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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK DDR2 203
AGC AKT3 148
TK ALK 1116
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK AXL 527
TK BLK 241
TK BMX 422
TK BTK 402
CMGC CDC2 4
CMGC CDC2L5 705
CMGC CDK15 103
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK9 2.7.11.23
CMGC CDKL1 5
CMGC CDKL2 4
CMGC CDKL3 4
Other CHUK 15
TK CSF1R 582
CAMK DAPK1 13
CAMK DCLK3 356
TK DDR1 572
Other DSTYK 651
TK EGFR 712
TK EPHB1 619
TK EPHB2 621
TK EPHB4 615
TK EPHB6 670
TK ERBB4 718
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FLT4 845
TK FYN 271
AGC GRK4 187
AGC GRK5 186
AGC GRK6 186
TK HCK 241
CMGC ICK 4
TK IGF1R 999
TK INSR 1023
TK INSRR 979
TKL IRAK4 186
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK KDR 834
TK KIT 589
TK LTK 510
CMGC MAK 4
STE MAP3K1 1242
STE MAP3K15 649
STE MAP3K4 1342
STE MAP3K5 677
STE MAP3K6 645
TKL MAP3K7 36
CMGC MAPK1 13
CMGC MAPK12 27
CMGC MAPK7 55
CAMK MARK1 60
TK MERTK 587
TK MET 1078
TK MST1R 1082
TK MUSK 575
Other NEK1 4
Other NEK11 29
Other NEK2 8
Other NEK4 6
Other NEK5 4
Other NEK7 34
Other NEK8 4
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
STE OXSR1 17
STE PAK1 270
STE PAK2 249
STE PAK3 268
STE PAK4 321
STE PAK7 449
CMGC PCTK1 165
CMGC PCTK2 192
CMGC PCTK3 172
TK PDGFRA 593
TK PDGFRB 600
CMGC PFTK1 117
AGC PKN2 657
AGC PRKACA 44
AGC PRKACB 44
AGC PRKACG 44
AGC PRKCD 349
AGC PRKCQ 380
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
AGC PRKG2 453
AGC PRKX 49
TK PTK6 191
TKL RAF1 349
TK RET 724
TKL RIPK2 18
TKL RIPK4 22
TK ROS1 1945
AGC RPS6KB1 91
AGC RPS6KB2 67
STE SLK 34
TK SRC 270
TK SRMS 230
STE STK24 24
Other STK36 4
STE STK39 63
TK SYK 371
TK TEC 370
TKL TNNI3K 463
TK TXK 271
TK TYK2 589
TK TYRO3 518
TK YES1 277
STE YSK4 1162
TK ZAP70 338
----LTFKEKLGEGQFGEVHLCEV---EGMEKFKDKDFALDVSANQPV---LVAVKMLR-A--D-AN----KNA-RN-DFL-K----EIKIMSRL--K---DPNIIHLLAVCI--T----------DDP------LCMITEYMENGDLNQFLS---------RHEPPN-----------------------------------------------------------------------------------------SSSSDV-RTV---SYTNLKFMATQIASGMKYLSS--L-----N---FVHRDLATRNCLVG-K-----NY-TI----KIADFGMSRNL-----Y---S--GDYY--------------RIQGRAVLPIRWMSWESIL-----LGK---FTTASDVWAFGVTLWETFTFCQEQP---------------YSQL-----------SDEQVIENT----GEFFRDQGRQ-TYLPQPAICP-------------------------------DSVYK-LMLSCWRRDTKNRPS-----FQ-EIHL---LL--------
--FD--YLKLLGKGTFGKVILVRE---K----------------ASGK---YYAMKILKKE--V-IIA---KD---E-VAHTL---TESRVLKNT--R---HPFLTSLKYSFQ--T----------KDR------LCFVMEYVNGGELFFHLS--------RER-----------------------------------------------------------------------------------------------------VF---SEDRTRFYGAEIVSALDYLHS--G-----K---IVYRDLKLENLMLD-K-----DG-HI----KITDFGLCKEG---------ITDAATM--------------KT---FCGTPEYLAPEVLE-----DND---YGRAVDWWGLGVVMYEMMC-GR-LP---------------FYNQ--------------DHEKLF----EL----ILM----EDIKFPRTLS-----------------------------SDAKS-LLSGLLIKDPNKRLGGGPDDAK-EIMRHSFF---------
---I-TLIRGLGHGAFGEVYEGQV---SG-----------MPNDPSPL---QVAVKTLP-E--V-CS----EQD-EL-DFL-M----EALIISKF--N---HQNIVRCIGVSL--Q----------SLP------RFILLELMAGGDLKSFLR---------ETRP--------------------------------------------------------------------------------------------RPSQP-SSL---AMLDLLHVARDIACGCQYLEE--N-----H---FIHRDIAARNCLLT-CP--GPGR-VA----KIGDFGMARDI-----Y---R--ASYY--------------RKGGCAMLPVKWMPPEAFM-----EGI---FTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK-----------SNQEVLEFV----TS----GGR----MDPPKNCP-------------------------------GPVYR-IMTQCWQHQPEDRPN-----FA-IILER--I---------
----FEIGRPLGKGKFGNVYLARE---K----------------QSKF---ILALKVLFKA--QLEKA---GV---E-HQLRR----EVEIQSHL--R---HPNILRLYGYFH--D----------ATR------VYLILEYAPLGTVYRELQ--------KLS-----------------------------------------------------------------------------------------------------KF---DEQRTATYITELANALSYCHS--K-----R---VIHRDIKPENLLLG-S-----AG-EL----KIADFGWSV-----------HAPSSRR--------------TT---LCGTLDYLPPEMIE-----GRM---HDEKVDLWSLGVLCYEFLV-GK-PP---------------FEAN--------------TYQETY----KR----ISR----VEFTFPDFVT-----------------------------EGARD-LISRLLKHNPSQRPM-----LR-EVLEHPWI---------
----FEIGRPLGKGKFGNVYLARE---K----------------KSHF---IVALKVLFKS--Q-IEK---EG---V-EHQLR---REIEIQAHL--H---HPNILRLYNYFY--D----------RRR------IYLILEYAPRGELYKELQ--------KSC-----------------------------------------------------------------------------------------------------TF---DEQRTATIMEELADALMYCHG--K-----K---VIHRDIKPENLLLG-L-----KG-EL----KIADFGWSV-----------HAPSLRR--------------KT---MCGTLDYLPPEMIE-----GRM---HNEKVDLWCIGVLCYELLV-GN-PP---------------FESA--------------SHNETY----RR----IVK----VDLKFPASVP-----------------------------MGAQD-LISKLLRHNPSERLP-----LA-QVSAHPWV---------
----FEIGRPLGKGKFGNVYLARL---K----------------ESHF---IVALKVLFKS--Q-IEK---EG---L-EHQLR---REIEIQAHL--Q---HPNILRLYNYFH--D----------ARR------VYLILEYAPRGELYKELQ--------KSE-----------------------------------------------------------------------------------------------------KL---DEQRTATIIEELADALTYCHD--K-----K---VIHRDIKPENLLLG-F-----RG-EV----KIADFGWSV-----------HTPSLRR--------------KT---MCGTLDYLPPEMIE-----GRT---YDEKVDLWCIGVLCYELLV-GY-PP---------------FESA--------------SHSETY----RR----ILK----VDVRFPLSMP-----------------------------LGARD-LISRLLRYQPLERLP-----LA-QILKHPWV---------
---V-ALGKTLGEGEFGAVMEGQL---N--------------QDDSIL---KVAVKTMK-I-AI-CT----RSE-LE-DFL-S----EAVCMKEF--D---HPNVMRLIGVCF--Q----------GSERESFPAPVVILPFMKHGDLHSFLL---------YSRL---------------------------------------------------------------------------------------------GDQP-VYL---PTQMLVKFMADIASGMEYLST--K-----R---FIHRDLAARNCMLN-E-----NM-SV----CVADFGLSKKI-----Y---N--GDYY--------------RQGRIAKMPVKWIAIESLA-----DRV---YTSKSDVWSFGVTMWEIATRGQ-TP---------------YPGV-----------ENSEIYDYL----RQ----GNR----LKQPADCL-------------------------------DGLYA-LMSRCWELNPQDRPS-----FT-ELREDL-----------
---L-RLVRKLGSGQFGEVWMGYY---K-----------------NNM---KVAIKTLK-E--G-TM----SP---E-AFL-G----EANVMKAL--Q---HERLVRLYAVVT-------------KEP------IYIVTEYMARGCLLDFLK---------TD-------------------------------------------------------------------------------------------------EG-SRL---SLPRLIDMSAQIAEGMAYIER--M-----N---SIHRDLRAANILVS-E-----AL-CC----KIADFGLARII------------DSEY--------------TAQEGAKFPIKWTAPEAIH-----FGV---FTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM-----------SNPEVIRNL----ER----GYR----MPRPDTCP-------------------------------PELYRGVIAECWRSRPEERPT-----FE-FLQSV--L---------
----ITLLKELGSGQFGVVQLGKW---K-----------------GQY---DVAVKMIK-E--G-SM----SE---D-EFF-Q----EAQTMMKL--S---HPKLVKFYGVCS--K----------EYP------IYIVTEYISNGCLLNYLR---------SH--------------------------------------------------------------------------------------------------G-KGL---EPSQLLEMCYDVCEGMAFLES--H-----Q---FIHRDLAARNCLVD-R-----DL-CV----KVSDFGMTRYV---------L--DDQY--------------VSSVGTKFPVKWSAPEVFH-----YFK---YSSKSDVWAFGILMWEVFSLGK-QP---------------YDLY-----------DNSQVVLKV----SQ----GHR----LYRPHLAS-------------------------------DTIYQ-IMYSCWHELPEKRPT-----FQ-QLLSS--I---------
----LTFLKELGTGQFGVVKYGKW---R-----------------GQY---DVAIKMIK-E--G-SM----SE---D-EFI-E----EAKVMMNL--S---HEKLVQLYGVCT--K----------QRP------IFIITEYMANGCLLNYLR---------EM--------------------------------------------------------------------------------------------------R-HRF---QTQQLLEMCKDVCEAMEYLES--K-----Q---FLHRDLAARNCLVN-D-----QG-VV----KVSDFGLSRYV---------L--DDEY--------------TSSVGSKFPVRWSPPEVLM-----YSK---FSSKSDIWAFGVLMWEIYSLGK-MP---------------YERF-----------TNSETAEHI----AQ----GLR----LYRPHLAS-------------------------------EKVYT-IMYSCWHEKADERPT-----FK-ILLSN--I---------
----YTKIEKIGEGTYGVVYKGRH---K----------------TTGQ---VVAMKKIRLE--S-EEE---GV---P-STAIR----EISLLKEL--R---HPNIVSLQDVLM--Q----------DSR------LYLIFEFLSM-DLKKYLDS-----IPPGQ-----------------------------------------------------------------------------------------------------YM---DSSLVKSYLYQILQGIVFCHS--R-----R---VLHRDLKPQNLLID-D-----KG-TI----KLADFGLARAF---------GIPIRVY--------------TH---EVVTLWYRSPEVLL----GSAR---YSTPVDIWSIGTIFAELAT-KK-PL---------------FHGD-----------SEIDQLFRI----FR----ALG----TPNNEVWPEVESLQDYKNTFPKWKP---GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-----GK-MALNHPYF---------
---F-DIIGIIGEGTYGQVYKARD---K----------------DTGE---MVALKKVRLD--N-EKE---GF---P-ITAIR----EIKILRQL--T---HQSIINMKEIVT--DKEDALDFKKDKGA------FYLVFEYMDH-DLMGLLE-------SGLV-----------------------------------------------------------------------------------------------------HF---NENHIKSFMRQLMEGLDYCHK--K-----N---FLHRDIKCSNILLN-N-----RG-QI----KLADFGLARLY--------SSEESRPY--------------TN---KVITLWYRPPELLL----GEER---YTPAIDVWSCGCILGELFT-KK-PI---------------FQAN-----------QELAQLELI----SR----ICG----SPCPAVWPDVIKLPYFNTMKPKKQY--RRKLREEFVFIPAAALD-LFDYMLALDPSKRCT-----AE-QALQCEF-L--------
--YL--NLEKLGEGSYATVYKGIS---R----------------INGQ---LVALKVISMN--A-EEG---VP-----FTAIR----EASLLKGL--K---HANIVLLHDIIH--T----------KET------LTFVFEYMHT-DLAQYMS-------QHPG-----------------------------------------------------------------------------------------------------GL---HPHNVRLFMFQLLRGLAYIHH--Q-----H---VLHRDLKPQNLLIS-H-----LG-EL----KLADFGLARAK---------SIPSQTY--------------SS---EVVTLWYRPPDALL----GATE---YSSELDIWGAGCIFIEMFQ-GQ-PL---------------FPGV----------SNILEQLEKI----WE----VLG----VPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAED-LASQMLKGFPRDRVS-----AQ-EALVHDYF---------
