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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK DDR2 203
TK ABL1 261
TK ABL2 288
AGC AKT3 148
TK ALK 1116
TKL ANKK1 25
TK BLK 241
TK BMX 422
TK BTK 402
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK6 13
CMGC CDKL1 5
CMGC CDKL2 4
CAMK DAPK1 13
CAMK DAPK3 13
TK DDR1 572
Other DSTYK 651
TK EGFR 712
TK EPHA8 635
TK ERBB2 720
TK ERBB4 718
TK FER 563
TK FES 561
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FLT4 845
TK FYN 271
TK HCK 241
CMGC ICK 4
TK IGF1R 999
TK INSR 1023
TK INSRR 979
TKL IRAK4 186
TK ITK 363
TK JAK2 849
TK JAK3 822
TK KDR 834
TK KIT 589
TK LCK 245
TKL LRRK2 1886
TK LTK 510
CMGC MAK 4
STE MAP2K1 68
STE MAP2K5 166
TKL MAP3K10 98
TKL MAP3K11 117
TKL MAP3K12 125
TKL MAP3K13 168
TKL MAP3K9 144
TK MUSK 575
Other NEK1 4
Other NEK4 6
Other NEK5 4
Other NEK8 4
Other NEK9 52
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
STE OXSR1 17
STE PAK1 270
STE PAK2 249
STE PAK3 268
STE PAK7 449
TK PDGFRA 593
TK PDGFRB 600
AGC PKN2 657
Other PLK2 82
AGC PRKCD 349
AGC PRKCQ 380
TK PTK6 191
TK RET 724
TK ROS1 1945
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA6 73
TK SRC 270
TK SRMS 230
STE STK24 24
STE STK25 20
AGC STK32A 23
STE STK39 63
TK SYK 371
TK TEC 370
TK TEK 824
TKL TESK1 57
TK TIE1 839
Other TLK2 440
TK TNK1 116
TK TNK2 150
TK TXK 271
TK TYK2 589
TK YES1 277
TK ZAP70 338
-----LTFKEKLGEGQFGEV---HLCEVEGMEKFKDKDFALDVSANQPV---LVAVKML---R-A--DAN-KNA---RN-DFL-K-----EIKIMSRL--K---DPNIIHLLAVCI--T-------DDPLCMITEYMENGDLNQFLS---------RHEPPN-----------------------------------------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSS-L---N---FVHRDLATRNCLVG-K--------NYTI--------KIADFGMSRNL----Y----S--GDYY--------------RIQGRAVLPIRWMSWES--IL----LGK--FTTASDVWAFGVTLWETFTFCQEQP---------------YSQL----SDEQVIENT----GEFFRDQGRQTYLPQPAICP--------------------------------------------DSVYK-LMLSCWRRDTKNRPS-----FQ-EIHL---LL-------------------------------------------------------
-----ITMKHKLGGGQYGEV---YEGVWK----------------KYSL---TVAVKTL---K-E--DTM-EV-----E-EFL-K-----EAAVMKEI--K---HPNLVQLLGVCT--R-------EPPFYIITEFMTYGNLLDYLR---------EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEK-K---N---FIHRDLAARNCLVG-E--------NHLV--------KVADFGLSRLM---------T--GDTY--------------TAHAGAKFPIKWTAPES--LA----YNK--FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI----DLSQVYELL----EK----DYR---MERPEGCP--------------------------------------------EKVYE-LMRACWQWNPSDRPS-----FA-EIHQA--F--------------------------------------------------------
-----ITMKHKLGGGQYGEV---YVGVWK----------------KYSL---TVAVKTL---K-E--DTM-EV-----E-EFL-K-----EAAVMKEI--K---HPNLVQLLGVCT--L-------EPPFYIVTEYMPYGNLLDYLR---------EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEK-K---N---FIHRDLAARNCLVG-E--------NHVV--------KVADFGLSRLM---------T--GDTY--------------TAHAGAKFPIKWTAPES--LA----YNT--FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI----DLSQVYDLL----EK----GYR---MEQPEGCP--------------------------------------------PKVYE-LMRACWKWSPADRPS-----FA-ETHQA--F--------------------------------------------------------
---FD--YLKLLGKGTFGKV---ILVREK----------------ASGK---YYAMKIL---KKE--VIIAKD-----E-VAHTL----TESRVLKNT--R---HPFLTSLKYSFQ--T-------KDRLCFVMEYVNGGELFFHLS--------RER----------------------------------------------------------------------------------------------------VFSEDRTRFYGAEIVSALDYLHS-G---K---IVYRDLKLENLMLD-K--------DGHI--------KITDFGLCKEG---------ITDAATM--------------KT---FCGTPEYLAPEV--LE----DND--YGRAVDWWGLGVVMYEMMC-GR-LP---------------FYNQ-------DHEKLF----EL----ILM---EDIKFPRTLS------------------------------------------SDAKS-LLSGLLIKDPNKRLGGGPDDAK-EIMRHSFF--------------------------------------------------------
----I-TLIRGLGHGAFGEV---YEGQVSG-----------MPNDPSPL---QVAVKTL---P-E--VCS-EQD---EL-DFL-M-----EALIISKF--N---HQNIVRCIGVSL--Q-------SLPRFILLELMAGGDLKSFLR---------ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEE-N---H---FIHRDIAARNCLLT-CP-----GPGRVA--------KIGDFGMARDI----Y----R--ASYY--------------RKGGCAMLPVKWMPPEA--FM----EGI--FTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK----SNQEVLEFV----TS----GGR---MDPPKNCP--------------------------------------------GPVYR-IMTQCWQHQPEDRPN-----FA-IILER--I--------------------------------------------------------
--WRL------VASGGFSQV---FQARHR----------------RWRT---EYAIKCAPCLP-P--DAA-SSD---VN-YLI-E-----EAAKMKKI--K---FQHIVSIYGVCK-----------QPLGIVMEFMANGSLEKVLS---------TH----------------------------------------------------------------------------------------------------SLCWKLRFRIIHETSLAMNFLHS-I---KP-PLLHLDLKPGNILLD-S--------NMHV--------KISDFGLSKWME--QS----T--RMQY--------------IERSALRGMLSYIPPEM--FL----ESNKAPGPKYDVYSFAIVIWELLT-QK-KP---------------YSGF----NMMMIIIRV----AA----GMRPSLQPVSDQWPSEA-----------------------------------------QQMVD-LMKRCWDQDPKKRPC-----FL-DIT----IET------------------------------------------------------
----L-RLVRKLGSGQFGEV---WMGYYK-----------------NNM---KVAIKTL---K-E--GTM-SP-----E-AFL-G-----EANVMKAL--Q---HERLVRLYAVVT----------KEPIYIVTEYMARGCLLDFLK---------TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIER-M---N---SIHRDLRAANILVS-E--------ALCC--------KIADFGLARII------------DSEY--------------TAQEGAKFPIKWTAPEA--IH----FGV--FTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM----SNPEVIRNL----ER----GYR---MPRPDTCP--------------------------------------------PELYRGVIAECWRSRPEERPT-----FE-FLQSV--L--------------------------------------------------------
-----ITLLKELGSGQFGVV---QLGKWK-----------------GQY---DVAVKMI---K-E--GSM-SE-----D-EFF-Q-----EAQTMMKL--S---HPKLVKFYGVCS--K-------EYPIYIVTEYISNGCLLNYLR---------SH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLES-H---Q---FIHRDLAARNCLVD-R--------DLCV--------KVSDFGMTRYV---------L--DDQY--------------VSSVGTKFPVKWSAPEV--FH----YFK--YSSKSDVWAFGILMWEVFSLGK-QP---------------YDLY----DNSQVVLKV----SQ----GHR---LYRPHLAS--------------------------------------------DTIYQ-IMYSCWHELPEKRPT-----FQ-QLLSS--I--------------------------------------------------------
-----LTFLKELGTGQFGVV---KYGKWR-----------------GQY---DVAIKMI---K-E--GSM-SE-----D-EFI-E-----EAKVMMNL--S---HEKLVQLYGVCT--K-------QRPIFIITEYMANGCLLNYLR---------EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLES-K---Q---FLHRDLAARNCLVN-D--------QGVV--------KVSDFGLSRYV---------L--DDEY--------------TSSVGSKFPVRWSPPEV--LM----YSK--FSSKSDIWAFGVLMWEIYSLGK-MP---------------YERF----TNSETAEHI----AQ----GLR---LYRPHLAS--------------------------------------------EKVYT-IMYSCWHEKADERPT-----FK-ILLSN--I--------------------------------------------------------
-----YTKIEKIGEGTYGVV---YKGRHK----------------TTGQ---VVAMKKI---RLE--SEEEGV-----P-STAIR-----EISLLKEL--R---HPNIVSLQDVLM--Q-------DSRLYLIFEFLSM-DLKKYLDS-----IPPGQ----------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHS-R---R---VLHRDLKPQNLLID-D--------KGTI--------KLADFGLARAF---------GIPIRVY--------------TH---EVVTLWYRSPEV--LL---GSAR--YSTPVDIWSIGTIFAELAT-KK-PL---------------FHGD----SEIDQLFRI----FR----ALG---TPNNEVWPEV-ESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-----GK-MALNHPYF--------------------------------------------------------
-----FQKVEKIGEGTYGVV---YKARNK----------------LTGE---VVALKKI---RLD--TETEGV-----P-STAIR-----EISLLKEL--N---HPNIVKLLDVIH--T-------ENKLYLVFEFLHQ-DLKKFMDA------SALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHS-H---R---VLHRDLKPQNLLIN-T--------EGAI--------KLADFGLARAF---------GVPVRTY--------------TH---EVVTLWYRAPEI--LL---GCKY--YSTAVDIWSLGCIFAEMVT-RR-AL---------------FPGD----SEIDQLFRI----FR----TLG---TPDEVVWPGV-TSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-----AK-AALAHPFF--------------------------------------------------------
