|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK DDR1 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK AXL 527
TK BLK 241
TKL BMPR1B 204
TK BMX 422
TKL BRAF 456
TK BTK 402
CMGC CDKL2 4
TK CSF1R 582
TK CSK 195
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
TK DDR2 563
TK EGFR 712
TK EPHA1 624
TK EPHA3 621
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB4 615
TK EPHB6 670
TK ERBB4 718
TK FER 563
TK FES 561
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FLT4 845
TK FRK 234
TK FYN 271
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK INSRR 979
TKL IRAK4 186
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK KDR 834
TK KIT 589
TK LCK 245
TKL LIMK1 339
TKL LIMK2 331
TK LTK 510
TK LYN 247
TK MERTK 587
TK MET 1078
TK MUSK 575
Other NEK1 4
Other NEK2 8
Other NEK3 4
Other NEK4 6
Other NEK5 4
Other NEK9 52
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
STE OXSR1 17
STE PAK4 321
TK PDGFRA 593
TK PDGFRB 600
AGC PDPK1 82
AGC PKN1 615
CAMK PRKD3 576
TK PTK6 191
TK RET 724
TK ROS1 1945
AGC RPS6KA1 62
AGC RPS6KA3 68
STE SLK 34
TK SRC 270
TK SRMS 230
STE STK10 36
CAMK STK17B 33
Other STK36 4
TK SYK 371
TK TEC 370
TK TNK1 116
TK TNK2 150
TK TXK 271
TK TYK2 589
TK TYRO3 518
TK YES1 277
TK ZAP70 338
----LRFKEKLGEGQFGEV---HLCEVDSPQDLVSLDFPLNVRKGHPL---LVAV-KIL---R-P--D-AT-KNA-RN-D-FL-K----EVKIMSRL--K---DPNIIRLLGVCV--Q----DDP------LCMITDYMENGDLNQFLS---------AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATL--------NFVHRDLATRNCLVGE-----NFTI----KIADFGMSRNL-------------Y---A--GDYY--------------RVQGRAVLPIRWMAWECIL------MGK---FTTASDVWAFGVTLWEVLMLCRA-------------QP---------------FGQL-----TDEQVIENAGEFFRD----QGRQ-VYLSRPPACP------------------------------QGLYE-LMLRCWSRESEQRPP-----FSQLHRFL-------------
----ITMKHKLGGGQYGEV---YEGVWK----------------KYSL---TVAV-KTL---K-E--D-TM-EV---E-E-FL-K----EAAVMKEI--K---HPNLVQLLGVCT--R----EPP------FYIITEFMTYGNLLDYLR---------EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGE-----NHLV----KVADFGLSRLM-----------------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNK---FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYELL----EK----DYR----MERPEGCP------------------------------EKVYE-LMRACWQWNPSDRPS-----FAEIHQA--F-----------
----ITMKHKLGGGQYGEV---YVGVWK----------------KYSL---TVAV-KTL---K-E--D-TM-EV---E-E-FL-K----EAAVMKEI--K---HPNLVQLLGVCT--L----EPP------FYIVTEYMPYGNLLDYLR---------EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGE-----NHVV----KVADFGLSRLM-----------------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNT---FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYDLL----EK----GYR----MEQPEGCP------------------------------PKVYE-LMRACWKWSPADRPS-----FAETHQA--F-----------
---I-TLIRGLGHGAFGEV---YEGQVSG-----------MPNDPSPL---QVAV-KTL---P-E--V-CS-EQD-EL-D-FL-M----EALIISKF--N---HQNIVRCIGVSL--Q----SLP------RFILLELMAGGDLKSFLR---------ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN--------HFIHRDIAARNCLLTCP--GPGRVA----KIGDFGMARDI-------------Y---R--ASYY--------------RKGGCAMLPVKWMPPEAFM------EGI---FTSKTDTWSFGVLLWEIFSLGY--------------MP---------------YPSK-----SNQEVLEFV----TS----GGR----MDPPKNCP------------------------------GPVYR-IMTQCWQHQPEDRPN-----FAIILER--I-----------
----FEIGRPLGKGKFGNV---YLAREK----------------QSKF---ILAL-KVL---FKA--QLEKAGV---E-H-QLRR----EVEIQSHL--R---HPNILRLYGYFH--D----ATR------VYLILEYAPLGTVYRELQ--------KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK--------RVIHRDIKPENLLLGS-----AGEL----KIADFGWSV-------------------HAPSSRR--------------TT---LCGTLDYLPPEMIE------GRM---HDEKVDLWSLGVLCYEFLV-GK--------------PP---------------FEAN--------TYQETY----KR----ISR----VEFTFPDFVT----------------------------EGARD-LISRLLKHNPSQRPM-----LREVLEHPWI-----------
----FEIGRPLGKGKFGNV---YLAREK----------------KSHF---IVAL-KVL---FKS--Q-IEKEG---V-E-HQLR---REIEIQAHL--H---HPNILRLYNYFY--D----RRR------IYLILEYAPRGELYKELQ--------KSC----------------------------------------------------------------------------------------------------TFDEQRTATIMEELADALMYCHGK--------KVIHRDIKPENLLLGL-----KGEL----KIADFGWSV-------------------HAPSLRR--------------KT---MCGTLDYLPPEMIE------GRM---HNEKVDLWCIGVLCYELLV-GN--------------PP---------------FESA--------SHNETY----RR----IVK----VDLKFPASVP----------------------------MGAQD-LISKLLRHNPSERLP-----LAQVSAHPWV-----------
----FEIGRPLGKGKFGNV---YLARLK----------------ESHF---IVAL-KVL---FKS--Q-IEKEG---L-E-HQLR---REIEIQAHL--Q---HPNILRLYNYFH--D----ARR------VYLILEYAPRGELYKELQ--------KSE----------------------------------------------------------------------------------------------------KLDEQRTATIIEELADALTYCHDK--------KVIHRDIKPENLLLGF-----RGEV----KIADFGWSV-------------------HTPSLRR--------------KT---MCGTLDYLPPEMIE------GRT---YDEKVDLWCIGVLCYELLV-GY--------------PP---------------FESA--------SHSETY----RR----ILK----VDVRFPLSMP----------------------------LGARD-LISRLLRYQPLERLP-----LAQILKHPWV-----------
---V-ALGKTLGEGEFGAV---MEGQLN--------------QDDSIL---KVAV-KTM---K-I-AI-CT-RSE-LE-D-FL-S----EAVCMKEF--D---HPNVMRLIGVCF--Q----GSERESFPAPVVILPFMKHGDLHSFLL---------YSRL---------------------------------------------------------------------------------------------GDQPVYLPTQMLVKFMADIASGMEYLSTK--------RFIHRDLAARNCMLNE-----NMSV----CVADFGLSKKI-------------Y---N--GDYY--------------RQGRIAKMPVKWIAIESLA------DRV---YTSKSDVWSFGVTMWEIATRGQ--------------TP---------------YPGV-----ENSEIYDYL----RQ----GNR----LKQPADCL------------------------------DGLYA-LMSRCWELNPQDRPS-----FTELREDL-------------
---L-RLVRKLGSGQFGEV---WMGYYK-----------------NNM---KVAI-KTL---K-E--G-TM-SP---E-A-FL-G----EANVMKAL--Q---HERLVRLYAVVT-------KEP------IYIVTEYMARGCLLDFLK---------TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERM--------NSIHRDLRAANILVSE-----ALCC----KIADFGLARII--------------------DSEY--------------TAQEGAKFPIKWTAPEAIH------FGV---FTIKADVWSFGVLLMEVVTYGR--------------VP---------------YPGM-----SNPEVIRNL----ER----GYR----MPRPDTCP------------------------------PELYRGVIAECWRSRPEERPT-----FEFLQSV--L-----------
---I-QMVKQIGKGRYGEV---WMGKWR----------------GEK-----VAV-KVF---FTT--E-EASWF---R-E-T-------EIYQTVLM--R---HENILGFIAADI--KGTGSWTQ------LYLITDYHENGSLYDYLK---------ST----------------------------------------------------------------------------------------------------TLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKK-----NGTC----CIADLGLAVKFIS-------------DTNEVDIPP--------------NT---RVGTKRYMPPEVLDESLNRNHFQ---SYIMADMYSFGLILWEVAR-RCVSGGIVEEYQLPYHD-------------------LVPSDPSYEDMREIV----CI----KKL----RPSFPNRWSSDECL------------------------RQMGK-LMTECWAHNPASRLT-----ALRVKK----TL---------
