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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK DDR1 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
TK AXL 527
TK BLK 241
TKL BRAF 456
TK CSF1R 582
TK DDR2 563
TK EGFR 712
TK EPHA2 613
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK FGFR1 478
TK FGFR2 481
TK FLT4 845
TK IGF1R 999
TK INSR 1023
TK ITK 363
TK KDR 834
TK LTK 510
TKL MAP3K7 36
TK MERTK 587
TK MET 1078
TK MUSK 575
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
TK PTK2 422
TK RET 724
STE SLK 34
TK SRC 270
TK YES1 277
--LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR-P-DAT-KNARNDFLKEVKIMSRL-KDPNIIRLLGVCV-QDDP------LCMITDYMENGDLNQFLS--AHQLEDKAAE--------------------------------------------------GAPGDGQAAQG-PTISYPMLLHVAAQIASGMRYLATLN---FVHRDLATRNCLVGE---NF-TIKIADFGMSRNL---YA--GDYY--------------RVQGRAVLPIRWMAWECIL-----MGK---FTTASDVWAFGVTLWEVLMLCRAQPFGQL--TDEQVIENAGEFFRD----QGRQ-VYLSRPPACP--QGLYE-LMLRCWSRESEQRPPFSQLHRFL----
--ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTLK-E-DTM-EV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-REPP------FYIITEFMTYGNLLDYLR--EC-------------------------------------------------------------------NR-QEVNAVVLLYMATQISSAMEYLEKKN---FIHRDLAARNCLVGE---NH-LVKVADFGLSRLM----T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNK---FSIKSDVWAFGVLLWEIATYGM-SPYPGI--DLSQVYELL----EK----DYR----MERPEGCP--EKVYE-LMRACWQWNPSDRPSFAEIHQA--F--
--ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTLK-E-DTM-EV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-LEPP------FYIVTEYMPYGNLLDYLR--EC-------------------------------------------------------------------NR-EEVTAVVLLYMATQISSAMEYLEKKN---FIHRDLAARNCLVGE---NH-VVKVADFGLSRLM----T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNT---FSIKSDVWAFGVLLWEIATYGM-SPYPGI--DLSQVYDLL----EK----GYR----MEQPEGCP--PKVYE-LMRACWKWSPADRPSFAETHQA--F--
-I-TLIRGLGHGAFGEVYEGQVSG-----------MPNDPSPLQVAVKTLP-E-VCS-EQDELDFLMEALIISKF-NHQNIVRCIGVSL-QSLP------RFILLELMAGGDLKSFLR--ETRP--------------------------------------------------------------RPSQP-SSLAMLDLLHVARDIACGCQYLEENH---FIHRDIAARNCLLTCPGPGR-VAKIGDFGMARDI---YR--ASYY--------------RKGGCAMLPVKWMPPEAFM-----EGI---FTSKTDTWSFGVLLWEIFSLGY-MPYPSK--SNQEVLEFV----TS----GGR----MDPPKNCP--GPVYR-IMTQCWQHQPEDRPNFAIILER--I--
