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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK DDR1 203
TK ABL1 261
TK ALK 1116
TK AXL 527
TK BLK 241
TK BMX 422
TK BTK 402
TK DDR2 563
TK EGFR 712
TK EPHA1 624
TK EPHA3 621
TK EPHA4 621
TK EPHA5 675
TK EPHA6 631
TK EPHB1 619
TK EPHB2 621
TK EPHB4 615
TK EPHB6 670
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FLT4 845
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK INSRR 979
TK ITK 363
TK JAK2 849
TK KDR 834
TK LCK 245
TK MERTK 587
TK MUSK 575
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
TK PTK2 422
TK PTK2B 425
TK RET 724
TKL RIPK1 17
TK ROS1 1945
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
STE SLK 34
TK SRC 270
STE STK24 24
TK TEC 370
TK TEK 824
TK TXK 271
TK TYK2 589
TK YES1 277
-------LRFKEKLGEGQFGEV---HLCEVDSPQDLVSLDFPLNVRKGHPL---LVAVKIL-R-P-DAT-KNARNDFL-KEVKIMSRL-KDPNIIRLLGVCV--QDDP------LCMITDYMENGDLNQFLS--AHQLEDKAAE-----------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGE-----NFTIKIADFGMSRNL-------YA--GDYY--------------RVQGRAVLPIRWMAWECIL-----MGK--FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL-TDEQVIENAGEFFRD----QGRQVYLS---RPPACP--QGLYE-LMLRCWSRESEQRPP-----FSQLHRFL----
-------ITMKHKLGGGQYGEV---YEGVWK----------------KYSL---TVAVKTL-K-E-DTM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCT--REPP------FYIITEFMTYGNLLDYLR--EC----------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE-----NHLVKVADFGLSRLM--------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNK--FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQVYELL----EK----DYR---ME---RPEGCP--EKVYE-LMRACWQWNPSDRPS-----FAEIHQA--F--
------I-TLIRGLGHGAFGEV---YEGQVSG-----------MPNDPSPL---QVAVKTL-P-E-VCS-EQDELDFL-MEALIISKF-NHQNIVRCIGVSL--QSLP------RFILLELMAGGDLKSFLR--ETRP-----------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCP--GPGRVAKIGDFGMARDI-------YR--ASYY--------------RKGGCAMLPVKWMPPEAFM-----EGI--FTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK-SNQEVLEFV----TS----GGR---MD---PPKNCP--GPVYR-IMTQCWQHQPEDRPN-----FAIILER--I--
------V-ALGKTLGEGEFGAV---MEGQLN--------------QDDSIL---KVAVKTM-K-IAICT-RSELEDFL-SEAVCMKEF-DHPNVMRLIGVCF--QGSERESFPAPVVILPFMKHGDLHSFLL--YSRL------------------------------------------------------------GDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNE-----NMSVCVADFGLSKKI-------YN--GDYY--------------RQGRIAKMPVKWIAIESLA-----DRV--YTSKSDVWSFGVTMWEIATRGQ-TP---------------YPGV-ENSEIYDYL----RQ----GNR---LK---QPADCL--DGLYA-LMSRCWELNPQDRPS-----FTELREDL----
------L-RLVRKLGSGQFGEV---WMGYYK-----------------NNM---KVAIKTL-K-E-GTM-SP--EAFL-GEANVMKAL-QHERLVRLYAVVT---KEP------IYIVTEYMARGCLLDFLK--TD----------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSE-----ALCCKIADFGLARII-----------DSEY--------------TAQEGAKFPIKWTAPEAIH-----FGV--FTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM-SNPEVIRNL----ER----GYR---MP---RPDTCP--PELYRGVIAECWRSRPEERPT-----FEFLQSV--L--
