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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FGR 203
TK ABL1 261
TK ABL2 288
TKL ACVR1 208
TKL ACVR1B 207
TK ALK 1116
TK BLK 241
TKL BMPR1A 234
TKL BMPR1B 204
TK BMX 422
CAMK BRSK1 50
CAMK BRSK2 19
TK BTK 402
CMGC CDC2L5 705
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CAMK CHEK1 9
TK CSF1R 582
TK CSK 195
TK DDR1 572
TK EGFR 712
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB4 615
TK EPHB6 670
TK ERBB2 720
TK ERBB4 718
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FRK 234
TK FYN 271
TK HCK 241
CMGC ICK 4
TK INSR 1023
TKL IRAK4 186
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
CAMK KIAA0999 66
TK KIT 589
TK LCK 245
TK LTK 510
TK LYN 247
CMGC MAK 4
CMGC MAPK1 13
CMGC MAPK14 24
CAMK MARK2 53
CAMK MARK4 59
TK MATK 235
CAMK MGC42105 74
TK MUSK 575
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
CAMK NUAK2 97
STE OXSR1 17
TK PDGFRA 593
TK PDGFRB 600
AGC PKN1 615
AGC PKN2 657
AGC PRKCA 339
AGC PRKCD 349
AGC PRKCE 408
AGC PRKCQ 380
TK PTK6 191
TK RET 724
TK ROS1 1945
CAMK SIK1 27
CAMK SIK2 20
CAMK SNRK 16
TK SRC 270
TK SRMS 230
STE STK24 24
STE STK25 20
STE STK39 63
TK SYK 371
TK TEC 370
TKL TGFBR1 205
TK TNK1 116
TK TNK2 150
TK TXK 271
TK TYK2 589
TK YES1 277
TK ZAP70 338
----ITLERRLGTGCFGDVWLGTWN-----------------GSTKVAVKTL---K-P--GTM-SP---K-AFL-E-EAQVMKLL--R---HDKLVQLYAVVS-------------EEP--IYIVTEFMCHGSLLDFLK---------NP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERM--------NYIHRDLRAANILVG-E-----RLACKIADFGLARLI--------K--DDEY--------------NPCQGSKFPIKWTAPEAAL------FGRFTIKSDVWSFGILLTELITKGR--------------IP---------------YPGM-----NKREVLEQV----EQGYH---MPCPPGCP------------------------------ASLYE-AMEQTWRLDPEERPT-------FE-YLQSFL----------------
----ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTL---K-E--DTM-EV---E-EFL-K-EAAVMKEI--K---HPNLVQLLGVCT--R----------EPP--FYIITEFMTYGNLLDYLR---------EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVG-E-----NHLVKVADFGLSRLM--------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNKFSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYELL----EKDYR---MERPEGCP------------------------------EKVYE-LMRACWQWNPSDRPS-------FA-EIHQA--F--------------
----ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTL---K-E--DTM-EV---E-EFL-K-EAAVMKEI--K---HPNLVQLLGVCT--L----------EPP--FYIVTEYMPYGNLLDYLR---------EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVG-E-----NHVVKVADFGLSRLM--------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNTFSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYDLL----EKGYR---MEQPEGCP------------------------------PKVYE-LMRACWKWSPADRPS-------FA-ETHQA--F--------------
---I-TLLECVGKGRYGEVWRGSWQ----------------GEN--VAVKIF---SSR--DEKSWF---R-ET----ELYNTVML--R---HENILGFIASDM--TSR------HSSTQ--LWLITHYHEMGSLYDYLQ---------LT----------------------------------------------------------------------------------------------------TLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVK-K-----NGQCCIADLGLAVMHSQ----STNQLDVGN--------------NP---RVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVAR-RMVSNGI----VEDYKPP---------------FYDVVPNDPSFEDMRKVV----CVDQQ---RPNIPNRWFSDPTL------------------------TSLAK-LMKECWYQNPSARLT-------AL-RIKK----TL------------
--IV--LQEIIGKGRFGEVWRGRWR----------------GGD--VAVKIF---SSR--EERSWF---R-EA----EIYQTVML--R---HENILGFIAADN--KDN------GTWTQ--LWLVSDYHEHGSLFDYLN---------RY----------------------------------------------------------------------------------------------------TVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVK-K-----NGMCAIADLGLAVRHDA----VTDTIDIAP--------------NQ---RVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIAR-RCNSGGV----HEEYQLP---------------YYDLVPSDPSIEEMRKVV----CDQKL---RPNIPNWWQSYEAL------------------------RVMGK-MMRECWYANGAARLT-------AL-RIKK----TL------------
