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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK DDR1 203
TK ABL1 261
TK ALK 1116
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK BLK 241
TK BTK 402
CMGC CDC2 4
CMGC CDK15 103
CMGC CDK2 4
CMGC CDK4 6
CMGC CDK6 13
CMGC CDKL2 4
CAMK DAPK3 13
TK DDR2 563
Other DSTYK 651
TK EGFR 712
TK EPHA3 621
TK EPHB1 619
TK EPHB4 615
TK EPHB6 670
TK ERBB4 718
TK FER 563
TK FES 561
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK HCK 241
CMGC ICK 4
TK IGF1R 999
TK INSR 1023
TK INSRR 979
TKL IRAK4 186
TK ITK 363
TK JAK2 849
TK KIT 589
TK LCK 245
TK LTK 510
CMGC MAK 4
TK MATK 235
TK MET 1078
TK MUSK 575
Other NEK1 4
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
STE OXSR1 17
STE PAK1 270
STE PAK3 268
CMGC PCTK2 192
TK PDGFRA 593
TK PDGFRB 600
TK PTK2B 425
TK RET 724
TKL RIPK1 17
TK ROS1 1945
TK SRC 270
STE STK24 24
STE STK3 27
STE STK39 63
STE STK4 30
STE TAOK1 28
STE TAOK2 28
STE TAOK3 24
Other TLK2 440
TK TNK1 116
TK TNK2 150
TK YES1 277
----LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPL-LVAVKIL---R-P--D-AT----KNARN-DFL-K-----EVKIMSRL--K---DPNIIRLLGVCV--Q-------DDPLCMITDYMENGDLNQFLS---------AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATL--NFVHRDLATRNCLVGE-----NFTI----KIADFGMSRNL-------Y----A--GDYY--------------RVQGRAVLPIRWMAWECIL----MGK--FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL---TDEQVIENAGEFFRD----QGRQVYLS---RPPACP-------------------------------QGLYE-LMLRCWSRESEQRPPFSQLHRFL-----------
----ITMKHKLGGGQYGEVYEGVWK----------------KYSL-TVAVKTL---K-E--D-TM----EV--E-EFL-K-----EAAVMKEI--K---HPNLVQLLGVCT--R-------EPPFYIITEFMTYGNLLDYLR---------EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK--NFIHRDLAARNCLVGE-----NHLV----KVADFGLSRLM------------T--GDTY--------------TAHAGAKFPIKWTAPESLA----YNK--FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI---DLSQVYELL----EK----DYR---ME---RPEGCP-------------------------------EKVYE-LMRACWQWNPSDRPSFAEIHQA--F---------
---I-TLIRGLGHGAFGEVYEGQVSG-----------MPNDPSPL-QVAVKTL---P-E--V-CS----EQDEL-DFL-M-----EALIISKF--N---HQNIVRCIGVSL--Q-------SLPRFILLELMAGGDLKSFLR---------ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN--HFIHRDIAARNCLLTCP--GPGRVA----KIGDFGMARDI-------Y----R--ASYY--------------RKGGCAMLPVKWMPPEAFM----EGI--FTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK---SNQEVLEFV----TS----GGR---MD---PPKNCP-------------------------------GPVYR-IMTQCWQHQPEDRPNFAIILER--I---------
----FEIGRPLGKGKFGNVYLAREK----------------QSKF-ILALKVL---FKA--QLEKA---GV--E-HQLRR-----EVEIQSHL--R---HPNILRLYGYFH--D-------ATRVYLILEYAPLGTVYRELQ--------KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK--RVIHRDIKPENLLLGS-----AGEL----KIADFGWSV--------------HAPSSRR--------------TT---LCGTLDYLPPEMIE----GRM--HDEKVDLWSLGVLCYEFLV-GK-PP---------------FEAN------TYQETY----KR----ISR---VE---FTFPDFVT-----------------------------EGARD-LISRLLKHNPSQRPMLREVLEHPWI---------
----FEIGRPLGKGKFGNVYLAREK----------------KSHF-IVALKVL---FKS--Q-IEK---EG--V-EHQLR----REIEIQAHL--H---HPNILRLYNYFY--D-------RRRIYLILEYAPRGELYKELQ--------KSC----------------------------------------------------------------------------------------------------TFDEQRTATIMEELADALMYCHGK--KVIHRDIKPENLLLGL-----KGEL----KIADFGWSV--------------HAPSLRR--------------KT---MCGTLDYLPPEMIE----GRM--HNEKVDLWCIGVLCYELLV-GN-PP---------------FESA------SHNETY----RR----IVK---VD---LKFPASVP-----------------------------MGAQD-LISKLLRHNPSERLPLAQVSAHPWV---------
----FEIGRPLGKGKFGNVYLARLK----------------ESHF-IVALKVL---FKS--Q-IEK---EG--L-EHQLR----REIEIQAHL--Q---HPNILRLYNYFH--D-------ARRVYLILEYAPRGELYKELQ--------KSE----------------------------------------------------------------------------------------------------KLDEQRTATIIEELADALTYCHDK--KVIHRDIKPENLLLGF-----RGEV----KIADFGWSV--------------HTPSLRR--------------KT---MCGTLDYLPPEMIE----GRT--YDEKVDLWCIGVLCYELLV-GY-PP---------------FESA------SHSETY----RR----ILK---VD---VRFPLSMP-----------------------------LGARD-LISRLLRYQPLERLPLAQILKHPWV---------
---L-RLVRKLGSGQFGEVWMGYYK-----------------NNM-KVAIKTL---K-E--G-TM----SP--E-AFL-G-----EANVMKAL--Q---HERLVRLYAVVT----------KEPIYIVTEYMARGCLLDFLK---------TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERM--NSIHRDLRAANILVSE-----ALCC----KIADFGLARII---------------DSEY--------------TAQEGAKFPIKWTAPEAIH----FGV--FTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM---SNPEVIRNL----ER----GYR---MP---RPDTCP-------------------------------PELYRGVIAECWRSRPEERPTFEFLQSV--L---------