-----FQKVEKIGEGTYGVV---YKAKNR----------------ETGQ---LVALKKI---RLD--LEMEGV-----P-STAIR-----EISLLKEL--K---HPNIVRLLDVVH--N-------ERKLYLVFEFLSQ-DLKKYMDS------TPGS----------------------------------------------------------------------------------------------------ELPLHLIKSYLFQLLQGVSFCHS-H---R---VIHRDLKPQNLLIN-E--------LGAI--------KLADFGLARAF---------GVPLRTY--------------TH---EVVTLWYRAPEI--LL---GSKF--YTTAVDIWSIGCIFAEMVT-RK-AL---------------FPGD----SEIDQLFRI----FR----MLG---TPSEDTWPGV-TQLPDYKGSFPKWTR---------------KGLEEIVPNLEPEGRD-LLMQLLQYDPSQRIT-----AK-TALAHPYF--------------------------------------------------------
-----YECVAEIGEGAYGKV---FKARDL----------------KNGG--RFVALKRV---RVQ--TGEEGM-----P-LSTIR-----EVAVLRHL--ETFEHPNVVRLFDVCT--VSR--TDRETKLTLVFEHVDQ-DLTTYLDK------VPEP----------------------------------------------------------------------------------------------------GVPTETIKDMMFQLLRGLDFLHS-H---R---VVHRDLKPQNILVT-S--------SGQI--------KLADFGLARI----------YSFQMAL--------------TS---VVVTLWYRAPEV--LL----QSS--YATPVDLWSVGCIFAEMFR-RK-PL---------------FRGS----SDVDQLGKI----LD----VIG---LPGEEDWPRD-VALPRQAFHSKSAQ-----------------PIEKFVTDIDELGKD-LLLKCLTFNPAKRIS-----AY-SALSHPYF--------------------------------------------------------
-----YEKIGKIGEGSYGVV---FKCRNR----------------DTGQ---IVAIKKF---LES--EDDPVI-----K-KIALR-----EIRMLKQL--K---HPNLVNLLEVFR--R-------KRRLHLVFEYCDHTVLHELDR--------YQR----------------------------------------------------------------------------------------------------GVPEHLVKSITWQTLQAVNFCHK-H---N---CIHRDVKPENILIT-K--------HSVI--------KLCDFGFARLL---------AGPSDYY--------------TD---YVATRWYRSPEL--LV---GDTQ--YGPPVDVWAIGCVFAELLS-GV-PL---------------WPGK----SDVDQLYLI----RK----TLG---DLIPRHQQVF-STNQYFSGVKIPDPED-------------MEPLELKFPNISYPALG-LLKGCLHMDPTQRLT-----CE-QLLHHPYF--------------------------------------------------------
-----YENLGLVGEGSYGMV---MKCRNK----------------DTGR---IVAIKKF---LES--DDDKMV-----K-KIAMR-----EIKLLKQL--R---HENLVNLLEVCK--K-------KKRWYLVFEFVDHTILDDLEL--------FPN----------------------------------------------------------------------------------------------------GLDYQVVQKYLFQIINGIGFCHS-H---N---IIHRDIKPENILVS-Q--------SGVV--------KLCDFGFARTL---------AAPGEVY--------------TD---YVATRWYRAPEL--LV---GDVK--YGKAVDVWAIGCLVTEMFM-GE-PL---------------FPGD----SDIDQLYHI----MM----CLG---NLIPRHQELF-NKNPVFAGVRLPEIKE-------------REPLERRYPKLSEVVID-LAKKCLHIDPDKRPF-----CA-ELLHHDFF--------------------------------------------------------
-----YDTGEELGSGQFAVV---KKCREK----------------STGL---QYAAKFI---KKR--RTKSSR-----R-GVSREDI-EREVSILKEI--Q---HPNVITLHEVYE--N-------KTDVILILELVAGGELFDFLA--------EKE----------------------------------------------------------------------------------------------------SLTEEEATEFLKQILNGVYYLHS-L---Q---IAHFDLKPENIMLL-D--------RNVPKP----RIKIIDFGLAHK----------IDFGNEF--------------KN---IFGTPEFVAPEI--VN----YEP--LGLEADMWSIGVITYILLS-GA-SP---------------FLGD-------TKQETL----AN----VSA---VNYEFEDEYF-SNTS-------------------------------------ALAKD-FIRRLLVKDPKKRMT-----IQ-DSLQHPWI--------------------------------------------------------
-----YEMGEELGSGQFAIV---RKCRQK----------------GTGK---EYAAKFI---KKR--RLSSSR-----R-GVSREEI-EREVNILREI--R---HPNIITLHDIFE--N-------KTDVVLILELVSGGELFDFLA--------EKE----------------------------------------------------------------------------------------------------SLTEDEATQFLKQILDGVHYLHS-K---R---IAHFDLKPENIMLL-D--------KNVPNP----RIKLIDFGIAHK----------IEAGNEF--------------KN---IFGTPEFVAPEI--VN----YEP--LGLEADMWSIGVITYILLS-GA-SP---------------FLGE-------TKQETL----TN----ISA---VNYDFDEEYF-SNTS-------------------------------------ELAKD-FIRRLLVKDPKRRMT-----IA-QSLEHSWI--------------------------------------------------------
-----LRFKEKLGEGQFGEV---HLCEVDSPQDLVSLDFPLNVRKGHPL---LVAVKIL---R-P--DAT-KNA---RN-DFL-K-----EVKIMSRL--K---DPNIIRLLGVCV--Q-------DDPLCMITDYMENGDLNQFLS---------AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLAT-L---N---FVHRDLATRNCLVG-E--------NFTI--------KIADFGMSRNL----Y----A--GDYY--------------RVQGRAVLPIRWMAWEC--IL----MGK--FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL----TDEQVIENAGEFFRD----QGRQVYLSRPPACP--------------------------------------------QGLYE-LMLRCWSRESEQRPP-----FS-QLHRFL----------------------------------------------------------
----K--LGQELGRGQYGVV---YLCDNW----------------GGHF---PCALKSV---VPP--DEKHWN-----D---LAL-----EFHYMRSL-PK---HERLVDLHGSVI--DYNYGGGSSIAVLLIMERLHR-DLYTGLK----------A----------------------------------------------------------------------------------------------------GLTLETRLQIALDVVEGIRFLHS-Q---G---LVHRDIKLKNVLLD-K--------QNRA--------KITDLGFCK------------PEAMMS--------------GS---IVGTPIHMAPEL--FT-----GK--YDNSVDVYAFGILFWYICS-GS-VK---------------LPEAF--ERCASKDHLW----NN----VRR---GARPERLPVF----D-------------------------------------EECWQ-LMEACWDGDPLKRP-----------------LLGIVQPML-----------------------------------------------
----F-KKIKVLGSGAFGTV---YKGLWIP------------EGEKVKI---PVAIKEL---R-E--ATS-PKA---NK-EIL-D-----EAYVMASV--D---NPHVCRLLGICL----------TSTVQLITQLMPFGCLLDYVR---------EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLED-R---R---LVHRDLAARNVLVK-T--------PQHV--------KITDFGLAKLL----G----A--EEKE--------------YHAEGGKVPIKWMALES--IL----HRI--YTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI----PASEISSIL----EK----GER---LPQPPICT--------------------------------------------IDVYM-IMVKCWMIDADSRPK-----FR-ELI----IEF------------------------------------------------------
-----IHIEKIIGSGDSGEV---CYGRLR-------------VPGQRDV---PVAIKAL---K-A--GYT-ERQ---RR-DFL-S-----EASIMGQF--D---HPNIIRLEGVVT--R-------GRLAMIVTEYMENGSLDTFLR---------TH--------------------------------------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSD-L---G---YVHRDLAARNVLVD-S--------NLVC--------KVSDFGLSRVL----E----D--DPDA-------------AYTTTGGKIPIRWTAPEA--IA----FRT--FSSASDVWSFGVVMWEVLAYGE-RP---------------YWNM----TNRDVISSV----EE----GYR---LPAPMGCP--------------------------------------------HALHQ-LMLDCWHKDRAQRPR-----FS-QIVSVL----------------------------------------------------------
----L-RKVKVLGSGAFGTV---YKGIWIP------------DGENVKI---PVAIKVL---R-E--NTS-PKA---NK-EIL-D-----EAYVMAGV--G---SPYVSRLLGICL----------TSTVQLVTQLMPYGCLLDHVR---------EN--------------------------------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLED-V---R---LVHRDLAARNVLVK-S--------PNHV--------KITDFGLARLL----D----I--DETE--------------YHADGGKVPIKWMALES--IL----RRR--FTHQSDVWSYGVTVWELMTFGA-KP---------------YDGI----PAREIPDLL----EK----GER---LPQPPICT--------------------------------------------IDVYM-IMVKCWMIDSECRPR-----FR-ELVSE--F--------------------------------------------------------
----L-KRVKVLGSGAFGTV---YKGIWVP------------EGETVKI---PVAIKIL---N-E--TTG-PKA---NV-EFM-D-----EALIMASM--D---HPHLVRLLGVCL----------SPTIQLVTQLMPHGCLLEYVH---------EH--------------------------------------------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEE-R---R---LVHRDLAARNVLVK-S--------PNHV--------KITDFGLARLL----E----G--DEKE--------------YNADGGKMPIKWMALEC--IH----YRK--FTHQSDVWSYGVTIWELMTFGG-KP---------------YDGI----PTREIPDLL----EK----GER---LPQPPICT--------------------------------------------IDVYM-VMVKCWMIDADSRPK-----FK-ELAAE--F--------------------------------------------------------