-------ITLLKELGSGQFGVV---QLGKWK-----------------GQY---DVAVKMI-K-E-GSM-SE--DEFF-QEAQTMMKL-SHPKLVKFYGVCS--KEYP------IYIVTEYISNGCLLNYLR--SH-----------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDR-----DLCVKVSDFGMTRYV--------L--DDQY--------------VSSVGTKFPVKWSAPEVFH-----YFK--YSSKSDVWAFGILMWEVFSLGK-QP---------------YDLY-DNSQVVLKV----SQ----GHR---LY---RPHLAS--DTIYQ-IMYSCWHELPEKRPT-----FQQLLSS--I--
-------LTFLKELGTGQFGVV---KYGKWR-----------------GQY---DVAIKMI-K-E-GSM-SE--DEFI-EEAKVMMNL-SHEKLVQLYGVCT--KQRP------IFIITEYMANGCLLNYLR--EM-----------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVND-----QGVVKVSDFGLSRYV--------L--DDEY--------------TSSVGSKFPVRWSPPEVLM-----YSK--FSSKSDIWAFGVLMWEIYSLGK-MP---------------YERF-TNSETAEHI----AQ----GLR---LY---RPHLAS--EKVYT-IMYSCWHEKADERPT-----FKILLSN--I--
-------LTFKEKLGEGQFGEV---HLCEVEGMEKFKDKDFALDVSANQPV---LVAVKML-R-A-DAN-KNARNDFL-KEIKIMSRL-KDPNIIHLLAVCI--TDDP------LCMITEYMENGDLNQFLS--RHEPPN--------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK-----NYTIKIADFGMSRNL-------YS--GDYY--------------RIQGRAVLPIRWMSWESIL-----LGK--FTTASDVWAFGVTLWETFTFCQEQP---------------YSQL-SDEQVIENT----GEFFRDQGRQTYLP---QPAICP--DSVYK-LMLSCWRRDTKNRPS-----FQEIHL---LL-
------F-KKIKVLGSGAFGTV---YKGLWIP------------EGEKVKI---PVAIKEL-R-E-ATS-PKANKEIL-DEAYVMASV-DNPHVCRLLGICL---TST------VQLITQLMPFGCLLDYVR--EH-----------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT-----PQHVKITDFGLAKLL-------GA--EEKE--------------YHAEGGKVPIKWMALESIL-----HRI--YTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI-PASEISSIL----EK----GER---LP---QPPICT--IDVYM-IMVKCWMIDADSRPK-----FRELI----IEF
-----LM--VDTVIGEGEFGEV---YRGTLR-------------LPSQDCK---TVAIKTL-K-D-TSP-GGQWWNFL-REATIMGQF-SHPHILHLEGVVT--KRKP------IMIITEFMENGALDAFLR--ER-----------------------------------------------------------------EDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQ-----NLCCKVSDFGLTRLL-------DD--FDGT--------------YETQGGKIPIRWTAPEAIA-----HRI--FTTASDVWSFGIVMWEVLSFGD-KP---------------YGEM-SNQEVMKSI----ED----GYR---LP---PPVDCP--APLYE-LMKNCWAYDRARRPH-----FQKLQAHL----
------I-SIDKVVGAGEFGEV---CSGRLK-------------LPSKKEI---SVAIKTL-K-V-GYT-EKQRRDFL-GEASIMGQF-DHPNIIRLEGVVT--KSKP------VMIVTEYMENGSLDSFLR--KH-----------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINS-----NLVCKVSDFGLSRVL-------ED--DPEA-------------AYTTRGGKIPIRWTSPEAIA-----YRK--FTSASDVWSYGIVLWEVMSYGE-RP---------------YWEM-SNQDVIKAV----DE----GYR---LP---PPMDCP--AALYQ-LMLDCWQKDRNNRPK-----FEQIVSIL----
-------IKIEKVIGVGEFGEV---CSGRLK-------------VPGKREI---CVAIKTL-K-A-GYT-DKQRRDFL-SEASIMGQF-DHPNIIHLEGVVT--KCKP------VMIITEYMENGSLDAFLR--KN-----------------------------------------------------------------DGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNS-----NLVCKVSDFGMSRVL-------ED--DPEA-------------AYTTRGGKIPIRWTAPEAIA-----YRK--FTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM-SNQDVIKAI----EE----GYR---LP---PPMDCP--IALHQ-LMLDCWQKERSDRPK-----FGQIVNML----
