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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FGR 203
TK ABL1 261
TK ABL2 288
AGC AKT3 148
TK ALK 1116
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK BLK 241
TK BMX 422
TK BTK 402
Other CAMKK2 165
CMGC CDC2 4
CMGC CDC2L5 705
CMGC CDK2 4
CMGC CDKL1 5
CMGC CDKL2 4
CMGC CDKL3 4
TK CSF1R 582
TK CSK 195
TK DDR1 572
TK EGFR 712
TK EPHA8 635
TK ERBB2 720
TK ERBB4 718
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FYN 271
AGC GRK1 190
AGC GRK4 187
AGC GRK5 186
AGC GRK6 186
CMGC GSK3A 119
CMGC GSK3B 56
TK HCK 241
CMGC ICK 4
TK INSR 1023
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
CAMK KIAA0999 66
TK KIT 589
TK LTK 510
STE MAP2K1 68
TKL MAP3K7 36
CAMK MARK2 53
CAMK MARK4 59
TK MATK 235
TK MET 1078
STE MST4 24
TK MUSK 575
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
CAMK NUAK2 97
TK PDGFRA 593
TK PDGFRB 600
AGC PDPK1 82
AGC PKN1 615
AGC PKN2 657
AGC PRKCA 339
AGC PRKCB 342
AGC PRKCH 355
AGC PRKCQ 380
TK PTK6 191
TKL RAF1 349
TK RET 724
TKL RIPK2 18
TKL RIPK4 22
TK ROS1 1945
AGC RPS6KB1 91
CAMK SIK1 27
CAMK SIK2 20
STE SLK 34
TK SRC 270
TK SRMS 230
STE STK10 36
CAMK STK17A 61
STE STK24 24
STE STK25 20
TK SYK 371
TK TEC 370
TK TEK 824
TK TIE1 839
TK TNK1 116
TK TNK2 150
TKL TNNI3K 463
TK TXK 271
TK YES1 277
TK ZAP70 338
----ITLERRLGTGCFGDVWLGTW---N-----------------GSTKVAVKTL---K-P--G-TM-SP---KA-FL-E-------------------------EAQVMKLL--R---HDKLVQLYAVVS-------------EEP--IY--IVTEFMCHG--SLLDFLK-----NP-------------------------------------------------------------------------------------------------EG-QDL---RLPQLVDMAAQVAEGMAYMER--M--N---YIHRDLRAANILVG-E-----RL-AC---KIADFGLARLI-------K--DDEY--------------NPCQGSKFPIKWTAPEAAL-----FGR----FTIKSDVWSFGILLTELITKGR-IP---------------YPGM---NKREVLEQV----EQGYH----MPCPPGCP-------------------------------------------ASLYE-AMEQTWRLDPEERPT------FE-YLQSFL----------------
----ITMKHKLGGGQYGEVYEGVW---K----------------KYSLTVAVKTL---K-E--D-TM-EV---EE-FL-K-------------------------EAAVMKEI--K---HPNLVQLLGVCT--R----------EPP--FY--IITEFMTYG--NLLDYLR-----EC-------------------------------------------------------------------------------------------------NR-QEV---NAVVLLYMATQISSAMEYLEK--K--N---FIHRDLAARNCLVG-E-----NH-LV---KVADFGLSRLM-------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNK----FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI---DLSQVYELL----EKDYR----MERPEGCP-------------------------------------------EKVYE-LMRACWQWNPSDRPS------FA-EIHQA--F--------------
----ITMKHKLGGGQYGEVYVGVW---K----------------KYSLTVAVKTL---K-E--D-TM-EV---EE-FL-K-------------------------EAAVMKEI--K---HPNLVQLLGVCT--L----------EPP--FY--IVTEYMPYG--NLLDYLR-----EC-------------------------------------------------------------------------------------------------NR-EEV---TAVVLLYMATQISSAMEYLEK--K--N---FIHRDLAARNCLVG-E-----NH-VV---KVADFGLSRLM-------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNT----FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI---DLSQVYDLL----EKGYR----MEQPEGCP-------------------------------------------PKVYE-LMRACWKWSPADRPS------FA-ETHQA--F--------------
--FD--YLKLLGKGTFGKVILVRE---K----------------ASGKYYAMKIL---KKE--V-IIAKD---EV-AHTL------------------------TESRVLKNT--R---HPFLTSLKYSFQ--T----------KDR--LC--FVMEYVNGG--ELFFHLS----RER-----------------------------------------------------------------------------------------------------VF---SEDRTRFYGAEIVSALDYLHS--G--K---IVYRDLKLENLMLD-K-----DG-HI---KITDFGLCKEG-------ITDAATM--------------KT---FCGTPEYLAPEVLE-----DND----YGRAVDWWGLGVVMYEMMC-GR-LP---------------FYNQ------DHEKLF----ELILM----EDIKFPRTLS-----------------------------------------SDAKS-LLSGLLIKDPNKRLGGG-PDDAK-EIMRHSFF--------------
---I-TLIRGLGHGAFGEVYEGQV---SG-----------MPNDPSPLQVAVKTL---P-E--V-CS-EQD-ELD-FL-M-------------------------EALIISKF--N---HQNIVRCIGVSL--Q----------SLP--RF--ILLELMAGG--DLKSFLR-----ETRP--------------------------------------------------------------------------------------------RPSQP-SSL---AMLDLLHVARDIACGCQYLEE--N--H---FIHRDIAARNCLLT-CP--GPGR-VA---KIGDFGMARDI---Y---R--ASYY--------------RKGGCAMLPVKWMPPEAFM-----EGI----FTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK---SNQEVLEFV----TSGGR----MDPPKNCP-------------------------------------------GPVYR-IMTQCWQHQPEDRPN------FA-IILER--I--------------
----FEIGRPLGKGKFGNVYLARE---K----------------QSKFILALKVL---FKA--QLEKAGV---EH-QLRR-------------------------EVEIQSHL--R---HPNILRLYGYFH--D----------ATR--VY--LILEYAPLG--TVYRELQ----KLS-----------------------------------------------------------------------------------------------------KF---DEQRTATYITELANALSYCHS--K--R---VIHRDIKPENLLLG-S-----AG-EL---KIADFGWSV---------HAPSSRR--------------TT---LCGTLDYLPPEMIE-----GRM----HDEKVDLWSLGVLCYEFLV-GK-PP---------------FEAN------TYQETY----KRISR----VEFTFPDFVT-----------------------------------------EGARD-LISRLLKHNPSQRPM------LR-EVLEHPWI--------------
----FEIGRPLGKGKFGNVYLARE---K----------------KSHFIVALKVL---FKS--Q-IEKEG---VE-HQLR------------------------REIEIQAHL--H---HPNILRLYNYFY--D----------RRR--IY--LILEYAPRG--ELYKELQ----KSC-----------------------------------------------------------------------------------------------------TF---DEQRTATIMEELADALMYCHG--K--K---VIHRDIKPENLLLG-L-----KG-EL---KIADFGWSV---------HAPSLRR--------------KT---MCGTLDYLPPEMIE-----GRM----HNEKVDLWCIGVLCYELLV-GN-PP---------------FESA------SHNETY----RRIVK----VDLKFPASVP-----------------------------------------MGAQD-LISKLLRHNPSERLP------LA-QVSAHPWV--------------
----FEIGRPLGKGKFGNVYLARL---K----------------ESHFIVALKVL---FKS--Q-IEKEG---LE-HQLR------------------------REIEIQAHL--Q---HPNILRLYNYFH--D----------ARR--VY--LILEYAPRG--ELYKELQ----KSE-----------------------------------------------------------------------------------------------------KL---DEQRTATIIEELADALTYCHD--K--K---VIHRDIKPENLLLG-F-----RG-EV---KIADFGWSV---------HTPSLRR--------------KT---MCGTLDYLPPEMIE-----GRT----YDEKVDLWCIGVLCYELLV-GY-PP---------------FESA------SHSETY----RRILK----VDVRFPLSMP-----------------------------------------LGARD-LISRLLRYQPLERLP------LA-QILKHPWV--------------
---L-RLVRKLGSGQFGEVWMGYY---K-----------------NNMKVAIKTL---K-E--G-TM-SP---EA-FL-G-------------------------EANVMKAL--Q---HERLVRLYAVVT-------------KEP--IY--IVTEYMARG--CLLDFLK-----TD-------------------------------------------------------------------------------------------------EG-SRL---SLPRLIDMSAQIAEGMAYIER--M--N---SIHRDLRAANILVS-E-----AL-CC---KIADFGLARII----------DSEY--------------TAQEGAKFPIKWTAPEAIH-----FGV----FTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM---SNPEVIRNL----ERGYR----MPRPDTCP-------------------------------------------PELYRGVIAECWRSRPEERPT------FE-FLQSV--L--------------
----ITLLKELGSGQFGVVQLGKW---K-----------------GQYDVAVKMI---K-E--G-SM-SE---DE-FF-Q-------------------------EAQTMMKL--S---HPKLVKFYGVCS--K----------EYP--IY--IVTEYISNG--CLLNYLR-----SH--------------------------------------------------------------------------------------------------G-KGL---EPSQLLEMCYDVCEGMAFLES--H--Q---FIHRDLAARNCLVD-R-----DL-CV---KVSDFGMTRYV-------L--DDQY--------------VSSVGTKFPVKWSAPEVFH-----YFK----YSSKSDVWAFGILMWEVFSLGK-QP---------------YDLY---DNSQVVLKV----SQGHR----LYRPHLAS-------------------------------------------DTIYQ-IMYSCWHELPEKRPT------FQ-QLLSS--I--------------