-V-ALGKTLGEGEFGAVMEGQLN--------------QDDSILKVAVKTMK-IAICT-RSELEDFLSEAVCMKEF-DHPNVMRLIGVCF-QGSERESFPAPVVILPFMKHGDLHSFLL--YSRL---------------------------------------------------------------GDQP-VYLPTQMLVKFMADIASGMEYLSTKR---FIHRDLAARNCMLNE---NM-SVCVADFGLSKKI---YN--GDYY--------------RQGRIAKMPVKWIAIESLA-----DRV---YTSKSDVWSFGVTMWEIATRGQ-TPYPGV--ENSEIYDYL----RQ----GNR----LKQPADCL--DGLYA-LMSRCWELNPQDRPSFTELREDL----
-L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAIKTLK-E-GTM-SP--EAFLGEANVMKAL-QHERLVRLYAVVT--KEP------IYIVTEYMARGCLLDFLK--TD-------------------------------------------------------------------EG-SRLSLPRLIDMSAQIAEGMAYIERMN---SIHRDLRAANILVSE---AL-CCKIADFGLARII-------DSEY--------------TAQEGAKFPIKWTAPEAIH-----FGV---FTIKADVWSFGVLLMEVVTYGR-VPYPGM--SNPEVIRNL----ER----GYR----MPRPDTCP--PELYRGVIAECWRSRPEERPTFEFLQSV--L--
--ITVGQRIGSGSFGTVYKGKWH-------------------GDVAVKMLN-VTAPT-PQQLQAFKNEVGVLRKT-RHVNILLFMGYST--KPQ------LAIVTQWCEGSSLYHHLH--II--------------------------------------------------------------------E-TKFEMIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHE---DL-TVKIGDFGLATVK---SR--WSGS--------------HQFEQLSGSILWMAPEVIR-----MQDKNPYSFQSDVYAFGIVLYELMT-GQ-LPYSNI-NNRDQIIFMV----GR----GYLSPDLSKVRSNCP--KAMKR-LMAECLKKKRDERPLFPQILA---SI-
--LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAVKMLK-S-TAH-ADEKEALMSELKIMSHLGQHENIVNLLGACT-HGGP------VLVITEYCCYGDLLNFLR--RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDG-RPLELRDLLHFSSQVAQGMAFLASKN---CIHRDVAARNVLLTN---GH-VAKIGDFGLARDI---MN--DSNY--------------IVKGNARLPVKWMAPESIF-----DCV---YTVQSDVWSYGILLWEIFSLGL-NPYPGI-LVNSKFYKLV----KD----GYQ----MAQPAFAP--KNIYS-IMQACWALEPTHRPTFQQICSFL----
--LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR-A-DAN-KNARNDFLKEIKIMSRL-KDPNIIHLLAVCI-TDDP------LCMITEYMENGDLNQFLS--RHEPPN-----------------------------------------------------------SSSSDV-RTVSYTNLKFMATQIASGMKYLSSLN---FVHRDLATRNCLVGK---NY-TIKIADFGMSRNL---YS--GDYY--------------RIQGRAVLPIRWMSWESIL-----LGK---FTTASDVWAFGVTLWETFTFCQEQPYSQL--SDEQVIENT----GEFFRDQGRQ-TYLPQPAICP--DSVYK-LMLSCWRRDTKNRPSFQEIHL---LL-
-F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKIPVAIKELR-E-ATS-PKANKEILDEAYVMASV-DNPHVCRLLGICL--TST------VQLITQLMPFGCLLDYVR--EH--------------------------------------------------------------------K-DNIGSQYLLNWCVQIAKGMNYLEDRR---LVHRDLAARNVLVKT---PQ-HVKITDFGLAKLL---GA--EEKE--------------YHAEGGKVPIKWMALESIL-----HRI---YTHQSDVWSYGVTVWELMTFGS-KPYDGI--PASEISSIL----EK----GER----LPQPPICT--IDVYM-IMVKCWMIDADSRPKFRELI----IEF
