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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK DDR1 203
TK ABL1 261
TK CSF1R 582
TK FGFR1 478
TK FGFR2 481
TK FLT4 845
TK KDR 834
TK KIT 589
TK LCK 245
TK MET 1078
TK PDGFRA 593
TK PDGFRB 600
-LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRL-KDPNIIRLLGVCV-QDDPLCMITDYMENGDLNQFLSAHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYY--RVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQL-TDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL--
-ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTLKEDTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-REPPFYIITEFMTYGNLLDYLREC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-TGDTY--TAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGM-SPYPGI-DLSQVYELL----EKDYR---MERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F-
-LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACT-HGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNY--IVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGL-NPYPGILVNSKFYKLV----KDGYQ---MAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFL--
L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNLREYLQARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY--KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGG-SPYPGV-PVEELFKLL----KEGHR---MDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL--
-LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNLREYLRARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY--KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGG-SPYPGI-PVEELFKLL----KEGHR---MDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL--
-LHLGRVLGYGAFGKVVEASAFG-----------IHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDY--VRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGA-SPYPGVQINEEFCQRL----RDGTR---MRAPELATPAIRRIMLNCWSGDPKARPAFSELVEIL--
-LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDY--VRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGA-SPYPGVKIDEEFCRRL----KEGTR---MRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL--
-LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACT-IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNY--VVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGS-SPYPGMPVDSKFYKMI----KEGFR---MLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQL-I-
-LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSLKQGSMSP--DAFLAEANLMKQL-QHQRLVRLYAVVT--QEPIYIITEYMENGSLVDFLKTP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI-EDNEY--TAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGR-IPYPGM-TNPEVIQNL----ERGYR---MVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L-
-VHFNEVIGRGHFGCVYHGTLL-------------DNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDF-SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNE--------------------------------------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGA-PPYPDV-NTFDITVYL----LQGRR---LLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSR-I-
L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACT-KSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNY--VSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGG-TPYPGMMVDSTFYNKI----KSGYR---MAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE--IV
L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACT-KGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY--ISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGG-TPYPELPMNEQFYNAI----KRGYR---MAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVL--LL
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