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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FGR 203
TK ABL1 261
TK ABL2 288
TKL ACVR1 208
TKL ACVR1B 207
AGC AKT3 148
TK ALK 1116
TK BLK 241
TKL BMPR1A 234
TKL BMPR1B 204
TK BMX 422
TK BTK 402
CAMK CAMK1G 23
Other CAMKK2 165
CMGC CDC2L5 705
CMGC CDK3 4
CMGC CDK9 2.7.11.23
CMGC CDKL3 4
TK CSK 195
TK DDR2 563
TK EGFR 712
TK EPHA4 621
TK EPHA5 675
TK EPHA6 631
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB4 615
TK EPHB6 670
TK ERBB2 720
TK ERBB4 718
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FYN 271
TK HCK 241
CMGC ICK 4
TK IGF1R 999
TK INSRR 979
TKL IRAK4 186
TK JAK2 849
TK JAK3 822
TK KIT 589
TK LCK 245
TK LTK 510
CMGC MAK 4
CMGC MAPK1 13
CAMK MARK1 60
TK MATK 235
TK NTRK1 510
STE PAK6 407
TK PDGFRA 593
TK PDGFRB 600
AGC PKN1 615
AGC PKN2 657
AGC PRKCA 339
AGC PRKCB 342
AGC PRKCD 349
AGC PRKCE 408
AGC PRKCH 355
AGC PRKCQ 380
AGC PRKCZ 252
TK PTK2 422
TK PTK6 191
TKL RAF1 349
TK RET 724
TK ROS1 1945
AGC RPS6KB1 91
AGC RPS6KB2 67
Other SBK1 53
STE SLK 34
TK SRC 270
TK SRMS 230
STE STK24 24
Other STK36 4
TK SYK 371
TKL TGFBR1 205
TK TNK1 116
TK TNK2 150
Other ULK3 14
TK YES1 277
TK ZAP70 338
-------ITLERRLGTGCFGDVWLGTW---N-----------------GST---KVAVKTL---K-P--GTM-SP---K-AFL-E-------------------------EAQVMKLL--R---HDKLVQLYAVVS-------------EEPIYIVTEFMCHGSLLDFLK----NP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERM--------NYIHRDLRAANILVG---E-----RLACKIADFGLARLI-------K--DDEY-NPCQGSKFPIKWTAPEAAL------FGR----FTIKSDVWSFGILLTELITKGR--------------IP---------------YPGM-----NKREV-LEQV-EQ----GYH----MPCPPGCP-------------------------------ASLYE-AMEQTWRLDPEERPT-------FE-YLQSFL----------------
-------ITMKHKLGGGQYGEVYEGVW---K----------------KYSL---TVAVKTL---K-E--DTM-EV---E-EFL-K-------------------------EAAVMKEI--K---HPNLVQLLGVCT--R----------EPPFYIITEFMTYGNLLDYLR----EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVG---E-----NHLVKVADFGLSRLM-------T--GDTY-TAHAGAKFPIKWTAPESLA------YNK----FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQV-YELL-EK----DYR----MERPEGCP-------------------------------EKVYE-LMRACWQWNPSDRPS-------FA-EIHQA--F--------------
-------ITMKHKLGGGQYGEVYVGVW---K----------------KYSL---TVAVKTL---K-E--DTM-EV---E-EFL-K-------------------------EAAVMKEI--K---HPNLVQLLGVCT--L----------EPPFYIVTEYMPYGNLLDYLR----EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVG---E-----NHVVKVADFGLSRLM-------T--GDTY-TAHAGAKFPIKWTAPESLA------YNT----FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQV-YDLL-EK----GYR----MEQPEGCP-------------------------------PKVYE-LMRACWKWSPADRPS-------FA-ETHQA--F--------------
------I-TLLECVGKGRYGEVWRGSW---Q----------------GEN-----VAVKIF---SSR--DEKSWF---R-ET----------------------------ELYNTVML--R---HENILGFIASDM--TSR------HSSTQLWLITHYHEMGSLYDYLQ----LT----------------------------------------------------------------------------------------------------TLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVK---K-----NGQCCIADLGLAVMHSQ---STNQLDVGN-NP---RVGTKRYMAPEVLDETIQVDCFD----SYKRVDIWAFGLVLWEVAR-RMVSNGI----VEDYKPP---------------FYDVVPNDPSFEDM-RKVV-CV----DQQ----RPNIPNRWFSDPTL-------------------------TSLAK-LMKECWYQNPSARLT-------AL-RIKK----TL------------
-----IV--LQEIIGKGRFGEVWRGRW---R----------------GGD-----VAVKIF---SSR--EERSWF---R-EA----------------------------EIYQTVML--R---HENILGFIAADN--KDN------GTWTQLWLVSDYHEHGSLFDYLN----RY----------------------------------------------------------------------------------------------------TVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVK---K-----NGMCAIADLGLAVRHDA---VTDTIDIAP-NQ---RVGTKRYMAPEVLDETINMKHFD----SFKCADIYALGLVYWEIAR-RCNSGGV----HEEYQLP---------------YYDLVPSDPSIEEM-RKVV-CD----QKL----RPNIPNWWQSYEAL-------------------------RVMGK-MMRECWYANGAARLT-------AL-RIKK----TL------------
-----FD--YLKLLGKGTFGKVILVRE---K----------------ASGK---YYAMKIL---KKE--VIIAKD---E-VAHTL------------------------TESRVLKNT--R---HPFLTSLKYSFQ--T----------KDRLCFVMEYVNGGELFFHLS---RER----------------------------------------------------------------------------------------------------VFSEDRTRFYGAEIVSALDYLHSG--------KIVYRDLKLENLMLD---K-----DGHIKITDFGLCKEG-------ITDAATM-KT---FCGTPEYLAPEVLE------DND----YGRAVDWWGLGVVMYEMMC-GR--------------LP---------------FYNQ--------DH-EKLF-EL----ILM----EDIKFPRTLS-----------------------------SDAKS-LLSGLLIKDPNKRLGGG--PDDAK-EIMRHSFF--------------
------I-TLIRGLGHGAFGEVYEGQV---SG-----------MPNDPSPL---QVAVKTL---P-E--VCS-EQD-EL-DFL-M-------------------------EALIISKF--N---HQNIVRCIGVSL--Q----------SLPRFILLELMAGGDLKSFLR----ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN--------HFIHRDIAARNCLLT---CP--GPGRVAKIGDFGMARDI----Y--R--ASYY-RKGGCAMLPVKWMPPEAFM------EGI----FTSKTDTWSFGVLLWEIFSLGY--------------MP---------------YPSK-----SNQEV-LEFV-TS----GGR----MDPPKNCP-------------------------------GPVYR-IMTQCWQHQPEDRPN-------FA-IILER--I--------------
------L-RLVRKLGSGQFGEVWMGYY---K-----------------NNM---KVAIKTL---K-E--GTM-SP---E-AFL-G-------------------------EANVMKAL--Q---HERLVRLYAVVT-------------KEPIYIVTEYMARGCLLDFLK----TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERM--------NSIHRDLRAANILVS---E-----ALCCKIADFGLARII----------DSEY-TAQEGAKFPIKWTAPEAIH------FGV----FTIKADVWSFGVLLMEVVTYGR--------------VP---------------YPGM-----SNPEV-IRNL-ER----GYR----MPRPDTCP-------------------------------PELYRGVIAECWRSRPEERPT-------FE-FLQSV--L--------------
------I-QMVRQVGKGRYGEVWMGKW---R----------------GEK-----VAVKVF---FTT--EEASWF---R-ET----------------------------EIYQTVLM--R---HENILGFIAADI--KGT------GSWTQLYLITDYHENGSLYDFLK----CA----------------------------------------------------------------------------------------------------TLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIK---K-----NGSCCIADLGLAVKFNS---DTNEVDVPL-NT---RVGTKRYMAPEVLDESLNKNHFQ----PYIMADIYSFGLIIWEMAR-RCITGGI----VEEYQLP---------------YYNMVPSDPSYEDM-REVV-CV----KRL----RPIVSNRWNSDECL-------------------------RAVLK-LMSECWAHNPASRLT-------AL-RIKK----TL------------