-------ITIERVIGAGEFGEV---CSGRLK-------------LPGKREL---PVAIKTL-K-V-GYT-EKQRRDFL-GEASIMGQF-DHPNIIHLEGVVT--KSKP------VMIVTEYMENGSLDTFLK--KN-----------------------------------------------------------------DGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINS-----NLVCKVSDFGLSRVL-------ED--DPEA-------------AYTTRGGKIPIRWTAPEAIA-----FRK--FTSASDVWSYGIVMWEVVSYGE-RP---------------YWEM-TNQDVIKAV----EE----GYR---LP---SPMDCP--AALYQ-LMLDCWQKERNSRPK-----FDEIVNML----
LPPRIPA--------------------------------------------------------------------------------------------------GRP------VMIVVEYMENGSLDSFLR--KH-----------------------------------------------------------------DGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNS-----NLVCKVSDFGLSRVL-------ED--DPEA-------------AYTTTGGKIPIRWTAPEAIA-----YRK--FSSASDAWSYGIVMWEVMSYGE-RP---------------YWEM-SNQDVILSI----EE----GYR---LP---APMGCP--ASLHQ-LMLHCWQKERNHRPK-----FTDIVSFL----
------V-KIEEVIGAGEFGEV---YKGRLK-------------LPGKREI---YVAIKTL-K-A-GYS-EKQRRDFL-SEASIMGQF-DHPNIIRLEGVVT--KSRP------VMIITEFMENGALDSFLR--QN-----------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNS-----NLVCKVSDFGLSRYLQ----DDTS--DPTY--------------TSSLGGKIPVRWTAPEAIA-----YRK--FTSASDVWSYGIVMWEVMSFGE-RP---------------YWDM-SNQDVINAI----EQ----DYR---LP---PPMDCP--AALHQ-LMLDCWQKDRNSRPR-----FAEIVNTL----
------V-KIEQVIGAGEFGEV---CSGHLK-------------LPGKREI---FVAIKTL-K-S-GYT-EKQRRDFL-SEASIMGQF-DHPNVIHLEGVVT--KSTP------VMIITEFMENGSLDSFLR--QN-----------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNS-----NLVCKVSDFGLSRFLE----DDTS--DPTY--------------TSALGGKIPIRWTAPEAIQ-----YRK--FTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM-TNQDVINAI----EQ----DYR---LP---PPMDCP--SALHQ-LMLDCWQKDRNHRPK-----FGQIVNTL----
------V-KIEEVIGAGEFGEV---CRGRLK-------------APGKKES---CVAIKTL-K-G-GYT-ERQRREFL-SEASIMGQF-EHPNIIRLEGVVT--NSMP------VMILTEFMENGALDSFLR--LN-----------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNS-----NLVCKVSDFGLSRFLE----ENSS--DPTY--------------TSSLGGKIPIRWTAPEAIA-----FRK--FTSASDAWSYGIVMWEVMSFGE-RP---------------YWDM-SNQDVINAI----EQ----DYR---LP---PPPDCP--TSLHQ-LMLDCWQKDRNARPR-----FPQVVSAL----
-------IKIEEVIGTGSFGEV---RQGRLQ-------------PRGRREQ---TVAIQAL-W-A-GGA-ESLQMTFL-GRAAVLGQF-QHPNILRLEGVVT--KSRP------LMVLTEFMELGPLDSFLR--QR-----------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNS-----HLVCKVARLGHSPQG----------------------------------PSCLLRWAAPEVIA-----HGK--HTTSSDVWSFGILMWEVMSYGE-RP---------------YWDM-SEQEVLNAI----EQ----EFR---LP---PPPGCP--PGLHL-LMLDTWQKDRARRPH-----FDQLVA---AF-
-----VI--LGELLGKGNFGEV---YKGTLK-----------------DKT---SVAVKTC-K-E-DLP-QELKIKFL-QEAKILKQY-DHPNIVKLIGVCT--QRQP------VYIIMELVSGGDFLTFLR--RK-----------------------------------------------------------------KDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGE-----NNVLKISDFGMSRQE--------D--GGVY--------------SSSGLKQIPIKWTAPEALN-----YGR--YSSESDVWSFGILLWETFSLGV-CP---------------YPGM-TNQQAREQV----ER----GYR---MS---APQHCP--EDISK-IMMKCWDYKPENRPK-----FSELQKEL----