----LTFLKELGTGQFGVVKYGKW---R-----------------GQYDVAIKMI---K-E--G-SM-SE---DE-FI-E-------------------------EAKVMMNL--S---HEKLVQLYGVCT--K----------QRP--IF--IITEYMANG--CLLNYLR-----EM--------------------------------------------------------------------------------------------------R-HRF---QTQQLLEMCKDVCEAMEYLES--K--Q---FLHRDLAARNCLVN-D-----QG-VV---KVSDFGLSRYV-------L--DDEY--------------TSSVGSKFPVRWSPPEVLM-----YSK----FSSKSDIWAFGVLMWEIYSLGK-MP---------------YERF---TNSETAEHI----AQGLR----LYRPHLAS-------------------------------------------EKVYT-IMYSCWHEKADERPT------FK-ILLSN--I--------------
----YTLKDEIGKGSYGVVKLAYN---E----------------NDNTYYAMKVL---SKK--K-LIRQA---GF-PR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL--D---HPNVVKLVEVLD--DP--------NEDH--LY--MVFELVNQG--PVMEVPT-----LK-----------------------------------------------------------------------------------------------------PL---SEDQARFYFQDLIKGIEYLHY--Q--K---IIHRDIKPSNLLVG-E-----DG-HI---KIADFGVSNEF-------KGSDALL--------------SN---TVGTPAFMAPESLS----ETRKIF--SGKALDVWAMGVTLYCFVF-GQ-CP---------------FMDE------RIMCLH----SKIKS----QALEFPDQPDIA---------------------------------------EDLKD-LITRMLDKNPESRIV------VP-EIKLHPWV--------------
----YTKIEKIGEGTYGVVYKGRH---K----------------TTGQVVAMKKI---RLE--S-EEEGV---PS-TAIR-------------------------EISLLKEL--R---HPNIVSLQDVLM--Q----------DSR--LY--LIFEFLSM---DLKKYLDS-IPPGQ-----------------------------------------------------------------------------------------------------YM---DSSLVKSYLYQILQGIVFCHS--R--R---VLHRDLKPQNLLID-D-----KG-TI---KLADFGLARAF-------GIPIRVY--------------TH---EVVTLWYRSPEVLL----GSAR----YSTPVDIWSIGTIFAELAT-KK-PL---------------FHGD---SEIDQLFRI----FRALG----TPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS------GK-MALNHPYF--------------
---F-DIIGIIGEGTYGQVYKARD---K----------------DTGEMVALKKV---RLD--N-EKEGF---PI-TAIR-------------------------EIKILRQL--T---HQSIINMKEIVT--DKEDALDFKKDKGA--FY--LVFEYMDH---DLMGLLE---SGLV-----------------------------------------------------------------------------------------------------HF---NENHIKSFMRQLMEGLDYCHK--K--N---FLHRDIKCSNILLN-N-----RG-QI---KLADFGLARLY------SSEESRPY--------------TN---KVITLWYRPPELLL----GEER----YTPAIDVWSCGCILGELFT-KK-PI---------------FQAN---QELAQLELI----SRICG----SPCPAVWPDVIKLPYFNTMKPKKQY--------------RRKLREEFVFIPAAALD-LFDYMLALDPSKRCT------AE-QALQCEF-L-------------
----FQKVEKIGEGTYGVVYKARN---K----------------LTGEVVALKKI---RLD--T-ETEGV---PS-TAIR-------------------------EISLLKEL--N---HPNIVKLLDVIH--T----------ENK--LY--LVFEFLHQ---DLKKFMDA--SALT-----------------------------------------------------------------------------------------------------GI---PLPLIKSYLFQLLQGLAFCHS--H--R---VLHRDLKPQNLLIN-T-----EG-AI---KLADFGLARAF-------GVPVRTY--------------TH---EVVTLWYRAPEILL----GCKY----YSTAVDIWSLGCIFAEMVT-RR-AL---------------FPGD---SEIDQLFRI----FRTLG----TPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS------AK-AALAHPFF--------------
----YEKIGKIGEGSYGVVFKCRN---R----------------DTGQIVAIKKF---LES--E-DDPVI---KK-IALR-------------------------EIRMLKQL--K---HPNLVNLLEVFR--R----------KRR--LH--LVFEYCDHT--VLHELDR----YQR-----------------------------------------------------------------------------------------------------GV---PEHLVKSITWQTLQAVNFCHK--H--N---CIHRDVKPENILIT-K-----HS-VI---KLCDFGFARLL-------AGPSDYY--------------TD---YVATRWYRSPELLV----GDTQ----YGPPVDVWAIGCVFAELLS-GV-PL---------------WPGK---SDVDQLYLI----RKTLG----DLIPRHQQVFSTNQYFSGVKIPDPED-------------MEPLELKFPNISYPALG-LLKGCLHMDPTQRLT------CE-QLLHHPYF--------------
----YENLGLVGEGSYGMVMKCRN---K----------------DTGRIVAIKKF---LES--D-DDKMV---KK-IAMR-------------------------EIKLLKQL--R---HENLVNLLEVCK--K----------KKR--WY--LVFEFVDHT--ILDDLEL----FPN-----------------------------------------------------------------------------------------------------GL---DYQVVQKYLFQIINGIGFCHS--H--N---IIHRDIKPENILVS-Q-----SG-VV---KLCDFGFARTL-------AAPGEVY--------------TD---YVATRWYRAPELLV----GDVK----YGKAVDVWAIGCLVTEMFM-GE-PL---------------FPGD---SDIDQLYHI----MMCLG----NLIPRHQELFNKNPVFAGVRLPEIKE-------------REPLERRYPKLSEVVID-LAKKCLHIDPDKRPF------CA-ELLHHDFF--------------
----YETLGKVGEGSYGTVMKCKH---K----------------NTGQIVAIKIF---YER--P-EQSVN---K--IAMR-------------------------EIKFLKQF--H---HENLVNLIEVFR--Q----------KKK--IH--LVFEFIDHT--VLDELQH----YCH-----------------------------------------------------------------------------------------------------GL---ESKRLRKYLFQILRAIDYLHS--N--N---IIHRDIKPENILVS-Q-----SG-IT---KLCDFGFARTL-------AAPGDIY--------------TD---YVATRWYRAPELVL----KDTS----YGKPVDIWALGCMIIEMAT-GN-PY---------------LPSS---SDLDLLHKI----VLKVG----N-LSPHLQNIFSKSPIFAGVVLPQVQ------------HPKNARKKYPKLNGLLAD-IVHACLQIDPADRIS------SS-DLLHHEYF--------------
----LQFGKTLGAGAFGKVVEATA---FG-----------LGKEDAVLKVAVKML---K-S--T-AH-ADE-KEA-LM-S-------------------------ELKIMSHLG-Q---HENIVNLLGACT--H----------GGP--VL--VITEYCCYG--DLLNFLR-----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDG-RPL---ELRDLLHFSSQVAQGMAFLAS--K--N---CIHRDVAARNVLLT-N-----GH-VA---KIGDFGLARDI---M---N--DSNY--------------IVKGNARLPVKWMAPESIF-----DCV----YTVQSDVWSYGILLWEIFSLGL-NP---------------YPGI-L-VNSKFYKLV----KDGYQ----MAQPAFAP-------------------------------------------KNIYS-IMQACWALEPTHRPT------FQ-QICSFL----------------
----LKLLQTIGKGEFGDVMLGDY---R------------------GNKVAVKCI---K-N--D-AT-AQ----A-FL-A-------------------------EASVMTQL--R---HSNLVQLLGVIV-EE----------KGG--LY--IVTEYMAKG--SLVDYLR-----SR-------------------------------------------------------------------------------------------------GR-SVL---GGDCLLKFSLDVCEAMEYLEG--N--N---FVHRDLAARNVLVS-E-----DN-VA---KVSDFGLTKEA-------------S--------------STQDTGKLPVKWTAPEALR-----EKK----FSTKSDVWSFGILLWEIYSFGR-VP---------------YPRI---PLKDVVPRV----EKGYK----MDAPDGCP-------------------------------------------PAVYE-VMKNCWHLDAAMRPS------FL-QLREQL----------------
----LRFKEKLGEGQFGEVHLCEV---DSPQDLVSLDFPLNVRKGHPLLVAVKIL---R-P--D-AT-KNA-RND-FL-K-------------------------EVKIMSRL--K---DPNIIRLLGVCV--Q----------DDP--LC--MITDYMENG--DLNQFLS-----AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQG-PTI---SYPMLLHVAAQIASGMRYLAT--L--N---FVHRDLATRNCLVG-E-----NF-TI---KIADFGMSRNL---Y---A--GDYY--------------RVQGRAVLPIRWMAWECIL-----MGK----FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL---TDEQVIENAGEFFRDQGRQ-VYLSRPPACP-------------------------------------------QGLYE-LMLRCWSRESEQRPP------FS-QLHRFL----------------
---F-KKIKVLGSGAFGTVYKGLW---IP------------EGEKVKIPVAIKEL---R-E--A-TS-PKA-NKE-IL-D-------------------------EAYVMASV--D---NPHVCRLLGICL-------------TST--VQ--LITQLMPFG--CLLDYVR-----EH--------------------------------------------------------------------------------------------------K-DNI---GSQYLLNWCVQIAKGMNYLED--R--R---LVHRDLAARNVLVK-T-----PQ-HV---KITDFGLAKLL---G---A--EEKE--------------YHAEGGKVPIKWMALESIL-----HRI----YTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI---PASEISSIL----EKGER----LPQPPICT-------------------------------------------IDVYM-IMVKCWMIDADSRPK------FR-ELI----IEF------------