------I-QMVKQIGKGRYGEVWMGKW---R----------------GEK-----VAVKVF---FTT--EEASWF---R-ET----------------------------EIYQTVLM--R---HENILGFIAADI--KGT------GSWTQLYLITDYHENGSLYDYLK----ST----------------------------------------------------------------------------------------------------TLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVK---K-----NGTCCIADLGLAVKFIS---DTNEVDIPP-NT---RVGTKRYMPPEVLDESLNRNHFQ----SYIMADMYSFGLILWEVAR-RCVSGGIVEEYQLPYHD-------------------LVPSDPSYEDM-REIV-CI----KKL----RPSFPNRWSSDECL-------------------------RQMGK-LMTECWAHNPASRLT-------AL-RVKK----TL------------
-------ITLLKELGSGQFGVVQLGKW---K-----------------GQY---DVAVKMI---K-E--GSM-SE---D-EFF-Q-------------------------EAQTMMKL--S---HPKLVKFYGVCS--K----------EYPIYIVTEYISNGCLLNYLR----SH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESH--------QFIHRDLAARNCLVD---R-----DLCVKVSDFGMTRYV-------L--DDQY-VSSVGTKFPVKWSAPEVFH------YFK----YSSKSDVWAFGILMWEVFSLGK--------------QP---------------YDLY-----DNSQV-VLKV-SQ----GHR----LYRPHLAS-------------------------------DTIYQ-IMYSCWHELPEKRPT-------FQ-QLLSS--I--------------
-------LTFLKELGTGQFGVVKYGKW---R-----------------GQY---DVAIKMI---K-E--GSM-SE---D-EFI-E-------------------------EAKVMMNL--S---HEKLVQLYGVCT--K----------QRPIFIITEYMANGCLLNYLR----EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESK--------QFLHRDLAARNCLVN---D-----QGVVKVSDFGLSRYV-------L--DDEY-TSSVGSKFPVRWSPPEVLM------YSK----FSSKSDIWAFGVLMWEIYSLGK--------------MP---------------YERF-----TNSET-AEHI-AQ----GLR----LYRPHLAS-------------------------------EKVYT-IMYSCWHEKADERPT-------FK-ILLSN--I--------------
-----FI--FMEVLGSGAFSEVFLVKQ---R----------------LTGK---LFALKCI---KKS--PAFRDS---S-LE--N-------------------------EIAVLKKI--K---HENIVTLEDIYE--S----------TTHYYLVMQLVSGGELFDRIL---ERG----------------------------------------------------------------------------------------------------VYTEKDASLVIQQVLSAVKYLHEN--------GIVHRDLKPENLLYLTPEE-----NSKIMITDFGLSK---------MEQNGIM-ST---ACGTPGYVAPEVLA------QKP----YSKAVDCWSIGVITYILLC-GY--------------PP---------------FYEE--------TE-SKLF-EK----IKE----GYYEFESPFWDDIS-------------------------ESAKD-FICHLLEKDPNERYT-------CE-KALSHPWI--------------
-------YTLKDEIGKGSYGVVKLAYN---E----------------NDNT---YYAMKVL---SKK--KLIRQA---G-FPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL--D---HPNVVKLVEVLD--DP--------NEDHLYMVFELVNQGPVMEVPT----LK----------------------------------------------------------------------------------------------------PLSEDQARFYFQDLIKGIEYLHYQ--------KIIHRDIKPSNLLVG---E-----DGHIKIADFGVSNEF-------KGSDALL-SN---TVGTPAFMAPESLS-----ETRKIF--SGKALDVWAMGVTLYCFVF-GQ--------------CP---------------FMDE--------RI-MCLH-SK----IKS----QALEFPDQPDIA---------------------------EDLKD-LITRMLDKNPESRIV-------VP-EIKLHPWV--------------
------F-DIIGIIGEGTYGQVYKARD---K----------------DTGE---MVALKKV---RLD--NEKEGF---P-ITAIR-------------------------EIKILRQL--T---HQSIINMKEIVT--DKEDALDFKKDKGAFYLVFEYMDH-DLMGLLE--SGLV----------------------------------------------------------------------------------------------------HFNENHIKSFMRQLMEGLDYCHKK--------NFLHRDIKCSNILLN---N-----RGQIKLADFGLARLY------SSEESRPY-TN---KVITLWYRPPELLL-----GEER----YTPAIDVWSCGCILGELFT-KK--------------PI---------------FQAN-----QELAQ-LELI-SR----ICG----SPCPAVWPDVIKLPYFNTMKPKKQY--RRKLREEFVFIPAAALD-LFDYMLALDPSKRCT-------AE-QALQCEF-L-------------
-------FQKVEKIGEGTYGVVYKAKN---R----------------ETGQ---LVALKKI---RLD--LEMEGV---P-STAIR-------------------------EISLLKEL--K---HPNIVRLLDVVH--N----------ERKLYLVFEFLSQ-DLKKYMDS-TPGS----------------------------------------------------------------------------------------------------ELPLHLIKSYLFQLLQGVSFCHSH--------RVIHRDLKPQNLLIN---E-----LGAIKLADFGLARAF-------GVPLRTY-TH---EVVTLWYRAPEILL-----GSKF----YTTAVDIWSIGCIFAEMVT-RK--------------AL---------------FPGD-----SEIDQ-LFRI-FR----MLG----TPSEDTWPGVTQLPDYKGSFPKWTR---KGLEEIVPNLEPEGRD-LLMQLLQYDPSQRIT-------AK-TALAHPYF--------------
-------YEKLAKIGQGTFGEVFKARH---R----------------KTGQ---KVALKKV---LME--NEKEGF---P-ITALR-------------------------EIKILQLL--K---HENVVNLIEICR--TKASP--YNRCKGSIYLVFDFCEH-DLAGLLS--NVLV----------------------------------------------------------------------------------------------------KFTLSEIKRVMQMLLNGLYYIHRN--------KILHRDMKAANVLIT---R-----DGVLKLADFGLARAFSL---AKNSQPNRY-TN---RVVTLWYRPPELLL-----GERD----YGPPIDLWGAGCIMAEMWT-RS--------------PI---------------MQGN-----TEQHQ-LALI-SQ----LCG----SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALD-LIDKLLVLDPAQRID-------SD-DALNHDFF--------------
-------YETLGKVGEGSYGTVMKCKH---K----------------NTGQ---IVAIKIF---YER--PEQSVN---K--IAMR-------------------------EIKFLKQF--H---HENLVNLIEVFR--Q----------KKKIHLVFEFIDHTVLDELQH---YCH----------------------------------------------------------------------------------------------------GLESKRLRKYLFQILRAIDYLHSN--------NIIHRDIKPENILVS---Q-----SGITKLCDFGFARTL-------AAPGDIY-TD---YVATRWYRAPELVL-----KDTS----YGKPVDIWALGCMIIEMAT-GN--------------PY---------------LPSS-----SDLDL-LHKI-VL----KVG----N-LSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLAD-IVHACLQIDPADRIS-------SS-DLLHHEYF--------------
-------LKLLQTIGKGEFGDVMLGDY---R------------------GN---KVAVKCI---K-N--DAT-AQ-----AFL-A-------------------------EASVMTQL--R---HSNLVQLLGVIV-EE----------KGGLYIVTEYMAKGSLVDYLR----SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGN--------NFVHRDLAARNVLVS---E-----DNVAKVSDFGLTKEA-------------S-STQDTGKLPVKWTAPEALR------EKK----FSTKSDVWSFGILLWEIYSFGR--------------VP---------------YPRI-----PLKDV-VPRV-EK----GYK----MDAPDGCP-------------------------------PAVYE-VMKNCWHLDAAMRPS-------FL-QLREQL----------------