----LTFLKELGTGQFGVVKYGKWR-----------------GQY-DVAIKMI---K-E--G-SM----SE--D-EFI-E-----EAKVMMNL--S---HEKLVQLYGVCT--K-------QRPIFIITEYMANGCLLNYLR---------EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESK--QFLHRDLAARNCLVND-----QGVV----KVSDFGLSRYV------------L--DDEY--------------TSSVGSKFPVRWSPPEVLM----YSK--FSSKSDIWAFGVLMWEIYSLGK-MP---------------YERF---TNSETAEHI----AQ----GLR---LY---RPHLAS-------------------------------EKVYT-IMYSCWHEKADERPTFKILLSN--I---------
----YTKIEKIGEGTYGVVYKGRHK----------------TTGQ-VVAMKKI---RLE--S-EEE---GV--P-STAIR-----EISLLKEL--R---HPNIVSLQDVLM--Q-------DSRLYLIFEFLSM-DLKKYLDS-----IPPGQ----------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSR--RVLHRDLKPQNLLIDD-----KGTI----KLADFGLARAF------------GIPIRVY--------------TH---EVVTLWYRSPEVLL---GSAR--YSTPVDIWSIGTIFAELAT-KK-PL---------------FHGD---SEIDQLFRI----FR----ALG---TP---NNEVWPEVESLQDYKNTFPKWKP---GSLASHVKNLDENGLD-LLSKMLIYDPAKRISGKMALNHPYF---------
--YL--NLEKLGEGSYATVYKGISR----------------INGQ-LVALKVI---SMN--A-EEG---VP----FTAIR-----EASLLKGL--K---HANIVLLHDIIH--T-------KETLTFVFEYMHT-DLAQYMS-------QHPG----------------------------------------------------------------------------------------------------GLHPHNVRLFMFQLLRGLAYIHHQ--HVLHRDLKPQNLLISH-----LGEL----KLADFGLARAK------------SIPSQTY--------------SS---EVVTLWYRPPDALL---GATE--YSSELDIWGAGCIFIEMFQ-GQ-PL---------------FPGV--SNILEQLEKI----WE----VLG---VP---TEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAED-LASQMLKGFPRDRVSAQEALVHDYF---------
----FQKVEKIGEGTYGVVYKARNK----------------LTGE-VVALKKI---RLD--T-ETE---GV--P-STAIR-----EISLLKEL--N---HPNIVKLLDVIH--T-------ENKLYLVFEFLHQ-DLKKFMDA------SALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH--RVLHRDLKPQNLLINT-----EGAI----KLADFGLARAF------------GVPVRTY--------------TH---EVVTLWYRAPEILL---GCKY--YSTAVDIWSLGCIFAEMVT-RR-AL---------------FPGD---SEIDQLFRI----FR----TLG---TP---DEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRISAKAALAHPFF---------
---Y-EPVAEIGVGAYGTVYKARDP----------------HSGH-FVALKSV---RVP--N-GGGGGGGL--P-ISTVR-----EVALLRRL--EAFEHPNVVRLMDVCA--TSR--TDREIKVTLVFEHVDQ-DLRTYLDK------APPP----------------------------------------------------------------------------------------------------GLPAETIKDLMRQFLRGLDFLHAN--CIVHRDLKPENILVTS-----GGTV----KLADFGLARI-------------YSYQMAL--------------TP---VVVTLWYRAPEVLL----QST--YATPVDMWSVGCIFAEMFR-RK-PL---------------FCGN---SEADQLGKI----FD----LIG---LP---PEDDWPRDVSLPRGAFPPRGPR-----PVQSVVPEMEESGAQ-LLLEMLTFNPHKRISAFRALQHSYL---------
----YECVAEIGEGAYGKVFKARDL----------------KNGGRFVALKRV---RVQ--T-GEE---GM--P-LSTIR-----EVAVLRHL--ETFEHPNVVRLFDVCT--VSR--TDRETKLTLVFEHVDQ-DLTTYLDK------VPEP----------------------------------------------------------------------------------------------------GVPTETIKDMMFQLLRGLDFLHSH--RVVHRDLKPQNILVTS-----SGQI----KLADFGLARI-------------YSFQMAL--------------TS---VVVTLWYRAPEVLL----QSS--YATPVDLWSVGCIFAEMFR-RK-PL---------------FRGS---SDVDQLGKI----LD----VIG---LP---GEEDWPRDVALPRQAFHSKSAQ-----PIEKFVTDIDELGKD-LLLKCLTFNPAKRISAYSALSHPYF---------
----YENLGLVGEGSYGMVMKCRNK----------------DTGR-IVAIKKF---LES--D-DDK---MV--K-KIAMR-----EIKLLKQL--R---HENLVNLLEVCK--K-------KKRWYLVFEFVDHTILDDLEL--------FPN----------------------------------------------------------------------------------------------------GLDYQVVQKYLFQIINGIGFCHSH--NIIHRDIKPENILVSQ-----SGVV----KLCDFGFARTL------------AAPGEVY--------------TD---YVATRWYRAPELLV---GDVK--YGKAVDVWAIGCLVTEMFM-GE-PL---------------FPGD---SDIDQLYHI----MM----CLG---NL---IPRHQELFNKNPVFAGVRLPEIKE-REPLERRYPKLSEVVID-LAKKCLHIDPDKRPFCAELLHHDFF---------
----YEMGEELGSGQFAIVRKCRQK----------------GTGK-EYAAKFI---KKR--R-LSS---SR--R-GVSREEI-EREVNILREI--R---HPNIITLHDIFE--N-------KTDVVLILELVSGGELFDFLA--------EKE----------------------------------------------------------------------------------------------------SLTEDEATQFLKQILDGVHYLHSK--RIAHFDLKPENIMLLD-----KNVPNPRIKLIDFGIAHK-------------IEAGNEF--------------KN---IFGTPEFVAPEIVN----YEP--LGLEADMWSIGVITYILLS-GA-SP---------------FLGE------TKQETL----TN----ISA---VN---YDFDEEYFSNTS-------------------------ELAKD-FIRRLLVKDPKRRMTIAQSLEHSWI---------
----LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPV-LVAVKML---R-A--D-AN----KNARN-DFL-K-----EIKIMSRL--K---DPNIIHLLAVCI--T-------DDPLCMITEYMENGDLNQFLS---------RHEPPN-----------------------------------------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSSL--NFVHRDLATRNCLVGK-----NYTI----KIADFGMSRNL-------Y----S--GDYY--------------RIQGRAVLPIRWMSWESIL----LGK--FTTASDVWAFGVTLWETFTFCQEQP---------------YSQL---SDEQVIENT----GEFFRDQGRQTYLP---QPAICP-------------------------------DSVYK-LMLSCWRRDTKNRPSFQEIHL---LL--------