---VI--LGELLGKGNFGEV---YKGTLK-----------------DKT---SVAVKTC---K-E--DLP-QEL---KI-KFL-Q-----EAKILKQY--D---HPNIVKLIGVCT--Q-------RQPVYIIMELVSGGDFLTFLR---------RK--------------------------------------------------------------------------------------------------KDELKLKQLVKFSLDAAAGMLYLES-K---N---CIHRDLAARNCLVG-E--------NNVL--------KISDFGMSRQE---------D--GGVY--------------SSSGLKQIPIKWTAPEA--LN----YGR--YSSESDVWSFGILLWETFSLGV-CP---------------YPGM----TNQQAREQV----ER----GYR---MSAPQHCP--------------------------------------------EDISK-IMMKCWDYKPENRPK-----FS-ELQKEL----------------------------------------------------------
----L-VLGEQIGRGNFGEV---FSGRLR----------------ADNT---LVAVKSC---R-E--TLP-PDL---KA-KFL-Q-----EARILKQY--S---HPNIVRLIGVCT--Q-------KQPIYIVMELVQGGDFLTFLR---------TE--------------------------------------------------------------------------------------------------GARLRVKTLLQMVGDAAAGMEYLES-K---C---CIHRDLAARNCLVT-E--------KNVL--------KISDFGMSREE----A----D--GVYA--------------ASGGLRQVPVKWTAPEA--LN----YGR--YSSESDVWSFGILLWETFSLGA-SP---------------YPNL----SNQQTREFV----EK----GGR---LPCPELCP--------------------------------------------DAVFR-LMEQCWAYEPGQRPS-----FS-TIYQEL----------------------------------------------------------
-----LTLGKPLGEGCFGQV---VMAEAVGI---------DKDKPKEAV---TVAVKML---K-D--DAT-EKD---LS-DLV-S-----EMEMMKMIG-K---HKNIINLLGACT--Q-------DGPLYVIVEYASKGNLREYLR---------ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS-Q---K---CIHRDLAARNVLVT-E--------NNVM--------KIADFGLARDI----N----N--IDYY--------------KKTTNGRLPVKWMAPEA--LF----DRV--YTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI----PVEELFKLL----KE----GHR---MDKPANCT--------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FK-QLVEDL----------------------------------------------------------
-----LTLGKPLGEGCFGQV---VMAEAIGI---------DKDRAAKPV---TVAVKML---K-D--DAT-DKD---LS-DLV-S-----EMEMMKMIG-K---HKNIINLLGACT--Q-------GGPLYVLVEYAAKGNLREFLR---------ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLAS-Q---K---CIHRDLAARNVLVT-E--------DNVM--------KIADFGLARDV----H----N--LDYY--------------KKTTNGRLPVKWMAPEA--LF----DRV--YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI----PVEELFKLL----KE----GHR---MDKPANCT--------------------------------------------HDLYM-IMRECWHAAPSQRPT-----FK-QLVEDL----------------------------------------------------------
----L-VLGKPLGEGCFGQV---VRAEAFGM---------DPARPDQAS---TVAVKML---K-D--NAS-DKD---LA-DLV-S-----EMEVMKLIG-R---HKNIINLLGVCT--Q-------EGPLYVIVECAAKGNLREFLR---------ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLES-R---K---CIHRDLAARNVLVT-E--------DNVM--------KIADFGLARGV----H----H--IDYY--------------KKTSNGRLPVKWMAPEA--LF----DRV--YTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI----PVEELFSLL----RE----GHR---MDRPPHCP--------------------------------------------PELYG-LMRECWHAAPSQRPT-----FK-QLVEAL----------------------------------------------------------
-----ITLERRLGTGCFGDV---WLGTWN-----------------GST---KVAVKTL---K-P--GTM-SP-----K-AFL-E-----EAQVMKLL--R---HDKLVQLYAVVS----------EEPIYIVTEFMCHGSLLDFLK---------NP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMER-M---N---YIHRDLRAANILVG-E--------RLAC--------KIADFGLARLI---------K--DDEY--------------NPCQGSKFPIKWTAPEA--AL----FGR--FTIKSDVWSFGILLTELITKGR-IP---------------YPGM----NKREVLEQV----EQ----GYH---MPCPPGCP--------------------------------------------ASLYE-AMEQTWRLDPEERPT-----FE-YLQSFL----------------------------------------------------------
-----LHLGRVLGYGAFGKV---VEASAFG-----------IHKGSSCD---TVAVKML---K-E--GAT-ASE---HR-ALM-S-----ELKILIHIG-N---HLNVVNLLGACT-KP-------QGPLMVIVEFCKYGNLSNFLR---------AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLAS-R---K---CIHRDLAARNILLS-E--------SDVV--------KICDFGLARDI----Y----K--DPDY--------------VRKGSARLPLKWMAPES--IF----DKV--YTTQSDVWSFGVLLWEIFSLGA-SP---------------YPGV-Q--INEEFCQRL----RD----GTR---MRAPELAT--------------------------------------------PAIRR-IMLNCWSGDPKARPA-----FS-ELVEIL----------------------------------------------------------
-----LQLIKRLGNGQFGEV---WMGTWN-----------------GNT---KVAIKTL---K-P--GTM-SP-----E-SFL-E-----EAQIMKKL--K---HDKLVQLYAVVS----------EEPIYIVTEYMNKGSLLDFLK---------DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIER-M---N---YIHRDLRSANILVG-N--------GLIC--------KIADFGLARLI---------E--DNEY--------------TARQGAKFPIKWTAPEA--AL----YGR--FTIKSDVWSFGILLTELVTKGR-VP---------------YPGM----NNREVLEQV----ER----GYR---MPCPQDCP--------------------------------------------ISLHE-LMIHCWKKDPEERPT-----FE-YLQSFL----------------------------------------------------------
-----LKLEKKLGAGQFGEV---WMATYN-----------------KHT---KVAVKTM---K-P--GSM-SV-----E-AFL-A-----EANVMKTL--Q---HDKLVKLHAVVT----------KEPIYIITEFMAKGSLLDFLK---------SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQ-R---N---YIHRDLRAANILVS-A--------SLVC--------KIADFGLARVI---------E--DNEY--------------TAREGAKFPIKWTAPEA--IN----FGS--FTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM----SNPEVIRAL----ER----GYR---MPRPENCP--------------------------------------------EELYN-IMMRCWKNRPEERPT-----FE-YIQSV--L--------------------------------------------------------
-----YTTIRQLGDGTYGSV---LLGRSI----------------ESGE---LIAIKKM---KRK--FYSWEE-----C--MNLR-----EVKSLKKL--N---HANVVKLKEVIR--E-------NDHLYFIFEYMKE-NLYQLIK-------ERNK----------------------------------------------------------------------------------------------------LFPESAIRNIMYQILQGLAFIHK-H---G---FFHRDLKPENLLCM-G--------PELV--------KIADFGLARE----------IRSKPPY--------------TD---YVSTRWYRAPEV--LL---RSTN--YSSPIDVWAVGCIMAEVYT-LR-PL---------------FPGA----SEIDTIFKI----CQ----VLG---TPKKTDWPEG-YQLSSAMNFRWPQCV--------------PNNLKTLIPNASSEAVQ-LLRDMLQWDPKKRPT-----AS-QALRYPYF--------------------------------------------------------
-----ITMSRELGQGSFGMV---YEGVAKG-----------VVKDEPET---RVAIKTV---N-E--AAS-MRE---RI-EFL-N-----EASVMKEF--N---CHHVVRLLGVVS--Q-------GQPTLVIMELMTRGDLKSYLR---------SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNA-N---K---FVHRDLAARNCMVA-E--------DFTV--------KIGDFGMTRDI----Y----E--TDYY--------------RKGGKGLLPVRWMSPES--LK----DGV--FTTYSDVWSFGVVLWEIATLAE-QP---------------YQGL----SNEQVLRFV----ME----GGL---LDKPDNCP--------------------------------------------DMLFE-LMRMCWQYNPKMRPS-----FL-EIISS--I--------------------------------------------------------
-----ITLLRELGQGSFGMV---YEGNARD-----------IIKGEAET---RVAVKTV---N-E--SAS-LRE---RI-EFL-N-----EASVMKGF--T---CHHVVRLLGVVS--K-------GQPTLVVMELMAHGDLKSYLR---------SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNA-K---K---FVHRDLAARNCMVA-H--------DFTV--------KIGDFGMTRDI----Y----E--TDYY--------------RKGGKGLLPVRWMAPES--LK----DGV--FTTSSDMWSFGVVLWEITSLAE-QP---------------YQGL----SNEQVLKFV----MD----GGY---LDQPDNCP--------------------------------------------ERVTD-LMRMCWQFNPKMRPT-----FL-EIVNLL----------------------------------------------------------
----I-SIIRELGQGSFGMV---YEGLARG-----------LEAGEEST---PVALKTV---N-E--LAS-PRE---CI-EFL-K-----EASVMKAF--K---CHHVVRLLGVVS--Q-------GQPTLVIMELMTRGDLKSHLR---------SLRPEA-----------------------------------------------------------------------------------------ENNPGLPQPALGEMIQMAGEIADGMAYLAA-N---K---FVHRDLAARNCMVS-Q--------DFTV--------KIGDFGMTRDV----Y----E--TDYY--------------RKGGKGLLPVRWMAPES--LK----DGI--FTTHSDVWSFGVVLWEIVTLAE-QP---------------YQGL----SNEQVLKFV----MD----GGV---LEELEGCP--------------------------------------------LQLQE-LMSRCWQPNPRLRPS-----FT-HILD---SI-------------------------------------------------------
