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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK DDR2 203
TK ABL1 261
TK ABL2 288
TKL ACVR1 208
TK ALK 1116
Other AURKA 133
Other AURKC 43
TK BLK 241
TKL BMPR1A 234
TKL BMPR1B 204
TK BMX 422
CAMK BRSK1 50
CAMK BRSK2 19
TK BTK 402
CMGC CDC2 4
CMGC CDC2L5 705
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDKL2 4
Other CHUK 15
TK CSF1R 582
TK CSK 195
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
TK DDR1 572
TK EGFR 712
Other EIF2AK2 267
TK EPHA1 624
TK EPHA2 613
TK EPHA3 621
TK EPHA4 621
TK EPHA5 675
TK EPHA6 631
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB4 615
TK EPHB6 670
TK ERBB4 718
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FRK 234
TK FYN 271
TK HCK 241
CMGC ICK 4
TK IGF1R 999
TK INSR 1023
TK INSRR 979
TKL IRAK4 186
TK ITK 363
TK JAK2 849
CAMK KIAA0999 66
TK KIT 589
TK LCK 245
TKL LIMK1 339
TKL LIMK2 331
TK LTK 510
TK LYN 247
CMGC MAK 4
CMGC MAPK1 13
CMGC MAPK14 24
CAMK MARK1 60
CAMK MARK2 53
CAMK MARK3 56
CAMK MARK4 59
TK MATK 235
CAMK MGC42105 74
TK MUSK 575
Other NEK1 4
Other NEK2 8
Other NEK4 6
Other NEK5 4
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
CAMK NUAK2 97
STE OXSR1 17
STE PAK2 249
STE PAK4 321
STE PAK6 407
TK PDGFRA 593
TK PDGFRB 600
AGC PKN1 615
Other PLK2 82
Other PLK3 62
AGC PRKCA 339
AGC PRKCB 342
TK PTK2B 425
TK PTK6 191
TKL RAF1 349
TK RET 724
TK ROS1 1945
Other SBK1 53
CAMK SIK1 27
CAMK SIK2 20
CAMK SNRK 16
TK SRC 270
TK SRMS 230
CAMK STK17A 61
STE STK24 24
STE STK39 63
TK SYK 371
TK TEC 370
TKL TGFBR1 205
TK TNK1 116
TK TNK2 150
TK TXK 271
TK YES1 277
TK ZAP70 338
-------LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAV-KML---R-A--D-AN-KNA-RN-DFL-K----EIKIMSRL--K---DPNIIHLLAVCI--T-----------------------------DDPLCMITEYMENGDLNQFLS------------------------RHEPPN-----------------------------------------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSSL--------NFVHRDLATRNCLVG--K-----NYTI----KIADFGMSRNL-------------Y---S--GDYY--------------RIQGRAVLPIRWMSWESIL------LGK---FTTASDVWAFGVTLWETFTFCQE-------------QP---------------YSQL-----------SDEQV-IENT----GEFFRDQGRQ-TYLPQPAICP------------------------------DSVYK-LMLSCWRRDTKNRPS-----FQEIHL---LL-------------
-------ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAV-KTL---K-E--D-TM-EV---E-EFL-K----EAAVMKEI--K---HPNLVQLLGVCT--R-----------------------------EPPFYIITEFMTYGNLLDYLR------------------------EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVG--E-----NHLV----KVADFGLSRLM-----------------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNK---FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----------DLSQV-YELL----EK----DYR----MERPEGCP------------------------------EKVYE-LMRACWQWNPSDRPS-----FAEIHQA--F--------------
-------ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAV-KTL---K-E--D-TM-EV---E-EFL-K----EAAVMKEI--K---HPNLVQLLGVCT--L-----------------------------EPPFYIVTEYMPYGNLLDYLR------------------------EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVG--E-----NHVV----KVADFGLSRLM-----------------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNT---FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----------DLSQV-YDLL----EK----GYR----MEQPEGCP------------------------------PKVYE-LMRACWKWSPADRPS-----FAETHQA--F--------------
------I-TLLECVGKGRYGEVWRGSWQ----------------GEN--VAV-KIF---SSR--D-EKSWF---R-ET-------ELYNTVML--R---HENILGFIASDM--TSR-------------------------HSSTQLWLITHYHEMGSLYDYLQ------------------------LT----------------------------------------------------------------------------------------------------TLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVK--K-----NGQC----CIADLGLAVMHSQ-------------STNQLDVGN--------------NP---RVGTKRYMAPEVLDETIQVDCFD---SYKRVDIWAFGLVLWEVAR-RMVSNGI----VEDYKPP---------------FYDVVP------NDPSFEDM-RKVV----CV----DQQ----RPNIPNRWFSDPTL------------------------TSLAK-LMKECWYQNPSARLT-----ALRIKK----TL------------
------I-TLIRGLGHGAFGEVYEGQVSG-----------MPNDPSPLQVAV-KTL---P-E--V-CS-EQD-EL-DFL-M----EALIISKF--N---HQNIVRCIGVSL--Q-----------------------------SLPRFILLELMAGGDLKSFLR------------------------ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN--------HFIHRDIAARNCLLT--CP--GPGRVA----KIGDFGMARDI-------------Y---R--ASYY--------------RKGGCAMLPVKWMPPEAFM------EGI---FTSKTDTWSFGVLLWEIFSLGY--------------MP---------------YPSK-----------SNQEV-LEFV----TS----GGR----MDPPKNCP------------------------------GPVYR-IMTQCWQHQPEDRPN-----FAIILER--I--------------
-------FEIGRPLGKGKFGNVYLAREK----------------QSKFILAL-KVL---FKA--QLEKAGV---E-HQLRR----EVEIQSHL--R---HPNILRLYGYFH--D-----------------------------ATRVYLILEYAPLGTVYRELQ-----------------------KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK--------RVIHRDIKPENLLLG--S-----AGEL----KIADFGWSV-------------------HAPSSRR--------------TT---LCGTLDYLPPEMIE------GRM---HDEKVDLWSLGVLCYEFLV-GK--------------PP---------------FEAN--------------TY-QETY----KR----ISR----VEFTFPDFVT----------------------------EGARD-LISRLLKHNPSQRPM-----LREVLEHPWI--------------
-------FEIGRPLGKGKFGNVYLARLK----------------ESHFIVAL-KVL---FKS--Q-IEKEG---L-EHQLR---REIEIQAHL--Q---HPNILRLYNYFH--D-----------------------------ARRVYLILEYAPRGELYKELQ-----------------------KSE----------------------------------------------------------------------------------------------------KLDEQRTATIIEELADALTYCHDK--------KVIHRDIKPENLLLG--F-----RGEV----KIADFGWSV-------------------HTPSLRR--------------KT---MCGTLDYLPPEMIE------GRT---YDEKVDLWCIGVLCYELLV-GY--------------PP---------------FESA--------------SH-SETY----RR----ILK----VDVRFPLSMP----------------------------LGARD-LISRLLRYQPLERLP-----LAQILKHPWV--------------
------L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAI-KTL---K-E--G-TM-SP---E-AFL-G----EANVMKAL--Q---HERLVRLYAVVT--------------------------------KEPIYIVTEYMARGCLLDFLK------------------------TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERM--------NSIHRDLRAANILVS--E-----ALCC----KIADFGLARII--------------------DSEY--------------TAQEGAKFPIKWTAPEAIH------FGV---FTIKADVWSFGVLLMEVVTYGR--------------VP---------------YPGM-----------SNPEV-IRNL----ER----GYR----MPRPDTCP------------------------------PELYRGVIAECWRSRPEERPT-----FEFLQSV--L--------------
------I-QMVRQVGKGRYGEVWMGKWR----------------GEK--VAV-KVF---FTT--E-EASWF---R-ET-------EIYQTVLM--R---HENILGFIAADI--KGT-------------------------GSWTQLYLITDYHENGSLYDFLK------------------------CA----------------------------------------------------------------------------------------------------TLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIK--K-----NGSC----CIADLGLAVKFNS-------------DTNEVDVPL--------------NT---RVGTKRYMAPEVLDESLNKNHFQ---PYIMADIYSFGLIIWEMAR-RCITGGI----VEEYQLP---------------YYNMVP------SDPSYEDM-REVV----CV----KRL----RPIVSNRWNSDECL------------------------RAVLK-LMSECWAHNPASRLT-----ALRIKK----TL------------
------I-QMVKQIGKGRYGEVWMGKWR----------------GEK--VAV-KVF---FTT--E-EASWF---R-ET-------EIYQTVLM--R---HENILGFIAADI--KGT-------------------------GSWTQLYLITDYHENGSLYDYLK------------------------ST----------------------------------------------------------------------------------------------------TLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVK--K-----NGTC----CIADLGLAVKFIS-------------DTNEVDIPP--------------NT---RVGTKRYMPPEVLDESLNRNHFQ---SYIMADMYSFGLILWEVAR-RCVSGGIVEEYQLPYHD-------------------LVP------SDPSYEDM-REIV----CI----KKL----RPSFPNRWSSDECL------------------------RQMGK-LMTECWAHNPASRLT-----ALRVKK----TL------------
-------ITLLKELGSGQFGVVQLGKWK-----------------GQYDVAV-KMI---K-E--G-SM-SE---D-EFF-Q----EAQTMMKL--S---HPKLVKFYGVCS--K-----------------------------EYPIYIVTEYISNGCLLNYLR------------------------SH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESH--------QFIHRDLAARNCLVD--R-----DLCV----KVSDFGMTRYV-----------------L--DDQY--------------VSSVGTKFPVKWSAPEVFH------YFK---YSSKSDVWAFGILMWEVFSLGK--------------QP---------------YDLY-----------DNSQV-VLKV----SQ----GHR----LYRPHLAS------------------------------DTIYQ-IMYSCWHELPEKRPT-----FQQLLSS--I--------------
-------YRLEKTLGKGQTGLVKLGVHC----------------ITGQKVAI-KIV---NRE--K-LSESV---L-MKVER----EIAILKLI--E---HPHVLKLHDVYE--N-----------------------------KKYLYLVLEHVSGGELFDYLV-----------------------KKG----------------------------------------------------------------------------------------------------RLTPKEARKFFRQIVSALDFCHSY--------SICHRDLKPENLLLD--E-----KNNI----RIADFGMASL------------------QVGDSLL--------------ET---SCGSPHYACPEVIK-----GEKY---DGRRADMWSCGVILFALLV-GA--------------LP---------------FDDD--------------NL-RQLL----EK----VKR----GVFHMPHFIP----------------------------PDCQS-LLRGMIEVEPEKRLS-----LEQIQKHPW-Y-------------
