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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK DDR1 203
TK ABL1 261
TK ABL2 288
TKL ACVR1 208
TK ALK 1116
Other AURKA 133
Other AURKC 43
TK BLK 241
TKL BRAF 456
TK BTK 402
CMGC CDC2L5 705
CMGC CDK5 4
CMGC CDKL2 4
TK CSF1R 582
TK CSK 195
TK DDR2 563
TK EGFR 712
TK EPHA1 624
TK EPHA2 613
TK EPHA3 621
TK EPHA4 621
TK EPHA5 675
TK EPHA6 631
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB4 615
TK EPHB6 670
TK FGFR1 478
TK FGFR2 481
TK FRK 234
TK IGF1R 999
TK INSR 1023
TK JAK2 849
TK KIT 589
TK LCK 245
TK LTK 510
TK LYN 247
CMGC MAPK14 24
TK MUSK 575
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
TK PDGFRA 593
TK PDGFRB 600
Other PLK2 82
Other PLK3 62
AGC PRKCB 342
TK PTK2B 425
TKL RAF1 349
TK RET 724
TK SRC 270
TK SYK 371
TK TNK2 150
TK YES1 277
-------LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR-P--D-AT-KNA-RNDFL-K-EVKIMSRL--KDPNIIRLLGVCV--Q----------DDPLCMITDYMENGDLNQFLS--AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATL--------NFVHRDLATRNCLVGE---NFTIKIADFGMSRNL----Y--A--GDYY--------------RVQGRAVLPIRWMAWECIL------MGK---FTTASDVWAFGVTLWEVLMLCRA---------QP---------------FGQL-----TDEQVIENAGEFFRD----QGRQ-VYLSRPPACP------------------------------QGLYE-LMLRCWSRESEQRPPFSQLHRFL----------------
-------ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTLK-E--D-TM-EV---EEFL-K-EAAVMKEI--KHPNLVQLLGVCT--R----------EPPFYIITEFMTYGNLLDYLR--EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGE---NHLVKVADFGLSRLM-------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNK---FSIKSDVWAFGVLLWEIATYGM----------SP---------------YPGI-----DLSQVYELL----EK----DYR----MERPEGCP------------------------------EKVYE-LMRACWQWNPSDRPSFAEIHQA--F--------------
-------ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTLK-E--D-TM-EV---EEFL-K-EAAVMKEI--KHPNLVQLLGVCT--L----------EPPFYIVTEYMPYGNLLDYLR--EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGE---NHVVKVADFGLSRLM-------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNT---FSIKSDVWAFGVLLWEIATYGM----------SP---------------YPGI-----DLSQVYDLL----EK----GYR----MEQPEGCP------------------------------PKVYE-LMRACWKWSPADRPSFAETHQA--F--------------
------I-TLLECVGKGRYGEVWRGSWQ----------------GEN--VAVKIFSSR--D-EKSWF---RET----ELYNTVML--RHENILGFIASDM--TSR------HSSTQLWLITHYHEMGSLYDYLQ--LT----------------------------------------------------------------------------------------------------TLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKK---NGQCCIADLGLAVMHSQ---STNQLDVGN--------------NP---RVGTKRYMAPEVLDETIQVDCFD---SYKRVDIWAFGLVLWEVAR-RMVSNGIVEDYKPP---------------FYDVVPNDPSFEDMRKVV----CV----DQQ----RPNIPNRWFSDPTL------------------------TSLAK-LMKECWYQNPSARLTALRIKK----TL------------
------I-TLIRGLGHGAFGEVYEGQVSG-----------MPNDPSPLQVAVKTLP-E--V-CS-EQD-ELDFL-M-EALIISKF--NHQNIVRCIGVSL--Q----------SLPRFILLELMAGGDLKSFLR--ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN--------HFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI----Y--R--ASYY--------------RKGGCAMLPVKWMPPEAFM------EGI---FTSKTDTWSFGVLLWEIFSLGY----------MP---------------YPSK-----SNQEVLEFV----TS----GGR----MDPPKNCP------------------------------GPVYR-IMTQCWQHQPEDRPNFAIILER--I--------------
-------FEIGRPLGKGKFGNVYLAREK----------------QSKFILALKVLFKA--QLEKAGV---EHQLRR-EVEIQSHL--RHPNILRLYGYFH--D----------ATRVYLILEYAPLGTVYRELQ-KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK--------RVIHRDIKPENLLLGS---AGELKIADFGWSV---------HAPSSRR--------------TT---LCGTLDYLPPEMIE------GRM---HDEKVDLWSLGVLCYEFLV-GK----------PP---------------FEAN--------TYQETY----KR----ISR----VEFTFPDFVT----------------------------EGARD-LISRLLKHNPSQRPMLREVLEHPWI--------------