-V-TRQKVIGAGEFGEVYKGMLKT------------SSGKKEVPVAIKTLK-A-GYT-EKQRVDFLGEAGIMGQF-SHHNIIRLEGVIS-KYKP------MMIITEYMENGALDKFLR--EK--------------------------------------------------------------------D-GEFSVLQLVGMLRGIAAGMKYLANMN---YVHRDLAARNILVNS---NL-VCKVSDFGLSRVL---ED--DPEA-------------TYTTSGGKIPIRWTAPEAIS-----YRK---FTSASDVWSFGIVMWEVMTYGE-RPYWEL--SNHEVMKAI----ND----GFR----LPTPMDCP--SAIYQ-LMMQCWQQERARRPKFADIVSIL----
--IHIEKIIGSGDSGEVCYGRLR-------------VPGQRDVPVAIKALK-A-GYT-ERQRRDFLSEASIMGQF-DHPNIIRLEGVVT-RGRL------AMIVTEYMENGSLDTFLR--TH--------------------------------------------------------------------D-GQFTIMQLVGMLRGVGAGMRYLSDLG---YVHRDLAARNVLVDS---NL-VCKVSDFGLSRVL---ED--DPDA-------------AYTTTGGKIPIRWTAPEAIA-----FRT---FSSASDVWSFGVVMWEVLAYGE-RPYWNM--TNRDVISSV----EE----GYR----LPAPMGCP--HALHQ-LMLDCWHKDRAQRPRFSQIVSVL----
-V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREIYVAIKTLK-A-GYS-EKQRRDFLSEASIMGQF-DHPNIIRLEGVVT-KSRP------VMIITEFMENGALDSFLR--QN--------------------------------------------------------------------D-GQFTVIQLVGMLRGIAAGMKYLAEMN---YVHRDLAARNILVNS---NL-VCKVSDFGLSRYLQDDTS--DPTY--------------TSSLGGKIPVRWTAPEAIA-----YRK---FTSASDVWSYGIVMWEVMSFGE-RPYWDM--SNQDVINAI----EQ----DYR----LPPPMDCP--AALHQ-LMLDCWQKDRNSRPRFAEIVNTL----
-V-KIEQVIGAGEFGEVCSGHLK-------------LPGKREIFVAIKTLK-S-GYT-EKQRRDFLSEASIMGQF-DHPNVIHLEGVVT-KSTP------VMIITEFMENGSLDSFLR--QN--------------------------------------------------------------------D-GQFTVIQLVGMLRGIAAGMKYLADMN---YVHRDLAARNILVNS---NL-VCKVSDFGLSRFLEDDTS--DPTY--------------TSALGGKIPIRWTAPEAIQ-----YRK---FTSASDVWSYGIVMWEVMSYGE-RPYWDM--TNQDVINAI----EQ----DYR----LPPPMDCP--SALHQ-LMLDCWQKDRNHRPKFGQIVNTL----
-L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKMLK-S-DAT-EKDLSDLISEMEMMKMIGKHKNIINLLGACT-QDGP------LYVIVEYASKGNLREYLQ--ARRPPGLEY-----------------------------------------------------CYNPSHNPE-EQLSSKDLVSCAYQVARGMEYLASKK---CIHRDLAARNVLVTE---DN-VMKIADFGLARDI---HH--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRI---YTHQSDVWSFGVLLWEIFTLGG-SPYPGV--PVEELFKLL----KE----GHR----MDKPSNCT--NELYM-MMRDCWHAVPSQRPTFKQLVEDL----
--LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAVKMLK-D-DAT-EKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGP------LYVIVEYASKGNLREYLR--ARRPPGMEY-----------------------------------------------------SYDINRVPE-EQMTFKDLVSCTYQLARGMEYLASQK---CIHRDLAARNVLVTE---NN-VMKIADFGLARDI---NN--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRV---YTHQSDVWSFGVLMWEIFTLGG-SPYPGI--PVEELFKLL----KE----GHR----MDKPANCT--NELYM-MMRDCWHAVPSQRPTFKQLVEDL----
