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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK DDR2 203
TK ABL1 261
TK ABL2 288
TK BLK 241
TKL BRAF 456
CMGC CDC2 4
CMGC CDK2 4
TK CSF1R 582
TK DDR1 572
TK EGFR 712
TK EPHA3 621
TK EPHA8 635
TK ERBB2 720
TK ERBB4 718
TK FGFR1 478
TK FGR 263
TK FRK 234
TK FYN 271
TK HCK 241
TK IGF1R 999
TK INSR 1023
TKL IRAK1 212
TK ITK 363
TK JAK2 849
TK JAK3 822
TK KIT 589
TK LCK 245
TK LYN 247
CMGC MAPK14 24
TK NTRK1 510
TK PDGFRA 593
TK PDGFRB 600
AGC PRKCA 339
AGC PRKCD 349
AGC PRKCQ 380
TKL RAF1 349
TK RET 724
TK SRC 270
TK SYK 371
TKL TGFBR1 205
TK TYK2 589
TK YES1 277
----LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR-A-DAN-KNA-RNDFL-K--EIKIMSRL--KDPNIIHLLAVCI--T------DDPLCMITEYMENGDLNQFLS-----RHEPPN-----------------------------------------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSSL--------NFVHRDLATRNCLVGKNYTIKIADFGMSRNL-----Y-----S--GDYY-RIQGRAVLPIRWMSWESIL------LGK---FTTASDVWAFGVTLWETFTFCQE---------QP---------------YSQL-----SDEQVIENT----GEFFRDQGRQ-TYLPQPAICP-------------------------------------------DSVYK-LMLSCWRRDTKNRPS-FQ-EIHL---LL-------------
----ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTLK-E-DTM-EV---EEFL-K--EAAVMKEI--KHPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR-----EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGENHLVKVADFGLSRLM-----------T--GDTY-TAHAGAKFPIKWTAPESLA------YNK---FSIKSDVWAFGVLLWEIATYGM----------SP---------------YPGI-----DLSQVYELL----EK----DYR----MERPEGCP-------------------------------------------EKVYE-LMRACWQWNPSDRPS-FA-EIHQA--F--------------
----ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTLK-E-DTM-EV---EEFL-K--EAAVMKEI--KHPNLVQLLGVCT--L------EPPFYIVTEYMPYGNLLDYLR-----EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGENHVVKVADFGLSRLM-----------T--GDTY-TAHAGAKFPIKWTAPESLA------YNT---FSIKSDVWAFGVLLWEIATYGM----------SP---------------YPGI-----DLSQVYDLL----EK----GYR----MEQPEGCP-------------------------------------------PKVYE-LMRACWKWSPADRPS-FA-ETHQA--F--------------
---L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAIKTLK-E-GTM-SP---EAFL-G--EANVMKAL--QHERLVRLYAVVT---------KEPIYIVTEYMARGCLLDFLK-----TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERM--------NSIHRDLRAANILVSEALCCKIADFGLARII--------------DSEY-TAQEGAKFPIKWTAPEAIH------FGV---FTIKADVWSFGVLLMEVVTYGR----------VP---------------YPGM-----SNPEVIRNL----ER----GYR----MPRPDTCP-------------------------------------------PELYRGVIAECWRSRPEERPT-FE-FLQSV--L--------------
----ITVGQRIGSGSFGTVYKGKWH-------------------GDVAVKMLN-VTAPT-PQQ-LQAFK-N--EVGVLRKT--RHVNILLFMGYST---------KPQLAIVTQWCEGSSLYHHLH-----II--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAK--------SIIHRDLKSNNIFLHEDLTVKIGDFGLATVK-----S-----R--WSGS-HQFEQLSGSILWMAPEVIR------MQDKNPYSFQSDVYAFGIVLYELMT-GQ----------LP---------------YSNI-N---NRDQIIFMV----GR----GYLSPDLSKVRSNCP-------------------------------------------KAMKR-LMAECLKKKRDERPL-FP-QILA---SI-------------