-------LTFKEKLGEGQFGEVHLCEV---EGMEKFKDKDFALDVSANQPV---LVAVKML---R-A--DAN-KNA-RN-DFL-K-------------------------EIKIMSRL--K---DPNIIHLLAVCI--T----------DDPLCMITEYMENGDLNQFLS----RHEPPN-----------------------------------------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSSL--------NFVHRDLATRNCLVG---K-----NYTIKIADFGMSRNL----Y--S--GDYY-RIQGRAVLPIRWMSWESIL------LGK----FTTASDVWAFGVTLWETFTFCQE-------------QP---------------YSQL-----SDEQV-IENT-GEFFRDQGRQ-TYLPQPAICP-------------------------------DSVYK-LMLSCWRRDTKNRPS-------FQ-EIHL---LL-------------
------F-KKIKVLGSGAFGTVYKGLW---IP------------EGEKVKI---PVAIKEL---R-E--ATS-PKA-NK-EIL-D-------------------------EAYVMASV--D---NPHVCRLLGICL-------------TSTVQLITQLMPFGCLLDYVR----EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR--------RLVHRDLAARNVLVK---T-----PQHVKITDFGLAKLL----G--A--EEKE-YHAEGGKVPIKWMALESIL------HRI----YTHQSDVWSYGVTVWELMTFGS--------------KP---------------YDGI-----PASEI-SSIL-EK----GER----LPQPPICT-------------------------------IDVYM-IMVKCWMIDADSRPK-------FR-ELI----IEF------------
-------IKIEKVIGVGEFGEVCSGRL---K-------------VPGKREI---CVAIKTL---K-A--GYT-DKQ-RR-DFL-S-------------------------EASIMGQF--D---HPNIIHLEGVVT--K----------CKPVMIITEYMENGSLDAFLR----KN--------------------------------------------------------------------------------------------------DGRFTVIQLVGMLRGIGSGMKYLSDM--------SYVHRDLAARNILVN---S-----NLVCKVSDFGMSRVL----E--D--DPEAAYTTRGGKIPIRWTAPEAIA------YRK----FTSASDVWSYGIVMWEVMSYGE--------------RP---------------YWDM-----SNQDV-IKAI-EE----GYR----LPPPMDCP-------------------------------IALHQ-LMLDCWQKERSDRPK-------FG-QIVNML----------------
-------ITIERVIGAGEFGEVCSGRL---K-------------LPGKREL---PVAIKTL---K-V--GYT-EKQ-RR-DFL-G-------------------------EASIMGQF--D---HPNIIHLEGVVT--K----------SKPVMIVTEYMENGSLDTFLK----KN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGISAGMKYLSDM--------GYVHRDLAARNILIN---S-----NLVCKVSDFGLSRVL----E--D--DPEAAYTTRGGKIPIRWTAPEAIA------FRK----FTSASDVWSYGIVMWEVVSYGE--------------RP---------------YWEM-----TNQDV-IKAV-EE----GYR----LPSPMDCP-------------------------------AALYQ-LMLDCWQKERNSRPK-------FD-EIVNML----------------
LPPRIPA----------------------------------------------------------------------------------------------------------------------------------------------GRPVMIVVEYMENGSLDSFLR----KH--------------------------------------------------------------------------------------------------DGHFTVIQLVGMLRGIASGMKYLSDM--------GYVHRDLAARNILVN---S-----NLVCKVSDFGLSRVL----E--D--DPEAAYTTTGGKIPIRWTAPEAIA------YRK----FSSASDAWSYGIVMWEVMSYGE--------------RP---------------YWEM-----SNQDV-ILSI-EE----GYR----LPAPMGCP-------------------------------ASLHQ-LMLHCWQKERNHRPK-------FT-DIVSFL----------------
-------IHIEKIIGSGDSGEVCYGRL---R-------------VPGQRDV---PVAIKAL---K-A--GYT-ERQ-RR-DFL-S-------------------------EASIMGQF--D---HPNIIRLEGVVT--R----------GRLAMIVTEYMENGSLDTFLR----TH--------------------------------------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSDL--------GYVHRDLAARNVLVD---S-----NLVCKVSDFGLSRVL----E--D--DPDAAYTTTGGKIPIRWTAPEAIA------FRT----FSSASDVWSFGVVMWEVLAYGE--------------RP---------------YWNM-----TNRDV-ISSV-EE----GYR----LPAPMGCP-------------------------------HALHQ-LMLDCWHKDRAQRPR-------FS-QIVSVL----------------
------V-KIEEVIGAGEFGEVYKGRL---K-------------LPGKREI---YVAIKTL---K-A--GYS-EKQ-RR-DFL-S-------------------------EASIMGQF--D---HPNIIRLEGVVT--K----------SRPVMIITEFMENGALDSFLR----QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEM--------NYVHRDLAARNILVN---S-----NLVCKVSDFGLSRYLQ-DDT--S--DPTY-TSSLGGKIPVRWTAPEAIA------YRK----FTSASDVWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDV-INAI-EQ----DYR----LPPPMDCP-------------------------------AALHQ-LMLDCWQKDRNSRPR-------FA-EIVNTL----------------
------V-KIEQVIGAGEFGEVCSGHL---K-------------LPGKREI---FVAIKTL---K-S--GYT-EKQ-RR-DFL-S-------------------------EASIMGQF--D---HPNVIHLEGVVT--K----------STPVMIITEFMENGSLDSFLR----QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADM--------NYVHRDLAARNILVN---S-----NLVCKVSDFGLSRFLE-DDT--S--DPTY-TSALGGKIPIRWTAPEAIQ------YRK----FTSASDVWSYGIVMWEVMSYGE--------------RP---------------YWDM-----TNQDV-INAI-EQ----DYR----LPPPMDCP-------------------------------SALHQ-LMLDCWQKDRNHRPK-------FG-QIVNTL----------------
------V-KIEEVIGAGEFGEVCRGRL---K-------------APGKKES---CVAIKTL---K-G--GYT-ERQ-RR-EFL-S-------------------------EASIMGQF--E---HPNIIRLEGVVT--N----------SMPVMILTEFMENGALDSFLR----LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEM--------SYVHRDLAARNILVN---S-----NLVCKVSDFGLSRFLE-ENS--S--DPTY-TSSLGGKIPIRWTAPEAIA------FRK----FTSASDAWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDV-INAI-EQ----DYR----LPPPPDCP-------------------------------TSLHQ-LMLDCWQKDRNARPR-------FP-QVVSAL----------------
-------IKIEEVIGTGSFGEVRQGRL---Q-------------PRGRREQ---TVAIQAL---W-A--GGA-ESL-QM-TFL-G-------------------------RAAVLGQF--Q---HPNILRLEGVVT--K----------SRPLMVLTEFMELGPLDSFLR----QR--------------------------------------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSF--------AFVHRSLSAHSVLVN---S-----HLVCKVARLGHSPQG--------------------PSCLLRWAAPEVIA------HGK----HTTSSDVWSFGILMWEVMSYGE--------------RP---------------YWDM-----SEQEV-LNAI-EQ----EFR----LPPPPGCP-------------------------------PGLHL-LMLDTWQKDRARRPH-------FD-QLVA---AF-------------
------L-RKVKVLGSGAFGTVYKGIW---IP------------DGENVKI---PVAIKVL---R-E--NTS-PKA-NK-EIL-D-------------------------EAYVMAGV--G---SPYVSRLLGICL-------------TSTVQLVTQLMPYGCLLDHVR----EN--------------------------------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLEDV--------RLVHRDLAARNVLVK---S-----PNHVKITDFGLARLL----D--I--DETE-YHADGGKVPIKWMALESIL------RRR----FTHQSDVWSYGVTVWELMTFGA--------------KP---------------YDGI-----PAREI-PDLL-EK----GER----LPQPPICT-------------------------------IDVYM-IMVKCWMIDSECRPR-------FR-ELVSE--F--------------
