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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EGFR 203
TK ABL1 261
TK ALK 1116
Other AURKA 133
TKL BRAF 456
TK ERBB2 720
TK FGFR1 478
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK ITK 363
TK JAK2 849
TK JAK3 822
TK KIT 589
TK LCK 245
TK LYN 247
TK NTRK1 510
TK PDGFRA 593
TK PDGFRB 600
AGC PDPK1 82
TK RET 724
STE SLK 34
TK SRC 270
TK SYK 371
TK TNK2 150
TK TXK 271
--F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E--A-TS-PKA-NKE-IL-DEAYVMASV-DNPHVCRLLGICL---TSTVQLITQLMPFGCLLDYVR--EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL--G-A--EEKE-YHAEGGKVPIKWMALESIL-----HRI---YTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSIL-EKGER----LPQPPICT--IDVYMIMVKCWMIDADSRPKFRELI----IEF---------
---ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E--D-TM-EV---EE-FL-KEAAVMKEI-KHPNLVQLLGVCT--REPPFYIITEFMTYGNLLDYLR--EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKVADFGLSRLM----T--GDTY-TAHAGAKFPIKWTAPESLA-----YNK---FSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELL-EKDYR----MERPEGCP--EKVYELMRACWQWNPSDRPSFAEIHQA--F-----------
--I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-E--V-CS-EQD-ELD-FL-MEALIISKF-NHQNIVRCIGVSL--QSLPRFILLELMAGGDLKSFLR--ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI--Y-R--ASYY-RKGGCAMLPVKWMPPEAFM-----EGI---FTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK-SNQEVLEFV-TSGGR----MDPPKNCP--GPVYRIMTQCWQHQPEDRPNFAIILER--I-----------
---FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA--QLEKAGV---EH-QLRREVEIQSHL-RHPNILRLYGYFH--DATRVYLILEYAPLGTVYRELQ-KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS---AGELKIADFGWSV------HAPSSRR-TT---LCGTLDYLPPEMIE-----GRM---HDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETY-KRISR----VEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI-----------
---ITVGQRIGSGSFGTVYKGKWH----------GDVAVKMLN-V-TA-PT-PQQ-LQA-FK-NEVGVLRKT-RHVNILLFMGYST---KPQLAIVTQWCEGSSLYHHLH--II--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHE---DLTVKIGDFGLATVK--S-R--WSGS-HQFEQLSGSILWMAPEVIR-----MQDKNPYSFQSDVYAFGIVLYELMT-GQLP---------------YSNINNRDQIIFMV-GRGYLSPDLSKVRSNCP--KAMKRLMAECLKKKRDERPLFPQILA---SI----------
--L-RKVKVLGSGAFGTVYKGIWIP---DGENVKIPVAIKVLR-E--N-TS-PKA-NKE-IL-DEAYVMAGV-GSPYVSRLLGICL---TSTVQLVTQLMPYGCLLDHVR--EN--------------------------------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKS---PNHVKITDFGLARLL--D-I--DETE-YHADGGKVPIKWMALESIL-----RRR---FTHQSDVWSYGVTVWELMTFGAKP---------------YDGI-PAREIPDLL-EKGER----LPQPPICT--IDVYMIMVKCWMIDSECRPRFRELVSE--F-----------
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--D-AT-EKD-LSD-LI-SEMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLQ--ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI--H-H--IDYY-KKTTNGRLPVKWMAPEALF-----DRI---YTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-PVEELFKLL-KEGHR----MDKPSNCT--NELYMMMRDCWHAVPSQRPTFKQLVEDL-------------
---LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-P--G-SM-SV---EA-FL-AEANVMKTL-QHDKLVKLHAVVT---KEPIYIITEFMAKGSLLDFLK--SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA---SLVCKIADFGLARVI----E--DNEY-TAREGAKFPIKWTAPEAIN-----FGS---FTIKSDVWSFGILLMEIVTYGRIP---------------YPGM-SNPEVIRAL-ERGYR----MPRPENCP--EELYNIMMRCWKNRPEERPTFEYIQSV--L-----------
---ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-E--A-AS-MRE-RIE-FL-NEASVMKEF-NCHHVVRLLGVVS--QGQPTLVIMELMTRGDLKSYLR--SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI--Y-E--TDYY-RKGGKGLLPVRWMSPESLK-----DGV---FTTYSDVWSFGVVLWEIATLAEQP---------------YQGL-SNEQVLRFV-MEGGL----LDKPDNCP--DMLFELMRMCWQYNPKMRPSFLEIISS--I-----------
---ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-E--S-AS-LRE-RIE-FL-NEASVMKGF-TCHHVVRLLGVVS--KGQPTLVVMELMAHGDLKSYLR--SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI--Y-E--TDYY-RKGGKGLLPVRWMAPESLK-----DGV---FTTSSDMWSFGVVLWEITSLAEQP---------------YQGL-SNEQVLKFV-MDGGY----LDQPDNCP--ERVTDLMRMCWQFNPKMRPTFLEIVNLL-------------
---LTFVQEIGSGQFGLVHLGYWL--------NKDKVAIKTIR-E--G-AM-SE---ED-FI-EEAEVMMKL-SHPKLVQLYGVCL--EQAPICLVFEFMEHGCLSDYLR--TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGE---NQVIKVSDFGMTRFV----L--DDQY-TSSTGTKFPVKWASPEVFS-----FSR---YSSKSDVWSFGVLMWEVFSEGKIP---------------YENR-SNSEVVEDI-STGFR----LYKPRLAS--THVYQIMNHCWKERPEDRPAFSRLLRQL-------------
---LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-H--S-TE--EH-LRD-FE-REIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ--KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN---ENRVKIGDFGLTKVL-PQ-D--KEYY-KVKEPGESPIFWYAPESLT-----ESK---FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELL-KNNGR----LPRPDGCP--DEIYMIMTECWNNNVNQRPSFRDLA----LRV---------
--L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAVKQLQ-H--S-GP-DQ--QRD-FQ-REIQILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ--RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVES---EAHVKIADFGLAKLL-PL-D--KDYY-VVREPGQSPIFWYAPESLS-----DNI---FSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELL-EEGQR----LPAPPACP--AEVHELMKLCWAPSPQDRPSFSALGP---QL----------
---LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKMLK-P--S-AH-LTE-REA-LM-SELKVLSYLGNHMNIVNLLGACT--IGGPTLVITEYCCYGDLLNFLR--RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH---GRITKICDFGLARDI--K-N--DSNY-VVKGNARLPVKWMAPESIF-----NCV---YTFESDVWSYGIFLWELFSLGSSP---------------YPGMPVDSKFYKMI-KEGFR----MLSPEHAP--AEMYDIMKTCWDADPLKRPTFKQIVQL--I-----------
---LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q--G-SM-SP---DA-FL-AEANLMKQL-QHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLK--TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI----E--DNEY-TAREGAKFPIKWTAPEAIN-----YGT---FTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNL-ERGYR----MVRPDNCP--EELYQLMRLCWKERPEDRPTFDYLRSV--L-----------
---IKLVKRLGAGQFGEVWMGYYN--------NSTKVAVKTLK-P--G-TM-SV---QA-FL-EEANLMKTL-QHDKLVRLYAVVT--REEPIYIITEYMAKGSLLDFLK--SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSE---SLMCKIADFGLARVI----E--DNEY-TAREGAKFPIKWTAPEAIN-----FGC---FTIKSDVWSFGILLYEIVTYGKIP---------------YPGR-TNADVMTAL-SQGYR----MPRVENCP--DELYDIMKMCWKEKAEERPTFDYLQSV--L-----------
-IV--LKWELGEGAFGKVFLAECHN--LLPEQDKMLVAVKALK-E--A-SE-SA--RQD-FQ-REAELLTML-QHQHIVRFFGVCT--EGRPLLMVFEYMRHGDLNRFLR--SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ---GLVVKIGDFGMSRDI--Y-S--TDYY-RVGGRTMLPIRWMPPESIL-----YRK---FTTESDVWSFGVVLWEIFTYGKQP---------------WYQL-SNTEAIDCI-TQGRE----LERPRACP--PEVYAIMRGCWQREPQQRHSIKDVHARL-------------