----YTKIEKIGEGTYGVVYKGRHK----------------TTGQVVAMKKIRLE-SEEEGV---PSTAIR--EISLLKEL--RHPNIVSLQDVLM--Q------DSRLYLIFEFLSM-DLKKYLDS-IPPGQ----------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSR--------RVLHRDLKPQNLLIDDKGTIKLADFGLARAF-----------GIPIRVY-TH---EVVTLWYRSPEVLL-----GSAR---YSTPVDIWSIGTIFAELAT-KK----------PL---------------FHGD-----SEIDQLFRI----FR----ALG----TPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-GK-MALNHPYF--------------
----FQKVEKIGEGTYGVVYKARNK----------------LTGEVVALKKIRLD-TETEGV---PSTAIR--EISLLKEL--NHPNIVKLLDVIH--T------ENKLYLVFEFLHQ-DLKKFMDA--SALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH--------RVLHRDLKPQNLLINTEGAIKLADFGLARAF-----------GVPVRTY-TH---EVVTLWYRAPEILL-----GCKY---YSTAVDIWSLGCIFAEMVT-RR----------AL---------------FPGD-----SEIDQLFRI----FR----TLG----TPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-AK-AALAHPFF--------------
----LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAVKMLK-S-TAH-ADE-KEALM-S--ELKIMSHLG-QHENIVNLLGACT--H------GGPVLVITEYCCYGDLLNFLR-----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASK--------NCIHRDVAARNVLLTNGHVAKIGDFGLARDI-----M-----N--DSNY-IVKGNARLPVKWMAPESIF------DCV---YTVQSDVWSYGILLWEIFSLGL----------NP---------------YPGI-L---VNSKFYKLV----KD----GYQ----MAQPAFAP-------------------------------------------KNIYS-IMQACWALEPTHRPT-FQ-QICSFL----------------
----LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR-P-DAT-KNA-RNDFL-K--EVKIMSRL--KDPNIIRLLGVCV--Q------DDPLCMITDYMENGDLNQFLS-----AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATL--------NFVHRDLATRNCLVGENFTIKIADFGMSRNL-----Y-----A--GDYY-RVQGRAVLPIRWMAWECIL------MGK---FTTASDVWAFGVTLWEVLMLCRA---------QP---------------FGQL-----TDEQVIENAGEFFRD----QGRQ-VYLSRPPACP-------------------------------------------QGLYE-LMLRCWSRESEQRPP-FS-QLHRFL----------------
---F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKIPVAIKELR-E-ATS-PKA-NKEIL-D--EAYVMASV--DNPHVCRLLGICL---------TSTVQLITQLMPFGCLLDYVR-----EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR--------RLVHRDLAARNVLVKTPQHVKITDFGLAKLL-----G-----A--EEKE-YHAEGGKVPIKWMALESIL------HRI---YTHQSDVWSYGVTVWELMTFGS----------KP---------------YDGI-----PASEISSIL----EK----GER----LPQPPICT-------------------------------------------IDVYM-IMVKCWMIDADSRPK-FR-ELI----IEF------------
---I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEISVAIKTLK-V-GYT-EKQ-RRDFL-G--EASIMGQF--DHPNIIRLEGVVT--K------SKPVMIVTEYMENGSLDSFLR-----KH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDM--------GYVHRDLAARNILINSNLVCKVSDFGLSRVL-----E-----D--DPEAAYTTRGGKIPIRWTSPEAIA------YRK---FTSASDVWSYGIVLWEVMSYGE----------RP---------------YWEM-----SNQDVIKAV----DE----GYR----LPPPMDCP-------------------------------------------AALYQ-LMLDCWQKDRNNRPK-FE-QIVSIL----------------
