|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC DYRK1A 203
CMGC CLK1 161
CMGC CLK2 163
CMGC CLK3 156
CMGC CLK4 159
CMGC DYRK1B 111
CMGC DYRK2 222
YEIDSLIGKGSFGQVVKAYDRV-E-QE-WVAIKIIKNKKAFLNQAQI-EVRLLELMNK------HDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLR---NTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAI--------------------KIVDFGSSCQ--LGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF
YEIVDTLGEGAFGKVVECIDHK-AGGR-HVAVKIVKNVDRYCEAARS-EIQVLEHL-NT----TDPNST-FRCVQMLEWFEHHGHICIVFELLGLSTYDFIK--ENGFLP-FRLDHIRKMAYQICKSVNFLHS--NKLTHTDLKPENILFV--QSDYTEAYNPKIKR-DERTLINPDIKVVDFGSA--TYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRY--------------------VSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF
YEIVSTLGEGTFGRVVQCVDHR-R-GGARVALKIIKNVEKYKEAAR-LEINVLEKI-NEK-DPDNKN----LCVQMFDWFDYHGHMCISFELLGLSTFDFLK--DNNYLP-YPIHQVRHMAFQLCQAVKFLHD--NKLTHTDLKPENILFV--NSDYELTYNLEKKR-DERSVKSTAVRVVDFGSAT--FDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY--------------------VRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF
YEIVGNLGEGTFGKVVECLDHA-R-GKSQVALKIIRNVGKYREAAR-LEINVLKKI-KE---KDKENK--FLCVLMSDWFNFHGHMCIAFELLGKNTFEFLK---ENNFQPYPLPHVRHMAYQLCHALRFLHE--NQLTHTDLKPENILFV--NSE-FETLYNEHKSCEEKSVKNTSIRVADFGSAT--FDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRY--------------------VKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF
YEIVDTLGEGAFGKVVECIDHGMD-GM-HVAVKIVKNVGRYREAARS-EIQVLEHL-NS----TDPNSV-FRCVQMLEWFDHHGHVCIVFELLGLSTYDFIK--ENSFLP-FQIDHIRQMAYQICQSINFLHH--NKLTHTDLKPENILFV--KSDYVVKYNSKMKR-DERTLKNTDIKVVDFGSA--TYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRY--------------------VRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF
YEIDSLIGKGSFGQVVKAYDHQ-T-QE-LVAIKIIKNKKAFLNQAQI-ELRLLELMNQ------HDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLR---NTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAI--------------------KIVDFGSSCQ--LGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF
YEVLKVIGKGSFGQVVKAYDHK-V-HQ-HVALKMVRNEKRFHRQAAE-EIRILEHL-RKQDKDNTMN-----VIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGF---SLPLVRKFAHSILQCLDALHK--NRIIHCDLKPENILLK--QQGRSG------------------IKVIDFGSSC--YEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNG-----GRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL
|