----IHIEKIIGSGDSGEVCYGRL---R-------------VPGQRDVPVAIKAL---K-A--G-YT-ERQ-RRD-FL-S-------------------------EASIMGQF--D---HPNIIRLEGVVT--R----------GRL--AM--IVTEYMENG--SLDTFLR-----TH--------------------------------------------------------------------------------------------------D-GQF---TIMQLVGMLRGVGAGMRYLSD--L--G---YVHRDLAARNVLVD-S-----NL-VC---KVSDFGLSRVL---E---D--DPDA-------------AYTTTGGKIPIRWTAPEAIA-----FRT----FSSASDVWSFGVVMWEVLAYGE-RP---------------YWNM---TNRDVISSV----EEGYR----LPAPMGCP-------------------------------------------HALHQ-LMLDCWHKDRAQRPR------FS-QIVSVL----------------
---L-RKVKVLGSGAFGTVYKGIW---IP------------DGENVKIPVAIKVL---R-E--N-TS-PKA-NKE-IL-D-------------------------EAYVMAGV--G---SPYVSRLLGICL-------------TST--VQ--LVTQLMPYG--CLLDHVR-----EN--------------------------------------------------------------------------------------------------R-GRL---GSQDLLNWCMQIAKGMSYLED--V--R---LVHRDLAARNVLVK-S-----PN-HV---KITDFGLARLL---D---I--DETE--------------YHADGGKVPIKWMALESIL-----RRR----FTHQSDVWSYGVTVWELMTFGA-KP---------------YDGI---PAREIPDLL----EKGER----LPQPPICT-------------------------------------------IDVYM-IMVKCWMIDSECRPR------FR-ELVSE--F--------------
---L-KRVKVLGSGAFGTVYKGIW---VP------------EGETVKIPVAIKIL---N-E--T-TG-PKA-NVE-FM-D-------------------------EALIMASM--D---HPHLVRLLGVCL-------------SPT--IQ--LVTQLMPHG--CLLEYVH-----EH--------------------------------------------------------------------------------------------------K-DNI---GSQLLLNWCVQIAKGMMYLEE--R--R---LVHRDLAARNVLVK-S-----PN-HV---KITDFGLARLL---E---G--DEKE--------------YNADGGKMPIKWMALECIH-----YRK----FTHQSDVWSYGVTIWELMTFGG-KP---------------YDGI---PTREIPDLL----EKGER----LPQPPICT-------------------------------------------IDVYM-VMVKCWMIDADSRPK------FK-ELAAE--F--------------
--VI--LGELLGKGNFGEVYKGTL---K-----------------DKTSVAVKTC---K-E--D-LP-QEL-KIK-FL-Q-------------------------EAKILKQY--D---HPNIVKLIGVCT--Q----------RQP--VY--IIMELVSGG--DFLTFLR-----RK--------------------------------------------------------------------------------------------------K-DEL---KLKQLVKFSLDAAAGMLYLES--K--N---CIHRDLAARNCLVG-E-----NN-VL---KISDFGMSRQE-------D--GGVY--------------SSSGLKQIPIKWTAPEALN-----YGR----YSSESDVWSFGILLWETFSLGV-CP---------------YPGM---TNQQAREQV----ERGYR----MSAPQHCP-------------------------------------------EDISK-IMMKCWDYKPENRPK------FS-ELQKEL----------------
---L-VLGEQIGRGNFGEVFSGRL---R----------------ADNTLVAVKSC---R-E--T-LP-PDL-KAK-FL-Q-------------------------EARILKQY--S---HPNIVRLIGVCT--Q----------KQP--IY--IVMELVQGG--DFLTFLR-----TE--------------------------------------------------------------------------------------------------G-ARL---RVKTLLQMVGDAAAGMEYLES--K--C---CIHRDLAARNCLVT-E-----KN-VL---KISDFGMSREE---A---D--GVYA--------------ASGGLRQVPVKWTAPEALN-----YGR----YSSESDVWSFGILLWETFSLGA-SP---------------YPNL---SNQQTREFV----EKGGR----LPCPELCP-------------------------------------------DAVFR-LMEQCWAYEPGQRPS------FS-TIYQEL----------------
---L-VLGKPLGEGCFGQVVLAEA---IGL---------DKDKPNRVTKVAVKML---K-S--D-AT-EKD-LSD-LI-S-------------------------EMEMMKMIG-K---HKNIINLLGACT--Q----------DGP--LY--VIVEYASKG--NLREYLQ-----ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPE-EQL---SSKDLVSCAYQVARGMEYLAS--K--K---CIHRDLAARNVLVT-E-----DN-VM---KIADFGLARDI---H---H--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRI----YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV---PVEELFKLL----KEGHR----MDKPSNCT-------------------------------------------NELYM-MMRDCWHAVPSQRPT------FK-QLVEDL----------------
----LTLGKPLGEGCFGQVVMAEA---VGI---------DKDKPKEAVTVAVKML---K-D--D-AT-EKD-LSD-LV-S-------------------------EMEMMKMIG-K---HKNIINLLGACT--Q----------DGP--LY--VIVEYASKG--NLREYLR-----ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPE-EQM---TFKDLVSCTYQLARGMEYLAS--Q--K---CIHRDLAARNVLVT-E-----NN-VM---KIADFGLARDI---N---N--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRV----YTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI---PVEELFKLL----KEGHR----MDKPANCT-------------------------------------------NELYM-MMRDCWHAVPSQRPT------FK-QLVEDL----------------
----LTLGKPLGEGCFGQVVMAEA---IGI---------DKDRAAKPVTVAVKML---K-D--D-AT-DKD-LSD-LV-S-------------------------EMEMMKMIG-K---HKNIINLLGACT--Q----------GGP--LY--VLVEYAAKG--NLREFLR-----ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPE-EQL---TFKDLVSCAYQVARGMEYLAS--Q--K---CIHRDLAARNVLVT-E-----DN-VM---KIADFGLARDV---H---N--LDYY--------------KKTTNGRLPVKWMAPEALF-----DRV----YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI---PVEELFKLL----KEGHR----MDKPANCT-------------------------------------------HDLYM-IMRECWHAAPSQRPT------FK-QLVEDL----------------
---L-VLGKPLGEGCFGQVVRAEA---FGM---------DPARPDQASTVAVKML---K-D--N-AS-DKD-LAD-LV-S-------------------------EMEVMKLIG-R---HKNIINLLGVCT--Q----------EGP--LY--VIVECAAKG--NLREFLR-----ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSE-GPL---SFPVLVSCAYQVARGMQYLES--R--K---CIHRDLAARNVLVT-E-----DN-VM---KIADFGLARGV---H---H--IDYY--------------KKTSNGRLPVKWMAPEALF-----DRV----YTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI---PVEELFSLL----REGHR----MDRPPHCP-------------------------------------------PELYG-LMRECWHAAPSQRPT------FK-QLVEAL----------------
----LQLIKRLGNGQFGEVWMGTW---N-----------------GNTKVAIKTL---K-P--G-TM-SP---ES-FL-E-------------------------EAQIMKKL--K---HDKLVQLYAVVS-------------EEP--IY--IVTEYMNKG--SLLDFLK-----DG-------------------------------------------------------------------------------------------------EG-RAL---KLPNLVDMAAQVAAGMAYIER--M--N---YIHRDLRSANILVG-N-----GL-IC---KIADFGLARLI-------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR----FTIKSDVWSFGILLTELVTKGR-VP---------------YPGM---NNREVLEQV----ERGYR----MPCPQDCP-------------------------------------------ISLHE-LMIHCWKKDPEERPT------FE-YLQSFL----------------
FLDF----RVLGKGGFGEVSACQM---K----------------ATGKLYACKKL---NKK--R-LKKRK---GY-QGAM------------------------VEKKILMKV--H---SRFIVSLAYAFE--T----------KAD--LC--LVMTIMNGG--DIRYHIYNVNEENP-----------------------------------------------------------------------------------------------------GF---PEPRALFYTAQIICGLEHLHQ--R--R---IVYRDLKPENVLLD-N-----DG-NV---RISDLGLAVEL-------LDGQSKT--------------KG---YAGTPGFMAPELLQ-----GEE----YDFSVDYFALGVTLYEMIA-AR-GP---------------FRAR--GEKVENKELK----HRIIS----EPVKYPDKFS-----------------------------------------QASKD-FCEALLEKDPEKRLG------FR-D-------ETCDKLRAHPLF--
--FR--HYRVLGKGGFGEVCACQV---R----------------ATGKMYACKKL---QKK--R-IKKRK---GE-AMAL------------------------NEKRILEKV--Q---SRFVVSLAYAYE--T----------KDA--LC--LVLTIMNGG--DLKFHIYN--LGNP-----------------------------------------------------------------------------------------------------GF---DEQRAVFYAAELCCGLEDLQR--E--R---IVYRDLKPENILLD-D-----RG-HI---RISDLGLATE--------IPEGQRV--------------RG---RVGTVGYMAPEVVN-----NEK----YTFSPDWWGLGCLIYEMIQ-GH-SP---------------FKKY---KEKVKWEEV----DQRIK----NDTEEYSE---KFS-------------------------------------EDAKS-ICRMLLTKNPSKRLGCR-GEGAA-GVKQHPV-F-------------