---I-TLIRGLGHGAFGEVYEGQVSG-----------MPNDPSPLQVAVKTL---P-E--VCS-EQD-EL-DFL-M-EALIISKF--N---HQNIVRCIGVSL--Q----------SLP--RFILLELMAGGDLKSFLR---------ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN--------HFIHRDIAARNCLLT-CP--GPGRVAKIGDFGMARDI----Y---R--ASYY--------------RKGGCAMLPVKWMPPEAFM------EGIFTSKTDTWSFGVLLWEIFSLGY--------------MP---------------YPSK-----SNQEVLEFV----TSGGR---MDPPKNCP------------------------------GPVYR-IMTQCWQHQPEDRPN-------FA-IILER--I--------------
---L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAIKTL---K-E--GTM-SP---E-AFL-G-EANVMKAL--Q---HERLVRLYAVVT-------------KEP--IYIVTEYMARGCLLDFLK---------TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERM--------NSIHRDLRAANILVS-E-----ALCCKIADFGLARII-----------DSEY--------------TAQEGAKFPIKWTAPEAIH------FGVFTIKADVWSFGVLLMEVVTYGR--------------VP---------------YPGM-----SNPEVIRNL----ERGYR---MPRPDTCP------------------------------PELYRGVIAECWRSRPEERPT-------FE-FLQSV--L--------------
---I-QMVRQVGKGRYGEVWMGKWR----------------GEK--VAVKVF---FTT--EEASWF---R-ET----EIYQTVLM--R---HENILGFIAADI--KGT------GSWTQ--LYLITDYHENGSLYDFLK---------CA----------------------------------------------------------------------------------------------------TLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIK-K-----NGSCCIADLGLAVKFNS----DTNEVDVPL--------------NT---RVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMAR-RCITGGI----VEEYQLP---------------YYNMVPSDPSYEDMREVV----CVKRL---RPIVSNRWNSDECL------------------------RAVLK-LMSECWAHNPASRLT-------AL-RIKK----TL------------
---I-QMVKQIGKGRYGEVWMGKWR----------------GEK--VAVKVF---FTT--EEASWF---R-ET----EIYQTVLM--R---HENILGFIAADI--KGT------GSWTQ--LYLITDYHENGSLYDYLK---------ST----------------------------------------------------------------------------------------------------TLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVK-K-----NGTCCIADLGLAVKFIS----DTNEVDIPP--------------NT---RVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVAR-RCVSGGIVEEYQLPYHD-------------------LVPSDPSYEDMREIV----CIKKL---RPSFPNRWSSDECL------------------------RQMGK-LMTECWAHNPASRLT-------AL-RVKK----TL------------
----ITLLKELGSGQFGVVQLGKWK-----------------GQYDVAVKMI---K-E--GSM-SE---D-EFF-Q-EAQTMMKL--S---HPKLVKFYGVCS--K----------EYP--IYIVTEYISNGCLLNYLR---------SH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESH--------QFIHRDLAARNCLVD-R-----DLCVKVSDFGMTRYV--------L--DDQY--------------VSSVGTKFPVKWSAPEVFH------YFKYSSKSDVWAFGILMWEVFSLGK--------------QP---------------YDLY-----DNSQVVLKV----SQGHR---LYRPHLAS------------------------------DTIYQ-IMYSCWHELPEKRPT-------FQ-QLLSS--I--------------
----YRLEKTLGKGQTGLVKLGVHC----------------ITGQKVAIKIV---NRE--KLSESV---L-MKVER-EIAILKLI--E---HPHVLKLHDVYE--N----------KKY--LYLVLEHVSGGELFDYLV--------KKG----------------------------------------------------------------------------------------------------RLTPKEARKFFRQIVSALDFCHSY--------SICHRDLKPENLLLD-E-----KNNIRIADFGMASL---------QVGDSLL--------------ET---SCGSPHYACPEVIK-----GEKYDGRRADMWSCGVILFALLV-GA--------------LP---------------FDDD--------NLRQLL----EKVKR---GVFHMPHFIP----------------------------PDCQS-LLRGMIEVEPEKRLS-------LE-QIQKHPW-Y-------------