----ITLLKELGSGQFGVV---QLGKWK-----------------GQY---DVAV-KMI---K-E--G-SM-SE---D-E-FF-Q----EAQTMMKL--S---HPKLVKFYGVCS--K----EYP------IYIVTEYISNGCLLNYLR---------SH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESH--------QFIHRDLAARNCLVDR-----DLCV----KVSDFGMTRYV-----------------L--DDQY--------------VSSVGTKFPVKWSAPEVFH------YFK---YSSKSDVWAFGILMWEVFSLGK--------------QP---------------YDLY-----DNSQVVLKV----SQ----GHR----LYRPHLAS------------------------------DTIYQ-IMYSCWHELPEKRPT-----FQQLLSS--I-----------
----ITVGQRIGSGSFGTV---YKGKWH-------------------G---DVAV-KML---N-V-TA-PT-PQQ-LQ-A-FK-N----EVGVLRKT--R---HVNILLFMGYST-------KPQ------LAIVTQWCEGSSLYHHLH---------II--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAK--------SIIHRDLKSNNIFLHE-----DLTV----KIGDFGLATVK-------------S---R--WSGS--------------HQFEQLSGSILWMAPEVIR------MQDKNPYSFQSDVYAFGIVLYELMT-GQ--------------LP---------------YSNI-N---NRDQIIFMV----GR----GYLSPDLSKVRSNCP------------------------------KAMKR-LMAECLKKKRDERPL-----FPQILA---SI----------
----LTFLKELGTGQFGVV---KYGKWR-----------------GQY---DVAI-KMI---K-E--G-SM-SE---D-E-FI-E----EAKVMMNL--S---HEKLVQLYGVCT--K----QRP------IFIITEYMANGCLLNYLR---------EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESK--------QFLHRDLAARNCLVND-----QGVV----KVSDFGLSRYV-----------------L--DDEY--------------TSSVGSKFPVRWSPPEVLM------YSK---FSSKSDIWAFGVLMWEIYSLGK--------------MP---------------YERF-----TNSETAEHI----AQ----GLR----LYRPHLAS------------------------------EKVYT-IMYSCWHEKADERPT-----FKILLSN--I-----------
----YENLGLVGEGSYGMV---MKCRNK----------------DTGR---IVAI-KKF---LES--D-DDKMV---K-K-IAMR----EIKLLKQL--R---HENLVNLLEVCK--K----KKR------WYLVFEFVDHTILDDLEL--------FPN----------------------------------------------------------------------------------------------------GLDYQVVQKYLFQIINGIGFCHSH--------NIIHRDIKPENILVSQ-----SGVV----KLCDFGFARTL-----------------AAPGEVY--------------TD---YVATRWYRAPELLV-----GDVK---YGKAVDVWAIGCLVTEMFM-GE--------------PL---------------FPGD-----SDIDQLYHI----MM----CLG----NLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVID-LAKKCLHIDPDKRPF-----CAELLHHDFF-----------
----LQFGKTLGAGAFGKV---VEATAFG-----------LGKEDAVL---KVAV-KML---K-S--T-AH-ADE-KE-A-LM-S----ELKIMSHLG-Q---HENIVNLLGACT--H----GGP------VLVITEYCCYGDLLNFLR---------RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASK--------NCIHRDVAARNVLLTN-----GHVA----KIGDFGLARDI-------------M---N--DSNY--------------IVKGNARLPVKWMAPESIF------DCV---YTVQSDVWSYGILLWEIFSLGL--------------NP---------------YPGI-L---VNSKFYKLV----KD----GYQ----MAQPAFAP------------------------------KNIYS-IMQACWALEPTHRPT-----FQQICSFL-------------
----LKLLQTIGKGEFGDV---MLGDYR------------------GN---KVAV-KCI---K-N--D-AT-AQ-----A-FL-A----EASVMTQL--R---HSNLVQLLGVIV-EE----KGG------LYIVTEYMAKGSLVDYLR---------SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGN--------NFVHRDLAARNVLVSE-----DNVA----KVSDFGLTKEA-----------------------S--------------STQDTGKLPVKWTAPEALR------EKK---FSTKSDVWSFGILLWEIYSFGR--------------VP---------------YPRI-----PLKDVVPRV----EK----GYK----MDAPDGCP------------------------------PAVYE-VMKNCWHLDAAMRPS-----FLQLREQL-------------
----YDTGEELGSGQFAVV---KKCREK----------------STGL---QYAA-KFI---KKR--R-TKSSR---R-G-VSREDIEREVSILKEI--Q---HPNVITLHEVYE--N----KTD------VILILELVAGGELFDFLA--------EKE----------------------------------------------------------------------------------------------------SLTEEEATEFLKQILNGVYYLHSL--------QIAHFDLKPENIMLLD-----RNVPKPRIKIIDFGLAHK------------------IDFGNEF--------------KN---IFGTPEFVAPEIVN------YEP---LGLEADMWSIGVITYILLS-GA--------------SP---------------FLGD--------TKQETL----AN----VSA----VNYEFEDEYFSNTS------------------------ALAKD-FIRRLLVKDPKKRMT-----IQDSLQHPWI-----------
----YDIGEELGSGQFAIV---KKCREK----------------STGL---EYAA-KFI---KKR--Q-SRASR---R-G-VSREEIEREVSILRQV--L---HHNVITLHDVYE--N----RTD------VVLILELVSGGELFDFLA--------QKE----------------------------------------------------------------------------------------------------SLSEEEATSFIKQILDGVNYLHTK--------KIAHFDLKPENIMLLD-----KNIPIPHIKLIDFGLAHE------------------IEDGVEF--------------KN---IFGTPEFVAPEIVN------YEP---LGLEADMWSIGVITYILLS-GA--------------SP---------------FLGD--------TKQETL----AN----ITA----VSYDFDEEFFSQTS------------------------ELAKD-FIRKLLVKETRKRLT-----IQEALRHPWI-----------
----YEMGEELGSGQFAIV---RKCRQK----------------GTGK---EYAA-KFI---KKR--R-LSSSR---R-G-VSREEIEREVNILREI--R---HPNIITLHDIFE--N----KTD------VVLILELVSGGELFDFLA--------EKE----------------------------------------------------------------------------------------------------SLTEDEATQFLKQILDGVHYLHSK--------RIAHFDLKPENIMLLD-----KNVPNPRIKLIDFGIAHK------------------IEAGNEF--------------KN---IFGTPEFVAPEIVN------YEP---LGLEADMWSIGVITYILLS-GA--------------SP---------------FLGE--------TKQETL----TN----ISA----VNYDFDEEYFSNTS------------------------ELAKD-FIRRLLVKDPKRRMT-----IAQSLEHSWI-----------
----LTFKEKLGEGQFGEV---HLCEVEGMEKFKDKDFALDVSANQPV---LVAV-KML---R-A--D-AN-KNA-RN-D-FL-K----EIKIMSRL--K---DPNIIHLLAVCI--T----DDP------LCMITEYMENGDLNQFLS---------RHEPPN-----------------------------------------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSSL--------NFVHRDLATRNCLVGK-----NYTI----KIADFGMSRNL-------------Y---S--GDYY--------------RIQGRAVLPIRWMSWESIL------LGK---FTTASDVWAFGVTLWETFTFCQE-------------QP---------------YSQL-----SDEQVIENT----GEFFRDQGRQ-TYLPQPAICP------------------------------DSVYK-LMLSCWRRDTKNRPS-----FQEIHL---LL----------
---F-KKIKVLGSGAFGTV---YKGLWIP------------EGEKVKI---PVAI-KEL---R-E--A-TS-PKA-NK-E-IL-D----EAYVMASV--D---NPHVCRLLGICL-------TST------VQLITQLMPFGCLLDYVR---------EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR--------RLVHRDLAARNVLVKT-----PQHV----KITDFGLAKLL-------------G---A--EEKE--------------YHAEGGKVPIKWMALESIL------HRI---YTHQSDVWSYGVTVWELMTFGS--------------KP---------------YDGI-----PASEISSIL----EK----GER----LPQPPICT------------------------------IDVYM-IMVKCWMIDADSRPK-----FRELI----IEF---------
--LM--VDTVIGEGEFGEV---YRGTLR-------------LPSQDCK---TVAI-KTL---K-D--T-SP-GGQ-WW-N-FL-R----EATIMGQF--S---HPHILHLEGVVT--K----RKP------IMIITEFMENGALDAFLR---------ER--------------------------------------------------------------------------------------------------EDQLVPGQLVAMLQGIASGMNYLSNH--------NYVHRDLAARNILVNQ-----NLCC----KVSDFGLTRLL-------------D---D--FDGT--------------YETQGGKIPIRWTAPEAIA------HRI---FTTASDVWSFGIVMWEVLSFGD--------------KP---------------YGEM-----SNQEVMKSI----ED----GYR----LPPPVDCP------------------------------APLYE-LMKNCWAYDRARRPH-----FQKLQAHL-------------