---F-RQYRVLGKGGFGEVCACQV---R----------------ATGKMYACKRL---EKK--R-IKKRK---GE-SMAL------------------------NEKQILEKV--N---SQFVVNLAYAYE--T----------KDA--LC--LVLTIMNGG--DLKFHIYN--MGNP-----------------------------------------------------------------------------------------------------GF---EEERALFYAAEILCGLEDLHR--E--N---TVYRDLKPENILLD-D-----YG-HI---RISDLGLAVK--------IPEGDLI--------------RG---RVGTVGYMAPEVLN-----NQR----YGLSPDYWGLGCLIYEMIE-GQ-SP---------------FRGR------KEKVKR----EEVDR----RVLETEEVYSHKFS-------------------------------------EEAKS-ICKMLLTKDAKQRLGCQ-EEGAA-EVKRHPFF--------------
---F-RQYRVLGKGGFGEVCACQV---R----------------ATGKMYACKKL---EKK--R-IKKRK---GE-AMAL------------------------NEKQILEKV--N---SRFVVSLAYAYE--T----------KDA--LC--LVLTLMNGG--DLKFHIYH--MGQA-----------------------------------------------------------------------------------------------------GF---PEARAVFYAAEICCGLEDLHR--E--R---IVYRDLKPENILLD-D-----HG-HI---RISDLGLAVH--------VPEGQTI--------------KG---RVGTVGYMAPEVVK-----NER----YTFSPDWWALGCLLYEMIA-GQ-SP---------------FQQR---KKKIKREEV----ERLVK-----EVPEEYSER--FS-------------------------------------PQARS-LCSQLLCKDPAERLGCR-GGSAR-EVKEHPLF--------------
----YTDIKVIGNGSFGVVYQARL---A----------------ETRELVAIKKV---LQD--K-RFKNR-----------------------------------ELQIMRKL--D---HCNIVRLRYFFY--SSG------EKKDE--LYLNLVLEYVPETVYRVARHFT---KAKL-----------------------------------------------------------------------------------------------------TI---PILYVKVYMYQLFRSLAYIHS--Q--G---VCHRDIKPQNLLVDPD-----TA-VL---KLCDFGSAKQ--------LVRGEPN--------------VS---YICSRYYRAPELIF----GATD----YTSSIDVWSAGCVLAELLL-GQ-PI---------------FPGD---SGVDQLVEI----IKVLG----TPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFKSRTPPEAIA-LCSSLLEYTPSSRLS------PL-EACAHSFF--------------
----YTDTKVIGNGSFGVVYQAKL---C----------------DSGELVAIKKV---LQD--K-RFKNR-----------------------------------ELQIMRKL--D---HCNIVRLRYFFY--SSG------EKKDE--VYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------------------------------------------------------------------------------------------TL---PVIYVKLYMYQLFRSLAYIHS--F--G---ICHRDIKPQNLLLDPD-----TA-VL---KLCDFGSAKQ--------LVRGEPN--------------VS---YICSRYYRAPELIF----GATD----YTSSIDVWSAGCVLAELLL-GQ-PI---------------FPGD---SGVDQLVEI----IKVLG----TPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFRPRTPPEAIA-LCSRLLEYTPTARLT------PL-EACAHSFF--------------
----LKLEKKLGAGQFGEVWMATY---N-----------------KHTKVAVKTM---K-P--G-SM-SV---EA-FL-A-------------------------EANVMKTL--Q---HDKLVKLHAVVT-------------KEP--IY--IITEFMAKG--SLLDFLK-----SD-------------------------------------------------------------------------------------------------EG-SKQ---PLPKLIDFSAQIAEGMAFIEQ--R--N---YIHRDLRAANILVS-A-----SL-VC---KIADFGLARVI-------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----FGS----FTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM---SNPEVIRAL----ERGYR----MPRPENCP-------------------------------------------EELYN-IMMRCWKNRPEERPT------FE-YIQSV--L--------------
----YTTIRQLGDGTYGSVLLGRS---I----------------ESGELIAIKKM---KRK--F-YSWEE---C--MNLR-------------------------EVKSLKKL--N---HANVVKLKEVIR--E----------NDH--LY--FIFEYMKE---NLYQLIK---ERNK-----------------------------------------------------------------------------------------------------LF---PESAIRNIMYQILQGLAFIHK--H--G---FFHRDLKPENLLCM-G-----PE-LV---KIADFGLARE--------IRSKPPY--------------TD---YVSTRWYRAPEVLL----RSTN----YSSPIDVWAVGCIMAEVYT-LR-PL---------------FPGA---SEIDTIFKI----CQVLG----TPKKTDWPEGYQLSSAMNFRWPQCV--------------PNNLKTLIPNASSEAVQ-LLRDMLQWDPKKRPT------AS-QALRYPYF--------------
----ITLLRELGQGSFGMVYEGNA---RD-----------IIKGEAETRVAVKTV---N-E--S-AS-LRE-RIE-FL-N-------------------------EASVMKGF--T---CHHVVRLLGVVS--K----------GQP--TL--VVMELMAHG--DLKSYLR-----SLRPEA-----------------------------------------------------------------------------------------ENNPGR-PPP---TLQEMIQMAAEIADGMAYLNA--K--K---FVHRDLAARNCMVA-H-----DF-TV---KIGDFGMTRDI---Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGV----FTTSSDMWSFGVVLWEITSLAE-QP---------------YQGL---SNEQVLKFV----MDGGY----LDQPDNCP-------------------------------------------ERVTD-LMRMCWQFNPKMRPT------FL-EIVNLL----------------
----LTFVQEIGSGQFGLVHLGYW---L-----------------NKDKVAIKTI---R-E--G-AM-SE---ED-FI-E-------------------------EAEVMMKL--S---HPKLVQLYGVCL--E----------QAP--IC--LVFEFMEHG--CLSDYLR-----TQ--------------------------------------------------------------------------------------------------R-GLF---AAETLLGMCLDVCEGMAYLEE--A--C---VIHRDLAARNCLVG-E-----NQ-VI---KVSDFGMTRFV-------L--DDQY--------------TSSTGTKFPVKWASPEVFS-----FSR----YSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR---SNSEVVEDI----STGFR----LYKPRLAS-------------------------------------------THVYQ-IMNHCWKERPEDRPA------FS-RLLRQL----------------
---L-KRIRDLGEGHFGKVELCRY---DP------------EGDNTGEQVAVKSL---K-P--E-SG-GNH-IAD-LK-K-------------------------EIEILRNL--Y---HENIVKYKGICT-ED-----------GGNGIK--LIMEFLPSG--SLKEYLP-----KN--------------------------------------------------------------------------------------------------K-NKI---NLKQQLKYAVQICKGMDYLGS--R--Q---YVHRDLAARNVLVE-S-----EH-QV---KIGDFGLTKAI--ET---D--KEYY--------------TVKDDRDSPVFWYAPECLM-----QSK----FYIASDVWSFGVTLHELLTYCD-SDSSPMALF-LKMIGPTHGQM---TVTRLVNTL----KEGKR----LPCPPNCP-------------------------------------------DEVYQ-LMRKCWEFQPSNRTS------FQ-NLIE---GF-------------
----LKFLQQLGKGNFGSVEMCRY---DP------------LQDNTGEVVAVKKL---Q-H--S-TE--EH-LRD-FE-R-------------------------EIEILKSL--Q---HDNIVKYKGVCYSAG----------RRN--LK--LIMEYLPYG--SLRDYLQ-----KH--------------------------------------------------------------------------------------------------K-ERI---DHIKLLQYTSQICKGMEYLGT--K--R---YIHRDLATRNILVE-N-----EN-RV---KIGDFGLTKVL--PQ---D--KEYY--------------KVKEPGESPIFWYAPESLT-----ESK----FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM---IVFHLIELL----KNNGR----LPRPDGCP-------------------------------------------DEIYM-IMTECWNNNVNQRPS------FR-DLA----LRV------------
---L-KYISQLGKGNFGSVELCRY---DP------------LGDNTGALVAVKQL---Q-H--S-GP-DQ--QRD-FQ-R-------------------------EIQILKAL--H---SDFIVKYRGVSYGPG----------RQS--LR--LVMEYLPSG--CLRDFLQ-----RH--------------------------------------------------------------------------------------------------R-ARL---DASRLLLYSSQICKGMEYLGS--R--R---CVHRDLAARNILVE-S-----EA-HV---KIADFGLAKLL--PL---D--KDYY--------------VVREPGQSPIFWYAPESLS-----DNI----FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDV-P-ALCRLLELL----EEGQR----LPAPPACP-------------------------------------------AEVHE-LMKLCWAPSPQDRPS------FS-ALGP---QL-------------
----YEIDRTIGKGNFAVVKRATH---L----------------VTKAKVAIKII---DKT--Q-LDEEN---LK-KIFR-------------------------EVQIMKML--C---HPHIIRLYQVME--T----------ERM--IY--LVTEYASGG--EIFDHLV----AHG-----------------------------------------------------------------------------------------------------RM---AEKEARRKFKQIVTAVYFCHC--R--N---IVHRDLKAENLLLD-A-----NL-NI---KIADFGFSNL--------FTPGQLL--------------KT---WCGSPPYAAPELFE----GKEY----DGPKVDIWSLGVVLYVLVC-GA-LP---------------FDGS------TLQNLR----ARVLS----GKFRIPFFMS-----------------------------------------TECEH-LIRHMLVLDPNKRLS------ME-QICKHKWM--------------