----YRLEKTLGKGQTGLVKLGVHC----------------VTCQKVAIKIV---NRE--KLSESV---L-MKVER-EIAILKLI--E---HPHVLKLHDVYE--N----------KKY--LYLVLEHVSGGELFDYLV--------KKG----------------------------------------------------------------------------------------------------RLTPKEARKFFRQIISALDFCHSH--------SICHRDLKPENLLLD-E-----KNNIRIADFGMASL---------QVGDSLL--------------ET---SCGSPHYACPEVIR-----GEKYDGRKADVWSCGVILFALLV-GA--------------LP---------------FDDD--------NLRQLL----EKVKR---GVFHMPHFIP----------------------------PDCQS-LLRGMIEVDAARRLT-------LE-HIQKHIW-Y-------------
----LTFLKELGTGQFGVVKYGKWR-----------------GQYDVAIKMI---K-E--GSM-SE---D-EFI-E-EAKVMMNL--S---HEKLVQLYGVCT--K----------QRP--IFIITEYMANGCLLNYLR---------EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESK--------QFLHRDLAARNCLVN-D-----QGVVKVSDFGLSRYV--------L--DDEY--------------TSSVGSKFPVRWSPPEVLM------YSKFSSKSDIWAFGVLMWEIYSLGK--------------MP---------------YERF-----TNSETAEHI----AQGLR---LYRPHLAS------------------------------EKVYT-IMYSCWHEKADERPT-------FK-ILLSN--I--------------
---F-DIIGIIGEGTYGQVYKARDK----------------DTGEMVALKKV---RLD--NEKEGF---P-ITAIR-EIKILRQL--T---HQSIINMKEIVT--DKEDALDFKKDKGA--FYLVFEYMDH-DLMGLLE-------SGLV----------------------------------------------------------------------------------------------------HFNENHIKSFMRQLMEGLDYCHKK--------NFLHRDIKCSNILLN-N-----RGQIKLADFGLARLY-------SSEESRPY--------------TN---KVITLWYRPPELLL-----GEERYTPAIDVWSCGCILGELFT-KK--------------PI---------------FQAN-----QELAQLELI----SRICG---SPCPAVWPDVIKLPYFNTMKPKKQY-RRKLREEFVFIPAAALD-LFDYMLALDPSKRCT-------AE-QALQCEF-L-------------
----FQKVEKIGEGTYGVVYKARNK----------------LTGEVVALKKI---RLD--TETEGV---P-STAIR-EISLLKEL--N---HPNIVKLLDVIH--T----------ENK--LYLVFEFLHQ-DLKKFMDA------SALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH--------RVLHRDLKPQNLLIN-T-----EGAIKLADFGLARAF--------GVPVRTY--------------TH---EVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RR--------------AL---------------FPGD-----SEIDQLFRI----FRTLG---TPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-------AK-AALAHPFF--------------
----FQKVEKIGEGTYGVVYKAKNR----------------ETGQLVALKKI---RLD--LEMEGV---P-STAIR-EISLLKEL--K---HPNIVRLLDVVH--N----------ERK--LYLVFEFLSQ-DLKKYMDS------TPGS----------------------------------------------------------------------------------------------------ELPLHLIKSYLFQLLQGVSFCHSH--------RVIHRDLKPQNLLIN-E-----LGAIKLADFGLARAF--------GVPLRTY--------------TH---EVVTLWYRAPEILL-----GSKFYTTAVDIWSIGCIFAEMVT-RK--------------AL---------------FPGD-----SEIDQLFRI----FRMLG---TPSEDTWPGVTQLPDYKGSFPKWTR--KGLEEIVPNLEPEGRD-LLMQLLQYDPSQRIT-------AK-TALAHPYF--------------
----YEKLEKIGEGTYGTVFKAKNR----------------ETHEIVALKRV---RLD--DDDEGV---P-SSALR-EICLLKEL--K---HKNIVRLHDVLH--S----------DKK--LTLVFEFCDQ-DLKKYFD-------SCNG----------------------------------------------------------------------------------------------------DLDPEIVKSFLFQLLKGLGFCHSR--------NVLHRDLKPQNLLIN-R-----NGELKLADFGLARAF--------GIPVRCY--------------SA---EVVTLWYRPPDVLF-----GAKLYSTSIDMWSAGCIFAELANAGR--------------PL---------------FPGN-----DVDDQLKRI----FRLLG---TPTEEQWPSMTKLPDYKPYPMYPAT--TSLVNVVPKLNATGRD-LLQNLLKCNPVQRIS-------AE-EALQHPYF--------------
---W-DLVQTLGEGAYGEVQLAVNR----------------VTEEAVAVKIV---DMK--RAVDCP---E-NI-KK-EICINKML--N---HENVVKFYGHRR--E----------GNI--QYLFLEYCSGGELFDRIE--------PDI----------------------------------------------------------------------------------------------------GMPEPDAQRFFHQLMAGVVYLHGI--------GITHRDIKPENLLLD-E-----RDNLKISDFGLATVFR------YNNRERLL--------------NK---MCGTLPYVAPELLK-----RREFHAEPVDVWSCGIVLTAMLA-GE--------------LP---------------WDQP-------SDSCQEY----SDWKE---KKTYLNPWKKI--D------------------------SAPLA-LLHKILVENPSARIT-------IP-DIKKDRW-Y-------------
----LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAVKML---K-S--TAH-ADE-KE-ALM-S-ELKIMSHLG-Q---HENIVNLLGACT--H----------GGP--VLVITEYCCYGDLLNFLR---------RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASK--------NCIHRDVAARNVLLT-N-----GHVAKIGDFGLARDI----M---N--DSNY--------------IVKGNARLPVKWMAPESIF------DCVYTVQSDVWSYGILLWEIFSLGL--------------NP---------------YPGI-L---VNSKFYKLV----KDGYQ---MAQPAFAP------------------------------KNIYS-IMQACWALEPTHRPT-------FQ-QICSFL----------------
----LKLLQTIGKGEFGDVMLGDYR------------------GNKVAVKCI---K-N--DAT-AQ-----AFL-A-EASVMTQL--R---HSNLVQLLGVIV-EE----------KGG--LYIVTEYMAKGSLVDYLR---------SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGN--------NFVHRDLAARNVLVS-E-----DNVAKVSDFGLTKEA--------------S--------------STQDTGKLPVKWTAPEALR------EKKFSTKSDVWSFGILLWEIYSFGR--------------VP---------------YPRI-----PLKDVVPRV----EKGYK---MDAPDGCP------------------------------PAVYE-VMKNCWHLDAAMRPS-------FL-QLREQL----------------
----LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL---R-P--DAT-KNA-RN-DFL-K-EVKIMSRL--K---DPNIIRLLGVCV--Q----------DDP--LCMITDYMENGDLNQFLS---------AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATL--------NFVHRDLATRNCLVG-E-----NFTIKIADFGMSRNL----Y---A--GDYY--------------RVQGRAVLPIRWMAWECIL------MGKFTTASDVWAFGVTLWEVLMLCRA-------------QP---------------FGQL-----TDEQVIENAGEFFRDQGRQVYLSRPPACP------------------------------QGLYE-LMLRCWSRESEQRPP-------FS-QLHRFL----------------
---F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKIPVAIKEL---R-E--ATS-PKA-NK-EIL-D-EAYVMASV--D---NPHVCRLLGICL-------------TST--VQLITQLMPFGCLLDYVR---------EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR--------RLVHRDLAARNVLVK-T-----PQHVKITDFGLAKLL----G---A--EEKE--------------YHAEGGKVPIKWMALESIL------HRIYTHQSDVWSYGVTVWELMTFGS--------------KP---------------YDGI-----PASEISSIL----EKGER---LPQPPICT------------------------------IDVYM-IMVKCWMIDADSRPK-------FR-ELI----IEF------------
----IHIEKIIGSGDSGEVCYGRLR-------------VPGQRDVPVAIKAL---K-A--GYT-ERQ-RR-DFL-S-EASIMGQF--D---HPNIIRLEGVVT--R----------GRL--AMIVTEYMENGSLDTFLR---------TH--------------------------------------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSDL--------GYVHRDLAARNVLVD-S-----NLVCKVSDFGLSRVL----E---D--DPDA-------------AYTTTGGKIPIRWTAPEAIA------FRTFSSASDVWSFGVVMWEVLAYGE--------------RP---------------YWNM-----TNRDVISSV----EEGYR---LPAPMGCP------------------------------HALHQ-LMLDCWHKDRAQRPR-------FS-QIVSVL----------------
---V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREIYVAIKTL---K-A--GYS-EKQ-RR-DFL-S-EASIMGQF--D---HPNIIRLEGVVT--K----------SRP--VMIITEFMENGALDSFLR---------QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEM--------NYVHRDLAARNILVN-S-----NLVCKVSDFGLSRYLQ-DDT---S--DPTY--------------TSSLGGKIPVRWTAPEAIA------YRKFTSASDVWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDVINAI----EQDYR---LPPPMDCP------------------------------AALHQ-LMLDCWQKDRNSRPR-------FA-EIVNTL----------------
---V-KIEQVIGAGEFGEVCSGHLK-------------LPGKREIFVAIKTL---K-S--GYT-EKQ-RR-DFL-S-EASIMGQF--D---HPNVIHLEGVVT--K----------STP--VMIITEFMENGSLDSFLR---------QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADM--------NYVHRDLAARNILVN-S-----NLVCKVSDFGLSRFLE-DDT---S--DPTY--------------TSALGGKIPIRWTAPEAIQ------YRKFTSASDVWSYGIVMWEVMSYGE--------------RP---------------YWDM-----TNQDVINAI----EQDYR---LPPPMDCP------------------------------SALHQ-LMLDCWQKDRNHRPK-------FG-QIVNTL----------------