-------YRLEKTLGKGQTGLVKLGVHC----------------VTCQKVAI-KIV---NRE--K-LSESV---L-MKVER----EIAILKLI--E---HPHVLKLHDVYE--N-----------------------------KKYLYLVLEHVSGGELFDYLV-----------------------KKG----------------------------------------------------------------------------------------------------RLTPKEARKFFRQIISALDFCHSH--------SICHRDLKPENLLLD--E-----KNNI----RIADFGMASL------------------QVGDSLL--------------ET---SCGSPHYACPEVIR-----GEKY---DGRKADVWSCGVILFALLV-GA--------------LP---------------FDDD--------------NL-RQLL----EK----VKR----GVFHMPHFIP----------------------------PDCQS-LLRGMIEVDAARRLT-----LEHIQKHIW-Y-------------
-------LTFLKELGTGQFGVVKYGKWR-----------------GQYDVAI-KMI---K-E--G-SM-SE---D-EFI-E----EAKVMMNL--S---HEKLVQLYGVCT--K-----------------------------QRPIFIITEYMANGCLLNYLR------------------------EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESK--------QFLHRDLAARNCLVN--D-----QGVV----KVSDFGLSRYV-----------------L--DDEY--------------TSSVGSKFPVRWSPPEVLM------YSK---FSSKSDIWAFGVLMWEIYSLGK--------------MP---------------YERF-----------TNSET-AEHI----AQ----GLR----LYRPHLAS------------------------------EKVYT-IMYSCWHEKADERPT-----FKILLSN--I--------------
-------YTKIEKIGEGTYGVVYKGRHK----------------TTGQVVAM-KKI---RLE--S-EEEGV---P-STAIR----EISLLKEL--R---HPNIVSLQDVLM--Q-----------------------------DSRLYLIFEFLSM-DLKKYLDS--------------------IPPGQ----------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSR--------RVLHRDLKPQNLLID--D-----KGTI----KLADFGLARAF-----------------GIPIRVY--------------TH---EVVTLWYRSPEVLL-----GSAR---YSTPVDIWSIGTIFAELAT-KK--------------PL---------------FHGD-----------SEIDQ-LFRI----FR----ALG----TPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-----GKMALNHPYF--------------
------F-DIIGIIGEGTYGQVYKARDK----------------DTGEMVAL-KKV---RLD--N-EKEGF---P-ITAIR----EIKILRQL--T---HQSIINMKEIVT--DKEDAL-------------------DFKKDKGAFYLVFEYMDH-DLMGLLE----------------------SGLV----------------------------------------------------------------------------------------------------HFNENHIKSFMRQLMEGLDYCHKK--------NFLHRDIKCSNILLN--N-----RGQI----KLADFGLARLY----------------SSEESRPY--------------TN---KVITLWYRPPELLL-----GEER---YTPAIDVWSCGCILGELFT-KK--------------PI---------------FQAN-----------QELAQ-LELI----SR----ICG----SPCPAVWPDVIKLPYFNTMKPKKQY-RRKLREEFVFIPAAALD-LFDYMLALDPSKRCT-----AEQALQCEF-L-------------
-------FQKVEKIGEGTYGVVYKARNK----------------LTGEVVAL-KKI---RLD--T-ETEGV---P-STAIR----EISLLKEL--N---HPNIVKLLDVIH--T-----------------------------ENKLYLVFEFLHQ-DLKKFMDA---------------------SALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH--------RVLHRDLKPQNLLIN--T-----EGAI----KLADFGLARAF-----------------GVPVRTY--------------TH---EVVTLWYRAPEILL-----GCKY---YSTAVDIWSLGCIFAEMVT-RR--------------AL---------------FPGD-----------SEIDQ-LFRI----FR----TLG----TPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-----AKAALAHPFF--------------
-------FQKVEKIGEGTYGVVYKAKNR----------------ETGQLVAL-KKI---RLD--L-EMEGV---P-STAIR----EISLLKEL--K---HPNIVRLLDVVH--N-----------------------------ERKLYLVFEFLSQ-DLKKYMDS---------------------TPGS----------------------------------------------------------------------------------------------------ELPLHLIKSYLFQLLQGVSFCHSH--------RVIHRDLKPQNLLIN--E-----LGAI----KLADFGLARAF-----------------GVPLRTY--------------TH---EVVTLWYRAPEILL-----GSKF---YTTAVDIWSIGCIFAEMVT-RK--------------AL---------------FPGD-----------SEIDQ-LFRI----FR----MLG----TPSEDTWPGVTQLPDYKGSFPKWTR--KGLEEIVPNLEPEGRD-LLMQLLQYDPSQRIT-----AKTALAHPYF--------------
-------YEKLEKIGEGTYGTVFKAKNR----------------ETHEIVAL-KRV---RLD--D-DDEGV---P-SSALR----EICLLKEL--K---HKNIVRLHDVLH--S-----------------------------DKKLTLVFEFCDQ-DLKKYFD----------------------SCNG----------------------------------------------------------------------------------------------------DLDPEIVKSFLFQLLKGLGFCHSR--------NVLHRDLKPQNLLIN--R-----NGEL----KLADFGLARAF-----------------GIPVRCY--------------SA---EVVTLWYRPPDVLF-----GAKL---YSTSIDMWSAGCIFAELANAGR--------------PL---------------FPGN-----------DVDDQ-LKRI----FR----LLG----TPTEEQWPSMTKLPDYKPYPMYPAT--TSLVNVVPKLNATGRD-LLQNLLKCNPVQRIS-----AEEALQHPYF--------------
-------YENLGLVGEGSYGMVMKCRNK----------------DTGRIVAI-KKF---LES--D-DDKMV---K-KIAMR----EIKLLKQL--R---HENLVNLLEVCK--K-----------------------------KKRWYLVFEFVDHTILDDLEL-----------------------FPN----------------------------------------------------------------------------------------------------GLDYQVVQKYLFQIINGIGFCHSH--------NIIHRDIKPENILVS--Q-----SGVV----KLCDFGFARTL-----------------AAPGEVY--------------TD---YVATRWYRAPELLV-----GDVK---YGKAVDVWAIGCLVTEMFM-GE--------------PL---------------FPGD-----------SDIDQ-LYHI----MM----CLG----NLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVID-LAKKCLHIDPDKRPF-----CAELLHHDFF--------------
------W-EMRERLGTGGFGNVCLYQHR----------------ELDLKIAI-KSC---RLE--L-STKNR---E-R-WCH----EIQIMKKL--N---HANVVKACDVPE--ELN------------------------ILIHDVPLLAMEYCSGGDLRKLLNK--------------------PENCC----------------------------------------------------------------------------------------------------GLKESQILSLLSDIGSGIRYLHEN--------KIIHRDLKPENIVLQ--D-----VGGKI-IHKIIDLGYAKD------------------VDQGSLC--------------TS---FVGTLQYLAPELFE------NKP---YTATVDYWSFGTMVFECIA-GY--------------RP---------------FLHHLQPFTWHEKIKKKDPK-CIFA----CE----EMS----GEVRFSSHLPQPNSLCS------------------LVVEPMEN-WLQLMLNWDPQQRG----------------GPVDLTLKQ-----
-------LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAV-KML---K-S--T-AH-ADE-KE-ALM-S----ELKIMSHLG-Q---HENIVNLLGACT--H-----------------------------GGPVLVITEYCCYGDLLNFLR------------------------RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASK--------NCIHRDVAARNVLLT--N-----GHVA----KIGDFGLARDI-------------M---N--DSNY--------------IVKGNARLPVKWMAPESIF------DCV---YTVQSDVWSYGILLWEIFSLGL--------------NP---------------YPGI-L---------VNSKF-YKLV----KD----GYQ----MAQPAFAP------------------------------KNIYS-IMQACWALEPTHRPT-----FQQICSFL----------------
-------LKLLQTIGKGEFGDVMLGDYR------------------GNKVAV-KCI---K-N--D-AT-AQ-----AFL-A----EASVMTQL--R---HSNLVQLLGVIV-EE-----------------------------KGGLYIVTEYMAKGSLVDYLR------------------------SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGN--------NFVHRDLAARNVLVS--E-----DNVA----KVSDFGLTKEA-----------------------S--------------STQDTGKLPVKWTAPEALR------EKK---FSTKSDVWSFGILLWEIYSFGR--------------VP---------------YPRI-----------PLKDV-VPRV----EK----GYK----MDAPDGCP------------------------------PAVYE-VMKNCWHLDAAMRPS-----FLQLREQL----------------
-------YDTGEELGSGQFAVVKKCREK----------------STGLQYAA-KFI---KKR--R-TKSSR---R-GVSREDIEREVSILKEI--Q---HPNVITLHEVYE--N-----------------------------KTDVILILELVAGGELFDFLA-----------------------EKE----------------------------------------------------------------------------------------------------SLTEEEATEFLKQILNGVYYLHSL--------QIAHFDLKPENIMLL--D-----RNVPKPRIKIIDFGLAHK------------------IDFGNEF--------------KN---IFGTPEFVAPEIVN------YEP---LGLEADMWSIGVITYILLS-GA--------------SP---------------FLGD--------------TK-QETL----AN----VSA----VNYEFEDEYFSNTS------------------------ALAKD-FIRRLLVKDPKKRMT-----IQDSLQHPWI--------------
-------YDIGEELGSGQFAIVKKCREK----------------STGLEYAA-KFI---KKR--Q-SRASR---R-GVSREEIEREVSILRQV--L---HHNVITLHDVYE--N-----------------------------RTDVVLILELVSGGELFDFLA-----------------------QKE----------------------------------------------------------------------------------------------------SLSEEEATSFIKQILDGVNYLHTK--------KIAHFDLKPENIMLL--D-----KNIPIPHIKLIDFGLAHE------------------IEDGVEF--------------KN---IFGTPEFVAPEIVN------YEP---LGLEADMWSIGVITYILLS-GA--------------SP---------------FLGD--------------TK-QETL----AN----ITA----VSYDFDEEFFSQTS------------------------ELAKD-FIRKLLVKETRKRLT-----IQEALRHPWI--------------
-------YEMGEELGSGQFAIVRKCRQK----------------GTGKEYAA-KFI---KKR--R-LSSSR---R-GVSREEIEREVNILREI--R---HPNIITLHDIFE--N-----------------------------KTDVVLILELVSGGELFDFLA-----------------------EKE----------------------------------------------------------------------------------------------------SLTEDEATQFLKQILDGVHYLHSK--------RIAHFDLKPENIMLL--D-----KNVPNPRIKLIDFGIAHK------------------IEAGNEF--------------KN---IFGTPEFVAPEIVN------YEP---LGLEADMWSIGVITYILLS-GA--------------SP---------------FLGE--------------TK-QETL----TN----ISA----VNYDFDEEYFSNTS------------------------ELAKD-FIRRLLVKDPKRRMT-----IAQSLEHSWI--------------
-------LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAV-KIL---R-P--D-AT-KNA-RN-DFL-K----EVKIMSRL--K---DPNIIRLLGVCV--Q-----------------------------DDPLCMITDYMENGDLNQFLS------------------------AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATL--------NFVHRDLATRNCLVG--E-----NFTI----KIADFGMSRNL-------------Y---A--GDYY--------------RVQGRAVLPIRWMAWECIL------MGK---FTTASDVWAFGVTLWEVLMLCRA-------------QP---------------FGQL-----------TDEQV-IENAGEFFRD----QGRQ-VYLSRPPACP------------------------------QGLYE-LMLRCWSRESEQRPP-----FSQLHRFL----------------