--LHLGRVLGYGAFGKVVEASAFG-----------IHKGSSCDTVAVKMLK-E-GAT-ASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGP------LMVIVEFCKYGNLSNFLR--AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----PGSSDRVLFARFSKTEGGARRASPDQEAEDLWL-SPLTMEDLVCYSFQVARGMEFLASRK---CIHRDLAARNILLSE---SD-VVKICDFGLARDI---YK--DPDY--------------VRKGSARLPLKWMAPESIF-----DKV---YTTQSDVWSFGVLLWEIFSLGA-SPYPGV-QINEEFCQRL----RD----GTR----MRAPELAT--PAIRR-IMLNCWSGDPKARPAFSELVEIL----
--ITMSRELGQGSFGMVYEGVAKG-----------VVKDEPETRVAIKTVN-E-AAS-MRERIEFLNEASVMKEF-NCHHVVRLLGVVS-QGQP------TLVIMELMTRGDLKSYLR--SLRPEM-----------------------------------------------------------ENNPVL-APPSLSKMIQMAGEIADGMAYLNANK---FVHRDLAARNCMVAE---DF-TVKIGDFGMTRDI---YE--TDYY--------------RKGGKGLLPVRWMSPESLK-----DGV---FTTYSDVWSFGVVLWEIATLAE-QPYQGL--SNEQVLRFV----ME----GGL----LDKPDNCP--DMLFE-LMRMCWQYNPKMRPSFLEIISS--I--
--ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAVKTVN-E-SAS-LRERIEFLNEASVMKGF-TCHHVVRLLGVVS-KGQP------TLVVMELMAHGDLKSYLR--SLRPEA-----------------------------------------------------------ENNPGR-PPPTLQEMIQMAAEIADGMAYLNAKK---FVHRDLAARNCMVAH---DF-TVKIGDFGMTRDI---YE--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGV---FTTSSDMWSFGVVLWEITSLAE-QPYQGL--SNEQVLKFV----MD----GGY----LDQPDNCP--ERVTD-LMRMCWQFNPKMRPTFLEIVNLL----
--LTFVQEIGSGQFGLVHLGYWL-----------------NKDKVAIKTIR-E-GAM-SE--EDFIEEAEVMMKL-SHPKLVQLYGVCL-EQAP------ICLVFEFMEHGCLSDYLR--TQ--------------------------------------------------------------------R-GLFAAETLLGMCLDVCEGMAYLEEAC---VIHRDLAARNCLVGE---NQ-VIKVSDFGMTRFV----L--DDQY--------------TSSTGTKFPVKWASPEVFS-----FSR---YSSKSDVWSFGVLMWEVFSEGK-IPYENR--SNSEVVEDI----ST----GFR----LYKPRLAS--THVYQ-IMNHCWKERPEDRPAFSRLLRQL----
--LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAVKMLK-E-GAT-HSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGP------LMVIVEFCKFGNLSTYLR--SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYK-DFLTLEHLICYSFQVAKGMEFLASRK---CIHRDLAARNILLSE---KN-VVKICDFGLARDI---YK--DPDY--------------VRKGDARLPLKWMAPETIF-----DRV---YTIQSDVWSFGVLLWEIFSLGA-SPYPGV-KIDEEFCRRL----KE----GTR----MRAPDYTT--PEMYQ-TMLDCWHGEPSQRPTFSELVEHL----
-V-TLLRALGHGAFGEVYEGLVIG-----------LPGDSSPLQVAIKTLP-E-LCS-PQDELDFLMEALIISKF-RHQNIVRCVGLSL-RATP------RLILLELMSGGDMKSFLR--HSRP--------------------------------------------------------------HLGQP-SPLVMRDLLQLAQDIAQGCHYLEENH---FIHRDIAARNCLLSCAGPSR-VAKIGDFGMARDI---YR--ASYY--------------RRGDRALLPVKWMPPEAFL-----EGI---FTSKTDSWSFGVLLWEIFSLGY-MPYPGR--TNQEVLDFV----VG----GGR----MDPPRGCP--GPVYR-IMTQCWQHEPELRPSFASILERL----
