFLPVKWMAPESIF------DNLYTTLSDVWSYGILLWEIFSLGG--------------TP---------------YPGM-M---VDSTFYNKI----KS----GYR---MAKPDHAT-------------------------------------------SEVYE-IMVKCWNSEPEKRPS-----FY-HLSE---IV-------------
------L-VLGRTLGSGAFGQV---VEATAHG-----------LSHSQATM---KVAVKMLK-S--TAR-SSE-KQ-ALM-S--ELKIMSHLG-P---HLNVVNLLGACT--K------GGPIYIITEYCRYGDLVDYLH---------RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASK--------NCVHRDLAARNVLIC--E---GKLVKICDFGLARDI------M-----R--DSNY--------------ISKGSTFLPLKWMAPESIF------NSLYTTLSDVWSFGILLWEIFTLGG--------------TP---------------YPEL-P---MNEQFYNAI----KR----GYR---MAQPAHAS-------------------------------------------DEIYE-IMQKCWEEKFEIRPP-----FS-QLVL---LL-------------
-----FR--CCAVLGRGHFGKV---LLAEYK----------------NTNE---MFAIKALKKG--DIVARD---E-VDSLM-CEKRIFETV--NSVRHPFLVNLFACFQ--T------KEHVCFVMEYAAGGDLMMHIH---------TD----------------------------------------------------------------------------------------------------VFSEPRAVFYAACVVLGLQYLHEH--------KIVYRDLKLDNLLLD--T---EGFVKIADFGLCKEG------------MGYGDRT--------------ST---FCGTPEFLAPEVLT------ETSYTRAVDWWGLGVLIYEMLV-GE--------------SP---------------FPGD--------DEEEVF----DS----IVN---DEVRYPRFLS-----------------------------------------TEAIS-IMRRLLRRNPERRLGASEKDAE-DVKKHPFF--------------
------Y-CRGKVLGKGGFAKC---YEMTDL----------------TNNK---VYAAKIIPHS--RVAKPH---Q-REKID-KEIELHRIL--H---HKHVVQFYHYFE--D------KENIYILLEYCSRRSMAHILK--------ARK----------------------------------------------------------------------------------------------------VLTEPEVRYYLRQIVSGLKYLHEQ--------EILHRDLKLGNFFIN--E---AMELKVGDFGLAARL------------EPLEHRR--------------RT---ICGTPNYLSPEVLN------KQGHGCESDIWALGCVMYTMLL-GR--------------PP---------------FETT--------NLKETY----RC----IRE---ARYTMPSSLL-----------------------------------------APAKH-LIASMLSKNPEDRPS-----LD-DIIRHDFF--------------
------F-NFLMVLGKGSFGKV---MLADRK----------------GTEE---LYAIKILKKD--VVIQDD---D-VECTM-VEKRVLALL-DK---PPFLTQLHSCFQ--T------VDRLYFVMEYVNGGDLMYHIQ--------QVG----------------------------------------------------------------------------------------------------KFKEPQAVFYAAEISIGLFFLHKR--------GIIYRDLKLDNVMLD--S---EGHIKIADFGMCKEH------------MMDGVTT--------------RT---FCGTPDYIAPEIIA------YQPYGKSVDWWAYGVLLYEMLA-GQ--------------PP---------------FDGE--------DEDELF----QS----IME---HNVSYPKSLS-----------------------------------------KEAVS-VCKGLMTKHPAKRLG-----C----------GPEGERDVREHAFF
-----FI--FHKVLGKGSFGKV---LLGELK----------------GRGE---YFAIKALKKD--VVLIDD---D-VECTM-VEKRVLTLA-AE---NPFLTHLICTFQ--T------KDHLFFVMEFLNGGDLMYHIQ--------DKG----------------------------------------------------------------------------------------------------RFELYRATFYAAEIMCGLQFLHSK--------GIIYRDLKLDNVLLD--R---DGHIKIADFGMCKEN------------IFGESRA--------------ST---FCGTPDYIAPEILQ------GLKYTFSVDWWSFGVLLYEMLI-GQ--------------SP---------------FHGD--------DEDELF----ES----IRV---DTPHYPRWIT-----------------------------------------KESKD-ILEKLFEREPTKRLG----VTG-NIKIHPFF--------------