------F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKIPVAI-KEL---R-E--A-TS-PKA-NK-EIL-D----EAYVMASV--D---NPHVCRLLGICL--------------------------------TSTVQLITQLMPFGCLLDYVR------------------------EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR--------RLVHRDLAARNVLVK--T-----PQHV----KITDFGLAKLL-------------G---A--EEKE--------------YHAEGGKVPIKWMALESIL------HRI---YTHQSDVWSYGVTVWELMTFGS--------------KP---------------YDGI-----------PASEI-SSIL----EK----GER----LPQPPICT------------------------------IDVYM-IMVKCWMIDADSRPK-----FRELI----IEF------------
------F-KEIELIGSGGFGQVFKAKHR----------------IDGKTYVI-KRV---KYN--N-EKAER--------------EVKALAKL--D---HVNIVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK---------------------RRGE----------------------------------------------------------------------------------------------------KLDKVLALELFEQITKGVDYIHSK--------KLIHRDLKPSNIFLV--D-----TKQV----KIGDFGLVTS------------------LKNDGKR--------------TR---SKGTLRYMSPEQIS------SQD---YGKEVDLYALGLILAELLH-VC-------------DTA---------------FET-------------------SKF----FT----DLR----DGIISDIFDK-----------------------------KEKT-LLQKLLSKKPEDRPN-----TSEILR----TLT-----------
-----LM--VDTVIGEGEFGEVYRGTLR-------------LPSQDCKTVAI-KTL---K-D--T-SP-GGQ-WW-NFL-R----EATIMGQF--S---HPHILHLEGVVT--K-----------------------------RKPIMIITEFMENGALDAFLR------------------------ER--------------------------------------------------------------------------------------------------EDQLVPGQLVAMLQGIASGMNYLSNH--------NYVHRDLAARNILVN--Q-----NLCC----KVSDFGLTRLL-------------D---D--FDGT--------------YETQGGKIPIRWTAPEAIA------HRI---FTTASDVWSFGIVMWEVLSFGD--------------KP---------------YGEM-----------SNQEV-MKSI----ED----GYR----LPPPVDCP------------------------------APLYE-LMKNCWAYDRARRPH-----FQKLQAHL----------------
------V-TRQKVIGAGEFGEVYKGMLKT------------SSGKKEVPVAI-KTL---K-A--G-YT-EKQ-RV-DFL-G----EAGIMGQF--S---HHNIIRLEGVIS--K-----------------------------YKPMMIITEYMENGALDKFLR------------------------EK--------------------------------------------------------------------------------------------------DGEFSVLQLVGMLRGIAAGMKYLANM--------NYVHRDLAARNILVN--S-----NLVC----KVSDFGLSRVL-------------E---D--DPEA-------------TYTTSGGKIPIRWTAPEAIS------YRK---FTSASDVWSFGIVMWEVMTYGE--------------RP---------------YWEL-----------SNHEV-MKAI----ND----GFR----LPTPMDCP------------------------------SAIYQ-LMMQCWQQERARRPK-----FADIVSIL----------------
------I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEISVAI-KTL---K-V--G-YT-EKQ-RR-DFL-G----EASIMGQF--D---HPNIIRLEGVVT--K-----------------------------SKPVMIVTEYMENGSLDSFLR------------------------KH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDM--------GYVHRDLAARNILIN--S-----NLVC----KVSDFGLSRVL-------------E---D--DPEA-------------AYTTRGGKIPIRWTSPEAIA------YRK---FTSASDVWSYGIVLWEVMSYGE--------------RP---------------YWEM-----------SNQDV-IKAV----DE----GYR----LPPPMDCP------------------------------AALYQ-LMLDCWQKDRNNRPK-----FEQIVSIL----------------
-------IKIEKVIGVGEFGEVCSGRLK-------------VPGKREICVAI-KTL---K-A--G-YT-DKQ-RR-DFL-S----EASIMGQF--D---HPNIIHLEGVVT--K-----------------------------CKPVMIITEYMENGSLDAFLR------------------------KN--------------------------------------------------------------------------------------------------DGRFTVIQLVGMLRGIGSGMKYLSDM--------SYVHRDLAARNILVN--S-----NLVC----KVSDFGMSRVL-------------E---D--DPEA-------------AYTTRGGKIPIRWTAPEAIA------YRK---FTSASDVWSYGIVMWEVMSYGE--------------RP---------------YWDM-----------SNQDV-IKAI----EE----GYR----LPPPMDCP------------------------------IALHQ-LMLDCWQKERSDRPK-----FGQIVNML----------------
-------ITIERVIGAGEFGEVCSGRLK-------------LPGKRELPVAI-KTL---K-V--G-YT-EKQ-RR-DFL-G----EASIMGQF--D---HPNIIHLEGVVT--K-----------------------------SKPVMIVTEYMENGSLDTFLK------------------------KN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGISAGMKYLSDM--------GYVHRDLAARNILIN--S-----NLVC----KVSDFGLSRVL-------------E---D--DPEA-------------AYTTRGGKIPIRWTAPEAIA------FRK---FTSASDVWSYGIVMWEVVSYGE--------------RP---------------YWEM-----------TNQDV-IKAV----EE----GYR----LPSPMDCP------------------------------AALYQ-LMLDCWQKERNSRPK-----FDEIVNML----------------
LPPRIPA----------------------------------------------------------------------------------------------------------------------------------------GRPVMIVVEYMENGSLDSFLR------------------------KH--------------------------------------------------------------------------------------------------DGHFTVIQLVGMLRGIASGMKYLSDM--------GYVHRDLAARNILVN--S-----NLVC----KVSDFGLSRVL-------------E---D--DPEA-------------AYTTTGGKIPIRWTAPEAIA------YRK---FSSASDAWSYGIVMWEVMSYGE--------------RP---------------YWEM-----------SNQDV-ILSI----EE----GYR----LPAPMGCP------------------------------ASLHQ-LMLHCWQKERNHRPK-----FTDIVSFL----------------
-------IHIEKIIGSGDSGEVCYGRLR-------------VPGQRDVPVAI-KAL---K-A--G-YT-ERQ-RR-DFL-S----EASIMGQF--D---HPNIIRLEGVVT--R-----------------------------GRLAMIVTEYMENGSLDTFLR------------------------TH--------------------------------------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSDL--------GYVHRDLAARNVLVD--S-----NLVC----KVSDFGLSRVL-------------E---D--DPDA-------------AYTTTGGKIPIRWTAPEAIA------FRT---FSSASDVWSFGVVMWEVLAYGE--------------RP---------------YWNM-----------TNRDV-ISSV----EE----GYR----LPAPMGCP------------------------------HALHQ-LMLDCWHKDRAQRPR-----FSQIVSVL----------------
------V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREIYVAI-KTL---K-A--G-YS-EKQ-RR-DFL-S----EASIMGQF--D---HPNIIRLEGVVT--K-----------------------------SRPVMIITEFMENGALDSFLR------------------------QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEM--------NYVHRDLAARNILVN--S-----NLVC----KVSDFGLSRYLQ----------DDT---S--DPTY--------------TSSLGGKIPVRWTAPEAIA------YRK---FTSASDVWSYGIVMWEVMSFGE--------------RP---------------YWDM-----------SNQDV-INAI----EQ----DYR----LPPPMDCP------------------------------AALHQ-LMLDCWQKDRNSRPR-----FAEIVNTL----------------
------V-KIEQVIGAGEFGEVCSGHLK-------------LPGKREIFVAI-KTL---K-S--G-YT-EKQ-RR-DFL-S----EASIMGQF--D---HPNVIHLEGVVT--K-----------------------------STPVMIITEFMENGSLDSFLR------------------------QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADM--------NYVHRDLAARNILVN--S-----NLVC----KVSDFGLSRFLE----------DDT---S--DPTY--------------TSALGGKIPIRWTAPEAIQ------YRK---FTSASDVWSYGIVMWEVMSYGE--------------RP---------------YWDM-----------TNQDV-INAI----EQ----DYR----LPPPMDCP------------------------------SALHQ-LMLDCWQKDRNHRPK-----FGQIVNTL----------------
------V-KIEEVIGAGEFGEVCRGRLK-------------APGKKESCVAI-KTL---K-G--G-YT-ERQ-RR-EFL-S----EASIMGQF--E---HPNIIRLEGVVT--N-----------------------------SMPVMILTEFMENGALDSFLR------------------------LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEM--------SYVHRDLAARNILVN--S-----NLVC----KVSDFGLSRFLE----------ENS---S--DPTY--------------TSSLGGKIPIRWTAPEAIA------FRK---FTSASDAWSYGIVMWEVMSFGE--------------RP---------------YWDM-----------SNQDV-INAI----EQ----DYR----LPPPPDCP------------------------------TSLHQ-LMLDCWQKDRNARPR-----FPQVVSAL----------------
-------IKIEEVIGTGSFGEVRQGRLQ-------------PRGRREQTVAI-QAL---W-A--G-GA-ESL-QM-TFL-G----RAAVLGQF--Q---HPNILRLEGVVT--K-----------------------------SRPLMVLTEFMELGPLDSFLR------------------------QR--------------------------------------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSF--------AFVHRSLSAHSVLVN--S-----HLVC----KVARLGHSPQG-------------------------------------------PSCLLRWAAPEVIA------HGK---HTTSSDVWSFGILMWEVMSYGE--------------RP---------------YWDM-----------SEQEV-LNAI----EQ----EFR----LPPPPGCP------------------------------PGLHL-LMLDTWQKDRARRPH-----FDQLVA---AF-------------
------L-KRVKVLGSGAFGTVYKGIWVP------------EGETVKIPVAI-KIL---N-E--T-TG-PKA-NV-EFM-D----EALIMASM--D---HPHLVRLLGVCL--------------------------------SPTIQLVTQLMPHGCLLEYVH------------------------EH--------------------------------------------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEER--------RLVHRDLAARNVLVK--S-----PNHV----KITDFGLARLL-------------E---G--DEKE--------------YNADGGKMPIKWMALECIH------YRK---FTHQSDVWSYGVTIWELMTFGG--------------KP---------------YDGI-----------PTREI-PDLL----EK----GER----LPQPPICT------------------------------IDVYM-VMVKCWMIDADSRPK-----FKELAAE--F--------------