--IEVEEVVGRGAFGVVCKAKWR------------------AKDVAIKQIE-----S-ESERKAFIVELRQLSRV-NHPNIVKLYGACL---NP------VCLVMEYAEGGSLYNVLH--GA-------------------------------------------------------------------EPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVA---GGTVLKICDFGTACDI----------Q--------------THMTNNKGSAAWMAPEVFE-----GSN---YSEKCDVFSWGIILWEVITR-R-KPFDEIGGPAFRIMWAV----HN----GTR----PPLIKNLP--KPIES-LMTRCWSKDPSQRPSMEEIVKI--M--
-L-ILGKILGEGEFGSVMEGNLK-------------QEDGTSLKVAVKTMKLD-NSS-QREIEEFLSEAACMKDF-SHPNVIRLLGVCI-EMSSQG-IPKPMVILPFMKYGDLHTYLL--YSRL---------------------------------------------------------------ETGP-KHIPLQTLLKFMVDIALGMEYLSNRN---FLHRDLAARNCMLRD---DM-TVCVADFGLSKKI---YS--GDYY--------------RQGRIAKMPVKWIAIESLA-----DRV---YTSKSDVWAFGVTMWEIATRGM-TPYPGV--QNHEMYDYL----LH----GHR----LKQPEDCL--DELYE-IMYSCWRTDPLDRPTFSVLRLQ--L--
--VHFNEVIGRGHFGCVYHGTLL-------------DNDGKKIHCAVKSLN-R-ITD-IGEVSQFLTEGIIMKDF-SHPNVLSLLGICLRSEGS------PLVVLPYMKHGDLRNFIR--NE--------------------------------------------------------------------T-HNPTVKDLIGFGLQVAKGMKYLASKK---FVHRDLAARNCMLDE---KF-TVKVADFGLARDM---YD--KEYYS------------VHNKTGAKLPVKWMALESLQ-----TQK---FTTKSDVWSFGVLLWELMTRGA-PPYPDV--NTFDITVYL----LQ----GRR----LLQPEYCP--DPLYE-VMLKCWHPKAEMRPSFSELVSR--I--
-I-EYVRDIGEGAFGRVFQARAPG-----------LLPYEPFTMVAVKMLK-E-EAS-ADMQADFQREAALMAEF-DNPNIVKLLGVCA-VGKP------MCLLFEYMAYGDLNEFLR--SMSPHTVCSLSHS---------------------------------------------DLSMRAQVSSPGP-PPLSCAEQLCIARQVAAGMAYLSERK---FVHRDLATRNCLVGE---NM-VVKIADFGLSRNI---YS--ADYY--------------KANENDAIPIRWMPPESIF-----YNR---YTTESDVWAYGVVLWEIFSYGL-QPYYGM--AHEEVIYYV----RD----GNI----LSCPENCP--VELYN-LMRLCWSKLPADRPSFTSIHRIL----
IV--LKWELGEGAFGKVFLAECHN-----------LLPEQDKMLVAVKALK-E-ASE-SA-RQDFQREAELLTML-QHQHIVRFFGVCT-EGRP------LLMVFEYMRHGDLNRFLR--SHGPDAKL------------------------------------------------------LAGGEDVAP-GPLGLGQLLAVASQVAAGMVYLAGLH---FVHRDLATRNCLVGQ---GL-VVKIGDFGMSRDI---YS--TDYY--------------RVGGRTMLPIRWMPPESIL-----YRK---FTTESDVWSFGVVLWEIFTYGK-QPWYQL--SNTEAIDCI----TQ----GRE----LERPRACP--PEVYA-IMRGCWQREPQQRHSIKDVHARL----
-I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKILVAVKTLK-D-ASD-NA-RKDFHREAELLTNL-QHEHIVKFYGVCV-EGDP------LIMVFEYMKHGDLNKFLR--AHGPDAV--------------------------------------------------------LMAEGNPP-TELTQSQMLHIAQQIAAGMVYLASQH---FVHRDLATRNCLVGE---NL-LVKIGDFGMSRDV---YS--TDYY--------------RVGGHTMLPIRWMPPESIM-----YRK---FTTESDVWSLGVVLWEIFTYGK-QPWYQL--SNNEVIECI----TQ----GRV----LQRPRTCP--QEVYE-LMLGCWQREPHMRKNIKGIHTL--L--
