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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FGR 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
Other AURKA 133
TK BLK 241
TK BTK 402
TK CSK 195
TK DDR1 572
TK EGFR 712
TK EPHA3 621
TK EPHA5 675
TK EPHA6 631
TK EPHA8 635
TK EPHB1 619
TK EPHB4 615
TK EPHB6 670
TK ERBB2 720
TK ERBB3 709
TK ERBB4 718
TK FGFR1 478
TK FGFR2 481
TK FRK 234
TK HCK 241
TK IGF1R 999
TK JAK2 849
TK JAK3 822
TK KIT 589
TK LCK 245
TK LTK 510
TK LYN 247
STE MAP2K5 166
TK PDGFRA 593
TK PDGFRB 600
AGC PDPK1 82
TK RET 724
STE SLK 34
TK SRC 270
TK SYK 371
TK TNK1 116
TK TNK2 150
TK TXK 271
TK YES1 277
-------ITLERRLGTGCFGDVWLGTWN-----------------GSTKVAVKTL---K-P--G-TM-SP---KA-FL-EEAQVMKLL-RHDKLVQLYAVVS---EEPIYIVTEFMCHGSLLDFLK--NP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGE---RLACKIADFGLARLI-----K--DDEY-NPCQGSKFPIKWTAPEAAL-----FGRFTIKSDVWSFGILLTELITKGR-IP---------------YPGM-NKREVLEQV----EQGYH---MPCPPGCP--------ASLYE-AMEQTWRLDPEERPTFEYLQSFL-------------
-------ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTL---K-E--D-TM-EV---EE-FL-KEAAVMKEI-KHPNLVQLLGVCT--REPPFYIITEFMTYGNLLDYLR--EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKVADFGLSRLM-----T--GDTY-TAHAGAKFPIKWTAPESLA-----YNKFSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQVYELL----EKDYR---MERPEGCP--------EKVYE-LMRACWQWNPSDRPSFAEIHQA--F-----------
-------ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTL---K-E--D-TM-EV---EE-FL-KEAAVMKEI-KHPNLVQLLGVCT--LEPPFYIVTEYMPYGNLLDYLR--EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHVVKVADFGLSRLM-----T--GDTY-TAHAGAKFPIKWTAPESLA-----YNTFSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQVYDLL----EKGYR---MEQPEGCP--------PKVYE-LMRACWKWSPADRPSFAETHQA--F-----------
------I-TLIRGLGHGAFGEVYEGQVSG-----------MPNDPSPLQVAVKTL---P-E--V-CS-EQD-ELD-FL-MEALIISKF-NHQNIVRCIGVSL--QSLPRFILLELMAGGDLKSFLR--ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI---Y-R--ASYY-RKGGCAMLPVKWMPPEAFM-----EGIFTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK-SNQEVLEFV----TSGGR---MDPPKNCP--------GPVYR-IMTQCWQHQPEDRPNFAIILER--I-----------
-------FEIGRPLGKGKFGNVYLAREK----------------QSKFILALKVL---FKA--QLEKAGV---EH-QLRREVEIQSHL-RHPNILRLYGYFH--DATRVYLILEYAPLGTVYRELQ-KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS---AGELKIADFGWSV-------HAPSSRR-TT---LCGTLDYLPPEMIE-----GRMHDEKVDLWSLGVLCYEFLV-GK-PP---------------FEAN----TYQETY----KRISR---VEFTFPDFVT------EGARD-LISRLLKHNPSQRPMLREVLEHPWI-----------
------L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAIKTL---K-E--G-TM-SP---EA-FL-GEANVMKAL-QHERLVRLYAVVT---KEPIYIVTEYMARGCLLDFLK--TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSE---ALCCKIADFGLARII--------DSEY-TAQEGAKFPIKWTAPEAIH-----FGVFTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM-SNPEVIRNL----ERGYR---MPRPDTCP--------PELYRGVIAECWRSRPEERPTFEFLQSV--L-----------