--VGG----NKMGEGGFGVV---YKGYVN----------------NTT-----VAVKKL---AAM--VDITTE-----ELKQQFD----QEIKVMAKC--Q---HENLVELLGFSS--D-------GDDLCLVYVYMPNGSLLDRLSC-----LDGTP----------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHE-N---H---HIHRDIKSANILLD-E--------AFTA--------KISDFGLARASE-------KFAQTVMT--------------SR---IVGTTAYMAPEA--LR-----GE--ITPKSDIYSFGVVLLEIIT-GL-PA---------------VDEH----REPQLLLDI----KE----EIE---DEEKTIEDYI-DKKMNDAD-----------------------------STSVEAMYS-VASQCLHEKKNKRPD-----IK-KVQQ----LLQ-----------------------------------------------------
-----LTFVQEIGSGQFGLV---HLGYWL-----------------NKD---KVAIKTI---R-E--GAM-SE-----E-DFI-E-----EAEVMMKL--S---HPKLVQLYGVCL--E-------QAPICLVFEFMEHGCLSDYLR---------TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEE-A---C---VIHRDLAARNCLVG-E--------NQVI--------KVSDFGMTRFV---------L--DDQY--------------TSSTGTKFPVKWASPEV--FS----FSR--YSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR----SNSEVVEDI----ST----GFR---LYKPRLAS--------------------------------------------THVYQ-IMNHCWKERPEDRPA-----FS-RLLRQL----------------------------------------------------------
-----LKFLQQLGKGNFGSV---EMCRYDP------------LQDNTGE---VVAVKKL---Q-H--STE--EH---LR-DFE-R-----EIEILKSL--Q---HDNIVKYKGVCYSAG-------RRNLKLIMEYLPYGSLRDYLQ---------KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGT-K---R---YIHRDLATRNILVE-N--------ENRV--------KIGDFGLTKVL---PQ----D--KEYY--------------KVKEPGESPIFWYAPES--LT----ESK--FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM----IVFHLIELL----KN----NGR---LPRPDGCP--------------------------------------------DEIYM-IMTECWNNNVNQRPS-----FR-DLA----LRV------------------------------------------------------
----L-KYISQLGKGNFGSV---ELCRYDP------------LGDNTGA---LVAVKQL---Q-H--SGP-DQ----QR-DFQ-R-----EIQILKAL--H---SDFIVKYRGVSYGPG-------RQSLRLVMEYLPSGCLRDFLQ---------RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGS-R---R---CVHRDLAARNILVE-S--------EAHV--------KIADFGLAKLL---PL----D--KDYY--------------VVREPGQSPIFWYAPES--LS----DNI--FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDV-P--ALCRLLELL----EE----GQR---LPAPPACP--------------------------------------------AEVHE-LMKLCWAPSPQDRPS-----FS-ALGP---QL-------------------------------------------------------
-----LKLGKPLGRGAFGQV---IEADAFG-----------IDKTATCR---TVAVKML---K-E--GAT-HSE---HR-ALM-S-----ELKILIHIG-H---HLNVVNLLGACT-KP-------GGPLMVIVEFCKFGNLSTYLR---------SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLAS-R---K---CIHRDLAARNILLS-E--------KNVV--------KICDFGLARDI----Y----K--DPDY--------------VRKGDARLPLKWMAPET--IF----DRV--YTIQSDVWSFGVLLWEIFSLGA-SP---------------YPGV-K--IDEEFCRRL----KE----GTR---MRAPDYTT--------------------------------------------PEMYQ-TMLDCWHGEPSQRPT-----FS-ELVEHL----------------------------------------------------------
-----LSFGKTLGAGAFGKV---VEATAYG-----------LIKSDAAM---TVAVKML---K-P--SAH-LTE---RE-ALM-S-----ELKVLSYLG-N---HMNIVNLLGACT--I-------GGPTLVITEYCCYGDLLNFLR---------RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLAS-K---N---CIHRDLAARNILLT-H--------GRIT--------KICDFGLARDI----K----N--DSNY--------------VVKGNARLPVKWMAPES--IF----NCV--YTFESDVWSYGIFLWELFSLGS-SP---------------YPGM-P--VDSKFYKMI----KE----GFR---MLSPEHAP--------------------------------------------AEMYD-IMKTCWDADPLKRPT-----FK-QIVQL--I--------------------------------------------------------
-----LKLVERLGAGQFGEV---WMGYYN-----------------GHT---KVAVKSL---K-Q--GSM-SP-----D-AFL-A-----EANLMKQL--Q---HQRLVRLYAVVT----------QEPIYIITEYMENGSLVDFLK---------TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEE-R---N---YIHRDLRAANILVS-D--------TLSC--------KIADFGLARLI---------E--DNEY--------------TAREGAKFPIKWTAPEA--IN----YGT--FTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM----TNPEVIQNL----ER----GYR---MVRPDNCP--------------------------------------------EELYQ-LMRLCWKERPEDRPT-----FD-YLRSV--L--------------------------------------------------------
--EFL------LGDGSFGSV---YRAAYE----------------GEE-----VAVKIF---NKH--TSLRLL-----R-Q---------ELVVLCHL--H---HPSLISLLAAGI--R-------P--RMLVMELASKGSLDRLLQ-------QDKA----------------------------------------------------------------------------------------------------SLTRTLQHRIALHVADGLRYLHS-A---M---IIYRDLKPHNVLLF-T--------LY-PNAA--IIAKIADYGIAQ-----------YCCRMGI--------------KT---SEGTPGFRAPEV--AR---GNVI--YNQQADVYSFGLLLYDILTTGG-RI---------------VEGLK-FPNEFDELEIQ----GK----LPD---PVKEYGCAPW------------------------------------------PMVEK-LIKQCLKENPQERPT-----SA-QVF-----DIL-----------------------------------------------------
----V-TLLRALGHGAFGEV---YEGLVIG-----------LPGDSSPL---QVAIKTL---P-E--LCS-PQD---EL-DFL-M-----EALIISKF--R---HQNIVRCVGLSL--R-------ATPRLILLELMSGGDMKSFLR---------HSRP--------------------------------------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEE-N---H---FIHRDIAARNCLLS-CA-----GPSRVA--------KIGDFGMARDI----Y----R--ASYY--------------RRGDRALLPVKWMPPEA--FL----EGI--FTSKTDSWSFGVLLWEIFSLGY-MP---------------YPGR----TNQEVLDFV----VG----GGR---MDPPRGCP--------------------------------------------GPVYR-IMTQCWQHEPELRPS-----FA-SILERL----------------------------------------------------------
-----YTTMRQLGDGTYGSV---LMGKSN----------------ESGE---LVAIKRM---KRK--FYSWDE-----C-M-NLR-----EVKSLKKL--N---HANVIKLKEVIR--E-------NDHLYFIFEYMKE-NLYQLMK-------DRNK----------------------------------------------------------------------------------------------------LFPESVIRNIMYQILQGLAFIHK-H---G---FFHRDMKPENLLCM-G--------PELV--------KIADFGLARE----------LRSQPPY--------------TD---YVSTRWYRAPEV--LL---RSSV--YSSPIDVWAVGSIMAELYM-LR-PL---------------FPGT----SEVDEIFKI----CQ----VLG---TPKKSDWPEG-YQLASSMNFRFPQCV--------------PINLKTLIPNASNEAIQ-LMTEMLNWDPKKRPT-----AS-QALKHPYF--------------------------------------------------------
-----FEKISELGAGNGGVV---FKVSHK----------------PSGL----VMARKL---IHL--EIKPAI-----R-NQIIR-----ELQVLHEC--N---SPYIVGFYGAFY--S-------DGEISICMEHMDGGSLDQVLK--------KAG----------------------------------------------------------------------------------------------------RIPEQILGKVSIAVIKGLTYLREKH---K---IMHRDVKPSNILVN-S--------RGEI--------KLCDFGVSG-----------QLIDSMA--------------NS---FVGTRSYMSPER--LQ----GTH--YSVQSDIWSMGLSLVEMAV-GR-YP---------------IPPP----DAKELELMF----GC----QVE---GDAAETPPRP-RTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQD-FVNKCLIKNPAERAD-----LK-QLMVHAFI--------------------------------------------------------
--IRY---RDTLGHGNGGTV---YKAYHV----------------PSGK---ILAVKVI---LLD--ITLELQ-----K-QI-MS-----ELEILYKC--D---SSYIIGFYGAFF--V-------ENRISICTEFMDGGSLD------------VYR----------------------------------------------------------------------------------------------------KMPEHVLGRIAVAVVKGLTYLWS-L---K---ILHRDVKPSNMLVN-T--------RGQV--------KLCDFGVST-----------QLVNSIA--------------KT---YVGTNAYMAPER--IS----GEQ--YGIHSDVWSLGISFMELAL-GR-FP---------------YPQI----QKNQGSLMP----LQ----LLQ---CIVDEDSPVL-PVGEF-----------------------------------SEPFVH-FITQCMRKQPKERPA-----PE-ELMGHPFI--------------------------------------------------------
