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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EPHB4 203
TK ALK 1116
TKL BRAF 456
TK EGFR 712
TK FGFR1 478
TK FYN 271
TK IGF1R 999
TK INSR 1023
TK JAK1 875
TK JAK2 849
TK KDR 834
TK SRC 270
V-KIEEVIGAGEFGEVCRGRLK----APGKKESCVAIKTLKG-GYTERQRREFLSEASIMGQF-EHPNIIRLEGVVT--NSMP--VMILTEFMENGALDSFLRLN-----------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNS---NLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRK---FTSASDAWSYGIVMWEVMSFGERP---------------YWDM-SNQDVINAIEQDYR----LPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSAL---
I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLPE-VCSEQDELDFLMEALIISKF-NHQNIVRCIGVSL--QSLP--RFILLELMAGGDLKSFLRETRP-----------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI---YRASYYRKGGCAMLPVKWMPPEAFMEGI---FTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK-SNQEVLEFVTSGGR----MDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILER-I--
-ITVGQRIGSGSFGTVYKGKWH----------GDVAVKMLNVTAPTPQQLQAFKNEVGVLRKT-RHVNILLFMGYST---KPQ--LAIVTQWCEGSSLYHHLHII-----------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHE---DLTVKIGDFGLATVK---SRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLP---------------YSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA--SI-
F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELRE-ATSPKANKEILDEAYVMASV-DNPHVCRLLGICL---TST--VQLITQLMPFGCLLDYVREH-----------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL---GAEEKEYHAEGGKVPIKWMALESILHRI---YTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSILEKGER----LPQPPICTIDVYMIMVKCWMIDADSRPKFRELI---IEF
L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKS-DATEKDLSDLISEMEMMKMIGKHKNIINLLGACT--QDGP--LYVIVEYASKGNLREYLQARRPPGLEY--------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI---HHIDYYKKTTNGRLPVKWMAPEALFDRI---YTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-PVEELFKLLKEGHR----MDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL---
-LQLIKRLGNGQFGEVWMGTWN--------GNTKVAIKTLKP-GTMSP--ESFLEEAQIMKKL-KHDKLVQLYAVVS---EEP--IYIVTEYMNKGSLLDFLKDG----------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGN---GLICKIADFGLARLI----EDNEYTARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILLTELVTKGRVP---------------YPGM-NNREVLEQVERGYR----MPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFL---
-ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVNE-AASMRERIEFLNEASVMKEF-NCHHVVRLLGVVS--QGQP--TLVIMELMTRGDLKSYLRSLRPEM--------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI---YETDYYRKGGKGLLPVRWMSPESLKDGV---FTTYSDVWSFGVVLWEIATLAEQP---------------YQGL-SNEQVLRFVMEGGL----LDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISS-I--
-ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVNE-SASLRERIEFLNEASVMKGF-TCHHVVRLLGVVS--KGQP--TLVVMELMAHGDLKSYLRSLRPEA--------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI---YETDYYRKGGKGLLPVRWMAPESLKDGV---FTTSSDMWSFGVVLWEITSLAEQP---------------YQGL-SNEQVLKFVMDGGY----LDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL---
L-KRIRDLGEGHFGKVELCRYDP---EGDNTGEQVAVKSLKP-ESGGNHIADLKKEIEILRNL-YHENIVKYKGICT-ED-GGNGIKLIMEFLPSGSLKEYLPKN-----------------------------------------------------------------KNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVES---EHQVKIGDFGLTKAI--ETDKEYYTVKDDRDSPVFWYAPECLMQSK---FYIASDVWSFGVTLHELLTYCDSDSSPMALF-LKMIGPTHGQM-TVTRLVNTLKEGKR----LPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIE--GF-
-LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQH-STE-EHLRDFEREIEILKSL-QHDNIVKYKGVCYSAGRRN--LKLIMEYLPYGSLRDYLQKH-----------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN---ENRVKIGDFGLTKVL--PQDKEYYKVKEPGESPIFWYAPESLTESK---FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGR----LPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLA---LRV
-LKLGKPLGRGAFGQVIEADAFG--IDKTATCRTVAVKMLKE-GATHSEHRALMSELKILIHIGHHLNVVNLLGACT-KPGGP--LMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE---KNVVKICDFGLARDI---YKDPDYVRKGDARLPLKWMAPETIFDRV---YTIQSDVWSFGVLLWEIFSLGASP---------------YPGVKIDEEFCRRLKEGTR----MRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL---
L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLKP-GTMSP--EAFLQEAQVMKKL-RHEKLVQLYAVVS---EEP--IYIVTEYMSKGSLLDFLKGE----------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI----EDNEYTARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYR----MPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF-L--
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