-------LTFLKELGTGQFGVVKYGKWR-----------------GQYDVAIKMI---K-E--G-SM-SE---DE-FI-EEAKVMMNL-SHEKLVQLYGVCT--KQRPIFIITEYMANGCLLNYLR--EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVND---QGVVKVSDFGLSRYV-----L--DDEY-TSSVGSKFPVRWSPPEVLM-----YSKFSSKSDIWAFGVLMWEIYSLGK-MP---------------YERF-TNSETAEHI----AQGLR---LYRPHLAS--------EKVYT-IMYSCWHEKADERPTFKILLSN--I-----------
-------LKLLQTIGKGEFGDVMLGDYR------------------GNKVAVKCI---K-N--D-AT-AQ----A-FL-AEASVMTQL-RHSNLVQLLGVIV-EEKGGLYIVTEYMAKGSLVDYLR--SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSE---DNVAKVSDFGLTKEA-----------S-STQDTGKLPVKWTAPEALR-----EKKFSTKSDVWSFGILLWEIYSFGR-VP---------------YPRI-PLKDVVPRV----EKGYK---MDAPDGCP--------PAVYE-VMKNCWHLDAAMRPSFLQLREQL-------------
-------LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL---R-P--D-AT-KNA-RND-FL-KEVKIMSRL-KDPNIIRLLGVCV--QDDPLCMITDYMENGDLNQFLS--AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGE---NFTIKIADFGMSRNL---Y-A--GDYY-RVQGRAVLPIRWMAWECIL-----MGKFTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL-TDEQVIENAGEFFRDQGRQVYLSRPPACP--------QGLYE-LMLRCWSRESEQRPPFSQLHRFL-------------
------F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKIPVAIKEL---R-E--A-TS-PKA-NKE-IL-DEAYVMASV-DNPHVCRLLGICL---TSTVQLITQLMPFGCLLDYVR--EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL---G-A--EEKE-YHAEGGKVPIKWMALESIL-----HRIYTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI-PASEISSIL----EKGER---LPQPPICT--------IDVYM-IMVKCWMIDADSRPKFRELI----IEF---------
------I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEISVAIKTL---K-V--G-YT-EKQ-RRD-FL-GEASIMGQF-DHPNIIRLEGVVT--KSKPVMIVTEYMENGSLDSFLR--KH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINS---NLVCKVSDFGLSRVL---E-D--DPEAAYTTRGGKIPIRWTSPEAIA-----YRKFTSASDVWSYGIVLWEVMSYGE-RP---------------YWEM-SNQDVIKAV----DEGYR---LPPPMDCP--------AALYQ-LMLDCWQKDRNNRPKFEQIVSIL-------------
-------ITIERVIGAGEFGEVCSGRLK-------------LPGKRELPVAIKTL---K-V--G-YT-EKQ-RRD-FL-GEASIMGQF-DHPNIIHLEGVVT--KSKPVMIVTEYMENGSLDTFLK--KN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINS---NLVCKVSDFGLSRVL---E-D--DPEAAYTTRGGKIPIRWTAPEAIA-----FRKFTSASDVWSYGIVMWEVVSYGE-RP---------------YWEM-TNQDVIKAV----EEGYR---LPSPMDCP--------AALYQ-LMLDCWQKERNSRPKFDEIVNML-------------
LPPRIPA--------------------------------------------------------------------------------------------------GRPVMIVVEYMENGSLDSFLR--KH--------------------------------------------------------------------------------------------------DGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNS---NLVCKVSDFGLSRVL---E-D--DPEAAYTTTGGKIPIRWTAPEAIA-----YRKFSSASDAWSYGIVMWEVMSYGE-RP---------------YWEM-SNQDVILSI----EEGYR---LPAPMGCP--------ASLHQ-LMLHCWQKERNHRPKFTDIVSFL-------------
-------IHIEKIIGSGDSGEVCYGRLR-------------VPGQRDVPVAIKAL---K-A--G-YT-ERQ-RRD-FL-SEASIMGQF-DHPNIIRLEGVVT--RGRLAMIVTEYMENGSLDTFLR--TH--------------------------------------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDS---NLVCKVSDFGLSRVL---E-D--DPDAAYTTTGGKIPIRWTAPEAIA-----FRTFSSASDVWSFGVVMWEVLAYGE-RP---------------YWNM-TNRDVISSV----EEGYR---LPAPMGCP--------HALHQ-LMLDCWHKDRAQRPRFSQIVSVL-------------