----FQKVEKIGEGTYGVVYKARN---K----------------LTGE---VVALKKIRLD--T-ETE---GV---P-STAIR----EISLLKEL--N---HPNIVKLLDVIH--T----------ENK------LYLVFEFLHQ-DLKKFMDA------SALT-----------------------------------------------------------------------------------------------------GI---PLPLIKSYLFQLLQGLAFCHS--H-----R---VLHRDLKPQNLLIN-T-----EG-AI----KLADFGLARAF---------GVPVRTY--------------TH---EVVTLWYRAPEILL----GCKY---YSTAVDIWSLGCIFAEMVT-RR-AL---------------FPGD-----------SEIDQLFRI----FR----TLG----TPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-----AK-AALAHPFF---------
----FQKVEKIGEGTYGVVYKAKN---R----------------ETGQ---LVALKKIRLD--L-EME---GV---P-STAIR----EISLLKEL--K---HPNIVRLLDVVH--N----------ERK------LYLVFEFLSQ-DLKKYMDS------TPGS-----------------------------------------------------------------------------------------------------EL---PLHLIKSYLFQLLQGVSFCHS--H-----R---VIHRDLKPQNLLIN-E-----LG-AI----KLADFGLARAF---------GVPLRTY--------------TH---EVVTLWYRAPEILL----GSKF---YTTAVDIWSIGCIFAEMVT-RK-AL---------------FPGD-----------SEIDQLFRI----FR----MLG----TPSEDTWPGVTQLPDYKGSFPKWTR---KGLEEIVPNLEPEGRD-LLMQLLQYDPSQRIT-----AK-TALAHPYF---------
---Y-EPVAEIGVGAYGTVYKARD---P----------------HSGH---FVALKSVRVP--N-GGGGGGGL---P-ISTVR----EVALLRRL--EAFEHPNVVRLMDVCA--TSR-----TDREIK------VTLVFEHVDQ-DLRTYLDK------APPP-----------------------------------------------------------------------------------------------------GL---PAETIKDLMRQFLRGLDFLHA--N-----C---IVHRDLKPENILVT-S-----GG-TV----KLADFGLARI----------YSYQMAL--------------TP---VVVTLWYRAPEVLL-----QST---YATPVDMWSVGCIFAEMFR-RK-PL---------------FCGN-----------SEADQLGKI----FD----LIG----LPPEDDWPRDVSLPRGAFPPRGPR-----PVQSVVPEMEESGAQ-LLLEMLTFNPHKRIS-----AF-RALQHSYL---------
----YEKLEKIGEGTYGTVFKAKN---R----------------ETHE---IVALKRVRLD--D-DDE---GV---P-SSALR----EICLLKEL--K---HKNIVRLHDVLH--S----------DKK------LTLVFEFCDQ-DLKKYFD-------SCNG-----------------------------------------------------------------------------------------------------DL---DPEIVKSFLFQLLKGLGFCHS--R-----N---VLHRDLKPQNLLIN-R-----NG-EL----KLADFGLARAF---------GIPVRCY--------------SA---EVVTLWYRPPDVLF----GAKL---YSTSIDMWSAGCIFAELANAGR-PL---------------FPGN-----------DVDDQLKRI----FR----LLG----TPTEEQWPSMTKLPDYKPYPMYPAT---TSLVNVVPKLNATGRD-LLQNLLKCNPVQRIS-----AE-EALQHPYF---------
----YECVAEIGEGAYGKVFKARD---L----------------KNGG--RFVALKRVRVQ--T-GEE---GM---P-LSTIR----EVAVLRHL--ETFEHPNVVRLFDVCT--VSR-----TDRETK------LTLVFEHVDQ-DLTTYLDK------VPEP-----------------------------------------------------------------------------------------------------GV---PTETIKDMMFQLLRGLDFLHS--H-----R---VVHRDLKPQNILVT-S-----SG-QI----KLADFGLARI----------YSFQMAL--------------TS---VVVTLWYRAPEVLL-----QSS---YATPVDLWSVGCIFAEMFR-RK-PL---------------FRGS-----------SDVDQLGKI----LD----VIG----LPGEEDWPRDVALPRQAFHSKSAQ-----PIEKFVTDIDELGKD-LLLKCLTFNPAKRIS-----AY-SALSHPYF---------
----YEKLAKIGQGTFGEVFKARH---R----------------KTGQ---KVALKKVLME--N-EKE---GF---P-ITALR----EIKILQLL--K---HENVVNLIEICR--TKASP--YNRCKGS------IYLVFDFCEH-DLAGLLS-------NVLV-----------------------------------------------------------------------------------------------------KF---TLSEIKRVMQMLLNGLYYIHR--N-----K---ILHRDMKAANVLIT-R-----DG-VL----KLADFGLARAFSL-----AKNSQPNRY--------------TN---RVVTLWYRPPELLL----GERD---YGPPIDLWGAGCIMAEMWT-RS-PI---------------MQGN-----------TEQHQLALI----SQ----LCG----SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALD-LIDKLLVLDPAQRID-----SD-DALNHDFF---------
----YEKIGKIGEGSYGVVFKCRN---R----------------DTGQ---IVAIKKFLES--E-DDP---VI---K-KIALR----EIRMLKQL--K---HPNLVNLLEVFR--R----------KRR------LHLVFEYCDHTVLHELDR--------YQR-----------------------------------------------------------------------------------------------------GV---PEHLVKSITWQTLQAVNFCHK--H-----N---CIHRDVKPENILIT-K-----HS-VI----KLCDFGFARLL---------AGPSDYY--------------TD---YVATRWYRSPELLV----GDTQ---YGPPVDVWAIGCVFAELLS-GV-PL---------------WPGK-----------SDVDQLYLI----RK----TLG----DLIPRHQQVFSTNQYFSGVKIPDPED-MEPLELKFPNISYPALG-LLKGCLHMDPTQRLT-----CE-QLLHHPYF---------
----YENLGLVGEGSYGMVMKCRN---K----------------DTGR---IVAIKKFLES--D-DDK---MV---K-KIAMR----EIKLLKQL--R---HENLVNLLEVCK--K----------KKR------WYLVFEFVDHTILDDLEL--------FPN-----------------------------------------------------------------------------------------------------GL---DYQVVQKYLFQIINGIGFCHS--H-----N---IIHRDIKPENILVS-Q-----SG-VV----KLCDFGFARTL---------AAPGEVY--------------TD---YVATRWYRAPELLV----GDVK---YGKAVDVWAIGCLVTEMFM-GE-PL---------------FPGD-----------SDIDQLYHI----MM----CLG----NLIPRHQELFNKNPVFAGVRLPEIKE-REPLERRYPKLSEVVID-LAKKCLHIDPDKRPF-----CA-ELLHHDFF---------
----YETLGKVGEGSYGTVMKCKH---K----------------NTGQ---IVAIKIFYER--P-EQS---VN---K--IAMR----EIKFLKQF--H---HENLVNLIEVFR--Q----------KKK------IHLVFEFIDHTVLDELQH--------YCH-----------------------------------------------------------------------------------------------------GL---ESKRLRKYLFQILRAIDYLHS--N-----N---IIHRDIKPENILVS-Q-----SG-IT----KLCDFGFARTL---------AAPGDIY--------------TD---YVATRWYRAPELVL----KDTS---YGKPVDIWALGCMIIEMAT-GN-PY---------------LPSS-----------SDLDLLHKI----VL----KVG----N-LSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLAD-IVHACLQIDPADRIS-----SS-DLLHHEYF---------
---W-EMRERLGTGGFGNVCLYQH---R----------------ELDL---KIAIKSCRLE--L-STK---NR---E-R-WCH----EIQIMKKL--N---HANVVKACDVPE--ELN-----ILIHDV------PLLAMEYCSGGDLRKLLNK-----PENCC-----------------------------------------------------------------------------------------------------GL---KESQILSLLSDIGSGIRYLHE--N-----K---IIHRDLKPENIVLQ-D-----VG-GKI-IHKIIDLGYAKD----------VDQGSLC--------------TS---FVGTLQYLAPELFE-----NKP---YTATVDYWSFGTMVFECIA-GY-RP---------------FLHHLQPFTWHEKIKKKDPKCIFA----CE----EMS----GEVRFSSHLPQPNSLCS-------------------LVVEPMEN-WLQLMLNWDPQQRG-----------------GPVDLTLKQ
----LQFGKTLGAGAFGKVVEATA---FG-----------LGKEDAVL---KVAVKMLK-S--T-AH----ADE-KE-ALM-S----ELKIMSHLG-Q---HENIVNLLGACT--H----------GGP------VLVITEYCCYGDLLNFLR---------RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDG-RPL---ELRDLLHFSSQVAQGMAFLAS--K-----N---CIHRDVAARNVLLT-N-----GH-VA----KIGDFGLARDI-----M---N--DSNY--------------IVKGNARLPVKWMAPESIF-----DCV---YTVQSDVWSYGILLWEIFSLGL-NP---------------YPGI-L---------VNSKFYKLV----KD----GYQ----MAQPAFAP-------------------------------KNIYS-IMQACWALEPTHRPT-----FQ-QICSFL-----------
----YDTGEELGSGQFAVVKKCRE---K----------------STGL---QYAAKFIKKR--R-TKS---SR---R-GVSREDIEREVSILKEI--Q---HPNVITLHEVYE--N----------KTD------VILILELVAGGELFDFLA--------EKE-----------------------------------------------------------------------------------------------------SL---TEEEATEFLKQILNGVYYLHS--L-----Q---IAHFDLKPENIMLL-D-----RN-VPKPRIKIIDFGLAHK----------IDFGNEF--------------KN---IFGTPEFVAPEIVN-----YEP---LGLEADMWSIGVITYILLS-GA-SP---------------FLGD--------------TKQETL----AN----VSA----VNYEFEDEYFSNTS-------------------------ALAKD-FIRRLLVKDPKKRMT-----IQ-DSLQHPWI---------
----YETGRVIGDGNFAVVKECRH---R----------------ETRQ---AYAMKIIDKS--R-LKG---KE---D-MV-DS----EILIIQSL--S---HPNIVKLHEVYE--T----------DME------IYLILEYVQGGDLFDAII--------ESV-----------------------------------------------------------------------------------------------------KF---PEPDAALMIMDLCKALVHMHD--K-----S---IVHRDLKPENLLVQ-R-----NE-DKSTTLKLADFGLAK------------HVVRPI--------------FT---VCGTPTYVAPEILS-----EKG---YGLEVDMWAAGVILYILLC-GF-PP---------------FRSP------------ERDQDELF----NI----IQL----GHFEFLPPYWDNIS-------------------------DAAKD-LVSRLLVVDPKKRYT-----AH-QVLQHPWI---------
----LRFKEKLGEGQFGEVHLCEV---DSPQDLVSLDFPLNVRKGHPL---LVAVKILR-P--D-AT----KNA-RN-DFL-K----EVKIMSRL--K---DPNIIRLLGVCV--Q----------DDP------LCMITDYMENGDLNQFLS---------AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQG-PTI---SYPMLLHVAAQIASGMRYLAT--L-----N---FVHRDLATRNCLVG-E-----NF-TI----KIADFGMSRNL-----Y---A--GDYY--------------RVQGRAVLPIRWMAWECIL-----MGK---FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL-----------TDEQVIENAGEFFRD----QGRQ-VYLSRPPACP-------------------------------QGLYE-LMLRCWSRESEQRPP-----FS-QLHRFL-----------
---K--LGQELGRGQYGVVYLCDN---W----------------GGHF---PCALKSVVPP--D-EKH---WN---D---LAL----EFHYMRSL-PK---HERLVDLHGSVI--DYNY---GGGSSIA------VLLIMERLHR-DLYTGLK----------A-----------------------------------------------------------------------------------------------------GL---TLETRLQIALDVVEGIRFLHS--Q-----G---LVHRDIKLKNVLLD-K-----QN-RA----KITDLGFCK------------PEAMMS--------------GS---IVGTPIHMAPELFT------GK---YDNSVDVYAFGILFWYICS-GS-VK---------------LPEAF---------ERCASKDHLW----NN----VRR----GARPERLPVF---D-------------------------EECWQ-LMEACWDGDPLKRP-----------------LLGIVQPML
---F-KKIKVLGSGAFGTVYKGLW---IP------------EGEKVKI---PVAIKELR-E--A-TS----PKA-NK-EIL-D----EAYVMASV--D---NPHVCRLLGICL-------------TST------VQLITQLMPFGCLLDYVR---------EH--------------------------------------------------------------------------------------------------K-DNI---GSQYLLNWCVQIAKGMNYLED--R-----R---LVHRDLAARNVLVK-T-----PQ-HV----KITDFGLAKLL-----G---A--EEKE--------------YHAEGGKVPIKWMALESIL-----HRI---YTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI-----------PASEISSIL----EK----GER----LPQPPICT-------------------------------IDVYM-IMVKCWMIDADSRPK-----FR-ELI----IEF-------
---V-KIEEVIGAGEFGEVYKGRL---K-------------LPGKREI---YVAIKTLK-A--G-YS----EKQ-RR-DFL-S----EASIMGQF--D---HPNIIRLEGVVT--K----------SRP------VMIITEFMENGALDSFLR---------QN--------------------------------------------------------------------------------------------------D-GQF---TVIQLVGMLRGIAAGMKYLAE--M-----N---YVHRDLAARNILVN-S-----NL-VC----KVSDFGLSRYLQ--DDT---S--DPTY--------------TSSLGGKIPVRWTAPEAIA-----YRK---FTSASDVWSYGIVMWEVMSFGE-RP---------------YWDM-----------SNQDVINAI----EQ----DYR----LPPPMDCP-------------------------------AALHQ-LMLDCWQKDRNSRPR-----FA-EIVNTL-----------