------L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAV-KML---K-S--D-AT-EKD-LS-DLI-S----EMEMMKMIG-K---HKNIINLLGACT--Q-----------------------------DGPLYVIVEYASKGNLREYLQ------------------------ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--------KCIHRDLAARNVLVT--E-----DNVM----KIADFGLARDI-------------H---H--IDYY--------------KKTTNGRLPVKWMAPEALF------DRI---YTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGV-----------PVEEL-FKLL----KE----GHR----MDKPSNCT------------------------------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL----------------
-------LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAV-KML---K-D--D-AT-EKD-LS-DLV-S----EMEMMKMIG-K---HKNIINLLGACT--Q-----------------------------DGPLYVIVEYASKGNLREYLR------------------------ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ--------KCIHRDLAARNVLVT--E-----NNVM----KIADFGLARDI-------------N---N--IDYY--------------KKTTNGRLPVKWMAPEALF------DRV---YTHQSDVWSFGVLMWEIFTLGG--------------SP---------------YPGI-----------PVEEL-FKLL----KE----GHR----MDKPANCT------------------------------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL----------------
-------LTLGKPLGEGCFGQVVMAEAIGI---------DKDRAAKPVTVAV-KML---K-D--D-AT-DKD-LS-DLV-S----EMEMMKMIG-K---HKNIINLLGACT--Q-----------------------------GGPLYVLVEYAAKGNLREFLR------------------------ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQ--------KCIHRDLAARNVLVT--E-----DNVM----KIADFGLARDV-------------H---N--LDYY--------------KKTTNGRLPVKWMAPEALF------DRV---YTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGI-----------PVEEL-FKLL----KE----GHR----MDKPANCT------------------------------HDLYM-IMRECWHAAPSQRPT-----FKQLVEDL----------------
------L-VLGKPLGEGCFGQVVRAEAFGM---------DPARPDQASTVAV-KML---K-D--N-AS-DKD-LA-DLV-S----EMEVMKLIG-R---HKNIINLLGVCT--Q-----------------------------EGPLYVIVECAAKGNLREFLR------------------------ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESR--------KCIHRDLAARNVLVT--E-----DNVM----KIADFGLARGV-------------H---H--IDYY--------------KKTSNGRLPVKWMAPEALF------DRV---YTHQSDVWSFGILLWEIFTLGG--------------SP---------------YPGI-----------PVEEL-FSLL----RE----GHR----MDRPPHCP------------------------------PELYG-LMRECWHAAPSQRPT-----FKQLVEAL----------------
-------ITLERRLGTGCFGDVWLGTWN-----------------GSTKVAV-KTL---K-P--G-TM-SP---K-AFL-E----EAQVMKLL--R---HDKLVQLYAVVS--------------------------------EEPIYIVTEFMCHGSLLDFLK------------------------NP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERM--------NYIHRDLRAANILVG--E-----RLAC----KIADFGLARLI-----------------K--DDEY--------------NPCQGSKFPIKWTAPEAAL------FGR---FTIKSDVWSFGILLTELITKGR--------------IP---------------YPGM-----------NKREV-LEQV----EQ----GYH----MPCPPGCP------------------------------ASLYE-AMEQTWRLDPEERPT-----FEYLQSFL----------------
-------IQLLKRLGSGQFGEVWEGLWN-----------------NTTPVAV-KTL---K-P--G-SM-DP---N-DFL-R----EAQIMKNL--R---HPKLIQLYAVCT--L-----------------------------EDPIYIITELMRHGSLQEYLQ------------------------ND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESR--------NYIHRDLAARNVLVG--E-----HNIY----KVADFGLARVFK-----------VD---N--EDIY--------------ESRHEIKLPVKWTAPEAIR------SNK---FSIKSDVWSFGILLYEIITYGK--------------MP---------------YSGM-----------TGAQV-IQML----AQ----NYR----LPQPSNCP------------------------------QQFYN-IMLECWNAEPKERPT-----FETLRWK--L--------------
-------LQLIKRLGNGQFGEVWMGTWN-----------------GNTKVAI-KTL---K-P--G-TM-SP---E-SFL-E----EAQIMKKL--K---HDKLVQLYAVVS--------------------------------EEPIYIVTEYMNKGSLLDFLK------------------------DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERM--------NYIHRDLRSANILVG--N-----GLIC----KIADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELVTKGR--------------VP---------------YPGM-----------NNREV-LEQV----ER----GYR----MPCPQDCP------------------------------ISLHE-LMIHCWKKDPEERPT-----FEYLQSFL----------------
-------LKLEKKLGAGQFGEVWMATYN-----------------KHTKVAV-KTM---K-P--G-SM-SV---E-AFL-A----EANVMKTL--Q---HDKLVKLHAVVT--------------------------------KEPIYIITEFMAKGSLLDFLK------------------------SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR--------NYIHRDLRAANILVS--A-----SLVC----KIADFGLARVI-----------------E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGS---FTIKSDVWSFGILLMEIVTYGR--------------IP---------------YPGM-----------SNPEV-IRAL----ER----GYR----MPRPENCP------------------------------EELYN-IMMRCWKNRPEERPT-----FEYIQSV--L--------------
-------YTTIRQLGDGTYGSVLLGRSI----------------ESGELIAI-KKM---KRK--F-YSWEE---C--MNLR----EVKSLKKL--N---HANVVKLKEVIR--E-----------------------------NDHLYFIFEYMKE-NLYQLIK----------------------ERNK----------------------------------------------------------------------------------------------------LFPESAIRNIMYQILQGLAFIHKH--------GFFHRDLKPENLLCM--G-----PELV----KIADFGLARE------------------IRSKPPY--------------TD---YVSTRWYRAPEVLL-----RSTN---YSSPIDVWAVGCIMAEVYT-LR--------------PL---------------FPGA-----------SEIDT-IFKI----CQ----VLG----TPKKTDWPEGYQLSSAMNFRWPQCV-PNNLKTLIPNASSEAVQ-LLRDMLQWDPKKRPT-----ASQALRYPYF--------------
-------ITMSRELGQGSFGMVYEGVAKG-----------VVKDEPETRVAI-KTV---N-E--A-AS-MRE-RI-EFL-N----EASVMKEF--N---CHHVVRLLGVVS--Q-----------------------------GQPTLVIMELMTRGDLKSYLR------------------------SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNAN--------KFVHRDLAARNCMVA--E-----DFTV----KIGDFGMTRDI-------------Y---E--TDYY--------------RKGGKGLLPVRWMSPESLK------DGV---FTTYSDVWSFGVVLWEIATLAE--------------QP---------------YQGL-----------SNEQV-LRFV----ME----GGL----LDKPDNCP------------------------------DMLFE-LMRMCWQYNPKMRPS-----FLEIISS--I--------------
-------ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAV-KTV---N-E--S-AS-LRE-RI-EFL-N----EASVMKGF--T---CHHVVRLLGVVS--K-----------------------------GQPTLVVMELMAHGDLKSYLR------------------------SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK--------KFVHRDLAARNCMVA--H-----DFTV----KIGDFGMTRDI-------------Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK------DGV---FTTSSDMWSFGVVLWEITSLAE--------------QP---------------YQGL-----------SNEQV-LKFV----MD----GGY----LDQPDNCP------------------------------ERVTD-LMRMCWQFNPKMRPT-----FLEIVNLL----------------
------I-SIIRELGQGSFGMVYEGLARG-----------LEAGEESTPVAL-KTV---N-E--L-AS-PRE-CI-EFL-K----EASVMKAF--K---CHHVVRLLGVVS--Q-----------------------------GQPTLVIMELMTRGDLKSHLR------------------------SLRPEA-----------------------------------------------------------------------------------------ENNPGLPQPALGEMIQMAGEIADGMAYLAAN--------KFVHRDLAARNCMVS--Q-----DFTV----KIGDFGMTRDV-------------Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK------DGI---FTTHSDVWSFGVVLWEIVTLAE--------------QP---------------YQGL-----------SNEQV-LKFV----MD----GGV----LEELEGCP------------------------------LQLQE-LMSRCWQPNPRLRPS-----FTHILD---SI-------------
----VGG----NKMGEGGFGVVYKGYVN----------------NTT--VAV-KKL---AAM--V-DITTE---ELKQQFD---QEIKVMAKC--Q---HENLVELLGFSS--D-----------------------------GDDLCLVYVYMPNGSLLDRLSC--------------------LDGTP----------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN--------HHIHRDIKSANILLD--E-----AFTA----KISDFGLARASE---------------KFAQTVMT--------------SR---IVGTTAYMAPEALR-------GE---ITPKSDIYSFGVVLLEIIT-GL--------------PA---------------VDEH-----------REPQL-LLDI----KE----EIE----DEEKTIEDYIDKKMNDAD----------------STSVEAMYS-VASQCLHEKKNKRPD-----IKKVQQ----LLQ-----------
-------LTFVQEIGSGQFGLVHLGYWL-----------------NKDKVAI-KTI---R-E--G-AM-SE---E-DFI-E----EAEVMMKL--S---HPKLVQLYGVCL--E-----------------------------QAPICLVFEFMEHGCLSDYLR------------------------TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEA--------CVIHRDLAARNCLVG--E-----NQVI----KVSDFGMTRFV-----------------L--DDQY--------------TSSTGTKFPVKWASPEVFS------FSR---YSSKSDVWSFGVLMWEVFSEGK--------------IP---------------YENR-----------SNSEV-VEDI----ST----GFR----LYKPRLAS------------------------------THVYQ-IMNHCWKERPEDRPA-----FSRLLRQL----------------
-------LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAV-KKL---Q-H--S-TE--EH-LR-DFE-R----EIEILKSL--Q---HDNIVKYKGVCYSAG-----------------------------RRNLKLIMEYLPYGSLRDYLQ------------------------KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK--------RYIHRDLATRNILVE--N-----ENRV----KIGDFGLTKVL------------PQ---D--KEYY--------------KVKEPGESPIFWYAPESLT------ESK---FSVASDVWSFGVVLYELFTYIE--------------KSKSPPAEFMRMIGNDKQGQM-----------IVFHL-IELL----KN----NGR----LPRPDGCP------------------------------DEIYM-IMTECWNNNVNQRPS-----FRDLA----LRV------------
-------YEIDRTIGKGNFAVVKRATHL----------------VTKAKVAI-KII---DKT--Q-LDEEN---L-KKIFR----EVQIMKML--C---HPHIIRLYQVME--T-----------------------------ERMIYLVTEYASGGEIFDHLV-----------------------AHG----------------------------------------------------------------------------------------------------RMAEKEARRKFKQIVTAVYFCHCR--------NIVHRDLKAENLLLD--A-----NLNI----KIADFGFSNL------------------FTPGQLL--------------KT---WCGSPPYAAPELFE-----GKEY---DGPKVDIWSLGVVLYVLVC-GA--------------LP---------------FDGS--------------TL-QNLR----AR----VLS----GKFRIPFFMS----------------------------TECEH-LIRHMLVLDPNKRLS-----MEQICKHKWM--------------