------V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREIYVAIKTL---K-A--G-YS-EKQ-RRD-FL-SEASIMGQF-DHPNIIRLEGVVT--KSRPVMIITEFMENGALDSFLR--QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNS---NLVCKVSDFGLSRYLQDDT-S--DPTY-TSSLGGKIPVRWTAPEAIA-----YRKFTSASDVWSYGIVMWEVMSFGE-RP---------------YWDM-SNQDVINAI----EQDYR---LPPPMDCP--------AALHQ-LMLDCWQKDRNSRPRFAEIVNTL-------------
------V-KIEEVIGAGEFGEVCRGRLK-------------APGKKESCVAIKTL---K-G--G-YT-ERQ-RRE-FL-SEASIMGQF-EHPNIIRLEGVVT--NSMPVMILTEFMENGALDSFLR--LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNS---NLVCKVSDFGLSRFLEENS-S--DPTY-TSSLGGKIPIRWTAPEAIA-----FRKFTSASDAWSYGIVMWEVMSFGE-RP---------------YWDM-SNQDVINAI----EQDYR---LPPPPDCP--------TSLHQ-LMLDCWQKDRNARPRFPQVVSAL-------------
-------IKIEEVIGTGSFGEVRQGRLQ-------------PRGRREQTVAIQAL---W-A--G-GA-ESL-QMT-FL-GRAAVLGQF-QHPNILRLEGVVT--KSRPLMVLTEFMELGPLDSFLR--QR--------------------------------------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNS---HLVCKVARLGHSPQG------------------PSCLLRWAAPEVIA-----HGKHTTSSDVWSFGILMWEVMSYGE-RP---------------YWDM-SEQEVLNAI----EQEFR---LPPPPGCP--------PGLHL-LMLDTWQKDRARRPHFDQLVA---AF----------
------L-RKVKVLGSGAFGTVYKGIWIP------------DGENVKIPVAIKVL---R-E--N-TS-PKA-NKE-IL-DEAYVMAGV-GSPYVSRLLGICL---TSTVQLVTQLMPYGCLLDHVR--EN--------------------------------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKS---PNHVKITDFGLARLL---D-I--DETE-YHADGGKVPIKWMALESIL-----RRRFTHQSDVWSYGVTVWELMTFGA-KP---------------YDGI-PAREIPDLL----EKGER---LPQPPICT--------IDVYM-IMVKCWMIDSECRPRFRELVSE--F-----------
------L-RKLKVLGSGVFGTVHKGVWIP------------EGESIKIPVCIKVI---E-D--K-SG-RQS-FQA-VT-DHMLAIGSL-DHAHIVRLLGLCP---GSSLQLVTQYLPLGSLLDHVR--QH--------------------------------------------------------------------------------------------------RGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKS---PSQVQVADFGVADLL---P-P--DDKQ-LLYSEAKTPIKWMALESIH-----FGKYTHQSDVWSYGVTVWELMTFGA-EP---------------YAGL-RLAEVPDLL----EKGER---LAQPQICT--------IDVYM-VMVKCWMIDENIRPTFKELANE--F-----------
------L-KRVKVLGSGAFGTVYKGIWVP------------EGETVKIPVAIKIL---N-E--T-TG-PKA-NVE-FM-DEALIMASM-DHPHLVRLLGVCL---SPTIQLVTQLMPHGCLLEYVH--EH--------------------------------------------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKS---PNHVKITDFGLARLL---E-G--DEKE-YNADGGKMPIKWMALECIH-----YRKFTHQSDVWSYGVTIWELMTFGG-KP---------------YDGI-PTREIPDLL----EKGER---LPQPPICT--------IDVYM-VMVKCWMIDADSRPKFKELAAE--F-----------
------L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKML---K-S--D-AT-EKD-LSD-LI-SEMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLQ--ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI---H-H--IDYY-KKTTNGRLPVKWMAPEALF-----DRIYTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV-PVEELFKLL----KEGHR---MDKPSNCT--------NELYM-MMRDCWHAVPSQRPTFKQLVEDL-------------