---I-SIDKVVGAGEFGEV---CSGRLK-------------LPSKKEI---SVAI-KTL---K-V--G-YT-EKQ-RR-D-FL-G----EASIMGQF--D---HPNIIRLEGVVT--K----SKP------VMIVTEYMENGSLDSFLR---------KH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDM--------GYVHRDLAARNILINS-----NLVC----KVSDFGLSRVL-------------E---D--DPEA-------------AYTTRGGKIPIRWTSPEAIA------YRK---FTSASDVWSYGIVLWEVMSYGE--------------RP---------------YWEM-----SNQDVIKAV----DE----GYR----LPPPMDCP------------------------------AALYQ-LMLDCWQKDRNNRPK-----FEQIVSIL-------------
----IHIEKIIGSGDSGEV---CYGRLR-------------VPGQRDV---PVAI-KAL---K-A--G-YT-ERQ-RR-D-FL-S----EASIMGQF--D---HPNIIRLEGVVT--R----GRL------AMIVTEYMENGSLDTFLR---------TH--------------------------------------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSDL--------GYVHRDLAARNVLVDS-----NLVC----KVSDFGLSRVL-------------E---D--DPDA-------------AYTTTGGKIPIRWTAPEAIA------FRT---FSSASDVWSFGVVMWEVLAYGE--------------RP---------------YWNM-----TNRDVISSV----EE----GYR----LPAPMGCP------------------------------HALHQ-LMLDCWHKDRAQRPR-----FSQIVSVL-------------
---V-KIEEVIGAGEFGEV---YKGRLK-------------LPGKREI---YVAI-KTL---K-A--G-YS-EKQ-RR-D-FL-S----EASIMGQF--D---HPNIIRLEGVVT--K----SRP------VMIITEFMENGALDSFLR---------QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEM--------NYVHRDLAARNILVNS-----NLVC----KVSDFGLSRYLQ----------DDT---S--DPTY--------------TSSLGGKIPVRWTAPEAIA------YRK---FTSASDVWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDVINAI----EQ----DYR----LPPPMDCP------------------------------AALHQ-LMLDCWQKDRNSRPR-----FAEIVNTL-------------
---V-KIEQVIGAGEFGEV---CSGHLK-------------LPGKREI---FVAI-KTL---K-S--G-YT-EKQ-RR-D-FL-S----EASIMGQF--D---HPNVIHLEGVVT--K----STP------VMIITEFMENGSLDSFLR---------QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADM--------NYVHRDLAARNILVNS-----NLVC----KVSDFGLSRFLE----------DDT---S--DPTY--------------TSALGGKIPIRWTAPEAIQ------YRK---FTSASDVWSYGIVMWEVMSYGE--------------RP---------------YWDM-----TNQDVINAI----EQ----DYR----LPPPMDCP------------------------------SALHQ-LMLDCWQKDRNHRPK-----FGQIVNTL-------------
---V-KIEEVIGAGEFGEV---CRGRLK-------------APGKKES---CVAI-KTL---K-G--G-YT-ERQ-RR-E-FL-S----EASIMGQF--E---HPNIIRLEGVVT--N----SMP------VMILTEFMENGALDSFLR---------LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEM--------SYVHRDLAARNILVNS-----NLVC----KVSDFGLSRFLE----------ENS---S--DPTY--------------TSSLGGKIPIRWTAPEAIA------FRK---FTSASDAWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDVINAI----EQ----DYR----LPPPPDCP------------------------------TSLHQ-LMLDCWQKDRNARPR-----FPQVVSAL-------------
----IKIEEVIGTGSFGEV---RQGRLQ-------------PRGRREQ---TVAI-QAL---W-A--G-GA-ESL-QM-T-FL-G----RAAVLGQF--Q---HPNILRLEGVVT--K----SRP------LMVLTEFMELGPLDSFLR---------QR--------------------------------------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSF--------AFVHRSLSAHSVLVNS-----HLVC----KVARLGHSPQG-------------------------------------------PSCLLRWAAPEVIA------HGK---HTTSSDVWSFGILMWEVMSYGE--------------RP---------------YWDM-----SEQEVLNAI----EQ----EFR----LPPPPGCP------------------------------PGLHL-LMLDTWQKDRARRPH-----FDQLVA---AF----------
---L-KRVKVLGSGAFGTV---YKGIWVP------------EGETVKI---PVAI-KIL---N-E--T-TG-PKA-NV-E-FM-D----EALIMASM--D---HPHLVRLLGVCL-------SPT------IQLVTQLMPHGCLLEYVH---------EH--------------------------------------------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEER--------RLVHRDLAARNVLVKS-----PNHV----KITDFGLARLL-------------E---G--DEKE--------------YNADGGKMPIKWMALECIH------YRK---FTHQSDVWSYGVTIWELMTFGG--------------KP---------------YDGI-----PTREIPDLL----EK----GER----LPQPPICT------------------------------IDVYM-VMVKCWMIDADSRPK-----FKELAAE--F-----------
--VI--LGELLGKGNFGEV---YKGTLK-----------------DKT---SVAV-KTC---K-E--D-LP-QEL-KI-K-FL-Q----EAKILKQY--D---HPNIVKLIGVCT--Q----RQP------VYIIMELVSGGDFLTFLR---------RK--------------------------------------------------------------------------------------------------KDELKLKQLVKFSLDAAAGMLYLESK--------NCIHRDLAARNCLVGE-----NNVL----KISDFGMSRQE-----------------D--GGVY--------------SSSGLKQIPIKWTAPEALN------YGR---YSSESDVWSFGILLWETFSLGV--------------CP---------------YPGM-----TNQQAREQV----ER----GYR----MSAPQHCP------------------------------EDISK-IMMKCWDYKPENRPK-----FSELQKEL-------------
---L-VLGEQIGRGNFGEV---FSGRLR----------------ADNT---LVAV-KSC---R-E--T-LP-PDL-KA-K-FL-Q----EARILKQY--S---HPNIVRLIGVCT--Q----KQP------IYIVMELVQGGDFLTFLR---------TE--------------------------------------------------------------------------------------------------GARLRVKTLLQMVGDAAAGMEYLESK--------CCIHRDLAARNCLVTE-----KNVL----KISDFGMSREE-------------A---D--GVYA--------------ASGGLRQVPVKWTAPEALN------YGR---YSSESDVWSFGILLWETFSLGA--------------SP---------------YPNL-----SNQQTREFV----EK----GGR----LPCPELCP------------------------------DAVFR-LMEQCWAYEPGQRPS-----FSTIYQEL-------------
----LTLGKPLGEGCFGQV---VMAEAVGI---------DKDKPKEAV---TVAV-KML---K-D--D-AT-EKD-LS-D-LV-S----EMEMMKMIG-K---HKNIINLLGACT--Q----DGP------LYVIVEYASKGNLREYLR---------ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ--------KCIHRDLAARNVLVTE-----NNVM----KIADFGLARDI-------------N---N--IDYY--------------KKTTNGRLPVKWMAPEALF------DRV---YTHQSDVWSFGVLMWEIFTLGG--------------SP---------------YPGI-----PVEELFKLL----KE----GHR----MDKPANCT------------------------------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL-------------
----LTLGKPLGEGCFGQV---VMAEAIGI---------DKDRAAKPV---TVAV-KML---K-D--D-AT-DKD-LS-D-LV-S----EMEMMKMIG-K---HKNIINLLGACT--Q----GGP------LYVLVEYAAKGNLREFLR---------ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQ--------KCIHRDLAARNVLVTE-----DNVM----KIADFGLARDV-------------H---N--LDYY--------------KKTTNGRLPVKWMAPEALF------DRV---YTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGI-----PVEELFKLL----KE----GHR----MDKPANCT------------------------------HDLYM-IMRECWHAAPSQRPT-----FKQLVEDL-------------
---L-VLGKPLGEGCFGQV---VRAEAFGM---------DPARPDQAS---TVAV-KML---K-D--N-AS-DKD-LA-D-LV-S----EMEVMKLIG-R---HKNIINLLGVCT--Q----EGP------LYVIVECAAKGNLREFLR---------ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESR--------KCIHRDLAARNVLVTE-----DNVM----KIADFGLARGV-------------H---H--IDYY--------------KKTSNGRLPVKWMAPEALF------DRV---YTHQSDVWSFGILLWEIFTLGG--------------SP---------------YPGI-----PVEELFSLL----RE----GHR----MDRPPHCP------------------------------PELYG-LMRECWHAAPSQRPT-----FKQLVEAL-------------
