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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FGFR2 203
TK ABL1 261
TK ALK 1116
Other AURKA 133
CMGC CDK2 4
TK EGFR 712
TK EPHA3 621
TK ERBB3 709
TK FGFR1 478
TK HCK 241
TK IGF1R 999
TK INSR 1023
TKL IRAK4 186
TK KIT 589
TK LCK 245
TK MERTK 587
TK MET 1078
Other NEK2 8
AGC PDPK1 82
Other PLK1 53
Other PLK4 12
TK PTK2 422
TK RET 724
TK SRC 270
CAMK STK11 49
STE STK24 24
TK TNK2 150
TK ZAP70 338
----LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-D--D-AT-EKDLS-D-LV-S--EMEMMKMIGKHKNIINLLGACT-Q--DGP-----LYVIVEYASKG--NLREYLR-----ARRPPGMEY------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ-----KCIHRDLAARNVLVTE---NNVMKIADFGLARDI--N-N--IDYY--KKTTNGRLPVKWMAPEALF--DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLL-KEGHRMDKPANCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-------------
----ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E--D-TM-EV--E-E-FL-K--EAAVMKEI-KHPNLVQLLGVCT-R--EPP-----FYIITEFMTYG--NLLDYLR-----EC--------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK-----NFIHRDLAARNCLVGE---NHLVKVADFGLSRLM----T--GDTY--TAHAGAKFPIKWTAPESLA--YNKFSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELL-EKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F-----------
---I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-E--V-CS-EQDEL-D-FL-M--EALIISKF-NHQNIVRCIGVSL-Q--SLP-----RFILLELMAGG--DLKSFLR-----ETRP---------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN-----HFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI--Y-R--ASYY--RKGGCAMLPVKWMPPEAFM--EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSK-SNQEVLEFV-TSGGRMDPPKNCP----------------------------GPVYRIMTQCWQHQPEDRPNFAIILER--I-----------
----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA--QLEKAGV--E-H-QLRR--EVEIQSHL-RHPNILRLYGYFH-D--ATR-----VYLILEYAPLG--TVYRELQ----KLS-----------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLGS---AGELKIADFGWSV------HAPSSRR--TT---LCGTLDYLPPEMIE--GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN----TYQETY-KRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-----------
----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLD--T-ETEGV--P-S-TAIR--EISLLKEL-NHPNIVKLLDVIH-T--ENK-----LYLVFEFLHQ---DLKKFMDA--SALT-----------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLINT---EGAIKLADFGLARAF----GVPVRTY--TH---EVVTLWYRAPEILL-GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-----------
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E--A-TS-PKANK-E-IL-D--EAYVMASV-DNPHVCRLLGICL----TST-----VQLITQLMPFG--CLLDYVR-----EH---------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR-----RLVHRDLAARNVLVKT---PQHVKITDFGLAKLL--G-A--EEKE--YHAEGGKVPIKWMALESIL--HRIYTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSIL-EKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF---------
---I-SIDKVVGAGEFGEVCSGRLK----LPSKKEISVAIKTLK-V--G-YT-EKQRR-D-FL-G--EASIMGQF-DHPNIIRLEGVVT-K--SKP-----VMIVTEYMENG--SLDSFLR-----KH---------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDM-----GYVHRDLAARNILINS---NLVCKVSDFGLSRVL--E-D--DPEA-AYTTRGGKIPIRWTSPEAIA--YRKFTSASDVWSYGIVLWEVMSYGERPYWEM-SNQDVIKAV-DEGYRLPPPMDCP----------------------------AALYQLMLDCWQKDRNNRPKFEQIVSIL-------------
---L-RKLKVLGSGVFGTVHKGVWIP---EGESIKIPVCIKVIE-D--K-SG-RQSFQ-A-VT-D--HMLAIGSL-DHAHIVRLLGLCP----GSS-----LQLVTQYLPLG--SLLDHVR-----QH---------------------------------------------------------------------------RGALGPQLLLNWGVQIAKGMYYLEEH-----GMVHRNLAARNVLLKS---PSQVQVADFGVADLL--P-P--DDKQ--LLYSEAKTPIKWMALESIH--FGKYTHQSDVWSYGVTVWELMTFGAEPYAGL-RLAEVPDLL-EKGERLAQPQICT----------------------------IDVYMVMVKCWMIDENIRPTFKELANE--F-----------
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--D-AT-EKDLS-D-LI-S--EMEMMKMIGKHKNIINLLGACT-Q--DGP-----LYVIVEYASKG--NLREYLQ-----ARRPPGLEY------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK-----KCIHRDLAARNVLVTE---DNVMKIADFGLARDI--H-H--IDYY--KKTTNGRLPVKWMAPEALF--DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLL-KEGHRMDKPSNCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-------------
----LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-P--G-SM-SV--E-A-FL-A--EANVMKTL-QHDKLVKLHAVVT----KEP-----IYIITEFMAKG--SLLDFLK-----SD--------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR-----NYIHRDLRAANILVSA---SLVCKIADFGLARVI----E--DNEY--TAREGAKFPIKWTAPEAIN--FGSFTIKSDVWSFGILLMEIVTYGRIPYPGM-SNPEVIRAL-ERGYRMPRPENCP----------------------------EELYNIMMRCWKNRPEERPTFEYIQSV--L-----------
----ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-E--A-AS-MRERI-E-FL-N--EASVMKEF-NCHHVVRLLGVVS-Q--GQP-----TLVIMELMTRG--DLKSYLR-----SLRPEM------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNAN-----KFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI--Y-E--TDYY--RKGGKGLLPVRWMSPESLK--DGVFTTYSDVWSFGVVLWEIATLAEQPYQGL-SNEQVLRFV-MEGGLLDKPDNCP----------------------------DMLFELMRMCWQYNPKMRPSFLEIISS--I-----------
----ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-E--S-AS-LRERI-E-FL-N--EASVMKGF-TCHHVVRLLGVVS-K--GQP-----TLVVMELMAHG--DLKSYLR-----SLRPEA------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK-----KFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI--Y-E--TDYY--RKGGKGLLPVRWMAPESLK--DGVFTTSSDMWSFGVVLWEITSLAEQPYQGL-SNEQVLKFV-MDGGYLDQPDNCP----------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL-------------
-VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKLAAM--V-DITTE--ELK-QQFD-QEIKVMAKC-QHENLVELLGFSS-D--GDD-----LCLVYVYMPNG--SLLDRLSC-LDGTP-----------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN-----HHIHRDIKSANILLDE---AFTAKISDFGLARASE--KFAQTVMT--SR---IVGTTAYMAPEALR---GEITPKSDIYSFGVVLLEIIT-GLPAVDEH-REPQLLLDI-KEEIEDEEKTIEDYIDKKMNDAD--------------STSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ--------
----LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKMLK-P--S-AH-LTERE-A-LM-S--ELKVLSYLGNHMNIVNLLGACT-I--GGP-----TLVITEYCCYG--DLLNFLR-----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK-----NCIHRDLAARNILLTH---GRITKICDFGLARDI--K-N--DSNY--VVKGNARLPVKWMAPESIF--NCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMI-KEGFRMLSPEHAP----------------------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I-----------
----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q--G-SM-SP--D-A-FL-A--EANLMKQL-QHQRLVRLYAVVT----QEP-----IYIITEYMENG--SLVDFLK-----TP--------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER-----NYIHRDLRAANILVSD---TLSCKIADFGLARLI----E--DNEY--TAREGAKFPIKWTAPEAIN--YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNL-ERGYRMVRPDNCP----------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-----------
---L-ILGKILGEGEFGSVMEGNLK----QEDGTSLKVAVKTMKLD--N-SS-QREIE-E-FL-S--EAACMKDF-SHPNVIRLLGVCI-E--MSSQGIPKPMVILPFMKYG--DLHTYLL-----YSRL----------------------------------------------------------------------ETGPKHIPLQTLLKFMVDIALGMEYLSNR-----NFLHRDLAARNCMLRD---DMTVCVADFGLSKKI--Y-S--GDYY--RQGRIAKMPVKWIAIESLA--DRVYTSKSDVWAFGVTMWEIATRGMTPYPGV-QNHEMYDYL-LHGHRLKQPEDCL----------------------------DELYEIMYSCWRTDPLDRPTFSVLRLQ--L-----------
----VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSLN-R--I-TD-IGEVS-Q-FL-T--EGIIMKDF-SHPNVLSLLGICLRS--EGS-----PLVVLPYMKHG--DLRNFIR-----NE---------------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASK-----KFVHRDLAARNCMLDE---KFTVKVADFGLARDM--Y-D--KEYYSVHNKTGAKLPVKWMALESLQ--TQKFTTKSDVWSFGVLLWELMTRGAPPYPDV-NTFDITVYL-LQGRRLLQPEYCP----------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I-----------
----YEVLYTIGTGSYGRCQKIRRK-------SDGKILVWKELDYG--S-MTEAE--K-Q-MLVS--EVNLLREL-KHPNIVRYYDRII-DRTNTT-----LYIVMEYCEGG--DLASVITKGTKERQ-----------------------------------------------------------------------------YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDG---KQNVKLGDFGLARIL----NHDTSFA--KT---FVGTPYYMSPEQMN--RMSYNEKSDIWSLGCLLYELCA-LMPPFTAF----SQKELA-GKIREGKFRRIPYRY---S----------------------DELNEIITRMLNLKDYHRPSVEEILENPL-I----------
---F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKILEKR--H-IIKEN--K-VPYVTR--ERDVMSRL-DHPFFVKLYFTFQ-D--DEK-----LYFGLSYAKNG--ELLKYIR----KIG-----------------------------------------------------------------------------SFDETCTRFYTAEIVSALEYLHGK-----GIIHRDLKPENILLNE---DMHIQITDFGTAKVLS--PESKQARA--NS---FVGTAQYVSPELLT--EKSACKSSDLWALGCIIYQLVA-GLPPFRAG----NEYLIF-QKIIKLEYDFPEKFF--------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