-------LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAVKML---K-D--D-AT-EKD-LSD-LV-SEMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLR--ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDI---N-N--IDYY-KKTTNGRLPVKWMAPEALF-----DRVYTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI-PVEELFKLL----KEGHR---MDKPANCT--------NELYM-MMRDCWHAVPSQRPTFKQLVEDL-------------
-------IQLLKRLGSGQFGEVWEGLWN-----------------NTTPVAVKTL---K-P--G-SM-DP---ND-FL-REAQIMKNL-RHPKLIQLYAVCT--LEDPIYIITELMRHGSLQEYLQ--ND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGE---HNIYKVADFGLARVFK-VD-N--EDIY-ESRHEIKLPVKWTAPEAIR-----SNKFSIKSDVWSFGILLYEIITYGK-MP---------------YSGM-TGAQVIQML----AQNYR---LPQPSNCP--------QQFYN-IMLECWNAEPKERPTFETLRWK--L-----------
-------LKLEKKLGAGQFGEVWMATYN-----------------KHTKVAVKTM---K-P--G-SM-SV---EA-FL-AEANVMKTL-QHDKLVKLHAVVT---KEPIYIITEFMAKGSLLDFLK--SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA---SLVCKIADFGLARVI-----E--DNEY-TAREGAKFPIKWTAPEAIN-----FGSFTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM-SNPEVIRAL----ERGYR---MPRPENCP--------EELYN-IMMRCWKNRPEERPTFEYIQSV--L-----------
-------ITMSRELGQGSFGMVYEGVAKG-----------VVKDEPETRVAIKTV---N-E--A-AS-MRE-RIE-FL-NEASVMKEF-NCHHVVRLLGVVS--QGQPTLVIMELMTRGDLKSYLR--SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI---Y-E--TDYY-RKGGKGLLPVRWMSPESLK-----DGVFTTYSDVWSFGVVLWEIATLAE-QP---------------YQGL-SNEQVLRFV----MEGGL---LDKPDNCP--------DMLFE-LMRMCWQYNPKMRPSFLEIISS--I-----------
-------LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAVKKL---Q-H--S-TE--EH-LRD-FE-REIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ--KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN---ENRVKIGDFGLTKVL--PQ-D--KEYY-KVKEPGESPIFWYAPESLT-----ESKFSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM-IVFHLIELL----KNNGR---LPRPDGCP--------DEIYM-IMTECWNNNVNQRPSFRDLA----LRV---------
------L-KYISQLGKGNFGSVELCRYDP------------LGDNTGALVAVKQL---Q-H--S-GP-DQ--QRD-FQ-REIQILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ--RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVES---EAHVKIADFGLAKLL--PL-D--KDYY-VVREPGQSPIFWYAPESLS-----DNIFSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDVPALCRLLELL----EEGQR---LPAPPACP--------AEVHE-LMKLCWAPSPQDRPSFSALGP---QL----------
-------LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAVKML---K-P--S-AH-LTE-REA-LM-SELKVLSYLGNHMNIVNLLGACT--IGGPTLVITEYCCYGDLLNFLR--RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH---GRITKICDFGLARDI---K-N--DSNY-VVKGNARLPVKWMAPESIF-----NCVYTFESDVWSYGIFLWELFSLGS-SP---------------YPGMPVDSKFYKMI----KEGFR---MLSPEHAP--------AEMYD-IMKTCWDADPLKRPTFKQIVQL--I-----------
-------LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSL---K-Q--G-SM-SP---DA-FL-AEANLMKQL-QHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLK--TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI-----E--DNEY-TAREGAKFPIKWTAPEAIN-----YGTFTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM-TNPEVIQNL----ERGYR---MVRPDNCP--------EELYQ-LMRLCWKERPEDRPTFDYLRSV--L-----------