---K--LGQELGRGQYGVVYLCDNW----------------GGHF-PCALKSV---VPP--D-EKH---WN--D---LAL-----EFHYMRSL-PK---HERLVDLHGSVI--DYNYGGGSSIAVLLIMERLHR-DLYTGLK----------A----------------------------------------------------------------------------------------------------GLTLETRLQIALDVVEGIRFLHSQ--GLVHRDIKLKNVLLDK-----QNRA----KITDLGFCK---------------PEAMMS--------------GS---IVGTPIHMAPELFT-----GK--YDNSVDVYAFGILFWYICS-GS-VK---------------LPEAF-ERCASKDHLW----NN----VRR---GA---RPERLPVF---D-------------------------EECWQ-LMEACWDGDPLKRP-----------LLGIVQPML
---F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKI-PVAIKEL---R-E--A-TS----PKANK-EIL-D-----EAYVMASV--D---NPHVCRLLGICL----------TSTVQLITQLMPFGCLLDYVR---------EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR--RLVHRDLAARNVLVKT-----PQHV----KITDFGLAKLL-------G----A--EEKE--------------YHAEGGKVPIKWMALESIL----HRI--YTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI---PASEISSIL----EK----GER---LP---QPPICT-------------------------------IDVYM-IMVKCWMIDADSRPKFRELI----IEF-------
---I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEI-SVAIKTL---K-V--G-YT----EKQRR-DFL-G-----EASIMGQF--D---HPNIIRLEGVVT--K-------SKPVMIVTEYMENGSLDSFLR---------KH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDM--GYVHRDLAARNILINS-----NLVC----KVSDFGLSRVL-------E----D--DPEA-------------AYTTRGGKIPIRWTSPEAIA----YRK--FTSASDVWSYGIVLWEVMSYGE-RP---------------YWEM---SNQDVIKAV----DE----GYR---LP---PPMDCP-------------------------------AALYQ-LMLDCWQKDRNNRPKFEQIVSIL-----------
---V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREI-YVAIKTL---K-A--G-YS----EKQRR-DFL-S-----EASIMGQF--D---HPNIIRLEGVVT--K-------SRPVMIITEFMENGALDSFLR---------QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEM--NYVHRDLAARNILVNS-----NLVC----KVSDFGLSRYLQ----DDT----S--DPTY--------------TSSLGGKIPVRWTAPEAIA----YRK--FTSASDVWSYGIVMWEVMSFGE-RP---------------YWDM---SNQDVINAI----EQ----DYR---LP---PPMDCP-------------------------------AALHQ-LMLDCWQKDRNSRPRFAEIVNTL-----------
---V-KIEEVIGAGEFGEVCRGRLK-------------APGKKES-CVAIKTL---K-G--G-YT----ERQRR-EFL-S-----EASIMGQF--E---HPNIIRLEGVVT--N-------SMPVMILTEFMENGALDSFLR---------LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEM--SYVHRDLAARNILVNS-----NLVC----KVSDFGLSRFLE----ENS----S--DPTY--------------TSSLGGKIPIRWTAPEAIA----FRK--FTSASDAWSYGIVMWEVMSFGE-RP---------------YWDM---SNQDVINAI----EQ----DYR---LP---PPPDCP-------------------------------TSLHQ-LMLDCWQKDRNARPRFPQVVSAL-----------
----IKIEEVIGTGSFGEVRQGRLQ-------------PRGRREQ-TVAIQAL---W-A--G-GA----ESLQM-TFL-G-----RAAVLGQF--Q---HPNILRLEGVVT--K-------SRPLMVLTEFMELGPLDSFLR---------QR--------------------------------------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSF--AFVHRSLSAHSVLVNS-----HLVC----KVARLGHSPQG--------------------------------------PSCLLRWAAPEVIA----HGK--HTTSSDVWSFGILMWEVMSYGE-RP---------------YWDM---SEQEVLNAI----EQ----EFR---LP---PPPGCP-------------------------------PGLHL-LMLDTWQKDRARRPHFDQLVA---AF--------
---L-KRVKVLGSGAFGTVYKGIWVP------------EGETVKI-PVAIKIL---N-E--T-TG----PKANV-EFM-D-----EALIMASM--D---HPHLVRLLGVCL----------SPTIQLVTQLMPHGCLLEYVH---------EH--------------------------------------------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEER--RLVHRDLAARNVLVKS-----PNHV----KITDFGLARLL-------E----G--DEKE--------------YNADGGKMPIKWMALECIH----YRK--FTHQSDVWSYGVTIWELMTFGG-KP---------------YDGI---PTREIPDLL----EK----GER---LP---QPPICT-------------------------------IDVYM-VMVKCWMIDADSRPKFKELAAE--F---------
--VI--LGELLGKGNFGEVYKGTLK-----------------DKT-SVAVKTC---K-E--D-LP----QELKI-KFL-Q-----EAKILKQY--D---HPNIVKLIGVCT--Q-------RQPVYIIMELVSGGDFLTFLR---------RK--------------------------------------------------------------------------------------------------KDELKLKQLVKFSLDAAAGMLYLESK--NCIHRDLAARNCLVGE-----NNVL----KISDFGMSRQE------------D--GGVY--------------SSSGLKQIPIKWTAPEALN----YGR--YSSESDVWSFGILLWETFSLGV-CP---------------YPGM---TNQQAREQV----ER----GYR---MS---APQHCP-------------------------------EDISK-IMMKCWDYKPENRPKFSELQKEL-----------
---L-VLGEQIGRGNFGEVFSGRLR----------------ADNT-LVAVKSC---R-E--T-LP----PDLKA-KFL-Q-----EARILKQY--S---HPNIVRLIGVCT--Q-------KQPIYIVMELVQGGDFLTFLR---------TE--------------------------------------------------------------------------------------------------GARLRVKTLLQMVGDAAAGMEYLESK--CCIHRDLAARNCLVTE-----KNVL----KISDFGMSREE-------A----D--GVYA--------------ASGGLRQVPVKWTAPEALN----YGR--YSSESDVWSFGILLWETFSLGA-SP---------------YPNL---SNQQTREFV----EK----GGR---LP---CPELCP-------------------------------DAVFR-LMEQCWAYEPGQRPSFSTIYQEL-----------
----LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAV-TVAVKML---K-D--D-AT----EKDLS-DLV-S-----EMEMMKMIG-K---HKNIINLLGACT--Q-------DGPLYVIVEYASKGNLREYLR---------ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ--KCIHRDLAARNVLVTE-----NNVM----KIADFGLARDI-------N----N--IDYY--------------KKTTNGRLPVKWMAPEALF----DRV--YTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI---PVEELFKLL----KE----GHR---MD---KPANCT-------------------------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL-----------
----LTLGKPLGEGCFGQVVMAEAIGI---------DKDRAAKPV-TVAVKML---K-D--D-AT----DKDLS-DLV-S-----EMEMMKMIG-K---HKNIINLLGACT--Q-------GGPLYVLVEYAAKGNLREFLR---------ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQ--KCIHRDLAARNVLVTE-----DNVM----KIADFGLARDV-------H----N--LDYY--------------KKTTNGRLPVKWMAPEALF----DRV--YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI---PVEELFKLL----KE----GHR---MD---KPANCT-------------------------------HDLYM-IMRECWHAAPSQRPTFKQLVEDL-----------
---L-VLGKPLGEGCFGQVVRAEAFGM---------DPARPDQAS-TVAVKML---K-D--N-AS----DKDLA-DLV-S-----EMEVMKLIG-R---HKNIINLLGVCT--Q-------EGPLYVIVECAAKGNLREFLR---------ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESR--KCIHRDLAARNVLVTE-----DNVM----KIADFGLARGV-------H----H--IDYY--------------KKTSNGRLPVKWMAPEALF----DRV--YTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI---PVEELFSLL----RE----GHR---MD---RPPHCP-------------------------------PELYG-LMRECWHAAPSQRPTFKQLVEAL-----------
----LKLEKKLGAGQFGEVWMATYN-----------------KHT-KVAVKTM---K-P--G-SM----SV--E-AFL-A-----EANVMKTL--Q---HDKLVKLHAVVT----------KEPIYIITEFMAKGSLLDFLK---------SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR--NYIHRDLRAANILVSA-----SLVC----KIADFGLARVI------------E--DNEY--------------TAREGAKFPIKWTAPEAIN----FGS--FTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM---SNPEVIRAL----ER----GYR---MP---RPENCP-------------------------------EELYN-IMMRCWKNRPEERPTFEYIQSV--L---------
----YTTIRQLGDGTYGSVLLGRSI----------------ESGE-LIAIKKM---KRK--F-YSW---EE--C--MNLR-----EVKSLKKL--N---HANVVKLKEVIR--E-------NDHLYFIFEYMKE-NLYQLIK-------ERNK----------------------------------------------------------------------------------------------------LFPESAIRNIMYQILQGLAFIHKH--GFFHRDLKPENLLCMG-----PELV----KIADFGLARE-------------IRSKPPY--------------TD---YVSTRWYRAPEVLL---RSTN--YSSPIDVWAVGCIMAEVYT-LR-PL---------------FPGA---SEIDTIFKI----CQ----VLG---TP---KKTDWPEGYQLSSAMNFRWPQCV--PNNLKTLIPNASSEAVQ-LLRDMLQWDPKKRPTASQALRYPYF---------
----ITMSRELGQGSFGMVYEGVAKG-----------VVKDEPET-RVAIKTV---N-E--A-AS----MRERI-EFL-N-----EASVMKEF--N---CHHVVRLLGVVS--Q-------GQPTLVIMELMTRGDLKSYLR---------SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNAN--KFVHRDLAARNCMVAE-----DFTV----KIGDFGMTRDI-------Y----E--TDYY--------------RKGGKGLLPVRWMSPESLK----DGV--FTTYSDVWSFGVVLWEIATLAE-QP---------------YQGL---SNEQVLRFV----ME----GGL---LD---KPDNCP-------------------------------DMLFE-LMRMCWQYNPKMRPSFLEIISS--I---------
----ITLLRELGQGSFGMVYEGNARD-----------IIKGEAET-RVAVKTV---N-E--S-AS----LRERI-EFL-N-----EASVMKGF--T---CHHVVRLLGVVS--K-------GQPTLVVMELMAHGDLKSYLR---------SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK--KFVHRDLAARNCMVAH-----DFTV----KIGDFGMTRDI-------Y----E--TDYY--------------RKGGKGLLPVRWMAPESLK----DGV--FTTSSDMWSFGVVLWEITSLAE-QP---------------YQGL---SNEQVLKFV----MD----GGY---LD---QPDNCP-------------------------------ERVTD-LMRMCWQFNPKMRPTFLEIVNLL-----------
---I-SIIRELGQGSFGMVYEGLARG-----------LEAGEEST-PVALKTV---N-E--L-AS----PRECI-EFL-K-----EASVMKAF--K---CHHVVRLLGVVS--Q-------GQPTLVIMELMTRGDLKSHLR---------SLRPEA-----------------------------------------------------------------------------------------ENNPGLPQPALGEMIQMAGEIADGMAYLAAN--KFVHRDLAARNCMVSQ-----DFTV----KIGDFGMTRDV-------Y----E--TDYY--------------RKGGKGLLPVRWMAPESLK----DGI--FTTHSDVWSFGVVLWEIVTLAE-QP---------------YQGL---SNEQVLKFV----MD----GGV---LE---ELEGCP-------------------------------LQLQE-LMSRCWQPNPRLRPSFTHILD---SI--------
-VGG----NKMGEGGFGVVYKGYVN----------------NTT---VAVKKL---AAM--V-DIT---TE--ELKQQFD----QEIKVMAKC--Q---HENLVELLGFSS--D-------GDDLCLVYVYMPNGSLLDRLSC-----LDGTP----------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN--HHIHRDIKSANILLDE-----AFTA----KISDFGLARASE----------KFAQTVMT--------------SR---IVGTTAYMAPEALR-----GE--ITPKSDIYSFGVVLLEIIT-GL-PA---------------VDEH---REPQLLLDI----KE----EIE---DE---EKTIEDYIDKKMNDAD-----------------STSVEAMYS-VASQCLHEKKNKRPDIKKVQQ----LLQ------
