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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK DDR1 203
TK ABL1 261
TK ABL2 288
TKL BRAF 456
TK CSF1R 582
TK EPHA1 624
TK EPHA3 621
TK FGFR1 478
TK FLT1 827
TK FLT4 845
TK KDR 834
TK KIT 589
TK LCK 245
TKL LIMK1 339
TKL LIMK2 331
CMGC MAPK14 24
TK MUSK 575
TK NTRK2 538
TK NTRK3 538
TK PDGFRA 593
TK PDGFRB 600
TK TEK 824
TK TIE1 839
--LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAV-KILR-P-DAT-KNARNDFL-KEVKIMSRL-KDPNIIRLLGVCV-Q------DDPLCMITDYMENGDLNQFLSAHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNL-------------YA--GDYY--------------RVQGRAVLPIRWMAWECIL-MGK---FTTASDVWAFGVTLWEVLMLCRAQPFGQL-TDEQVIENAGEFFRDQGRQ-VYLSRPPACP------------------------------QGLYELMLRCWSRESEQRPPFSQLHRFL---
--ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAV-KTLK-E-DTM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCT-R------EPPFYIITEFMTYGNLLDYLREC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--------------T--GDTY--------------TAHAGAKFPIKWTAPESLA-YNK---FSIKSDVWAFGVLLWEIATYGM-SPYPGI-DLSQVYELL----EKDYR----MERPEGCP------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F-
--ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAV-KTLK-E-DTM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCT-L------EPPFYIVTEYMPYGNLLDYLREC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM--------------T--GDTY--------------TAHAGAKFPIKWTAPESLA-YNT---FSIKSDVWAFGVLLWEIATYGM-SPYPGI-DLSQVYDLL----EKGYR----MEQPEGCP------------------------------PKVYELMRACWKWSPADRPSFAETHQA--F-
--ITVGQRIGSGSFGTVYKGKWH-------------------GDVAV-KMLN-VTAPT-PQQLQAFK-NEVGVLRKT-RHVNILLFMGYST--------KPQLAIVTQWCEGSSLYHHLHII--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK-------------SR--WSGS--------------HQFEQLSGSILWMAPEVIR-MQDKNPYSFQSDVYAFGIVLYELMT-GQ-LPYSNINNRDQIIFMV----GRGYLSPDLSKVRSNCP------------------------------KAMKRLMAECLKKKRDERPLFPQILA---SI
--LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAV-KMLK-S-TAH-ADEKEALM-SELKIMSHLGQHENIVNLLGACT-H------GGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI-------------MN--DSNY--------------IVKGNARLPVKWMAPESIF-DCV---YTVQSDVWSYGILLWEIFSLGL-NPYPGILVNSKFYKLV----KDGYQ----MAQPAFAP------------------------------KNIYSIMQACWALEPTHRPTFQQICSFL---
LM--VDTVIGEGEFGEVYRGTLR-------------LPSQDCKTVAI-KTLK-D-TSP-GGQWWNFL-REATIMGQF-SHPHILHLEGVVT-K------RKPIMIITEFMENGALDAFLRER--------------------------------------------------------------------------------------------------EDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLL-------------DD--FDGT--------------YETQGGKIPIRWTAPEAIA-HRI---FTTASDVWSFGIVMWEVLSFGD-KPYGEM-SNQEVMKSI----EDGYR----LPPPVDCP------------------------------APLYELMKNCWAYDRARRPHFQKLQAHL---
-I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEISVAI-KTLK-V-GYT-EKQRRDFL-GEASIMGQF-DHPNIIRLEGVVT-K------SKPVMIVTEYMENGSLDSFLRKH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVL-------------ED--DPEA-------------AYTTRGGKIPIRWTSPEAIA-YRK---FTSASDVWSYGIVLWEVMSYGE-RPYWEM-SNQDVIKAV----DEGYR----LPPPMDCP------------------------------AALYQLMLDCWQKDRNNRPKFEQIVSIL---