------L-KRVKVLGSGAFGTVYKGIW---VP------------EGETVKI---PVAIKIL---N-E--TTG-PKA-NV-EFM-D-------------------------EALIMASM--D---HPHLVRLLGVCL-------------SPTIQLVTQLMPHGCLLEYVH----EH--------------------------------------------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEER--------RLVHRDLAARNVLVK---S-----PNHVKITDFGLARLL----E--G--DEKE-YNADGGKMPIKWMALECIH------YRK----FTHQSDVWSYGVTIWELMTFGG--------------KP---------------YDGI-----PTREI-PDLL-EK----GER----LPQPPICT-------------------------------IDVYM-VMVKCWMIDADSRPK-------FK-ELAAE--F--------------
------L-VLGKPLGEGCFGQVVLAEA---IGL---------DKDKPNRVT---KVAVKML---K-S--DAT-EKD-LS-DLI-S-------------------------EMEMMKMIG-K---HKNIINLLGACT--Q----------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--------KCIHRDLAARNVLVT---E-----DNVMKIADFGLARDI----H--H--IDYY-KKTTNGRLPVKWMAPEALF------DRI----YTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGV-----PVEEL-FKLL-KE----GHR----MDKPSNCT-------------------------------NELYM-MMRDCWHAVPSQRPT-------FK-QLVEDL----------------
-------LTLGKPLGEGCFGQVVMAEA---VGI---------DKDKPKEAV---TVAVKML---K-D--DAT-EKD-LS-DLV-S-------------------------EMEMMKMIG-K---HKNIINLLGACT--Q----------DGPLYVIVEYASKGNLREYLR----ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ--------KCIHRDLAARNVLVT---E-----NNVMKIADFGLARDI----N--N--IDYY-KKTTNGRLPVKWMAPEALF------DRV----YTHQSDVWSFGVLMWEIFTLGG--------------SP---------------YPGI-----PVEEL-FKLL-KE----GHR----MDKPANCT-------------------------------NELYM-MMRDCWHAVPSQRPT-------FK-QLVEDL----------------
-------LTLGKPLGEGCFGQVVMAEA---IGI---------DKDRAAKPV---TVAVKML---K-D--DAT-DKD-LS-DLV-S-------------------------EMEMMKMIG-K---HKNIINLLGACT--Q----------GGPLYVLVEYAAKGNLREFLR----ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQ--------KCIHRDLAARNVLVT---E-----DNVMKIADFGLARDV----H--N--LDYY-KKTTNGRLPVKWMAPEALF------DRV----YTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGI-----PVEEL-FKLL-KE----GHR----MDKPANCT-------------------------------HDLYM-IMRECWHAAPSQRPT-------FK-QLVEDL----------------
------L-VLGKPLGEGCFGQVVRAEA---FGM---------DPARPDQAS---TVAVKML---K-D--NAS-DKD-LA-DLV-S-------------------------EMEVMKLIG-R---HKNIINLLGVCT--Q----------EGPLYVIVECAAKGNLREFLR----ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESR--------KCIHRDLAARNVLVT---E-----DNVMKIADFGLARGV----H--H--IDYY-KKTSNGRLPVKWMAPEALF------DRV----YTHQSDVWSFGILLWEIFTLGG--------------SP---------------YPGI-----PVEEL-FSLL-RE----GHR----MDRPPHCP-------------------------------PELYG-LMRECWHAAPSQRPT-------FK-QLVEAL----------------
-------LQLIKRLGNGQFGEVWMGTW---N-----------------GNT---KVAIKTL---K-P--GTM-SP---E-SFL-E-------------------------EAQIMKKL--K---HDKLVQLYAVVS-------------EEPIYIVTEYMNKGSLLDFLK----DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERM--------NYIHRDLRSANILVG---N-----GLICKIADFGLARLI-------E--DNEY-TARQGAKFPIKWTAPEAAL------YGR----FTIKSDVWSFGILLTELVTKGR--------------VP---------------YPGM-----NNREV-LEQV-ER----GYR----MPCPQDCP-------------------------------ISLHE-LMIHCWKKDPEERPT-------FE-YLQSFL----------------
-------LKLEKKLGAGQFGEVWMATY---N-----------------KHT---KVAVKTM---K-P--GSM-SV---E-AFL-A-------------------------EANVMKTL--Q---HDKLVKLHAVVT-------------KEPIYIITEFMAKGSLLDFLK----SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR--------NYIHRDLRAANILVS---A-----SLVCKIADFGLARVI-------E--DNEY-TAREGAKFPIKWTAPEAIN------FGS----FTIKSDVWSFGILLMEIVTYGR--------------IP---------------YPGM-----SNPEV-IRAL-ER----GYR----MPRPENCP-------------------------------EELYN-IMMRCWKNRPEERPT-------FE-YIQSV--L--------------
-------YTTIRQLGDGTYGSVLLGRS---I----------------ESGE---LIAIKKM---KRK--FYSWEE---C--MNLR-------------------------EVKSLKKL--N---HANVVKLKEVIR--E----------NDHLYFIFEYMKE-NLYQLIK--ERNK----------------------------------------------------------------------------------------------------LFPESAIRNIMYQILQGLAFIHKH--------GFFHRDLKPENLLCM---G-----PELVKIADFGLARE--------IRSKPPY-TD---YVSTRWYRAPEVLL-----RSTN----YSSPIDVWAVGCIMAEVYT-LR--------------PL---------------FPGA-----SEIDT-IFKI-CQ----VLG----TPKKTDWPEGYQLSSAMNFRWPQCV--PNNLKTLIPNASSEAVQ-LLRDMLQWDPKKRPT-------AS-QALRYPYF--------------
-------ITMSRELGQGSFGMVYEGVA---KG-----------VVKDEPET---RVAIKTV---N-E--AAS-MRE-RI-EFL-N-------------------------EASVMKEF--N---CHHVVRLLGVVS--Q----------GQPTLVIMELMTRGDLKSYLR----SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNAN--------KFVHRDLAARNCMVA---E-----DFTVKIGDFGMTRDI----Y--E--TDYY-RKGGKGLLPVRWMSPESLK------DGV----FTTYSDVWSFGVVLWEIATLAE--------------QP---------------YQGL-----SNEQV-LRFV-ME----GGL----LDKPDNCP-------------------------------DMLFE-LMRMCWQYNPKMRPS-------FL-EIISS--I--------------
------I-SIIRELGQGSFGMVYEGLA---RG-----------LEAGEEST---PVALKTV---N-E--LAS-PRE-CI-EFL-K-------------------------EASVMKAF--K---CHHVVRLLGVVS--Q----------GQPTLVIMELMTRGDLKSHLR----SLRPEA-----------------------------------------------------------------------------------------ENNPGLPQPALGEMIQMAGEIADGMAYLAAN--------KFVHRDLAARNCMVS---Q-----DFTVKIGDFGMTRDV----Y--E--TDYY-RKGGKGLLPVRWMAPESLK------DGI----FTTHSDVWSFGVVLWEIVTLAE--------------QP---------------YQGL-----SNEQV-LKFV-MD----GGV----LEELEGCP-------------------------------LQLQE-LMSRCWQPNPRLRPS-------FT-HILD---SI-------------
----VGG----NKMGEGGFGVVYKGYV---N----------------NTT-----VAVKKL---AAM--VDITTE---ELKQQFD------------------------QEIKVMAKC--Q---HENLVELLGFSS--D----------GDDLCLVYVYMPNGSLLDRLSCLDGTP----------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN--------HHIHRDIKSANILLD---E-----AFTAKISDFGLARASE-----KFAQTVMT-SR---IVGTTAYMAPEALR-------GE----ITPKSDIYSFGVVLLEIIT-GL--------------PA---------------VDEH-----REPQL-LLDI-KE----EIE----DEEKTIEDYIDKKMNDAD-----------------STSVEAMYS-VASQCLHEKKNKRPD-------IK-KVQQ----LLQ-----------