----LSFGKTLGAGAFGKVVEATA---YG-----------LIKSDAAMTVAVKML---K-P--S-AH-LTE-REA-LM-S-------------------------ELKVLSYLG-N---HMNIVNLLGACT--I----------GGP--TL--VITEYCCYG--DLLNFLR-----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDE-LAL---DLEDLLSFSYQVAKGMAFLAS--K--N---CIHRDLAARNILLT-H-----GR-IT---KICDFGLARDI---K---N--DSNY--------------VVKGNARLPVKWMAPESIF-----NCV----YTFESDVWSYGIFLWELFSLGS-SP---------------YPGM-P-VDSKFYKMI----KEGFR----MLSPEHAP-------------------------------------------AEMYD-IMKTCWDADPLKRPT------FK-QIVQL--I--------------
---V-TLLRALGHGAFGEVYEGLV---IG-----------LPGDSSPLQVAIKTL---P-E--L-CS-PQD-ELD-FL-M-------------------------EALIISKF--R---HQNIVRCVGLSL--R----------ATP--RL--ILLELMSGG--DMKSFLR-----HSRP--------------------------------------------------------------------------------------------HLGQP-SPL---VMRDLLQLAQDIAQGCHYLEE--N--H---FIHRDIAARNCLLS-CA--GPSR-VA---KIGDFGMARDI---Y---R--ASYY--------------RRGDRALLPVKWMPPEAFL-----EGI----FTSKTDSWSFGVLLWEIFSLGY-MP---------------YPGR---TNQEVLDFV----VGGGR----MDPPRGCP-------------------------------------------GPVYR-IMTQCWQHEPELRPS------FA-SILERL----------------
----FEKISELGAGNGGVVFKVSH---K----------------PSGL-VMARKL---IHL--E-IKPAI---RN-QIIR-------------------------ELQVLHEC--N---SPYIVGFYGAFY--S----------DGE--IS--ICMEHMDGG--SLDQVLK----KAG-----------------------------------------------------------------------------------------------------RI---PEQILGKVSIAVIKGLTYLRE-KH--K---IMHRDVKPSNILVN-S-----RG-EI---KLCDFGVSG---------QLIDSMA--------------NS---FVGTRSYMSPERLQ-----GTH----YSVQSDIWSMGLSLVEMAV-GR-YP---------------IPPP---DAKELELMF----GCQVE----GDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQD-FVNKCLIKNPAERAD------LK-QLMVHAFI--------------
----IEVEEVVGRGAFGVVCKAKW---R------------------AKDVAIKQI---E-------S-ESE-RKA-FI-V-------------------------ELRQLSRV--N---HPNIVKLYGACL--------------NP--VC--LVMEYAEGG--SLYNVLH-----GA-------------------------------------------------------------------------------------------------EPLPYY---TAAHAMSWCLQCSQGVAYLHS--M--QPKALIHRDLKPPNLLLV-A-----GGTVL---KICDFGTACDI-------------Q--------------THMTNNKGSAAWMAPEVFE-----GSN----YSEKCDVFSWGIILWEVITR-R-KP---------------FDEIGG-PAFRIMWAV----HNGTR----PPLIKNLP-------------------------------------------KPIES-LMTRCWSKDPSQRPS------ME-EIVKI--M--------------
----YRLLKTIGKGNFAKVKLARH---I----------------LTGKEVAVKII---DKT--Q-LNSSS---LQ-KLFR-------------------------EVRIMKVL--N---HPNIVKLFEVIE--T----------EKT--LY--LVMEYASGG--EVFDYLV----AHG-----------------------------------------------------------------------------------------------------RM---KEKEARAKFRQIVSAVQYCHQ--K--F---IVHRDLKAENLLLD-A-----DM-NI---KIADFGFSNE--------FTFGNKL--------------DT---FCGSPPYAAPELFQ----GKKY----DGPEVDVWSLGVILYTLVS-GS-LP---------------FDGQ------NLKELR----ERVLR----GKYRIPFYMS-----------------------------------------TDCEN-LLKKFLILNPSKRGT------LE-QIMKDRWM--------------
----YRLLRTIGKGNFAKVKLARH---I----------------LTGREVAIKII---DKT--Q-LNPSS---LQ-KLFR-------------------------EVRIMKGL--N---HPNIVKLFEVIE--T----------EKT--LY--LVMEYASAG--EVFDYLV----SHG-----------------------------------------------------------------------------------------------------RM---KEKEARAKFRQIVSAVHYCHQ--K--N---IVHRDLKAENLLLD-A-----EA-NI---KIADFGFSNE--------FTLGSKL--------------DT---FCGSPPYAAPELFQ----GKKY----DGPEVDIWSLGVILYTLVS-GS-LP---------------FDGH------NLKELR----ERVLR----GKYRVPFYMS-----------------------------------------TDCES-ILRRFLVLNPAKRCT------LE-QIMKDKWI--------------
----LTLGAQIGEGEFGAVLQGEY---L------------------GQKVAVKNI---K-C--D-VT-AQ----A-FL-D-------------------------ETAVMTKM--Q---HENLVRLLGVIL-------------HQG--LY--IVMEHVSKG--NLVNFLR-----TR-------------------------------------------------------------------------------------------------GR-ALV---NTAQLLQFSLHVAEGMEYLES--K--K---LVHRDLAARNILVS-E-----DL-VA---KVSDFGLAKAE-------------R--------------KGLDSSRLPVKWTAPEALK-----HGK----FTSKSDVWSFGVLLWEVFSYGR-AP---------------YPKM---SLKEVSEAV----EKGYR----MEPPEGCP-------------------------------------------GPVHV-LMSSCWEAEPARRPP------FR-KLAEKL----------------
----VHFNEVIGRGHFGCVYHGTL---L-------------DNDGKKIHCAVKSL---N-R--I-TD-IGE-VSQ-FL-T-------------------------EGIIMKDF--S---HPNVLSLLGICL-RS----------EGS--PL--VVLPYMKHG--DLRNFIR-----NE--------------------------------------------------------------------------------------------------T-HNP---TVKDLIGFGLQVAKGMKYLAS--K--K---FVHRDLAARNCMLD-E-----KF-TV---KVADFGLARDM---Y---D--KEYYS------------VHNKTGAKLPVKWMALESLQ-----TQK----FTTKSDVWSFGVLLWELMTRGA-PP---------------YPDV---NTFDITVYL----LQGRR----LLQPEYCP-------------------------------------------DPLYE-VMLKCWHPKAEMRPS------FS-ELVSR--I--------------
----FTKLERIGKGSFGEVFKGID---N----------------RTQQVVAIKII---DLE--E-AEDEI---ED-IQ-Q-------------------------EITVLSQC--D---SSYVTKYYGSYL--K----------GSK--LW--IIMEYLGGG--SALDLLR-----AG-----------------------------------------------------------------------------------------------------PF---DEFQIATMLKEILKGLDYLHS--E--K---KIHRDIKAANVLLS-E-----QG-DV---KLADFGVAGQL-------TDTQIKR--------------NT---FVGTPFWMAPEVIQ-----QSA----YDSKADIWSLGITAIELAK-GE-PP---------------NSDM---HPMRVLFLI----PKNNP----PTLVGDFT-------------------------------------------KSFKE-FIDACLNKDPSFRPT------AK-ELLKHKFI--------------
---I-EYVRDIGEGAFGRVFQARA---PG-----------LLPYEPFTMVAVKML---K-E--E-AS-ADM-QAD-FQ-R-------------------------EAALMAEF--D---NPNIVKLLGVCA--V----------GKP--MC--LLFEYMAYG--DLNEFLR-----SMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGP-PPL---SCAEQLCIARQVAAGMAYLSE--R--K---FVHRDLATRNCLVG-E-----NM-VV---KIADFGLSRNI---Y---S--ADYY--------------KANENDAIPIRWMPPESIF-----YNR----YTTESDVWAYGVVLWEIFSYGL-QP---------------YYGM---AHEEVIYYV----RDGNI----LSCPENCP-------------------------------------------VELYN-LMRLCWSKLPADRPS------FT-SIHRIL----------------
---I-VLKRELGEGAFGKVFLAEC---YN-----------LCPEQDKILVAVKTL---K-D--A-SD-NA--RKD-FH-R-------------------------EAELLTNL--Q---HEHIVKFYGVCV--E----------GDP--LI--MVFEYMKHG--DLNKFLR-----AHGPDAV--------------------------------------------------------------------------------------LMAEGNPP-TEL---TQSQMLHIAQQIAAGMVYLAS--Q--H---FVHRDLATRNCLVG-E-----NL-LV---KIGDFGMSRDV---Y---S--TDYY--------------RVGGHTMLPIRWMPPESIM-----YRK----FTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL---SNNEVIECI----TQGRV----LQRPRTCP-------------------------------------------QEVYE-LMLGCWQREPHMRKN------IK-GIHTL--L--------------
---I-VLKRELGEGAFGKVFLAEC---YN-----------LSPTKDKMLVAVKAL---K-D--P-TL-AA--RKD-FQ-R-------------------------EAELLTNL--Q---HEHIVKFYGVCG--D----------GDP--LI--MVFEYMKHG--DLNKFLR-----AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAK-GEL---GLSQMLHIASQIASGMVYLAS--Q--H---FVHRDLATRNCLVG-A-----NL-LV---KIGDFGMSRDV---Y---S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----YRK----FTTESDVWSFGVILWEIFTYGK-QP---------------WFQL---SNTEVIECI----TQGRV----LERPRVCP-------------------------------------------KEVYD-VMLGCWQREPQQRLN------IK-EIYKIL----------------
----YELQETLGKGTYGKVKRATE---R----------------FSGRVVAIKSI---RKD--K-IKDEQ---DM-VHIR------------------------REIEIMSSL--N---HPHIISIYEVFE--N----------KDK--IV--IIMEYASKG--ELYDYIS----ERR-----------------------------------------------------------------------------------------------------RL---SERETRHFFRQIVSAVHYCHK--N--G---VVHRDLKLENILLD-D-----NC-NI---KIADFGLSNL--------YQKDKFL--------------QT---FCGSPLYASPEIVN----GRPY----RGPEVDSWALGVLLYTLVY-GT-MP---------------FDGF------DHKNLI----RQISS----GEYREPTQP------------------------------------------SDARG-LIRWMLMVNPDRRAT------IE-DIANHWW-V-------------