-------FEIGRPLGKGKFGNVYLARLK----------------ESHFIVALKVLFKS--Q-IEKEG---LEHQLRREIEIQAHL--QHPNILRLYNYFH--D----------ARRVYLILEYAPRGELYKELQ-KSE----------------------------------------------------------------------------------------------------KLDEQRTATIIEELADALTYCHDK--------KVIHRDIKPENLLLGF---RGEVKIADFGWSV---------HTPSLRR--------------KT---MCGTLDYLPPEMIE------GRT---YDEKVDLWCIGVLCYELLV-GY----------PP---------------FESA--------SHSETY----RR----ILK----VDVRFPLSMP----------------------------LGARD-LISRLLRYQPLERLPLAQILKHPWV--------------
------L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAIKTLK-E--G-TM-SP---EAFL-G-EANVMKAL--QHERLVRLYAVVT-------------KEPIYIVTEYMARGCLLDFLK--TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERM--------NSIHRDLRAANILVSE---ALCCKIADFGLARII----------DSEY--------------TAQEGAKFPIKWTAPEAIH------FGV---FTIKADVWSFGVLLMEVVTYGR----------VP---------------YPGM-----SNPEVIRNL----ER----GYR----MPRPDTCP------------------------------PELYRGVIAECWRSRPEERPTFEFLQSV--L--------------
-------ITVGQRIGSGSFGTVYKGKWH-------------------GDVAVKMLN-V-TA-PT-PQQ-LQAFK-N-EVGVLRKT--RHVNILLFMGYST-------------KPQLAIVTQWCEGSSLYHHLH--II--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAK--------SIIHRDLKSNNIFLHE---DLTVKIGDFGLATVK----S--R--WSGS--------------HQFEQLSGSILWMAPEVIR------MQDKNPYSFQSDVYAFGIVLYELMT-GQ----------LP---------------YSNI-N---NRDQIIFMV----GR----GYLSPDLSKVRSNCP------------------------------KAMKR-LMAECLKKKRDERPLFPQILA---SI-------------
-------LTFLKELGTGQFGVVKYGKWR-----------------GQYDVAIKMIK-E--G-SM-SE---DEFI-E-EAKVMMNL--SHEKLVQLYGVCT--K----------QRPIFIITEYMANGCLLNYLR--EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESK--------QFLHRDLAARNCLVND---QGVVKVSDFGLSRYV-------L--DDEY--------------TSSVGSKFPVRWSPPEVLM------YSK---FSSKSDIWAFGVLMWEIYSLGK----------MP---------------YERF-----TNSETAEHI----AQ----GLR----LYRPHLAS------------------------------EKVYT-IMYSCWHEKADERPTFKILLSN--I--------------
------F-DIIGIIGEGTYGQVYKARDK----------------DTGEMVALKKVRLD--N-EKEGF---PITAIR-EIKILRQL--THQSIINMKEIVT--DKEDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLV----------------------------------------------------------------------------------------------------HFNENHIKSFMRQLMEGLDYCHKK--------NFLHRDIKCSNILLNN---RGQIKLADFGLARLY------SSEESRPY--------------TN---KVITLWYRPPELLL-----GEER---YTPAIDVWSCGCILGELFT-KK----------PI---------------FQAN-----QELAQLELI----SR----ICG----SPCPAVWPDVIKLPYFNTMKPKKQY-RRKLREEFVFIPAAALD-LFDYMLALDPSKRCTAEQALQCEF-L-------------
-------YEKLEKIGEGTYGTVFKAKNR----------------ETHEIVALKRVRLD--D-DDEGV---PSSALR-EICLLKEL--KHKNIVRLHDVLH--S----------DKKLTLVFEFCDQ-DLKKYFDSCNG----------------------------------------------------------------------------------------------------DLDPEIVKSFLFQLLKGLGFCHSR--------NVLHRDLKPQNLLINR---NGELKLADFGLARAF-------GIPVRCY--------------SA---EVVTLWYRPPDVLF-----GAKL---YSTSIDMWSAGCIFAELANAGR----------PL---------------FPGN-----DVDDQLKRI----FR----LLG----TPTEEQWPSMTKLPDYKPYPMYPAT--TSLVNVVPKLNATGRD-LLQNLLKCNPVQRISAEEALQHPYF--------------