----LTFVQEIGSGQFGLVHLGYWL-----------------NKD-KVAIKTI---R-E--G-AM----SE--E-DFI-E-----EAEVMMKL--S---HPKLVQLYGVCL--E-------QAPICLVFEFMEHGCLSDYLR---------TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEA--CVIHRDLAARNCLVGE-----NQVI----KVSDFGMTRFV------------L--DDQY--------------TSSTGTKFPVKWASPEVFS----FSR--YSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR---SNSEVVEDI----ST----GFR---LY---KPRLAS-------------------------------THVYQ-IMNHCWKERPEDRPAFSRLLRQL-----------
----LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGE-VVAVKKL---Q-H--S-TE-----EHLR-DFE-R-----EIEILKSL--Q---HDNIVKYKGVCYSAG-------RRNLKLIMEYLPYGSLRDYLQ---------KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK--RYIHRDLATRNILVEN-----ENRV----KIGDFGLTKVL------PQ----D--KEYY--------------KVKEPGESPIFWYAPESLT----ESK--FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM---IVFHLIELL----KN----NGR---LP---RPDGCP-------------------------------DEIYM-IMTECWNNNVNQRPSFRDLA----LRV-------
----LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAM-TVAVKML---K-P--S-AH----LTERE-ALM-S-----ELKVLSYLG-N---HMNIVNLLGACT--I-------GGPTLVITEYCCYGDLLNFLR---------RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK--NCIHRDLAARNILLTH-----GRIT----KICDFGLARDI-------K----N--DSNY--------------VVKGNARLPVKWMAPESIF----NCV--YTFESDVWSYGIFLWELFSLGS-SP---------------YPGM-P-VDSKFYKMI----KE----GFR---ML---SPEHAP-------------------------------AEMYD-IMKTCWDADPLKRPTFKQIVQL--I---------
----LKLVERLGAGQFGEVWMGYYN-----------------GHT-KVAVKSL---K-Q--G-SM----SP--D-AFL-A-----EANLMKQL--Q---HQRLVRLYAVVT----------QEPIYIITEYMENGSLVDFLK---------TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER--NYIHRDLRAANILVSD-----TLSC----KIADFGLARLI------------E--DNEY--------------TAREGAKFPIKWTAPEAIN----YGT--FTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM---TNPEVIQNL----ER----GYR---MV---RPDNCP-------------------------------EELYQ-LMRLCWKERPEDRPTFDYLRSV--L---------
---V-TLLRALGHGAFGEVYEGLVIG-----------LPGDSSPL-QVAIKTL---P-E--L-CS----PQDEL-DFL-M-----EALIISKF--R---HQNIVRCVGLSL--R-------ATPRLILLELMSGGDMKSFLR---------HSRP--------------------------------------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEEN--HFIHRDIAARNCLLSCA--GPSRVA----KIGDFGMARDI-------Y----R--ASYY--------------RRGDRALLPVKWMPPEAFL----EGI--FTSKTDSWSFGVLLWEIFSLGY-MP---------------YPGR---TNQEVLDFV----VG----GGR---MD---PPRGCP-------------------------------GPVYR-IMTQCWQHEPELRPSFASILERL-----------
----YTTMRQLGDGTYGSVLMGKSN----------------ESGE-LVAIKRM---KRK--F-YSW---DE--C-M-NLR-----EVKSLKKL--N---HANVIKLKEVIR--E-------NDHLYFIFEYMKE-NLYQLMK-------DRNK----------------------------------------------------------------------------------------------------LFPESVIRNIMYQILQGLAFIHKH--GFFHRDMKPENLLCMG-----PELV----KIADFGLARE-------------LRSQPPY--------------TD---YVSTRWYRAPEVLL---RSSV--YSSPIDVWAVGSIMAELYM-LR-PL---------------FPGT---SEVDEIFKI----CQ----VLG---TP---KKSDWPEGYQLASSMNFRFPQCV--PINLKTLIPNASNEAIQ-LMTEMLNWDPKKRPTASQALKHPYF---------
----LTLGAQIGEGEFGAVLQGEYL------------------GQ-KVAVKNI---K-C--D-VT----AQ----AFL-D-----ETAVMTKM--Q---HENLVRLLGVIL----------HQGLYIVMEHVSKGNLVNFLR---------TR-------------------------------------------------------------------------------------------------GRALVNTAQLLQFSLHVAEGMEYLESK--KLVHRDLAARNILVSE-----DLVA----KVSDFGLAKAE------------------R--------------KGLDSSRLPVKWTAPEALK----HGK--FTSKSDVWSFGVLLWEVFSYGR-AP---------------YPKM---SLKEVSEAV----EK----GYR---ME---PPEGCP-------------------------------GPVHV-LMSSCWEAEPARRPPFRKLAEKL-----------
----VHFNEVIGRGHFGCVYHGTLL-------------DNDGKKI-HCAVKSL---N-R--I-TD----IGEVS-QFL-T-----EGIIMKDF--S---HPNVLSLLGICL-RS-------EGSPLVVLPYMKHGDLRNFIR---------NE--------------------------------------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASK--KFVHRDLAARNCMLDE-----KFTV----KVADFGLARDM-------Y----D--KEYYS------------VHNKTGAKLPVKWMALESLQ----TQK--FTTKSDVWSFGVLLWELMTRGA-PP---------------YPDV---NTFDITVYL----LQ----GRR---LL---QPEYCP-------------------------------DPLYE-VMLKCWHPKAEMRPSFSELVSR--I---------
---I-EYVRDIGEGAFGRVFQARAPG-----------LLPYEPFT-MVAVKML---K-E--E-AS----ADMQA-DFQ-R-----EAALMAEF--D---NPNIVKLLGVCA--V-------GKPMCLLFEYMAYGDLNEFLR---------SMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSER--KFVHRDLATRNCLVGE-----NMVV----KIADFGLSRNI-------Y----S--ADYY--------------KANENDAIPIRWMPPESIF----YNR--YTTESDVWAYGVVLWEIFSYGL-QP---------------YYGM---AHEEVIYYV----RD----GNI---LS---CPENCP-------------------------------VELYN-LMRLCWSKLPADRPSFTSIHRIL-----------