----IHIEKIIGSGDSGEVCYGRLR-------------VPGQRDVPVAIKALK-A-GYT-ERQ-RRDFL-S--EASIMGQF--DHPNIIRLEGVVT--R------GRLAMIVTEYMENGSLDTFLR-----TH--------------------------------------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSDL--------GYVHRDLAARNVLVDSNLVCKVSDFGLSRVL-----E-----D--DPDAAYTTTGGKIPIRWTAPEAIA------FRT---FSSASDVWSFGVVMWEVLAYGE----------RP---------------YWNM-----TNRDVISSV----EE----GYR----LPAPMGCP-------------------------------------------HALHQ-LMLDCWHKDRAQRPR-FS-QIVSVL----------------
---L-RKVKVLGSGAFGTVYKGIWIP------------DGENVKIPVAIKVLR-E-NTS-PKA-NKEIL-D--EAYVMAGV--GSPYVSRLLGICL---------TSTVQLVTQLMPYGCLLDHVR-----EN--------------------------------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLEDV--------RLVHRDLAARNVLVKSPNHVKITDFGLARLL-----D-----I--DETE-YHADGGKVPIKWMALESIL------RRR---FTHQSDVWSYGVTVWELMTFGA----------KP---------------YDGI-----PAREIPDLL----EK----GER----LPQPPICT-------------------------------------------IDVYM-IMVKCWMIDSECRPR-FR-ELVSE--F--------------
---L-KRVKVLGSGAFGTVYKGIWVP------------EGETVKIPVAIKILN-E-TTG-PKA-NVEFM-D--EALIMASM--DHPHLVRLLGVCL---------SPTIQLVTQLMPHGCLLEYVH-----EH--------------------------------------------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEER--------RLVHRDLAARNVLVKSPNHVKITDFGLARLL-----E-----G--DEKE-YNADGGKMPIKWMALECIH------YRK---FTHQSDVWSYGVTIWELMTFGG----------KP---------------YDGI-----PTREIPDLL----EK----GER----LPQPPICT-------------------------------------------IDVYM-VMVKCWMIDADSRPK-FK-ELAAE--F--------------
---L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKMLK-S-DAT-EKD-LSDLI-S--EMEMMKMIG-KHKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLQ-----ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--------KCIHRDLAARNVLVTEDNVMKIADFGLARDI-----H-----H--IDYY-KKTTNGRLPVKWMAPEALF------DRI---YTHQSDVWSFGVLLWEIFTLGG----------SP---------------YPGV-----PVEELFKLL----KE----GHR----MDKPSNCT-------------------------------------------NELYM-MMRDCWHAVPSQRPT-FK-QLVEDL----------------
----ITLERRLGTGCFGDVWLGTWN-----------------GSTKVAVKTLK-P-GTM-SP---KAFL-E--EAQVMKLL--RHDKLVQLYAVVS---------EEPIYIVTEFMCHGSLLDFLK-----NP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERM--------NYIHRDLRAANILVGERLACKIADFGLARLI-----------K--DDEY-NPCQGSKFPIKWTAPEAAL------FGR---FTIKSDVWSFGILLTELITKGR----------IP---------------YPGM-----NKREVLEQV----EQ----GYH----MPCPPGCP-------------------------------------------ASLYE-AMEQTWRLDPEERPT-FE-YLQSFL----------------
----IQLLKRLGSGQFGEVWEGLWN-----------------NTTPVAVKTLK-P-GSM-DP---NDFL-R--EAQIMKNL--RHPKLIQLYAVCT--L------EDPIYIITELMRHGSLQEYLQ-----ND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESR--------NYIHRDLAARNVLVGEHNIYKVADFGLARVFK---VD-----N--EDIY-ESRHEIKLPVKWTAPEAIR------SNK---FSIKSDVWSFGILLYEIITYGK----------MP---------------YSGM-----TGAQVIQML----AQ----NYR----LPQPSNCP-------------------------------------------QQFYN-IMLECWNAEPKERPT-FE-TLRWK--L--------------
----LQLIKRLGNGQFGEVWMGTWN-----------------GNTKVAIKTLK-P-GTM-SP---ESFL-E--EAQIMKKL--KHDKLVQLYAVVS---------EEPIYIVTEYMNKGSLLDFLK-----DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERM--------NYIHRDLRSANILVGNGLICKIADFGLARLI-----------E--DNEY-TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELVTKGR----------VP---------------YPGM-----NNREVLEQV----ER----GYR----MPCPQDCP-------------------------------------------ISLHE-LMIHCWKKDPEERPT-FE-YLQSFL----------------
