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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK DDR1 203
TK ABL1 261
TK ABL2 288
TKL BRAF 456
TK FGFR1 478
TK FLT1 827
TK FLT4 845
TK KDR 834
TK KIT 589
TK LCK 245
TK MET 1078
TK PDGFRA 593
TK PDGFRB 600
TK PTK2B 425
TK TEK 824
-LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRP-DATKNARNDFLKEVKIMSRL-KDPNIIRLLGVCV-QDDPLCMITDYMENGDLNQFLSAHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYY--RVQGRAVLPIRWMAWECILMGK---FTTASDVWAFGVTLWEVLMLCRAQPFGQL-TDEQVIENAGEFFRDQGRQ-VYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL--
-ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTLKE-DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-REPPFYIITEFMTYGNLLDYLREC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-TGDTY--TAHAGAKFPIKWTAPESLAYNK---FSIKSDVWAFGVLLWEIATYGM-SPYPGI-DLSQVYELL----EKDYR----MERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F-
-ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTLKE-DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-LEPPFYIVTEYMPYGNLLDYLREC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM-TGDTY--TAHAGAKFPIKWTAPESLAYNT---FSIKSDVWAFGVLLWEIATYGM-SPYPGI-DLSQVYDLL----EKGYR----MEQPEGCPPKVYELMRACWKWSPADRPSFAETHQA-F-
-ITVGQRIGSGSFGTVYKGKWH-------------------GDVAVKMLNVTAPTPQQLQAFKNEVGVLRKT-RHVNILLFMGYST--KPQLAIVTQWCEGSSLYHHLHII--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGS--HQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQ-LPYSNINNRDQIIFMV----GRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA--SI
L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKMLKS-DATEKDLSDLISEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNLREYLQARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY--KKTTNGRLPVKWMAPEALFDRI---YTHQSDVWSFGVLLWEIFTLGG-SPYPGV-PVEELFKLL----KEGHR----MDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL--
-LKLGKSLGRGAFGKVVQASAFG-----------IKKSPTCRTVAVKMLKE-GATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPR--------------------------------LDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDY--VRKGDTRLPLKWMAPESIFDKI---YSTKSDVWSYGVLLWEIFSLGG-SPYPGVQMDEDFCSRL----REGMR----MRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL--
-LHLGRVLGYGAFGKVVEASAFG-----------IHKGSSCDTVAVKMLKE-GATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDY--VRKGSARLPLKWMAPESIFDKV---YTTQSDVWSFGVLLWEIFSLGA-SPYPGVQINEEFCQRL----RDGTR----MRAPELATPAIRRIMLNCWSGDPKARPAFSELVEIL--
-LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAVKMLKE-GATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDY--VRKGDARLPLKWMAPETIFDRV---YTIQSDVWSFGVLLWEIFSLGA-SPYPGVKIDEEFCRRL----KEGTR----MRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL--
-LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAVKMLKP-SAHLTEREALMSELKVLSYLGNHMNIVNLLGACT-IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNY--VVKGNARLPVKWMAPESIFNCV---YTFESDVWSYGIFLWELFSLGS-SPYPGMPVDSKFYKMI----KEGFR----MLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQL-I-
-LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSLKQ-GSMSP--DAFLAEANLMKQL-QHQRLVRLYAVVT--QEPIYIITEYMENGSLVDFLKTP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI-EDNEY--TAREGAKFPIKWTAPEAINYGT---FTIKSDVWSFGILLTEIVTHGR-IPYPGM-TNPEVIQNL----ERGYR----MVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L-
-VHFNEVIGRGHFGCVYHGTLL-------------DNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDF-SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNE--------------------------------------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQK---FTTKSDVWSFGVLLWELMTRGA-PPYPDV-NTFDITVYL----LQGRR----LLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSR-I-
L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAVKMLKP-TARSSEKQALMSELKIMTHLGPHLNIVNLLGACT-KSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNY--VSKGSTFLPVKWMAPESIFDNL---YTTLSDVWSYGILLWEIFSLGG-TPYPGMMVDSTFYNKI----KSGYR----MAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE--IV
L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAVKMLKS-TARSSEKQALMSELKIMSHLGPHLNVVNLLGACT-KGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY--ISKGSTFLPLKWMAPESIFNSL---YTTLSDVWSFGILLWEIFTLGG-TPYPELPMNEQFYNAI----KRGYR----MAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVL--LL
V-VLNRILGEGFFGEVYEGVYT-------------NHKGEKINVAVKTCKK-DCTLDNKEKFMSEAVIMKNL-DHPHIVKLIGIIE--EEPTWIIMELYPYGELGHYLERN--------------------------------------------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYI-EDEDY--YKASVTRLPIKWMSPESINFRR---FTTASDVWMFAVCMWEILSFGK-QPFFWL-ENKDVIGVL----EKGDR----LPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCS-L-
-IKFQDVIGEGNFGQVLKARIK--------------KDGLRMDAAIKRMKE-YASKDDHRDFAGELEVLCKLGHHPNIINLLGACE-HRGYLYLAIEYAPHGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVY--VKKTMGRLPVRWMAIESLNYSV---YTTNSDVWSYGVLLWEIVSLGG-TPYCGM-TCAELYEKL----PQGYR----LEKPLNCDDEVYDLMRQCWREKPYERPSFAQILV--SL
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