------L-VLGEQIGRGNFGEV---FSGRLR----------------ADNT---LVAVKSC-R-E-TLP-PDLKAKFL-QEARILKQY-SHPNIVRLIGVCT--QKQP------IYIVMELVQGGDFLTFLR--TE-----------------------------------------------------------------GARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTE-----KNVLKISDFGMSREE-------AD--GVYA--------------ASGGLRQVPVKWTAPEALN-----YGR--YSSESDVWSFGILLWETFSLGA-SP---------------YPNL-SNQQTREFV----EK----GGR---LP---CPELCP--DAVFR-LMEQCWAYEPGQRPS-----FSTIYQEL----
------L-VLGKPLGEGCFGQV---VLAEAIGL---------DKDKPNRVT---KVAVKML-K-S-DAT-EKDLSDLI-SEMEMMKMIGKHKNIINLLGACT--QDGP------LYVIVEYASKGNLREYLQ--ARRPPGLEY--------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE-----DNVMKIADFGLARDI-------HH--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRI--YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV-PVEELFKLL----KE----GHR---MD---KPSNCT--NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL----
-------LTLGKPLGEGCFGQV---VMAEAVGI---------DKDKPKEAV---TVAVKML-K-D-DAT-EKDLSDLV-SEMEMMKMIGKHKNIINLLGACT--QDGP------LYVIVEYASKGNLREYLR--ARRPPGMEY--------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE-----NNVMKIADFGLARDI-------NN--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRV--YTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI-PVEELFKLL----KE----GHR---MD---KPANCT--NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL----
-------LTLGKPLGEGCFGQV---VMAEAIGI---------DKDRAAKPV---TVAVKML-K-D-DAT-DKDLSDLV-SEMEMMKMIGKHKNIINLLGACT--QGGP------LYVLVEYAAKGNLREFLR--ARRPPGLDY--------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE-----DNVMKIADFGLARDV-------HN--LDYY--------------KKTTNGRLPVKWMAPEALF-----DRV--YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI-PVEELFKLL----KE----GHR---MD---KPANCT--HDLYM-IMRECWHAAPSQRPT-----FKQLVEDL----
-------LHLGRVLGYGAFGKV---VEASAFG-----------IHKGSSCD---TVAVKML-K-E-GAT-ASEHRALM-SELKILIHIGNHLNVVNLLGACT-KPQGP------LMVIVEFCKYGNLSNFLR--AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR--PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSE-----SDVVKICDFGLARDI-------YK--DPDY--------------VRKGSARLPLKWMAPESIF-----DKV--YTTQSDVWSFGVLLWEIFSLGA-SP---------------YPGVQINEEFCQRL----RD----GTR---MR---APELAT--PAIRR-IMLNCWSGDPKARPA-----FSELVEIL----
-------LKLEKKLGAGQFGEV---WMATYN-----------------KHT---KVAVKTM-K-P-GSM-SV--EAFL-AEANVMKTL-QHDKLVKLHAVVT---KEP------IYIITEFMAKGSLLDFLK--SD----------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA-----SLVCKIADFGLARVI--------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----FGS--FTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM-SNPEVIRAL----ER----GYR---MP---RPENCP--EELYN-IMMRCWKNRPEERPT-----FEYIQSV--L--
