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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK ERBB3 203
TK ABL1 261
TK ALK 1116
TK EGFR 712
TK EPHA3 621
TK FGFR1 478
TK FGFR2 481
TK HCK 241
TK IGF1R 999
TK INSR 1023
TKL IRAK4 186
TK KIT 589
TK LCK 245
TK MERTK 587
STE OXSR1 17
TK PTK2B 425
TK RET 724
TK SRC 270
STE STK24 24
TK TNK2 150
TK ZAP70 338
---L-RKLKVLGSGVFGTVHKGVWIP---EGESIKIPVCIKVIE-D--KSG-RQSFQ-AVT-D-HMLAIGSL-DHAHIVRLLGLCP-GSS-----LQLVTQYLPLGSLLDHVR---------QH---------------------------------------------------------------------------RGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKS---PSQVQVADFGVADLL---P---P--DDKQ-LLYSEAKTPIKWMALESIH-FGKYTHQSDVWSYGVTVWELMTFGAEPYAGL-RLAEVPDLL-EKGERLAQPQICT--------------IDVYMVMVKCWMIDENIRPTFKELANE--F---
----ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E--DTM-EV--E-EFL-K-EAAVMKEI-KHPNLVQLLGVCTREPP-----FYIITEFMTYGNLLDYLR---------EC--------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKVADFGLSRLM-------T--GDTY-TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELL-EKDYRMERPEGCP--------------EKVYELMRACWQWNPSDRPSFAEIHQA--F---
---I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-E--VCS-EQDEL-DFL-M-EALIISKF-NHQNIVRCIGVSLQSLP-----RFILLELMAGGDLKSFLR---------ETRP---------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI---Y---R--ASYY-RKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSK-SNQEVLEFV-TSGGRMDPPKNCP--------------GPVYRIMTQCWQHQPEDRPNFAIILER--I---
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E--ATS-PKANK-EIL-D-EAYVMASV-DNPHVCRLLGICL-TST-----VQLITQLMPFGCLLDYVR---------EH---------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL---G---A--EEKE-YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSIL-EKGERLPQPPICT--------------IDVYMIMVKCWMIDADSRPKFRELI----IEF-
---I-SIDKVVGAGEFGEVCSGRLK----LPSKKEISVAIKTLK-V--GYT-EKQRR-DFL-G-EASIMGQF-DHPNIIRLEGVVTKSKP-----VMIVTEYMENGSLDSFLR---------KH---------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINS---NLVCKVSDFGLSRVL---E---D--DPEAAYTTRGGKIPIRWTSPEAIA-YRKFTSASDVWSYGIVLWEVMSYGERPYWEM-SNQDVIKAV-DEGYRLPPPMDCP--------------AALYQLMLDCWQKDRNNRPKFEQIVSIL-----
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--DAT-EKDLS-DLI-S-EMEMMKMIGKHKNIINLLGACTQDGP-----LYVIVEYASKGNLREYLQ---------ARRPPGLEY------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI---H---H--IDYY-KKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLL-KEGHRMDKPSNCT--------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-----
----LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-D--DAT-EKDLS-DLV-S-EMEMMKMIGKHKNIINLLGACTQDGP-----LYVIVEYASKGNLREYLR---------ARRPPGMEY------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDI---N---N--IDYY-KKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLL-KEGHRMDKPANCT--------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-----
----LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-P--GSM-SV--E-AFL-A-EANVMKTL-QHDKLVKLHAVVT-KEP-----IYIITEFMAKGSLLDFLK---------SD--------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA---SLVCKIADFGLARVI-------E--DNEY-TAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIPYPGM-SNPEVIRAL-ERGYRMPRPENCP--------------EELYNIMMRCWKNRPEERPTFEYIQSV--L---
----ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-E--AAS-MRERI-EFL-N-EASVMKEF-NCHHVVRLLGVVSQGQP-----TLVIMELMTRGDLKSYLR---------SLRPEM------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI---Y---E--TDYY-RKGGKGLLPVRWMSPESLK-DGVFTTYSDVWSFGVVLWEIATLAEQPYQGL-SNEQVLRFV-MEGGLLDKPDNCP--------------DMLFELMRMCWQYNPKMRPSFLEIISS--I---
----ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-E--SAS-LRERI-EFL-N-EASVMKGF-TCHHVVRLLGVVSKGQP-----TLVVMELMAHGDLKSYLR---------SLRPEA------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI---Y---E--TDYY-RKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQPYQGL-SNEQVLKFV-MDGGYLDQPDNCP--------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL-----
-VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKLAAM--VDITTE--ELKQQFDQEIKVMAKC-QHENLVELLGFSSDGDD-----LCLVYVYMPNGSLLDRLSC-----LDGTP-----------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDE---AFTAKISDFGLARASE-----KFAQTVMT-SR---IVGTTAYMAPEALR--GEITPKSDIYSFGVVLLEIIT-GLPAVDEH-REPQLLLDI-KEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ
----LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKMLK-P--SAH-LTERE-ALM-S-ELKVLSYLGNHMNIVNLLGACTIGGP-----TLVITEYCCYGDLLNFLR---------RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH---GRITKICDFGLARDI---K---N--DSNY-VVKGNARLPVKWMAPESIF-NCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMI-KEGFRMLSPEHAP--------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I---
----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q--GSM-SP--D-AFL-A-EANLMKQL-QHQRLVRLYAVVT-QEP-----IYIITEYMENGSLVDFLK---------TP--------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI-------E--DNEY-TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNL-ERGYRMVRPDNCP--------------EELYQLMRLCWKERPEDRPTFDYLRSV--L---
---L-ILGKILGEGEFGSVMEGNLK----QEDGTSLKVAVKTMKLD--NSS-QREIE-EFL-S-EAACMKDF-SHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLL---------YSRL----------------------------------------------------------------------ETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRD---DMTVCVADFGLSKKI---Y---S--GDYY-RQGRIAKMPVKWIAIESLA-DRVYTSKSDVWAFGVTMWEIATRGMTPYPGV-QNHEMYDYL-LHGHRLKQPEDCL--------------DELYEIMYSCWRTDPLDRPTFSVLRLQ--L---
----YELQEVIGSGATAVVQAAYCA-------PKKEKVAIKRINLE--KCQTSM--D-E-LLK-EIQAMSQC-HHPNIVSYYTSFVVKDE-----LWLVMKLLSGGSVLDIIKHIVAKGEHKSG-----------------------------------------------------------------------------VLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGE---DGSVQIADFGVSAFLAT--GGDITRNKVR-KT---FVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELAT-GAAPYHKY-PPMKVLMLT-LQNDPPSLETGVQDKE--MLK---KYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF---
---V-VLNRILGEGFFGEVYEGVYT----NHKGEKINVAVKTCK-K--DCT-LDNKE-KFM-S-EAVIMKNL-DHPHIVKLIGIIE-EEP-----TWIIMELYPYGELGHYLE---------RN---------------------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVAS---PECVKLGDFGLSRYI-------E--DEDY-YKASVTRLPIKWMSPESIN-FRRFTTASDVWMFAVCMWEILSFGKQPFFWL-ENKDVIGVL-EKGDRLPKPDLCP--------------PVLYTLMTRCWDYDPSDRPRFTELVCS--L---
---L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E--NAS-PSELR-DLL-S-EFNVLKQV-NHPHVIKLYGACSQDGP-----LLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSG----------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV---Y---E--EDSY-VKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLL-KTGHRMERPDNCS--------------EEMYRLMLQCWKQEPDKRPVFADISKDL-----
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P--GTM-SP--E-AFL-Q-EAQVMKKL-RHEKLVQLYAVVS-EEP-----IYIVTEYMSKGSLLDFLK---------GE--------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI-------E--DNEY-TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQV-ERGYRMPCPPECP--------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L---
----FTKLEKIGKGSFGEVFKGIDN-------RTQKVVAIKIIDLE--EAEDEI--E-DIQ-Q-EITVLSQC-DSPYVTKYYGSYLKDTK-----LWIIMEYLGGGSALDLLE---------PG-----------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSE---HGEVKLADFGVAGQL-------TDTQIKR-NT---FVGTPFWMAPEVIK-QSAYDSKADIWSLGITAIELAR-GEPPHSEL-HPMKVLFLI-PKNNPPTLEGNYS--------------KPLKEFVEACLNKEPSFRPTAKELLKHKFI---
---L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVLSQ-PEAMD-DFI-R-EVNAMHSL-DHRNLIRLYGVVL-TPP-----MKMVTELAPLGSLLDRLR---------KH---------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLAT---RDLVKIGDFGLMRAL--PQ---N--DDHY-VMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGL-NGSQILHKIDKEGERLPRPEDCP--------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L---
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-Q--GTE-KADTE-EMM-R-EAQIMHQL-DNPYIVRLIGVCQ-AEA-----LMLVMEMAGGGPLHKFLV---------GK---------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKAL--GA---D--DSYY-TARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKPYKKM-KGPEVMAFI-EQGKRMECPPECP--------------PELYALMSDCWIYKWEDRPDFLTVEQR--M---
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