-----FI--LHKMLGKGSFGKV---FLAEFK----------------KTNQ---FFAIKALKKD--VVLMDD---D-VECTM-VEKRVLSLA-WE---HPFLTHMFCTFQ--T------KENLFFVMEYLNGGDLMYHIQ--------SCH----------------------------------------------------------------------------------------------------KFDLSRATFYAAEIILGLQFLHSK--------GIVYRDLKLDNILLD--K---DGHIKIADFGMCKEN------------MLGDAKT--------------NT---FCGTPDYIAPEILL------GQKYNHSVDWWSFGVLLYEMLI-GQ--------------SP---------------FHGQ--------DEEELF----HS----IRM---DNPFYPRWLE-----------------------------------------KEAKD-LLVKLFVREPEKRLG-----VRGDIRQHPLF--------------
------V-VLNRILGEGFFGEV---YEGVYT-------------NHKGEKI---NVAVKTCK-K--DCT-LDN-KE-KFM-S--EAVIMKNL--D---HPHIVKLIGIIE---------EEPTWIIMELYPYGELGHYLE---------RN--------------------------------------------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESI--------NCVHRDIAVRNILVA--S---PECVKLGDFGLSRYI------------E--DEDY--------------YKASVTRLPIKWMSPESIN------FRRFTTASDVWMFAVCMWEILSFGK--------------QP---------------FFWL-----ENKDVIGVL----EK----GDR---LPKPDLCP-------------------------------------------PVLYT-LMTRCWDYDPSDRPR-----FT-ELVCS--L--------------
------F-TLCRKLGSGYFGEV---FEGLWK-----------------DRV---QVAIKVIS-R--DNL-LH--QQ-MLQ-S--EIQAMKKL--R---HKHILALYAVVS--V------GDPVYIITELMAKGSLLELLR---------DS-------------------------------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQ--------NYIHRDLAARNILVG--E---NTLCKVGDFGLARLI---------------KEDV--------------YLSHDHNIPYKWTAPEALS------RGHYSTKSDVWSFGILLHEMFSRGQ--------------VP---------------YPGM-----SNHEAFLRV----DA----GYR---MPCPLECP-------------------------------------------PSVHK-LMLTCWCRDPEQRPC-----FK-ALRERL----------------
------L-VLGKTLGEGEFGKV---VKATAFH-----------LKGRAGYT---TVAVKMLK-E--NAS-PSE-LR-DLL-S--EFNVLKQV--N---HPHVIKLYGACS--Q------DGPLLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM--------KLVHRDLAARNILVA--E---GRKMKISDFGLSRDV------Y-----E--EDSY--------------VKRSQGRIPVKWMAIESLF------DHIYTTQSDVWSFGVLLWEIVTLGG--------------NP---------------YPGI-----PPERLFNLL----KT----GHR---MERPDNCS-------------------------------------------EEMYR-LMLQCWKQEPDKRPV-----FA-DISKDL----------------
-------FELLKVLGQGSFGKVFLVRKVTRP----------------DSGH---LYAMKVLKKA--TLKVRD---R-VRTKM--ERDILADV--N---HPFVVKLHYAFQ--T------EGKLYLILDFLRGGDLFTRLS--------KEV----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALGLDHLHSL--------GIIYRDLKPENILLD--E---EGHIKLTDFGLSKEA------------IDHEKKA--------------YS---FCGTVEYMAPEVVN------RQGHSHSADWWSYGVLMFEMLT-GS--------------LP---------------FQGK--------DRKETM----TL----ILK---AKLGMPQFLS-----------------------------------------TEAQS-LLRALFKRNPANRLGSGPDGAE-EIKRHV--FY------------
-------FELLKVLGQGSYGKV---FLVRKV----------------KGSDAGQLYAMKVLKKA--TLKVRD---R-VRSKM--ERDILAEV--N---HPFIVKLHYAFQ--T------EGKLYLILDFLRGGDLFTRLS--------KEV----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHSL--------GIIYRDLKPENILLD--E---EGHIKITDFGLSKEA------------IDHDKRA--------------YS---FCGTIEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GS--------------LP---------------FQGK--------DRKETM----AL----ILK---AKLGMPQFLS-----------------------------------------GEAQS-LLRALFKRNPCNRLGAGIDGVE-EIKRHPFF--------------