----YEFLETLGKGTYGKVKKARE---S----------------SGR-LVAIKSI---RKD--K-IKDEQ---DL-MHIR------------------------REIEIMSSL--N---HPHIIAIHEVFE--N----------SSK--IV--IVMEYASRG--DLYDYIS----ERQ-----------------------------------------------------------------------------------------------------QL---SEREARHFFRQIVSAVHYCHQ--N--R---VVHRDLKLENILLD-A-----NG-NI---KIADFGLSNL--------YHQGKFL--------------QT---FCGSPLYASPEIVN----GKPY----TGPEVDSWSLGVLLYILVH-GT-MP---------------FDGH------DHKILV----KQISN----GAYREPPK-----P-------------------------------------SDACG-LIRWLLMVNPTRRAT------LE-DVASHWW-V-------------
---L-VLGRVLGSGAFGKVVEGTA---YG-----------LSRSQPVMKVAVKML---K-P--T-AR-SSE-KQA-LM-S-------------------------ELKIMTHLG-P---HLNIVNLLGACT--K----------SGP--IY--IITEYCFYG--DLVNYLH-----KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNS-EGL---TLLDLLSFTYQVARGMEFLAS--K--N---CVHRDLAARNVLLA-Q-----GK-IV---KICDFGLARDI---M---H--DSNY--------------VSKGSTFLPVKWMAPESIF-----DNL----YTTLSDVWSYGILLWEIFSLGG-TP---------------YPGM-M-VDSTFYNKI----KSGYR----MAKPDHAT-------------------------------------------SEVYE-IMVKCWNSEPEKRPS------FY-HLSE---IV-------------
---L-VLGRTLGSGAFGQVVEATA---HG-----------LSHSQATMKVAVKML---K-S--T-AR-SSE-KQA-LM-S-------------------------ELKIMSHLG-P---HLNVVNLLGACT--K----------GGP--IY--IITEYCRYG--DLVDYLH-----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINES-PVL---SYMDLVGFSYQVANGMEFLAS--K--N---CVHRDLAARNVLIC-E-----GK-LV---KICDFGLARDI---M---R--DSNY--------------ISKGSTFLPLKWMAPESIF-----NSL----YTTLSDVWSFGILLWEIFTLGG-TP---------------YPEL-P-MNEQFYNAI----KRGYR----MAQPAHAS-------------------------------------------DEIYE-IMQKCWEEKFEIRPP------FS-QLVL---LL-------------
---F-KFGKILGEGSFSTVVLARE---L----------------ATSREYAIKIL---EKR--H-IIKEN---KVPYVTR-------------------------ERDVMSRL--D---HPFFVKLYFTFQ--D----------DEK--LY--FGLSYAKNG--ELLKYIR----KIG-----------------------------------------------------------------------------------------------------SF---DETCTRFYTAEIVSALEYLHG--K--G---IIHRDLKPENILLN-E-----DM-HI---QITDFGTAKVLS-----PESKQARA--------------NS---FVGTAQYVSPELLT-----EKS----ACKSSDLWALGCIIYQLVA-GL-PP---------------FRAG------NEYLIF----QKIIK----LEYDFPEKFF-----------------------------------------PKARD-LVEKLLVLDATKRLG------CE-EM------EGYGPLKAHPF---
---F-KFLAVLGRGHFGKVLLSEF---R----------------PSGELFAIKAL---KKG--D-IVARD---EV-ESLM------------------------CEKRILAAV--TSAGHPFLVNLFGCFQ--T----------PEH--VC--FVMEYSAGG--DLMLHIH-----SD-----------------------------------------------------------------------------------------------------VF---SEPRAIFYSACVVLGLQFLHE--H--K---IVYRDLKLDNLLLD-T-----EG-YV---KIADFGLCKEG-------MGYGDRT--------------ST---FCGTPEFLAPEVLT-----DTS----YTRAVDWWGLGVLLYEMLV-GE-SP---------------FPGD------DEEEVF----DSIVN----DEVRYPRFLS-----------------------------------------AEAIG-IMRRLLRRNPERRLGSS-ERDAE-DVKKQPFF--------------
--FR--CCAVLGRGHFGKVLLAEY---K----------------NTNEMFAIKAL---KKG--D-IVARD---EV-DSLM------------------------CEKRIFETV--NSVRHPFLVNLFACFQ--T----------KEH--VC--FVMEYAAGG--DLMMHIH-----TD-----------------------------------------------------------------------------------------------------VF---SEPRAVFYAACVVLGLQYLHE--H--K---IVYRDLKLDNLLLD-T-----EG-FV---KIADFGLCKEG-------MGYGDRT--------------ST---FCGTPEFLAPEVLT-----ETS----YTRAVDWWGLGVLIYEMLV-GE-SP---------------FPGD------DEEEVF----DSIVN----DEVRYPRFLS-----------------------------------------TEAIS-IMRRLLRRNPERRLGAS-EKDAE-DVKKHPFF--------------
---F-NFLMVLGKGSFGKVMLADR---K----------------GTEELYAIKIL---KKD--V-VIQDD---DV-ECTM------------------------VEKRVLALL-DK---PPFLTQLHSCFQ--T----------VDR--LY--FVMEYVNGG--DLMYHIQ----QVG-----------------------------------------------------------------------------------------------------KF---KEPQAVFYAAEISIGLFFLHK--R--G---IIYRDLKLDNVMLD-S-----EG-HI---KIADFGMCKEH-------MMDGVTT--------------RT---FCGTPDYIAPEIIA-----YQP----YGKSVDWWAYGVLLYEMLA-GQ-PP---------------FDGE------DEDELF----QSIME----HNVSYPKSLS-----------------------------------------KEAVS-VCKGLMTKHPAKRLG------C----------GPEGERDVREHAFF
---F-NFLMVLGKGSFGKVMLSER---K----------------GTDELYAVKIL---KKD--V-VIQDD---DV-ECTM------------------------VEKRVLALP-GK---PPFLTQLHSCFQ--T----------MDR--LY--FVMEYVNGG--DLMYHIQ----QVG-----------------------------------------------------------------------------------------------------RF---KEPHAVFYAAEIAIGLFFLQS--K--G---IIYRDLKLDNVMLD-S-----EG-HI---KIADFGMCKEN-------IWDGVTT--------------KT---FCGTPDYIAPEIIA-----YQP----YGKSVDWWAFGVLLYEMLA-GQ-AP---------------FEGE------DEDELF----QSIME----HNVAYPKSMS-----------------------------------------KEAVA-ICKGLMTKHPGKRLG------C----------GPEGERDIKEHAFF
----FEFIRVLGKGSFGKVMLARV---K----------------ETGDLYAVKVL---KKD--V-ILQDD---DV-ECTM------------------------TEKRILSLA-RN---HPFLTQLFCCFQ--T----------PDR--LF--FVMEFVNGG--DLMFHIQ----KSR-----------------------------------------------------------------------------------------------------RF---DEARARFYAAEIISALMFLHD--K--G---IIYRDLKLDNVLLD-H-----EG-HC---KLADFGMCKEG-------ICNGVTT--------------AT---FCGTPDYIAPEILQ-----EML----YGPAVDWWAMGVLLYEMLC-GH-AP---------------FEAE------NEDDLF----EAILN----DEVVYPTWLH-----------------------------------------EDATG-ILKSFMTKNPTMRLGSLTQGGEH-AILRHPF-F-------------
--FI--LHKMLGKGSFGKVFLAEF---K----------------KTNQFFAIKAL---KKD--V-VLMDD---DV-ECTM------------------------VEKRVLSLA-WE---HPFLTHMFCTFQ--T----------KEN--LF--FVMEYLNGG--DLMYHIQ----SCH-----------------------------------------------------------------------------------------------------KF---DLSRATFYAAEIILGLQFLHS--K--G---IVYRDLKLDNILLD-K-----DG-HI---KIADFGMCKEN-------MLGDAKT--------------NT---FCGTPDYIAPEILL-----GQK----YNHSVDWWSFGVLLYEMLI-GQ-SP---------------FHGQ------DEEELF----HSIRM----DNPFYPRWLE-----------------------------------------KEAKD-LLVKLFVREPEKRLG------VRGDIRQHPLF--------------
---F-TLCRKLGSGYFGEVFEGLW---K-----------------DRVQVAIKVI---S-R--D-NL-LH--QQM-LQ-S-------------------------EIQAMKKL--R---HKHILALYAVVS--V----------GDP--VY--IITELMAKG--SLLELLR-----DS-------------------------------------------------------------------------------------------------DE-KVL---PVSELLDIAWQVAEGMCYLES--Q--N---YIHRDLAARNILVG-E-----NT-LC---KVGDFGLARLI----------KEDV--------------YLSHDHNIPYKWTAPEALS-----RGH----YSTKSDVWSFGILLHEMFSRGQ-VP---------------YPGM---SNHEAFLRV----DAGYR----MPCPLECP-------------------------------------------PSVHK-LMLTCWCRDPEQRPC------FK-ALRERL----------------
--VM--LSTRIGSGSFGTVYKGKW---H-------------------GDVAVKIL---K-V-VD-PT-PEQ-FQA-FR-N-------------------------EVAVLRKT--R---HVNILLFMGYMT-------------KDN--LA--IVTQWCEGS--SLYKHLH-----VQ--------------------------------------------------------------------------------------------------E-TKF---QMFQLIDIARQTAQGMDYLHA--K--N---IIHRDMKSNNIFLH-E-----GL-TV---KIGDFGLATVK---S---R--WSGS--------------QQVEQPTGSVLWMAPEVIR-----MQDN-NPFSFQSDVYSYGIVLYELMT-GE-LP---------------YSHI-N-NRDQIIFMV----GRGYASPDLSKLYKNCP-------------------------------------------KAMKR-LVADCVKKVKEERPL------FP-QILSS--I--------------