-------YENLGLVGEGSYGMVMKCRNK----------------DTGRIVAIKKFLES--D-DDKMV---KKIAMR-EIKLLKQL--RHENLVNLLEVCK--K----------KKRWYLVFEFVDHTILDDLEL-FPN----------------------------------------------------------------------------------------------------GLDYQVVQKYLFQIINGIGFCHSH--------NIIHRDIKPENILVSQ---SGVVKLCDFGFARTL-------AAPGEVY--------------TD---YVATRWYRAPELLV-----GDVK---YGKAVDVWAIGCLVTEMFM-GE----------PL---------------FPGD-----SDIDQLYHI----MM----CLG----NLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVID-LAKKCLHIDPDKRPFCAELLHHDFF--------------
-------LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAVKMLK-S--T-AH-ADE-KEALM-S-ELKIMSHLG-QHENIVNLLGACT--H----------GGPVLVITEYCCYGDLLNFLR--RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASK--------NCIHRDVAARNVLLTN---GHVAKIGDFGLARDI----M--N--DSNY--------------IVKGNARLPVKWMAPESIF------DCV---YTVQSDVWSYGILLWEIFSLGL----------NP---------------YPGI-L---VNSKFYKLV----KD----GYQ----MAQPAFAP------------------------------KNIYS-IMQACWALEPTHRPTFQQICSFL----------------
-------LKLLQTIGKGEFGDVMLGDYR------------------GNKVAVKCIK-N--D-AT-AQ----AFL-A-EASVMTQL--RHSNLVQLLGVIV-EE----------KGGLYIVTEYMAKGSLVDYLR--SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGN--------NFVHRDLAARNVLVSE---DNVAKVSDFGLTKEA-------------S--------------STQDTGKLPVKWTAPEALR------EKK---FSTKSDVWSFGILLWEIYSFGR----------VP---------------YPRI-----PLKDVVPRV----EK----GYK----MDAPDGCP------------------------------PAVYE-VMKNCWHLDAAMRPSFLQLREQL----------------
-------LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR-A--D-AN-KNA-RNDFL-K-EIKIMSRL--KDPNIIHLLAVCI--T----------DDPLCMITEYMENGDLNQFLS--RHEPPN-----------------------------------------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSSL--------NFVHRDLATRNCLVGK---NYTIKIADFGMSRNL----Y--S--GDYY--------------RIQGRAVLPIRWMSWESIL------LGK---FTTASDVWAFGVTLWETFTFCQE---------QP---------------YSQL-----SDEQVIENT----GEFFRDQGRQ-TYLPQPAICP------------------------------DSVYK-LMLSCWRRDTKNRPSFQEIHL---LL-------------
------F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKIPVAIKELR-E--A-TS-PKA-NKEIL-D-EAYVMASV--DNPHVCRLLGICL-------------TSTVQLITQLMPFGCLLDYVR--EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR--------RLVHRDLAARNVLVKT---PQHVKITDFGLAKLL----G--A--EEKE--------------YHAEGGKVPIKWMALESIL------HRI---YTHQSDVWSYGVTVWELMTFGS----------KP---------------YDGI-----PASEISSIL----EK----GER----LPQPPICT------------------------------IDVYM-IMVKCWMIDADSRPKFRELI----IEF------------
-----LM--VDTVIGEGEFGEVYRGTLR-------------LPSQDCKTVAIKTLK-D--T-SP-GGQ-WWNFL-R-EATIMGQF--SHPHILHLEGVVT--K----------RKPIMIITEFMENGALDAFLR--ER--------------------------------------------------------------------------------------------------EDQLVPGQLVAMLQGIASGMNYLSNH--------NYVHRDLAARNILVNQ---NLCCKVSDFGLTRLL----D--D--FDGT--------------YETQGGKIPIRWTAPEAIA------HRI---FTTASDVWSFGIVMWEVLSFGD----------KP---------------YGEM-----SNQEVMKSI----ED----GYR----LPPPVDCP------------------------------APLYE-LMKNCWAYDRARRPHFQKLQAHL----------------
------V-TRQKVIGAGEFGEVYKGMLKT------------SSGKKEVPVAIKTLK-A--G-YT-EKQ-RVDFL-G-EAGIMGQF--SHHNIIRLEGVIS--K----------YKPMMIITEYMENGALDKFLR--EK--------------------------------------------------------------------------------------------------DGEFSVLQLVGMLRGIAAGMKYLANM--------NYVHRDLAARNILVNS---NLVCKVSDFGLSRVL----E--D--DPEA-------------TYTTSGGKIPIRWTAPEAIS------YRK---FTSASDVWSFGIVMWEVMTYGE----------RP---------------YWEL-----SNHEVMKAI----ND----GFR----LPTPMDCP------------------------------SAIYQ-LMMQCWQQERARRPKFADIVSIL----------------