---V-KIEEVIGAGEFGEVCRGRLK-------------APGKKESCVAIKTL---K-G--GYT-ERQ-RR-EFL-S-EASIMGQF--E---HPNIIRLEGVVT--N----------SMP--VMILTEFMENGALDSFLR---------LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEM--------SYVHRDLAARNILVN-S-----NLVCKVSDFGLSRFLE-ENS---S--DPTY--------------TSSLGGKIPIRWTAPEAIA------FRKFTSASDAWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDVINAI----EQDYR---LPPPPDCP------------------------------TSLHQ-LMLDCWQKDRNARPR-------FP-QVVSAL----------------
----IKIEEVIGTGSFGEVRQGRLQ-------------PRGRREQTVAIQAL---W-A--GGA-ESL-QM-TFL-G-RAAVLGQF--Q---HPNILRLEGVVT--K----------SRP--LMVLTEFMELGPLDSFLR---------QR--------------------------------------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSF--------AFVHRSLSAHSVLVN-S-----HLVCKVARLGHSPQG----------------------------------PSCLLRWAAPEVIA------HGKHTTSSDVWSFGILMWEVMSYGE--------------RP---------------YWDM-----SEQEVLNAI----EQEFR---LPPPPGCP------------------------------PGLHL-LMLDTWQKDRARRPH-------FD-QLVA---AF-------------
---L-RKVKVLGSGAFGTVYKGIWIP------------DGENVKIPVAIKVL---R-E--NTS-PKA-NK-EIL-D-EAYVMAGV--G---SPYVSRLLGICL-------------TST--VQLVTQLMPYGCLLDHVR---------EN--------------------------------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLEDV--------RLVHRDLAARNVLVK-S-----PNHVKITDFGLARLL----D---I--DETE--------------YHADGGKVPIKWMALESIL------RRRFTHQSDVWSYGVTVWELMTFGA--------------KP---------------YDGI-----PAREIPDLL----EKGER---LPQPPICT------------------------------IDVYM-IMVKCWMIDSECRPR-------FR-ELVSE--F--------------
---L-KRVKVLGSGAFGTVYKGIWVP------------EGETVKIPVAIKIL---N-E--TTG-PKA-NV-EFM-D-EALIMASM--D---HPHLVRLLGVCL-------------SPT--IQLVTQLMPHGCLLEYVH---------EH--------------------------------------------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEER--------RLVHRDLAARNVLVK-S-----PNHVKITDFGLARLL----E---G--DEKE--------------YNADGGKMPIKWMALECIH------YRKFTHQSDVWSYGVTIWELMTFGG--------------KP---------------YDGI-----PTREIPDLL----EKGER---LPQPPICT------------------------------IDVYM-VMVKCWMIDADSRPK-------FK-ELAAE--F--------------
--VI--LGELLGKGNFGEVYKGTLK-----------------DKTSVAVKTC---K-E--DLP-QEL-KI-KFL-Q-EAKILKQY--D---HPNIVKLIGVCT--Q----------RQP--VYIIMELVSGGDFLTFLR---------RK--------------------------------------------------------------------------------------------------KDELKLKQLVKFSLDAAAGMLYLESK--------NCIHRDLAARNCLVG-E-----NNVLKISDFGMSRQE--------D--GGVY--------------SSSGLKQIPIKWTAPEALN------YGRYSSESDVWSFGILLWETFSLGV--------------CP---------------YPGM-----TNQQAREQV----ERGYR---MSAPQHCP------------------------------EDISK-IMMKCWDYKPENRPK-------FS-ELQKEL----------------
---L-VLGEQIGRGNFGEVFSGRLR----------------ADNTLVAVKSC---R-E--TLP-PDL-KA-KFL-Q-EARILKQY--S---HPNIVRLIGVCT--Q----------KQP--IYIVMELVQGGDFLTFLR---------TE--------------------------------------------------------------------------------------------------GARLRVKTLLQMVGDAAAGMEYLESK--------CCIHRDLAARNCLVT-E-----KNVLKISDFGMSREE----A---D--GVYA--------------ASGGLRQVPVKWTAPEALN------YGRYSSESDVWSFGILLWETFSLGA--------------SP---------------YPNL-----SNQQTREFV----EKGGR---LPCPELCP------------------------------DAVFR-LMEQCWAYEPGQRPS-------FS-TIYQEL----------------
---L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKML---K-S--DAT-EKD-LS-DLI-S-EMEMMKMIG-K---HKNIINLLGACT--Q----------DGP--LYVIVEYASKGNLREYLQ---------ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--------KCIHRDLAARNVLVT-E-----DNVMKIADFGLARDI----H---H--IDYY--------------KKTTNGRLPVKWMAPEALF------DRIYTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGV-----PVEELFKLL----KEGHR---MDKPSNCT------------------------------NELYM-MMRDCWHAVPSQRPT-------FK-QLVEDL----------------
----LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAVKML---K-D--DAT-EKD-LS-DLV-S-EMEMMKMIG-K---HKNIINLLGACT--Q----------DGP--LYVIVEYASKGNLREYLR---------ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ--------KCIHRDLAARNVLVT-E-----NNVMKIADFGLARDI----N---N--IDYY--------------KKTTNGRLPVKWMAPEALF------DRVYTHQSDVWSFGVLMWEIFTLGG--------------SP---------------YPGI-----PVEELFKLL----KEGHR---MDKPANCT------------------------------NELYM-MMRDCWHAVPSQRPT-------FK-QLVEDL----------------
----LTLGKPLGEGCFGQVVMAEAIGI---------DKDRAAKPVTVAVKML---K-D--DAT-DKD-LS-DLV-S-EMEMMKMIG-K---HKNIINLLGACT--Q----------GGP--LYVLVEYAAKGNLREFLR---------ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQ--------KCIHRDLAARNVLVT-E-----DNVMKIADFGLARDV----H---N--LDYY--------------KKTTNGRLPVKWMAPEALF------DRVYTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGI-----PVEELFKLL----KEGHR---MDKPANCT------------------------------HDLYM-IMRECWHAAPSQRPT-------FK-QLVEDL----------------
---L-VLGKPLGEGCFGQVVRAEAFGM---------DPARPDQASTVAVKML---K-D--NAS-DKD-LA-DLV-S-EMEVMKLIG-R---HKNIINLLGVCT--Q----------EGP--LYVIVECAAKGNLREFLR---------ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESR--------KCIHRDLAARNVLVT-E-----DNVMKIADFGLARGV----H---H--IDYY--------------KKTSNGRLPVKWMAPEALF------DRVYTHQSDVWSFGILLWEIFTLGG--------------SP---------------YPGI-----PVEELFSLL----REGHR---MDRPPHCP------------------------------PELYG-LMRECWHAAPSQRPT-------FK-QLVEAL----------------
----IQLLKRLGSGQFGEVWEGLWN-----------------NTTPVAVKTL---K-P--GSM-DP---N-DFL-R-EAQIMKNL--R---HPKLIQLYAVCT--L----------EDP--IYIITELMRHGSLQEYLQ---------ND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESR--------NYIHRDLAARNVLVG-E-----HNIYKVADFGLARVFK--VD---N--EDIY--------------ESRHEIKLPVKWTAPEAIR------SNKFSIKSDVWSFGILLYEIITYGK--------------MP---------------YSGM-----TGAQVIQML----AQNYR---LPQPSNCP------------------------------QQFYN-IMLECWNAEPKERPT-------FE-TLRWK--L--------------
----LQLIKRLGNGQFGEVWMGTWN-----------------GNTKVAIKTL---K-P--GTM-SP---E-SFL-E-EAQIMKKL--K---HDKLVQLYAVVS-------------EEP--IYIVTEYMNKGSLLDFLK---------DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERM--------NYIHRDLRSANILVG-N-----GLICKIADFGLARLI--------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELVTKGR--------------VP---------------YPGM-----NNREVLEQV----ERGYR---MPCPQDCP------------------------------ISLHE-LMIHCWKKDPEERPT-------FE-YLQSFL----------------
----LKLEKKLGAGQFGEVWMATYN-----------------KHTKVAVKTM---K-P--GSM-SV---E-AFL-A-EANVMKTL--Q---HDKLVKLHAVVT-------------KEP--IYIITEFMAKGSLLDFLK---------SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR--------NYIHRDLRAANILVS-A-----SLVCKIADFGLARVI--------E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGSFTIKSDVWSFGILLMEIVTYGR--------------IP---------------YPGM-----SNPEVIRAL----ERGYR---MPRPENCP------------------------------EELYN-IMMRCWKNRPEERPT-------FE-YIQSV--L--------------
----YTTIRQLGDGTYGSVLLGRSI----------------ESGELIAIKKM---KRK--FYSWEE---C--MNLR-EVKSLKKL--N---HANVVKLKEVIR--E----------NDH--LYFIFEYMKE-NLYQLIK-------ERNK----------------------------------------------------------------------------------------------------LFPESAIRNIMYQILQGLAFIHKH--------GFFHRDLKPENLLCM-G-----PELVKIADFGLARE---------IRSKPPY--------------TD---YVSTRWYRAPEVLL-----RSTNYSSPIDVWAVGCIMAEVYT-LR--------------PL---------------FPGA-----SEIDTIFKI----CQVLG---TPKKTDWPEGYQLSSAMNFRWPQCV-PNNLKTLIPNASSEAVQ-LLRDMLQWDPKKRPT-------AS-QALRYPYF--------------
----ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAVKTV---N-E--SAS-LRE-RI-EFL-N-EASVMKGF--T---CHHVVRLLGVVS--K----------GQP--TLVVMELMAHGDLKSYLR---------SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK--------KFVHRDLAARNCMVA-H-----DFTVKIGDFGMTRDI----Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK------DGVFTTSSDMWSFGVVLWEITSLAE--------------QP---------------YQGL-----SNEQVLKFV----MDGGY---LDQPDNCP------------------------------ERVTD-LMRMCWQFNPKMRPT-------FL-EIVNLL----------------