---L-VLGKTLGEGEFGKVVKATA---FH-----------LKGRAGYTTVAVKML---K-E--N-AS-PSE-LRD-LL-S-------------------------EFNVLKQV--N---HPHVIKLYGACS--Q----------DGP--LL--LIVEYAKYG--SLRGFLR-----ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDE-RAL---TMGDLISFAWQISQGMQYLAE--M--K---LVHRDLAARNILVA-E-----GR-KM---KISDFGLSRDV---Y---E--EDSY--------------VKRSQGRIPVKWMAIESLF-----DHI----YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI---PPERLFNLL----KTGHR----MERPDNCS-------------------------------------------EEMYR-LMLQCWKQEPDKRPV------FA-DISKDL----------------
-LAD---LRYLSRGASGTVSSARH---A----------------DWRVQVAVKHL---HIH--T-PLLDS---ER-KDVL------------------------REAEILHKA--R---FSYILPILGICN--E----------PEF--LG--IVTEYMPNG--SLNELLH----RKT-----------------------------------------------------------------------------------------------------EYPDVAWPLRFRILHEIALGVNYLHN--MTPP---LLHHDLKTQNILLD-N-----EF-HV---KIADFGLSKWRMM--SLSQSRSSKS--------------AP---EGGTIIYMPPENYEP--GQKSR----ASIKHDIYSYAVITWEVLS-RK-QP---------------FEDVT-NPLQIMYSVS----QGHRP----VINEESLPYDIPHR-------------------------------------ARMIS-LIESGWAQNPDERPS------FL-KCL-----IEL-----------
FTGW----EKVGSGGFGQVYKVRH---V----------------HWKTWLAIKCS---PSL--H-VDDRE---RM-ELLE-------------------------EAKKMEMA--K---FRYILPVYGIC--------------REP--VG--LVMEYMETG--SLEKLLA-----SE-----------------------------------------------------------------------------------------------------PL---PWDLRFRIIHETAVGMNFLHC--MAPP---LLHLDLKPANILLD-A-----HY-HV---KISDFGLAKCNG----LSHSHDLSM--------------DG---LFGTIAYLPPERIR---EKSRL----FDTKHDVYSFAIVIWGVLT-QK-KP---------------FADE--KNILHIMVKV----VKGHR----PELPPVCRARPRAC-------------------------------------SHLIR-LMQRCWQGDPRVRPT------FQ---------GNGLN---------
--LT--LRLLLGSGAFGEVYEGTA---VDI----------LGVGSGEIKVAVKTL---K-K--G-ST-DQE-KIE-FL-K-------------------------EAHLMSKF--N---HPNILKQLGVCL--L----------NEP--QY--IILELMEGG--DLLTYLR-----KARM--------------------------------------------------------------------------------------------ATFYG-PLL---TLVDLVDLCVDISKGCVYLER--M--H---FIHRDLAARNCLVS-VKDYTSPR-IV---KIGDFGLARDI---Y---K--NDYY--------------RKRGEGLLPVRWMAPESLM-----DGI----FTTQSDVWSFGILIWEILTLGH-QP---------------YPAH---SNLDVLNYV----QTGGR----LEPPRNCP-------------------------------------------DDLWN-LMTQCWAQEPDQRPT------FH-RIQDQL----------------
----FELLRVLGKGGYGKVFQVRKVTGA----------------NTGKIFAMKVL---KKA--M-IVRNA---KD-TAHTK-----------------------AERNILEEV--K---HPFIVDLIYAFQ--T----------GGK--LY--LILEYLSGG--ELFMQLE----REG-----------------------------------------------------------------------------------------------------IF---MEDTACFYLAEISMALGHLHQ--K--G---IIYRDLKPENIMLN-H-----QG-HV---KLTDFGLCKES-------IHDGTVT--------------HT---FCGTIEYMAPEILM-----RSG----HNRAVDWWSLGALMYDMLT-GA-PP---------------FTGE------NRKKTI----DKILK----CKLNLPPYLT-----------------------------------------QEARD-LLKKLLKRNAASRLGAG-PGDAG-EVQAHPFF--------------
----YDIERTLGKGNFAVVKLARH---R----------------VTKTQVAIKII---DKT--R-LDSSN---LE-KIYR-------------------------EVQLMKLL--N---HPHIIKLYQVME--T----------KDM--LY--IVTEFAKNG--EMFDYLT----SNG-----------------------------------------------------------------------------------------------------HL---SENEARKKFWQILSAVEYCHD--H--H---IVHRDLKTENLLLD-G-----NM-DI---KLADFGFGNF--------YKSGEPL--------------ST---WCGSPPYAAPEVFE----GKEY----EGPQLDIWSLGVVLYVLVC-GS-LP---------------FDGP------NLPTLR----QRVLE----GRFRIPFFMS-----------------------------------------QDCES-LIRRMLVVDPARRIT------IA-QIRQHRWM--------------
----YDIEGTLGKGNFAVVKLGRH---R----------------ITKTEVAIKII---DKS--Q-LDAVN---LE-KIYR-------------------------EVQIMKML--D---HPHIIKLYQVME--T----------KSM--LY--LVTEYAKNG--EIFDYLA----NHG-----------------------------------------------------------------------------------------------------RL---NESEARRKFWQILSAVDYCHG--R--K---IVHRDLKAENLLLD-N-----NM-NI---KIADFGFGNF--------FKSGELL--------------AT---WCGSPPYAAPEVFE----GQQY----EGPQLDIWSMGVVLYVLVC-GA-LP---------------FDGP------TLPILR----QRVLE----GRFRIPYFMS-----------------------------------------EDCEH-LIRRMLVLDPSKRLT------IA-QIKEHKWM--------------
----WEIIGELGDGAFGKVYKAQN---K----------------ETSVLAAAKVI---DTK--S-EEELE---DY-M--V-------------------------EIDILASC--D---HPNIVKLLDAFY--Y----------ENN--LW--ILIEFCAGG--AVDAVML---ELER-----------------------------------------------------------------------------------------------------PL---TESQIQVVCKQTLDALNYLHD--N--K---IIHRDLKAGNILFT-L-----DG-DI---KLADFGVSAKN-------TRTIQRR--------------DS---FIGTPYWMAPEVVMCETSKDRP----YDYKADVWSLGITLIEMAE-IE-PP---------------HHEL---NPMRVLLKI----AKSEP----PTLAQPSRWS-----------------------------------------SNFKD-FLKKCLEKNVDARWT------TS-QLLQHPFV--------------
---L-RLEVKLGQGCFGEVWMGTW---N-----------------GTTRVAIKTL---K-P--G-TM-SP---EA-FL-Q-------------------------EAQVMKKL--R---HEKLVQLYAVVS-------------EEP--IY--IVTEYMSKG--SLLDFLK-----GE-------------------------------------------------------------------------------------------------TG-KYL---RLPQLVDMAAQIASGMAYVER--M--N---YVHRDLRAANILVG-E-----NL-VC---KVADFGLARLI-------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR----FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM---VNREVLDQV----ERGYR----MPCPPECP-------------------------------------------ESLHD-LMCQCWRKEPEERPT------FE-YLQAF--L--------------
--FA--LGRKLGEGYFGEVWEGLW---L-----------------GSLPVAIKVI---K-S--A-NM-K---LTD-LA-K-------------------------EIQTLKGL--R---HERLIRLHAVCS--G----------GEP--VY--IVTELMRKG--NLQAFLG-----TP-------------------------------------------------------------------------------------------------EG-RAL---RLPPLLGFACQVAEGMSYLEE--Q--R---VVHRDLAARNVLVD-D-----GL-AC---KVADFGLARLL-------K--DDIY--------------SPSSSSKIPVKWTAPEAAN-----YRV----FSQKSDVWSFGVLLHEVFTYGQ-CP---------------YEGM---TNHETLQQI----MRGYR----LPRPAACP-------------------------------------------AEVYV-LMLECWRSSPEERPS------FA-TLREKL----------------
----WEIVGELGDGAFGKVYKAKN---K----------------ETGALAAAKVI---ETK--S-EEELE---DY-I--V-------------------------EIEILATC--D---HPYIVKLLGAYY--H----------DGK--LW--IMIEFCPGG--AVDAIML---ELDR-----------------------------------------------------------------------------------------------------GL---TEPQIQVVCRQMLEALNFLHS--K--R---IIHRDLKAGNVLMT-L-----EG-DI---RLADFGVSAKN-------LKTLQKR--------------DS---FIGTPYWMAPEVVMCETMKDTP----YDYKADIWSLGITLIEMAQ-IE-PP---------------HHEL---NPMRVLLKI----AKSDP----PTLLTPSKWS-----------------------------------------VEFRD-FLKIALDKNPETRPS------AA-QLLEHPFV--------------
-LCP---GRELGRGKFAVVRKCIK---K----------------DSGKEFAAKFM---RKR--R-KGQDC---RM-EIIH-------------------------EIAVLELA-QD---NPWVINLHEVYE--T----------ASE--MI--LVLEYAAGG--EIFDQCVA--DREE-----------------------------------------------------------------------------------------------------AF---KEKDVQRLMRQILEGVHFLHT--R--D---VVHLDLKPQNILLT-S-----ES-PLGDIKIVDFGLSRI--------LKNSEEL--------------RE---IMGTPEYVAPEILS-----YDP----ISMATDMWSIGVLTYVMLT-GI-SP---------------FLGN------DKQETF----LNISQ----MNLSYSEEEFDVLS-------------------------------------ESAVD-FIRTLLVKKPEDRAT------AE-ECLKHPWL--------------