---V-KIEQVIGAGEFGEVCSGHL---K-------------LPGKREI---FVAIKTLK-S--G-YT----EKQ-RR-DFL-S----EASIMGQF--D---HPNVIHLEGVVT--K----------STP------VMIITEFMENGSLDSFLR---------QN--------------------------------------------------------------------------------------------------D-GQF---TVIQLVGMLRGIAAGMKYLAD--M-----N---YVHRDLAARNILVN-S-----NL-VC----KVSDFGLSRFLE--DDT---S--DPTY--------------TSALGGKIPIRWTAPEAIQ-----YRK---FTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM-----------TNQDVINAI----EQ----DYR----LPPPMDCP-------------------------------SALHQ-LMLDCWQKDRNHRPK-----FG-QIVNTL-----------
---V-KIEEVIGAGEFGEVCRGRL---K-------------APGKKES---CVAIKTLK-G--G-YT----ERQ-RR-EFL-S----EASIMGQF--E---HPNIIRLEGVVT--N----------SMP------VMILTEFMENGALDSFLR---------LN--------------------------------------------------------------------------------------------------D-GQF---TVIQLVGMLRGIASGMRYLAE--M-----S---YVHRDLAARNILVN-S-----NL-VC----KVSDFGLSRFLE--ENS---S--DPTY--------------TSSLGGKIPIRWTAPEAIA-----FRK---FTSASDAWSYGIVMWEVMSFGE-RP---------------YWDM-----------SNQDVINAI----EQ----DYR----LPPPPDCP-------------------------------TSLHQ-LMLDCWQKDRNARPR-----FP-QVVSAL-----------
----IKIEEVIGTGSFGEVRQGRL---Q-------------PRGRREQ---TVAIQALW-A--G-GA----ESL-QM-TFL-G----RAAVLGQF--Q---HPNILRLEGVVT--K----------SRP------LMVLTEFMELGPLDSFLR---------QR--------------------------------------------------------------------------------------------------E-GQF---SSLQLVAMQRGVAAAMQYLSS--F-----A---FVHRSLSAHSVLVN-S-----HL-VC----KVARLGHSPQG-----------------------------------PSCLLRWAAPEVIA-----HGK---HTTSSDVWSFGILMWEVMSYGE-RP---------------YWDM-----------SEQEVLNAI----EQ----EFR----LPPPPGCP-------------------------------PGLHL-LMLDTWQKDRARRPH-----FD-QLVA---AF--------
---L-KRVKVLGSGAFGTVYKGIW---VP------------EGETVKI---PVAIKILN-E--T-TG----PKA-NV-EFM-D----EALIMASM--D---HPHLVRLLGVCL-------------SPT------IQLVTQLMPHGCLLEYVH---------EH--------------------------------------------------------------------------------------------------K-DNI---GSQLLLNWCVQIAKGMMYLEE--R-----R---LVHRDLAARNVLVK-S-----PN-HV----KITDFGLARLL-----E---G--DEKE--------------YNADGGKMPIKWMALECIH-----YRK---FTHQSDVWSYGVTIWELMTFGG-KP---------------YDGI-----------PTREIPDLL----EK----GER----LPQPPICT-------------------------------IDVYM-VMVKCWMIDADSRPK-----FK-ELAAE--F---------
--VI--LGELLGKGNFGEVYKGTL---K-----------------DKT---SVAVKTCK-E--D-LP----QEL-KI-KFL-Q----EAKILKQY--D---HPNIVKLIGVCT--Q----------RQP------VYIIMELVSGGDFLTFLR---------RK--------------------------------------------------------------------------------------------------K-DEL---KLKQLVKFSLDAAAGMLYLES--K-----N---CIHRDLAARNCLVG-E-----NN-VL----KISDFGMSRQE---------D--GGVY--------------SSSGLKQIPIKWTAPEALN-----YGR---YSSESDVWSFGILLWETFSLGV-CP---------------YPGM-----------TNQQAREQV----ER----GYR----MSAPQHCP-------------------------------EDISK-IMMKCWDYKPENRPK-----FS-ELQKEL-----------
---L-VLGEQIGRGNFGEVFSGRL---R----------------ADNT---LVAVKSCR-E--T-LP----PDL-KA-KFL-Q----EARILKQY--S---HPNIVRLIGVCT--Q----------KQP------IYIVMELVQGGDFLTFLR---------TE--------------------------------------------------------------------------------------------------G-ARL---RVKTLLQMVGDAAAGMEYLES--K-----C---CIHRDLAARNCLVT-E-----KN-VL----KISDFGMSREE-----A---D--GVYA--------------ASGGLRQVPVKWTAPEALN-----YGR---YSSESDVWSFGILLWETFSLGA-SP---------------YPNL-----------SNQQTREFV----EK----GGR----LPCPELCP-------------------------------DAVFR-LMEQCWAYEPGQRPS-----FS-TIYQEL-----------
---L-VLGKPLGEGCFGQVVLAEA---IGL---------DKDKPNRVT---KVAVKMLK-S--D-AT----EKD-LS-DLI-S----EMEMMKMIG-K---HKNIINLLGACT--Q----------DGP------LYVIVEYASKGNLREYLQ---------ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPE-EQL---SSKDLVSCAYQVARGMEYLAS--K-----K---CIHRDLAARNVLVT-E-----DN-VM----KIADFGLARDI-----H---H--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRI---YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV-----------PVEELFKLL----KE----GHR----MDKPSNCT-------------------------------NELYM-MMRDCWHAVPSQRPT-----FK-QLVEDL-----------
----LTLGKPLGEGCFGQVVMAEA---VGI---------DKDKPKEAV---TVAVKMLK-D--D-AT----EKD-LS-DLV-S----EMEMMKMIG-K---HKNIINLLGACT--Q----------DGP------LYVIVEYASKGNLREYLR---------ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPE-EQM---TFKDLVSCTYQLARGMEYLAS--Q-----K---CIHRDLAARNVLVT-E-----NN-VM----KIADFGLARDI-----N---N--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRV---YTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI-----------PVEELFKLL----KE----GHR----MDKPANCT-------------------------------NELYM-MMRDCWHAVPSQRPT-----FK-QLVEDL-----------
----LTLGKPLGEGCFGQVVMAEA---IGI---------DKDRAAKPV---TVAVKMLK-D--D-AT----DKD-LS-DLV-S----EMEMMKMIG-K---HKNIINLLGACT--Q----------GGP------LYVLVEYAAKGNLREFLR---------ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPE-EQL---TFKDLVSCAYQVARGMEYLAS--Q-----K---CIHRDLAARNVLVT-E-----DN-VM----KIADFGLARDV-----H---N--LDYY--------------KKTTNGRLPVKWMAPEALF-----DRV---YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI-----------PVEELFKLL----KE----GHR----MDKPANCT-------------------------------HDLYM-IMRECWHAAPSQRPT-----FK-QLVEDL-----------
---L-VLGKPLGEGCFGQVVRAEA---FGM---------DPARPDQAS---TVAVKMLK-D--N-AS----DKD-LA-DLV-S----EMEVMKLIG-R---HKNIINLLGVCT--Q----------EGP------LYVIVECAAKGNLREFLR---------ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSE-GPL---SFPVLVSCAYQVARGMQYLES--R-----K---CIHRDLAARNVLVT-E-----DN-VM----KIADFGLARGV-----H---H--IDYY--------------KKTSNGRLPVKWMAPEALF-----DRV---YTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI-----------PVEELFSLL----RE----GHR----MDRPPHCP-------------------------------PELYG-LMRECWHAAPSQRPT-----FK-QLVEAL-----------
----ITLERRLGTGCFGDVWLGTW---N-----------------GST---KVAVKTLK-P--G-TM----SP---K-AFL-E----EAQVMKLL--R---HDKLVQLYAVVS-------------EEP------IYIVTEFMCHGSLLDFLK---------NP-------------------------------------------------------------------------------------------------EG-QDL---RLPQLVDMAAQVAEGMAYMER--M-----N---YIHRDLRAANILVG-E-----RL-AC----KIADFGLARLI---------K--DDEY--------------NPCQGSKFPIKWTAPEAAL-----FGR---FTIKSDVWSFGILLTELITKGR-IP---------------YPGM-----------NKREVLEQV----EQ----GYH----MPCPPGCP-------------------------------ASLYE-AMEQTWRLDPEERPT-----FE-YLQSFL-----------
----LHLGRVLGYGAFGKVVEASA---FG-----------IHKGSSCD---TVAVKMLK-E--G-AT----ASE-HR-ALM-S----ELKILIHIG-N---HLNVVNLLGACT-KP----------QGP------LMVIVEFCKYGNLSNFLR---------AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWL-SPL---TMEDLVCYSFQVARGMEFLAS--R-----K---CIHRDLAARNILLS-E-----SD-VV----KICDFGLARDI-----Y---K--DPDY--------------VRKGSARLPLKWMAPESIF-----DKV---YTTQSDVWSFGVLLWEIFSLGA-SP---------------YPGV-Q---------INEEFCQRL----RD----GTR----MRAPELAT-------------------------------PAIRR-IMLNCWSGDPKARPA-----FS-ELVEIL-----------
----LQLIKRLGNGQFGEVWMGTW---N-----------------GNT---KVAIKTLK-P--G-TM----SP---E-SFL-E----EAQIMKKL--K---HDKLVQLYAVVS-------------EEP------IYIVTEYMNKGSLLDFLK---------DG-------------------------------------------------------------------------------------------------EG-RAL---KLPNLVDMAAQVAAGMAYIER--M-----N---YIHRDLRSANILVG-N-----GL-IC----KIADFGLARLI---------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILLTELVTKGR-VP---------------YPGM-----------NNREVLEQV----ER----GYR----MPCPQDCP-------------------------------ISLHE-LMIHCWKKDPEERPT-----FE-YLQSFL-----------
--FR--HYRVLGKGGFGEVCACQV---R----------------ATGK---MYACKKLQKK--R-IKK---RK---G-EAMAL---NEKRILEKV--Q---SRFVVSLAYAYE--T----------KDA------LCLVLTIMNGGDLKFHIYN------LGNP-----------------------------------------------------------------------------------------------------GF---DEQRAVFYAAELCCGLEDLQR--E-----R---IVYRDLKPENILLD-D-----RG-HI----RISDLGLATE----------IPEGQRV--------------RG---RVGTVGYMAPEVVN-----NEK---YTFSPDWWGLGCLIYEMIQ-GH-SP---------------FKKY-----------KEKVKWEEV----DQ----RIK----NDTEEYSE---KFS-------------------------EDAKS-ICRMLLTKNPSKRLGCRGEGAA-GVKQHPV-F--------
---F-RQYRVLGKGGFGEVCACQV---R----------------ATGK---MYACKRLEKK--R-IKK---RK---G-ESMAL---NEKQILEKV--N---SQFVVNLAYAYE--T----------KDA------LCLVLTIMNGGDLKFHIYN------MGNP-----------------------------------------------------------------------------------------------------GF---EEERALFYAAEILCGLEDLHR--E-----N---TVYRDLKPENILLD-D-----YG-HI----RISDLGLAVK----------IPEGDLI--------------RG---RVGTVGYMAPEVLN-----NQR---YGLSPDYWGLGCLIYEMIE-GQ-SP---------------FRGR--------------KEKVKR----EE----VDR----RVLETEEVYSHKFS-------------------------EEAKS-ICKMLLTKDAKQRLGCQEEGAA-EVKRHPFF---------
---F-RQYRVLGKGGFGEVCACQV---R----------------ATGK---MYACKKLEKK--R-IKK---RK---G-EAMAL---NEKQILEKV--N---SRFVVSLAYAYE--T----------KDA------LCLVLTLMNGGDLKFHIYH------MGQA-----------------------------------------------------------------------------------------------------GF---PEARAVFYAAEICCGLEDLHR--E-----R---IVYRDLKPENILLD-D-----HG-HI----RISDLGLAVH----------VPEGQTI--------------KG---RVGTVGYMAPEVVK-----NER---YTFSPDWWALGCLLYEMIA-GQ-SP---------------FQQR-----------KKKIKREEV----ER----LVK-----EVPEEYSER--FS-------------------------PQARS-LCSQLLCKDPAERLGCRGGSAR-EVKEHPLF---------
----LKLEKKLGAGQFGEVWMATY---N-----------------KHT---KVAVKTMK-P--G-SM----SV---E-AFL-A----EANVMKTL--Q---HDKLVKLHAVVT-------------KEP------IYIITEFMAKGSLLDFLK---------SD-------------------------------------------------------------------------------------------------EG-SKQ---PLPKLIDFSAQIAEGMAFIEQ--R-----N---YIHRDLRAANILVS-A-----SL-VC----KIADFGLARVI---------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----FGS---FTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM-----------SNPEVIRAL----ER----GYR----MPRPENCP-------------------------------EELYN-IMMRCWKNRPEERPT-----FE-YIQSV--L---------