------I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEISVAIKTLK-V--G-YT-EKQ-RRDFL-G-EASIMGQF--DHPNIIRLEGVVT--K----------SKPVMIVTEYMENGSLDSFLR--KH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDM--------GYVHRDLAARNILINS---NLVCKVSDFGLSRVL----E--D--DPEA-------------AYTTRGGKIPIRWTSPEAIA------YRK---FTSASDVWSYGIVLWEVMSYGE----------RP---------------YWEM-----SNQDVIKAV----DE----GYR----LPPPMDCP------------------------------AALYQ-LMLDCWQKDRNNRPKFEQIVSIL----------------
-------IKIEKVIGVGEFGEVCSGRLK-------------VPGKREICVAIKTLK-A--G-YT-DKQ-RRDFL-S-EASIMGQF--DHPNIIHLEGVVT--K----------CKPVMIITEYMENGSLDAFLR--KN--------------------------------------------------------------------------------------------------DGRFTVIQLVGMLRGIGSGMKYLSDM--------SYVHRDLAARNILVNS---NLVCKVSDFGMSRVL----E--D--DPEA-------------AYTTRGGKIPIRWTAPEAIA------YRK---FTSASDVWSYGIVMWEVMSYGE----------RP---------------YWDM-----SNQDVIKAI----EE----GYR----LPPPMDCP------------------------------IALHQ-LMLDCWQKERSDRPKFGQIVNML----------------
-------ITIERVIGAGEFGEVCSGRLK-------------LPGKRELPVAIKTLK-V--G-YT-EKQ-RRDFL-G-EASIMGQF--DHPNIIHLEGVVT--K----------SKPVMIVTEYMENGSLDTFLK--KN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGISAGMKYLSDM--------GYVHRDLAARNILINS---NLVCKVSDFGLSRVL----E--D--DPEA-------------AYTTRGGKIPIRWTAPEAIA------FRK---FTSASDVWSYGIVMWEVVSYGE----------RP---------------YWEM-----TNQDVIKAV----EE----GYR----LPSPMDCP------------------------------AALYQ-LMLDCWQKERNSRPKFDEIVNML----------------
LPPRIPA----------------------------------------------------------------------------------------------------------GRPVMIVVEYMENGSLDSFLR--KH--------------------------------------------------------------------------------------------------DGHFTVIQLVGMLRGIASGMKYLSDM--------GYVHRDLAARNILVNS---NLVCKVSDFGLSRVL----E--D--DPEA-------------AYTTTGGKIPIRWTAPEAIA------YRK---FSSASDAWSYGIVMWEVMSYGE----------RP---------------YWEM-----SNQDVILSI----EE----GYR----LPAPMGCP------------------------------ASLHQ-LMLHCWQKERNHRPKFTDIVSFL----------------
-------IHIEKIIGSGDSGEVCYGRLR-------------VPGQRDVPVAIKALK-A--G-YT-ERQ-RRDFL-S-EASIMGQF--DHPNIIRLEGVVT--R----------GRLAMIVTEYMENGSLDTFLR--TH--------------------------------------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSDL--------GYVHRDLAARNVLVDS---NLVCKVSDFGLSRVL----E--D--DPDA-------------AYTTTGGKIPIRWTAPEAIA------FRT---FSSASDVWSFGVVMWEVLAYGE----------RP---------------YWNM-----TNRDVISSV----EE----GYR----LPAPMGCP------------------------------HALHQ-LMLDCWHKDRAQRPRFSQIVSVL----------------
------V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREIYVAIKTLK-A--G-YS-EKQ-RRDFL-S-EASIMGQF--DHPNIIRLEGVVT--K----------SRPVMIITEFMENGALDSFLR--QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEM--------NYVHRDLAARNILVNS---NLVCKVSDFGLSRYLQ-DDT--S--DPTY--------------TSSLGGKIPVRWTAPEAIA------YRK---FTSASDVWSYGIVMWEVMSFGE----------RP---------------YWDM-----SNQDVINAI----EQ----DYR----LPPPMDCP------------------------------AALHQ-LMLDCWQKDRNSRPRFAEIVNTL----------------
------V-KIEQVIGAGEFGEVCSGHLK-------------LPGKREIFVAIKTLK-S--G-YT-EKQ-RRDFL-S-EASIMGQF--DHPNVIHLEGVVT--K----------STPVMIITEFMENGSLDSFLR--QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADM--------NYVHRDLAARNILVNS---NLVCKVSDFGLSRFLE-DDT--S--DPTY--------------TSALGGKIPIRWTAPEAIQ------YRK---FTSASDVWSYGIVMWEVMSYGE----------RP---------------YWDM-----TNQDVINAI----EQ----DYR----LPPPMDCP------------------------------SALHQ-LMLDCWQKDRNHRPKFGQIVNTL----------------