---Y-VRLQKIGEGSFGKAILVKST----------------EDGR-QYVIKEI---NIS--R-MSS---KE--R-EESRR-----EVAVLANM--K---HPNIVQYRESFE--E-------NGSLYIVMDYCEGGDLFKRINA------QKGV----------------------------------------------------------------------------------------------------LFQEDQILDWFVQICLALKHVHDR--KILHRDIKSQNIFLTK-----DGTV----QLGDFGIARVL------------NSTVELA--------------RT---CIGTPYYLSPEICE----NKP--YNNKSDIWALGCVLYELCT-LK-HA---------------FEAG------SMKNLV----LK----IIS---GS---FPPVSLHYS----------------------------YDLRS-LVSQLFKRNPRDRPSVNSILEKGF-I--------
--IV--LKWELGEGAFGKVFLAECHN-----------LLPEQDKM-LVAVKAL---K-E--A-SE----SA-RQ-DFQ-R-----EAELLTML--Q---HQHIVRFFGVCT--E-------GRPLLMVFEYMRHGDLNRFLR---------SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGL--HFVHRDLATRNCLVGQ-----GLVV----KIGDFGMSRDI-------Y----S--TDYY--------------RVGGRTMLPIRWMPPESIL----YRK--FTTESDVWSFGVVLWEIFTYGK-QP---------------WYQL---SNTEAIDCI----TQ----GRE---LE---RPRACP-------------------------------PEVYA-IMRGCWQREPQQRHSIKDVHARL-----------
---I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKI-LVAVKTL---K-D--A-SD----NA-RK-DFH-R-----EAELLTNL--Q---HEHIVKFYGVCV--E-------GDPLIMVFEYMKHGDLNKFLR---------AHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQ--HFVHRDLATRNCLVGE-----NLLV----KIGDFGMSRDV-------Y----S--TDYY--------------RVGGHTMLPIRWMPPESIM----YRK--FTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL---SNNEVIECI----TQ----GRV---LQ---RPRTCP-------------------------------QEVYE-LMLGCWQREPHMRKNIKGIHTL--L---------
---I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKM-LVAVKAL---K-D--P-TL----AA-RK-DFQ-R-----EAELLTNL--Q---HEHIVKFYGVCG--D-------GDPLIMVFEYMKHGDLNKFLR---------AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQ--HFVHRDLATRNCLVGA-----NLLV----KIGDFGMSRDV-------Y----S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM----YRK--FTTESDVWSFGVILWEIFTYGK-QP---------------WFQL---SNTEVIECI----TQ----GRV---LE---RPRVCP-------------------------------KEVYD-VMLGCWQREPQQRLNIKEIYKIL-----------
----YELQEVIGSGATAVVQAAYCA----------------PKKE-KVAIKRI---NLE--K-CQT---SM--D-E-LLK-----EIQAMSQC--H---HPNIVSYYTSFV--V-------KDELWLVMKLLSGGSVLDIIKHIVAKGEHKSG----------------------------------------------------------------------------------------------------VLDESTIATILREVLEGLEYLHKN--GQIHRDVKAGNILLGE-----DGSV----QIADFGVSAFLAT-------GGDITRNKVR--------------KT---FVGTPCWMAPEVME---QVRG--YDFKADIWSFGITAIELAT-GA-AP---------------YHKY---PPMKVLMLT----LQ----NDP---PS---LETGVQDKE--MLK--------------------KYGKSFRK-MISLCLQKDPEKRPTAAELLRHKFF---------
----YTRFEKIGQGASGTVYTAMDV----------------ATGQ-EVAIKQM---NLQ--Q-QPK---KE--L-II--N-----EILVMREN--K---NPNIVNYLDSYL--V-------GDELWVVMEYLAGGSLTDVVT---------ET----------------------------------------------------------------------------------------------------CMDEGQIAAVCRECLQALEFLHSN--QVIHRDIKSDNILLGM-----DGSV----KLTDFGFCAQI------------TPEQSKR--------------ST---MVGTPYWMAPEVVT----RKA--YGPKVDIWSLGIMAIEMIE-GE-PP---------------YLNE---NPLRALYLI----AT----NGT---PE---LQNPEKLS-----------------------------AIFRD-FLNRCLEMDVEKRGSAKELLQHQFL---------
----YTRFEKIGQGASGTVYTALDI----------------ATGQ-EVAIKQM---NLQ--Q-QPK---KE--L-II--N-----EILVMREN--K---NPNIVNYLDSYL--V-------GDELWVVMEYLAGGSLTDVVT---------ET----------------------------------------------------------------------------------------------------CMDEGQIAAVCRECLQALDFLHSN--QVIHRDIKSDNILLGM-----DGSV----KLTDFGFCAQI------------TPEQSKR--------------ST---MVGTPYWMAPEVVT----RKA--YGPKVDIWSLGIMAIEMVE-GE-PP---------------YLNE---NPLRALYLI----AT----NGT---PE---LQNPERLS-----------------------------AVFRD-FLNRCLEMDVDRRGSAKELLQHPFL---------
---Y-IKLEKLGEGTYATVYKGRSK----------------LTEN-LVALKEI---RLE--H-EEG---AP--C--TAIR-----EVSLLKDL--K---HANIVTLHDIVH--T-------DKSLTLVFEYLDK-DLKQYMD-------DCGN----------------------------------------------------------------------------------------------------IMSMHNVKLFLYQILRGLAYCHRR--KVLHRDLKPQNLLINE-----KGEL----KLADFGLARAK------------SVPTKTY--------------SN---EVVTLWYRPPDVLL---GSSE--YSTQIDMWGVGCIFFEMAS-GR-PL---------------FPGS---TVEDELHLI----FR----LLG---TP---SQETWPGISSNEEFKNYNFPKYK--PQPLINHAPRLDSEGIE-LITKFLQYESKKRVSAEEAMKHVYF---------
---L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVM-KVAVKML---K-P--T-AR----SSEKQ-ALM-S-----ELKIMTHLG-P---HLNIVNLLGACT--K-------SGPIYIITEYCFYGDLVNYLH---------KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASK--NCVHRDLAARNVLLAQ-----GKIV----KICDFGLARDI-------M----H--DSNY--------------VSKGSTFLPVKWMAPESIF----DNL--YTTLSDVWSYGILLWEIFSLGG-TP---------------YPGM-M-VDSTFYNKI----KS----GYR---MA---KPDHAT-------------------------------SEVYE-IMVKCWNSEPEKRPSFYHLSE---IV--------