----ITLERRLGTGCFGDV---WLGTWN-----------------GST---KVAV-KTL---K-P--G-TM-SP---K-A-FL-E----EAQVMKLL--R---HDKLVQLYAVVS-------EEP------IYIVTEFMCHGSLLDFLK---------NP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERM--------NYIHRDLRAANILVGE-----RLAC----KIADFGLARLI-----------------K--DDEY--------------NPCQGSKFPIKWTAPEAAL------FGR---FTIKSDVWSFGILLTELITKGR--------------IP---------------YPGM-----NKREVLEQV----EQ----GYH----MPCPPGCP------------------------------ASLYE-AMEQTWRLDPEERPT-----FEYLQSFL-------------
----LHLGRVLGYGAFGKV---VEASAFG-----------IHKGSSCD---TVAV-KML---K-E--G-AT-ASE-HR-A-LM-S----ELKILIHIG-N---HLNVVNLLGACT-KP----QGP------LMVIVEFCKYGNLSNFLR---------AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASR--------KCIHRDLAARNILLSE-----SDVV----KICDFGLARDI-------------Y---K--DPDY--------------VRKGSARLPLKWMAPESIF------DKV---YTTQSDVWSFGVLLWEIFSLGA--------------SP---------------YPGV-Q---INEEFCQRL----RD----GTR----MRAPELAT------------------------------PAIRR-IMLNCWSGDPKARPA-----FSELVEIL-------------
----IQLLKRLGSGQFGEV---WEGLWN-----------------NTT---PVAV-KTL---K-P--G-SM-DP---N-D-FL-R----EAQIMKNL--R---HPKLIQLYAVCT--L----EDP------IYIITELMRHGSLQEYLQ---------ND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESR--------NYIHRDLAARNVLVGE-----HNIY----KVADFGLARVFK-----------VD---N--EDIY--------------ESRHEIKLPVKWTAPEAIR------SNK---FSIKSDVWSFGILLYEIITYGK--------------MP---------------YSGM-----TGAQVIQML----AQ----NYR----LPQPSNCP------------------------------QQFYN-IMLECWNAEPKERPT-----FETLRWK--L-----------
----LQLIKRLGNGQFGEV---WMGTWN-----------------GNT---KVAI-KTL---K-P--G-TM-SP---E-S-FL-E----EAQIMKKL--K---HDKLVQLYAVVS-------EEP------IYIVTEYMNKGSLLDFLK---------DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERM--------NYIHRDLRSANILVGN-----GLIC----KIADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELVTKGR--------------VP---------------YPGM-----NNREVLEQV----ER----GYR----MPCPQDCP------------------------------ISLHE-LMIHCWKKDPEERPT-----FEYLQSFL-------------
----LKLEKKLGAGQFGEV---WMATYN-----------------KHT---KVAV-KTM---K-P--G-SM-SV---E-A-FL-A----EANVMKTL--Q---HDKLVKLHAVVT-------KEP------IYIITEFMAKGSLLDFLK---------SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR--------NYIHRDLRAANILVSA-----SLVC----KIADFGLARVI-----------------E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGS---FTIKSDVWSFGILLMEIVTYGR--------------IP---------------YPGM-----SNPEVIRAL----ER----GYR----MPRPENCP------------------------------EELYN-IMMRCWKNRPEERPT-----FEYIQSV--L-----------
----ITMSRELGQGSFGMV---YEGVAKG-----------VVKDEPET---RVAI-KTV---N-E--A-AS-MRE-RI-E-FL-N----EASVMKEF--N---CHHVVRLLGVVS--Q----GQP------TLVIMELMTRGDLKSYLR---------SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNAN--------KFVHRDLAARNCMVAE-----DFTV----KIGDFGMTRDI-------------Y---E--TDYY--------------RKGGKGLLPVRWMSPESLK------DGV---FTTYSDVWSFGVVLWEIATLAE--------------QP---------------YQGL-----SNEQVLRFV----ME----GGL----LDKPDNCP------------------------------DMLFE-LMRMCWQYNPKMRPS-----FLEIISS--I-----------
----ITLLRELGQGSFGMV---YEGNARD-----------IIKGEAET---RVAV-KTV---N-E--S-AS-LRE-RI-E-FL-N----EASVMKGF--T---CHHVVRLLGVVS--K----GQP------TLVVMELMAHGDLKSYLR---------SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK--------KFVHRDLAARNCMVAH-----DFTV----KIGDFGMTRDI-------------Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK------DGV---FTTSSDMWSFGVVLWEITSLAE--------------QP---------------YQGL-----SNEQVLKFV----MD----GGY----LDQPDNCP------------------------------ERVTD-LMRMCWQFNPKMRPT-----FLEIVNLL-------------
---I-SIIRELGQGSFGMV---YEGLARG-----------LEAGEEST---PVAL-KTV---N-E--L-AS-PRE-CI-E-FL-K----EASVMKAF--K---CHHVVRLLGVVS--Q----GQP------TLVIMELMTRGDLKSHLR---------SLRPEA-----------------------------------------------------------------------------------------ENNPGLPQPALGEMIQMAGEIADGMAYLAAN--------KFVHRDLAARNCMVSQ-----DFTV----KIGDFGMTRDV-------------Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK------DGI---FTTHSDVWSFGVVLWEIVTLAE--------------QP---------------YQGL-----SNEQVLKFV----MD----GGV----LEELEGCP------------------------------LQLQE-LMSRCWQPNPRLRPS-----FTHILD---SI----------
-VGG----NKMGEGGFGVV---YKGYVN----------------NTT-----VAV-KKL---AAM--V-DITTE---ELK-QQFD---QEIKVMAKC--Q---HENLVELLGFSS--D----GDD------LCLVYVYMPNGSLLDRLSC-----LDGTP----------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN--------HHIHRDIKSANILLDE-----AFTA----KISDFGLARASE---------------KFAQTVMT--------------SR---IVGTTAYMAPEALR-------GE---ITPKSDIYSFGVVLLEIIT-GL--------------PA---------------VDEH-----REPQLLLDI----KE----EIE----DEEKTIEDYIDKKMNDAD----------------STSVEAMYS-VASQCLHEKKNKRPD-----IKKVQQ----LLQ--------
----LTFVQEIGSGQFGLV---HLGYWL-----------------NKD---KVAI-KTI---R-E--G-AM-SE---E-D-FI-E----EAEVMMKL--S---HPKLVQLYGVCL--E----QAP------ICLVFEFMEHGCLSDYLR---------TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEA--------CVIHRDLAARNCLVGE-----NQVI----KVSDFGMTRFV-----------------L--DDQY--------------TSSTGTKFPVKWASPEVFS------FSR---YSSKSDVWSFGVLMWEVFSEGK--------------IP---------------YENR-----SNSEVVEDI----ST----GFR----LYKPRLAS------------------------------THVYQ-IMNHCWKERPEDRPA-----FSRLLRQL-------------
---L-KRIRDLGEGHFGKV---ELCRYDP------------EGDNTGE---QVAV-KSL---K-P--E-SG-GNH-IA-D-LK-K----EIEILRNL--Y---HENIVKYKGICT-ED-----GGN----GIKLIMEFLPSGSLKEYLP---------KN--------------------------------------------------------------------------------------------------KNKINLKQQLKYAVQICKGMDYLGSR--------QYVHRDLAARNVLVES-----EHQV----KIGDFGLTKAI------------ET---D--KEYY--------------TVKDDRDSPVFWYAPECLM------QSK---FYIASDVWSFGVTLHELLTYCD--------------SDSSPMALF-LKMIGPTHGQM-----TVTRLVNTL----KE----GKR----LPCPPNCP------------------------------DEVYQ-LMRKCWEFQPSNRTS-----FQNLIE---GF----------
----LKFLQQLGKGNFGSV---EMCRYDP------------LQDNTGE---VVAV-KKL---Q-H--S-TE--EH-LR-D-FE-R----EIEILKSL--Q---HDNIVKYKGVCYSAG----RRN------LKLIMEYLPYGSLRDYLQ---------KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK--------RYIHRDLATRNILVEN-----ENRV----KIGDFGLTKVL------------PQ---D--KEYY--------------KVKEPGESPIFWYAPESLT------ESK---FSVASDVWSFGVVLYELFTYIE--------------KSKSPPAEFMRMIGNDKQGQM-----IVFHLIELL----KN----NGR----LPRPDGCP------------------------------DEIYM-IMTECWNNNVNQRPS-----FRDLA----LRV---------