----YTTIRQLGDGTYGSVLLGRS---I----------------ESGE---LIAIKKMKRK--F-YSW---EE---C--MNLR----EVKSLKKL--N---HANVVKLKEVIR--E----------NDH------LYFIFEYMKE-NLYQLIK-------ERNK-----------------------------------------------------------------------------------------------------LF---PESAIRNIMYQILQGLAFIHK--H-----G---FFHRDLKPENLLCM-G-----PE-LV----KIADFGLARE----------IRSKPPY--------------TD---YVSTRWYRAPEVLL----RSTN---YSSPIDVWAVGCIMAEVYT-LR-PL---------------FPGA-----------SEIDTIFKI----CQ----VLG----TPKKTDWPEGYQLSSAMNFRWPQCV--PNNLKTLIPNASSEAVQ-LLRDMLQWDPKKRPT-----AS-QALRYPYF---------
----ITMSRELGQGSFGMVYEGVA---KG-----------VVKDEPET---RVAIKTVN-E--A-AS----MRE-RI-EFL-N----EASVMKEF--N---CHHVVRLLGVVS--Q----------GQP------TLVIMELMTRGDLKSYLR---------SLRPEM-----------------------------------------------------------------------------------------ENNPVL-APP---SLSKMIQMAGEIADGMAYLNA--N-----K---FVHRDLAARNCMVA-E-----DF-TV----KIGDFGMTRDI-----Y---E--TDYY--------------RKGGKGLLPVRWMSPESLK-----DGV---FTTYSDVWSFGVVLWEIATLAE-QP---------------YQGL-----------SNEQVLRFV----ME----GGL----LDKPDNCP-------------------------------DMLFE-LMRMCWQYNPKMRPS-----FL-EIISS--I---------
----ITLLRELGQGSFGMVYEGNA---RD-----------IIKGEAET---RVAVKTVN-E--S-AS----LRE-RI-EFL-N----EASVMKGF--T---CHHVVRLLGVVS--K----------GQP------TLVVMELMAHGDLKSYLR---------SLRPEA-----------------------------------------------------------------------------------------ENNPGR-PPP---TLQEMIQMAAEIADGMAYLNA--K-----K---FVHRDLAARNCMVA-H-----DF-TV----KIGDFGMTRDI-----Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGV---FTTSSDMWSFGVVLWEITSLAE-QP---------------YQGL-----------SNEQVLKFV----MD----GGY----LDQPDNCP-------------------------------ERVTD-LMRMCWQFNPKMRPT-----FL-EIVNLL-----------
---I-SIIRELGQGSFGMVYEGLA---RG-----------LEAGEEST---PVALKTVN-E--L-AS----PRE-CI-EFL-K----EASVMKAF--K---CHHVVRLLGVVS--Q----------GQP------TLVIMELMTRGDLKSHLR---------SLRPEA-----------------------------------------------------------------------------------------ENNPGL-PQP---ALGEMIQMAGEIADGMAYLAA--N-----K---FVHRDLAARNCMVS-Q-----DF-TV----KIGDFGMTRDV-----Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGI---FTTHSDVWSFGVVLWEIVTLAE-QP---------------YQGL-----------SNEQVLKFV----MD----GGV----LEELEGCP-------------------------------LQLQE-LMSRCWQPNPRLRPS-----FT-HILD---SI--------
-VGG----NKMGEGGFGVVYKGYV---N----------------NTT-----VAVKKLAAM--V-DIT---TE---ELKQQFD---QEIKVMAKC--Q---HENLVELLGFSS--D----------GDD------LCLVYVYMPNGSLLDRLSC-----LDGTP-----------------------------------------------------------------------------------------------------PL---SWHMRCKIAQGAANGINFLHE--N-----H---HIHRDIKSANILLD-E-----AF-TA----KISDFGLARASE-------KFAQTVMT--------------SR---IVGTTAYMAPEALR------GE---ITPKSDIYSFGVVLLEIIT-GL-PA---------------VDEH-----------REPQLLLDI----KE----EIE----DEEKTIEDYIDKKMNDAD-----------------STSVEAMYS-VASQCLHEKKNKRPD-----IK-KVQQ----LLQ------
----LTFVQEIGSGQFGLVHLGYW---L-----------------NKD---KVAIKTIR-E--G-AM----SE---E-DFI-E----EAEVMMKL--S---HPKLVQLYGVCL--E----------QAP------ICLVFEFMEHGCLSDYLR---------TQ--------------------------------------------------------------------------------------------------R-GLF---AAETLLGMCLDVCEGMAYLEE--A-----C---VIHRDLAARNCLVG-E-----NQ-VI----KVSDFGMTRFV---------L--DDQY--------------TSSTGTKFPVKWASPEVFS-----FSR---YSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR-----------SNSEVVEDI----ST----GFR----LYKPRLAS-------------------------------THVYQ-IMNHCWKERPEDRPA-----FS-RLLRQL-----------
---L-KRIRDLGEGHFGKVELCRY---DP------------EGDNTGE---QVAVKSLK-P--E-SG----GNH-IA-DLK-K----EIEILRNL--Y---HENIVKYKGICT-ED-----------GGN----GIKLIMEFLPSGSLKEYLP---------KN--------------------------------------------------------------------------------------------------K-NKI---NLKQQLKYAVQICKGMDYLGS--R-----Q---YVHRDLAARNVLVE-S-----EH-QV----KIGDFGLTKAI----ET---D--KEYY--------------TVKDDRDSPVFWYAPECLM-----QSK---FYIASDVWSFGVTLHELLTYCD-SDSSPMALF-LKMIGPTHGQM-----------TVTRLVNTL----KE----GKR----LPCPPNCP-------------------------------DEVYQ-LMRKCWEFQPSNRTS-----FQ-NLIE---GF--------
----LKFLQQLGKGNFGSVEMCRY---DP------------LQDNTGE---VVAVKKLQ-H--S-TE-----EH-LR-DFE-R----EIEILKSL--Q---HDNIVKYKGVCYSAG----------RRN------LKLIMEYLPYGSLRDYLQ---------KH--------------------------------------------------------------------------------------------------K-ERI---DHIKLLQYTSQICKGMEYLGT--K-----R---YIHRDLATRNILVE-N-----EN-RV----KIGDFGLTKVL----PQ---D--KEYY--------------KVKEPGESPIFWYAPESLT-----ESK---FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM-----------IVFHLIELL----KN----NGR----LPRPDGCP-------------------------------DEIYM-IMTECWNNNVNQRPS-----FR-DLA----LRV-------
---L-KYISQLGKGNFGSVELCRY---DP------------LGDNTGA---LVAVKQLQ-H--S-GP----DQ--QR-DFQ-R----EIQILKAL--H---SDFIVKYRGVSYGPG----------RQS------LRLVMEYLPSGCLRDFLQ---------RH--------------------------------------------------------------------------------------------------R-ARL---DASRLLLYSSQICKGMEYLGS--R-----R---CVHRDLAARNILVE-S-----EA-HV----KIADFGLAKLL----PL---D--KDYY--------------VVREPGQSPIFWYAPESLS-----DNI---FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDV-P---------ALCRLLELL----EE----GQR----LPAPPACP-------------------------------AEVHE-LMKLCWAPSPQDRPS-----FS-ALGP---QL--------
----LKLGKPLGRGAFGQVIEADA---FG-----------IDKTATCR---TVAVKMLK-E--G-AT----HSE-HR-ALM-S----ELKILIHIG-H---HLNVVNLLGACT-KP----------GGP------LMVIVEFCKFGNLSTYLR---------SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYK-DFL---TLEHLICYSFQVAKGMEFLAS--R-----K---CIHRDLAARNILLS-E-----KN-VV----KICDFGLARDI-----Y---K--DPDY--------------VRKGDARLPLKWMAPETIF-----DRV---YTIQSDVWSFGVLLWEIFSLGA-SP---------------YPGV-K---------IDEEFCRRL----KE----GTR----MRAPDYTT-------------------------------PEMYQ-TMLDCWHGEPSQRPT-----FS-ELVEHL-----------
----LSFGKTLGAGAFGKVVEATA---YG-----------LIKSDAAM---TVAVKMLK-P--S-AH----LTE-RE-ALM-S----ELKVLSYLG-N---HMNIVNLLGACT--I----------GGP------TLVITEYCCYGDLLNFLR---------RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDE-LAL---DLEDLLSFSYQVAKGMAFLAS--K-----N---CIHRDLAARNILLT-H-----GR-IT----KICDFGLARDI-----K---N--DSNY--------------VVKGNARLPVKWMAPESIF-----NCV---YTFESDVWSYGIFLWELFSLGS-SP---------------YPGM-P---------VDSKFYKMI----KE----GFR----MLSPEHAP-------------------------------AEMYD-IMKTCWDADPLKRPT-----FK-QIVQL--I---------
---V-TLLRALGHGAFGEVYEGLV---IG-----------LPGDSSPL---QVAIKTLP-E--L-CS----PQD-EL-DFL-M----EALIISKF--R---HQNIVRCVGLSL--R----------ATP------RLILLELMSGGDMKSFLR---------HSRP--------------------------------------------------------------------------------------------HLGQP-SPL---VMRDLLQLAQDIAQGCHYLEE--N-----H---FIHRDIAARNCLLS-CA--GPSR-VA----KIGDFGMARDI-----Y---R--ASYY--------------RRGDRALLPVKWMPPEAFL-----EGI---FTSKTDSWSFGVLLWEIFSLGY-MP---------------YPGR-----------TNQEVLDFV----VG----GGR----MDPPRGCP-------------------------------GPVYR-IMTQCWQHEPELRPS-----FA-SILERL-----------
----YTTMRQLGDGTYGSVLMGKS---N----------------ESGE---LVAIKRMKRK--F-YSW---DE---C-M-NLR----EVKSLKKL--N---HANVIKLKEVIR--E----------NDH------LYFIFEYMKE-NLYQLMK-------DRNK-----------------------------------------------------------------------------------------------------LF---PESVIRNIMYQILQGLAFIHK--H-----G---FFHRDMKPENLLCM-G-----PE-LV----KIADFGLARE----------LRSQPPY--------------TD---YVSTRWYRAPEVLL----RSSV---YSSPIDVWAVGSIMAELYM-LR-PL---------------FPGT-----------SEVDEIFKI----CQ----VLG----TPKKSDWPEGYQLASSMNFRFPQCV--PINLKTLIPNASNEAIQ-LMTEMLNWDPKKRPT-----AS-QALKHPYF---------
--WL--KGQQIGLGAFSSCYQAQD---V----------------GTGT---LMAVKQVTYV--R-NTS---SE---Q-EEVVEALREEIRMMSHL--N---HPNIIRMLGATC--E----------KSN------YNLFIEWMAGGSVAHLLS--------KYG-----------------------------------------------------------------------------------------------------AF---KESVVINYTEQLLRGLSYLHE--N-----Q---IIHRDVKGANLLID-S-----TG-QR---LRIADFGAAARLAS-----KGTGAGEFQ--------------GQ---LLGTIAFMAPEVLR-----GQQ---YGRSCDVWSVGCAIIEMAC-AK-PP---------------WNAE-----------KHSNHLALI----FK----IAS----ATTAPSIPSHLS---------------------------PGLRD-VALRCLELQPQDRPP-----SR-ELLKHPVF---------
-ERV-----VLGKGTYGIVYAGRD---L----------------SNQV---RIAIKEIPER--D-SRY---SQ---P-LH--E----EIALHKYL--K---HRNIVQYLGSVS--E----------NGY------IKIFMEQVPGGSLSALLR-------SKWG-----------------------------------------------------------------------------------------------------PM---KEPTIKFYTKQILEGLKYLHE--N-----Q---IVHRDIKGDNVLVNTY-----SG-VV----KISDFGTSKRL---------AGVNPCT--------------ET---FTGTLQYMAPEIID---QGPRG---YGAPADIWSLGCTIIEMAT-SK-PP---------------FHEL-------------GEPQAAM----FK----VGM----FKIHPEIPEALS---------------------------AEARA-FILSCFEPDPHKRAT-----TA-ELLREGF-L--------
---W-QRGNKIGEGQYGKVYTCIS---V----------------DTGE---LMAMKEIRFQ--P-NDH---KT---I-KETAD----ELKIFEGI--K---HPNLVRYFGVEL--H----------REE------MYIFMEYCDEGTLEEVS----------RL-----------------------------------------------------------------------------------------------------GL---QEHVIRLYSKQITIAINVLHE--H-----G---IVHRDIKGANIFLT-S-----SG-LI----KLGDFGCSVKLKN-----NAQTMPGEV--------------NS---TLGTAAYMAPEVITR--AKGEG---HGRAADIWSLGCVVIEMVT-GK-RP---------------WHEY------------EHNFQIMY----KV----GMG----HKPPIPERLS-----------------------------PEGKD-FLSHCLESDPKMRWT-----AS-QLLDHSFV---------
