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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FGFR1 203
TK ABL1 261
Other AURKA 133
Other AURKB 77
CMGC CDC2 4
CMGC CDK2 4
TK CSF1R 582
TK EGFR 712
TK IGF1R 999
TK JAK2 849
TK KDR 834
TK KIT 589
TK LCK 245
CMGC MAPK14 24
CAMK NUAK1 55
TK PDGFRB 600
TK PTK2 422
TK PTK6 191
TK ROS1 1945
TK SRC 270
TK SYK 371
TK TEK 824
TK YES1 277
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SD-AT-EKD-LSDLI-S-EMEMMKMIGKHKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE-----DNVMKIADFGLARDI-HH--IDYY-KKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-PVEELFKLLKEGHRMDKPSNCT------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL----
---ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-ED-TM-EV---EEFL-K-EAAVMKEI-KHPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR----EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE-----NHLVKVADFGLSRLM--T--GDTY-TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELLEKDYRMERPEGCP------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F--
---FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKAGV---EHQLRR-EVEIQSHL-RHPNILRLYGYFH--D------ATRVYLILEYAPLGTVYRELQ---KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS-----AGELKIADFGWSV----HAPSSRR-TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETYKRISRVEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
---FEIGRPLGKGKFGNVYLAREK-------KSHFIVALKVLFKSQ-IEKEG---VEHQLRREIEIQAHL-HHPNILRLYNYFY--D------RRRIYLILEYAPRGELYKELQ---KSC----------------------------------------------------------------------------------------------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGL-----KGELKIADFGWSV----HAPSLRR-KT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA----SHNETYRRIVKVDLKFPASVP----------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV--
---YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLES-EEEGV---PSTAIR-EISLLKEL-RHPNIVSLQDVLM--Q------DSRLYLIFEFLSM-DLKKYLDSIPPGQ----------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDD-----KGTIKLADFGLARAF--GIPIRVY-TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
---FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDT-ETEGV---PSTAIR-EISLLKEL-NHPNIVKLLDVIH--T------ENKLYLVFEFLHQ-DLKKFMDA-SALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT-----EGAIKLADFGLARAF--GVPVRTY-TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
---LQFGKTLGAGAFGKVVEATAFG--LGKEDAVLKVAVKMLK-ST-AH-ADE-KEALM-S-ELKIMSHLGQHENIVNLLGACT--H------GGPVLVITEYCCYGDLLNFLR----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN-----GHVAKIGDFGLARDI-MN--DSNY-IVKGNARLPVKWMAPESIF-DCVYTVQSDVWSYGILLWEIFSLGLNP---------------YPGILVNSKFYKLVKDGYQMAQPAFAP------------------------------KNIYSIMQACWALEPTHRPTFQQICSFL----
--F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-EA-TS-PKA-NKEIL-D-EAYVMASV-DNPHVCRLLGICL---------TSTVQLITQLMPFGCLLDYVR----EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT-----PQHVKITDFGLAKLL-GA--EEKE-YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSILEKGERLPQPPICT------------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF
---ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-EA-AS-MRE-RIEFL-N-EASVMKEF-NCHHVVRLLGVVS--Q------GQPTLVIMELMTRGDLKSYLR----SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE-----DFTVKIGDFGMTRDI-YE--TDYY-RKGGKGLLPVRWMSPESLK-DGVFTTYSDVWSFGVVLWEIATLAEQP---------------YQGL-SNEQVLRFVMEGGLLDKPDNCP------------------------------DMLFELMRMCWQYNPKMRPSFLEIISS--I--
---LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-HS-TE--EH-LRDFE-R-EIEILKSL-QHDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ----KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN-----ENRVKIGDFGLTKVLPQD--KEYY-KVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
---LKLGKPLGRGAFGQVIEADAFG--IDKTATCRTVAVKMLK-EG-AT-HSE-HRALM-S-ELKILIHIGHHLNVVNLLGACT-KP------GGPLMVIVEFCKFGNLSTYLR----SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE-----KNVVKICDFGLARDI-YK--DPDY-VRKGDARLPLKWMAPETIF-DRVYTIQSDVWSFGVLLWEIFSLGASP---------------YPGVKIDEEFCRRLKEGTRMRAPDYTT------------------------------PEMYQTMLDCWHGEPSQRPTFSELVEHL----
---LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKMLK-PS-AH-LTE-REALM-S-ELKVLSYLGNHMNIVNLLGACT--I------GGPTLVITEYCCYGDLLNFLR----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH-----GRITKICDFGLARDI-KN--DSNY-VVKGNARLPVKWMAPESIF-NCVYTFESDVWSYGIFLWELFSLGSSP---------------YPGMPVDSKFYKMIKEGFRMLSPEHAP------------------------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I--
---LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QG-SM-SP---DAFL-A-EANLMKQL-QHQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK----TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD-----TLSCKIADFGLARLI--E--DNEY-TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--
---YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRPF-QSIIH---AKRTYR-ELRLLKHM-KHENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK----CQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE-----DCELKILDFGLAR-----HTDDEM-TG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FPGT-DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF--
---YELQETLGKGTYGKVKRATER-------FSGRVVAIKSIRKDK-IKDEQ---DMVHIRREIEIMSSL-NHPHIISIYEVFE--N------KDKIVIIMEYASKGELYDYIS---ERR----------------------------------------------------------------------------------------------------RLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDD-----NCNIKIADFGLSNL---YQKDKFL-QT---FCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVY-GTMP---------------FDGF----DHKNLIRQISSGEYREPTQP-----------------------------SDARGLIRWMLMVNPDRRATIEDIANHWW-V-
--L-VLGRTLGSGAFGQVVEATAHG--LSHSQATMKVAVKMLK-ST-AR-SSE-KQALM-S-ELKIMSHLGPHLNVVNLLGACT--K------GGPIYIITEYCRYGDLVDYLH----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICE-----GKLVKICDFGLARDI-MR--DSNY-ISKGSTFLPLKWMAPESIF-NSLYTTLSDVWSFGILLWEIFTLGGTP---------------YPELPMNEQFYNAIKRGYRMAQPAHAS------------------------------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL-
---IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-NC-TS-DSV-REKFL-Q-EALTMRQF-DHPHIVKLIGVIT---------ENPVWIIMELCTLGELRSFLQ----VR--------------------------------------------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSS-----NDCVKLGDFGLSRYM--E--DSTY-YKASKGKLPIKWMAPESIN-FRRFTSASDVWMFGVCMWEILMHGVKP---------------FQGV-KNNDVIGRIENGERLPMPPNCP------------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL----
--F-TLCRKLGSGYFGEVFEGLWK--------DRVQVAIKVIS-RD-NL-LH--QQMLQ-S-EIQAMKKL-RHKHILALYAVVS--V------GDPVYIITELMAKGSLLELLR----DS-------------------------------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGE-----NTLCKVGDFGLARLI-----KEDV-YLSHDHNIPYKWTAPEALS-RGHYSTKSDVWSFGILLHEMFSRGQVP---------------YPGM-SNHEAFLRVDAGYRMPCPLECP------------------------------PSVHKLMLTCWCRDPEQRPCFKALRERL----
-LT--LRLLLGSGAFGEVYEGTAVDI-LGVGSGEIKVAVKTLK-KG-ST-DQE-KIEFL-K-EAHLMSKF-NHPNILKQLGVCL--L------NEPQYIILELMEGGDLLTYLR----KARM--------------------------------------------------------------------------------------------ATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI-YK--NDYY-RKRGEGLLPVRWMAPESLM-DGIFTTQSDVWSFGILIWEILTLGHQP---------------YPAH-SNLDVLNYVQTGGRLEPPRNCP------------------------------DDLWNLMTQCWAQEPDQRPTFHRIQDQL----
--L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PG-TM-SP---EAFL-Q-EAQVMKKL-RHEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK----GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE-----NLVCKVADFGLARLI--E--DNEY-TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYRMPCPPECP------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L--
TLE---DKELGSGNFGTVKKGYYQ-----MKKVVKTVAVKILK-NE-AN-DPALKDELL-A-EANVMQQL-DNPYIVRMIGICE---------AESWMLVMEMAELGPLNKYLQ----QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT-----QHYAKISDFGLSKAL-RA--DENYYKAQTHGKWPVKWYAPECIN-YYKFSSKSDVWSFGVLMWEAFSYGQKP---------------YRGM-KGSEVTAMLEKGERMGCPAGCP------------------------------REMYDLMNLCWTYDVENRPGFAAVE----LRL
---IKFQDVIGEGNFGQVLKARIK-----KDGLRMDAAIKRMK-EY-AS-KDD-HRDFA-G-ELEVLCKLGHHPNIINLLGACE--H------RGYLYLAIEYAPHGNLLDFLR----KSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE-----NYVAKIADFGLSRGQ------EVY-VKKTMGRLPVRWMAIESLN-YSVYTTNSDVWSYGVLLWEIVSLGGTP---------------YCGM-TCAELYEKLPQGYRLEKPLNCD------------------------------DEVYDLMRQCWREKPYERPSFAQILV---SL-
--L-RLEVKLGQGCFGEVWMGTWN--------GTTKVAIKTLK-PG-TM-MP---EAFL-Q-EAQIMKKL-RHDKLVPLYAVVS---------EEPIYIVTEFMSKGSLLDFLK----EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGE-----NLVCKIADFGLARLI--E--DNEY-TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILQTELVTKGRVP---------------YPGM-VNREVLEQVERGYRMPCPQGCP------------------------------ESLHELMNLCWKKDPDERPTFEYIQSFL----
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