---L-KYISQLGKGNFGSV---ELCRYDP------------LGDNTGA---LVAV-KQL---Q-H--S-GP-DQ--QR-D-FQ-R----EIQILKAL--H---SDFIVKYRGVSYGPG----RQS------LRLVMEYLPSGCLRDFLQ---------RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSR--------RCVHRDLAARNILVES-----EAHV----KIADFGLAKLL------------PL---D--KDYY--------------VVREPGQSPIFWYAPESLS------DNI---FSRQSDVWSFGVVLYELFTYCD--------------KSCSPSAE--FLRMMGCERDV-P---ALCRLLELL----EE----GQR----LPAPPACP------------------------------AEVHE-LMKLCWAPSPQDRPS-----FSALGP---QL----------
----LKLGKPLGRGAFGQV---IEADAFG-----------IDKTATCR---TVAV-KML---K-E--G-AT-HSE-HR-A-LM-S----ELKILIHIG-H---HLNVVNLLGACT-KP----GGP------LMVIVEFCKFGNLSTYLR---------SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASR--------KCIHRDLAARNILLSE-----KNVV----KICDFGLARDI-------------Y---K--DPDY--------------VRKGDARLPLKWMAPETIF------DRV---YTIQSDVWSFGVLLWEIFSLGA--------------SP---------------YPGV-K---IDEEFCRRL----KE----GTR----MRAPDYTT------------------------------PEMYQ-TMLDCWHGEPSQRPT-----FSELVEHL-------------
----LSFGKTLGAGAFGKV---VEATAYG-----------LIKSDAAM---TVAV-KML---K-P--S-AH-LTE-RE-A-LM-S----ELKVLSYLG-N---HMNIVNLLGACT--I----GGP------TLVITEYCCYGDLLNFLR---------RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK--------NCIHRDLAARNILLTH-----GRIT----KICDFGLARDI-------------K---N--DSNY--------------VVKGNARLPVKWMAPESIF------NCV---YTFESDVWSYGIFLWELFSLGS--------------SP---------------YPGM-P---VDSKFYKMI----KE----GFR----MLSPEHAP------------------------------AEMYD-IMKTCWDADPLKRPT-----FKQIVQL--I-----------
----LKLVERLGAGQFGEV---WMGYYN-----------------GHT---KVAV-KSL---K-Q--G-SM-SP---D-A-FL-A----EANLMKQL--Q---HQRLVRLYAVVT-------QEP------IYIITEYMENGSLVDFLK---------TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVSD-----TLSC----KIADFGLARLI-----------------E--DNEY--------------TAREGAKFPIKWTAPEAIN------YGT---FTIKSDVWSFGILLTEIVTHGR--------------IP---------------YPGM-----TNPEVIQNL----ER----GYR----MVRPDNCP------------------------------EELYQ-LMRLCWKERPEDRPT-----FDYLRSV--L-----------
--LI--HGEVLGKGCFGQA---IKVTHR----------------ETGE---VMVM-KEL---I----R-FD-EET-QR-T-FL-K----EVKVMRCL--E---HPNVLKFIGVLY--K----DKR------LNFITEYIKGGTLRGIIK---------SM--------------------------------------------------------------------------------------------------DSQYPWSQRVSFAKDIASGMAYLHSM--------NIIHRDLNSHNCLVRE-----NKNV----VVADFGLARLM-------------V---D--EKTQPEGLRS--LKKPDRKKRYTVVGNPYWMAPEMIN------GRS---YDEKVDVFSFGIVLCEIIGRVN--------------AD---------------PDYL-P---RTMDFGLNV----RG----FLD----RYCPPNCP------------------------------PSFFP-ITVRCCDLDPEKRPS-----FVKLEH---WL----------
--LI--HGEVLGKGFFGQA---IKVTHK-----------------ATG---KVMVMKEL-----I--R-CD-EET-QK-T-FL-T----EVKVMRSL--D---HPNVLKFIGVLY--K----DKK------LNLLTEYIEGGTLKDFLR---------SM---------------------------------------------------------------------------------------------------DPFPWQQKVRFAKGIASGMAYLHSM--------CIIHRDLNSHNCLIKL-----DKTV----VVADFGLSRLIVEERKRAPMEKATT---------KKRTL-----RKNDRKKRYTVVGNPYWMAPEMLN------GKS---YDETVDIFSFGIVLCEIIGQVY--------------AD---------------PDCL-P---RTLDFGLNV----KL----FWE----KFVPTDCP------------------------------PAFFP-LAAICCRLEPESRPA-----FSKLED---SF----------
---V-TLLRALGHGAFGEV---YEGLVIG-----------LPGDSSPL---QVAI-KTL---P-E--L-CS-PQD-EL-D-FL-M----EALIISKF--R---HQNIVRCVGLSL--R----ATP------RLILLELMSGGDMKSFLR---------HSRP--------------------------------------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEEN--------HFIHRDIAARNCLLSCA--GPSRVA----KIGDFGMARDI-------------Y---R--ASYY--------------RRGDRALLPVKWMPPEAFL------EGI---FTSKTDSWSFGVLLWEIFSLGY--------------MP---------------YPGR-----TNQEVLDFV----VG----GGR----MDPPRGCP------------------------------GPVYR-IMTQCWQHEPELRPS-----FASILERL-------------
----IKLVKRLGAGQFGEV---WMGYYN-----------------NST---KVAV-KTL---K-P--G-TM-SV---Q-A-FL-E----EANLMKTL--Q---HDKLVRLYAVVT--R----EEP------IYIITEYMAKGSLLDFLK---------SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERK--------NYIHRDLRAANVLVSE-----SLMC----KIADFGLARVI-----------------E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGC---FTIKSDVWSFGILLYEIVTYGK--------------IP---------------YPGR-----TNADVMTAL----SQ----GYR----MPRVENCP------------------------------DELYD-IMKMCWKEKAEERPT-----FDYLQSV--L-----------
---L-ILGKILGEGEFGSV---MEGNLK-------------QEDGTSL---KVAV-KTM---KLD--N-SS-QRE-IE-E-FL-S----EAACMKDF--S---HPNVIRLLGVCI--E----MSSQG-IPKPMVILPFMKYGDLHTYLL---------YSRL---------------------------------------------------------------------------------------------ETGPKHIPLQTLLKFMVDIALGMEYLSNR--------NFLHRDLAARNCMLRD-----DMTV----CVADFGLSKKI-------------Y---S--GDYY--------------RQGRIAKMPVKWIAIESLA------DRV---YTSKSDVWAFGVTMWEIATRGM--------------TP---------------YPGV-----QNHEMYDYL----LH----GHR----LKQPEDCL------------------------------DELYE-IMYSCWRTDPLDRPT-----FSVLRLQ--L-----------
----VHFNEVIGRGHFGCV---YHGTLL-------------DNDGKKI---HCAV-KSL---N-R--I-TD-IGE-VS-Q-FL-T----EGIIMKDF--S---HPNVLSLLGICL-RS----EGS------PLVVLPYMKHGDLRNFIR---------NE--------------------------------------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASK--------KFVHRDLAARNCMLDE-----KFTV----KVADFGLARDM-------------Y---D--KEYYS------------VHNKTGAKLPVKWMALESLQ------TQK---FTTKSDVWSFGVLLWELMTRGA--------------PP---------------YPDV-----NTFDITVYL----LQ----GRR----LLQPEYCP------------------------------DPLYE-VMLKCWHPKAEMRPS-----FSELVSR--I-----------
---I-EYVRDIGEGAFGRV---FQARAPG-----------LLPYEPFT---MVAV-KML---K-E--E-AS-ADM-QA-D-FQ-R----EAALMAEF--D---NPNIVKLLGVCA--V----GKP------MCLLFEYMAYGDLNEFLR---------SMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSER--------KFVHRDLATRNCLVGE-----NMVV----KIADFGLSRNI-------------Y---S--ADYY--------------KANENDAIPIRWMPPESIF------YNR---YTTESDVWAYGVVLWEIFSYGL--------------QP---------------YYGM-----AHEEVIYYV----RD----GNI----LSCPENCP------------------------------VELYN-LMRLCWSKLPADRPS-----FTSIHRIL-------------
---Y-VRLQKIGEGSFGKA---ILVKST----------------EDGR---QYVI-KEI---NIS--R-MSSKE---R-E-ESRR----EVAVLANM--K---HPNIVQYRESFE--E----NGS------LYIVMDYCEGGDLFKRINA------QKGV----------------------------------------------------------------------------------------------------LFQEDQILDWFVQICLALKHVHDR--------KILHRDIKSQNIFLTK-----DGTV----QLGDFGIARVL-----------------NSTVELA--------------RT---CIGTPYYLSPEICE------NKP---YNNKSDIWALGCVLYELCT-LK--------------HA---------------FEAG--------SMKNLV----LK----IIS----GSFPPVSLHYS---------------------------YDLRS-LVSQLFKRNPRDRPS-----VNSILEKGF-I----------