-------LKFLQQLGKGNFGSVEMCRY---DP------------LQDNTGE---VVAVKKL---Q-H--STE--EH-LR-DFE-R-------------------------EIEILKSL--Q---HDNIVKYKGVCYSAG----------RRNLKLIMEYLPYGSLRDYLQ----KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK--------RYIHRDLATRNILVE---N-----ENRVKIGDFGLTKVL---PQ--D--KEYY-KVKEPGESPIFWYAPESLT------ESK----FSVASDVWSFGVVLYELFTYIE--------------KSKSPPAEFMRMIGNDKQGQM-----IVFHL-IELL-KN----NGR----LPRPDGCP-------------------------------DEIYM-IMTECWNNNVNQRPS-------FR-DLA----LRV------------
------L-KYISQLGKGNFGSVELCRY---DP------------LGDNTGA---LVAVKQL---Q-H--SGP-DQ--QR-DFQ-R-------------------------EIQILKAL--H---SDFIVKYRGVSYGPG----------RQSLRLVMEYLPSGCLRDFLQ----RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSR--------RCVHRDLAARNILVE---S-----EAHVKIADFGLAKLL---PL--D--KDYY-VVREPGQSPIFWYAPESLS------DNI----FSRQSDVWSFGVVLYELFTYCD--------------KSCSPSAE--FLRMMGCERDV-P---ALCRL-LELL-EE----GQR----LPAPPACP-------------------------------AEVHE-LMKLCWAPSPQDRPS-------FS-ALGP---QL-------------
-------LSFGKTLGAGAFGKVVEATA---YG-----------LIKSDAAM---TVAVKML---K-P--SAH-LTE-RE-ALM-S-------------------------ELKVLSYLG-N---HMNIVNLLGACT--I----------GGPTLVITEYCCYGDLLNFLR----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK--------NCIHRDLAARNILLT---H-----GRITKICDFGLARDI----K--N--DSNY-VVKGNARLPVKWMAPESIF------NCV----YTFESDVWSYGIFLWELFSLGS--------------SP---------------YPGM-P---VDSKF-YKMI-KE----GFR----MLSPEHAP-------------------------------AEMYD-IMKTCWDADPLKRPT-------FK-QIVQL--I--------------
-------LKLVERLGAGQFGEVWMGYY---N-----------------GHT---KVAVKSL---K-Q--GSM-SP---D-AFL-A-------------------------EANLMKQL--Q---HQRLVRLYAVVT-------------QEPIYIITEYMENGSLVDFLK----TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVS---D-----TLSCKIADFGLARLI-------E--DNEY-TAREGAKFPIKWTAPEAIN------YGT----FTIKSDVWSFGILLTEIVTHGR--------------IP---------------YPGM-----TNPEV-IQNL-ER----GYR----MVRPDNCP-------------------------------EELYQ-LMRLCWKERPEDRPT-------FD-YLRSV--L--------------
------V-TLLRALGHGAFGEVYEGLV---IG-----------LPGDSSPL---QVAIKTL---P-E--LCS-PQD-EL-DFL-M-------------------------EALIISKF--R---HQNIVRCVGLSL--R----------ATPRLILLELMSGGDMKSFLR----HSRP--------------------------------------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEEN--------HFIHRDIAARNCLLS---CA--GPSRVAKIGDFGMARDI----Y--R--ASYY-RRGDRALLPVKWMPPEAFL------EGI----FTSKTDSWSFGVLLWEIFSLGY--------------MP---------------YPGR-----TNQEV-LDFV-VG----GGR----MDPPRGCP-------------------------------GPVYR-IMTQCWQHEPELRPS-------FA-SILERL----------------
-------YTTMRQLGDGTYGSVLMGKS---N----------------ESGE---LVAIKRM---KRK--FYSWDE---C-M-NLR-------------------------EVKSLKKL--N---HANVIKLKEVIR--E----------NDHLYFIFEYMKE-NLYQLMK--DRNK----------------------------------------------------------------------------------------------------LFPESVIRNIMYQILQGLAFIHKH--------GFFHRDMKPENLLCM---G-----PELVKIADFGLARE--------LRSQPPY-TD---YVSTRWYRAPEVLL-----RSSV----YSSPIDVWAVGSIMAELYM-LR--------------PL---------------FPGT-----SEVDE-IFKI-CQ----VLG----TPKKSDWPEGYQLASSMNFRFPQCV--PINLKTLIPNASNEAIQ-LMTEMLNWDPKKRPT-------AS-QALKHPYF--------------
-------YTNLSYIGEGAYGMVCSAYD---N----------------VNKV---RVAIKKI---SPF--EHQTYC---Q-RT-LR-------------------------EIKILLRF--R---HENIIGINDIIR--APT-----IEQMKDVYIVQDLMET-DLYKLLK----TQ----------------------------------------------------------------------------------------------------HLSNDHICYFLYQILRGLKYIHSA--------NVLHRDLKPSNLLLN---T-----TCDLKICDFGLARVAD----PDHDHTGFL-TE---YVATRWYRAPEIML-----NSKG----YTKSIDIWSVGCILAEMLS-NR--------------PI---------------FPGK-----HYLDQ-LNHI-LG----ILG----SPSQEDLNCIINLKARNYLLSLPHKN-KVPWNRLFPNADSKALD-LLDKMLTFNPHKRIE-------VE-QALAHPYL--------------
-------YRLQKTIGKGNFAKVKLARH---V----------------LTGR---EVAVKII---DKT--QLNPTS---L-QKLFR-------------------------EVRIMKIL--N---HPNIVKLFEVIE--T----------EKTLYLVMEYASGGEVFDYLV---AHG----------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVQYCHQK--------YIVHRDLKAENLLLD---G-----DMNIKIADFGFSNE--------FTVGNKL-DT---FCGSPPYAAPELFQ-----GKKY----DGPEVDVWSLGVILYTLVS-GS--------------LP---------------FDGQ--------NL-KELR-ER----VLR----GKYRIPFYMS-----------------------------TDCEN-LLKKLLVLNPIKRGS-------LE-QIMKDRWM--------------
-------LTLGAQIGEGEFGAVLQGEY---L------------------GQ---KVAVKNI---K-C--DVT-AQ-----AFL-D-------------------------ETAVMTKM--Q---HENLVRLLGVIL-------------HQGLYIVMEHVSKGNLVNFLR----TR-------------------------------------------------------------------------------------------------GRALVNTAQLLQFSLHVAEGMEYLESK--------KLVHRDLAARNILVS---E-----DLVAKVSDFGLAKAE-------------R-KGLDSSRLPVKWTAPEALK------HGK----FTSKSDVWSFGVLLWEVFSYGR--------------AP---------------YPKM-----SLKEV-SEAV-EK----GYR----MEPPEGCP-------------------------------GPVHV-LMSSCWEAEPARRPP-------FR-KLAEKL----------------
-----IV--LKWELGEGAFGKVFLAEC---HN-----------LLPEQDKM---LVAVKAL---K-E--ASE-SA--RQ-DFQ-R-------------------------EAELLTML--Q---HQHIVRFFGVCT--E----------GRPLLMVFEYMRHGDLNRFLR----SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGL--------HFVHRDLATRNCLVG---Q-----GLVVKIGDFGMSRDI----Y--S--TDYY-RVGGRTMLPIRWMPPESIL------YRK----FTTESDVWSFGVVLWEIFTYGK--------------QP---------------WYQL-----SNTEA-IDCI-TQ----GRE----LERPRACP-------------------------------PEVYA-IMRGCWQREPQQRHS-------IK-DVHARL----------------
---DSYV-----KIGEGSTGIVCLARE---K----------------HSGR---QVAVKMM---DLR--KQQRRE---L---LFN-------------------------EVVIMRDY--Q---HFNVVEMYKSYL--V----------GEELWVLMEFLQGGALTDIVS----QV----------------------------------------------------------------------------------------------------RLNEEQIATVCEAVLQALAYLHAQ--------GVIHRDIKSDSILLT---L-----DGRVKLSDFGFCAQI-------SKDVPKR-KS---LVGTPYWMAPEVIS------RSL----YATEVDIWSLGIMVIEMVD-GE--------------PP---------------YFSD-----SPVQA-MKRL-RD----SPP----PKLKNSHKVS-----------------------------PVLRD-FLERMLVRDPQERAT-------AQ-ELLDHPFL--------------