----FTKLEKIGKGSFGEVFKGID---N----------------RTQKVVAIKII---DLE--E-AEDEI---ED-IQ-Q-------------------------EITVLSQC--D---SPYVTKYYGSYL--K----------DTK--LW--IIMEYLGGG--SALDLLE-----PG-----------------------------------------------------------------------------------------------------PL---DETQIATILREILKGLDYLHS--E--K---KIHRDIKAANVLLS-E-----HG-EV---KLADFGVAGQL-------TDTQIKR--------------NT---FVGTPFWMAPEVIK-----QSA----YDSKADIWSLGITAIELAR-GE-PP---------------HSEL---HPMKVLFLI----PKNNP----PTLEGNYS-------------------------------------------KPLKE-FVEACLNKEPSFRPT------AK-ELLKHKFI--------------
---F-TKLDRIGKGSFGEVYKGID---N----------------HTKEVVAIKII---DLE--E-AEDEI---ED-IQ-Q-------------------------EITVLSQC--D---SPYITRYFGSYL--K----------STK--LW--IIMEYLGGG--SALDLLK-----PG-----------------------------------------------------------------------------------------------------PL---EETYIATILREILKGLDYLHS--E--R---KIHRDIKAANVLLS-E-----QG-DV---KLADFGVAGQL-------TDTQIKR--------------NT---FVGTPFWMAPEVIK-----QSA----YDFKADIWSLGITAIELAK-GE-PP---------------NSDL---HPMRVLFLI----PKNSP----PTLEGQHS-------------------------------------------KPFKE-FVEACLNKDPRFRPT------AK-ELLKHKFI--------------
-TLE---DKELGSGNFGTVKKGYY---Q--------------MKKVVKTVAVKIL---K-N--E-AN-DPALKDE-LL-A-------------------------EANVMQQL--D---NPYIVRMIGICE-------------AES--WM--LVMEMAELG--PLNKYLQ-----QN----------------------------------------------------------------------------------------------------RHV---KDKNIIELVHQVSMGMKYLEE--S--N---FVHRDLAARNVLLV-T-----QH-YA---KISDFGLSKAL---R---A--DENY-------------YKAQTHGKWPVKWYAPECIN-----YYK----FSSKSDVWSFGVLMWEAFSYGQ-KP---------------YRGM---KGSEVTAML----EKGER----MGCPAGCP-------------------------------------------REMYD-LMNLCWTYDVENRPG------FA-AVE----LRL------------
----LTFMRELGSGLFGVVRLGKW---R-----------------AQYKVAIKAI---R-E--G-AM-CE---ED-FI-E-------------------------EAKVMMKL--T---HPKLVQLYGVCT--Q----------QKP--IY--IVTEFMERG--CLLNFLR-----QR--------------------------------------------------------------------------------------------------Q-GHF---SRDVLLSMCQDVCEGMEYLER--N--S---FIHRDLAARNCLVS-E-----AG-VV---KVSDFGMARYV-------L--DDQY--------------TSSSGAKFPVKWCPPEVFN-----YSR----FSSKSDVWSFGVLMWEVFTEGR-MP---------------FEKY---TNYEVVTMV----TRGHR----LYQPKLAS-------------------------------------------NYVYE-VMLRCWQEKPEGRPS------FE-DLLRT--I--------------
----IKFQDVIGEGNFGQVLKARI---K--------------KDGLRMDAAIKRM---K-E--Y-AS-KDD-HRD-FA-G-------------------------ELEVLCKLG-H---HPNIINLLGACE--H----------RGY--LY--LAIEYAPHG--NLLDFLR-----KSRVLETDP-----------------------------------------------------------------------------------AFAIANSTA-STL---SSQQLLHFAADVARGMDYLSQ--K--Q---FIHRDLAARNILVG-E-----NY-VA---KIADFGLSRGQ-----------EVY--------------VKKTMGRLPVRWMAIESLN-----YSV----YTTNSDVWSYGVLLWEIVSLGG-TP---------------YCGM---TCAELYEKL----PQGYR----LEKPLNCD-------------------------------------------DEVYD-LMRQCWREKPYERPS------FA-QILV---SL-------------
----ITFEDLIGEGNFGQVIRAMI---K--------------KDGLKMNAAIKML---K-E--Y-AS-END-HRD-FA-G-------------------------ELEVLCKLG-H---HPNIINLLGACK--N----------RGY--LY--IAIEYAPYG--NLLDFLR-----KSRVLETDP-----------------------------------------------------------------------------------AFAREHGTA-STL---SSRQLLRFASDAANGMQYLSE--K--Q---FIHRDLAARNVLVG-E-----NL-AS---KIADFGLSRGE-----------EVY--------------VKKTMGRLPVRWMAIESLN-----YSV----YTTKSDVWSFGVLLWEIVSLGG-TP---------------YCGM---TCAELYEKL----PQGYR----MEQPRNCD-------------------------------------------DEVYE-LMRQCWRDRPYERPP------FA-QIALQ--L--------------
-VCR---GELLGSGCFGVVHRGLW---T-------------LPSGKSVPVAVKSLRVGP-E--G-PM-GTE-LGD-FL-R-------------------------EVSVMMNL--E---HPHVLRLHGLVL-------------GQP--LQ--MVMELAPLG--SLHARLT-----AP------------------------------------------------------------------------------------------------APT-PPL---LVALLCLFLRQLAGAMAYLGA--R--G---LVHRDLATRNLLLA-S-----PR-TI---KVADFGLVRPL--GG---A--RGRY--------------VMGGPRPIPYAWCAPESLR-----HGA----FSSASDVWMFGVTLWEMFSGGE-EP---------------WAGV---PPYLILQRL----EDRAR----LPRPPLCS-------------------------------------------RALYS-LALRCWAPHPADRPS------FS-HLE----GLL------------
---L-RLLEKLGDGSFGVVRRGEW---D-------------APSGKTVSVAVKCL---K-PDVL-SQ-PEA-MDD-FI-R-------------------------EVNAMHSL--D---HRNLIRLYGVVL-------------TPP--MK--MVTELAPLG--SLLDRLR-----KH--------------------------------------------------------------------------------------------------Q-GHF---LLGTLSRYAVQVAEGMGYLES--K--R---FIHRDLAARNLLLA-T-----RD-LV---KIGDFGLMRAL--PQ---N--DDHY--------------VMQEHRKVPFAWCAPESLK-----TRT----FSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL---NGSQILHKI---DKEGER----LPRPEDCP-------------------------------------------QDIYN-VMVQCWAHKPEDRPT------FV-ALRDF--L--------------
----IEFHEIIGSGSFGKVYKGRC---R------------------NKIVAIKRY---R-ANTY-CS-KSD-VDM-FC-R-------------------------EVSILCQL--N---HPCVIQFVGACL-ND----------PSQ--FA--IVTQYISGG--SLFSLLH-----EQ--------------------------------------------------------------------------------------------------K-RIL---DLQSKLIIAVDVAKGMEYLHNLTQ--P---IIHRDLNSHNILLY-E-----DG-HA---VVADFGESRFL---Q---S--LD-E--------------DNMTKQPGNLRWMAPEVFT-----QCT---RYTIKADVFSYALCLWEILT-GE-IP---------------FAHL---KPAAAAADM---AYHHIR----PPIGYSIP-------------------------------------------KPISS-LLIRGWNACPEGRPE------FS-EVVMKL----------------
---L-AFIKEIGSGQFGVVHLGEW---R-----------------SHIQVAIKAI---N-E--G-SM-SE---ED-FI-E-------------------------EAKVMMKL--S---HSKLVQLYGVCI--Q----------RKP--LY--IVTEFMENG--CLLNYLR-----EN--------------------------------------------------------------------------------------------------K-GKL---RKEMLLSVCQDICEGMEYLER--N--G---YIHRDLAARNCLVS-S-----TC-IV---KISDFGMTRYV-------L--DDEY--------------VSSFGAKFPIKWSPPEVFL-----FNK----YSSKSDVWSFGVLMWEVFTEGK-MP---------------FENK---SNLQVVEAI----SEGFR----LYRPHLAP-------------------------------------------MSIYE-VMYSCWHEKPEGRPT------FA-ELLR---AV-------------
---L-RLEVKLGQGCFGEVWMGTW---N-----------------GTTKVAIKTL---K-P--G-TM-MP---EA-FL-Q-------------------------EAQIMKKL--R---HDKLVPLYAVVS-------------EEP--IY--IVTEFMSKG--SLLDFLK-----EG-------------------------------------------------------------------------------------------------DG-KYL---KLPQLVDMAAQIADGMAYIER--M--N---YIHRDLRAANILVG-E-----NL-VC---KIADFGLARLI-------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR----FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM---VNREVLEQV----ERGYR----MPCPQGCP-------------------------------------------ESLHE-LMNLCWKKDPDERPT------FE-YIQSFL----------------
LIAD----IELGCGNFGSVRQGVY---R--------------MRKKQIDVAIKVL---K-Q--G-TE-KAD-TEE-MM-R-------------------------EAQIMHQL--D---NPYIVRLIGVCQ-------------AEA--LM--LVMEMAGGG--PLHKFLV-----GK--------------------------------------------------------------------------------------------------R-EEI---PVSNVAELLHQVSMGMKYLEE--K--N---FVHRDLAARNVLLV-N-----RH-YA---KISDFGLSKAL--GA---D--DSYY--------------TARSAGKWPLKWYAPECIN-----FRK----FSSRSDVWSYGVTMWEALSYGQ-KP---------------YKKM---KGPEVMAFI----EQGKR----MECPPECP-------------------------------------------PELYA-LMSDCWIYKWEDRPD------FL-TVEQR--M--------------
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