----YEVLYTIGTGSYGRC---QKIRRK----------------SDGK---ILVW-KEL---DYG--S-MTEAE---K-Q-MLVS----EVNLLREL--K---HPNIVRYYDRII--DR--TNTT------LYIVMEYCEGGDLASVITKG----TKERQ----------------------------------------------------------------------------------------------------YLDEEFVLRVMTQLTLALKECHRRSD---GGHTVLHRDLKPANVFLDG-----KQNV----KLGDFGLARIL-----------------NHDTSFA--------------KT---FVGTPYYMSPEQMN------RMS---YNEKSDIWSLGCLLYELCA-LM--------------PP---------------FTAF--------SQKELA----GK----IRE----GKFRRIPYRY---S------------------------DELNE-IITRMLNLKDYHRPS-----VEEILENPL-I----------
---Y-MVLRMIGEGSFGRA---LLVQHE----------------SSNQ---MFAM-KEI---RLP--K-SFSNT---Q-N--SRK----EAVLLAKM--K---HPNIVAFKESFE--A----EGH------LYIVMEYCDGGDLMQKIKQ------QKGK----------------------------------------------------------------------------------------------------LFPEDMILNWFTQMCLGVNHIHKK--------RVLHRDIKSKNIFLTQ-----NGKV----KLGDFGSARLL-----------------SNPMAFA--------------CT---YVGTPYYVPPEIWE------NLP---YNNKSDIWSLGCILYELCT-LK--------------HP---------------FQAN-----SWKNLILKV----CQ----GCI----SPLPSHYS------------------------------YELQF-LVKQMFKRNPSHRPS-----ATTLLS----RGIV-------
---Y-CYLRVVGKGSYGEV---TLVKHR----------------RDGK---QYVI-KKL---NLR--N-ASSRE---R-R-AAEQ----EAQLLSQL--K---HPNIVTYKESWE--G---GDGL------LYIVMGFCEGGDLYRKLKE------QKGQ----------------------------------------------------------------------------------------------------LLPENQVVEWFVQIAMALQYLHEK--------HILHRDLKTQNVFLTR-----TNII----KVGDLGIARVL-----------------ENHCDMA--------------ST---LIGTPYYMSPELFS------NKP---YNYKSDVWALGCCVYEMAT-LK--------------HA---------------FNAK--------DMNSLV----YR----IIE----GKLPPMPRDY---S------------------------PELAE-LIRTMLSKRPEERPS-----VRSILRQPYI-----------
----YDVIKAIGQGAFGKA---YLAKGK----------------SDSK---HCVI-KEI---NFE--K-MPIQE---K-E-ASKK----EVILLEKM--K---HPNIVAFFNSFQ--E----NGR------LFIVMEYCDGGDLMKRINR------QRGV----------------------------------------------------------------------------------------------------LFSEDQILGWFVQISLGLKHIHDR--------KILHRDIKAQNIFLSK-----NGMV---AKLGDFGIARVL-----------------NNSMELA--------------RT---CIGTPYYLSPEICQ------NKP---YNNKTDIWSLGCVLYELCT-LK--------------HP---------------FEGN--------NLQQLV----LK----ICQ----AHFAPISPGF---S------------------------RELHS-LISQLFQVSPRDRPS-----INSILKRPFL-----------
-YIP---IRVLGRGAFGEA---TLYRRT----------------EDDS---LVVW-KEV---DLT--R-LSEKE---R-R-DALN----EIVILALL--Q---HDNIIAYYNHFM--D----NTT------LLIELEYCNGGNLYDKILR------QKDK----------------------------------------------------------------------------------------------------LFEEEMVVWYLFQIVSAVSCIHKA--------GILHRDIKTLNIFLTK-----ANLI----KLGDYGLAKKL-----------------NSEYSMA--------------ET---LVGTPYYMSPELCQ------GVK---YNFKSDIWAVGCVIFELLT-LK--------------RT---------------FDAT--------NPLNLC----VK----IVQ----GIRAMEVDSS-QYS------------------------LELIQ-MVHSCLDQDPEQRPT-----ADELLDRPL-L----------
--IV--LKWELGEGAFGKV---FLAECHN-----------LLPEQDKM---LVAV-KAL---K-E--A-SE-SA--RQ-D-FQ-R----EAELLTML--Q---HQHIVRFFGVCT--E----GRP------LLMVFEYMRHGDLNRFLR---------SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGL--------HFVHRDLATRNCLVGQ-----GLVV----KIGDFGMSRDI-------------Y---S--TDYY--------------RVGGRTMLPIRWMPPESIL------YRK---FTTESDVWSFGVVLWEIFTYGK--------------QP---------------WYQL-----SNTEAIDCI----TQ----GRE----LERPRACP------------------------------PEVYA-IMRGCWQREPQQRHS-----IKDVHARL-------------
---I-VLKRELGEGAFGKV---FLAECYN-----------LCPEQDKI---LVAV-KTL---K-D--A-SD-NA--RK-D-FH-R----EAELLTNL--Q---HEHIVKFYGVCV--E----GDP------LIMVFEYMKHGDLNKFLR---------AHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQ--------HFVHRDLATRNCLVGE-----NLLV----KIGDFGMSRDV-------------Y---S--TDYY--------------RVGGHTMLPIRWMPPESIM------YRK---FTTESDVWSLGVVLWEIFTYGK--------------QP---------------WYQL-----SNNEVIECI----TQ----GRV----LQRPRTCP------------------------------QEVYE-LMLGCWQREPHMRKN-----IKGIHTL--L-----------
---I-VLKRELGEGAFGKV---FLAECYN-----------LSPTKDKM---LVAV-KAL---K-D--P-TL-AA--RK-D-FQ-R----EAELLTNL--Q---HEHIVKFYGVCG--D----GDP------LIMVFEYMKHGDLNKFLR---------AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQ--------HFVHRDLATRNCLVGA-----NLLV----KIGDFGMSRDV-------------Y---S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM------YRK---FTTESDVWSFGVILWEIFTYGK--------------QP---------------WFQL-----SNTEVIECI----TQ----GRV----LERPRVCP------------------------------KEVYD-VMLGCWQREPQQRLN-----IKEIYKIL-------------
----YELQEVIGSGATAVV---QAAYCA----------------PKKE---KVAI-KRI---NLE--K-CQTSM---D-E--LLK----EIQAMSQC--H---HPNIVSYYTSFV--V----KDE------LWLVMKLLSGGSVLDIIKHIVAKGEHKSG----------------------------------------------------------------------------------------------------VLDESTIATILREVLEGLEYLHKN--------GQIHRDVKAGNILLGE-----DGSV----QIADFGVSAFLAT------------GGDITRNKVR--------------KT---FVGTPCWMAPEVME-----QVRG---YDFKADIWSFGITAIELAT-GA--------------AP---------------YHKY-----PPMKVLMLT----LQ----NDP----PSLETGVQDKE--MLK-------------------KYGKSFRK-MISLCLQKDPEKRPT-----AAELLRHKFF-----------
DNFI-----KIGEGSTGIV---CIATVR----------------SSGK---LVAV-KKM---DLR--K-QQRRE---L----LFN----EVVIMRDY--Q---HENVVEMYNSYL--V----GDE------LWVVMEFLEGGALTDIVT---------HT----------------------------------------------------------------------------------------------------RMNEEQIAAVCLAVLQALSVLHAQ--------GVIHRDIKSDSILLTH-----DGRV----KLSDFGFCAQV-----------------SKEVPRR--------------KS---LVGTPYWMAPELIS------RLP---YGPEVDIWSLGIMVIEMVD-GE--------------PP---------------YFNE-----PPLKAMKMI----RD----NLP----PRLKNLHKVS----------------------------PSLKG-FLDRLLVRDPAQRAT-----AAELLKHPFL-----------
---L-VLGRVLGSGAFGKV---VEGTAYG-----------LSRSQPVM---KVAV-KML---K-P--T-AR-SSE-KQ-A-LM-S----ELKIMTHLG-P---HLNIVNLLGACT--K----SGP------IYIITEYCFYGDLVNYLH---------KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASK--------NCVHRDLAARNVLLAQ-----GKIV----KICDFGLARDI-------------M---H--DSNY--------------VSKGSTFLPVKWMAPESIF------DNL---YTTLSDVWSYGILLWEIFSLGG--------------TP---------------YPGM-M---VDSTFYNKI----KS----GYR----MAKPDHAT------------------------------SEVYE-IMVKCWNSEPEKRPS-----FYHLSE---IV----------