-L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAV-KMLK-S-DAT-EKDLSDLI-SEMEMMKMIGKHKNIINLLGACT-Q------DGPLYVIVEYASKGNLREYLQARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI-------------HH--IDYY--------------KKTTNGRLPVKWMAPEALF-DRI---YTHQSDVWSFGVLLWEIFTLGG-SPYPGV-PVEELFKLL----KEGHR----MDKPSNCT------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL---
--LKLGKSLGRGAFGKVVQASAFG-----------IKKSPTCRTVAV-KMLK-E-GAT-ASEYKALM-TELKILTHIGHHLNVVNLLGACTKQ------GGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPR--------------------------------LDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDI-------------YK--NPDY--------------VRKGDTRLPLKWMAPESIF-DKI---YSTKSDVWSYGVLLWEIFSLGG-SPYPGVQMDEDFCSRL----REGMR----MRAPEYST------------------------------PEIYQIMLDCWHRDPKERPRFAELVEKL---
--LHLGRVLGYGAFGKVVEASAFG-----------IHKGSSCDTVAV-KMLK-E-GAT-ASEHRALM-SELKILIHIGNHLNVVNLLGACTKP------QGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDI-------------YK--DPDY--------------VRKGSARLPLKWMAPESIF-DKV---YTTQSDVWSFGVLLWEIFSLGA-SPYPGVQINEEFCQRL----RDGTR----MRAPELAT------------------------------PAIRRIMLNCWSGDPKARPAFSELVEIL---
--LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAV-KMLK-E-GAT-HSEHRALM-SELKILIHIGHHLNVVNLLGACTKP------GGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI-------------YK--DPDY--------------VRKGDARLPLKWMAPETIF-DRV---YTIQSDVWSFGVLLWEIFSLGA-SPYPGVKIDEEFCRRL----KEGTR----MRAPDYTT------------------------------PEMYQTMLDCWHGEPSQRPTFSELVEHL---
--LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAV-KMLK-P-SAH-LTEREALM-SELKVLSYLGNHMNIVNLLGACT-I------GGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI-------------KN--DSNY--------------VVKGNARLPVKWMAPESIF-NCV---YTFESDVWSYGIFLWELFSLGS-SPYPGMPVDSKFYKMI----KEGFR----MLSPEHAP------------------------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I-
--LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAV-KSLK-Q-GSM-SP--DAFL-AEANLMKQL-QHQRLVRLYAVVT--------QEPIYIITEYMENGSLVDFLKTP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--------------E--DNEY--------------TAREGAKFPIKWTAPEAIN-YGT---FTIKSDVWSFGILLTEIVTHGR-IPYPGM-TNPEVIQNL----ERGYR----MVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-
LI--HGEVLGKGCFGQAIKVTHR----------------ETGEVMVM-KELI---RFD-EETQRTFL-KEVKVMRCL-EHPNVLKFIGVLY-K------DKRLNFITEYIKGGTLRGIIKSM--------------------------------------------------------------------------------------------------DSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLM-------------VD--EKTQPEGLRS--LKKPDRKKRYTVVGNPYWMAPEMIN-GRS---YDEKVDVFSFGIVLCEIIGRVN-ADPDYLPRTMDFGLNV----RGFLD----RYCPPNCP------------------------------PSFFPITVRCCDLDPEKRPSFVKLEH---WL
LI--HGEVLGKGFFGQAIKVTHK-----------------ATGKVMVMKEL--I-RCD-EETQKTFL-TEVKVMRSL-DHPNVLKFIGVLY-K------DKKLNLLTEYIEGGTLKDFLRSM---------------------------------------------------------------------------------------------------DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATT------KKRTL-----RKNDRKKRYTVVGNPYWMAPEMLN-GKS---YDETVDIFSFGIVLCEIIGQVY-ADPDCLPRTLDFGLNV----KLFWE----KFVPTDCP------------------------------PAFFPLAAICCRLEPESRPAFSKLED---SF