----LKLEKKLGAGQFGEVWMATYN-----------------KHTKVAVKTMK-P-GSM-SV---EAFL-A--EANVMKTL--QHDKLVKLHAVVT---------KEPIYIITEFMAKGSLLDFLK-----SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR--------NYIHRDLRAANILVSASLVCKIADFGLARVI-----------E--DNEY-TAREGAKFPIKWTAPEAIN------FGS---FTIKSDVWSFGILLMEIVTYGR----------IP---------------YPGM-----SNPEVIRAL----ER----GYR----MPRPENCP-------------------------------------------EELYN-IMMRCWKNRPEERPT-FE-YIQSV--L--------------
----ITMSRELGQGSFGMVYEGVAKG-----------VVKDEPETRVAIKTVN-E-AAS-MRE-RIEFL-N--EASVMKEF--NCHHVVRLLGVVS--Q------GQPTLVIMELMTRGDLKSYLR-----SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNAN--------KFVHRDLAARNCMVAEDFTVKIGDFGMTRDI-----Y-----E--TDYY-RKGGKGLLPVRWMSPESLK------DGV---FTTYSDVWSFGVVLWEIATLAE----------QP---------------YQGL-----SNEQVLRFV----ME----GGL----LDKPDNCP-------------------------------------------DMLFE-LMRMCWQYNPKMRPS-FL-EIISS--I--------------
----ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAVKTVN-E-SAS-LRE-RIEFL-N--EASVMKGF--TCHHVVRLLGVVS--K------GQPTLVVMELMAHGDLKSYLR-----SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK--------KFVHRDLAARNCMVAHDFTVKIGDFGMTRDI-----Y-----E--TDYY-RKGGKGLLPVRWMAPESLK------DGV---FTTSSDMWSFGVVLWEITSLAE----------QP---------------YQGL-----SNEQVLKFV----MD----GGY----LDQPDNCP-------------------------------------------ERVTD-LMRMCWQFNPKMRPT-FL-EIVNLL----------------
FSEE----LKIGEGGFGCVYRAVMR----------------NTV--YAVKRLKEN-ADLEWT---AVKQSFLTEVEQLSRF--RHPNIVDFAGYCA--Q------NGFYCLVYGFLPNGSLEDRLHCQTQACP----------------------------------------------------------------------------------------------------PLSWPQRLDILLGTARAIQFLHQDS------PSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAG--SSPSQSSMVART-QT---VRGTLAYLPEEYIK------TGR---LAVDTDTFSFGVVVLETLA-GQ----------RA---------------VKTHG---AR-TKYLKDL----VE----EEA----EEAGVALRST---QSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQ-LACCCLHRRAKRRPP-MT-QVYE----RL------------
----LTFVQEIGSGQFGLVHLGYWL-----------------NKDKVAIKTIR-E-GAM-SE---EDFI-E--EAEVMMKL--SHPKLVQLYGVCL--E------QAPICLVFEFMEHGCLSDYLR-----TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEA--------CVIHRDLAARNCLVGENQVIKVSDFGMTRFV-----------L--DDQY-TSSTGTKFPVKWASPEVFS------FSR---YSSKSDVWSFGVLMWEVFSEGK----------IP---------------YENR-----SNSEVVEDI----ST----GFR----LYKPRLAS-------------------------------------------THVYQ-IMNHCWKERPEDRPA-FS-RLLRQL----------------
----LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAVKKLQ-H-STE--EH-LRDFE-R--EIEILKSL--QHDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ-----KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK--------RYIHRDLATRNILVENENRVKIGDFGLTKVL----PQ-----D--KEYY-KVKEPGESPIFWYAPESLT------ESK---FSVASDVWSFGVVLYELFTYIE----------KSKSPPAEFMRMIGNDKQGQM-----IVFHLIELL----KN----NGR----LPRPDGCP-------------------------------------------DEIYM-IMTECWNNNVNQRPS-FR-DLA----LRV------------