-DRV-----VLGKGTYGIVYAGRD---L----------------SNQV---RIAIKEIPER--D-SRY---SQ---P-LH--E----EIALHKHL--K---HKNIVQYLGSFS--E----------NGF------IKIFMEQVPGGSLSALLR-------SKWG-----------------------------------------------------------------------------------------------------PLK-DNEQTIGFYTKQILEGLKYLHD--N-----Q---IVHRDIKGDNVLINTY-----SG-VL----KISDFGTSKRL---------AGINPCT--------------ET---FTGTLQYMAPEIID---KGPRG---YGKAADIWSLGCTIIEMAT-GK-PP---------------FYEL-------------GEPQAAM----FK----VGM----FKVHPEIPESMS---------------------------AEAKA-FILKCFEPDPDKRAC-----AN-DLLVDEF-L--------
-ERL-----VLGKGTYGVVYAGRD---R----------------HTRV---RIAIKEIPER--D-SRF---SQ---P-LH--E----EIALHRRL--R---HKNIVRYLGSAS--Q----------GGY------LKIFMEEVPGGSLSSLLR-------SVWG-----------------------------------------------------------------------------------------------------PLK-DNESTISFYTRQILQGLGYLHD--N-----H---IVHRDIKGDNVLINTF-----SG-LL----KISDFGTSKRL---------AGITPCT--------------ET---FTGTLQYMAPEIID---QGPRG---YGKAADIWSLGCTVIEMAT-GR-PP---------------FHEL-------------GSPQAAM----FQ----VGM----YKVHPPMPSSLS---------------------------AEAQA-FLLRTFEPDPRLRAS-----AQ-TLLGDPFL---------
----IEVEEVVGRGAFGVVCKAKW---R------------------AK---DVAIKQIE-------S----ESE-RK-AFI-V----ELRQLSRV--N---HPNIVKLYGACL--------------NP------VCLVMEYAEGGSLYNVLH---------GA-------------------------------------------------------------------------------------------------EPLPYY---TAAHAMSWCLQCSQGVAYLHS--M-----QPKALIHRDLKPPNLLLV-A-----GGTVL----KICDFGTACDI---------------Q--------------THMTNNKGSAAWMAPEVFE-----GSN---YSEKCDVFSWGIILWEVITR-R-KP---------------FDEIGG---------PAFRIMWAV----HN----GTR----PPLIKNLP-------------------------------KPIES-LMTRCWSKDPSQRPS-----ME-EIVKI--M---------
----YTNLSYIGEGAYGMVCSAYD---N----------------VNKV---RVAIKKISPF--E-HQT---YC---Q-RT-LR----EIKILLRF--R---HENIIGINDIIR--APT-----IEQMKD------VYIVQDLMET-DLYKLLK---------TQ-----------------------------------------------------------------------------------------------------HL---SNDHICYFLYQILRGLKYIHS--A-----N---VLHRDLKPSNLLLN-T-----TC-DL----KICDFGLARVAD------PDHDHTGFL--------------TE---YVATRWYRAPEIML----NSKG---YTKSIDIWSVGCILAEMLS-NR-PI---------------FPGK-----------HYLDQLNHI----LG----ILG----SPSQEDLNCIINLKARNYLLSLPHKN-KVPWNRLFPNADSKALD-LLDKMLTFNPHKRIE-----VE-QALAHPYL---------
----YRDLQPVGSGAYGAVCSAVD---G----------------RTGA---KVAIKKLYRP--F-QSE---LF---A-KRAYR----ELRLLKHM--R---HENVIGLLDVFT--PDET----LDDFTD------FYLVMPFMGT-DLGKLMK---------HE-----------------------------------------------------------------------------------------------------KL---GEDRIQFLVYQMLKGLRYIHA--A-----G---IIHRDLKPGNLAVN-E-----DC-EL----KILDFGLAR------------QADSEM--------------TG---YVVTRWYRAPEVIL----NWMR---YTQTVDIWSVGCIMAEMIT-GK-TL---------------FKGS-----------DHLDQLKEI----MK----VTG----TPPAEFVQRLQSDEAKNYMKGLPELE-KKDFASILTNASPLAVN-LLEKMLVLDAEQRVT-----AG-EALAHPYF---------
----YEIIETIGNGAYGVVSSARR---R----------------LTGQ---QVAIKKIPNA--F-DVV---TN---A-KRTLR----ELKILKHF--K---HDNIIAIKDILR--PTVP----YGEFKS------VYVVLDLMES-DLHQIIH--------SSQ-----------------------------------------------------------------------------------------------------PL---TLEHVRYFLYQLLRGLKYMHS--A-----Q---VIHRDLKPSNLLVN-E-----NC-EL----KIGDFGMARGLCT-----SPAEHQYFM--------------TE---YVATRWYRAPELML----SLHE---YTQAIDLWSVGCIFGEMLA-RR-QL---------------FPGK-----------NYVHQLQLI----MM----VLG----TPSPAVIQAVGAERVRAYIQSLPPRQ-PVPWETVYPGADRQALS-LLGRMLRFEPSARIS-----AA-AALRHPFL---------
----YRLQKTIGKGNFAKVKLARH---V----------------LTGR---EVAVKIIDKT--Q-LNP---TS---L-QKLFR----EVRIMKIL--N---HPNIVKLFEVIE--T----------EKT------LYLVMEYASGGEVFDYLV--------AHG-----------------------------------------------------------------------------------------------------RM---KEKEARAKFRQIVSAVQYCHQ--K-----Y---IVHRDLKAENLLLD-G-----DM-NI----KIADFGFSNE----------FTVGNKL--------------DT---FCGSPPYAAPELFQ----GKKY---DGPEVDVWSLGVILYTLVS-GS-LP---------------FDGQ--------------NLKELR----ER----VLR----GKYRIPFYMS-----------------------------TDCEN-LLKKLLVLNPIKRGS-----LE-QIMKDRWM---------
---L-ILGKILGEGEFGSVMEGNL---K-------------QEDGTSL---KVAVKTMKLD--N-SS----QRE-IE-EFL-S----EAACMKDF--S---HPNVIRLLGVCI--E----------MSSQG-IPKPMVILPFMKYGDLHTYLL---------YSRL---------------------------------------------------------------------------------------------ETGP-KHI---PLQTLLKFMVDIALGMEYLSN--R-----N---FLHRDLAARNCMLR-D-----DM-TV----CVADFGLSKKI-----Y---S--GDYY--------------RQGRIAKMPVKWIAIESLA-----DRV---YTSKSDVWAFGVTMWEIATRGM-TP---------------YPGV-----------QNHEMYDYL----LH----GHR----LKQPEDCL-------------------------------DELYE-IMYSCWRTDPLDRPT-----FS-VLRLQ--L---------
----VHFNEVIGRGHFGCVYHGTL---L-------------DNDGKKI---HCAVKSLN-R--I-TD----IGE-VS-QFL-T----EGIIMKDF--S---HPNVLSLLGICL-RS----------EGS------PLVVLPYMKHGDLRNFIR---------NE--------------------------------------------------------------------------------------------------T-HNP---TVKDLIGFGLQVAKGMKYLAS--K-----K---FVHRDLAARNCMLD-E-----KF-TV----KVADFGLARDM-----Y---D--KEYYS------------VHNKTGAKLPVKWMALESLQ-----TQK---FTTKSDVWSFGVLLWELMTRGA-PP---------------YPDV-----------NTFDITVYL----LQ----GRR----LLQPEYCP-------------------------------DPLYE-VMLKCWHPKAEMRPS-----FS-ELVSR--I---------
-THS---DRVIGKGHFGVVYHGEY---I-------------DQAQNRI---QCAIKSLS-R--I-TE----MQQ-VE-AFL-R----EGLLMRGL--N---HPNVLALIGIML-PP----------EGL------PHVLLPYMCHGDLLQFIR---------SP--------------------------------------------------------------------------------------------------Q-RNP---TVKDLISFGLQVARSMEYLAE--Q-----K---FVHRDLAARNCMLD-E-----SF-TV----KVADFGLARDI-----L---D--REYYS------------VQQHRHARLPVKWMALESLQ-----TYR---FTTKSDVWSFGVLLWELLTRGA-PP---------------YRHI-----------DPFDLTHFL----AQ----GRR----LPQPEYCP-------------------------------DSLYQ-VMQQCWEADPAVRPT-----FR-VLV----GEV-------
---I-EYVRDIGEGAFGRVFQARA---PG-----------LLPYEPFT---MVAVKMLK-E--E-AS----ADM-QA-DFQ-R----EAALMAEF--D---NPNIVKLLGVCA--V----------GKP------MCLLFEYMAYGDLNEFLR---------SMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGP-PPL---SCAEQLCIARQVAAGMAYLSE--R-----K---FVHRDLATRNCLVG-E-----NM-VV----KIADFGLSRNI-----Y---S--ADYY--------------KANENDAIPIRWMPPESIF-----YNR---YTTESDVWAYGVVLWEIFSYGL-QP---------------YYGM-----------AHEEVIYYV----RD----GNI----LSCPENCP-------------------------------VELYN-LMRLCWSKLPADRPS-----FT-SIHRIL-----------
---Y-VRLQKIGEGSFGKAILVKS---T----------------EDGR---QYVIKEINIS--R-MSS---KE---R-EESRR----EVAVLANM--K---HPNIVQYRESFE--E----------NGS------LYIVMDYCEGGDLFKRINA------QKGV-----------------------------------------------------------------------------------------------------LF---QEDQILDWFVQICLALKHVHD--R-----K---ILHRDIKSQNIFLT-K-----DG-TV----QLGDFGIARVL---------NSTVELA--------------RT---CIGTPYYLSPEICE-----NKP---YNNKSDIWALGCVLYELCT-LK-HA---------------FEAG--------------SMKNLV----LK----IIS----GSFPPVSLHYS----------------------------YDLRS-LVSQLFKRNPRDRPS-----VN-SILEKGF-I--------
----YVLQQKLGSGSFGTVYLVSD---K----------------KAKRGEELKVLKEISVG--E-LNP---NE---T-VQANL----EAQLLSKL--D---HPAIVKFHASFV--E----------QDN------FCIITEYCEGRDLDDKIQEY----KQAGK-----------------------------------------------------------------------------------------------------IF---PENQIIEWFIQLLLGVDYMHE--R-----R---ILHRDLKSKNVFLK-------NN-LL----KIGDFGVSRLL---------MGSCDLA--------------TT---LTGTPHYMSPEALK-----HQG---YDTKSDIWSLACILYEMCC-MN-HA---------------FAGS--------------NFLSIV----LK----IVE----GDTPSLPERY-P---------------------------KELNA-IMESMLNKNPSLRPS-----AI-EILKIPYL---------
----YEVLYTIGTGSYGRCQKIRR---K----------------SDGK---ILVWKELDYG--S-MTE---AE---K-QMLVS----EVNLLREL--K---HPNIVRYYDRII--DR--------TNTT------LYIVMEYCEGGDLASVITKG----TKERQ-----------------------------------------------------------------------------------------------------YL---DEEFVLRVMTQLTLALKECHR--RSDGGHT---VLHRDLKPANVFLD-G-----KQ-NV----KLGDFGLARIL---------NHDTSFA--------------KT---FVGTPYYMSPEQMN-----RMS---YNEKSDIWSLGCLLYELCA-LM-PP---------------FTAF--------------SQKELA----GK----IRE----GKFRRIPYRY---S-------------------------DELNE-IITRMLNLKDYHRPS-----VE-EILENPL-I--------
---Y-CYLRVVGKGSYGEVTLVKH---R----------------RDGK---QYVIKKLNLR--N-ASS---RE---R-RAAEQ----EAQLLSQL--K---HPNIVTYKESWE--G---------GDGL------LYIVMGFCEGGDLYRKLKE------QKGQ-----------------------------------------------------------------------------------------------------LL---PENQVVEWFVQIAMALQYLHE--K-----H---ILHRDLKTQNVFLT-R-----TN-II----KVGDLGIARVL---------ENHCDMA--------------ST---LIGTPYYMSPELFS-----NKP---YNYKSDVWALGCCVYEMAT-LK-HA---------------FNAK--------------DMNSLV----YR----IIE----GKLPPMPRDY---S-------------------------PELAE-LIRTMLSKRPEERPS-----VR-SILRQPYI---------
----YDVIKAIGQGAFGKAYLAKG---K----------------SDSK---HCVIKEINFE--K-MPI---QE---K-EASKK----EVILLEKM--K---HPNIVAFFNSFQ--E----------NGR------LFIVMEYCDGGDLMKRINR------QRGV-----------------------------------------------------------------------------------------------------LF---SEDQILGWFVQISLGLKHIHD--R-----K---ILHRDIKAQNIFLS-K-----NG-MV---AKLGDFGIARVL---------NNSMELA--------------RT---CIGTPYYLSPEICQ-----NKP---YNNKTDIWSLGCVLYELCT-LK-HP---------------FEGN--------------NLQQLV----LK----ICQ----AHFAPISPGF---S-------------------------RELHS-LISQLFQVSPRDRPS-----IN-SILKRPFL---------
----FRIEKKIGRGQFSEVYRAAC---L----------------LDGV---PVALKKVQIF--D-LMD---AK---A-RADCI---KEIDLLKQL--N---HPNVIKYYASFI--E----------DNE------LNIVLELADAGDLSRMIKHF----KKQKR-----------------------------------------------------------------------------------------------------LI---PERTVWKYFVQLCSALEHMHS--R-----R---VMHRDIKPANVFIT-A-----TG-VV----KLGDLGLGRFF---------SSKTTAA--------------HS---LVGTPYYMSPERIH-----ENG---YNFKSDIWSLGCLLYEMAA-LQ-SP---------------FYGD------------KMNLYSLC----KK----IEQ----CDYPPLPSDHYS---------------------------EELRQ-LVNMCINPDPEKRPD-----VT-YV------YDVA-----