-----LQLEEIIGVGGFGKV---YRALWR------------------GE---EVAVKAARLDP-E--KDP-AVT---AE-QVC-Q-----EARLFGAL--Q---HPNIIALRGACL--N-------PPHLCLVMEYARGGALSRVLA---------GR----------------------------------------------------------------------------------------------------RVPPHVLVNWAVQVARGMNYLHN-D---APVPIIHRDLKSINILIL-EAIENHNLADTVL--------KITDFGLAREW--------------HK--------------TTKMSAAGTYAWMAPEV--IR----LSL--FSKSSDVWSFGVLLWELLT-GE-VP---------------YREI----DALAVAYGV---AMN----KLT---LPIPSTCP--------------------------------------------EPFAR-LLEECWDPDPHGRPD-----FG-SILKRL----------------------------------------------------------
-----LRLEEVIGIGGFGKV---YRGSWR------------------GE---LVAVKAA---R-Q--DPD-EDISVTAE-SVR-Q-----EARLFAML--A---HPNIIALKAVCL--E-------EPNLCLVMEYAAGGPLSRALA---------GR----------------------------------------------------------------------------------------------------RVPPHVLVNWAVQIARGMHYLHC-E---ALVPVIHRDLKSNNILLL-QPIESDDMEHKTL--------KITDFGLAREW--------------HK--------------TTQMSAAGTYAWMAPEV--IK----AST--FSKGSDVWSFGVLLWELLT-GE-VP---------------YRGI----DCLAVAYGV---AVN----KLT---LPIPSTCP--------------------------------------------EPFAQ-LMADCWAQDPHRRPD-----FA-SILQQL----------------------------------------------------------
LDLQW------VGSGAQGAV---FLGRFH------------------GE---EVAVKKV---R-D--LKE-T------------------DIKHLRKL--K---HPNIITFKGVCT--Q-------APCYCILMEFCAQGQLYEVLR---------AG---------------------------------------------------------------------------------------------------RPVTPSLLVDWSMGIAGGMNYLHL-H---K---IIHRDLKSPNMLIT-Y--------DDVV--------KISDFGTSKEL-------------SDK--------------STKMSFAGTVAWMAPEV--IR----NEP--VSEKVDIWSFGVVLWELLT-GE-IP---------------YKDV----DSSAIIWGV---GSN----SLH---LPVPSSCP--------------------------------------------DGFKI-LLRQCWNSKPRNRPS-----FR-QILLH--L--------------------------------------------------------
-ISEL----QWLGSGAQGAV---FLGKFR------------------AE---EVAIKKV---R-E--QNE-TD------------------IKHLRKL--K---HPNIIAFKGVCT--Q-------APCYCIIMEYCAHGQLYEVLR---------AG---------------------------------------------------------------------------------------------------RKITPRLLVDWSTGIASGMNYLHL-H---K---IIHRDLKSPNVLVT-H--------TDAV--------KISDFGTSKEL-------------SDK--------------STKMSFAGTVAWMAPEV--IR----NEP--VSEKVDIWSFGVVLWELLT-GE-IP---------------YKDV----DSSAIIWGV---GSN----SLH---LPVPSTCP--------------------------------------------DGFKI-LMKQTWQSKPRNRPS-----FR-QTLMH--L--------------------------------------------------------
----L-TLEEIIGIGGFGKV---YRAFWI----------------GDE-----VAVKAA---RHDP-DEDISQ-----T-IENVR----QEAKLFAML--K---HPNIIALRGVCL--K-------EPNLCLVMEFARGGPLNRVLS---------GK----------------------------------------------------------------------------------------------------RIPPDILVNWAVQIARGMNYLHD-EAIVP---IIHRDLKSSNILIL-Q--------KVENGDLSNKILKITDFGLAR-----------EWHRTTK--------------MS---AAGTYAWMAPEV--IR----ASM--FSKGSDVWSYGVLLWELLT-GE-VP---------------FRGI-------DGLAVA----YG----VAM---NKLALPIPST-CP---------------------------------------EPFAK-LMEDCWNPDPHSRPS-----FT-NILDQ---LT------------------------------------------------------
----I-EYVRDIGEGAFGRV---FQARAPG-----------LLPYEPFT---MVAVKML---K-E--EAS-ADM---QA-DFQ-R-----EAALMAEF--D---NPNIVKLLGVCA--V-------GKPMCLLFEYMAYGDLNEFLR---------SMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSE-R---K---FVHRDLATRNCLVG-E--------NMVV--------KIADFGLSRNI----Y----S--ADYY--------------KANENDAIPIRWMPPES--IF----YNR--YTTESDVWAYGVVLWEIFSYGL-QP---------------YYGM----AHEEVIYYV----RD----GNI---LSCPENCP--------------------------------------------VELYN-LMRLCWSKLPADRPS-----FT-SIHRIL----------------------------------------------------------
----Y-VRLQKIGEGSFGKA---ILVKST----------------EDGR---QYVIKEI---NIS--RMSSKE-----R-EESRR-----EVAVLANM--K---HPNIVQYRESFE--E-------NGSLYIVMDYCEGGDLFKRINA------QKGV----------------------------------------------------------------------------------------------------LFQEDQILDWFVQICLALKHVHD-R---K---ILHRDIKSQNIFLT-K--------DGTV--------QLGDFGIARVL---------NSTVELA--------------RT---CIGTPYYLSPEI--CE----NKP--YNNKSDIWALGCVLYELCT-LK-HA---------------FEAG-------SMKNLV----LK----IIS---GSFPPVSLHY-S----------------------------------------YDLRS-LVSQLFKRNPRDRPS-----VN-SILEKGF-I-------------------------------------------------------
----Y-CYLRVVGKGSYGEV---TLVKHR----------------RDGK---QYVIKKL---NLR--NASSRE-----R-RAAEQ-----EAQLLSQL--K---HPNIVTYKESWE--G------GDGLLYIVMGFCEGGDLYRKLKE------QKGQ----------------------------------------------------------------------------------------------------LLPENQVVEWFVQIAMALQYLHE-K---H---ILHRDLKTQNVFLT-R--------TNII--------KVGDLGIARVL---------ENHCDMA--------------ST---LIGTPYYMSPEL--FS----NKP--YNYKSDVWALGCCVYEMAT-LK-HA---------------FNAK-------DMNSLV----YR----IIE---GKLPPMPRDY----S-------------------------------------PELAE-LIRTMLSKRPEERPS-----VR-SILRQPYI--------------------------------------------------------
-----YDVIKAIGQGAFGKA---YLAKGK----------------SDSK---HCVIKEI---NFE--KMPIQE-----K-EASKK-----EVILLEKM--K---HPNIVAFFNSFQ--E-------NGRLFIVMEYCDGGDLMKRINR------QRGV----------------------------------------------------------------------------------------------------LFSEDQILGWFVQISLGLKHIHD-R---K---ILHRDIKAQNIFLS-K--------NGMV-------AKLGDFGIARVL---------NNSMELA--------------RT---CIGTPYYLSPEI--CQ----NKP--YNNKTDIWSLGCVLYELCT-LK-HP---------------FEGN-------NLQQLV----LK----ICQ---AHFAPISPGF----S-------------------------------------RELHS-LISQLFQVSPRDRPS-----IN-SILKRPFL--------------------------------------------------------
-----YERIRVVGRGAFGIV---HLCLRK----------------ADQK---LVIIKQI---PVE--QMTKEE-----R-QAAQN-----ECQVLKLL--N---HPNVIEYYENFL--E-------DKALMIAMEYAPGGTLAEFIQK------RCNS----------------------------------------------------------------------------------------------------LLEEETILHFFVQILLALHHVHT-H---L---ILHRDLKTQNILLDKH--------RMVV--------KIGDFGISKI----------LSSKSKA--------------YT---VVGTPCYISPEL--CE----GKP--YNQKSDIWALGCVLYELAS-LK-RA---------------FEAA-------NLPALV----LK----IMS---GTFAPISDRY----S-------------------------------------PELRQ-LVLSLLSLEPAQRPP-----LS-HIMAQP--LC------------------------------------------------------
--YIP---IRVLGRGAFGEA---TLYRRT----------------EDDS---LVVWKEV---DLT--RLSEKE-----R-RDALN-----EIVILALL--Q---HDNIIAYYNHFM--D-------NTTLLIELEYCNGGNLYDKILR------QKDK----------------------------------------------------------------------------------------------------LFEEEMVVWYLFQIVSAVSCIHK-A---G---ILHRDIKTLNIFLT-K--------ANLI--------KLGDYGLAKKL---------NSEYSMA--------------ET---LVGTPYYMSPEL--CQ----GVK--YNFKSDIWAVGCVIFELLT-LK-RT---------------FDAT-------NPLNLC----VK----IVQ---GIRAMEVDSS--QYS-------------------------------------LELIQ-MVHSCLDQDPEQRPT-----AD-ELLDRPL-L-------------------------------------------------------
---IV--LKWELGEGAFGKV---FLAECHN-----------LLPEQDKM---LVAVKAL---K-E--ASE-SA----RQ-DFQ-R-----EAELLTML--Q---HQHIVRFFGVCT--E-------GRPLLMVFEYMRHGDLNRFLR---------SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAG-L---H---FVHRDLATRNCLVG-Q--------GLVV--------KIGDFGMSRDI----Y----S--TDYY--------------RVGGRTMLPIRWMPPES--IL----YRK--FTTESDVWSFGVVLWEIFTYGK-QP---------------WYQL----SNTEAIDCI----TQ----GRE---LERPRACP--------------------------------------------PEVYA-IMRGCWQREPQQRHS-----IK-DVHARL----------------------------------------------------------
----I-VLKRELGEGAFGKV---FLAECYN-----------LCPEQDKI---LVAVKTL---K-D--ASD-NA----RK-DFH-R-----EAELLTNL--Q---HEHIVKFYGVCV--E-------GDPLIMVFEYMKHGDLNKFLR---------AHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLAS-Q---H---FVHRDLATRNCLVG-E--------NLLV--------KIGDFGMSRDV----Y----S--TDYY--------------RVGGHTMLPIRWMPPES--IM----YRK--FTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL----SNNEVIECI----TQ----GRV---LQRPRTCP--------------------------------------------QEVYE-LMLGCWQREPHMRKN-----IK-GIHTL--L--------------------------------------------------------