------L-VLGRVLGSGAFGKVVEGTA---YG-----------LSRSQPVM---KVAVKML---K-P--TAR-SSE-KQ-ALM-S-------------------------ELKIMTHLG-P---HLNIVNLLGACT--K----------SGPIYIITEYCFYGDLVNYLH----KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASK--------NCVHRDLAARNVLLA---Q-----GKIVKICDFGLARDI----M--H--DSNY-VSKGSTFLPVKWMAPESIF------DNL----YTTLSDVWSYGILLWEIFSLGG--------------TP---------------YPGM-M---VDSTF-YNKI-KS----GYR----MAKPDHAT-------------------------------SEVYE-IMVKCWNSEPEKRPS-------FY-HLSE---IV-------------
------L-VLGRTLGSGAFGQVVEATA---HG-----------LSHSQATM---KVAVKML---K-S--TAR-SSE-KQ-ALM-S-------------------------ELKIMSHLG-P---HLNVVNLLGACT--K----------GGPIYIITEYCRYGDLVDYLH----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASK--------NCVHRDLAARNVLIC---E-----GKLVKICDFGLARDI----M--R--DSNY-ISKGSTFLPLKWMAPESIF------NSL----YTTLSDVWSFGILLWEIFTLGG--------------TP---------------YPEL-P---MNEQF-YNAI-KR----GYR----MAQPAHAS-------------------------------DEIYE-IMQKCWEEKFEIRPP-------FS-QLVL---LL-------------
------F-KFLAVLGRGHFGKVLLSEF---R----------------PSGE---LFAIKAL---KKG--DIVARD---E-VESLM------------------------CEKRILAAV--TSAGHPFLVNLFGCFQ--T----------PEHVCFVMEYSAGGDLMLHIH----SD----------------------------------------------------------------------------------------------------VFSEPRAIFYSACVVLGLQFLHEH--------KIVYRDLKLDNLLLD---T-----EGYVKIADFGLCKEG-------MGYGDRT-ST---FCGTPEFLAPEVLT------DTS----YTRAVDWWGLGVLLYEMLV-GE--------------SP---------------FPGD--------DE-EEVF-DS----IVN----DEVRYPRFLS-----------------------------AEAIG-IMRRLLRRNPERRLGSS--ERDAE-DVKKQPFF--------------
-----FR--CCAVLGRGHFGKVLLAEY---K----------------NTNE---MFAIKAL---KKG--DIVARD---E-VDSLM------------------------CEKRIFETV--NSVRHPFLVNLFACFQ--T----------KEHVCFVMEYAAGGDLMMHIH----TD----------------------------------------------------------------------------------------------------VFSEPRAVFYAACVVLGLQYLHEH--------KIVYRDLKLDNLLLD---T-----EGFVKIADFGLCKEG-------MGYGDRT-ST---FCGTPEFLAPEVLT------ETS----YTRAVDWWGLGVLIYEMLV-GE--------------SP---------------FPGD--------DE-EEVF-DS----IVN----DEVRYPRFLS-----------------------------TEAIS-IMRRLLRRNPERRLGAS--EKDAE-DVKKHPFF--------------
------F-NFLMVLGKGSFGKVMLADR---K----------------GTEE---LYAIKIL---KKD--VVIQDD---D-VECTM------------------------VEKRVLALL-DK---PPFLTQLHSCFQ--T----------VDRLYFVMEYVNGGDLMYHIQ---QVG----------------------------------------------------------------------------------------------------KFKEPQAVFYAAEISIGLFFLHKR--------GIIYRDLKLDNVMLD---S-----EGHIKIADFGMCKEH-------MMDGVTT-RT---FCGTPDYIAPEIIA------YQP----YGKSVDWWAYGVLLYEMLA-GQ--------------PP---------------FDGE--------DE-DELF-QS----IME----HNVSYPKSLS-----------------------------KEAVS-VCKGLMTKHPAKRLG-------C----------GPEGERDVREHAFF
------F-NFLMVLGKGSFGKVMLSER---K----------------GTDE---LYAVKIL---KKD--VVIQDD---D-VECTM------------------------VEKRVLALP-GK---PPFLTQLHSCFQ--T----------MDRLYFVMEYVNGGDLMYHIQ---QVG----------------------------------------------------------------------------------------------------RFKEPHAVFYAAEIAIGLFFLQSK--------GIIYRDLKLDNVMLD---S-----EGHIKIADFGMCKEN-------IWDGVTT-KT---FCGTPDYIAPEIIA------YQP----YGKSVDWWAFGVLLYEMLA-GQ--------------AP---------------FEGE--------DE-DELF-QS----IME----HNVAYPKSMS-----------------------------KEAVA-ICKGLMTKHPGKRLG-------C----------GPEGERDIKEHAFF
-----FI--FHKVLGKGSFGKVLLGEL---K----------------GRGE---YFAIKAL---KKD--VVLIDD---D-VECTM------------------------VEKRVLTLA-AE---NPFLTHLICTFQ--T----------KDHLFFVMEFLNGGDLMYHIQ---DKG----------------------------------------------------------------------------------------------------RFELYRATFYAAEIMCGLQFLHSK--------GIIYRDLKLDNVLLD---R-----DGHIKIADFGMCKEN-------IFGESRA-ST---FCGTPDYIAPEILQ------GLK----YTFSVDWWSFGVLLYEMLI-GQ--------------SP---------------FHGD--------DE-DELF-ES----IRV----DTPHYPRWIT-----------------------------KESKD-ILEKLFEREPTKRLG------VTG-NIKIHPFF--------------
------F-NFIKVLGKGSFGKVMLAEL---K----------------GKDE---VYAVKVL---KKD--VILQDD---D-VDCTM------------------------TEKRILALA-RK---HPYLTQLYCCFQ--T----------KDRLFFVMEYVNGGDLMFQIQ---RSR----------------------------------------------------------------------------------------------------KFDEPRSRFYAAEVTSALMFLHQH--------GVIYRDLKLDNILLD---A-----EGHCKLADFGMCKEG-------ILNGVTT-TT---FCGTPDYIAPEILQ------ELE----YGPSVDWWALGVLMYEMMA-GQ--------------PP---------------FEAD--------NE-DDLF-ES----ILH----DDVLYPVWLS-----------------------------KEAVS-ILKAFMTKNPHKRLGCVASQNGED-AIKQHP--FF------------
-------FEFIRVLGKGSFGKVMLARV---K----------------ETGD---LYAVKVL---KKD--VILQDD---D-VECTM------------------------TEKRILSLA-RN---HPFLTQLFCCFQ--T----------PDRLFFVMEFVNGGDLMFHIQ---KSR----------------------------------------------------------------------------------------------------RFDEARARFYAAEIISALMFLHDK--------GIIYRDLKLDNVLLD---H-----EGHCKLADFGMCKEG-------ICNGVTT-AT---FCGTPDYIAPEILQ------EML----YGPAVDWWAMGVLLYEMLC-GH--------------AP---------------FEAE--------NE-DDLF-EA----ILN----DEVVYPTWLH-----------------------------EDATG-ILKSFMTKNPTMRLGSLT-QGGEH-AILRHPF-F-------------
-----FI--LHKMLGKGSFGKVFLAEF---K----------------KTNQ---FFAIKAL---KKD--VVLMDD---D-VECTM------------------------VEKRVLSLA-WE---HPFLTHMFCTFQ--T----------KENLFFVMEYLNGGDLMYHIQ---SCH----------------------------------------------------------------------------------------------------KFDLSRATFYAAEIILGLQFLHSK--------GIVYRDLKLDNILLD---K-----DGHIKIADFGMCKEN-------MLGDAKT-NT---FCGTPDYIAPEILL------GQK----YNHSVDWWSFGVLLYEMLI-GQ--------------SP---------------FHGQ--------DE-EELF-HS----IRM----DNPFYPRWLE-----------------------------KEAKD-LLVKLFVREPEKRLG-------VRGDIRQHPLF--------------