----YERIRVVGRGAFGIVHLCLR---K----------------ADQK---LVIIKQIPVE--Q-MTK---EE---R-QAAQN----ECQVLKLL--N---HPNVIEYYENFL--E----------DKA------LMIAMEYAPGGTLAEFIQK------RCNS-----------------------------------------------------------------------------------------------------LL---EEETILHFFVQILLALHHVHT--H-----L---ILHRDLKTQNILLDKH-----RM-VV----KIGDFGISKI----------LSSKSKA--------------YT---VVGTPCYISPELCE-----GKP---YNQKSDIWALGCVLYELAS-LK-RA---------------FEAA--------------NLPALV----LK----IMS----GTFAPISDRY---S-------------------------PELRQ-LVLSLLSLEPAQRPP-----LS-HIMAQP--LC-------
--IV--LKWELGEGAFGKVFLAEC---HN-----------LLPEQDKM---LVAVKALK-E--A-SE----SA--RQ-DFQ-R----EAELLTML--Q---HQHIVRFFGVCT--E----------GRP------LLMVFEYMRHGDLNRFLR---------SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAP-GPL---GLGQLLAVASQVAAGMVYLAG--L-----H---FVHRDLATRNCLVG-Q-----GL-VV----KIGDFGMSRDI-----Y---S--TDYY--------------RVGGRTMLPIRWMPPESIL-----YRK---FTTESDVWSFGVVLWEIFTYGK-QP---------------WYQL-----------SNTEAIDCI----TQ----GRE----LERPRACP-------------------------------PEVYA-IMRGCWQREPQQRHS-----IK-DVHARL-----------
---I-VLKRELGEGAFGKVFLAEC---YN-----------LCPEQDKI---LVAVKTLK-D--A-SD----NA--RK-DFH-R----EAELLTNL--Q---HEHIVKFYGVCV--E----------GDP------LIMVFEYMKHGDLNKFLR---------AHGPDAV--------------------------------------------------------------------------------------LMAEGNPP-TEL---TQSQMLHIAQQIAAGMVYLAS--Q-----H---FVHRDLATRNCLVG-E-----NL-LV----KIGDFGMSRDV-----Y---S--TDYY--------------RVGGHTMLPIRWMPPESIM-----YRK---FTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL-----------SNNEVIECI----TQ----GRV----LQRPRTCP-------------------------------QEVYE-LMLGCWQREPHMRKN-----IK-GIHTL--L---------
---I-VLKRELGEGAFGKVFLAEC---YN-----------LSPTKDKM---LVAVKALK-D--P-TL----AA--RK-DFQ-R----EAELLTNL--Q---HEHIVKFYGVCG--D----------GDP------LIMVFEYMKHGDLNKFLR---------AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAK-GEL---GLSQMLHIASQIASGMVYLAS--Q-----H---FVHRDLATRNCLVG-A-----NL-LV----KIGDFGMSRDV-----Y---S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----YRK---FTTESDVWSFGVILWEIFTYGK-QP---------------WFQL-----------SNTEVIECI----TQ----GRV----LERPRVCP-------------------------------KEVYD-VMLGCWQREPQQRLN-----IK-EIYKIL-----------
----YELQEVIGSGATAVVQAAYC---A----------------PKKE---KVAIKRINLE--K-CQT---SM---D-E-LLK----EIQAMSQC--H---HPNIVSYYTSFV--V----------KDE------LWLVMKLLSGGSVLDIIKHIVAKGEHKSG-----------------------------------------------------------------------------------------------------VL---DESTIATILREVLEGLEYLHK--N-----G---QIHRDVKAGNILLG-E-----DG-SV----QIADFGVSAFLAT----GGDITRNKVR--------------KT---FVGTPCWMAPEVME----QVRG---YDFKADIWSFGITAIELAT-GA-AP---------------YHKY-----------PPMKVLMLT----LQ----NDP----PSLETGVQDKE--MLK--------------------KYGKSFRK-MISLCLQKDPEKRPT-----AA-ELLRHKFF---------
----YTRFEKIGQGASGTVYTAMD---V----------------ATGQ---EVAIKQMNLQ--Q-QPK---KE---L-II--N----EILVMREN--K---NPNIVNYLDSYL--V----------GDE------LWVVMEYLAGGSLTDVVT---------ET-----------------------------------------------------------------------------------------------------CM---DEGQIAAVCRECLQALEFLHS--N-----Q---VIHRDIKSDNILLG-M-----DG-SV----KLTDFGFCAQI---------TPEQSKR--------------ST---MVGTPYWMAPEVVT-----RKA---YGPKVDIWSLGIMAIEMIE-GE-PP---------------YLNE-----------NPLRALYLI----AT----NGT----PELQNPEKLS-----------------------------AIFRD-FLNRCLEMDVEKRGS-----AK-ELLQHQFL---------
----YTRYEKIGQGASGTVFTATD---V----------------ALGQ---EVAIKQINLQ--K-QPK---KE---L-II--N----EILVMKEL--K---NPNIVNFLDSYL--V----------GDE------LFVVMEYLAGGSLTDVVT---------ET-----------------------------------------------------------------------------------------------------CM---DEAQIAAVCRECLQALEFLHA--N-----Q---VIHRDIKSDNVLLG-M-----EG-SV----KLTDFGFCAQI---------TPEQSKR--------------ST---MVGTPYWMAPEVVT-----RKA---YGPKVDIWSLGIMAIEMVE-GE-PP---------------YLNE-----------NPLRALYLI----AT----NGT----PELQNPEKLS-----------------------------PIFRD-FLNRCLEMDVEKRGS-----AK-ELLQHPFL---------
----YTRFEKIGQGASGTVYTALD---I----------------ATGQ---EVAIKQMNLQ--Q-QPK---KE---L-II--N----EILVMREN--K---NPNIVNYLDSYL--V----------GDE------LWVVMEYLAGGSLTDVVT---------ET-----------------------------------------------------------------------------------------------------CM---DEGQIAAVCRECLQALDFLHS--N-----Q---VIHRDIKSDNILLG-M-----DG-SV----KLTDFGFCAQI---------TPEQSKR--------------ST---MVGTPYWMAPEVVT-----RKA---YGPKVDIWSLGIMAIEMVE-GE-PP---------------YLNE-----------NPLRALYLI----AT----NGT----PELQNPERLS-----------------------------AVFRD-FLNRCLEMDVDRRGS-----AK-ELLQHPFL---------
DNFI-----KIGEGSTGIVCIATV---R----------------SSGK---LVAVKKMDLR--K-QQR---RE---L---LFN----EVVIMRDY--Q---HENVVEMYNSYL--V----------GDE------LWVVMEFLEGGALTDIVT---------HT-----------------------------------------------------------------------------------------------------RM---NEEQIAAVCLAVLQALSVLHA--Q-----G---VIHRDIKSDSILLT-H-----DG-RV----KLSDFGFCAQV---------SKEVPRR--------------KS---LVGTPYWMAPELIS-----RLP---YGPEVDIWSLGIMVIEMVD-GE-PP---------------YFNE-----------PPLKAMKMI----RD----NLP----PRLKNLHKVS-----------------------------PSLKG-FLDRLLVRDPAQRAT-----AA-ELLKHPFL---------
ANFI-----KIGEGSTGIVCIATE---K----------------HTGK---QVAVKKMDLR--K-QQR---RE---L---LFN----EVVIMRDY--H---HDNVVDMYSSYL--V----------GDE------LWVVMEFLEGGALTDIVT---------HT-----------------------------------------------------------------------------------------------------RM---NEEQIATVCLSVLRALSYLHN--Q-----G---VIHRDIKSDSILLT-S-----DG-RI----KLSDFGFCAQV---------SKEVPKR--------------KS---LVGTPYWMAPEVIS-----RLP---YGTEVDIWSLGIMVIEMID-GE-PP---------------YFNE-----------PPLQAMRRI----RD----SLP----PRVKDLHK----VS-------------------------SVLRG-FLDLMLVREPSQRAT-----AQ-ELLGHPFL---------
---Y-IKLDKLGEGTYATVYKGKS---K----------------LTDN---LVALKEIRLE--H-EEG---AP---C--TAIR----EVSLLKDL--K---HANIVTLHDIIH--T----------EKS------LTLVFEYLDK-DLKQYLD-------DCGN-----------------------------------------------------------------------------------------------------II---NMHNVKLFLFQLLRGLAYCHR--Q-----K---VLHRDLKPQNLLIN-E-----RG-EL----KLADFGLARAK---------SIPTKTY--------------SN---EVVTLWYRPPDILL----GSTD---YSTQIDMWGVGCIFYEMAT-GR-PL---------------FPGS-----------TVEEQLHFI----FR----ILG----TPTEETWPGILSNEEFKTYNYPKYR--AEALLSHAPRLDSDGAD-LLTKLLQFEGRNRIS-----AE-DAMKHPFF---------
---Y-IKLEKLGEGTYATVYKGRS---K----------------LTEN---LVALKEIRLE--H-EEG---AP---C--TAIR----EVSLLKDL--K---HANIVTLHDIVH--T----------DKS------LTLVFEYLDK-DLKQYMD-------DCGN-----------------------------------------------------------------------------------------------------IM---SMHNVKLFLYQILRGLAYCHR--R-----K---VLHRDLKPQNLLIN-E-----KG-EL----KLADFGLARAK---------SVPTKTY--------------SN---EVVTLWYRPPDVLL----GSSE---YSTQIDMWGVGCIFFEMAS-GR-PL---------------FPGS-----------TVEDELHLI----FR----LLG----TPSQETWPGISSNEEFKNYNFPKYK--PQPLINHAPRLDSEGIE-LITKFLQYESKKRVS-----AE-EAMKHVYF---------
----YVKLDKLGEGTYATVFKGRS---K----------------LTEN---LVALKEIRLE--H-EEG---AP---C--TAIR----EVSLLKNL--K---HANIVTLHDLIH--T----------DRS------LTLVFEYLDS-DLKQYLD--------HCG-----------------------------------------------------------------------------------------------------NL--MSMHNVKIFMFQLLRGLAYCHH--R-----K---ILHRDLKPQNLLIN-E-----RG-EL----KLADFGLARAK---------SVPTKTY--------------SN---EVVTLWYRPPDVLL----GSTE---YSTPIDMWGVGCIHYEMAT-GR-PL---------------FPGS-----------TVKEELHLI----FR----LLG----TPTEETWPGVTAFSEFRTYSFPCYL--PQPLINHAPRLDTDGIH-LLSSLLLYESKSRMS-----AE-AALSHSYF---------
---L-VLGRVLGSGAFGKVVEGTA---YG-----------LSRSQPVM---KVAVKMLK-P--T-AR----SSE-KQ-ALM-S----ELKIMTHLG-P---HLNIVNLLGACT--K----------SGP------IYIITEYCFYGDLVNYLH---------KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNS-EGL---TLLDLLSFTYQVARGMEFLAS--K-----N---CVHRDLAARNVLLA-Q-----GK-IV----KICDFGLARDI-----M---H--DSNY--------------VSKGSTFLPVKWMAPESIF-----DNL---YTTLSDVWSYGILLWEIFSLGG-TP---------------YPGM-M---------VDSTFYNKI----KS----GYR----MAKPDHAT-------------------------------SEVYE-IMVKCWNSEPEKRPS-----FY-HLSE---IV--------
---L-VLGRTLGSGAFGQVVEATA---HG-----------LSHSQATM---KVAVKMLK-S--T-AR----SSE-KQ-ALM-S----ELKIMSHLG-P---HLNVVNLLGACT--K----------GGP------IYIITEYCRYGDLVDYLH---------RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINES-PVL---SYMDLVGFSYQVANGMEFLAS--K-----N---CVHRDLAARNVLIC-E-----GK-LV----KICDFGLARDI-----M---R--DSNY--------------ISKGSTFLPLKWMAPESIF-----NSL---YTTLSDVWSFGILLWEIFTLGG-TP---------------YPEL-P---------MNEQFYNAI----KR----GYR----MAQPAHAS-------------------------------DEIYE-IMQKCWEEKFEIRPP-----FS-QLVL---LL--------
----YEKLEKLGEGSYATVYKGKS---K----------------VNGK---LVALKVIRLQ--E-EEG---TP---F--TAIR----EASLLKGL--K---HANIVLLHDIIH--T----------KET------LTLVFEYVHT-DLCQYMD-------KHPG-----------------------------------------------------------------------------------------------------GL---HPDNVKLFLFQLLRGLSYIHQ--R-----Y---ILHRDLKPQNLLIS-D-----TG-EL----KLADFGLARAK---------SVPSHTY--------------SN---EVVTLWYRPPDVLL----GSTE---YSTCLDMWGVGCIFVEMIQ-GV-AA---------------FPGM----------KDIQDQLERI----FL----VLG----TPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAED-LASKLLQCSPKNRLS-----AQ-AALSHEYF---------
--FR--CCAVLGRGHFGKVLLAEY---K----------------NTNE---MFAIKALKKG--D-IVA---RD---E-VDSLM---CEKRIFETV--NSVRHPFLVNLFACFQ--T----------KEH------VCFVMEYAAGGDLMMHIH---------TD-----------------------------------------------------------------------------------------------------VF---SEPRAVFYAACVVLGLQYLHE--H-----K---IVYRDLKLDNLLLD-T-----EG-FV----KIADFGLCKEG---------MGYGDRT--------------ST---FCGTPEFLAPEVLT-----ETS---YTRAVDWWGLGVLIYEMLV-GE-SP---------------FPGD--------------DEEEVF----DS----IVN----DEVRYPRFLS-----------------------------TEAIS-IMRRLLRRNPERRLGASEKDAE-DVKKHPFF---------