---L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATM-KVAVKML---K-S--T-AR----SSEKQ-ALM-S-----ELKIMSHLG-P---HLNVVNLLGACT--K-------GGPIYIITEYCRYGDLVDYLH---------RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASK--NCVHRDLAARNVLICE-----GKLV----KICDFGLARDI-------M----R--DSNY--------------ISKGSTFLPLKWMAPESIF----NSL--YTTLSDVWSFGILLWEIFTLGG-TP---------------YPEL-P-MNEQFYNAI----KR----GYR---MA---QPAHAS-------------------------------DEIYE-IMQKCWEEKFEIRPPFSQLVL---LL--------
---V-VLNRILGEGFFGEVYEGVYT-------------NHKGEKI-NVAVKTC---K-K--D-CT----LDNKE-KFM-S-----EAVIMKNL--D---HPHIVKLIGIIE----------EEPTWIIMELYPYGELGHYLE---------RN--------------------------------------------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESI--NCVHRDIAVRNILVAS-----PECV----KLGDFGLSRYI------------E--DEDY--------------YKASVTRLPIKWMSPESIN----FRR--FTTASDVWMFAVCMWEILSFGK-QP---------------FFWL---ENKDVIGVL----EK----GDR---LP---KPDLCP-------------------------------PVLYT-LMTRCWDYDPSDRPRFTELVCS--L---------
---L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYT-TVAVKML---K-E--N-AS----PSELR-DLL-S-----EFNVLKQV--N---HPHVIKLYGACS--Q-------DGPLLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM--KLVHRDLAARNILVAE-----GRKM----KISDFGLSRDV-------Y----E--EDSY--------------VKRSQGRIPVKWMAIESLF----DHI--YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI---PPERLFNLL----KT----GHR---ME---RPDNCS-------------------------------EEMYR-LMLQCWKQEPDKRPVFADISKDL-----------
-LES----AELDSGGFGKVSLCFHR-----------------TQG-LMIMKTV--YK-G--P-NC----IEHNE-ALL-E-----EAKMMNRL--R---HSRVVKLLGVII--E-------EGKYSLVMEYMEKGNLMHVLK---------AE---------------------------------------------------------------------------------------------------MSTPLSVKGRIILEIIEGMCYLHGK--GVIHKDLKPENILVDN-----DFHI----KIADLGLASFKMWSKLNNE--------EHNELR--------EVDGTAKKNGGTLYYMAPEHLN----DVNAKPTEKSDVYSFAVVLWAIFA-NK-EP---------------YENA-I-CEQQLIMCI----KS----GNR---PDVDDITEYCP-------------------------------REIIS-LMKLCWEANPEARPTFPGIEEK--F---------
--LT--LRLLLGSGAFGEVYEGTAVDI----------LGVGSGEI-KVAVKTL---K-K--G-ST----DQEKI-EFL-K-----EAHLMSKF--N---HPNILKQLGVCL--L-------NEPQYIILELMEGGDLLTYLR---------KARM--------------------------------------------------------------------------------------------ATFYGPLLTLVDLVDLCVDISKGCVYLERM--HFIHRDLAARNCLVSVKDYTSPRIV----KIGDFGLARDI-------Y----K--NDYY--------------RKRGEGLLPVRWMAPESLM----DGI--FTTQSDVWSFGILIWEILTLGH-QP---------------YPAH---SNLDVLNYV----QT----GGR---LE---PPRNCP-------------------------------DDLWN-LMTQCWAQEPDQRPTFHRIQDQL-----------
---L-RLEVKLGQGCFGEVWMGTWN-----------------GTT-RVAIKTL---K-P--G-TM----SP--E-AFL-Q-----EAQVMKKL--R---HEKLVQLYAVVS----------EEPIYIVTEYMSKGSLLDFLK---------GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM--NYVHRDLRAANILVGE-----NLVC----KVADFGLARLI------------E--DNEY--------------TARQGAKFPIKWTAPEAAL----YGR--FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM---VNREVLDQV----ER----GYR---MP---CPPECP-------------------------------ESLHD-LMCQCWRKEPEERPTFEYLQAF--L---------
----FTKLEKIGKGSFGEVFKGIDN----------------RTQK-VVAIKII---DLE--E-AED---EI--E-DIQ-Q-----EITVLSQC--D---SPYVTKYYGSYL--K-------DTKLWIIMEYLGGGSALDLLE---------PG----------------------------------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSE--KKIHRDIKAANVLLSE-----HGEV----KLADFGVAGQL------------TDTQIKR--------------NT---FVGTPFWMAPEVIK----QSA--YDSKADIWSLGITAIELAR-GE-PP---------------HSEL---HPMKVLFLI----PK----NNP---PT---LEGNYS-------------------------------KPLKE-FVEACLNKEPSFRPTAKELLKHKFI---------
---F-DVLEKLGEGSYGSVFKAIHK----------------ESGQ-VVAIKQV---PVE--S-DLQ---EI-------IK-----EISIMQQC--D---SPYVVKYYGSYF--K-------NTDLWIVMEYCGAGSVSDIIR-------LRNK----------------------------------------------------------------------------------------------------TLIEDEIATILKSTLKGLEYLHFM--RKIHRDIKAGNILLNT-----EGHA----KLADFGVAGQL------------TDTMAKR--------------NT---VIGTPFWMAPEVIQ----EIG--YNCVADIWSLGITSIEMAE-GK-PP---------------YADI---HPMRAIFMI----PT----NPP---PT---FRKPELWS-----------------------------DDFTD-FVKKCLVKNPEQRATATQLLQHPFI---------