-------LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAV-KML---K-P--S-AH-LTE-RE-ALM-S----ELKVLSYLG-N---HMNIVNLLGACT--I-----------------------------GGPTLVITEYCCYGDLLNFLR------------------------RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK--------NCIHRDLAARNILLT--H-----GRIT----KICDFGLARDI-------------K---N--DSNY--------------VVKGNARLPVKWMAPESIF------NCV---YTFESDVWSYGIFLWELFSLGS--------------SP---------------YPGM-P---------VDSKF-YKMI----KE----GFR----MLSPEHAP------------------------------AEMYD-IMKTCWDADPLKRPT-----FKQIVQL--I--------------
-------LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAV-KSL---K-Q--G-SM-SP---D-AFL-A----EANLMKQL--Q---HQRLVRLYAVVT--------------------------------QEPIYIITEYMENGSLVDFLK------------------------TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVS--D-----TLSC----KIADFGLARLI-----------------E--DNEY--------------TAREGAKFPIKWTAPEAIN------YGT---FTIKSDVWSFGILLTEIVTHGR--------------IP---------------YPGM-----------TNPEV-IQNL----ER----GYR----MVRPDNCP------------------------------EELYQ-LMRLCWKERPEDRPT-----FDYLRSV--L--------------
-----LI--HGEVLGKGCFGQAIKVTHR----------------ETGEVMVM-KEL---I----R-FD-EET-QR-TFL-K----EVKVMRCL--E---HPNVLKFIGVLY--K-----------------------------DKRLNFITEYIKGGTLRGIIK------------------------SM--------------------------------------------------------------------------------------------------DSQYPWSQRVSFAKDIASGMAYLHSM--------NIIHRDLNSHNCLVR--E-----NKNV----VVADFGLARLM-------------V---D--EKTQPEGLRS--LKKPDRKKRYTVVGNPYWMAPEMIN------GRS---YDEKVDVFSFGIVLCEIIGRVN--------------AD---------------PDYL-P---------RTMDF-GLNV----RG----FLD----RYCPPNCP------------------------------PSFFP-ITVRCCDLDPEKRPS-----FVKLEH---WL-------------
-----LI--HGEVLGKGFFGQAIKVTHK-----------------ATGKVMVMKEL-----I--R-CD-EET-QK-TFL-T----EVKVMRSL--D---HPNVLKFIGVLY--K-----------------------------DKKLNLLTEYIEGGTLKDFLR------------------------SM---------------------------------------------------------------------------------------------------DPFPWQQKVRFAKGIASGMAYLHSM--------CIIHRDLNSHNCLIK--L-----DKTV----VVADFGLSRLIVEERKRAPMEKATT---------KKRTL-----RKNDRKKRYTVVGNPYWMAPEMLN------GKS---YDETVDIFSFGIVLCEIIGQVY--------------AD---------------PDCL-P---------RTLDF-GLNV----KL----FWE----KFVPTDCP------------------------------PAFFP-LAAICCRLEPESRPA-----FSKLED---SF-------------
------V-TLLRALGHGAFGEVYEGLVIG-----------LPGDSSPLQVAI-KTL---P-E--L-CS-PQD-EL-DFL-M----EALIISKF--R---HQNIVRCVGLSL--R-----------------------------ATPRLILLELMSGGDMKSFLR------------------------HSRP--------------------------------------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEEN--------HFIHRDIAARNCLLS--CA--GPSRVA----KIGDFGMARDI-------------Y---R--ASYY--------------RRGDRALLPVKWMPPEAFL------EGI---FTSKTDSWSFGVLLWEIFSLGY--------------MP---------------YPGR-----------TNQEV-LDFV----VG----GGR----MDPPRGCP------------------------------GPVYR-IMTQCWQHEPELRPS-----FASILERL----------------
-------IKLVKRLGAGQFGEVWMGYYN-----------------NSTKVAV-KTL---K-P--G-TM-SV---Q-AFL-E----EANLMKTL--Q---HDKLVRLYAVVT--R-----------------------------EEPIYIITEYMAKGSLLDFLK------------------------SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERK--------NYIHRDLRAANVLVS--E-----SLMC----KIADFGLARVI-----------------E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGC---FTIKSDVWSFGILLYEIVTYGK--------------IP---------------YPGR-----------TNADV-MTAL----SQ----GYR----MPRVENCP------------------------------DELYD-IMKMCWKEKAEERPT-----FDYLQSV--L--------------
-------YTTMRQLGDGTYGSVLMGKSN----------------ESGELVAI-KRM---KRK--F-YSWDE---C-M-NLR----EVKSLKKL--N---HANVIKLKEVIR--E-----------------------------NDHLYFIFEYMKE-NLYQLMK----------------------DRNK----------------------------------------------------------------------------------------------------LFPESVIRNIMYQILQGLAFIHKH--------GFFHRDMKPENLLCM--G-----PELV----KIADFGLARE------------------LRSQPPY--------------TD---YVSTRWYRAPEVLL-----RSSV---YSSPIDVWAVGSIMAELYM-LR--------------PL---------------FPGT-----------SEVDE-IFKI----CQ----VLG----TPKKSDWPEGYQLASSMNFRFPQCV-PINLKTLIPNASNEAIQ-LMTEMLNWDPKKRPT-----ASQALKHPYF--------------
-------YTNLSYIGEGAYGMVCSAYDN----------------VNKVRVAI-KKI---SPF--E-HQTYC---Q-RT-LR----EIKILLRF--R---HENIIGINDIIR--APT------------------------IEQMKDVYIVQDLMET-DLYKLLK------------------------TQ----------------------------------------------------------------------------------------------------HLSNDHICYFLYQILRGLKYIHSA--------NVLHRDLKPSNLLLN--T-----TCDL----KICDFGLARVAD--------------PDHDHTGFL--------------TE---YVATRWYRAPEIML-----NSKG---YTKSIDIWSVGCILAEMLS-NR--------------PI---------------FPGK-----------HYLDQ-LNHI----LG----ILG----SPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALD-LLDKMLTFNPHKRIE-----VEQALAHPYL--------------
-------YQNLSPVGSGAYGSVCAAFDT----------------KTGLRVAV-KKL---SRP--F-QSIIH---A-KRTYR----ELRLLKHM--K---HENVIGLLDVFT--PARS-----------------------LEEFNDVYLVTHLMGA-DLNNIVK------------------------CQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSA--------DIIHRDLKPSNLAVN--E-----DCEL----KILDFGLAR--------------------HTDDEM--------------TG---YVATRWYRAPEIML-----NWMH---YNQTVDIWSVGCIMAELLT-GR--------------TL---------------FPGT-----------DHIDQ-LKLI----LR----LVG----TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVD-LLEKMLVLDSDKRIT-----AAQALAHAYF--------------
-------YRLQKTIGKGNFAKVKLARHV----------------LTGREVAV-KII---DKT--Q-LNPTS---L-QKLFR----EVRIMKIL--N---HPNIVKLFEVIE--T-----------------------------EKTLYLVMEYASGGEVFDYLV-----------------------AHG----------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVQYCHQK--------YIVHRDLKAENLLLD--G-----DMNI----KIADFGFSNE------------------FTVGNKL--------------DT---FCGSPPYAAPELFQ-----GKKY---DGPEVDVWSLGVILYTLVS-GS--------------LP---------------FDGQ--------------NL-KELR----ER----VLR----GKYRIPFYMS----------------------------TDCEN-LLKKLLVLNPIKRGS-----LEQIMKDRWM--------------
-------YRLLKTIGKGNFAKVKLARHI----------------LTGKEVAV-KII---DKT--Q-LNSSS---L-QKLFR----EVRIMKVL--N---HPNIVKLFEVIE--T-----------------------------EKTLYLVMEYASGGEVFDYLV-----------------------AHG----------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVQYCHQK--------FIVHRDLKAENLLLD--A-----DMNI----KIADFGFSNE------------------FTFGNKL--------------DT---FCGSPPYAAPELFQ-----GKKY---DGPEVDVWSLGVILYTLVS-GS--------------LP---------------FDGQ--------------NL-KELR----ER----VLR----GKYRIPFYMS----------------------------TDCEN-LLKKFLILNPSKRGT-----LEQIMKDRWM--------------
-------YRLLKTIGKGNFAKVKLARHI----------------LTGREVAI-KII---DKT--Q-LNPTS---L-QKLFR----EVRIMKIL--N---HPNIVKLFEVIE--T-----------------------------EKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKV----------------------------------------------------------------------------------------------------QVSFDLLSLMFTFIVSAVQYCHQK--------RIVHRDLKAENLLLD--A-----DMNI----KIADFGFSNE------------------FTVGGKL--------------DT---FCGSPPYAAPELFQ-----GKKY---DGPEVDVWSLGVILYTLVS-GS--------------LP---------------FDGQ--------------NL-KELR----ER----VLR----GKYRIPFYMS----------------------------TDCEN-LLKRFLVLNPIKRGT-----LEQIMKDRWI--------------
-------YRLLRTIGKGNFAKVKLARHI----------------LTGREVAI-KII---DKT--Q-LNPSS---L-QKLFR----EVRIMKGL--N---HPNIVKLFEVIE--T-----------------------------EKTLYLVMEYASAGEVFDYLV-----------------------SHG----------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVHYCHQK--------NIVHRDLKAENLLLD--A-----EANI----KIADFGFSNE------------------FTLGSKL--------------DT---FCGSPPYAAPELFQ-----GKKY---DGPEVDIWSLGVILYTLVS-GS--------------LP---------------FDGH--------------NL-KELR----ER----VLR----GKYRVPFYMS----------------------------TDCES-ILRRFLVLNPAKRCT-----LEQIMKDKWI--------------
-------LTLGAQIGEGEFGAVLQGEYL------------------GQKVAV-KNI---K-C--D-VT-AQ-----AFL-D----ETAVMTKM--Q---HENLVRLLGVIL--------------------------------HQGLYIVMEHVSKGNLVNFLR------------------------TR-------------------------------------------------------------------------------------------------GRALVNTAQLLQFSLHVAEGMEYLESK--------KLVHRDLAARNILVS--E-----DLVA----KVSDFGLAKAE-----------------------R--------------KGLDSSRLPVKWTAPEALK------HGK---FTSKSDVWSFGVLLWEVFSYGR--------------AP---------------YPKM-----------SLKEV-SEAV----EK----GYR----MEPPEGCP------------------------------GPVHV-LMSSCWEAEPARRPP-----FRKLAEKL----------------
-------YRIRGEIGSGNFSQVKLGIHS----------------LTKEKVAI-KIL---DKT--K-LDQKT---Q-RLLSR----EISSMEKL--H---HPNIIRLYEVVE--T-----------------------------LSKLHLVMEYAGGGELFGKIS-----------------------TEG----------------------------------------------------------------------------------------------------KLSEPESKLIFSQIVSAVKHMHEN--------QIIHRDLKAENVFYT--S-----NTCV----KVGDFGFSTV------------------SKKGEML--------------NT---FCGSPPYAAPELFR-----DEHY---IGIYVDIWALGVLLYFMVT-GT--------------MP---------------FRAE--------------TV-AKLK----KS----ILE----GTYSVPPHV----S------------------------EPCHR-LIRGVLQQIPTERYG-----IDCIMNDEWM--------------