---F-ERIKTLGTGSFGRVMLVKH---K----------------ETGN---HYAMKILDKQ--K-VVK---LK---Q-IEHTL---NEKRILQAV--N---FPFLVKLEFSFK--D----------NSN------LYMVMEYVPGGEMFSHLR--------RIG-----------------------------------------------------------------------------------------------------RF---SEPHARFYAAQIVLTFEYLHS--L-----D---LIYRDLKPENLLID-Q-----QG-YI----QVTDFGFAK------------RVKGRT--------------WT---LCGTPEYLAPEIIL-----SKG---YNKAVDWWALGVLIYEMAA-GY-PP---------------FFAD--------------QPIQIY----EK----IVS----GKVRFPSHFS-----------------------------SDLKD-LLRNLLQVDLTKRFGNLKNGVN-DIKNHKWF---------
---F-ERKKTLGTGSFGRVMLVKH---K----------------ATEQ---YYAMKILDKQ--K-VVK---LK---Q-IEHTL---NEKRILQAV--N---FPFLVRLEYAFK--D----------NSN------LYMVMEYVPGGEMFSHLR--------RIG-----------------------------------------------------------------------------------------------------RF---SEPHARFYAAQIVLTFEYLHS--L-----D---LIYRDLKPENLLID-H-----QG-YI----QVTDFGFAK------------RVKGRT--------------WT---LCGTPEYLAPEIIL-----SKG---YNKAVDWWALGVLIYEMAA-GY-PP---------------FFAD--------------QPIQIY----EK----IVS----GKVRFPSHFS-----------------------------SDLKD-LLRNLLQVDLTKRFGNLKNGVS-DIKTHKWF---------
----FERLRTLGMGSFGRVMLVRH---Q----------------ETGG---HYAMKILNKQ--K-VVK---MK---Q-VEHIL---NEKRILQAI--D---FPFLVKLQFSFK--D----------NSY------LYLVMEYVPGGEMFSRLQ--------RVG-----------------------------------------------------------------------------------------------------RF---SEPHACFYAAQVVLAVQYLHS--L-----D---LIHRDLKPENLLID-Q-----QG-YL----QVTDFGFAK------------RVKGRT--------------WT---LCGTPEYLAPEIIL-----SKG---YNKAVDWWALGVLIYEMAV-GF-PP---------------FYAD--------------QPIQIY----EK----IVS----GRVRFPSKLS-----------------------------SDLKH-LLRSLLQVDLTKRFGNLRNGVG-DIKNHKWF---------
--FI--FHKVLGKGSFGKVLLGEL---K----------------GRGE---YFAIKALKKD--V-VLI---DD---D-VECTM---VEKRVLTLA-AE---NPFLTHLICTFQ--T----------KDH------LFFVMEFLNGGDLMYHIQ--------DKG-----------------------------------------------------------------------------------------------------RF---ELYRATFYAAEIMCGLQFLHS--K-----G---IIYRDLKLDNVLLD-R-----DG-HI----KIADFGMCKEN---------IFGESRA--------------ST---FCGTPDYIAPEILQ-----GLK---YTFSVDWWSFGVLLYEMLI-GQ-SP---------------FHGD--------------DEDELF----ES----IRV----DTPHYPRWIT-----------------------------KESKD-ILEKLFEREPTKRLG----VTG-NIKIHPFF---------
--FI--LHKMLGKGSFGKVFLAEF---K----------------KTNQ---FFAIKALKKD--V-VLM---DD---D-VECTM---VEKRVLSLA-WE---HPFLTHMFCTFQ--T----------KEN------LFFVMEYLNGGDLMYHIQ--------SCH-----------------------------------------------------------------------------------------------------KF---DLSRATFYAAEIILGLQFLHS--K-----G---IVYRDLKLDNILLD-K-----DG-HI----KIADFGMCKEN---------MLGDAKT--------------NT---FCGTPDYIAPEILL-----GQK---YNHSVDWWSFGVLLYEMLI-GQ-SP---------------FHGQ--------------DEEELF----HS----IRM----DNPFYPRWLE-----------------------------KEAKD-LLVKLFVREPEKRLG-----VRGDIRQHPLF---------
--PD----EVLGSGQFGIVYGGKH---R----------------KTGR---DVAIKIIDKL--R-FPT---KQ---E-SQLRN----EVAILQNL--H---HPGVVNLECMFE--T----------PER------VFVVMEKLHGDMLEMILS-------SEKG-----------------------------------------------------------------------------------------------------RL---PEHITKFLITQILVALRHLHF--K-----N---IVHCDLKPENVLLA-S-----AD-PFP-QVKLCDFGFARI----------IGEKSFR--------------RS---VVGTPAYLAPEVLR-----NKG---YNRSLDMWSVGVIIYVSLS-GT-FP---------------FNED----------------EDIH----DQ----IQN----AAFMYPPNPWKEIS-------------------------HEAID-LINNLLQVKMRKRYS-----VD-KTLSHPWL---------
--PD----EVLGSGQFGVVYGGKH---R----------------KTGR---DVAVKVIDKL--R-FPT---KQ---E-SQLRN----EVAILQSL--R---HPGIVNLECMFE--T----------PEK------VFVVMEKLHGDMLEMILS-------SEKG-----------------------------------------------------------------------------------------------------RL---PERLTKFLITQILVALRHLHF--K-----N---IVHCDLKPENVLLA-S-----AD-PFP-QVKLCDFGFARI----------IGEKSFR--------------RS---VVGTPAYLAPEVLL-----NQG---YNRSLDMWSVGVIMYVSLS-GT-FP---------------FNED----------------EDIN----DQ----IQN----AAFMYPASPWSHIS-------------------------AGAID-LINNLLQVKMRKRYS-----VD-KSLSHPWL---------
-FAD----EVLGSGQFGIVYGGKH---R----------------KTGR---DVAIKVIDKM--R-FPT---KQ---E-SQLRN----EVAILQNL--H---HPGIVNLECMFE--T----------PER------VFVVMEKLHGDMLEMILS-------SEKS-----------------------------------------------------------------------------------------------------RL---PERITKFMVTQILVALRNLHF--K-----N---IVHCDLKPENVLLA-S-----AE-PFP-QVKLCDFGFARI----------IGEKSFR--------------RS---VVGTPAYLAPEVLR-----SKG---YNRSLDMWSVGVIIYVSLS-GT-FP---------------FNED----------------EDIN----DQ----IQN----AAFMYPPNPWREIS-------------------------GEAID-LINNLLQVKMRKRYS-----VD-KSLSHPWL---------
---L-EIIATLGVGGFGRVELVKV---K----------------NENV---AFAMKCIRKK--H-IVD---TK---Q-QEHVY---SEKRILEEL--C---SPFIVKLYRTFK--D----------NKY------VYMLLEACLGGELWSILR--------DRG-----------------------------------------------------------------------------------------------------SF---DEPTSKFCVACVTEAFDYLHR--L-----G---IIYRDLKPENLILD-A-----EG-YL----KLVDFGFAKK----------IGSGQKT--------------WT---FCGTPEYVAPEVIL-----NKG---HDFSVDFWSLGILVYELLT-GN-PP---------------FSGV--------------DQMMTY----NL----ILK----GIEKMDFPRKIT---------------------------RRPED-LIRRLCRQNPTERLGNLKNGIN-DIKKHRWL---------
--FD--TLATVGTGTFGRVHLVKE---K----------------TAKH---FFALKVMSIP--D-VIR---LK---Q-EQHVH---NEKSVLKEV--S---HPFLIRLFWTWH--D----------ERF------LYMLMEYVPGGELFSYLR--------NRG-----------------------------------------------------------------------------------------------------RF---SSTTGLFYSAEIICAIEYLHS--K-----E---IVYRDLKPENILLD-R-----DG-HI----KLTDFGFAKK------------LVDRT--------------WT---LCGTPEYLAPEVIQ-----SKG---HGRAVDWWALGILIFEMLS-GF-PP---------------FFDD--------------NPFGIY----QK----ILA----GKIDFPRHLD-----------------------------FHVKD-LIKKLLVVDRTRRLGNMKNGAN-DVKHHRWF---------
---F-TLCRKLGSGYFGEVFEGLW---K-----------------DRV---QVAIKVIS-R--D-NL----LH--QQ-MLQ-S----EIQAMKKL--R---HKHILALYAVVS--V----------GDP------VYIITELMAKGSLLELLR---------DS-------------------------------------------------------------------------------------------------DE-KVL---PVSELLDIAWQVAEGMCYLES--Q-----N---YIHRDLAARNILVG-E-----NT-LC----KVGDFGLARLI------------KEDV--------------YLSHDHNIPYKWTAPEALS-----RGH---YSTKSDVWSFGILLHEMFSRGQ-VP---------------YPGM-----------SNHEAFLRV----DA----GYR----MPCPLECP-------------------------------PSVHK-LMLTCWCRDPEQRPC-----FK-ALRERL-----------
--VM--LSTRIGSGSFGTVYKGKW---H-------------------G---DVAVKILK-V-VD-PT----PEQ-FQ-AFR-N----EVAVLRKT--R---HVNILLFMGYMT-------------KDN------LAIVTQWCEGSSLYKHLH---------VQ--------------------------------------------------------------------------------------------------E-TKF---QMFQLIDIARQTAQGMDYLHA--K-----N---IIHRDMKSNNIFLH-E-----GL-TV----KIGDFGLATVK-----S---R--WSGS--------------QQVEQPTGSVLWMAPEVIR-----MQDNNPFSFQSDVYSYGIVLYELMT-GE-LP---------------YSHI-N---------NRDQIIFMV----GR----GYASPDLSKLYKNCP-------------------------------KAMKR-LVADCVKKVKEERPL-----FP-QILSS--I---------
---L-VLGKTLGEGEFGKVVKATA---FH-----------LKGRAGYT---TVAVKMLK-E--N-AS----PSE-LR-DLL-S----EFNVLKQV--N---HPHVIKLYGACS--Q----------DGP------LLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDE-RAL---TMGDLISFAWQISQGMQYLAE--M-----K---LVHRDLAARNILVA-E-----GR-KM----KISDFGLSRDV-----Y---E--EDSY--------------VKRSQGRIPVKWMAIESLF-----DHI---YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI-----------PPERLFNLL----KT----GHR----MERPDNCS-------------------------------EEMYR-LMLQCWKQEPDKRPV-----FA-DISKDL-----------
-LAD---LRYLSRGASGTVSSARH---A----------------DWRV---QVAVKHLHIH--T-PLL---DS---E-RKDVL---REAEILHKA--R---FSYILPILGICN--E----------PEF------LGIVTEYMPNGSLNELLH--------RKT-----------------------------------------------------------------------------------------------------EYPDVAWPLRFRILHEIALGVNYLHN--MT---PP---LLHHDLKTQNILLD-N-----EF-HV----KIADFGLSKWRMM----SLSQSRSSKS--------------AP---EGGTIIYMPPENYEP--GQKSR---ASIKHDIYSYAVITWEVLS-RK-QP---------------FEDVT---------NPLQIMYSVS----QG----HRP----VINEESLPYDIPHR-------------------------ARMIS-LIESGWAQNPDERPS-----FL-KCL-----IEL------
FTGW----EKVGSGGFGQVYKVRH---V----------------HWKT---WLAIKCSPSL--H-VDD---RE---R-MELLE----EAKKMEMA--K---FRYILPVYGIC--------------REP------VGLVMEYMETGSLEKLLA---------SE-----------------------------------------------------------------------------------------------------PL---PWDLRFRIIHETAVGMNFLHC--MA---PP---LLHLDLKPANILLD-A-----HY-HV----KISDFGLAKCNG------LSHSHDLSM--------------DG---LFGTIAYLPPERIR---EKSRL---FDTKHDVYSFAIVIWGVLT-QK-KP---------------FADE----------KNILHIMVKV----VK----GHR----PELPPVCRARPRAC-------------------------SHLIR-LMQRCWQGDPRVRPT-----FQ---------GNGLN----
--LT--LRLLLGSGAFGEVYEGTA---VDI----------LGVGSGEI---KVAVKTLK-K--G-ST----DQE-KI-EFL-K----EAHLMSKF--N---HPNILKQLGVCL--L----------NEP------QYIILELMEGGDLLTYLR---------KARM--------------------------------------------------------------------------------------------ATFYG-PLL---TLVDLVDLCVDISKGCVYLER--M-----H---FIHRDLAARNCLVS-VKDYTSPR-IV----KIGDFGLARDI-----Y---K--NDYY--------------RKRGEGLLPVRWMAPESLM-----DGI---FTTQSDVWSFGILIWEILTLGH-QP---------------YPAH-----------SNLDVLNYV----QT----GGR----LEPPRNCP-------------------------------DDLWN-LMTQCWAQEPDQRPT-----FH-RIQDQL-----------
