|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC DYRK1A 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
CMGC DYRK2 222
CMGC DYRK3 209
CMGC MAPK14 24
AGC PDPK1 82
-YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQ-I---EVRLLELMNK------HDTEMKYYIVHLKRHFMF------RNHLCLVFEMLSY-NLYDLLR----NTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAI--KIVDFGSSCQ-----LGQRIYQYIQSRFYRSPEVLL-GMPYDLAIDMWSLGCILVEMHT-GEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF-----------
-YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPS-TAIREISLLKEL-R------HPN-----IVSLQDVLMQ------DSRLYLIFEFLSM-DLKKYLDSIPPGQYM---DSSLVKSYLYQILQGIVFCHS--RRVLHRDLKPQNLLID--DKGTI--KLADFGLARAF--GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF-----------
-FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPS-TAIREISLLKEL-N------HPN-----IVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDA-SALTGI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN--TEGAI--KLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-----------
-YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPS-SALREICLLKEL-K------HKN-----IVRLHDVLHS------DKKLTLVFEFCDQ-DLKKYFD--SCNGDL---DPEIVKSFLFQLLKGLGFCHS--RNVLHRDLKPQNLLIN--RNGEL--KLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-----------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF-----------
-YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAA-E---EIRILEHL-RKQDKDNTMN-----VIHMLENFTF------RNHICMTFELLSM-NLYELIKK-NKFQGF---SLPLVRKFAHSILQCLDALHK--NRIIHCDLKPENILLK--QQGRSGIKVIDFGSSC-----YEHQRVYTYIQSRFYRAPEVIL-GARYGMPIDMWSLGCILAELLT-GYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNG-----GRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL-----------
-YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA-E---EIRILEHL-KKQDKTGSMN-----VIHMLESFTF------RNHVCMAFELLSI-DLYELIKK-NKFQGF---SVQLVRKFAQSILQSLDALHK--NKIIHCDLKPENILLK--HHGRSSTKVIDFGSSCF-----EYQKLYTYIQSRFYRAPEIIL-GSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVG-----GRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI-----------
-YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK-RTYRELRLLKHM-K------HEN-----VIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK----CQKL---TDDHVQFLIYQILRGLKYIHS--ADIIHRDLKPSNLAVN--EDCEL--KILDFGLAR-----HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP---------------------------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-----------
F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-D------HPF-----FVKLYFTFQD------DEKLYFGLSYAKNGELLKYIR---KIGSF---DETCTRFYTAEIVSALEYLHG--KGIIHRDLKPENILLN--EDMHI--QITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIFQKIIKLEYDFPEKFF-------------------------------------------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
|