-------ITMSRELGQGSFGMV---YEGVAKG-----------VVKDEPET---RVAIKTV-N-E-AAS-MRERIEFL-NEASVMKEF-NCHHVVRLLGVVS--QGQP------TLVIMELMTRGDLKSYLR--SLRPEM--------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE-----DFTVKIGDFGMTRDI-------YE--TDYY--------------RKGGKGLLPVRWMSPESLK-----DGV--FTTYSDVWSFGVVLWEIATLAE-QP---------------YQGL-SNEQVLRFV----ME----GGL---LD---KPDNCP--DMLFE-LMRMCWQYNPKMRPS-----FLEIISS--I--
-------ITLLRELGQGSFGMV---YEGNARD-----------IIKGEAET---RVAVKTV-N-E-SAS-LRERIEFL-NEASVMKGF-TCHHVVRLLGVVS--KGQP------TLVVMELMAHGDLKSYLR--SLRPEA--------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH-----DFTVKIGDFGMTRDI-------YE--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGV--FTTSSDMWSFGVVLWEITSLAE-QP---------------YQGL-SNEQVLKFV----MD----GGY---LD---QPDNCP--ERVTD-LMRMCWQFNPKMRPT-----FLEIVNLL----
------I-SIIRELGQGSFGMV---YEGLARG-----------LEAGEEST---PVALKTV-N-E-LAS-PRECIEFL-KEASVMKAF-KCHHVVRLLGVVS--QGQP------TLVIMELMTRGDLKSHLR--SLRPEA--------------------------------------------------------ENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQ-----DFTVKIGDFGMTRDV-------YE--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGI--FTTHSDVWSFGVVLWEIVTLAE-QP---------------YQGL-SNEQVLKFV----MD----GGV---LE---ELEGCP--LQLQE-LMSRCWQPNPRLRPS-----FTHILD---SI-
-------LTFVQEIGSGQFGLV---HLGYWL-----------------NKD---KVAIKTI-R-E-GAM-SE--EDFI-EEAEVMMKL-SHPKLVQLYGVCL--EQAP------ICLVFEFMEHGCLSDYLR--TQ-----------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGE-----NQVIKVSDFGMTRFV--------L--DDQY--------------TSSTGTKFPVKWASPEVFS-----FSR--YSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR-SNSEVVEDI----ST----GFR---LY---KPRLAS--THVYQ-IMNHCWKERPEDRPA-----FSRLLRQL----
-------LKFLQQLGKGNFGSV---EMCRYDP------------LQDNTGE---VVAVKKL-Q-H-STE--EHLRDFE-REIEILKSL-QHDNIVKYKGVCYSAGRRN------LKLIMEYLPYGSLRDYLQ--KH-----------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN-----ENRVKIGDFGLTKVL------PQD--KEYY--------------KVKEPGESPIFWYAPESLT-----ESK--FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM-IVFHLIELL----KN----NGR---LP---RPDGCP--DEIYM-IMTECWNNNVNQRPS-----FRDLA----LRV
-------LKLGKPLGRGAFGQV---IEADAFG-----------IDKTATCR---TVAVKML-K-E-GAT-HSEHRALM-SELKILIHIGHHLNVVNLLGACT-KPGGP------LMVIVEFCKFGNLSTYLR--SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE-----KNVVKICDFGLARDI-------YK--DPDY--------------VRKGDARLPLKWMAPETIF-----DRV--YTIQSDVWSFGVLLWEIFSLGA-SP---------------YPGVKIDEEFCRRL----KE----GTR---MR---APDYTT--PEMYQ-TMLDCWHGEPSQRPT-----FSELVEHL----
-------LKLVERLGAGQFGEV---WMGYYN-----------------GHT---KVAVKSL-K-Q-GSM-SP--DAFL-AEANLMKQL-QHQRLVRLYAVVT---QEP------IYIITEYMENGSLVDFLK--TP----------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD-----TLSCKIADFGLARLI--------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----YGT--FTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM-TNPEVIQNL----ER----GYR---MV---RPDNCP--EELYQ-LMRLCWKERPEDRPT-----FDYLRSV--L--