----I-VLKRELGEGAFGKV---FLAECYN-----------LSPTKDKM---LVAVKAL---K-D--PTL-AA----RK-DFQ-R-----EAELLTNL--Q---HEHIVKFYGVCG--D-------GDPLIMVFEYMKHGDLNKFLR---------AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLAS-Q---H---FVHRDLATRNCLVG-A--------NLLV--------KIGDFGMSRDV----Y----S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPES--IM----YRK--FTTESDVWSFGVILWEIFTYGK-QP---------------WFQL----SNTEVIECI----TQ----GRV---LERPRVCP--------------------------------------------KEVYD-VMLGCWQREPQQRLN-----IK-EIYKIL----------------------------------------------------------
-----YELQEVIGSGATAVV---QAAYCA----------------PKKE---KVAIKRI---NLE--KCQTSM-----D-E-LLK-----EIQAMSQC--H---HPNIVSYYTSFV--V-------KDELWLVMKLLSGGSVLDIIKHIVAKGEHKSG----------------------------------------------------------------------------------------------------VLDESTIATILREVLEGLEYLHK-N---G---QIHRDVKAGNILLG-E--------DGSV--------QIADFGVSAFLAT----GGDITRNKVR--------------KT---FVGTPCWMAPEV--ME---QVRG--YDFKADIWSFGITAIELAT-GA-AP---------------YHKY----PPMKVLMLT----LQ----NDP---PSLETGVQDK-E--MLK--------------------------------KYGKSFRK-MISLCLQKDPEKRPT-----AA-ELLRHKFF--------------------------------------------------------
-----YTRFEKIGQGASGTV---YTAMDV----------------ATGQ---EVAIKQM---NLQ--QQPKKE-----L-II--N-----EILVMREN--K---NPNIVNYLDSYL--V-------GDELWVVMEYLAGGSLTDVVT---------ET----------------------------------------------------------------------------------------------------CMDEGQIAAVCRECLQALEFLHS-N---Q---VIHRDIKSDNILLG-M--------DGSV--------KLTDFGFCAQI---------TPEQSKR--------------ST---MVGTPYWMAPEV--VT----RKA--YGPKVDIWSLGIMAIEMIE-GE-PP---------------YLNE----NPLRALYLI----AT----NGT---PELQNPEKLS------------------------------------------AIFRD-FLNRCLEMDVEKRGS-----AK-ELLQHQFL--------------------------------------------------------
-----YTRYEKIGQGASGTV---FTATDV----------------ALGQ---EVAIKQI---NLQ--KQPKKE-----L-II--N-----EILVMKEL--K---NPNIVNFLDSYL--V-------GDELFVVMEYLAGGSLTDVVT---------ET----------------------------------------------------------------------------------------------------CMDEAQIAAVCRECLQALEFLHA-N---Q---VIHRDIKSDNVLLG-M--------EGSV--------KLTDFGFCAQI---------TPEQSKR--------------ST---MVGTPYWMAPEV--VT----RKA--YGPKVDIWSLGIMAIEMVE-GE-PP---------------YLNE----NPLRALYLI----AT----NGT---PELQNPEKLS------------------------------------------PIFRD-FLNRCLEMDVEKRGS-----AK-ELLQHPFL--------------------------------------------------------
-----YTRFEKIGQGASGTV---YTALDI----------------ATGQ---EVAIKQM---NLQ--QQPKKE-----L-II--N-----EILVMREN--K---NPNIVNYLDSYL--V-------GDELWVVMEYLAGGSLTDVVT---------ET----------------------------------------------------------------------------------------------------CMDEGQIAAVCRECLQALDFLHS-N---Q---VIHRDIKSDNILLG-M--------DGSV--------KLTDFGFCAQI---------TPEQSKR--------------ST---MVGTPYWMAPEV--VT----RKA--YGPKVDIWSLGIMAIEMVE-GE-PP---------------YLNE----NPLRALYLI----AT----NGT---PELQNPERLS------------------------------------------AVFRD-FLNRCLEMDVDRRGS-----AK-ELLQHPFL--------------------------------------------------------
-ANFI-----KIGEGSTGIV---CIATEK----------------HTGK---QVAVKKM---DLR--KQQRRE-----L---LFN-----EVVIMRDY--H---HDNVVDMYSSYL--V-------GDELWVVMEFLEGGALTDIVT---------HT----------------------------------------------------------------------------------------------------RMNEEQIATVCLSVLRALSYLHN-Q---G---VIHRDIKSDSILLT-S--------DGRI--------KLSDFGFCAQV---------SKEVPKR--------------KS---LVGTPYWMAPEV--IS----RLP--YGTEVDIWSLGIMVIEMID-GE-PP---------------YFNE----PPLQAMRRI----RD----SLP---PRVKDLHK-----VS-------------------------------------SVLRG-FLDLMLVREPSQRAT-----AQ-ELLGHPFL--------------------------------------------------------
----L-VLGRVLGSGAFGKV---VEGTAYG-----------LSRSQPVM---KVAVKML---K-P--TAR-SSE---KQ-ALM-S-----ELKIMTHLG-P---HLNIVNLLGACT--K-------SGPIYIITEYCFYGDLVNYLH---------KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLAS-K---N---CVHRDLAARNVLLA-Q--------GKIV--------KICDFGLARDI----M----H--DSNY--------------VSKGSTFLPVKWMAPES--IF----DNL--YTTLSDVWSYGILLWEIFSLGG-TP---------------YPGM-M--VDSTFYNKI----KS----GYR---MAKPDHAT--------------------------------------------SEVYE-IMVKCWNSEPEKRPS-----FY-HLSE---IV-------------------------------------------------------
----L-VLGRTLGSGAFGQV---VEATAHG-----------LSHSQATM---KVAVKML---K-S--TAR-SSE---KQ-ALM-S-----ELKIMSHLG-P---HLNVVNLLGACT--K-------GGPIYIITEYCRYGDLVDYLH---------RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLAS-K---N---CVHRDLAARNVLIC-E--------GKLV--------KICDFGLARDI----M----R--DSNY--------------ISKGSTFLPLKWMAPES--IF----NSL--YTTLSDVWSFGILLWEIFTLGG-TP---------------YPEL-P--MNEQFYNAI----KR----GYR---MAQPAHAS--------------------------------------------DEIYE-IMQKCWEEKFEIRPP-----FS-QLVL---LL-------------------------------------------------------
---FR--CCAVLGRGHFGKV---LLAEYK----------------NTNE---MFAIKAL---KKG--DIVARD-----E-VDSLM----CEKRIFETV--NSVRHPFLVNLFACFQ--T-------KEHVCFVMEYAAGGDLMMHIH---------TD----------------------------------------------------------------------------------------------------VFSEPRAVFYAACVVLGLQYLHE-H---K---IVYRDLKLDNLLLD-T--------EGFV--------KIADFGLCKEG---------MGYGDRT--------------ST---FCGTPEFLAPEV--LT----ETS--YTRAVDWWGLGVLIYEMLV-GE-SP---------------FPGD-------DEEEVF----DS----IVN---DEVRYPRFLS------------------------------------------TEAIS-IMRRLLRRNPERRLGASEKDAE-DVKKHPFF--------------------------------------------------------
----Y-CRGKVLGKGGFAKC---YEMTDL----------------TNNK---VYAAKII---PHS--RVAKPH-----Q-REKID----KEIELHRIL--H---HKHVVQFYHYFE--D-------KENIYILLEYCSRRSMAHILK--------ARK----------------------------------------------------------------------------------------------------VLTEPEVRYYLRQIVSGLKYLHE-Q---E---ILHRDLKLGNFFIN-E--------AMEL--------KVGDFGLAARL---------EPLEHRR--------------RT---ICGTPNYLSPEV--LN----KQG--HGCESDIWALGCVMYTMLL-GR-PP---------------FETT-------NLKETY----RC----IRE---ARYTMPSSLL------------------------------------------APAKH-LIASMLSKNPEDRPS-----LD-DIIRHDFF--------------------------------------------------------
---FI--FHKVLGKGSFGKV---LLGELK----------------GRGE---YFAIKAL---KKD--VVLIDD-----D-VECTM----VEKRVLTLA-AE---NPFLTHLICTFQ--T-------KDHLFFVMEFLNGGDLMYHIQ--------DKG----------------------------------------------------------------------------------------------------RFELYRATFYAAEIMCGLQFLHS-K---G---IIYRDLKLDNVLLD-R--------DGHI--------KIADFGMCKEN---------IFGESRA--------------ST---FCGTPDYIAPEI--LQ----GLK--YTFSVDWWSFGVLLYEMLI-GQ-SP---------------FHGD-------DEDELF----ES----IRV---DTPHYPRWIT------------------------------------------KESKD-ILEKLFEREPTKRLG----VTG-NIKIHPFF--------------------------------------------------------
---FI--LHKMLGKGSFGKV---FLAEFK----------------KTNQ---FFAIKAL---KKD--VVLMDD-----D-VECTM----VEKRVLSLA-WE---HPFLTHMFCTFQ--T-------KENLFFVMEYLNGGDLMYHIQ--------SCH----------------------------------------------------------------------------------------------------KFDLSRATFYAAEIILGLQFLHS-K---G---IVYRDLKLDNILLD-K--------DGHI--------KIADFGMCKEN---------MLGDAKT--------------NT---FCGTPDYIAPEI--LL----GQK--YNHSVDWWSFGVLLYEMLI-GQ-SP---------------FHGQ-------DEEELF----HS----IRM---DNPFYPRWLE------------------------------------------KEAKD-LLVKLFVREPEKRLG-----VRGDIRQHPLF--------------------------------------------------------