---L-VLGRTLGSGAFGQV---VEATAHG-----------LSHSQATM---KVAV-KML---K-S--T-AR-SSE-KQ-A-LM-S----ELKIMSHLG-P---HLNVVNLLGACT--K----GGP------IYIITEYCRYGDLVDYLH---------RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASK--------NCVHRDLAARNVLICE-----GKLV----KICDFGLARDI-------------M---R--DSNY--------------ISKGSTFLPLKWMAPESIF------NSL---YTTLSDVWSFGILLWEIFTLGG--------------TP---------------YPEL-P---MNEQFYNAI----KR----GYR----MAQPAHAS------------------------------DEIYE-IMQKCWEEKFEIRPP-----FSQLVL---LL----------
---F-KFGKILGEGSFSTV---VLAREL----------------ATSR---EYAI-KIL---EKR--H-IIKEN---K-VPYVTR----ERDVMSRL--D---HPFFVKLYFTFQ--D----DEK------LYFGLSYAKNGELLKYIR--------KIG----------------------------------------------------------------------------------------------------SFDETCTRFYTAEIVSALEYLHGK--------GIIHRDLKPENILLNE-----DMHI----QITDFGTAKVLS---------------PESKQARA--------------NS---FVGTAQYVSPELLT------EKS---ACKSSDLWALGCIIYQLVA-GL--------------PP---------------FRAG--------NEYLIF----QK----IIK----LEYDFPEKFF----------------------------PKARD-LVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
---F-KFLAVLGRGHFGKV---LLSEFR----------------PSGE---LFAI-KAL---KKG--D-IVARD---E-V-ESLM---CEKRILAAV--TSAGHPFLVNLFGCFQ--T----PEH------VCFVMEYSAGGDLMLHIH---------SD----------------------------------------------------------------------------------------------------VFSEPRAIFYSACVVLGLQFLHEH--------KIVYRDLKLDNLLLDT-----EGYV----KIADFGLCKEG-----------------MGYGDRT--------------ST---FCGTPEFLAPEVLT------DTS---YTRAVDWWGLGVLLYEMLV-GE--------------SP---------------FPGD--------DEEEVF----DS----IVN----DEVRYPRFLS----------------------------AEAIG-IMRRLLRRNPERRLGSSERDAEDVKKQPFF-----------
-FAD----EVLGSGQFGIV---YGGKHR----------------KTGR---DVAI-KVI---DKM--R-FPTKQ---E-S-QLRN----EVAILQNL--H---HPGIVNLECMFE--T----PER------VFVVMEKLHGDMLEMILS-------SEKS----------------------------------------------------------------------------------------------------RLPERITKFMVTQILVALRNLHFK--------NIVHCDLKPENVLLAS-----AEPFP-QVKLCDFGFARI------------------IGEKSFR--------------RS---VVGTPAYLAPEVLR------SKG---YNRSLDMWSVGVIIYVSLS-GT--------------FP---------------FNED----------EDIN----DQ----IQN----AAFMYPPNPWREIS------------------------GEAID-LINNLLQVKMRKRYS-----VDKSLSHPWL-----------
---F-TLCRKLGSGYFGEV---FEGLWK-----------------DRV---QVAI-KVI---S-R--D-NL-LH--QQ-M-LQ-S----EIQAMKKL--R---HKHILALYAVVS--V----GDP------VYIITELMAKGSLLELLR---------DS-------------------------------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQ--------NYIHRDLAARNILVGE-----NTLC----KVGDFGLARLI--------------------KEDV--------------YLSHDHNIPYKWTAPEALS------RGH---YSTKSDVWSFGILLHEMFSRGQ--------------VP---------------YPGM-----SNHEAFLRV----DA----GYR----MPCPLECP------------------------------PSVHK-LMLTCWCRDPEQRPC-----FKALRERL-------------
---L-VLGKTLGEGEFGKV---VKATAFH-----------LKGRAGYT---TVAV-KML---K-E--N-AS-PSE-LR-D-LL-S----EFNVLKQV--N---HPHVIKLYGACS--Q----DGP------LLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM--------KLVHRDLAARNILVAE-----GRKM----KISDFGLSRDV-------------Y---E--EDSY--------------VKRSQGRIPVKWMAIESLF------DHI---YTTQSDVWSFGVLLWEIVTLGG--------------NP---------------YPGI-----PPERLFNLL----KT----GHR----MERPDNCS------------------------------EEMYR-LMLQCWKQEPDKRPV-----FADISKDL-------------
--LT--LRLLLGSGAFGEV---YEGTAVDI----------LGVGSGEI---KVAV-KTL---K-K--G-ST-DQE-KI-E-FL-K----EAHLMSKF--N---HPNILKQLGVCL--L----NEP------QYIILELMEGGDLLTYLR---------KARM--------------------------------------------------------------------------------------------ATFYGPLLTLVDLVDLCVDISKGCVYLERM--------HFIHRDLAARNCLVSVKDYTSPRIV----KIGDFGLARDI-------------Y---K--NDYY--------------RKRGEGLLPVRWMAPESLM------DGI---FTTQSDVWSFGILIWEILTLGH--------------QP---------------YPAH-----SNLDVLNYV----QT----GGR----LEPPRNCP------------------------------DDLWN-LMTQCWAQEPDQRPT-----FHRIQDQL-------------
----FELLKVLGQGSFGKVFLVRKVTRP----------------DSGH---LYAM-KVL---KKA--T-LKVRD---R-V-RTKM----ERDILADV--N---HPFVVKLHYAFQ--T----EGK------LYLILDFLRGGDLFTRLS--------KEV----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALGLDHLHSL--------GIIYRDLKPENILLDE-----EGHI----KLTDFGLSKEA-----------------IDHEKKA--------------YS---FCGTVEYMAPEVVN------RQG---HSHSADWWSYGVLMFEMLT-GS--------------LP---------------FQGK--------DRKETM----TL----ILK----AKLGMPQFLS----------------------------TEAQS-LLRALFKRNPANRLGSGPDGAEEIKRHV--FY---------
----FELLKVLGQGSFGKV---FLVKKI----------------SGSDARQLYAM-KVL---KKA--T-LKVRD---R-V-RTKM----ERDILVEV--N---HPFIVKLHYAFQ--T----EGK------LYLILDFLRGGDLFTRLS--------KEV----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHSL--------GIIYRDLKPENILLDE-----EGHI----KLTDFGLSKES-----------------IDHEKKA--------------YS---FCGTVEYMAPEVVN------RRG---HTQSADWWSFGVLMFEMLT-GT--------------LP---------------FQGK--------DRKETM----TM----ILK----AKLGMPQFLS----------------------------PEAQS-LLRMLFKRNPANRLGAGPDGVEEIKRHSFF-----------
----WEIIGELGDGAFGKV---YKAQNK----------------ETSV---LAAA-KVI---DTK--S-EEELE---D-Y-M--V----EIDILASC--D---HPNIVKLLDAFY--Y----ENN------LWILIEFCAGGAVDAVML-------ELER----------------------------------------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHDN--------KIIHRDLKAGNILFTL-----DGDI----KLADFGVSAKN-----------------TRTIQRR--------------DS---FIGTPYWMAPEVVMCE-TSKDRP---YDYKADVWSLGITLIEMAE-IE--------------PP---------------HHEL-----NPMRVLLKI----AK----SEP----PTLAQPSRWS----------------------------SNFKD-FLKKCLEKNVDARWT-----TSQLLQHPFV-----------
---L-RLEVKLGQGCFGEV---WMGTWN-----------------GTT---RVAI-KTL---K-P--G-TM-SP---E-A-FL-Q----EAQVMKKL--R---HEKLVQLYAVVS-------EEP------IYIVTEYMSKGSLLDFLK---------GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVGE-----NLVC----KVADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELTTKGR--------------VP---------------YPGM-----VNREVLDQV----ER----GYR----MPCPPECP------------------------------ESLHD-LMCQCWRKEPEERPT-----FEYLQAF--L-----------
--FA--LGRKLGEGYFGEV---WEGLWL-----------------GSL---PVAI-KVI---K-S--A-NM-K---LT-D-LA-K----EIQTLKGL--R---HERLIRLHAVCS--G----GEP------VYIVTELMRKGNLQAFLG---------TP-------------------------------------------------------------------------------------------------EGRALRLPPLLGFACQVAEGMSYLEEQ--------RVVHRDLAARNVLVDD-----GLAC----KVADFGLARLL-----------------K--DDIY--------------SPSSSSKIPVKWTAPEAAN------YRV---FSQKSDVWSFGVLLHEVFTYGQ--------------CP---------------YEGM-----TNHETLQQI----MR----GYR----LPRPAACP------------------------------AEVYV-LMLECWRSSPEERPS-----FATLREKL-------------