------L-ILGKILGEGEFGSV---MEGNLK-------------QEDGTSL---KVAVKTM-KLD-NSS-QREIEEFL-SEAACMKDF-SHPNVIRLLGVCI--EMSSQG-IPKPMVILPFMKYGDLHTYLL--YSRL------------------------------------------------------------ETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRD-----DMTVCVADFGLSKKI-------YS--GDYY--------------RQGRIAKMPVKWIAIESLA-----DRV--YTSKSDVWAFGVTMWEIATRGM-TP---------------YPGV-QNHEMYDYL----LH----GHR---LK---QPEDCL--DELYE-IMYSCWRTDPLDRPT-----FSVLRLQ--L--
------I-EYVRDIGEGAFGRV---FQARAPG-----------LLPYEPFT---MVAVKML-K-E-EAS-ADMQADFQ-REAALMAEF-DNPNIVKLLGVCA--VGKP------MCLLFEYMAYGDLNEFLR--SMSPHTVCSLSHS------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGE-----NMVVKIADFGLSRNI-------YS--ADYY--------------KANENDAIPIRWMPPESIF-----YNR--YTTESDVWAYGVVLWEIFSYGL-QP---------------YYGM-AHEEVIYYV----RD----GNI---LS---CPENCP--VELYN-LMRLCWSKLPADRPS-----FTSIHRIL----
-----IV--LKWELGEGAFGKV---FLAECHN-----------LLPEQDKM---LVAVKAL-K-E-ASE-SA-RQDFQ-REAELLTML-QHQHIVRFFGVCT--EGRP------LLMVFEYMRHGDLNRFLR--SHGPDAKL---------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ-----GLVVKIGDFGMSRDI-------YS--TDYY--------------RVGGRTMLPIRWMPPESIL-----YRK--FTTESDVWSFGVVLWEIFTYGK-QP---------------WYQL-SNTEAIDCI----TQ----GRE---LE---RPRACP--PEVYA-IMRGCWQREPQQRHS-----IKDVHARL----
------I-VLKRELGEGAFGKV---FLAECYN-----------LCPEQDKI---LVAVKTL-K-D-ASD-NA-RKDFH-REAELLTNL-QHEHIVKFYGVCV--EGDP------LIMVFEYMKHGDLNKFLR--AHGPDAV-----------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGE-----NLLVKIGDFGMSRDV-------YS--TDYY--------------RVGGHTMLPIRWMPPESIM-----YRK--FTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL-SNNEVIECI----TQ----GRV---LQ---RPRTCP--QEVYE-LMLGCWQREPHMRKN-----IKGIHTL--L--
------I-VLKRELGEGAFGKV---FLAECYN-----------LSPTKDKM---LVAVKAL-K-D-PTL-AA-RKDFQ-REAELLTNL-QHEHIVKFYGVCG--DGDP------LIMVFEYMKHGDLNKFLR--AHGPDAMIL--------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA-----NLLVKIGDFGMSRDV-------YS--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----YRK--FTTESDVWSFGVILWEIFTYGK-QP---------------WFQL-SNTEVIECI----TQ----GRV---LE---RPRVCP--KEVYD-VMLGCWQREPQQRLN-----IKEIYKIL----
-------IELGRCIGEGQFGDV---HQGIYM-------------SPENPAL---AVAIKTC-K-N-CTS-DSVREKFL-QEALTMRQF-DHPHIVKLIGVIT---ENP------VWIIMELCTLGELRSFLQ--VR-----------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSS-----NDCVKLGDFGLSRYM--------E--DSTY--------------YKASKGKLPIKWMAPESIN-----FRR--FTSASDVWMFGVCMWEILMHGV-KP---------------FQGV-KNNDVIGRI----EN----GER---LP---MPPNCP--PTLYS-LMTKCWAYDPSRRPR-----FTELKAQL----
------V-VLNRILGEGFFGEV---YEGVYT-------------NHKGEKI---NVAVKTC-K-K-DCT-LDNKEKFM-SEAVIMKNL-DHPHIVKLIGIIE---EEP------TWIIMELYPYGELGHYLE--RN-----------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVAS-----PECVKLGDFGLSRYI--------E--DEDY--------------YKASVTRLPIKWMSPESIN-----FRR--FTTASDVWMFAVCMWEILSFGK-QP---------------FFWL-ENKDVIGVL----EK----GDR---LP---KPDLCP--PVLYT-LMTRCWDYDPSDRPR-----FTELVCS--L--