------V-KIEEVIGAGEFGEVCRGRLK-------------APGKKESCVAIKTLK-G--G-YT-ERQ-RREFL-S-EASIMGQF--EHPNIIRLEGVVT--N----------SMPVMILTEFMENGALDSFLR--LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEM--------SYVHRDLAARNILVNS---NLVCKVSDFGLSRFLE-ENS--S--DPTY--------------TSSLGGKIPIRWTAPEAIA------FRK---FTSASDAWSYGIVMWEVMSFGE----------RP---------------YWDM-----SNQDVINAI----EQ----DYR----LPPPPDCP------------------------------TSLHQ-LMLDCWQKDRNARPRFPQVVSAL----------------
-------IKIEEVIGTGSFGEVRQGRLQ-------------PRGRREQTVAIQALW-A--G-GA-ESL-QMTFL-G-RAAVLGQF--QHPNILRLEGVVT--K----------SRPLMVLTEFMELGPLDSFLR--QR--------------------------------------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSF--------AFVHRSLSAHSVLVNS---HLVCKVARLGHSPQG---------------------------------PSCLLRWAAPEVIA------HGK---HTTSSDVWSFGILMWEVMSYGE----------RP---------------YWDM-----SEQEVLNAI----EQ----EFR----LPPPPGCP------------------------------PGLHL-LMLDTWQKDRARRPHFDQLVA---AF-------------
------L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKMLK-S--D-AT-EKD-LSDLI-S-EMEMMKMIG-KHKNIINLLGACT--Q----------DGPLYVIVEYASKGNLREYLQ--ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--------KCIHRDLAARNVLVTE---DNVMKIADFGLARDI----H--H--IDYY--------------KKTTNGRLPVKWMAPEALF------DRI---YTHQSDVWSFGVLLWEIFTLGG----------SP---------------YPGV-----PVEELFKLL----KE----GHR----MDKPSNCT------------------------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL----------------
-------LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAVKMLK-D--D-AT-EKD-LSDLV-S-EMEMMKMIG-KHKNIINLLGACT--Q----------DGPLYVIVEYASKGNLREYLR--ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ--------KCIHRDLAARNVLVTE---NNVMKIADFGLARDI----N--N--IDYY--------------KKTTNGRLPVKWMAPEALF------DRV---YTHQSDVWSFGVLMWEIFTLGG----------SP---------------YPGI-----PVEELFKLL----KE----GHR----MDKPANCT------------------------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL----------------
-------IQLLKRLGSGQFGEVWEGLWN-----------------NTTPVAVKTLK-P--G-SM-DP---NDFL-R-EAQIMKNL--RHPKLIQLYAVCT--L----------EDPIYIITELMRHGSLQEYLQ--ND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESR--------NYIHRDLAARNVLVGE---HNIYKVADFGLARVFK--VD--N--EDIY--------------ESRHEIKLPVKWTAPEAIR------SNK---FSIKSDVWSFGILLYEIITYGK----------MP---------------YSGM-----TGAQVIQML----AQ----NYR----LPQPSNCP------------------------------QQFYN-IMLECWNAEPKERPTFETLRWK--L--------------
-------ITMSRELGQGSFGMVYEGVAKG-----------VVKDEPETRVAIKTVN-E--A-AS-MRE-RIEFL-N-EASVMKEF--NCHHVVRLLGVVS--Q----------GQPTLVIMELMTRGDLKSYLR--SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNAN--------KFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI----Y--E--TDYY--------------RKGGKGLLPVRWMSPESLK------DGV---FTTYSDVWSFGVVLWEIATLAE----------QP---------------YQGL-----SNEQVLRFV----ME----GGL----LDKPDNCP------------------------------DMLFE-LMRMCWQYNPKMRPSFLEIISS--I--------------
-------ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAVKTVN-E--S-AS-LRE-RIEFL-N-EASVMKGF--TCHHVVRLLGVVS--K----------GQPTLVVMELMAHGDLKSYLR--SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK--------KFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI----Y--E--TDYY--------------RKGGKGLLPVRWMAPESLK------DGV---FTTSSDMWSFGVVLWEITSLAE----------QP---------------YQGL-----SNEQVLKFV----MD----GGY----LDQPDNCP------------------------------ERVTD-LMRMCWQFNPKMRPTFLEIVNLL----------------
-------LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAVKKLQ-H--S-TE--EH-LRDFE-R-EIEILKSL--QHDNIVKYKGVCYSAG----------RRNLKLIMEYLPYGSLRDYLQ--KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK--------RYIHRDLATRNILVEN---ENRVKIGDFGLTKVL---PQ--D--KEYY--------------KVKEPGESPIFWYAPESLT------ESK---FSVASDVWSFGVVLYELFTYIE----------KSKSPPAEFMRMIGNDKQGQM-----IVFHLIELL----KN----NGR----LPRPDGCP------------------------------DEIYM-IMTECWNNNVNQRPSFRDLA----LRV------------