---L-KYISQLGKGNFGSVELCRYDP------------LGDNTGALVAVKQLQ-H-SGP-DQ--QRDFQ-R--EIQILKAL--HSDFIVKYRGVSYGPG------RQSLRLVMEYLPSGCLRDFLQ-----RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSR--------RCVHRDLAARNILVESEAHVKIADFGLAKLL----PL-----D--KDYY-VVREPGQSPIFWYAPESLS------DNI---FSRQSDVWSFGVVLYELFTYCD----------KSCSPSAE--FLRMMGCERDV-P---ALCRLLELL----EE----GQR----LPAPPACP-------------------------------------------AEVHE-LMKLCWAPSPQDRPS-FS-ALGP---QL-------------
----LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAVKMLK-P-SAH-LTE-REALM-S--ELKVLSYLG-NHMNIVNLLGACT--I------GGPTLVITEYCCYGDLLNFLR-----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK--------NCIHRDLAARNILLTHGRITKICDFGLARDI-----K-----N--DSNY-VVKGNARLPVKWMAPESIF------NCV---YTFESDVWSYGIFLWELFSLGS----------SP---------------YPGM-P---VDSKFYKMI----KE----GFR----MLSPEHAP-------------------------------------------AEMYD-IMKTCWDADPLKRPT-FK-QIVQL--I--------------
----LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSLK-Q-GSM-SP---DAFL-A--EANLMKQL--QHQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK-----TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVSDTLSCKIADFGLARLI-----------E--DNEY-TAREGAKFPIKWTAPEAIN------YGT---FTIKSDVWSFGILLTEIVTHGR----------IP---------------YPGM-----TNPEVIQNL----ER----GYR----MVRPDNCP-------------------------------------------EELYQ-LMRLCWKERPEDRPT-FD-YLRSV--L--------------
----IKLVKRLGAGQFGEVWMGYYN-----------------NSTKVAVKTLK-P-GTM-SV---QAFL-E--EANLMKTL--QHDKLVRLYAVVT--R------EEPIYIITEYMAKGSLLDFLK-----SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERK--------NYIHRDLRAANVLVSESLMCKIADFGLARVI-----------E--DNEY-TAREGAKFPIKWTAPEAIN------FGC---FTIKSDVWSFGILLYEIVTYGK----------IP---------------YPGR-----TNADVMTAL----SQ----GYR----MPRVENCP-------------------------------------------DELYD-IMKMCWKEKAEERPT-FD-YLQSV--L--------------
----YQNLSPVGSGAYGSVCAAFDT----------------KTGLRVAVKKLSRP-FQSIIH---AKRTYR--ELRLLKHM--KHENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK-----CQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSA--------DIIHRDLKPSNLAVNEDCELKILDFGLAR--------------HTDDEM-TG---YVATRWYRAPEIML-----NWMH---YNQTVDIWSVGCIMAELLT-GR----------TL---------------FPGT-----DHIDQLKLI----LR----LVG----TPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVD-LLEKMLVLDSDKRIT-AA-QALAHAYF--------------
--IV--LKWELGEGAFGKVFLAECHN-----------LLPEQDKMLVAVKALK-E-ASE-SA--RQDFQ-R--EAELLTML--QHQHIVRFFGVCT--E------GRPLLMVFEYMRHGDLNRFLR-----SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGL--------HFVHRDLATRNCLVGQGLVVKIGDFGMSRDI-----Y-----S--TDYY-RVGGRTMLPIRWMPPESIL------YRK---FTTESDVWSFGVVLWEIFTYGK----------QP---------------WYQL-----SNTEAIDCI----TQ----GRE----LERPRACP-------------------------------------------PEVYA-IMRGCWQREPQQRHS-IK-DVHARL----------------