--L-VLGRVLGSGAFGKVVEGTAYG--LSRSQPVMKVAVKMLK-P--T-AR-SSE-KQA-LM-SELKIMTHLGPHLNIVNLLGACT--KSGPIYIITEYCFYGDLVNYLH--KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQ---GKIVKICDFGLARDI--M-H--DSNY-VSKGSTFLPVKWMAPESIF-----DNL---YTTLSDVWSYGILLWEIFSLGGTP---------------YPGMMVDSTFYNKI-KSGYR----MAKPDHAT--SEVYEIMVKCWNSEPEKRPSFYHLSE---IV----------
--L-VLGRTLGSGAFGQVVEATAHG--LSHSQATMKVAVKMLK-S--T-AR-SSE-KQA-LM-SELKIMSHLGPHLNVVNLLGACT--KGGPIYIITEYCRYGDLVDYLH--RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICE---GKLVKICDFGLARDI--M-R--DSNY-ISKGSTFLPLKWMAPESIF-----NSL---YTTLSDVWSFGILLWEIFTLGGTP---------------YPELPMNEQFYNAI-KRGYR----MAQPAHAS--DEIYEIMQKCWEEKFEIRPPFSQLVL---LL----------
--F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKILEKR--H-IIKEN---KVPYVTRERDVMSRL-DHPFFVKLYFTFQ--DDEKLYFGLSYAKNGELLKYIR-KIG----------------------------------------------------------------------------------------------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNE---DMHIQITDFGTAKVLS--PESKQARA-NS---FVGTAQYVSPELLT-----EKS---ACKSSDLWALGCIIYQLVA-GLPP---------------FRAG----NEYLIF-QKIIK----LEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
--L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E--N-AS-PSE-LRD-LL-SEFNVLKQV-NHPHVIKLYGACS--QDGPLLLIVEYAKYGSLRGFLR--ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV--Y-E--EDSY-VKRSQGRIPVKWMAIESLF-----DHI---YTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-PPERLFNLL-KTGHR----MERPDNCS--EEMYRLMLQCWKQEPDKRPVFADISKDL-------------
---WEIIGELGDGAFGKVYKAQNK-------ETSVLAAAKVIDTK--S-EEELE---DY-M--VEIDILASC-DHPNIVKLLDAFY--YENNLWILIEFCAGGAVDAVMLELER----------------------------------------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTL---DGDIKLADFGVSAKN----TRTIQRR-DS---FIGTPYWMAPEVVMCETSKDRP---YDYKADVWSLGITLIEMAE-IEPP---------------HHEL-NPMRVLLKI-AKSEP----PTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV-----------
--L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P--G-TM-SP---EA-FL-QEAQVMKKL-RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLK--GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI----E--DNEY-TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQV-ERGYR----MPCPPECP--ESLHDLMCQCWRKEPEERPTFEYLQAF--L-----------
TLE---DKELGSGNFGTVKKGYYQ-----MKKVVKTVAVKILK-N--E-AN-DPALKDE-LL-AEANVMQQL-DNPYIVRMIGICE---AESWMLVMEMAELGPLNKYLQ--QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT---QHYAKISDFGLSKAL--R-A--DENYYKAQTHGKWPVKWYAPECIN-----YYK---FSSKSDVWSFGVLMWEAFSYGQKP---------------YRGM-KGSEVTAML-EKGER----MGCPAGCP--REMYDLMNLCWTYDVENRPGFAAVE----LRL---------
--L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVL-SQ-PEA-MDD-FI-REVNAMHSL-DHRNLIRLYGVVL---TPPMKMVTELAPLGSLLDRLR--KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLAT---RDLVKIGDFGLMRAL-PQ-N--DDHY-VMQEHRKVPFAWCAPESLK-----TRT---FSHASDTWMFGVTLWEMFTYGQEP---------------WIGL-NGSQILHKIDKEGER----LPRPEDCP--QDIYNVMVQCWAHKPEDRPTFVALRDF--L-----------
--L-AFIKEIGSGQFGVVHLGEWR--------SHIQVAIKAIN-E--G-SM-SE---ED-FI-EEAKVMMKL-SHSKLVQLYGVCI--QRKPLYIVTEFMENGCLLNYLR--EN--------------------------------------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSS---TCIVKISDFGMTRYV----L--DDEY-VSSFGAKFPIKWSPPEVFL-----FNK---YSSKSDVWSFGVLMWEVFTEGKMP---------------FENK-SNLQVVEAI-SEGFR----LYRPHLAP--MSIYEVMYSCWHEKPEGRPTFAELLR---AV----------
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