------F-DLIRVIGRGSYAKVLLVRL---K----------------KNDQ---IYAMKVV---KKE--LVHDDE---D-IDWVQ------------------------TEKHVFEQA-SS---NPFLVGLHSCFQ--T----------TSRLFLVIEYVNGGDLMFHMQ---RQR----------------------------------------------------------------------------------------------------KLPEEHARFYAAEICIALNFLHER--------GIIYRDLKLDNVLLD---A-----DGHIKLTDYGMCKEG-------LGPGDTT-ST---FCGTPNYIAPEILR------GEE----YGFSVDWWALGVLMFEMMA-GR--------------SP---------------FDIITD-NPDMNTE-DYLF-QV----ILE----KPIRIPRFLS-----------------------------VKASH-VLKGFLNKDPKERLGCRP-QTGF----------SDIKSHAFF-----
-------IELGRCIGEGQFGDVHQGIY---M-------------SPENPAL---AVAIKTC---K-N--CTS-DSV-RE-KFL-Q-------------------------EALTMRQF--D---HPHIVKLIGVIT-------------ENPVWIIMELCTLGELRSFLQ----VR--------------------------------------------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLESK--------RFVHRDIAARNVLVS---S-----NDCVKLGDFGLSRYM-------E--DSTY-YKASKGKLPIKWMAPESIN------FRR----FTSASDVWMFGVCMWEILMHGV--------------KP---------------FQGV-----KNNDV-IGRI-EN----GER----LPMPPNCP-------------------------------PTLYS-LMTKCWAYDPSRRPR-------FT-ELKAQL----------------
------F-TLCRKLGSGYFGEVFEGLW---K-----------------DRV---QVAIKVI---S-R--DNL-LH--QQ-MLQ-S-------------------------EIQAMKKL--R---HKHILALYAVVS--V----------GDPVYIITELMAKGSLLELLR----DS-------------------------------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQ--------NYIHRDLAARNILVG---E-----NTLCKVGDFGLARLI----------KEDV-YLSHDHNIPYKWTAPEALS------RGH----YSTKSDVWSFGILLHEMFSRGQ--------------VP---------------YPGM-----SNHEA-FLRV-DA----GYR----MPCPLECP-------------------------------PSVHK-LMLTCWCRDPEQRPC-------FK-ALRERL----------------
-----VM--LSTRIGSGSFGTVYKGKW---H-------------------G---DVAVKIL---K-V-VDPT-PEQ-FQ-AFR-N-------------------------EVAVLRKT--R---HVNILLFMGYMT-------------KDNLAIVTQWCEGSSLYKHLH----VQ--------------------------------------------------------------------------------------------------ETKFQMFQLIDIARQTAQGMDYLHAK--------NIIHRDMKSNNIFLH---E-----GLTVKIGDFGLATVK----S--R--WSGS-QQVEQPTGSVLWMAPEVIR------MQDN-NPFSFQSDVYSYGIVLYELMT-GE--------------LP---------------YSHI-N---NRDQI-IFMV-GR----GYASPDLSKLYKNCP-------------------------------KAMKR-LVADCVKKVKEERPL-------FP-QILSS--I--------------
------L-VLGKTLGEGEFGKVVKATA---FH-----------LKGRAGYT---TVAVKML---K-E--NAS-PSE-LR-DLL-S-------------------------EFNVLKQV--N---HPHVIKLYGACS--Q----------DGPLLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM--------KLVHRDLAARNILVA---E-----GRKMKISDFGLSRDV----Y--E--EDSY-VKRSQGRIPVKWMAIESLF------DHI----YTTQSDVWSFGVLLWEIVTLGG--------------NP---------------YPGI-----PPERL-FNLL-KT----GHR----MERPDNCS-------------------------------EEMYR-LMLQCWKQEPDKRPV-------FA-DISKDL----------------
-----LT--LRLLLGSGAFGEVYEGTA---VDI----------LGVGSGEI---KVAVKTL---K-K--GST-DQE-KI-EFL-K-------------------------EAHLMSKF--N---HPNILKQLGVCL--L----------NEPQYIILELMEGGDLLTYLR----KARM--------------------------------------------------------------------------------------------ATFYGPLLTLVDLVDLCVDISKGCVYLERM--------HFIHRDLAARNCLVS---VKDYTSPRIVKIGDFGLARDI----Y--K--NDYY-RKRGEGLLPVRWMAPESLM------DGI----FTTQSDVWSFGILIWEILTLGH--------------QP---------------YPAH-----SNLDV-LNYV-QT----GGR----LEPPRNCP-------------------------------DDLWN-LMTQCWAQEPDQRPT-------FH-RIQDQL----------------
-------FELLRVLGKGGYGKVFQVRKVTGA----------------NTGK---IFAMKVL---KKA--MIVRNA---K-DTAHTK-----------------------AERNILEEV--K---HPFIVDLIYAFQ--T----------GGKLYLILEYLSGGELFMQLE---REG----------------------------------------------------------------------------------------------------IFMEDTACFYLAEISMALGHLHQK--------GIIYRDLKPENIMLN---H-----QGHVKLTDFGLCKES-------IHDGTVT-HT---FCGTIEYMAPEILM------RSG----HNRAVDWWSLGALMYDMLT-GA--------------PP---------------FTGE--------NR-KKTI-DK----ILK----CKLNLPPYLT-----------------------------QEARD-LLKKLLKRNAASRLGAG--PGDAG-EVQAHPFF--------------
-------FELLRVLGKGGYGKVFQVRK---V----------------QGTNLGKIYAMKVL---RKA--KIVRNA---K-DTAHTR-----------------------AERNILESV--K---HPFIVELAYAFQ--T----------GGKLYLILECLSGGELFTHLE---REG----------------------------------------------------------------------------------------------------IFLEDTACFYLAEITLALGHLHSQ--------GIIYRDLKPENIMLS---S-----QGHIKLTDFGLCKES-------IHEGAVT-HT---FCGTIEYMAPEILV------RSG----HNRAVDWWSLGALMYDMLT-GS--------------PP---------------FTAE--------NR-KKTM-DK----IIR----GKLALPPYLT-----------------------------PDARD-LVKKFLKRNPSQRIGGG--PGDAA-DVQRHPFF--------------
-------YELVRELGKGTYGKVDLVVY---K----------------GTGT---KMALKFV---NKS--KTKLKN---F----LR-------------------------EVSITNSL-SS---SPFIIKVFDVVF--E---------TEDCYVFAQEYAPAGDLFDIIP---PQV----------------------------------------------------------------------------------------------------GLPEDTVKRCVQQLGLALDFMHGR--------QLVHRDIKPENVLLFD-RE-----CRRVKLADFGMTR----------RVGCRV-KR---VSGTIPYTAPEVCQAG-RADGLA----VDTGVDVWAFGVLIFCVLT-GN--------------FP---------------WEAA-----SGADAFFEEF-VR----WQR----GRLPGLPSQWRRFT-------------------------EPALR-MFQRLLALEPERRGP-------AK-EVF-----RFLKH---------
-------WEIIGELGDGAFGKVYKAQN---K----------------ETSV---LAAAKVI---DTK--SEEELE---D-YM--V-------------------------EIDILASC--D---HPNIVKLLDAFY--Y----------ENNLWILIEFCAGGAVDAVML--ELER----------------------------------------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHDN--------KIIHRDLKAGNILFT---L-----DGDIKLADFGVSAKN-------TRTIQRR-DS---FIGTPYWMAPEVVMCE-TSKDRP----YDYKADVWSLGITLIEMAE-IE--------------PP---------------HHEL-----NPMRV-LLKI-AK----SEP----PTLAQPSRWS-----------------------------SNFKD-FLKKCLEKNVDARWT-------TS-QLLQHPFV--------------