-------LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAVKMLK-P--S-AH-LTE-REALM-S-ELKVLSYLG-NHMNIVNLLGACT--I----------GGPTLVITEYCCYGDLLNFLR--RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK--------NCIHRDLAARNILLTH---GRITKICDFGLARDI----K--N--DSNY--------------VVKGNARLPVKWMAPESIF------NCV---YTFESDVWSYGIFLWELFSLGS----------SP---------------YPGM-P---VDSKFYKMI----KE----GFR----MLSPEHAP------------------------------AEMYD-IMKTCWDADPLKRPTFKQIVQL--I--------------
-------LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSLK-Q--G-SM-SP---DAFL-A-EANLMKQL--QHQRLVRLYAVVT-------------QEPIYIITEYMENGSLVDFLK--TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVSD---TLSCKIADFGLARLI-------E--DNEY--------------TAREGAKFPIKWTAPEAIN------YGT---FTIKSDVWSFGILLTEIVTHGR----------IP---------------YPGM-----TNPEVIQNL----ER----GYR----MVRPDNCP------------------------------EELYQ-LMRLCWKERPEDRPTFDYLRSV--L--------------
------V-TLLRALGHGAFGEVYEGLVIG-----------LPGDSSPLQVAIKTLP-E--L-CS-PQD-ELDFL-M-EALIISKF--RHQNIVRCVGLSL--R----------ATPRLILLELMSGGDMKSFLR--HSRP--------------------------------------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEEN--------HFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDI----Y--R--ASYY--------------RRGDRALLPVKWMPPEAFL------EGI---FTSKTDSWSFGVLLWEIFSLGY----------MP---------------YPGR-----TNQEVLDFV----VG----GGR----MDPPRGCP------------------------------GPVYR-IMTQCWQHEPELRPSFASILERL----------------
-------IKLVKRLGAGQFGEVWMGYYN-----------------NSTKVAVKTLK-P--G-TM-SV---QAFL-E-EANLMKTL--QHDKLVRLYAVVT--R----------EEPIYIITEYMAKGSLLDFLK--SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERK--------NYIHRDLRAANVLVSE---SLMCKIADFGLARVI-------E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGC---FTIKSDVWSFGILLYEIVTYGK----------IP---------------YPGR-----TNADVMTAL----SQ----GYR----MPRVENCP------------------------------DELYD-IMKMCWKEKAEERPTFDYLQSV--L--------------
-------YQNLSPVGSGAYGSVCAAFDT----------------KTGLRVAVKKLSRP--F-QSIIH---AKRTYR-ELRLLKHM--KHENVIGLLDVFT--PARS----LEEFNDVYLVTHLMGA-DLNNIVK--CQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSA--------DIIHRDLKPSNLAVNE---DCELKILDFGLAR----------HTDDEM--------------TG---YVATRWYRAPEIML-----NWMH---YNQTVDIWSVGCIMAELLT-GR----------TL---------------FPGT-----DHIDQLKLI----LR----LVG----TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVD-LLEKMLVLDSDKRITAAQALAHAYF--------------
------I-EYVRDIGEGAFGRVFQARAPG-----------LLPYEPFTMVAVKMLK-E--E-AS-ADM-QADFQ-R-EAALMAEF--DNPNIVKLLGVCA--V----------GKPMCLLFEYMAYGDLNEFLR--SMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSER--------KFVHRDLATRNCLVGE---NMVVKIADFGLSRNI----Y--S--ADYY--------------KANENDAIPIRWMPPESIF------YNR---YTTESDVWAYGVVLWEIFSYGL----------QP---------------YYGM-----AHEEVIYYV----RD----GNI----LSCPENCP------------------------------VELYN-LMRLCWSKLPADRPSFTSIHRIL----------------
-----IV--LKWELGEGAFGKVFLAECHN-----------LLPEQDKMLVAVKALK-E--A-SE-SA--RQDFQ-R-EAELLTML--QHQHIVRFFGVCT--E----------GRPLLMVFEYMRHGDLNRFLR--SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGL--------HFVHRDLATRNCLVGQ---GLVVKIGDFGMSRDI----Y--S--TDYY--------------RVGGRTMLPIRWMPPESIL------YRK---FTTESDVWSFGVVLWEIFTYGK----------QP---------------WYQL-----SNTEAIDCI----TQ----GRE----LERPRACP------------------------------PEVYA-IMRGCWQREPQQRHSIKDVHARL----------------