-------FELLKVLGQGSFGKV---FLVKKI----------------SGSDARQLYAMKVLKKA--TLKVRD---R-VRTKM--ERDILVEV--N---HPFIVKLHYAFQ--T------EGKLYLILDFLRGGDLFTRLS--------KEV----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHSL--------GIIYRDLKPENILLD--E---EGHIKLTDFGLSKES------------IDHEKKA--------------YS---FCGTVEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GT--------------LP---------------FQGK--------DRKETM----TM----ILK---AKLGMPQFLS-----------------------------------------PEAQS-LLRMLFKRNPANRLGAGPDGVE-EIKRHSFF--------------
-------FELLKVLGQGSFGKV---FLVRKK----------------TGPDAGQLYAMKVLKKA--SLKVRD---R-VRTKM--ERDILVEV--N---HPFIVKLHYAFQ--T------EGKLYLILDFLRGGDVFTRLS--------KEV----------------------------------------------------------------------------------------------------LFTEEDVKFYLAELALALDHLHQL--------GIVYRDLKPENILLD--E---IGHIKLTDFGLSKES------------VDQEKKA--------------YS---FCGTVEYMAPEVVN------RRGHSQSADWWSYGVLMFEMLT-GT--------------LP---------------FQGK--------DRNETM----NM----ILK---AKLGMPQFLS-----------------------------------------AEAQS-LLRMLFKRNPANRLGS--EGVE-EIKRHLFF--------------
-------YDIERTLGKGNFAVV---KLARHR----------------VTKT---QVAIKIIDKT--RLDSSN---L-EKIYR--EVQLMKLL--N---HPHIIKLYQVME--T------KDMLYIVTEFAKNGEMFDYLT--------SNG----------------------------------------------------------------------------------------------------HLSENEARKKFWQILSAVEYCHDH--------HIVHRDLKTENLLLD--G---NMDIKLADFGFGNF-------------YKSGEPL--------------ST---WCGSPPYAAPEVFE-----GKEYEGPQLDIWSLGVVLYVLVC-GS--------------LP---------------FDGP--------NLPTLR----QR----VLE---GRFRIPFFMS-----------------------------------------QDCES-LIRRMLVVDPARRIT-----IA-QIRQHRWM--------------
-------YDIEGTLGKGNFAVV---KLGRHR----------------ITKT---EVAIKIIDKS--QLDAVN---L-EKIYR--EVQIMKML--D---HPHIIKLYQVME--T------KSMLYLVTEYAKNGEIFDYLA--------NHG----------------------------------------------------------------------------------------------------RLNESEARRKFWQILSAVDYCHGR--------KIVHRDLKAENLLLD--N---NMNIKIADFGFGNF-------------FKSGELL--------------AT---WCGSPPYAAPEVFE-----GQQYEGPQLDIWSMGVVLYVLVC-GA--------------LP---------------FDGP--------TLPILR----QR----VLE---GRFRIPYFMS-----------------------------------------EDCEH-LIRRMLVLDPSKRLT-----IA-QIKEHKWM--------------
------L-RLEVKLGQGCFGEV---WMGTWN-----------------GTT---RVAIKTLK-P--GTM-SP---E-AFL-Q--EAQVMKKL--R---HEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK---------GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVG--E---NLVCKVADFGLARLI------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELTTKGR--------------VP---------------YPGM-----VNREVLDQV----ER----GYR---MPCPPECP-------------------------------------------ESLHD-LMCQCWRKEPEERPT-----FE-YLQAF--L--------------
-----FA--LGRKLGEGYFGEV---WEGLWL-----------------GSL---PVAIKVIK-S--ANM-K---LT-DLA-K--EIQTLKGL--R---HERLIRLHAVCS--G------GEPVYIVTELMRKGNLQAFLG---------TP-------------------------------------------------------------------------------------------------EGRALRLPPLLGFACQVAEGMSYLEEQ--------RVVHRDLAARNVLVD--D---GLACKVADFGLARLL------------K--DDIY--------------SPSSSSKIPVKWTAPEAAN------YRVFSQKSDVWSFGVLLHEVFTYGQ--------------CP---------------YEGM-----TNHETLQQI----MR----GYR---LPRPAACP-------------------------------------------AEVYV-LMLECWRSSPEERPS-----FA-TLREKL----------------
