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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK DDR1 203
TK ABL1 261
TK ABL2 288
TKL BRAF 456
TK FGFR1 478
TK FLT1 827
TK FLT4 845
TK INSR 1023
TK ITK 363
TK KDR 834
TK KIT 589
TK LCK 245
TK PDGFRA 593
TK PDGFRB 600
TK TEK 824
-LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRP-DATKNARNDFLKEVKIMSRL-KDPNIIRLLGVCV-QDDPLCMITDYMENGDLNQFLSAHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGK---FTTASDVWAFGVTLWEVLMLCRAQPFGQL-TDEQVIENAGEFFRDQGRQ-VYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL--
-ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTLKE-DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-REPPFYIITEFMTYGNLLDYLREC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNK---FSIKSDVWAFGVLLWEIATYGM-SPYPGI-DLSQVYELL----EKDYR----MERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F-
-ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTLKE-DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-LEPPFYIVTEYMPYGNLLDYLREC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNT---FSIKSDVWAFGVLLWEIATYGM-SPYPGI-DLSQVYDLL----EKGYR----MEQPEGCPPKVYELMRACWKWSPADRPSFAETHQA-F-
-ITVGQRIGSGSFGTVYKGKWH-------------------GDVAVKMLNVTAPTPQQLQAFKNEVGVLRKT-RHVNILLFMGYST--KPQLAIVTQWCEGSSLYHHLHII--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQ-LPYSNINNRDQIIFMV----GRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA--SI
L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKMLKS-DATEKDLSDLISEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNLREYLQARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRI---YTHQSDVWSFGVLLWEIFTLGG-SPYPGV-PVEELFKLL----KEGHR----MDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL--
-LKLGKSLGRGAFGKVVQASAFG-----------IKKSPTCRTVAVKMLKE-GATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPR--------------------------------LDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKI---YSTKSDVWSYGVLLWEIFSLGG-SPYPGVQMDEDFCSRL----REGMR----MRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL--
-LHLGRVLGYGAFGKVVEASAFG-----------IHKGSSCDTVAVKMLKE-GATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKV---YTTQSDVWSFGVLLWEIFSLGA-SPYPGVQINEEFCQRL----RDGTR----MRAPELATPAIRRIMLNCWSGDPKARPAFSELVEIL--
-ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAVKTVNE-SASLRERIEFLNEASVMKGF-TCHHVVRLLGVVS-KGQPTLVVMELMAHGDLKSYLRSLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGV---FTTSSDMWSFGVVLWEITSLAE-QPYQGL-SNEQVLKFV----MDGGY----LDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL--
-LTFVQEIGSGQFGLVHLGYWL-----------------NKDKVAIKTIRE-GAMSE--EDFIEEAEVMMKL-SHPKLVQLYGVCL-EQAPICLVFEFMEHGCLSDYLRTQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFV-LDDQYTSSTGTKFPVKWASPEVFSFSR---YSSKSDVWSFGVLMWEVFSEGK-IPYENR-SNSEVVEDI----STGFR----LYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQL--
-LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAVKMLKE-GATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRV---YTIQSDVWSFGVLLWEIFSLGA-SPYPGVKIDEEFCRRL----KEGTR----MRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL--
-LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAVKMLKP-SAHLTEREALMSELKVLSYLGNHMNIVNLLGACT-IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCV---YTFESDVWSYGIFLWELFSLGS-SPYPGMPVDSKFYKMI----KEGFR----MLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQL-I-
-LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSLKQ-GSMSP--DAFLAEANLMKQL-QHQRLVRLYAVVT--QEPIYIITEYMENGSLVDFLKTP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI-EDNEYTAREGAKFPIKWTAPEAINYGT---FTIKSDVWSFGILLTEIVTHGR-IPYPGM-TNPEVIQNL----ERGYR----MVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L-
L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAVKMLKP-TARSSEKQALMSELKIMTHLGPHLNIVNLLGACT-KSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNL---YTTLSDVWSYGILLWEIFSLGG-TPYPGMMVDSTFYNKI----KSGYR----MAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE--IV
L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAVKMLKS-TARSSEKQALMSELKIMSHLGPHLNVVNLLGACT-KGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSL---YTTLSDVWSFGILLWEIFTLGG-TPYPELPMNEQFYNAI----KRGYR----MAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVL--LL
-IKFQDVIGEGNFGQVLKARIK--------------KDGLRMDAAIKRMKE-YASKDDHRDFAGELEVLCKLGHHPNIINLLGACE-HRGYLYLAIEYAPHGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVYVKKTMGRLPVRWMAIESLNYSV---YTTNSDVWSYGVLLWEIVSLGG-TPYCGM-TCAELYEKL----PQGYR----LEKPLNCDDEVYDLMRQCWREKPYERPSFAQILV--SL
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