------I-EYVRDIGEGAFGRVFQARAPG-----------LLPYEPFTMVAV-KML---K-E--E-AS-ADM-QA-DFQ-R----EAALMAEF--D---NPNIVKLLGVCA--V-----------------------------GKPMCLLFEYMAYGDLNEFLR------------------------SMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSER--------KFVHRDLATRNCLVG--E-----NMVV----KIADFGLSRNI-------------Y---S--ADYY--------------KANENDAIPIRWMPPESIF------YNR---YTTESDVWAYGVVLWEIFSYGL--------------QP---------------YYGM-----------AHEEV-IYYV----RD----GNI----LSCPENCP------------------------------VELYN-LMRLCWSKLPADRPS-----FTSIHRIL----------------
------Y-VRLQKIGEGSFGKAILVKST----------------EDGRQYVI-KEI---NIS--R-MSSKE---R-EESRR----EVAVLANM--K---HPNIVQYRESFE--E-----------------------------NGSLYIVMDYCEGGDLFKRINA---------------------QKGV----------------------------------------------------------------------------------------------------LFQEDQILDWFVQICLALKHVHDR--------KILHRDIKSQNIFLT--K-----DGTV----QLGDFGIARVL-----------------NSTVELA--------------RT---CIGTPYYLSPEICE------NKP---YNNKSDIWALGCVLYELCT-LK--------------HA---------------FEAG--------------SM-KNLV----LK----IIS----GSFPPVSLHYS---------------------------YDLRS-LVSQLFKRNPRDRPS-----VNSILEKGF-I-------------
-------YEVLYTIGTGSYGRCQKIRRK----------------SDGKILVW-KEL---DYG--S-MTEAE---K-QMLVS----EVNLLREL--K---HPNIVRYYDRII--DR---------------------------TNTTLYIVMEYCEGGDLASVITKG-------------------TKERQ----------------------------------------------------------------------------------------------------YLDEEFVLRVMTQLTLALKECHRRSD---GGHTVLHRDLKPANVFLD--G-----KQNV----KLGDFGLARIL-----------------NHDTSFA--------------KT---FVGTPYYMSPEQMN------RMS---YNEKSDIWSLGCLLYELCA-LM--------------PP---------------FTAF--------------SQ-KELA----GK----IRE----GKFRRIPYRY---S------------------------DELNE-IITRMLNLKDYHRPS-----VEEILENPL-I-------------
------Y-CYLRVVGKGSYGEVTLVKHR----------------RDGKQYVI-KKL---NLR--N-ASSRE---R-RAAEQ----EAQLLSQL--K---HPNIVTYKESWE--G----------------------------GDGLLYIVMGFCEGGDLYRKLKE---------------------QKGQ----------------------------------------------------------------------------------------------------LLPENQVVEWFVQIAMALQYLHEK--------HILHRDLKTQNVFLT--R-----TNII----KVGDLGIARVL-----------------ENHCDMA--------------ST---LIGTPYYMSPELFS------NKP---YNYKSDVWALGCCVYEMAT-LK--------------HA---------------FNAK--------------DM-NSLV----YR----IIE----GKLPPMPRDY---S------------------------PELAE-LIRTMLSKRPEERPS-----VRSILRQPYI--------------
-------YDVIKAIGQGAFGKAYLAKGK----------------SDSKHCVI-KEI---NFE--K-MPIQE---K-EASKK----EVILLEKM--K---HPNIVAFFNSFQ--E-----------------------------NGRLFIVMEYCDGGDLMKRINR---------------------QRGV----------------------------------------------------------------------------------------------------LFSEDQILGWFVQISLGLKHIHDR--------KILHRDIKAQNIFLS--K-----NGMV---AKLGDFGIARVL-----------------NNSMELA--------------RT---CIGTPYYLSPEICQ------NKP---YNNKTDIWSLGCVLYELCT-LK--------------HP---------------FEGN--------------NL-QQLV----LK----ICQ----AHFAPISPGF---S------------------------RELHS-LISQLFQVSPRDRPS-----INSILKRPFL--------------
-----IV--LKWELGEGAFGKVFLAECHN-----------LLPEQDKMLVAV-KAL---K-E--A-SE-SA--RQ-DFQ-R----EAELLTML--Q---HQHIVRFFGVCT--E-----------------------------GRPLLMVFEYMRHGDLNRFLR------------------------SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGL--------HFVHRDLATRNCLVG--Q-----GLVV----KIGDFGMSRDI-------------Y---S--TDYY--------------RVGGRTMLPIRWMPPESIL------YRK---FTTESDVWSFGVVLWEIFTYGK--------------QP---------------WYQL-----------SNTEA-IDCI----TQ----GRE----LERPRACP------------------------------PEVYA-IMRGCWQREPQQRHS-----IKDVHARL----------------
------I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKILVAV-KTL---K-D--A-SD-NA--RK-DFH-R----EAELLTNL--Q---HEHIVKFYGVCV--E-----------------------------GDPLIMVFEYMKHGDLNKFLR------------------------AHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQ--------HFVHRDLATRNCLVG--E-----NLLV----KIGDFGMSRDV-------------Y---S--TDYY--------------RVGGHTMLPIRWMPPESIM------YRK---FTTESDVWSLGVVLWEIFTYGK--------------QP---------------WYQL-----------SNNEV-IECI----TQ----GRV----LQRPRTCP------------------------------QEVYE-LMLGCWQREPHMRKN-----IKGIHTL--L--------------
------I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKMLVAV-KAL---K-D--P-TL-AA--RK-DFQ-R----EAELLTNL--Q---HEHIVKFYGVCG--D-----------------------------GDPLIMVFEYMKHGDLNKFLR------------------------AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQ--------HFVHRDLATRNCLVG--A-----NLLV----KIGDFGMSRDV-------------Y---S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM------YRK---FTTESDVWSFGVILWEIFTYGK--------------QP---------------WFQL-----------SNTEV-IECI----TQ----GRV----LERPRVCP------------------------------KEVYD-VMLGCWQREPQQRLN-----IKEIYKIL----------------
-------YELQETLGKGTYGKVKRATER----------------FSGRVVAI-KSI---RKD--K-IKDEQ---D-MVHIR---REIEIMSSL--N---HPHIISIYEVFE--N-----------------------------KDKIVIIMEYASKGELYDYIS-----------------------ERR----------------------------------------------------------------------------------------------------RLSERETRHFFRQIVSAVHYCHKN--------GVVHRDLKLENILLD--D-----NCNI----KIADFGLSNL------------------YQKDKFL--------------QT---FCGSPLYASPEIVN-----GRPY---RGPEVDSWALGVLLYTLVY-GT--------------MP---------------FDGF--------------DH-KNLI----RQ----ISS----GEYREPTQP-----------------------------SDARG-LIRWMLMVNPDRRAT-----IEDIANHWW-V-------------
-------YEFLETLGKGTYGKVKKARES----------------SGR-LVAI-KSI---RKD--K-IKDEQ---D-LMHIR---REIEIMSSL--N---HPHIIAIHEVFE--N-----------------------------SSKIVIVMEYASRGDLYDYIS-----------------------ERQ----------------------------------------------------------------------------------------------------QLSEREARHFFRQIVSAVHYCHQN--------RVVHRDLKLENILLD--A-----NGNI----KIADFGLSNL------------------YHQGKFL--------------QT---FCGSPLYASPEIVN-----GKPY---TGPEVDSWSLGVLLYILVH-GT--------------MP---------------FDGH--------------DH-KILV----KQ----ISN----GAYREPPK-----P------------------------SDACG-LIRWLLMVNPTRRAT-----LEDVASHWW-V-------------
-------YELQEVIGSGATAVVQAAYCA----------------PKKEKVAI-KRI---NLE--K-CQTSM---D-E-LLK----EIQAMSQC--H---HPNIVSYYTSFV--V-----------------------------KDELWLVMKLLSGGSVLDIIKHIVA---------------KGEHKSG----------------------------------------------------------------------------------------------------VLDESTIATILREVLEGLEYLHKN--------GQIHRDVKAGNILLG--E-----DGSV----QIADFGVSAFLAT------------GGDITRNKVR--------------KT---FVGTPCWMAPEVME-----QVRG---YDFKADIWSFGITAIELAT-GA--------------AP---------------YHKY-----------PPMKV-LMLT----LQ----NDP----PSLETGVQDKE--MLK-------------------KYGKSFRK-MISLCLQKDPEKRPT-----AAELLRHKFF--------------
-------YTRYEKIGQGASGTVFTATDV----------------ALGQEVAI-KQI---NLQ--K-QPKKE---L-II--N----EILVMKEL--K---NPNIVNFLDSYL--V-----------------------------GDELFVVMEYLAGGSLTDVVT------------------------ET----------------------------------------------------------------------------------------------------CMDEAQIAAVCRECLQALEFLHAN--------QVIHRDIKSDNVLLG--M-----EGSV----KLTDFGFCAQI-----------------TPEQSKR--------------ST---MVGTPYWMAPEVVT------RKA---YGPKVDIWSLGIMAIEMVE-GE--------------PP---------------YLNE-----------NPLRA-LYLI----AT----NGT----PELQNPEKLS----------------------------PIFRD-FLNRCLEMDVEKRGS-----AKELLQHPFL--------------
---DNFI-----KIGEGSTGIVCIATVR----------------SSGKLVAV-KKM---DLR--K-QQRRE---L---LFN----EVVIMRDY--Q---HENVVEMYNSYL--V-----------------------------GDELWVVMEFLEGGALTDIVT------------------------HT----------------------------------------------------------------------------------------------------RMNEEQIAAVCLAVLQALSVLHAQ--------GVIHRDIKSDSILLT--H-----DGRV----KLSDFGFCAQV-----------------SKEVPRR--------------KS---LVGTPYWMAPELIS------RLP---YGPEVDIWSLGIMVIEMVD-GE--------------PP---------------YFNE-----------PPLKA-MKMI----RD----NLP----PRLKNLHKVS----------------------------PSLKG-FLDRLLVRDPAQRAT-----AAELLKHPFL--------------
---DSYV-----KIGEGSTGIVCLAREK----------------HSGRQVAV-KMM---DLR--K-QQRRE---L---LFN----EVVIMRDY--Q---HFNVVEMYKSYL--V-----------------------------GEELWVLMEFLQGGALTDIVS------------------------QV----------------------------------------------------------------------------------------------------RLNEEQIATVCEAVLQALAYLHAQ--------GVIHRDIKSDSILLT--L-----DGRV----KLSDFGFCAQI-----------------SKDVPKR--------------KS---LVGTPYWMAPEVIS------RSL---YATEVDIWSLGIMVIEMVD-GE--------------PP---------------YFSD-----------SPVQA-MKRL----RD----SPP----PKLKNSHKVS----------------------------PVLRD-FLERMLVRDPQERAT-----AQELLDHPFL--------------