---L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAVKMLK-P-TAR-SSE-KQALM-S--ELKIMTHLG-PHLNIVNLLGACT--K------SGPIYIITEYCFYGDLVNYLH-----KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASK--------NCVHRDLAARNVLLAQGKIVKICDFGLARDI-----M-----H--DSNY-VSKGSTFLPVKWMAPESIF------DNL---YTTLSDVWSYGILLWEIFSLGG----------TP---------------YPGM-M---VDSTFYNKI----KS----GYR----MAKPDHAT-------------------------------------------SEVYE-IMVKCWNSEPEKRPS-FY-HLSE---IV-------------
---L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAVKMLK-S-TAR-SSE-KQALM-S--ELKIMSHLG-PHLNVVNLLGACT--K------GGPIYIITEYCRYGDLVDYLH-----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASK--------NCVHRDLAARNVLICEGKLVKICDFGLARDI-----M-----R--DSNY-ISKGSTFLPLKWMAPESIF------NSL---YTTLSDVWSFGILLWEIFTLGG----------TP---------------YPEL-P---MNEQFYNAI----KR----GYR----MAQPAHAS-------------------------------------------DEIYE-IMQKCWEEKFEIRPP-FS-QLVL---LL-------------
---F-NFLMVLGKGSFGKVMLADRK----------------GTEELYAIKILKKD-VVIQDD---DVECTM-VEKRVLALL-DKPPFLTQLHSCFQ--T------VDRLYFVMEYVNGGDLMYHIQ----QVG----------------------------------------------------------------------------------------------------KFKEPQAVFYAAEISIGLFFLHKR--------GIIYRDLKLDNVMLDSEGHIKIADFGMCKEH-----------MMDGVTT-RT---FCGTPDYIAPEIIA------YQP---YGKSVDWWAYGVLLYEMLA-GQ----------PP---------------FDGE--------DEDELF----QS----IME----HNVSYPKSLS-----------------------------------------KEAVS-VCKGLMTKHPAKRLG-C----------GPEGERDVREHAFF
--FI--FHKVLGKGSFGKVLLGELK----------------GRGEYFAIKALKKD-VVLIDD---DVECTM-VEKRVLTLA-AENPFLTHLICTFQ--T------KDHLFFVMEFLNGGDLMYHIQ----DKG----------------------------------------------------------------------------------------------------RFELYRATFYAAEIMCGLQFLHSK--------GIIYRDLKLDNVLLDRDGHIKIADFGMCKEN-----------IFGESRA-ST---FCGTPDYIAPEILQ------GLK---YTFSVDWWSFGVLLYEMLI-GQ----------SP---------------FHGD--------DEDELF----ES----IRV----DTPHYPRWIT-----------------------------------------KESKD-ILEKLFEREPTKRLGVTG-NIKIHPFF--------------
--FI--LHKMLGKGSFGKVFLAEFK----------------KTNQFFAIKALKKD-VVLMDD---DVECTM-VEKRVLSLA-WEHPFLTHMFCTFQ--T------KENLFFVMEYLNGGDLMYHIQ----SCH----------------------------------------------------------------------------------------------------KFDLSRATFYAAEIILGLQFLHSK--------GIVYRDLKLDNILLDKDGHIKIADFGMCKEN-----------MLGDAKT-NT---FCGTPDYIAPEILL------GQK---YNHSVDWWSFGVLLYEMLI-GQ----------SP---------------FHGQ--------DEEELF----HS----IRM----DNPFYPRWLE-----------------------------------------KEAKD-LLVKLFVREPEKRLG-VRGDIRQHPLF--------------
--VM--LSTRIGSGSFGTVYKGKWH-------------------GDVAVKILK-VVDPT-PEQ-FQAFR-N--EVAVLRKT--RHVNILLFMGYMT---------KDNLAIVTQWCEGSSLYKHLH-----VQ--------------------------------------------------------------------------------------------------ETKFQMFQLIDIARQTAQGMDYLHAK--------NIIHRDMKSNNIFLHEGLTVKIGDFGLATVK-----S-----R--WSGS-QQVEQPTGSVLWMAPEVIR------MQDNNPFSFQSDVYSYGIVLYELMT-GE----------LP---------------YSHI-N---NRDQIIFMV----GR----GYASPDLSKLYKNCP-------------------------------------------KAMKR-LVADCVKKVKEERPL-FP-QILSS--I--------------