----YELQEVIGSGATAVVQAALCK----------------PRQE-RVAIKRI---NLE--K-CQT---SM--D-E-LLK-----EIQAMSQC--S---HPNVVTYYTSFV--V-------KDELWLVMKLLSGGSMLDIIKYIVNRGEHKNG----------------------------------------------------------------------------------------------------VLEEAIIATILKEVLEGLDYLHRN--GQIHRDLKAGNILLGE-----DGSV----QIADFGVSAFLAT-------GGDVTRNKVR--------------KT---FVGTPCWMAPEVME---QVRG--YDFKADMWSFGITAIELAT-GA-AP---------------YHKY---PPMKVLMLT----LQ----NDP---PT---LETGVEDKE--MMK--------------------KYGKSFRK-LLSLCLQKDPSKRPTAAELLKCKFF---------
---F-DVLEKLGEGSYGSVYKAIHK----------------ETGQ-IVAIKQV---PVE--S-DLQ---EI-------IK-----EISIMQQC--D---SPHVVKYYGSYF--K-------NTDLWIVMEYCGAGSVSDIIR-------LRNK----------------------------------------------------------------------------------------------------TLTEDEIATILQSTLKGLEYLHFM--RKIHRDIKAGNILLNT-----EGHA----KLADFGVAGQL------------TDTMAKR--------------NT---VIGTPFWMAPEVIQ----EIG--YNCVADIWSLGITAIEMAE-GK-PP---------------YADI---HPMRAIFMI----PT----NPP---PT---FRKPELWS-----------------------------DNFTD-FVKQCLVKSPEQRATATQLLQHPFV---------
---F-TDLREIGHGSFGAVYFARDV----------------RTNE-VVAIKKM---SYS--G-KQS---TE--K-WQDII----KEVKFLQRI--K---HPNSIEYKGCYL--R-------EHTAWLVMEYCLG-SASDLLE-------VHKK----------------------------------------------------------------------------------------------------PLQEVEIAAITHGALQGLAYLHSH--TMIHRDIKAGNILLTE-----PGQV----KLADFGSASM----------------ASPA--------------NS---FVGTPYWMAPEVILA-MDEGQ--YDGKVDVWSLGITCIELAE-RK-PP---------------LFNM---NAMSALYHI----AQ----NES---PT---LQSNEWS------------------------------DYFRN-FVDSCLQKIPQDRPTSEELLKHIF-V--------
--FS--DLREIGHGSFGAVYFARDV----------------RNSE-VVAIKKM---SYS--G-KQS---NE--K-WQDII----KEVRFLQKL--R---HPNTIQYRGCYL--R-------EHTAWLVMEYCLG-SASDLLE-------VHKK----------------------------------------------------------------------------------------------------PLQEVEIAAVTHGALQGLAYLHSH--NMIHRDVKAGNILLSE-----PGLV----KLGDFGSASI----------------MAPA--------------NS---FVGTPYWMAPEVILA-MDEGQ--YDGKVDVWSLGITCIELAE-RK-PP---------------LFNM---NAMSALYHI----AQ----NES---PV---LQSGHWS------------------------------EYFRN-FVDSCLQKIPQDRPTSEVLLKHRFV---------
FIGL----HEIGHGSFGAVYFATNA----------------HTSE-VVAIKKM---SYS--G-KQT---HE--K-WQDIL----KEVKFLRQL--K---HPNTIEYKGCYL--K-------EHTAWLVMEYCLG-SASDLLE-------VHKK----------------------------------------------------------------------------------------------------PLQEVEIAAITHGALHGLAYLHSH--ALIHRDIKAGNILLTE-----PGQV----KLADFGSASM----------------ASPA--------------NS---FVGTPYWMAPEVILA-MDEGQ--YDGKVDIWSLGITCIELAE-RK-PP---------------LFNM---NAMSALYHI----AQ----NDS---PT---LQSNEWTD------------------------------SFRR-FVDYCLQKIPQERPTSAELLRHDFV---------
--YL--LLHLLGRGGFSEVYKAFDL----------------TEQR-YVAVKIH---QLN--K-NWR---DE--K-KENYHKHACREYRIHKEL--D---HPRIVKLYDYFS--L------DTDSFCTVLEYCEGNDLDFYLK--------QHK----------------------------------------------------------------------------------------------------LMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVN-----GTACG-EIKITDFGLSKIMDDD-----SYNSVDGMELT--------------SQ---GAGTYWYLPPECFVVGKEPPK--ISNKVDVWSVGVIFYQCLY-GR-KP---------------FGHN----QSQQDILQ----EN----TIL---KA---TEVQFPPKPVVT-------------------------PEAKA-FIRRCLAYRKEDRIDVQQLACDPYL---------
-VCR---GELLGSGCFGVVHRGLWT-------------LPSGKSV-PVAVKSLRVGP-E--G-PM----GTELG-DFL-R-----EVSVMMNL--E---HPHVLRLHGLVL----------GQPLQMVMELAPLGSLHARLT---------AP------------------------------------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGAR--GLVHRDLATRNLLLAS-----PRTI----KVADFGLVRPL------GG----A--RGRY--------------VMGGPRPIPYAWCAPESLR----HGA--FSSASDVWMFGVTLWEMFSGGE-EP---------------WAGV---PPYLILQRL----ED----RAR---LP---RPPLCS-------------------------------RALYS-LALRCWAPHPADRPSFSHLE----GLL-------
---L-RLLEKLGDGSFGVVRRGEWD-------------APSGKTV-SVAVKCL---K-PDVL-SQ----PEAMD-DFI-R-----EVNAMHSL--D---HRNLIRLYGVVL----------TPPMKMVTELAPLGSLLDRLR---------KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK--RFIHRDLAARNLLLAT-----RDLV----KIGDFGLMRAL------PQ----N--DDHY--------------VMQEHRKVPFAWCAPESLK----TRT--FSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL---NGSQILHKI---DKE----GER---LP---RPEDCP-------------------------------QDIYN-VMVQCWAHKPEDRPTFVALRDF--L---------
---L-RLEVKLGQGCFGEVWMGTWN-----------------GTT-KVAIKTL---K-P--G-TM----MP--E-AFL-Q-----EAQIMKKL--R---HDKLVPLYAVVS----------EEPIYIVTEFMSKGSLLDFLK---------EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERM--NYIHRDLRAANILVGE-----NLVC----KIADFGLARLI------------E--DNEY--------------TARQGAKFPIKWTAPEAAL----YGR--FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM---VNREVLEQV----ER----GYR---MP---CPQGCP-------------------------------ESLHE-LMNLCWKKDPDERPTFEYIQSFL-----------
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