------L-VLGKTLGEGEFGKV---VKATAFH-----------LKGRAGYT---TVAVKML-K-E-NAS-PSELRDLL-SEFNVLKQV-NHPHVIKLYGACS--QDGP------LLLIVEYAKYGSLRGFLR--ESRKVGPGYLGSG------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE-----GRKMKISDFGLSRDV-------YE--EDSY--------------VKRSQGRIPVKWMAIESLF-----DHI--YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI-PPERLFNLL----KT----GHR---ME---RPDNCS--EEMYR-LMLQCWKQEPDKRPV-----FADISKDL----
----LES----AELDSGGFGKV---SLCFHR-----------------TQG---LMIMKTVYK-G-PNC-IEHNEALL-EEAKMMNRL-RHSRVVKLLGVII--EEGK------YSLVMEYMEKGNLMHVLK--AE------------------------------------------------------------------MSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDN-----DFHIKIADLGLASFKMWSKLNNE----EHNELR--------EVDGTAKKNGGTLYYMAPEHLN-----DVNAKPTEKSDVYSFAVVLWAIFA-NK-EP---------------YENAICEQQLIMCI----KS----GNR---PDVDDITEYCP--REIIS-LMKLCWEANPEARPT-----FPGIEEK--F--
-----LT--LRLLLGSGAFGEV---YEGTAVDI----------LGVGSGEI---KVAVKTL-K-K-GST-DQEKIEFL-KEAHLMSKF-NHPNILKQLGVCL--LNEP------QYIILELMEGGDLLTYLR--KARM-----------------------------------------------------------ATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI-------YK--NDYY--------------RKRGEGLLPVRWMAPESLM-----DGI--FTTQSDVWSFGILIWEILTLGH-QP---------------YPAH-SNLDVLNYV----QT----GGR---LE---PPRNCP--DDLWN-LMTQCWAQEPDQRPT-----FHRIQDQL----
-------FELLKVLGQGSFGKVFLVRKVTRP----------------DSGH---LYAMKVL-KKA-TLKVRD--RVRTKMERDILADV-NHPFVVKLHYAFQ--TEGK------LYLILDFLRGGDLFTRLS-KEV-------------------------------------------------------------------MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDE-----EGHIKLTDFGLSKEA--------IDHEKKA--------------YS---FCGTVEYMAPEVVN-----RQG--HSHSADWWSYGVLMFEMLT-GS-LP---------------FQGK----DRKETM----TL----ILK---AK---LGMPQFLSTEAQS-LLRALFKRNPANRLGSGPDGAEEIKRHV--FY
-------FELLKVLGQGSYGKV---FLVRKV----------------KGSDAGQLYAMKVL-KKA-TLKVRD--RVRSKMERDILAEV-NHPFIVKLHYAFQ--TEGK------LYLILDFLRGGDLFTRLS-KEV-------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDE-----EGHIKITDFGLSKEA--------IDHDKRA--------------YS---FCGTIEYMAPEVVN-----RRG--HTQSADWWSFGVLMFEMLT-GS-LP---------------FQGK----DRKETM----AL----ILK---AK---LGMPQFLSGEAQS-LLRALFKRNPCNRLGAGIDGVEEIKRHPFF--
-------FELLKVLGQGSFGKV---FLVKKI----------------SGSDARQLYAMKVL-KKA-TLKVRD--RVRTKMERDILVEV-NHPFIVKLHYAFQ--TEGK------LYLILDFLRGGDLFTRLS-KEV-------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDE-----EGHIKLTDFGLSKES--------IDHEKKA--------------YS---FCGTVEYMAPEVVN-----RRG--HTQSADWWSFGVLMFEMLT-GT-LP---------------FQGK----DRKETM----TM----ILK---AK---LGMPQFLSPEAQS-LLRMLFKRNPANRLGAGPDGVEEIKRHSFF--
-------WEIIGELGDGAFGKV---YKAQNK----------------ETSV---LAAAKVI-DTK-SEEELE--DYM--VEIDILASC-DHPNIVKLLDAFY--YENN------LWILIEFCAGGAVDAVMLELER-------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTL-----DGDIKLADFGVSAKN--------TRTIQRR--------------DS---FIGTPYWMAPEVVMCETSKDRP--YDYKADVWSLGITLIEMAE-IE-PP---------------HHEL-NPMRVLLKI----AK----SEP---PT---LAQPSRWSSNFKD-FLKKCLEKNVDARWT-----TSQLLQHPFV--