------V-TLLRALGHGAFGEVYEGLVIG-----------LPGDSSPLQVAIKTL---P-E--L-CS-PQD-ELD-FL-MEALIISKF-RHQNIVRCVGLSL--RATPRLILLELMSGGDMKSFLR--HSRP--------------------------------------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDI---Y-R--ASYY-RRGDRALLPVKWMPPEAFL-----EGIFTSKTDSWSFGVLLWEIFSLGY-MP---------------YPGR-TNQEVLDFV----VGGGR---MDPPRGCP--------GPVYR-IMTQCWQHEPELRPSFASILERL-------------
-------IKLVKRLGAGQFGEVWMGYYN-----------------NSTKVAVKTL---K-P--G-TM-SV---QA-FL-EEANLMKTL-QHDKLVRLYAVVT--REEPIYIITEYMAKGSLLDFLK--SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSE---SLMCKIADFGLARVI-----E--DNEY-TAREGAKFPIKWTAPEAIN-----FGCFTIKSDVWSFGILLYEIVTYGK-IP---------------YPGR-TNADVMTAL----SQGYR---MPRVENCP--------DELYD-IMKMCWKEKAEERPTFDYLQSV--L-----------
----IRY---RDTLGHGNGGTVYKAYHV----------------PSGKILAVKVI---LLD--I-TLELQ---KQ-I-MSELEILYKC-DSSYIIGFYGAFF--VENRISICTEFMDGGSLD-----VYR----------------------------------------------------------------------------------------------------KMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNT---RGQVKLCDFGVST-------QLVNSIA-KT---YVGTNAYMAPERIS-----GEQYGIHSDVWSLGISFMELAL-GR-FP---------------YPQI-QKNQGSLMP----LQLLQ---CIVDEDSPVLPVGEFSEPFVH-FITQCMRKQPKERPAPEELMGHPFI-----------
------L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAVKML---K-P--T-AR-SSE-KQA-LM-SELKIMTHLGPHLNIVNLLGACT--KSGPIYIITEYCFYGDLVNYLH--KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQ---GKIVKICDFGLARDI---M-H--DSNY-VSKGSTFLPVKWMAPESIF-----DNLYTTLSDVWSYGILLWEIFSLGG-TP---------------YPGMMVDSTFYNKI----KSGYR---MAKPDHAT--------SEVYE-IMVKCWNSEPEKRPSFYHLSE---IV----------
------L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAVKML---K-S--T-AR-SSE-KQA-LM-SELKIMSHLGPHLNVVNLLGACT--KGGPIYIITEYCRYGDLVDYLH--RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICE---GKLVKICDFGLARDI---M-R--DSNY-ISKGSTFLPLKWMAPESIF-----NSLYTTLSDVWSFGILLWEIFTLGG-TP---------------YPELPMNEQFYNAI----KRGYR---MAQPAHAS--------DEIYE-IMQKCWEEKFEIRPPFSQLVL---LL----------
------F-KFGKILGEGSFSTVVLAREL----------------ATSREYAIKIL---EKR--H-IIKEN---KVPYVTRERDVMSRL-DHPFFVKLYFTFQ--DDEKLYFGLSYAKNGELLKYIR-KIG----------------------------------------------------------------------------------------------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNE---DMHIQITDFGTAKVLS---PESKQARA-NS---FVGTAQYVSPELLT-----EKSACKSSDLWALGCIIYQLVA-GL-PP---------------FRAG----NEYLIF----QKIIK---LEYDFPEKFF------PKARD-LVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
------L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYTTVAVKML---K-E--N-AS-PSE-LRD-LL-SEFNVLKQV-NHPHVIKLYGACS--QDGPLLLIVEYAKYGSLRGFLR--ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV---Y-E--EDSY-VKRSQGRIPVKWMAIESLF-----DHIYTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI-PPERLFNLL----KTGHR---MERPDNCS--------EEMYR-LMLQCWKQEPDKRPVFADISKDL-------------