------L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAV-KML---K-P--T-AR-SSE-KQ-ALM-S----ELKIMTHLG-P---HLNIVNLLGACT--K-----------------------------SGPIYIITEYCFYGDLVNYLH------------------------KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASK--------NCVHRDLAARNVLLA--Q-----GKIV----KICDFGLARDI-------------M---H--DSNY--------------VSKGSTFLPVKWMAPESIF------DNL---YTTLSDVWSYGILLWEIFSLGG--------------TP---------------YPGM-M---------VDSTF-YNKI----KS----GYR----MAKPDHAT------------------------------SEVYE-IMVKCWNSEPEKRPS-----FYHLSE---IV-------------
------L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAV-KML---K-S--T-AR-SSE-KQ-ALM-S----ELKIMSHLG-P---HLNVVNLLGACT--K-----------------------------GGPIYIITEYCRYGDLVDYLH------------------------RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASK--------NCVHRDLAARNVLIC--E-----GKLV----KICDFGLARDI-------------M---R--DSNY--------------ISKGSTFLPLKWMAPESIF------NSL---YTTLSDVWSFGILLWEIFTLGG--------------TP---------------YPEL-P---------MNEQF-YNAI----KR----GYR----MAQPAHAS------------------------------DEIYE-IMQKCWEEKFEIRPP-----FSQLVL---LL-------------
------F-KFLAVLGRGHFGKVLLSEFR----------------PSGELFAI-KAL---KKG--D-IVARD---E-VESLM---CEKRILAAV--TSAGHPFLVNLFGCFQ--T-----------------------------PEHVCFVMEYSAGGDLMLHIH------------------------SD----------------------------------------------------------------------------------------------------VFSEPRAIFYSACVVLGLQFLHEH--------KIVYRDLKLDNLLLD--T-----EGYV----KIADFGLCKEG-----------------MGYGDRT--------------ST---FCGTPEFLAPEVLT------DTS---YTRAVDWWGLGVLLYEMLV-GE--------------SP---------------FPGD--------------DE-EEVF----DS----IVN----DEVRYPRFLS----------------------------AEAIG-IMRRLLRRNPERRLGSSERDAEDVKKQPFF--------------
------Y-CRGKVLGKGGFAKCYEMTDL----------------TNNKVYAA-KII---PHS--R-VAKPH---Q-REKID---KEIELHRIL--H---HKHVVQFYHYFE--D-----------------------------KENIYILLEYCSRRSMAHILK-----------------------ARK----------------------------------------------------------------------------------------------------VLTEPEVRYYLRQIVSGLKYLHEQ--------EILHRDLKLGNFFIN--E-----AMEL----KVGDFGLAARL-----------------EPLEHRR--------------RT---ICGTPNYLSPEVLN------KQG---HGCESDIWALGCVMYTMLL-GR--------------PP---------------FETT--------------NL-KETY----RC----IRE----ARYTMPSSLL----------------------------APAKH-LIASMLSKNPEDRPS-----LDDIIRHDFF--------------
-----YL--KGRLLGKGGFARCYEATDT----------------ETGSAYAV-KVI---PQS--R-VAKPH---Q-REKIL---NEIELHRDL--Q---HRHIVRFSHHFE--D-----------------------------ADNIYIFLELCSRKSLAHIWK-----------------------ARH----------------------------------------------------------------------------------------------------TLLEPEVRYYLRQILSGLKYLHQR--------GILHRDLKLGNFFIT--E-----NMEL----KVGDFGLAARL-----------------EPPEQRK--------------KT---ICGTPNYVAPEVLL------RQG---HGPEADVWSLGCVMYTLLC-GS--------------PP---------------FETA--------------DL-KETY----RC----IKQ----VHYTLPASLS----------------------------LPARQ-LLAAILRASPRDRPS-----IDQILRHDFF--------------
------F-NFLMVLGKGSFGKVMLADRK----------------GTEELYAI-KIL---KKD--V-VIQDD---D-VECTM---VEKRVLALL-DK---PPFLTQLHSCFQ--T-----------------------------VDRLYFVMEYVNGGDLMYHIQ-----------------------QVG----------------------------------------------------------------------------------------------------KFKEPQAVFYAAEISIGLFFLHKR--------GIIYRDLKLDNVMLD--S-----EGHI----KIADFGMCKEH-----------------MMDGVTT--------------RT---FCGTPDYIAPEIIA------YQP---YGKSVDWWAYGVLLYEMLA-GQ--------------PP---------------FDGE--------------DE-DELF----QS----IME----HNVSYPKSLS----------------------------KEAVS-VCKGLMTKHPAKRLG-----C---------GPEGERDVREHAFF
------F-NFLMVLGKGSFGKVMLSERK----------------GTDELYAV-KIL---KKD--V-VIQDD---D-VECTM---VEKRVLALP-GK---PPFLTQLHSCFQ--T-----------------------------MDRLYFVMEYVNGGDLMYHIQ-----------------------QVG----------------------------------------------------------------------------------------------------RFKEPHAVFYAAEIAIGLFFLQSK--------GIIYRDLKLDNVMLD--S-----EGHI----KIADFGMCKEN-----------------IWDGVTT--------------KT---FCGTPDYIAPEIIA------YQP---YGKSVDWWAFGVLLYEMLA-GQ--------------AP---------------FEGE--------------DE-DELF----QS----IME----HNVAYPKSMS----------------------------KEAVA-ICKGLMTKHPGKRLG-----C---------GPEGERDIKEHAFF
------V-VLNRILGEGFFGEVYEGVYT-------------NHKGEKINVAV-KTC---K-K--D-CT-LDN-KE-KFM-S----EAVIMKNL--D---HPHIVKLIGIIE--------------------------------EEPTWIIMELYPYGELGHYLE------------------------RN--------------------------------------------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESI--------NCVHRDIAVRNILVA--S-----PECV----KLGDFGLSRYI-----------------E--DEDY--------------YKASVTRLPIKWMSPESIN------FRR---FTTASDVWMFAVCMWEILSFGK--------------QP---------------FFWL-----------ENKDV-IGVL----EK----GDR----LPKPDLCP------------------------------PVLYT-LMTRCWDYDPSDRPR-----FTELVCS--L--------------
------F-TLCRKLGSGYFGEVFEGLWK-----------------DRVQVAI-KVI---S-R--D-NL-LH--QQ-MLQ-S----EIQAMKKL--R---HKHILALYAVVS--V-----------------------------GDPVYIITELMAKGSLLELLR------------------------DS-------------------------------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQ--------NYIHRDLAARNILVG--E-----NTLC----KVGDFGLARLI--------------------KEDV--------------YLSHDHNIPYKWTAPEALS------RGH---YSTKSDVWSFGILLHEMFSRGQ--------------VP---------------YPGM-----------SNHEA-FLRV----DA----GYR----MPCPLECP------------------------------PSVHK-LMLTCWCRDPEQRPC-----FKALRERL----------------
-----VM--LSTRIGSGSFGTVYKGKWH-------------------GDVAV-KIL---K-V-VD-PT-PEQ-FQ-AFR-N----EVAVLRKT--R---HVNILLFMGYMT--------------------------------KDNLAIVTQWCEGSSLYKHLH------------------------VQ--------------------------------------------------------------------------------------------------ETKFQMFQLIDIARQTAQGMDYLHAK--------NIIHRDMKSNNIFLH--E-----GLTV----KIGDFGLATVK-------------S---R--WSGS--------------QQVEQPTGSVLWMAPEVIR------MQDNNPFSFQSDVYSYGIVLYELMT-GE--------------LP---------------YSHI-N---------NRDQI-IFMV----GR----GYASPDLSKLYKNCP------------------------------KAMKR-LVADCVKKVKEERPL-----FPQILSS--I--------------
------L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYTTVAV-KML---K-E--N-AS-PSE-LR-DLL-S----EFNVLKQV--N---HPHVIKLYGACS--Q-----------------------------DGPLLLIVEYAKYGSLRGFLR------------------------ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM--------KLVHRDLAARNILVA--E-----GRKM----KISDFGLSRDV-------------Y---E--EDSY--------------VKRSQGRIPVKWMAIESLF------DHI---YTTQSDVWSFGVLLWEIVTLGG--------------NP---------------YPGI-----------PPERL-FNLL----KT----GHR----MERPDNCS------------------------------EEMYR-LMLQCWKQEPDKRPV-----FADISKDL----------------
-----LT--LRLLLGSGAFGEVYEGTAVDI----------LGVGSGEIKVAV-KTL---K-K--G-ST-DQE-KI-EFL-K----EAHLMSKF--N---HPNILKQLGVCL--L-----------------------------NEPQYIILELMEGGDLLTYLR------------------------KARM--------------------------------------------------------------------------------------------ATFYGPLLTLVDLVDLCVDISKGCVYLERM--------HFIHRDLAARNCLVS--VKDYTSPRIV----KIGDFGLARDI-------------Y---K--NDYY--------------RKRGEGLLPVRWMAPESLM------DGI---FTTQSDVWSFGILIWEILTLGH--------------QP---------------YPAH-----------SNLDV-LNYV----QT----GGR----LEPPRNCP------------------------------DDLWN-LMTQCWAQEPDQRPT-----FHRIQDQL----------------
-------YELVRELGKGTYGKVDLVVYK----------------GTGTKMAL-KFV---NKS--K-TKLKN---F----LR----EVSITNSL-SS---SPFIIKVFDVVF--E----------------------------TEDCYVFAQEYAPAGDLFDIIP-----------------------PQV----------------------------------------------------------------------------------------------------GLPEDTVKRCVQQLGLALDFMHGR--------QLVHRDIKPENVLLFDRE-----CRRV----KLADFGMTR--------------------RVGCRV--------------KR---VSGTIPYTAPEVCQAG-RADGLA---VDTGVDVWAFGVLIFCVLT-GN--------------FP---------------WEAA-----------SGADAFFEEF----VR----WQR----GRLPGLPSQWRRFT------------------------EPALR-MFQRLLALEPERRGP-----AKEVF-----RFLKH---------
-------YDIERTLGKGNFAVVKLARHR----------------VTKTQVAI-KII---DKT--R-LDSSN---L-EKIYR----EVQLMKLL--N---HPHIIKLYQVME--T-----------------------------KDMLYIVTEFAKNGEMFDYLT-----------------------SNG----------------------------------------------------------------------------------------------------HLSENEARKKFWQILSAVEYCHDH--------HIVHRDLKTENLLLD--G-----NMDI----KLADFGFGNF------------------YKSGEPL--------------ST---WCGSPPYAAPEVFE-----GKEY---EGPQLDIWSLGVVLYVLVC-GS--------------LP---------------FDGP--------------NL-PTLR----QR----VLE----GRFRIPFFMS----------------------------QDCES-LIRRMLVVDPARRIT-----IAQIRQHRWM--------------