--YV--RGRFLGKGGFAKCFEISDA-------DTKEVFAGKIVPKS--L-LLKPH--Q-R-EKMS-MEISIHRSL-AHQHVVGFHGFFE-D--NDF-----VFVVLELCRRR--SLLELHK----RRK-----------------------------------------------------------------------------ALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLNE---DLEVKIGDFGLATKV----EYDGERK--KT---LCGTPNYIAPEVLS--KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS----CLKETY-LRIKKNEYSIPKHIN--------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF-----------
---F-KVGNLLGKGSFAGVYRAESI-------HTGLEVAIKMIDKK--A-MYKAG--M-V-QRVQ-NEVKIHCQL-KHPSILELYNYFE-D--SNY-----VYLVLEMCHNG--EMNRYLK---NRVK-----------------------------------------------------------------------------PFSENEARHFMHQIITGMLYLHSH-----GILHRDLTLSNLLLTR---NMNIKIADFGLATQL----KMPHEKH--YT---LCGTPNYISPEIAT--RSAHGLESDVWSLGCMFYTLLI-GRPPFDTD----TVKNTL-NKVVLADYEMPSFLS--------------------------IEAKDLIHQLLRRNPADRLSLSSVLDHPFM-----------
----IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-N--C-TS-DSVRE-K-FL-Q--EALTMRQF-DHPHIVKLIGVIT----ENP-----VWIIMELCTLG--ELRSFLQ-----VR---------------------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLESK-----RFVHRDIAARNVLVSS---NDCVKLGDFGLSRYM----E--DSTY--YKASKGKLPIKWMAPESIN--FRRFTSASDVWMFGVCMWEILMHGVKPFQGV-KNNDVIGRI-ENGERLPMPPNCP----------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL-------------
---L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E--N-AS-PSELR-D-LL-S--EFNVLKQV-NHPHVIKLYGACS-Q--DGP-----LLLIVEYAKYG--SLRGFLR-----ESRKVGPGYLGSG----------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM-----KLVHRDLAARNILVAE---GRKMKISDFGLSRDV--Y-E--EDSY--VKRSQGRIPVKWMAIESLF--DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLL-KTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL-------------
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P--G-TM-SP--E-A-FL-Q--EAQVMKKL-RHEKLVQLYAVVS----EEP-----IYIVTEYMSKG--SLLDFLK-----GE--------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM-----NYVHRDLRAANILVGE---NLVCKVADFGLARLI----E--DNEY--TARQGAKFPIKWTAPEAAL--YGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQV-ERGYRMPCPPECP----------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L-----------
-YLM---GDLLGEGSYGKVKEVLDS-------ETLCRRAVKILKKK--K-LRRIP--N-G-EANVKKEIQLLRRL-RHKNVIQLVDVLY-NEEKQK-----MYMVMEYCVCGMQEMLDSVP-----EK-----------------------------------------------------------------------------RFPVCQAHGYFCQLIDGLEYLHSQ-----GIVHKDIKPGNLLLTT---GGTLKISDLGVAEALH--PFAADDTC--RT---SQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITT-GLYPFEGD----NIYKLF-ENIGKGSYAIPGDCG--------------------------PPLSDLLKGMLEYEPAKRFSIRQIRQHSWF-----------
----FTKLEKIGKGSFGEVFKGIDN-------RTQKVVAIKIIDLE--E-AEDEI--E-D-IQ-Q--EITVLSQC-DSPYVTKYYGSYL-K--DTK-----LWIIMEYLGGG--SALDLLE-----PG-----------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSE-----KKIHRDIKAANVLLSE---HGEVKLADFGVAGQL----TDTQIKR--NT---FVGTPFWMAPEVIK--QSAYDSKADIWSLGITAIELAR-GEPPHSEL-HPMKVLFLI-PKNNPPTLEGNYS----------------------------KPLKEFVEACLNKEPSFRPTAKELLKHKFI-----------
---L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVL-SQ-PEAMD-D-FI-R--EVNAMHSL-DHRNLIRLYGVVL----TPP-----MKMVTELAPLG--SLLDRLR-----KH---------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK-----RFIHRDLAARNLLLAT---RDLVKIGDFGLMRAL-PQ-N--DDHY--VMQEHRKVPFAWCAPESLK--TRTFSHASDTWMFGVTLWEMFTYGQEPWIGL-NGSQILHKIDKEGERLPRPEDCP----------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L-----------
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-Q--G-TE-KADTE-E-MM-R--EAQIMHQL-DNPYIVRLIGVCQ----AEA-----LMLVMEMAGGG--PLHKFLV-----GK---------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEK-----NFVHRDLAARNVLLVN---RHYAKISDFGLSKAL-GA-D--DSYY--TARSAGKWPLKWYAPECIN--FRKFSSRSDVWSYGVTMWEALSYGQKPYKKM-KGPEVMAFI-EQGKRMECPPECP----------------------------PELYALMSDCWIYKWEDRPDFLTVEQR--M-----------
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