-------WEIIGELGDGAFGKVYKAQNK----------------ETSVLAAAKVI---DTK--S-EEELE---DY-M--VEIDILASC-DHPNIVKLLDAFY--YENNLWILIEFCAGGAVDAVMLELER----------------------------------------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTL---DGDIKLADFGVSAKN-----TRTIQRR-DS---FIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAE-IE-PP---------------HHEL-NPMRVLLKI----AKSEP---PTLAQPSRWS------SNFKD-FLKKCLEKNVDARWTTSQLLQHPFV-----------
------L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAIKTL---K-P--G-TM-SP---EA-FL-QEAQVMKKL-RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLK--GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI-----E--DNEY-TARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGILLTELTTKGR-VP---------------YPGM-VNREVLDQV----ERGYR---MPCPPECP--------ESLHD-LMCQCWRKEPEERPTFEYLQAF--L-----------
----TLE---DKELGSGNFGTVKKGYYQ--------------MKKVVKTVAVKIL---K-N--E-AN-DPALKDE-LL-AEANVMQQL-DNPYIVRMIGICE---AESWMLVMEMAELGPLNKYLQ--QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT---QHYAKISDFGLSKAL---R-A--DENYYKAQTHGKWPVKWYAPECIN-----YYKFSSKSDVWSFGVLMWEAFSYGQ-KP---------------YRGM-KGSEVTAML----EKGER---MGCPAGCP--------REMYD-LMNLCWTYDVENRPGFAAVE----LRL---------
----VCR---GELLGSGCFGVVHRGLWT-------------LPSGKSVPVAVKSLRVGP-E--G-PM-GTE-LGD-FL-REVSVMMNL-EHPHVLRLHGLVL---GQPLQMVMELAPLGSLHARLT--AP------------------------------------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLAS---PRTIKVADFGLVRPL--GG-A--RGRY-VMGGPRPIPYAWCAPESLR-----HGAFSSASDVWMFGVTLWEMFSGGE-EP---------------WAGV-PPYLILQRL----EDRAR---LPRPPLCS--------RALYS-LALRCWAPHPADRPSFSHLE----GLL---------
------L-RLLEKLGDGSFGVVRRGEWD-------------APSGKTVSVAVKCL---K-PDVL-SQ-PEA-MDD-FI-REVNAMHSL-DHRNLIRLYGVVL---TPPMKMVTELAPLGSLLDRLR--KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLAT---RDLVKIGDFGLMRAL--PQ-N--DDHY-VMQEHRKVPFAWCAPESLK-----TRTFSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL-NGSQILHKI---DKEGER---LPRPEDCP--------QDIYN-VMVQCWAHKPEDRPTFVALRDF--L-----------
------L-AFIKEIGSGQFGVVHLGEWR-----------------SHIQVAIKAI---N-E--G-SM-SE---ED-FI-EEAKVMMKL-SHSKLVQLYGVCI--QRKPLYIVTEFMENGCLLNYLR--EN--------------------------------------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSS---TCIVKISDFGMTRYV-----L--DDEY-VSSFGAKFPIKWSPPEVFL-----FNKYSSKSDVWSFGVLMWEVFTEGK-MP---------------FENK-SNLQVVEAI----SEGFR---LYRPHLAP--------MSIYE-VMYSCWHEKPEGRPTFAELLR---AV----------
------L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAIKTL---K-P--G-TM-MP---EA-FL-QEAQIMKKL-RHDKLVPLYAVVS---EEPIYIVTEFMSKGSLLDFLK--EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGE---NLVCKIADFGLARLI-----E--DNEY-TARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGILQTELVTKGR-VP---------------YPGM-VNREVLEQV----ERGYR---MPCPQGCP--------ESLHE-LMNLCWKKDPDERPTFEYIQSFL-------------
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