-------YDIEGTLGKGNFAVVKLGRHR----------------ITKTEVAI-KII---DKS--Q-LDAVN---L-EKIYR----EVQIMKML--D---HPHIIKLYQVME--T-----------------------------KSMLYLVTEYAKNGEIFDYLA-----------------------NHG----------------------------------------------------------------------------------------------------RLNESEARRKFWQILSAVDYCHGR--------KIVHRDLKAENLLLD--N-----NMNI----KIADFGFGNF------------------FKSGELL--------------AT---WCGSPPYAAPEVFE-----GQQY---EGPQLDIWSMGVVLYVLVC-GA--------------LP---------------FDGP--------------TL-PILR----QR----VLE----GRFRIPYFMS----------------------------EDCEH-LIRRMLVLDPSKRLT-----IAQIKEHKWM--------------
-------YDLDKTLGRGHFAVVKLARHV----------------FTGEKVAV-KVI---DKT--K-LDTLA---T-GHLFQ----EVRCMKLV--Q---HPNIVRLYEVID--T-----------------------------QTKLYLILELGDGGDMFDYIM----------------------KHEE----------------------------------------------------------------------------------------------------GLNEDLAKKYFAQIVHAISYCHKL--------HVVHRDLKPENVVFF-EK-----QGLV----KLTDFGFSNK------------------FQPGKKL--------------TT---SCGSLAYSAPEILL-----GDEY---DAPAVDIWSLGVILFMLVC-GQ--------------PP---------------FQEA--------------ND-SETL----TM----IMD----CKYTVPSHVS----------------------------KECKD-LITRMLQRDPKRRAS-----LEEIENHPWL--------------
------L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAI-KTL---K-P--G-TM-SP---E-AFL-Q----EAQVMKKL--R---HEKLVQLYAVVS--------------------------------EEPIYIVTEYMSKGSLLDFLK------------------------GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVG--E-----NLVC----KVADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELTTKGR--------------VP---------------YPGM-----------VNREV-LDQV----ER----GYR----MPCPPECP------------------------------ESLHD-LMCQCWRKEPEERPT-----FEYLQAF--L--------------
-----FA--LGRKLGEGYFGEVWEGLWL-----------------GSLPVAI-KVI---K-S--A-NM-K---LT-DLA-K----EIQTLKGL--R---HERLIRLHAVCS--G-----------------------------GEPVYIVTELMRKGNLQAFLG------------------------TP-------------------------------------------------------------------------------------------------EGRALRLPPLLGFACQVAEGMSYLEEQ--------RVVHRDLAARNVLVD--D-----GLAC----KVADFGLARLL-----------------K--DDIY--------------SPSSSSKIPVKWTAPEAAN------YRV---FSQKSDVWSFGVLLHEVFTYGQ--------------CP---------------YEGM-----------TNHET-LQQI----MR----GYR----LPRPAACP------------------------------AEVYV-LMLECWRSSPEERPS-----FATLREKL----------------
----LCP---GRELGRGKFAVVRKCIKK----------------DSGKEFAA-KFM---RKR--R-KGQDC---R-MEIIH----EIAVLELA-QD---NPWVINLHEVYE--T-----------------------------ASEMILVLEYAAGGEIFDQCVA---------------------DREE----------------------------------------------------------------------------------------------------AFKEKDVQRLMRQILEGVHFLHTR--------DVVHLDLKPQNILLT--S-----ESPLG-DIKIVDFGLSRI------------------LKNSEEL--------------RE---IMGTPEYVAPEILS------YDP---ISMATDMWSIGVLTYVMLT-GI--------------SP---------------FLGN--------------DK-QETF----LN----ISQ----MNLSYSEEEFDVLS------------------------ESAVD-FIRTLLVKKPEDRAT-----AEECLKHPWL--------------
-------FTKLEKIGKGSFGEVFKGIDN----------------RTQKVVAI-KII---DLE--E-AEDEI---E-DIQ-Q----EITVLSQC--D---SPYVTKYYGSYL--K-----------------------------DTKLWIIMEYLGGGSALDLLE------------------------PG----------------------------------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSE--------KKIHRDIKAANVLLS--E-----HGEV----KLADFGVAGQL-----------------TDTQIKR--------------NT---FVGTPFWMAPEVIK------QSA---YDSKADIWSLGITAIELAR-GE--------------PP---------------HSEL-----------HPMKV-LFLI----PK----NNP----PTLEGNYS------------------------------KPLKE-FVEACLNKEPSFRPT-----AKELLKHKFI--------------
-------YELQEVIGSGATAVVQAALCK----------------PRQERVAI-KRI---NLE--K-CQTSM---D-E-LLK----EIQAMSQC--S---HPNVVTYYTSFV--V-----------------------------KDELWLVMKLLSGGSMLDIIKYIVN---------------RGEHKNG----------------------------------------------------------------------------------------------------VLEEAIIATILKEVLEGLDYLHRN--------GQIHRDLKAGNILLG--E-----DGSV----QIADFGVSAFLAT------------GGDVTRNKVR--------------KT---FVGTPCWMAPEVME-----QVRG---YDFKADMWSFGITAIELAT-GA--------------AP---------------YHKY-----------PPMKV-LMLT----LQ----NDP----PTLETGVEDKE--MMK-------------------KYGKSFRK-LLSLCLQKDPSKRPT-----AAELLKCKFF--------------
----TLE---DKELGSGNFGTVKKGYYQ--------------MKKVVKTVAV-KIL---K-N--E-AN-DPALKD-ELL-A----EANVMQQL--D---NPYIVRMIGICE--------------------------------AESWMLVMEMAELGPLNKYLQ------------------------QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEES--------NFVHRDLAARNVLLV--T-----QHYA----KISDFGLSKAL-------------R---A--DENY-------------YKAQTHGKWPVKWYAPECIN------YYK---FSSKSDVWSFGVLMWEAFSYGQ--------------KP---------------YRGM-----------KGSEV-TAML----EK----GER----MGCPAGCP------------------------------REMYD-LMNLCWTYDVENRPG-----FAAVE----LRL------------
-------LTFMRELGSGLFGVVRLGKWR-----------------AQYKVAI-KAI---R-E--G-AM-CE---E-DFI-E----EAKVMMKL--T---HPKLVQLYGVCT--Q-----------------------------QKPIYIVTEFMERGCLLNFLR------------------------QR--------------------------------------------------------------------------------------------------QGHFSRDVLLSMCQDVCEGMEYLERN--------SFIHRDLAARNCLVS--E-----AGVV----KVSDFGMARYV-----------------L--DDQY--------------TSSSGAKFPVKWCPPEVFN------YSR---FSSKSDVWSFGVLMWEVFTEGR--------------MP---------------FEKY-----------TNYEV-VTMV----TR----GHR----LYQPKLAS------------------------------NYVYE-VMLRCWQEKPEGRPS-----FEDLLRT--I--------------
-----IV--LQESIGKGRFGEVWRGKWR----------------GEE--VAV-KIF---SSR--E-ERSWF---R-EA-------EIYQTVML--R---HENILGFIAADN--KDN-------------------------GTWTQLWLVSDYHEHGSLFDYLN------------------------RY----------------------------------------------------------------------------------------------------TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVK--K-----NGTC----CIADLGLAVRHDS-------------ATDTIDIAP--------------NH---RVGTKRYMAPEVLDDSINMKHFE---SFKRADIYAMGLVFWEIAR-RCSIGGI----HEDYQLP---------------YYDLVP------SDPSVEEM-RKVV----CE----QKL----RPNIPNRWQSCEAL------------------------RVMAK-IMRECWYANGAARLT-----ALRIKK----TL------------
----VCR---GELLGSGCFGVVHRGLWT-------------LPSGKSVPVAV-KSLRVGP-E--G-PM-GTE-LG-DFL-R----EVSVMMNL--E---HPHVLRLHGLVL--------------------------------GQPLQMVMELAPLGSLHARLT------------------------AP------------------------------------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGAR--------GLVHRDLATRNLLLA--S-----PRTI----KVADFGLVRPL------------GG---A--RGRY--------------VMGGPRPIPYAWCAPESLR------HGA---FSSASDVWMFGVTLWEMFSGGE--------------EP---------------WAGV-----------PPYLI-LQRL----ED----RAR----LPRPPLCS------------------------------RALYS-LALRCWAPHPADRPS-----FSHLE----GLL------------
------L-RLLEKLGDGSFGVVRRGEWD-------------APSGKTVSVAV-KCL---K-PDVL-SQ-PEA-MD-DFI-R----EVNAMHSL--D---HRNLIRLYGVVL--------------------------------TPPMKMVTELAPLGSLLDRLR------------------------KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK--------RFIHRDLAARNLLLA--T-----RDLV----KIGDFGLMRAL------------PQ---N--DDHY--------------VMQEHRKVPFAWCAPESLK------TRT---FSHASDTWMFGVTLWEMFTYGQ--------------EP---------------WIGL-----------NGSQI-LHKI---DKE----GER----LPRPEDCP------------------------------QDIYN-VMVQCWAHKPEDRPT-----FVALRDF--L--------------
------L-AFIKEIGSGQFGVVHLGEWR-----------------SHIQVAI-KAI---N-E--G-SM-SE---E-DFI-E----EAKVMMKL--S---HSKLVQLYGVCI--Q-----------------------------RKPLYIVTEFMENGCLLNYLR------------------------EN--------------------------------------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLERN--------GYIHRDLAARNCLVS--S-----TCIV----KISDFGMTRYV-----------------L--DDEY--------------VSSFGAKFPIKWSPPEVFL------FNK---YSSKSDVWSFGVLMWEVFTEGK--------------MP---------------FENK-----------SNLQV-VEAI----SE----GFR----LYRPHLAP------------------------------MSIYE-VMYSCWHEKPEGRPT-----FAELLR---AV-------------
------L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAI-KTL---K-P--G-TM-MP---E-AFL-Q----EAQIMKKL--R---HDKLVPLYAVVS--------------------------------EEPIYIVTEFMSKGSLLDFLK------------------------EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERM--------NYIHRDLRAANILVG--E-----NLVC----KIADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILQTELVTKGR--------------VP---------------YPGM-----------VNREV-LEQV----ER----GYR----MPCPQGCP------------------------------ESLHE-LMNLCWKKDPDERPT-----FEYIQSFL----------------
---LIAD----IELGCGNFGSVRQGVYR--------------MRKKQIDVAI-KVL---K-Q--G-TE-KAD-TE-EMM-R----EAQIMHQL--D---NPYIVRLIGVCQ--------------------------------AEALMLVMEMAGGGPLHKFLV------------------------GK--------------------------------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEK--------NFVHRDLAARNVLLV--N-----RHYA----KISDFGLSKAL------------GA---D--DSYY--------------TARSAGKWPLKWYAPECIN------FRK---FSSRSDVWSYGVTMWEALSYGQ--------------KP---------------YKKM-----------KGPEV-MAFI----EQ----GKR----MECPPECP------------------------------PELYA-LMSDCWIYKWEDRPD-----FLTVEQR--M--------------
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