------I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKILVAVKTLK-D--A-SD-NA--RKDFH-R-EAELLTNL--QHEHIVKFYGVCV--E----------GDPLIMVFEYMKHGDLNKFLR--AHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQ--------HFVHRDLATRNCLVGE---NLLVKIGDFGMSRDV----Y--S--TDYY--------------RVGGHTMLPIRWMPPESIM------YRK---FTTESDVWSLGVVLWEIFTYGK----------QP---------------WYQL-----SNNEVIECI----TQ----GRV----LQRPRTCP------------------------------QEVYE-LMLGCWQREPHMRKNIKGIHTL--L--------------
------I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKMLVAVKALK-D--P-TL-AA--RKDFQ-R-EAELLTNL--QHEHIVKFYGVCG--D----------GDPLIMVFEYMKHGDLNKFLR--AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQ--------HFVHRDLATRNCLVGA---NLLVKIGDFGMSRDV----Y--S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM------YRK---FTTESDVWSFGVILWEIFTYGK----------QP---------------WFQL-----SNTEVIECI----TQ----GRV----LERPRVCP------------------------------KEVYD-VMLGCWQREPQQRLNIKEIYKIL----------------
------L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAVKMLK-P--T-AR-SSE-KQALM-S-ELKIMTHLG-PHLNIVNLLGACT--K----------SGPIYIITEYCFYGDLVNYLH--KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASK--------NCVHRDLAARNVLLAQ---GKIVKICDFGLARDI----M--H--DSNY--------------VSKGSTFLPVKWMAPESIF------DNL---YTTLSDVWSYGILLWEIFSLGG----------TP---------------YPGM-M---VDSTFYNKI----KS----GYR----MAKPDHAT------------------------------SEVYE-IMVKCWNSEPEKRPSFYHLSE---IV-------------
------L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAVKMLK-S--T-AR-SSE-KQALM-S-ELKIMSHLG-PHLNVVNLLGACT--K----------GGPIYIITEYCRYGDLVDYLH--RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASK--------NCVHRDLAARNVLICE---GKLVKICDFGLARDI----M--R--DSNY--------------ISKGSTFLPLKWMAPESIF------NSL---YTTLSDVWSFGILLWEIFTLGG----------TP---------------YPEL-P---MNEQFYNAI----KR----GYR----MAQPAHAS------------------------------DEIYE-IMQKCWEEKFEIRPPFSQLVL---LL-------------
------Y-CRGKVLGKGGFAKCYEMTDL----------------TNNKVYAAKIIPHS--R-VAKPH---QREKIDKEIELHRIL--HHKHVVQFYHYFE--D----------KENIYILLEYCSRRSMAHILK-ARK----------------------------------------------------------------------------------------------------VLTEPEVRYYLRQIVSGLKYLHEQ--------EILHRDLKLGNFFINE---AMELKVGDFGLAARL-------EPLEHRR--------------RT---ICGTPNYLSPEVLN------KQG---HGCESDIWALGCVMYTMLL-GR----------PP---------------FETT--------NLKETY----RC----IRE----ARYTMPSSLL----------------------------APAKH-LIASMLSKNPEDRPSLDDIIRHDFF--------------
-----YL--KGRLLGKGGFARCYEATDT----------------ETGSAYAVKVIPQS--R-VAKPH---QREKILNEIELHRDL--QHRHIVRFSHHFE--D----------ADNIYIFLELCSRKSLAHIWK-ARH----------------------------------------------------------------------------------------------------TLLEPEVRYYLRQILSGLKYLHQR--------GILHRDLKLGNFFITE---NMELKVGDFGLAARL-------EPPEQRK--------------KT---ICGTPNYVAPEVLL------RQG---HGPEADVWSLGCVMYTLLC-GS----------PP---------------FETA--------DLKETY----RC----IKQ----VHYTLPASLS----------------------------LPARQ-LLAAILRASPRDRPSIDQILRHDFF--------------
------F-NFLMVLGKGSFGKVMLSERK----------------GTDELYAVKILKKD--V-VIQDD---DVECTMVEKRVLALP-GKPPFLTQLHSCFQ--T----------MDRLYFVMEYVNGGDLMYHIQ-QVG----------------------------------------------------------------------------------------------------RFKEPHAVFYAAEIAIGLFFLQSK--------GIIYRDLKLDNVMLDS---EGHIKIADFGMCKEN-------IWDGVTT--------------KT---FCGTPDYIAPEIIA------YQP---YGKSVDWWAFGVLLYEMLA-GQ----------AP---------------FEGE--------DEDELF----QS----IME----HNVAYPKSMS----------------------------KEAVA-ICKGLMTKHPGKRLGC---------GPEGERDIKEHAFF