---L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYTTVAVKMLK-E-NAS-PSE-LRDLL-S--EFNVLKQV--NHPHVIKLYGACS--Q------DGPLLLIVEYAKYGSLRGFLR-----ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM--------KLVHRDLAARNILVAEGRKMKISDFGLSRDV-----Y-----E--EDSY-VKRSQGRIPVKWMAIESLF------DHI---YTTQSDVWSFGVLLWEIVTLGG----------NP---------------YPGI-----PPERLFNLL----KT----GHR----MERPDNCS-------------------------------------------EEMYR-LMLQCWKQEPDKRPV-FA-DISKDL----------------
---L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAIKTLK-P-GTM-SP---EAFL-Q--EAQVMKKL--RHEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK-----GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVGENLVCKVADFGLARLI-----------E--DNEY-TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELTTKGR----------VP---------------YPGM-----VNREVLDQV----ER----GYR----MPCPPECP-------------------------------------------ESLHD-LMCQCWRKEPEERPT-FE-YLQAF--L--------------
-TLE---DKELGSGNFGTVKKGYYQ--------------MKKVVKTVAVKILK-N-EAN-DPALKDELL-A--EANVMQQL--DNPYIVRMIGICE---------AESWMLVMEMAELGPLNKYLQ-----QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEES--------NFVHRDLAARNVLLVTQHYAKISDFGLSKAL-----R-----A--DENYYKAQTHGKWPVKWYAPECIN------YYK---FSSKSDVWSFGVLMWEAFSYGQ----------KP---------------YRGM-----KGSEVTAML----EK----GER----MGCPAGCP-------------------------------------------REMYD-LMNLCWTYDVENRPG-FA-AVE----LRL------------
--IV--LQESIGKGRFGEVWRGKWR----------------GEE--VAVKIFSSR-EERSWF---REA-----EIYQTVML--RHENILGFIAADN--KDN--GTWTQLWLVSDYHEHGSLFDYLN-----RY----------------------------------------------------------------------------------------------------TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS-------ATDTIDIAP-NH---RVGTKRYMAPEVLDDSINMKHFE---SFKRADIYAMGLVFWEIAR-RCSIGGIHEDYQLP---------------YYDLVPSDPSVEEMRKVV----CE----QKL----RPNIPNRWQSCEAL-------------------------------------RVMAK-IMRECWYANGAARLT-AL-RIKK----TL------------
---L-KKIRDLGEGHFGKVSLYCYDP------------TNDGTGEMVAVKALK-A-DCG-PQH-RSGWK-Q--EIDILRTL--YHEHIIKYKGCCEDQG------EKSLQLVMEYVPLGSLRDYLP-----RH----------------------------------------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHAQ--------HYIHRDLAARNVLLDNDRLVKIGDFGLAKAV----PE-----G--HEYY-RVREDGDSPVFWYAPECLK------EYK---FYYASDVWSFGVTLYELLTHCD----------SSQSPPTKF-LELIGIAQGQM-----TVLRLTELL----ER----GER----LPRPDKCP-------------------------------------------CEVYH-LMKNCWETEASFRPT-FE-NLIP---IL-------------
---L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAIKTLK-P-GTM-MP---EAFL-Q--EAQIMKKL--RHDKLVPLYAVVS---------EEPIYIVTEFMSKGSLLDFLK-----EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERM--------NYIHRDLRAANILVGENLVCKIADFGLARLI-----------E--DNEY-TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILQTELVTKGR----------VP---------------YPGM-----VNREVLEQV----ER----GYR----MPCPQGCP-------------------------------------------ESLHE-LMNLCWKKDPDERPT-FE-YIQSFL----------------
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