------L-RLEVKLGQGCFGEV---WMGTWN-----------------GTT---RVAIKTL-K-P-GTM-SP--EAFL-QEAQVMKKL-RHEKLVQLYAVVS---EEP------IYIVTEYMSKGSLLDFLK--GE----------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE-----NLVCKVADFGLARLI--------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR--FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM-VNREVLDQV----ER----GYR---MP---CPPECP--ESLHD-LMCQCWRKEPEERPT-----FEYLQAF--L--
-------FTKLEKIGKGSFGEV---FKGIDN----------------RTQK---VVAIKII-DLE-EAEDEI--EDIQ-QEITVLSQC-DSPYVTKYYGSYL--KDTK------LWIIMEYLGGGSALDLLE--PG-------------------------------------------------------------------PLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSE-----HGEVKLADFGVAGQL--------TDTQIKR--------------NT---FVGTPFWMAPEVIK-----QSA--YDSKADIWSLGITAIELAR-GE-PP---------------HSEL-HPMKVLFLI----PK----NNP---PT---LEGNYS--KPLKE-FVEACLNKEPSFRPT-----AKELLKHKFI--
-------LTFMRELGSGLFGVV---RLGKWR-----------------AQY---KVAIKAI-R-E-GAM-CE--EDFI-EEAKVMMKL-THPKLVQLYGVCT--QQKP------IYIVTEFMERGCLLNFLR--QR-----------------------------------------------------------------QGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSE-----AGVVKVSDFGMARYV--------L--DDQY--------------TSSSGAKFPVKWCPPEVFN-----YSR--FSSKSDVWSFGVLMWEVFTEGR-MP---------------FEKY-TNYEVVTMV----TR----GHR---LY---QPKLAS--NYVYE-VMLRCWQEKPEGRPS-----FEDLLRT--I--
-------IKFQDVIGEGNFGQV---LKARIK--------------KDGLRM---DAAIKRM-K-E-YAS-KDDHRDFA-GELEVLCKLGHHPNIINLLGACE--HRGY------LYLAIEYAPHGNLLDFLR--KSRVLETDP--------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE-----NYVAKIADFGLSRGQ------------EVY--------------VKKTMGRLPVRWMAIESLN-----YSV--YTTNSDVWSYGVLLWEIVSLGG-TP---------------YCGM-TCAELYEKL----PQ----GYR---LE---KPLNCD--DEVYD-LMRQCWREKPYERPS-----FAQILV---SL-
------L-AFIKEIGSGQFGVV---HLGEWR-----------------SHI---QVAIKAI-N-E-GSM-SE--EDFI-EEAKVMMKL-SHSKLVQLYGVCI--QRKP------LYIVTEFMENGCLLNYLR--EN-----------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSS-----TCIVKISDFGMTRYV--------L--DDEY--------------VSSFGAKFPIKWSPPEVFL-----FNK--YSSKSDVWSFGVLMWEVFTEGK-MP---------------FENK-SNLQVVEAI----SE----GFR---LY---RPHLAP--MSIYE-VMYSCWHEKPEGRPT-----FAELLR---AV-
------L-KKIRDLGEGHFGKV---SLYCYDP------------TNDGTGE---MVAVKAL-K-A-DCG-PQHRSGWK-QEIDILRTL-YHEHIIKYKGCCEDQGEKS------LQLVMEYVPLGSLRDYLP--RH-------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDN-----DRLVKIGDFGLAKAV------PEG--HEYY--------------RVREDGDSPVFWYAPECLK-----EYK--FYYASDVWSFGVTLYELLTHCD-SSQSPPTKF-LELIGIAQGQM-TVLRLTELL----ER----GER---LP---RPDKCP--CEVYH-LMKNCWETEASFRPT-----FENLIP---IL-
------L-RLEVKLGQGCFGEV---WMGTWN-----------------GTT---KVAIKTL-K-P-GTM-MP--EAFL-QEAQIMKKL-RHDKLVPLYAVVS---EEP------IYIVTEFMSKGSLLDFLK--EG----------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGE-----NLVCKIADFGLARLI--------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR--FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM-VNREVLEQV----ER----GYR---MP---CPQGCP--ESLHE-LMNLCWKKDPDERPT-----FEYIQSFL----
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