------V-VLNRILGEGFFGEVYEGVYT-------------NHKGEKINVAVKTCK-K--D-CT-LDN-KEKFM-S-EAVIMKNL--DHPHIVKLIGIIE-------------EEPTWIIMELYPYGELGHYLE--RN--------------------------------------------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESI--------NCVHRDIAVRNILVAS---PECVKLGDFGLSRYI-------E--DEDY--------------YKASVTRLPIKWMSPESIN------FRR---FTTASDVWMFAVCMWEILSFGK----------QP---------------FFWL-----ENKDVIGVL----EK----GDR----LPKPDLCP------------------------------PVLYT-LMTRCWDYDPSDRPRFTELVCS--L--------------
-----VM--LSTRIGSGSFGTVYKGKWH-------------------GDVAVKILK-V-VD-PT-PEQ-FQAFR-N-EVAVLRKT--RHVNILLFMGYMT-------------KDNLAIVTQWCEGSSLYKHLH--VQ--------------------------------------------------------------------------------------------------ETKFQMFQLIDIARQTAQGMDYLHAK--------NIIHRDMKSNNIFLHE---GLTVKIGDFGLATVK----S--R--WSGS--------------QQVEQPTGSVLWMAPEVIR------MQDNNPFSFQSDVYSYGIVLYELMT-GE----------LP---------------YSHI-N---NRDQIIFMV----GR----GYASPDLSKLYKNCP------------------------------KAMKR-LVADCVKKVKEERPLFPQILSS--I--------------
------L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYTTVAVKMLK-E--N-AS-PSE-LRDLL-S-EFNVLKQV--NHPHVIKLYGACS--Q----------DGPLLLIVEYAKYGSLRGFLR--ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM--------KLVHRDLAARNILVAE---GRKMKISDFGLSRDV----Y--E--EDSY--------------VKRSQGRIPVKWMAIESLF------DHI---YTTQSDVWSFGVLLWEIVTLGG----------NP---------------YPGI-----PPERLFNLL----KT----GHR----MERPDNCS------------------------------EEMYR-LMLQCWKQEPDKRPVFADISKDL----------------
------L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAIKTLK-P--G-TM-SP---EAFL-Q-EAQVMKKL--RHEKLVQLYAVVS-------------EEPIYIVTEYMSKGSLLDFLK--GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVGE---NLVCKVADFGLARLI-------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELTTKGR----------VP---------------YPGM-----VNREVLDQV----ER----GYR----MPCPPECP------------------------------ESLHD-LMCQCWRKEPEERPTFEYLQAF--L--------------
----TLE---DKELGSGNFGTVKKGYYQ--------------MKKVVKTVAVKILK-N--E-AN-DPALKDELL-A-EANVMQQL--DNPYIVRMIGICE-------------AESWMLVMEMAELGPLNKYLQ--QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEES--------NFVHRDLAARNVLLVT---QHYAKISDFGLSKAL----R--A--DENY-------------YKAQTHGKWPVKWYAPECIN------YYK---FSSKSDVWSFGVLMWEAFSYGQ----------KP---------------YRGM-----KGSEVTAML----EK----GER----MGCPAGCP------------------------------REMYD-LMNLCWTYDVENRPGFAAVE----LRL------------
------L-RLLEKLGDGSFGVVRRGEWD-------------APSGKTVSVAVKCLK-PDVL-SQ-PEA-MDDFI-R-EVNAMHSL--DHRNLIRLYGVVL-------------TPPMKMVTELAPLGSLLDRLR--KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK--------RFIHRDLAARNLLLAT---RDLVKIGDFGLMRAL---PQ--N--DDHY--------------VMQEHRKVPFAWCAPESLK------TRT---FSHASDTWMFGVTLWEMFTYGQ----------EP---------------WIGL-----NGSQILHKI---DKE----GER----LPRPEDCP------------------------------QDIYN-VMVQCWAHKPEDRPTFVALRDF--L--------------
------L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAIKTLK-P--G-TM-MP---EAFL-Q-EAQIMKKL--RHDKLVPLYAVVS-------------EEPIYIVTEFMSKGSLLDFLK--EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERM--------NYIHRDLRAANILVGE---NLVCKIADFGLARLI-------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILQTELVTKGR----------VP---------------YPGM-----VNREVLEQV----ER----GYR----MPCPQGCP------------------------------ESLHE-LMNLCWKKDPDERPTFEYIQSFL----------------
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