--YQNLSPVGSGAYGSVCAAFDT----------------KTGLRVAV-KKLSRP-FQSIIH--AKRTYRELRLLKHM-KHENVIGLLDVFT-PARSLEEFNDVYLVTHLMGA-DLNNIVKCQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----------------HTDDEM--------------TG---YVATRWYRAPEIMLNWMH---YNQTVDIWSVGCIMAELLT-GR-TLFPGT-DHIDQLKLI----LRLVG----TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-
-I-EYVRDIGEGAFGRVFQARAPG-----------LLPYEPFTMVAV-KMLK-E-EAS-ADMQADFQ-REAALMAEF-DNPNIVKLLGVCA-V------GKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNI-------------YS--ADYY--------------KANENDAIPIRWMPPESIF-YNR---YTTESDVWAYGVVLWEIFSYGL-QPYYGM-AHEEVIYYV----RDGNI----LSCPENCP------------------------------VELYNLMRLCWSKLPADRPSFTSIHRIL---
-I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKILVAV-KTLK-D-ASD-NA-RKDFH-REAELLTNL-QHEHIVKFYGVCV-E------GDPLIMVFEYMKHGDLNKFLRAHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDV-------------YS--TDYY--------------RVGGHTMLPIRWMPPESIM-YRK---FTTESDVWSLGVVLWEIFTYGK-QPWYQL-SNNEVIECI----TQGRV----LQRPRTCP------------------------------QEVYELMLGCWQREPHMRKNIKGIHTL--L-
-I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKMLVAV-KALK-D-PTL-AA-RKDFQ-REAELLTNL-QHEHIVKFYGVCG-D------GDPLIMVFEYMKHGDLNKFLRAHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDV-------------YS--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-YRK---FTTESDVWSFGVILWEIFTYGK-QPWFQL-SNTEVIECI----TQGRV----LERPRVCP------------------------------KEVYDVMLGCWQREPQQRLNIKEIYKIL---
-L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAV-KMLK-P-TAR-SSEKQALM-SELKIMTHLGPHLNIVNLLGACT-K------SGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI-------------MH--DSNY--------------VSKGSTFLPVKWMAPESIF-DNL---YTTLSDVWSYGILLWEIFSLGG-TPYPGMMVDSTFYNKI----KSGYR----MAKPDHAT------------------------------SEVYEIMVKCWNSEPEKRPSFYHLSE---IV
-L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAV-KMLK-S-TAR-SSEKQALM-SELKIMSHLGPHLNVVNLLGACT-K------GGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI-------------MR--DSNY--------------ISKGSTFLPLKWMAPESIF-NSL---YTTLSDVWSFGILLWEIFTLGG-TPYPELPMNEQFYNAI----KRGYR----MAQPAHAS------------------------------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL
--IKFQDVIGEGNFGQVLKARIK--------------KDGLRMDAAI-KRMK-E-YAS-KDDHRDFA-GELEVLCKLGHHPNIINLLGACE-H------RGYLYLAIEYAPHGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ------------------EVY--------------VKKTMGRLPVRWMAIESLN-YSV---YTTNSDVWSYGVLLWEIVSLGG-TPYCGM-TCAELYEKL----PQGYR----LEKPLNCD------------------------------DEVYDLMRQCWREKPYERPSFAQILV---SL
--ITFEDLIGEGNFGQVIRAMIK--------------KDGLKMNAAI-KMLK-E-YAS-ENDHRDFA-GELEVLCKLGHHPNIINLLGACK-N------RGYLYIAIEYAPYGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGE------------------EVY--------------VKKTMGRLPVRWMAIESLN-YSV---YTTKSDVWSFGVLLWEIVSLGG-TPYCGM-TCAELYEKL----PQGYR----MEQPRNCD------------------------------DEVYELMRQCWRDRPYERPPFAQIALQ--L-
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