----F-TLCRKLGSGYFGEV---FEGLWK-----------------DRV---QVAIKVI---S-R--DNL-LH----QQ-MLQ-S-----EIQAMKKL--R---HKHILALYAVVS--V-------GDPVYIITELMAKGSLLELLR---------DS-------------------------------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLES-Q---N---YIHRDLAARNILVG-E--------NTLC--------KVGDFGLARLI------------KEDV--------------YLSHDHNIPYKWTAPEA--LS----RGH--YSTKSDVWSFGILLHEMFSRGQ-VP---------------YPGM----SNHEAFLRV----DA----GYR---MPCPLECP--------------------------------------------PSVHK-LMLTCWCRDPEQRPC-----FK-ALRERL----------------------------------------------------------
----L-VLGKTLGEGEFGKV---VKATAFH-----------LKGRAGYT---TVAVKML---K-E--NAS-PSE---LR-DLL-S-----EFNVLKQV--N---HPHVIKLYGACS--Q-------DGPLLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAE-M---K---LVHRDLAARNILVA-E--------GRKM--------KISDFGLSRDV----Y----E--EDSY--------------VKRSQGRIPVKWMAIES--LF----DHI--YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI----PPERLFNLL----KT----GHR---MERPDNCS--------------------------------------------EEMYR-LMLQCWKQEPDKRPV-----FA-DISKDL----------------------------------------------------------
---LT--LRLLLGSGAFGEV---YEGTAVDI----------LGVGSGEI---KVAVKTL---K-K--GST-DQE---KI-EFL-K-----EAHLMSKF--N---HPNILKQLGVCL--L-------NEPQYIILELMEGGDLLTYLR---------KARM--------------------------------------------------------------------------------------------ATFYGPLLTLVDLVDLCVDISKGCVYLER-M---H---FIHRDLAARNCLVS-VKD---YTSPRIV--------KIGDFGLARDI----Y----K--NDYY--------------RKRGEGLLPVRWMAPES--LM----DGI--FTTQSDVWSFGILIWEILTLGH-QP---------------YPAH----SNLDVLNYV----QT----GGR---LEPPRNCP--------------------------------------------DDLWN-LMTQCWAQEPDQRPT-----FH-RIQDQL----------------------------------------------------------
-----FELLKVLGQGSFGKVFLVRKVTRP----------------DSGH---LYAMKVL---KKA--TLKVRD-----R-VRTKM-----ERDILADV--N---HPFVVKLHYAFQ--T-------EGKLYLILDFLRGGDLFTRLS--------KEV----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALGLDHLHS-L---G---IIYRDLKPENILLD-E--------EGHI--------KLTDFGLSKEA---------IDHEKKA--------------YS---FCGTVEYMAPEV--VN----RQG--HSHSADWWSYGVLMFEMLT-GS-LP---------------FQGK-------DRKETM----TL----ILK---AKLGMPQFLS------------------------------------------TEAQS-LLRALFKRNPANRLGSGPDGAE-EIKRHV--FY------------------------------------------------------
-----FELLKVLGQGSYGKV---FLVRKV----------------KGSDAGQLYAMKVL---KKA--TLKVRD-----R-VRSKM-----ERDILAEV--N---HPFIVKLHYAFQ--T-------EGKLYLILDFLRGGDLFTRLS--------KEV----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHS-L---G---IIYRDLKPENILLD-E--------EGHI--------KITDFGLSKEA---------IDHDKRA--------------YS---FCGTIEYMAPEV--VN----RRG--HTQSADWWSFGVLMFEMLT-GS-LP---------------FQGK-------DRKETM----AL----ILK---AKLGMPQFLS------------------------------------------GEAQS-LLRALFKRNPCNRLGAGIDGVE-EIKRHPFF--------------------------------------------------------
-----FELLKVLGQGSFGKV---FLVKKI----------------SGSDARQLYAMKVL---KKA--TLKVRD-----R-VRTKM-----ERDILVEV--N---HPFIVKLHYAFQ--T-------EGKLYLILDFLRGGDLFTRLS--------KEV----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHS-L---G---IIYRDLKPENILLD-E--------EGHI--------KLTDFGLSKES---------IDHEKKA--------------YS---FCGTVEYMAPEV--VN----RRG--HTQSADWWSFGVLMFEMLT-GT-LP---------------FQGK-------DRKETM----TM----ILK---AKLGMPQFLS------------------------------------------PEAQS-LLRMLFKRNPANRLGAGPDGVE-EIKRHSFF--------------------------------------------------------
-----FELLKVLGQGSFGKV---FLVRKK----------------TGPDAGQLYAMKVL---KKA--SLKVRD-----R-VRTKM-----ERDILVEV--N---HPFIVKLHYAFQ--T-------EGKLYLILDFLRGGDVFTRLS--------KEV----------------------------------------------------------------------------------------------------LFTEEDVKFYLAELALALDHLHQ-L---G---IVYRDLKPENILLD-E--------IGHI--------KLTDFGLSKES---------VDQEKKA--------------YS---FCGTVEYMAPEV--VN----RRG--HSQSADWWSYGVLMFEMLT-GT-LP---------------FQGK-------DRNETM----NM----ILK---AKLGMPQFLS------------------------------------------AEAQS-LLRMLFKRNPANRLGS--EGVE-EIKRHLFF--------------------------------------------------------
----L-RLEVKLGQGCFGEV---WMGTWN-----------------GTT---RVAIKTL---K-P--GTM-SP-----E-AFL-Q-----EAQVMKKL--R---HEKLVQLYAVVS----------EEPIYIVTEYMSKGSLLDFLK---------GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVER-M---N---YVHRDLRAANILVG-E--------NLVC--------KVADFGLARLI---------E--DNEY--------------TARQGAKFPIKWTAPEA--AL----YGR--FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM----VNREVLDQV----ER----GYR---MPCPPECP--------------------------------------------ESLHD-LMCQCWRKEPEERPT-----FE-YLQAF--L--------------------------------------------------------
---FA--LGRKLGEGYFGEV---WEGLWL-----------------GSL---PVAIKVI---K-S--ANM-K-----LT-DLA-K-----EIQTLKGL--R---HERLIRLHAVCS--G-------GEPVYIVTELMRKGNLQAFLG---------TP-------------------------------------------------------------------------------------------------EGRALRLPPLLGFACQVAEGMSYLEE-Q---R---VVHRDLAARNVLVD-D--------GLAC--------KVADFGLARLL---------K--DDIY--------------SPSSSSKIPVKWTAPEA--AN----YRV--FSQKSDVWSFGVLLHEVFTYGQ-CP---------------YEGM----TNHETLQQI----MR----GYR---LPRPAACP--------------------------------------------AEVYV-LMLECWRSSPEERPS-----FA-TLREKL----------------------------------------------------------
-----FTKLEKIGKGSFGEV---FKGIDN----------------RTQK---VVAIKII---DLE--EAEDEI-----E-DIQ-Q-----EITVLSQC--D---SPYVTKYYGSYL--K-------DTKLWIIMEYLGGGSALDLLE---------PG----------------------------------------------------------------------------------------------------PLDETQIATILREILKGLDYLHS-E---K---KIHRDIKAANVLLS-E--------HGEV--------KLADFGVAGQL---------TDTQIKR--------------NT---FVGTPFWMAPEV--IK----QSA--YDSKADIWSLGITAIELAR-GE-PP---------------HSEL----HPMKVLFLI----PK----NNP---PTLEGNYS--------------------------------------------KPLKE-FVEACLNKEPSFRPT-----AK-ELLKHKFI--------------------------------------------------------
----F-TKLDRIGKGSFGEV---YKGIDN----------------HTKE---VVAIKII---DLE--EAEDEI-----E-DIQ-Q-----EITVLSQC--D---SPYITRYFGSYL--K-------STKLWIIMEYLGGGSALDLLK---------PG----------------------------------------------------------------------------------------------------PLEETYIATILREILKGLDYLHS-E---R---KIHRDIKAANVLLS-E--------QGDV--------KLADFGVAGQL---------TDTQIKR--------------NT---FVGTPFWMAPEV--IK----QSA--YDFKADIWSLGITAIELAK-GE-PP---------------NSDL----HPMRVLFLI----PK----NSP---PTLEGQHS--------------------------------------------KPFKE-FVEACLNKDPRFRPT-----AK-ELLKHKFI--------------------------------------------------------
-----FEILRAIGKGSFGKV---CIVQKN----------------DTKK---MYAMKYM---NKQ--KCVERN-----E-VRNVF----KELQIMQGL--E---HPFLVNLWYSFQ--D-------EEDMFMVVDLLLGGDLRYHLQ--------QNV----------------------------------------------------------------------------------------------------HFKEETVKLFICELVMALDYLQN-Q---R---IIHRDMKPDNILLD-E--------HGHV--------HITDFNIAAM----------LPRETQI--------------TT---MAGTKPYMAPEMFSSR---KGAG--YSFAVDWWSLGVTAYELLR-GR-RP---------------YHIR----SSTSSKEIV----HT----FET---TVVTYPSAWS------------------------------------------QEMVS-LLKKLLEPNPDQRFS----QLS-DVQNFPY-M-------------------------------------------------------
-----YELQEVIGSGATAVV---QAALCK----------------PRQE---RVAIKRI---NLE--KCQTSM-----D-E-LLK-----EIQAMSQC--S---HPNVVTYYTSFV--V-------KDELWLVMKLLSGGSMLDIIKYIVNRGEHKNG----------------------------------------------------------------------------------------------------VLEEAIIATILKEVLEGLDYLHR-N---G---QIHRDLKAGNILLG-E--------DGSV--------QIADFGVSAFLAT----GGDVTRNKVR--------------KT---FVGTPCWMAPEV--ME---QVRG--YDFKADMWSFGITAIELAT-GA-AP---------------YHKY----PPMKVLMLT----LQ----NDP---PTLETGVEDK-E--MMK--------------------------------KYGKSFRK-LLSLCLQKDPSKRPT-----AA-ELLKCKFF--------------------------------------------------------