------L-RLEVKLGQGCFGEVWMGTW---N-----------------GTT---RVAIKTL---K-P--GTM-SP---E-AFL-Q-------------------------EAQVMKKL--R---HEKLVQLYAVVS-------------EEPIYIVTEYMSKGSLLDFLK----GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVG---E-----NLVCKVADFGLARLI-------E--DNEY-TARQGAKFPIKWTAPEAAL------YGR----FTIKSDVWSFGILLTELTTKGR--------------VP---------------YPGM-----VNREV-LDQV-ER----GYR----MPCPPECP-------------------------------ESLHD-LMCQCWRKEPEERPT-------FE-YLQAF--L--------------
-----FA--LGRKLGEGYFGEVWEGLW---L-----------------GSL---PVAIKVI---K-S--ANM-K---LT-DLA-K-------------------------EIQTLKGL--R---HERLIRLHAVCS--G----------GEPVYIVTELMRKGNLQAFLG----TP-------------------------------------------------------------------------------------------------EGRALRLPPLLGFACQVAEGMSYLEEQ--------RVVHRDLAARNVLVD---D-----GLACKVADFGLARLL-------K--DDIY-SPSSSSKIPVKWTAPEAAN------YRV----FSQKSDVWSFGVLLHEVFTYGQ--------------CP---------------YEGM-----TNHET-LQQI-MR----GYR----LPRPAACP-------------------------------AEVYV-LMLECWRSSPEERPS-------FA-TLREKL----------------
-------FTKLEKIGKGSFGEVFKGID---N----------------RTQK---VVAIKII---DLE--EAEDEI---E-DIQ-Q-------------------------EITVLSQC--D---SPYVTKYYGSYL--K----------DTKLWIIMEYLGGGSALDLLE----PG----------------------------------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSE--------KKIHRDIKAANVLLS---E-----HGEVKLADFGVAGQL-------TDTQIKR-NT---FVGTPFWMAPEVIK------QSA----YDSKADIWSLGITAIELAR-GE--------------PP---------------HSEL-----HPMKV-LFLI-PK----NNP----PTLEGNYS-------------------------------KPLKE-FVEACLNKEPSFRPT-------AK-ELLKHKFI--------------
-------YHVLEMIGEGSFGRVYKGRR---K----------------YSAQ---VVALKFI---PKL--GRSEKE---L-RNLQR-------------------------EIEIMRGL--R---HPNIVHMLDSFE--T----------DKEVVVVTDYAEG-ELFQILE---DDG----------------------------------------------------------------------------------------------------KLPEDQVQAIAAQLVSALYYLHSH--------RILHRDMKPQNILLA---K-----GGGIKLCDFGFARAM-------STNTMVL-TS---IKGTPLYMSPELVE------ERP----YDHTADLWSVGCILYELAV-GT--------------PP---------------FYAT--------SI-FQLV-SL----ILK----DPVRWPSTIS-----------------------------PCFKN-FLQGLLTKDPRQRLS-------WP-DLLYHPFI--------------
----TLE---DKELGSGNFGTVKKGYY---Q--------------MKKVVK---TVAVKIL---K-N--EAN-DPALKD-ELL-A-------------------------EANVMQQL--D---NPYIVRMIGICE-------------AESWMLVMEMAELGPLNKYLQ----QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEES--------NFVHRDLAARNVLLV---T-----QHYAKISDFGLSKAL----R--A--DENYYKAQTHGKWPVKWYAPECIN------YYK----FSSKSDVWSFGVLMWEAFSYGQ--------------KP---------------YRGM-----KGSEV-TAML-EK----GER----MGCPAGCP-------------------------------REMYD-LMNLCWTYDVENRPG-------FA-AVE----LRL------------
-----IV--LQESIGKGRFGEVWRGKW---R----------------GEE-----VAVKIF---SSR--EERSWF---R-EA----------------------------EIYQTVML--R---HENILGFIAADN--KDN------GTWTQLWLVSDYHEHGSLFDYLN----RY----------------------------------------------------------------------------------------------------TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVK---K-----NGTCCIADLGLAVRHDS---ATDTIDIAP-NH---RVGTKRYMAPEVLDDSINMKHFE----SFKRADIYAMGLVFWEIAR-RCSIGGI----HEDYQLP---------------YYDLVPSDPSVEEM-RKVV-CE----QKL----RPNIPNRWQSCEAL-------------------------RVMAK-IMRECWYANGAARLT-------AL-RIKK----TL------------
----VCR---GELLGSGCFGVVHRGLW---T-------------LPSGKSV---PVAVKSLRVGP-E--GPM-GTE-LG-DFL-R-------------------------EVSVMMNL--E---HPHVLRLHGLVL-------------GQPLQMVMELAPLGSLHARLT----AP------------------------------------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGAR--------GLVHRDLATRNLLLA---S-----PRTIKVADFGLVRPL---GG--A--RGRY-VMGGPRPIPYAWCAPESLR------HGA----FSSASDVWMFGVTLWEMFSGGE--------------EP---------------WAGV-----PPYLI-LQRL-ED----RAR----LPRPPLCS-------------------------------RALYS-LALRCWAPHPADRPS-------FS-HLE----GLL------------
------L-RLLEKLGDGSFGVVRRGEW---D-------------APSGKTV---SVAVKCL---K-PDVLSQ-PEA-MD-DFI-R-------------------------EVNAMHSL--D---HRNLIRLYGVVL-------------TPPMKMVTELAPLGSLLDRLR----KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK--------RFIHRDLAARNLLLA---T-----RDLVKIGDFGLMRAL---PQ--N--DDHY-VMQEHRKVPFAWCAPESLK------TRT----FSHASDTWMFGVTLWEMFTYGQ--------------EP---------------WIGL-----NGSQI-LHKIDKE----GER----LPRPEDCP-------------------------------QDIYN-VMVQCWAHKPEDRPT-------FV-ALRDF--L--------------
-----FI--LTERLGSGTYATVYKAYA---KK---------------DTRE---VVAIKCV---AKK--SLNKAS---V-ENLLT-------------------------EIEILKGI--R---HPHIVQLKDFQW--D----------SDNIYLIMEFCAGGDLSRFIH---TRR----------------------------------------------------------------------------------------------------ILPEKVARVFMQQLASALQFLHER--------NISHLDLKPQNILLSS-LE-----KPHLKLADFGFAQH--------MSPWDEK-HV---LRGSPLYMAPEMVC------QRQ----YDARVDLWSMGVILYEALF-GQ--------------PP---------------FASR-----SFSEL-EEKI-RS----NRV----IELPLRPLLS-----------------------------RDCRD-LLQRLLERDPSRRIS-------FQ-DFFAHPWV--------------
------L-RLEVKLGQGCFGEVWMGTW---N-----------------GTT---KVAIKTL---K-P--GTM-MP---E-AFL-Q-------------------------EAQIMKKL--R---HDKLVPLYAVVS-------------EEPIYIVTEFMSKGSLLDFLK----EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERM--------NYIHRDLRAANILVG---E-----NLVCKIADFGLARLI-------E--DNEY-TARQGAKFPIKWTAPEAAL------YGR----FTIKSDVWSFGILQTELVTKGR--------------VP---------------YPGM-----VNREV-LEQV-ER----GYR----MPCPQGCP-------------------------------ESLHE-LMNLCWKKDPDERPT-------FE-YIQSFL----------------
---LIAD----IELGCGNFGSVRQGVY---R--------------MRKKQI---DVAIKVL---K-Q--GTE-KAD-TE-EMM-R-------------------------EAQIMHQL--D---NPYIVRLIGVCQ-------------AEALMLVMEMAGGGPLHKFLV----GK--------------------------------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEK--------NFVHRDLAARNVLLV---N-----RHYAKISDFGLSKAL---GA--D--DSYY-TARSAGKWPLKWYAPECIN------FRK----FSSRSDVWSYGVTMWEALSYGQ--------------KP---------------YKKM-----KGPEV-MAFI-EQ----GKR----MECPPECP-------------------------------PELYA-LMSDCWIYKWEDRPD-------FL-TVEQR--M--------------
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