-------FTKLEKIGKGSFGEV---FKGIDN----------------RTQK---VVAIKIIDLE--EAEDEI---E-DIQ-Q--EITVLSQC--D---SPYVTKYYGSYL--K------DTKLWIIMEYLGGGSALDLLE---------PG----------------------------------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSE--------KKIHRDIKAANVLLS--E---HGEVKLADFGVAGQL------------TDTQIKR--------------NT---FVGTPFWMAPEVIK------QSAYDSKADIWSLGITAIELAR-GE--------------PP---------------HSEL-----HPMKVLFLI----PK----NNP---PTLEGNYS-------------------------------------------KPLKE-FVEACLNKEPSFRPT-----AK-ELLKHKFI--------------
-------YHVLEMIGEGSFGRV---YKGRRK----------------YSAQ---VVALKFIPKL--GRSEKE---L-RNLQR--EIEIMRGL--R---HPNIVHMLDSFE--T------DKEVVVVTDYAEG-ELFQILE--------DDG----------------------------------------------------------------------------------------------------KLPEDQVQAIAAQLVSALYYLHSH--------RILHRDMKPQNILLA--K---GGGIKLCDFGFARAM------------STNTMVL--------------TS---IKGTPLYMSPELVE------ERPYDHTADLWSVGCILYELAV-GT--------------PP---------------FYAT--------SIFQLV----SL----ILK---DPVRWPSTIS-----------------------------------------PCFKN-FLQGLLTKDPRQRLS-----WP-DLLYHPFI--------------
-------YELQEVIGSGATAVV---QAALCK----------------PRQE---RVAIKRINLE--KCQTSM---D-E-LLK--EIQAMSQC--S---HPNVVTYYTSFV--V------KDELWLVMKLLSGGSMLDIIKYIVNRGEHKNG----------------------------------------------------------------------------------------------------VLEEAIIATILKEVLEGLDYLHRN--------GQIHRDLKAGNILLG--E---DGSVQIADFGVSAFLAT-------GGDVTRNKVR--------------KT---FVGTPCWMAPEVME-----QVRGYDFKADMWSFGITAIELAT-GA--------------AP---------------YHKY-----PPMKVLMLT----LQ----NDP---PTLETGVEDKE--MMK--------------------------------KYGKSFRK-LLSLCLQKDPSKRPT-----AA-ELLKCKFF--------------
----TLE---DKELGSGNFGTV---KKGYYQ--------------MKKVVK---TVAVKILK-N--EAN-DPALKD-ELL-A--EANVMQQL--D---NPYIVRMIGICE---------AESWMLVMEMAELGPLNKYLQ---------QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEES--------NFVHRDLAARNVLLV--T---QHYAKISDFGLSKAL------R-----A--DENY-------------YKAQTHGKWPVKWYAPECIN------YYKFSSKSDVWSFGVLMWEAFSYGQ--------------KP---------------YRGM-----KGSEVTAML----EK----GER---MGCPAGCP-------------------------------------------REMYD-LMNLCWTYDVENRPG-----FA-AVE----LRL------------
-------LTFMRELGSGLFGVV---RLGKWR-----------------AQY---KVAIKAIR-E--GAM-CE---E-DFI-E--EAKVMMKL--T---HPKLVQLYGVCT--Q------QKPIYIVTEFMERGCLLNFLR---------QR--------------------------------------------------------------------------------------------------QGHFSRDVLLSMCQDVCEGMEYLERN--------SFIHRDLAARNCLVS--E---AGVVKVSDFGMARYV------------L--DDQY--------------TSSSGAKFPVKWCPPEVFN------YSRFSSKSDVWSFGVLMWEVFTEGR--------------MP---------------FEKY-----TNYEVVTMV----TR----GHR---LYQPKLAS-------------------------------------------NYVYE-VMLRCWQEKPEGRPS-----FE-DLLRT--I--------------