--TLE---DKELGSGNFGTV---KKGYYQ--------------MKKVVK---TVAVKIL---K-N--EAN-DPA--LKD-ELL-A-----EANVMQQL--D---NPYIVRMIGICE----------AESWMLVMEMAELGPLNKYLQ---------QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEE-S---N---FVHRDLAARNVLLV-T--------QHYA--------KISDFGLSKAL----R----A--DENY-------------YKAQTHGKWPVKWYAPEC--IN----YYK--FSSKSDVWSFGVLMWEAFSYGQ-KP---------------YRGM----KGSEVTAML----EK----GER---MGCPAGCP--------------------------------------------REMYD-LMNLCWTYDVENRPG-----FA-AVE----LRL------------------------------------------------------
-----LTFMRELGSGLFGVV---RLGKWR-----------------AQY---KVAIKAI---R-E--GAM-CE-----E-DFI-E-----EAKVMMKL--T---HPKLVQLYGVCT--Q-------QKPIYIVTEFMERGCLLNFLR---------QR--------------------------------------------------------------------------------------------------QGHFSRDVLLSMCQDVCEGMEYLER-N---S---FIHRDLAARNCLVS-E--------AGVV--------KVSDFGMARYV---------L--DDQY--------------TSSSGAKFPVKWCPPEV--FN----YSR--FSSKSDVWSFGVLMWEVFTEGR-MP---------------FEKY----TNYEVVTMV----TR----GHR---LYQPKLAS--------------------------------------------NYVYE-VMLRCWQEKPEGRPS-----FE-DLLRT--I--------------------------------------------------------
-----IKFQDVIGEGNFGQV---LKARIK--------------KDGLRM---DAAIKRM---K-E--YAS-KDD---HR-DFA-G-----ELEVLCKLG-H---HPNIINLLGACE--H-------RGYLYLAIEYAPHGNLLDFLR---------KSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQ-K---Q---FIHRDLAARNILVG-E--------NYVA--------KIADFGLSRGQ-------------EVY--------------VKKTMGRLPVRWMAIES--LN----YSV--YTTNSDVWSYGVLLWEIVSLGG-TP---------------YCGM----TCAELYEKL----PQ----GYR---LEKPLNCD--------------------------------------------DEVYD-LMRQCWREKPYERPS-----FA-QILV---SL-------------------------------------------------------
----F-HCAEKIGAGFFSEV---YKVRHR----------------QSGQ---VMVLKMN---KLP--SNRGNT----------LR-----EVQLMNRL--R---HPNILRFMGVCV--H-------QGQLHALTEYMNGGTLEQLLS--------SPE----------------------------------------------------------------------------------------------------PLSWPVRLHLALDIARGLRYLHS-K---G---VFHRDLTSKNCLVR-R--------EDRGF-----TAVVGDFGLAEKIPV-----YREGARKEP--------------LA---VVGSPYWMAPEV--LR----GEL--YDEKADVFAFGIVLCELIA-R--VP-----------------------------------------------------------------------------------------------------------------------------------------ADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHL
-----ITFEDLIGEGNFGQV---IRAMIK--------------KDGLKM---NAAIKML---K-E--YAS-END---HR-DFA-G-----ELEVLCKLG-H---HPNIINLLGACK--N-------RGYLYIAIEYAPYGNLLDFLR---------KSRVLETDP-----------------------------------------------------------------------------------AFAREHGTASTLSSRQLLRFASDAANGMQYLSE-K---Q---FIHRDLAARNVLVG-E--------NLAS--------KIADFGLSRGE-------------EVY--------------VKKTMGRLPVRWMAIES--LN----YSV--YTTKSDVWSFGVLLWEIVSLGG-TP---------------YCGM----TCAELYEKL----PQ----GYR---MEQPRNCD--------------------------------------------DEVYE-LMRQCWRDRPYERPP-----FA-QIALQ--L--------------------------------------------------------
---YL--LLHLLGRGGFSEV---YKAFDL----------------TEQR---YVAVKIH---QLN--KNWRDE-----K-KENYHKHACREYRIHKEL--D---HPRIVKLYDYFS--L------DTDSFCTVLEYCEGNDLDFYLK--------QHK----------------------------------------------------------------------------------------------------LMSEKEARSIIMQIVNALKYLNE-IK-PP---IIHYDLKPGNILLV-N--------GTACG-----EIKITDFGLSKIMDDD--SYNSVDGMELT--------------SQ---GAGTYWYLPPEC--FVVGKEPPK--ISNKVDVWSVGVIFYQCLY-GR-KP---------------FGHN-----QSQQDILQ----EN----TIL---KATEVQFPPK-PVVT-------------------------------------PEAKA-FIRRCLAYRKEDRID-----VQ-QLACDPYL--------------------------------------------------------
--VCR---GELLGSGCFGVV---HRGLWT-------------LPSGKSV---PVAVKSLRVGP-E--GPM-GTE---LG-DFL-R-----EVSVMMNL--E---HPHVLRLHGLVL----------GQPLQMVMELAPLGSLHARLT---------AP------------------------------------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGA-R---G---LVHRDLATRNLLLA-S--------PRTI--------KVADFGLVRPL---GG----A--RGRY--------------VMGGPRPIPYAWCAPES--LR----HGA--FSSASDVWMFGVTLWEMFSGGE-EP---------------WAGV----PPYLILQRL----ED----RAR---LPRPPLCS--------------------------------------------RALYS-LALRCWAPHPADRPS-----FS-HLE----GLL------------------------------------------------------
----L-RLLEKLGDGSFGVV---RRGEWD-------------APSGKTV---SVAVKCL---K-PDVLSQ-PEA---MD-DFI-R-----EVNAMHSL--D---HRNLIRLYGVVL----------TPPMKMVTELAPLGSLLDRLR---------KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLES-K---R---FIHRDLAARNLLLA-T--------RDLV--------KIGDFGLMRAL---PQ----N--DDHY--------------VMQEHRKVPFAWCAPES--LK----TRT--FSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL----NGSQILHKI---DKE----GER---LPRPEDCP--------------------------------------------QDIYN-VMVQCWAHKPEDRPT-----FV-ALRDF--L--------------------------------------------------------
----L-AFIKEIGSGQFGVV---HLGEWR-----------------SHI---QVAIKAI---N-E--GSM-SE-----E-DFI-E-----EAKVMMKL--S---HSKLVQLYGVCI--Q-------RKPLYIVTEFMENGCLLNYLR---------EN--------------------------------------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLER-N---G---YIHRDLAARNCLVS-S--------TCIV--------KISDFGMTRYV---------L--DDEY--------------VSSFGAKFPIKWSPPEV--FL----FNK--YSSKSDVWSFGVLMWEVFTEGK-MP---------------FENK----SNLQVVEAI----SE----GFR---LYRPHLAP--------------------------------------------MSIYE-VMYSCWHEKPEGRPT-----FA-ELLR---AV-------------------------------------------------------
----L-KKIRDLGEGHFGKV---SLYCYDP------------TNDGTGE---MVAVKAL---K-A--DCG-PQH---RS-GWK-Q-----EIDILRTL--Y---HEHIIKYKGCCEDQG-------EKSLQLVMEYVPLGSLRDYLP---------RH----------------------------------------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHA-Q---H---YIHRDLAARNVLLD-N--------DRLV--------KIGDFGLAKAV---PE----G--HEYY--------------RVREDGDSPVFWYAPEC--LK----EYK--FYYASDVWSFGVTLYELLTHCD-SSQSPPTKF-LELIGIAQGQM----TVLRLTELL----ER----GER---LPRPDKCP--------------------------------------------CEVYH-LMKNCWETEASFRPT-----FE-NLIP---IL-------------------------------------------------------
----L-RLEVKLGQGCFGEV---WMGTWN-----------------GTT---KVAIKTL---K-P--GTM-MP-----E-AFL-Q-----EAQIMKKL--R---HDKLVPLYAVVS----------EEPIYIVTEFMSKGSLLDFLK---------EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIER-M---N---YIHRDLRAANILVG-E--------NLVC--------KIADFGLARLI---------E--DNEY--------------TARQGAKFPIKWTAPEA--AL----YGR--FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM----VNREVLEQV----ER----GYR---MPCPQGCP--------------------------------------------ESLHE-LMNLCWKKDPDERPT-----FE-YIQSFL----------------------------------------------------------
-LIAD----IELGCGNFGSV---RQGVYR--------------MRKKQI---DVAIKVL---K-Q--GTE-KAD---TE-EMM-R-----EAQIMHQL--D---NPYIVRLIGVCQ----------AEALMLVMEMAGGGPLHKFLV---------GK--------------------------------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEE-K---N---FVHRDLAARNVLLV-N--------RHYA--------KISDFGLSKAL---GA----D--DSYY--------------TARSAGKWPLKWYAPEC--IN----FRK--FSSRSDVWSYGVTMWEALSYGQ-KP---------------YKKM----KGPEVMAFI----EQ----GKR---MECPPECP--------------------------------------------PELYA-LMSDCWIYKWEDRPD-----FL-TVEQR--M--------------------------------------------------------
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