-I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKMLVAVKALK-D-PTL-AA-RKDFQREAELLTNL-QHEHIVKFYGVCG-DGDP------LIMVFEYMKHGDLNKFLR--AHGPDAMIL-----------------------------------------------------VDGQPRQAK-GELGLSQMLHIASQIASGMVYLASQH---FVHRDLATRNCLVGA---NL-LVKIGDFGMSRDV---YS--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----YRK---FTTESDVWSFGVILWEIFTYGK-QPWFQL--SNTEVIECI----TQ----GRV----LERPRVCP--KEVYD-VMLGCWQREPQQRLNIKEIYKIL----
--IELGRCIGEGQFGDVHQGIYM-------------SPENPALAVAIKTCK-N-CTS-DSVREKFLQEALTMRQF-DHPHIVKLIGVIT--ENP------VWIIMELCTLGELRSFLQ--VR--------------------------------------------------------------------K-YSLDLASLILYAYQLSTALAYLESKR---FVHRDIAARNVLVSS---ND-CVKLGDFGLSRYM----E--DSTY--------------YKASKGKLPIKWMAPESIN-----FRR---FTSASDVWMFGVCMWEILMHGV-KPFQGV--KNNDVIGRI----EN----GER----LPMPPNCP--PTLYS-LMTKCWAYDPSRRPRFTELKAQL----
-L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYTTVAVKMLK-E-NAS-PSELRDLLSEFNVLKQV-NHPHVIKLYGACS-QDGP------LLLIVEYAKYGSLRGFLR--ESRKVGPGYLGSG---------------------------------------------GSRNSSSLDHPDE-RALTMGDLISFAWQISQGMQYLAEMK---LVHRDLAARNILVAE---GR-KMKISDFGLSRDV---YE--EDSY--------------VKRSQGRIPVKWMAIESLF-----DHI---YTTQSDVWSFGVLLWEIVTLGG-NPYPGI--PPERLFNLL----KT----GHR----MERPDNCS--EEMYR-LMLQCWKQEPDKRPVFADISKDL----
--WEIIGELGDGAFGKVYKAQNK----------------ETSVLAAAKVIDTK-SEEELE--DYM-VEIDILASC-DHPNIVKLLDAFY-YENN------LWILIEFCAGGAVDAVMLELER-----------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHDNK---IIHRDLKAGNILFTL---DG-DIKLADFGVSAKN----TRTIQRR--------------DS---FIGTPYWMAPEVVMCETSKDRP---YDYKADVWSLGITLIEMAE-IE-PPHHEL--NPMRVLLKI----AK----SEP----PTLAQPSRWSSNFKD-FLKKCLEKNVDARWTTSQLLQHPFV--
-L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAIKTLK-P-GTM-SP--EAFLQEAQVMKKL-RHEKLVQLYAVVS--EEP------IYIVTEYMSKGSLLDFLK--GE-------------------------------------------------------------------TG-KYLRLPQLVDMAAQIASGMAYVERMN---YVHRDLRAANILVGE---NL-VCKVADFGLARLI----E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILLTELTTKGR-VPYPGM--VNREVLDQV----ER----GYR----MPCPPECP--ESLHD-LMCQCWRKEPEERPTFEYLQAF--L--
-L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAIKTLK-P-GTM-MP--EAFLQEAQIMKKL-RHDKLVPLYAVVS--EEP------IYIVTEFMSKGSLLDFLK--EG-------------------------------------------------------------------DG-KYLKLPQLVDMAAQIADGMAYIERMN---YIHRDLRAANILVGE---NL-VCKIADFGLARLI----E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILQTELVTKGR-VPYPGM--VNREVLEQV----ER----GYR----MPCPQGCP--ESLHE-LMNLCWKKDPDERPTFEYIQSFL----
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