------L-RLLEKLGDGSFGVV---RRGEWD-------------APSGKTV---SVAVKCLK-PDVLSQ-PEA-MD-DFI-R--EVNAMHSL--D---HRNLIRLYGVVL---------TPPMKMVTELAPLGSLLDRLR---------KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK--------RFIHRDLAARNLLLA--T---RDLVKIGDFGLMRAL-----PQ-----N--DDHY--------------VMQEHRKVPFAWCAPESLK------TRTFSHASDTWMFGVTLWEMFTYGQ--------------EP---------------WIGL-----NGSQILHKI---DKE----GER---LPRPEDCP-------------------------------------------QDIYN-VMVQCWAHKPEDRPT-----FV-ALRDF--L--------------
------L-AFIKEIGSGQFGVV---HLGEWR-----------------SHI---QVAIKAIN-E--GSM-SE---E-DFI-E--EAKVMMKL--S---HSKLVQLYGVCI--Q------RKPLYIVTEFMENGCLLNYLR---------EN--------------------------------------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLERN--------GYIHRDLAARNCLVS--S---TCIVKISDFGMTRYV------------L--DDEY--------------VSSFGAKFPIKWSPPEVFL------FNKYSSKSDVWSFGVLMWEVFTEGK--------------MP---------------FENK-----SNLQVVEAI----SE----GFR---LYRPHLAP-------------------------------------------MSIYE-VMYSCWHEKPEGRPT-----FA-ELLR---AV-------------
------L-KKIRDLGEGHFGKV---SLYCYDP------------TNDGTGE---MVAVKALK-A--DCG-PQH-RS-GWK-Q--EIDILRTL--Y---HEHIIKYKGCCEDQG------EKSLQLVMEYVPLGSLRDYLP---------RH----------------------------------------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHAQ--------HYIHRDLAARNVLLD--N---DRLVKIGDFGLAKAV-----PE-----G--HEYY--------------RVREDGDSPVFWYAPECLK------EYKFYYASDVWSFGVTLYELLTHCD--------------SSQSPPTKF-LELIGIAQGQM-----TVLRLTELL----ER----GER---LPRPDKCP-------------------------------------------CEVYH-LMKNCWETEASFRPT-----FE-NLIP---IL-------------
-----FI--LTERLGSGTYATV---YKAYAKK---------------DTRE---VVAIKCVAKK--SLNKAS---V-ENLLT--EIEILKGI--R---HPHIVQLKDFQW--D------SDNIYLIMEFCAGGDLSRFIH--------TRR----------------------------------------------------------------------------------------------------ILPEKVARVFMQQLASALQFLHER--------NISHLDLKPQNILLSSLE---KPHLKLADFGFAQH-------------MSPWDEK--------------HV---LRGSPLYMAPEMVC------QRQYDARVDLWSMGVILYEALF-GQ--------------PP---------------FASR-----SFSELEEKI----RS----NRV---IELPLRPLLS-----------------------------------------RDCRD-LLQRLLERDPSRRIS-----FQ-DFFAHPWV--------------
------L-RLEVKLGQGCFGEV---WMGTWN-----------------GTT---KVAIKTLK-P--GTM-MP---E-AFL-Q--EAQIMKKL--R---HDKLVPLYAVVS---------EEPIYIVTEFMSKGSLLDFLK---------EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERM--------NYIHRDLRAANILVG--E---NLVCKIADFGLARLI------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILQTELVTKGR--------------VP---------------YPGM-----VNREVLEQV----ER----GYR---MPCPQGCP-------------------------------------------ESLHE-LMNLCWKKDPDERPT-----FE-YIQSFL----------------
---LIAD----IELGCGNFGSV---RQGVYR--------------MRKKQI---DVAIKVLK-Q--GTE-KAD-TE-EMM-R--EAQIMHQL--D---NPYIVRLIGVCQ---------AEALMLVMEMAGGGPLHKFLV---------GK--------------------------------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEK--------NFVHRDLAARNVLLV--N---RHYAKISDFGLSKAL-----GA-----D--DSYY--------------TARSAGKWPLKWYAPECIN------FRKFSSRSDVWSYGVTMWEALSYGQ--------------KP---------------YKKM-----KGPEVMAFI----EQ----GKR---MECPPECP-------------------------------------------PELYA-LMSDCWIYKWEDRPD-----FL-TVEQR--M--------------
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