----WEIVGELGDGAFGKV---YKAKNK----------------ETGA---LAAA-KVI---ETK--S-EEELE---D-Y-I--V----EIEILATC--D---HPYIVKLLGAYY--H----DGK------LWIMIEFCPGGAVDAIML-------ELDR----------------------------------------------------------------------------------------------------GLTEPQIQVVCRQMLEALNFLHSK--------RIIHRDLKAGNVLMTL-----EGDI----RLADFGVSAKN-----------------LKTLQKR--------------DS---FIGTPYWMAPEVVMCE-TMKDTP---YDYKADIWSLGITLIEMAQ-IE--------------PP---------------HHEL-----NPMRVLLKI----AK----SDP----PTLLTPSKWS----------------------------VEFRD-FLKIALDKNPETRPS-----AAQLLEHPFV-----------
-ILT---SKELGRGKFAVV---RQCISK----------------STGQ---EYAA-KFL---KKR--R-RGQDC---R-A-EILH----EIAVLELA-KS---CPRVINLHEVYE--N----TSE------IILILEYAAGGEIFSLCLP------ELAE----------------------------------------------------------------------------------------------------MVSENDVIRLIKQILEGVYYLHQN--------NIVHLDLKPQNILLSS-----IYPLG-DIKIVDFGMSRK------------------IGHACEL--------------RE---IMGTPEYLAPEILN------YDP---ITTATDMWNIGIIAYMLLT-HT--------------SP---------------FVGE--------DNQETY----LN----ISQ----VNVDYSEETFSSVS------------------------QLATD-FIQSLLVKNPEKRPT-----AEICLSHSWL-----------
----YHVLEMIGEGSFGRV---YKGRRK----------------YSAQ---VVAL-KFI---PKL--G-RSEKE---L-R-NLQR----EIEIMRGL--R---HPNIVHMLDSFE--T----DKE------VVVVTDYAEG-ELFQILE--------DDG----------------------------------------------------------------------------------------------------KLPEDQVQAIAAQLVSALYYLHSH--------RILHRDMKPQNILLAK-----GGGI----KLCDFGFARAM-----------------STNTMVL--------------TS---IKGTPLYMSPELVE------ERP---YDHTADLWSVGCILYELAV-GT--------------PP---------------FYAT--------SIFQLV----SL----ILK----DPVRWPSTIS----------------------------PCFKN-FLQGLLTKDPRQRLS-----WPDLLYHPFI-----------
-TLE---DKELGSGNFGTV---KKGYYQ--------------MKKVVK---TVAV-KIL---K-N--E-AN-DPALKD-E-LL-A----EANVMQQL--D---NPYIVRMIGICE-------AES------WMLVMEMAELGPLNKYLQ---------QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEES--------NFVHRDLAARNVLLVT-----QHYA----KISDFGLSKAL-------------R---A--DENY-------------YKAQTHGKWPVKWYAPECIN------YYK---FSSKSDVWSFGVLMWEAFSYGQ--------------KP---------------YRGM-----KGSEVTAML----EK----GER----MGCPAGCP------------------------------REMYD-LMNLCWTYDVENRPG-----FAAVE----LRL---------
----LTFMRELGSGLFGVV---RLGKWR-----------------AQY---KVAI-KAI---R-E--G-AM-CE---E-D-FI-E----EAKVMMKL--T---HPKLVQLYGVCT--Q----QKP------IYIVTEFMERGCLLNFLR---------QR--------------------------------------------------------------------------------------------------QGHFSRDVLLSMCQDVCEGMEYLERN--------SFIHRDLAARNCLVSE-----AGVV----KVSDFGMARYV-----------------L--DDQY--------------TSSSGAKFPVKWCPPEVFN------YSR---FSSKSDVWSFGVLMWEVFTEGR--------------MP---------------FEKY-----TNYEVVTMV----TR----GHR----LYQPKLAS------------------------------NYVYE-VMLRCWQEKPEGRPS-----FEDLLRT--I-----------
-VCR---GELLGSGCFGVV---HRGLWT-------------LPSGKSV---PVAV-KSLRVGP-E--G-PM-GTE-LG-D-FL-R----EVSVMMNL--E---HPHVLRLHGLVL-------GQP------LQMVMELAPLGSLHARLT---------AP------------------------------------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGAR--------GLVHRDLATRNLLLAS-----PRTI----KVADFGLVRPL------------GG---A--RGRY--------------VMGGPRPIPYAWCAPESLR------HGA---FSSASDVWMFGVTLWEMFSGGE--------------EP---------------WAGV-----PPYLILQRL----ED----RAR----LPRPPLCS------------------------------RALYS-LALRCWAPHPADRPS-----FSHLE----GLL---------
---L-RLLEKLGDGSFGVV---RRGEWD-------------APSGKTV---SVAV-KCL---K-PDVL-SQ-PEA-MD-D-FI-R----EVNAMHSL--D---HRNLIRLYGVVL-------TPP------MKMVTELAPLGSLLDRLR---------KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK--------RFIHRDLAARNLLLAT-----RDLV----KIGDFGLMRAL------------PQ---N--DDHY--------------VMQEHRKVPFAWCAPESLK------TRT---FSHASDTWMFGVTLWEMFTYGQ--------------EP---------------WIGL-----NGSQILHKI---DKE----GER----LPRPEDCP------------------------------QDIYN-VMVQCWAHKPEDRPT-----FVALRDF--L-----------
---L-AFIKEIGSGQFGVV---HLGEWR-----------------SHI---QVAI-KAI---N-E--G-SM-SE---E-D-FI-E----EAKVMMKL--S---HSKLVQLYGVCI--Q----RKP------LYIVTEFMENGCLLNYLR---------EN--------------------------------------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLERN--------GYIHRDLAARNCLVSS-----TCIV----KISDFGMTRYV-----------------L--DDEY--------------VSSFGAKFPIKWSPPEVFL------FNK---YSSKSDVWSFGVLMWEVFTEGK--------------MP---------------FENK-----SNLQVVEAI----SE----GFR----LYRPHLAP------------------------------MSIYE-VMYSCWHEKPEGRPT-----FAELLR---AV----------
---L-KKIRDLGEGHFGKV---SLYCYDP------------TNDGTGE---MVAV-KAL---K-A--D-CG-PQH-RS-G-WK-Q----EIDILRTL--Y---HEHIIKYKGCCEDQG----EKS------LQLVMEYVPLGSLRDYLP---------RH----------------------------------------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHAQ--------HYIHRDLAARNVLLDN-----DRLV----KIGDFGLAKAV------------PE---G--HEYY--------------RVREDGDSPVFWYAPECLK------EYK---FYYASDVWSFGVTLYELLTHCD--------------SSQSPPTKF-LELIGIAQGQM-----TVLRLTELL----ER----GER----LPRPDKCP------------------------------CEVYH-LMKNCWETEASFRPT-----FENLIP---IL----------
---F-TLGRMLGKGEFGSV---REAQLK-------------QEDGSFV---KVAV-KML---K-A-DI-IA-SSD-IE-E-FL-R----EAACMKEF--D---HPHVAKLVGVSL--R----SRAKGRLPIPMVILPFMKHGDLHAFLL---------ASRI---------------------------------------------------------------------------------------------GENPFNLPLQTLIRFMVDIACGMEYLSSR--------NFIHRDLAARNCMLAE-----DMTV----CVADFGLSRKI-------------Y---S--GDYY--------------RQGCASKLPVKWLALESLA------DNL---YTVQSDVWAFGVTMWEIMTRGQ--------------TP---------------YAGI-----ENAEIYNYL----IG----GNR----LKQPPECM------------------------------EDVYD-LMYQCWSADPKQRPS-----FTCLRME--L-----------
---L-RLEVKLGQGCFGEV---WMGTWN-----------------GTT---KVAI-KTL---K-P--G-TM-MP---E-A-FL-Q----EAQIMKKL--R---HDKLVPLYAVVS-------EEP------IYIVTEFMSKGSLLDFLK---------EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERM--------NYIHRDLRAANILVGE-----NLVC----KIADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILQTELVTKGR--------------VP---------------YPGM-----VNREVLEQV----ER----GYR----MPCPQGCP------------------------------ESLHE-LMNLCWKKDPDERPT-----FEYIQSFL-------------
LIAD----IELGCGNFGSV---RQGVYR--------------MRKKQI---DVAI-KVL---K-Q--G-TE-KAD-TE-E-MM-R----EAQIMHQL--D---NPYIVRLIGVCQ-------AEA------LMLVMEMAGGGPLHKFLV---------GK--------------------------------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEK--------NFVHRDLAARNVLLVN-----RHYA----KISDFGLSKAL------------GA---D--DSYY--------------TARSAGKWPLKWYAPECIN------FRK---FSSRSDVWSYGVTMWEALSYGQ--------------KP---------------YKKM-----KGPEVMAFI----EQ----GKR----MECPPECP------------------------------PELYA-LMSDCWIYKWEDRPD-----FLTVEQR--M-----------
|