----FELLRVLGKGGYGKVFQVRKVTGA----------------NTGK---IFAMKVLKKA--M-IVR---NA---K-DTAHTK--AERNILEEV--K---HPFIVDLIYAFQ--T----------GGK------LYLILEYLSGGELFMQLE--------REG-----------------------------------------------------------------------------------------------------IF---MEDTACFYLAEISMALGHLHQ--K-----G---IIYRDLKPENIMLN-H-----QG-HV----KLTDFGLCKES---------IHDGTVT--------------HT---FCGTIEYMAPEILM-----RSG---HNRAVDWWSLGALMYDMLT-GA-PP---------------FTGE--------------NRKKTI----DK----ILK----CKLNLPPYLT-----------------------------QEARD-LLKKLLKRNAASRLGAGPGDAG-EVQAHPFF---------
----FELLRVLGKGGYGKVFQVRK---V----------------QGTNLGKIYAMKVLRKA--K-IVR---NA---K-DTAHTR--AERNILESV--K---HPFIVELAYAFQ--T----------GGK------LYLILECLSGGELFTHLE--------REG-----------------------------------------------------------------------------------------------------IF---LEDTACFYLAEITLALGHLHS--Q-----G---IIYRDLKPENIMLS-S-----QG-HI----KLTDFGLCKES---------IHEGAVT--------------HT---FCGTIEYMAPEILV-----RSG---HNRAVDWWSLGALMYDMLT-GS-PP---------------FTAE--------------NRKKTM----DK----IIR----GKLALPPYLT-----------------------------PDARD-LVKKFLKRNPSQRIGGGPGDAA-DVQRHPFF---------
----WEIIGELGDGAFGKVYKAQN---K----------------ETSV---LAAAKVIDTK--S-EEE---LE---D-YM--V----EIDILASC--D---HPNIVKLLDAFY--Y----------ENN------LWILIEFCAGGAVDAVML-------ELER-----------------------------------------------------------------------------------------------------PL---TESQIQVVCKQTLDALNYLHD--N-----K---IIHRDLKAGNILFT-L-----DG-DI----KLADFGVSAKN---------TRTIQRR--------------DS---FIGTPYWMAPEVVMCETSKDRP---YDYKADVWSLGITLIEMAE-IE-PP---------------HHEL-----------NPMRVLLKI----AK----SEP----PTLAQPSRWS-----------------------------SNFKD-FLKKCLEKNVDARWT-----TS-QLLQHPFV---------
---L-RLEVKLGQGCFGEVWMGTW---N-----------------GTT---RVAIKTLK-P--G-TM----SP---E-AFL-Q----EAQVMKKL--R---HEKLVQLYAVVS-------------EEP------IYIVTEYMSKGSLLDFLK---------GE-------------------------------------------------------------------------------------------------TG-KYL---RLPQLVDMAAQIASGMAYVER--M-----N---YVHRDLRAANILVG-E-----NL-VC----KVADFGLARLI---------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM-----------VNREVLDQV----ER----GYR----MPCPPECP-------------------------------ESLHD-LMCQCWRKEPEERPT-----FE-YLQAF--L---------
--FA--LGRKLGEGYFGEVWEGLW---L-----------------GSL---PVAIKVIK-S--A-NM----K---LT-DLA-K----EIQTLKGL--R---HERLIRLHAVCS--G----------GEP------VYIVTELMRKGNLQAFLG---------TP-------------------------------------------------------------------------------------------------EG-RAL---RLPPLLGFACQVAEGMSYLEE--Q-----R---VVHRDLAARNVLVD-D-----GL-AC----KVADFGLARLL---------K--DDIY--------------SPSSSSKIPVKWTAPEAAN-----YRV---FSQKSDVWSFGVLLHEVFTYGQ-CP---------------YEGM-----------TNHETLQQI----MR----GYR----LPRPAACP-------------------------------AEVYV-LMLECWRSSPEERPS-----FA-TLREKL-----------
----FTKLEKIGKGSFGEVFKGID---N----------------RTQK---VVAIKIIDLE--E-AED---EI---E-DIQ-Q----EITVLSQC--D---SPYVTKYYGSYL--K----------DTK------LWIIMEYLGGGSALDLLE---------PG-----------------------------------------------------------------------------------------------------PL---DETQIATILREILKGLDYLHS--E-----K---KIHRDIKAANVLLS-E-----HG-EV----KLADFGVAGQL---------TDTQIKR--------------NT---FVGTPFWMAPEVIK-----QSA---YDSKADIWSLGITAIELAR-GE-PP---------------HSEL-----------HPMKVLFLI----PK----NNP----PTLEGNYS-------------------------------KPLKE-FVEACLNKEPSFRPT-----AK-ELLKHKFI---------
----YHVLEMIGEGSFGRVYKGRR---K----------------YSAQ---VVALKFIPKL--G-RSE---KE---L-RNLQR----EIEIMRGL--R---HPNIVHMLDSFE--T----------DKE------VVVVTDYAEG-ELFQILE--------DDG-----------------------------------------------------------------------------------------------------KL---PEDQVQAIAAQLVSALYYLHS--H-----R---ILHRDMKPQNILLA-K-----GG-GI----KLCDFGFARAM---------STNTMVL--------------TS---IKGTPLYMSPELVE-----ERP---YDHTADLWSVGCILYELAV-GT-PP---------------FYAT--------------SIFQLV----SL----ILK----DPVRWPSTIS-----------------------------PCFKN-FLQGLLTKDPRQRLS-----WP-DLLYHPFI---------
----YELQEVIGSGATAVVQAALC---K----------------PRQE---RVAIKRINLE--K-CQT---SM---D-E-LLK----EIQAMSQC--S---HPNVVTYYTSFV--V----------KDE------LWLVMKLLSGGSMLDIIKYIVNRGEHKNG-----------------------------------------------------------------------------------------------------VL---EEAIIATILKEVLEGLDYLHR--N-----G---QIHRDLKAGNILLG-E-----DG-SV----QIADFGVSAFLAT----GGDVTRNKVR--------------KT---FVGTPCWMAPEVME----QVRG---YDFKADMWSFGITAIELAT-GA-AP---------------YHKY-----------PPMKVLMLT----LQ----NDP----PTLETGVEDKE--MMK--------------------KYGKSFRK-LLSLCLQKDPSKRPT-----AA-ELLKCKFF---------
-TLE---DKELGSGNFGTVKKGYY---Q--------------MKKVVK---TVAVKILK-N--E-AN----DPALKD-ELL-A----EANVMQQL--D---NPYIVRMIGICE-------------AES------WMLVMEMAELGPLNKYLQ---------QN----------------------------------------------------------------------------------------------------RHV---KDKNIIELVHQVSMGMKYLEE--S-----N---FVHRDLAARNVLLV-T-----QH-YA----KISDFGLSKAL-----R---A--DENY-------------YKAQTHGKWPVKWYAPECIN-----YYK---FSSKSDVWSFGVLMWEAFSYGQ-KP---------------YRGM-----------KGSEVTAML----EK----GER----MGCPAGCP-------------------------------REMYD-LMNLCWTYDVENRPG-----FA-AVE----LRL-------
----LTFMRELGSGLFGVVRLGKW---R-----------------AQY---KVAIKAIR-E--G-AM----CE---E-DFI-E----EAKVMMKL--T---HPKLVQLYGVCT--Q----------QKP------IYIVTEFMERGCLLNFLR---------QR--------------------------------------------------------------------------------------------------Q-GHF---SRDVLLSMCQDVCEGMEYLER--N-----S---FIHRDLAARNCLVS-E-----AG-VV----KVSDFGMARYV---------L--DDQY--------------TSSSGAKFPVKWCPPEVFN-----YSR---FSSKSDVWSFGVLMWEVFTEGR-MP---------------FEKY-----------TNYEVVTMV----TR----GHR----LYQPKLAS-------------------------------NYVYE-VMLRCWQEKPEGRPS-----FE-DLLRT--I---------
----IEFHEIIGSGSFGKVYKGRC---R------------------NK---IVAIKRYR-ANTY-CS----KSD-VD-MFC-R----EVSILCQL--N---HPCVIQFVGACL-ND----------PSQ------FAIVTQYISGGSLFSLLH---------EQ--------------------------------------------------------------------------------------------------K-RIL---DLQSKLIIAVDVAKGMEYLHNLTQ-----P---IIHRDLNSHNILLY-E-----DG-HA----VVADFGESRFL-----Q---S--LD-E--------------DNMTKQPGNLRWMAPEVFT-----QCT--RYTIKADVFSYALCLWEILT-GE-IP---------------FAHL-----------KPAAAAADM---AYH----HIR----PPIGYSIP-------------------------------KPISS-LLIRGWNACPEGRPE-----FS-EVVMKL-----------
---L-AFIKEIGSGQFGVVHLGEW---R-----------------SHI---QVAIKAIN-E--G-SM----SE---E-DFI-E----EAKVMMKL--S---HSKLVQLYGVCI--Q----------RKP------LYIVTEFMENGCLLNYLR---------EN--------------------------------------------------------------------------------------------------K-GKL---RKEMLLSVCQDICEGMEYLER--N-----G---YIHRDLAARNCLVS-S-----TC-IV----KISDFGMTRYV---------L--DDEY--------------VSSFGAKFPIKWSPPEVFL-----FNK---YSSKSDVWSFGVLMWEVFTEGK-MP---------------FENK-----------SNLQVVEAI----SE----GFR----LYRPHLAP-------------------------------MSIYE-VMYSCWHEKPEGRPT-----FA-ELLR---AV--------
---L-KKIRDLGEGHFGKVSLYCY---DP------------TNDGTGE---MVAVKALK-A--D-CG----PQH-RS-GWK-Q----EIDILRTL--Y---HEHIIKYKGCCEDQG----------EKS------LQLVMEYVPLGSLRDYLP---------RH-----------------------------------------------------------------------------------------------------SI---GLAQLLLFAQQICEGMAYLHA--Q-----H---YIHRDLAARNVLLD-N-----DR-LV----KIGDFGLAKAV----PE---G--HEYY--------------RVREDGDSPVFWYAPECLK-----EYK---FYYASDVWSFGVTLYELLTHCD-SSQSPPTKF-LELIGIAQGQM-----------TVLRLTELL----ER----GER----LPRPDKCP-------------------------------CEVYH-LMKNCWETEASFRPT-----FE-NLIP---IL--------
---F-TLGRMLGKGEFGSVREAQL---K-------------QEDGSFV---KVAVKMLK-A-DI-IA----SSD-IE-EFL-R----EAACMKEF--D---HPHVAKLVGVSL--R----------SRAKGRLPIPMVILPFMKHGDLHAFLL---------ASRI---------------------------------------------------------------------------------------------GENP-FNL---PLQTLIRFMVDIACGMEYLSS--R-----N---FIHRDLAARNCMLA-E-----DM-TV----CVADFGLSRKI-----Y---S--GDYY--------------RQGCASKLPVKWLALESLA-----DNL---YTVQSDVWAFGVTMWEIMTRGQ-TP---------------YAGI-----------ENAEIYNYL----IG----GNR----LKQPPECM-------------------------------EDVYD-LMYQCWSADPKQRPS-----FT-CLRME--L---------
---L-RLEVKLGQGCFGEVWMGTW---N-----------------GTT---KVAIKTLK-P--G-TM----MP---E-AFL-Q----EAQIMKKL--R---HDKLVPLYAVVS-------------EEP------IYIVTEFMSKGSLLDFLK---------EG-------------------------------------------------------------------------------------------------DG-KYL---KLPQLVDMAAQIADGMAYIER--M-----N---YIHRDLRAANILVG-E-----NL-VC----KIADFGLARLI---------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM-----------VNREVLEQV----ER----GYR----MPCPQGCP-------------------------------ESLHE-LMNLCWKKDPDERPT-----FE-YIQSFL-----------
----WTKGEILGKGAYGTVYCGLT---S----------------QGQ----LIAVKQVALD--T-SNK---LA---A-EKEYRKLQEEVDLLKAL--K---HVNIVAYLGTCL--Q----------ENT------VSIFMEFVPGGSISSIIN--------RFG-----------------------------------------------------------------------------------------------------PL---PEMVFCKYTKQILQGVAYLHE--N-----C---VVHRDIKGNNVMLM-P-----TG-II----KLIDFGCARRLAWA---GLNGTHSDML--------------KS---MHGTPYWMAPEVIN-----ESG---YGRKSDIWSIGCTVFEMAT-GK-PP---------------LASM-------------DRMAAMF----YI----GAH----RGLMPPLPDHFS---------------------------ENAAD-FVRMCLTRDQHERPS-----AL-QLLKHSFL---------
LIAD----IELGCGNFGSVRQGVY---R--------------MRKKQI---DVAIKVLK-Q--G-TE----KAD-TE-EMM-R----EAQIMHQL--D---NPYIVRLIGVCQ-------------AEA------LMLVMEMAGGGPLHKFLV---------GK--------------------------------------------------------------------------------------------------R-EEI---PVSNVAELLHQVSMGMKYLEE--K-----N---FVHRDLAARNVLLV-N-----RH-YA----KISDFGLSKAL----GA---D--DSYY--------------TARSAGKWPLKWYAPECIN-----FRK---FSSRSDVWSYGVTMWEALSYGQ-KP---------------YKKM-----------KGPEVMAFI----EQ----GKR----MECPPECP-------------------------------PELYA-LMSDCWIYKWEDRPD-----FL-TVEQR--M---------
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