-VGG----NKMGEGGFGVVYKGYVN----------------NTT--VAVKKL---AAM--VDITTE---ELKQQFDQEIKVMAKC--Q---HENLVELLGFSS--D----------GDD--LCLVYVYMPNGSLLDRLSC-----LDGTP----------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN--------HHIHRDIKSANILLD-E-----AFTAKISDFGLARASE------KFAQTVMT--------------SR---IVGTTAYMAPEALR-------GEITPKSDIYSFGVVLLEIIT-GL--------------PA---------------VDEH-----REPQLLLDI----KEEIE---DEEKTIEDYIDKKMNDAD----------------STSVEAMYS-VASQCLHEKKNKRPD-------IK-KVQQ----LLQ-----------
----LTFVQEIGSGQFGLVHLGYWL-----------------NKDKVAIKTI---R-E--GAM-SE---E-DFI-E-EAEVMMKL--S---HPKLVQLYGVCL--E----------QAP--ICLVFEFMEHGCLSDYLR---------TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEA--------CVIHRDLAARNCLVG-E-----NQVIKVSDFGMTRFV--------L--DDQY--------------TSSTGTKFPVKWASPEVFS------FSRYSSKSDVWSFGVLMWEVFSEGK--------------IP---------------YENR-----SNSEVVEDI----STGFR---LYKPRLAS------------------------------THVYQ-IMNHCWKERPEDRPA-------FS-RLLRQL----------------
---L-KRIRDLGEGHFGKVELCRYDP------------EGDNTGEQVAVKSL---K-P--ESG-GNH-IA-DLK-K-EIEILRNL--Y---HENIVKYKGICT-ED-----------GGNGIKLIMEFLPSGSLKEYLP---------KN--------------------------------------------------------------------------------------------------KNKINLKQQLKYAVQICKGMDYLGSR--------QYVHRDLAARNVLVE-S-----EHQVKIGDFGLTKAI---ET---D--KEYY--------------TVKDDRDSPVFWYAPECLM------QSKFYIASDVWSFGVTLHELLTYCD--------------SDSSPMALF-LKMIGPTHGQM-----TVTRLVNTL----KEGKR---LPCPPNCP------------------------------DEVYQ-LMRKCWEFQPSNRTS-------FQ-NLIE---GF-------------
----LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAVKKL---Q-H--STE--EH-LR-DFE-R-EIEILKSL--Q---HDNIVKYKGVCYSAG----------RRN--LKLIMEYLPYGSLRDYLQ---------KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK--------RYIHRDLATRNILVE-N-----ENRVKIGDFGLTKVL---PQ---D--KEYY--------------KVKEPGESPIFWYAPESLT------ESKFSVASDVWSFGVVLYELFTYIE--------------KSKSPPAEFMRMIGNDKQGQM-----IVFHLIELL----KNNGR---LPRPDGCP------------------------------DEIYM-IMTECWNNNVNQRPS-------FR-DLA----LRV------------
---L-KYISQLGKGNFGSVELCRYDP------------LGDNTGALVAVKQL---Q-H--SGP-DQ--QR-DFQ-R-EIQILKAL--H---SDFIVKYRGVSYGPG----------RQS--LRLVMEYLPSGCLRDFLQ---------RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSR--------RCVHRDLAARNILVE-S-----EAHVKIADFGLAKLL---PL---D--KDYY--------------VVREPGQSPIFWYAPESLS------DNIFSRQSDVWSFGVVLYELFTYCD--------------KSCSPSAE--FLRMMGCERDV-P---ALCRLLELL----EEGQR---LPAPPACP------------------------------AEVHE-LMKLCWAPSPQDRPS-------FS-ALGP---QL-------------
----YEIDRTIGKGNFAVVKRATHL----------------VTKAKVAIKII---DKT--QLDEEN---L-KKIFR-EVQIMKML--C---HPHIIRLYQVME--T----------ERM--IYLVTEYASGGEIFDHLV--------AHG----------------------------------------------------------------------------------------------------RMAEKEARRKFKQIVTAVYFCHCR--------NIVHRDLKAENLLLD-A-----NLNIKIADFGFSNL---------FTPGQLL--------------KT---WCGSPPYAAPELFE-----GKEYDGPKVDIWSLGVVLYVLVC-GA--------------LP---------------FDGS--------TLQNLR----ARVLS---GKFRIPFFMS----------------------------TECEH-LIRHMLVLDPNKRLS-------ME-QICKHKWM--------------
----LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAVKML---K-P--SAH-LTE-RE-ALM-S-ELKVLSYLG-N---HMNIVNLLGACT--I----------GGP--TLVITEYCCYGDLLNFLR---------RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK--------NCIHRDLAARNILLT-H-----GRITKICDFGLARDI----K---N--DSNY--------------VVKGNARLPVKWMAPESIF------NCVYTFESDVWSYGIFLWELFSLGS--------------SP---------------YPGM-P---VDSKFYKMI----KEGFR---MLSPEHAP------------------------------AEMYD-IMKTCWDADPLKRPT-------FK-QIVQL--I--------------
----LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSL---K-Q--GSM-SP---D-AFL-A-EANLMKQL--Q---HQRLVRLYAVVT-------------QEP--IYIITEYMENGSLVDFLK---------TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVS-D-----TLSCKIADFGLARLI--------E--DNEY--------------TAREGAKFPIKWTAPEAIN------YGTFTIKSDVWSFGILLTEIVTHGR--------------IP---------------YPGM-----TNPEVIQNL----ERGYR---MVRPDNCP------------------------------EELYQ-LMRLCWKERPEDRPT-------FD-YLRSV--L--------------
---V-TLLRALGHGAFGEVYEGLVIG-----------LPGDSSPLQVAIKTL---P-E--LCS-PQD-EL-DFL-M-EALIISKF--R---HQNIVRCVGLSL--R----------ATP--RLILLELMSGGDMKSFLR---------HSRP--------------------------------------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEEN--------HFIHRDIAARNCLLS-CA--GPSRVAKIGDFGMARDI----Y---R--ASYY--------------RRGDRALLPVKWMPPEAFL------EGIFTSKTDSWSFGVLLWEIFSLGY--------------MP---------------YPGR-----TNQEVLDFV----VGGGR---MDPPRGCP------------------------------GPVYR-IMTQCWQHEPELRPS-------FA-SILERL----------------
----IKLVKRLGAGQFGEVWMGYYN-----------------NSTKVAVKTL---K-P--GTM-SV---Q-AFL-E-EANLMKTL--Q---HDKLVRLYAVVT--R----------EEP--IYIITEYMAKGSLLDFLK---------SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERK--------NYIHRDLRAANVLVS-E-----SLMCKIADFGLARVI--------E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGCFTIKSDVWSFGILLYEIVTYGK--------------IP---------------YPGR-----TNADVMTAL----SQGYR---MPRVENCP------------------------------DELYD-IMKMCWKEKAEERPT-------FD-YLQSV--L--------------
----YTTMRQLGDGTYGSVLMGKSN----------------ESGELVAIKRM---KRK--FYSWDE---C-M-NLR-EVKSLKKL--N---HANVIKLKEVIR--E----------NDH--LYFIFEYMKE-NLYQLMK-------DRNK----------------------------------------------------------------------------------------------------LFPESVIRNIMYQILQGLAFIHKH--------GFFHRDMKPENLLCM-G-----PELVKIADFGLARE---------LRSQPPY--------------TD---YVSTRWYRAPEVLL-----RSSVYSSPIDVWAVGSIMAELYM-LR--------------PL---------------FPGT-----SEVDEIFKI----CQVLG---TPKKSDWPEGYQLASSMNFRFPQCV-PINLKTLIPNASNEAIQ-LMTEMLNWDPKKRPT-------AS-QALKHPYF--------------
----YTNLSYIGEGAYGMVCSAYDN----------------VNKVRVAIKKI---SPF--EHQTYC---Q-RT-LR-EIKILLRF--R---HENIIGINDIIR--APT-----IEQMKD--VYIVQDLMET-DLYKLLK---------TQ----------------------------------------------------------------------------------------------------HLSNDHICYFLYQILRGLKYIHSA--------NVLHRDLKPSNLLLN-T-----TCDLKICDFGLARVAD-----PDHDHTGFL--------------TE---YVATRWYRAPEIML-----NSKGYTKSIDIWSVGCILAEMLS-NR--------------PI---------------FPGK-----HYLDQLNHI----LGILG---SPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALD-LLDKMLTFNPHKRIE-------VE-QALAHPYL--------------
----YQNLSPVGSGAYGSVCAAFDT----------------KTGLRVAVKKL---SRP--FQSIIH---A-KRTYR-ELRLLKHM--K---HENVIGLLDVFT--PARS----LEEFND--VYLVTHLMGA-DLNNIVK---------CQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSA--------DIIHRDLKPSNLAVN-E-----DCELKILDFGLAR-----------HTDDEM--------------TG---YVATRWYRAPEIML-----NWMHYNQTVDIWSVGCIMAELLT-GR--------------TL---------------FPGT-----DHIDQLKLI----LRLVG---TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVD-LLEKMLVLDSDKRIT-------AA-QALAHAYF--------------
----YRLLKTIGKGNFAKVKLARHI----------------LTGKEVAVKII---DKT--QLNSSS---L-QKLFR-EVRIMKVL--N---HPNIVKLFEVIE--T----------EKT--LYLVMEYASGGEVFDYLV--------AHG----------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVQYCHQK--------FIVHRDLKAENLLLD-A-----DMNIKIADFGFSNE---------FTFGNKL--------------DT---FCGSPPYAAPELFQ-----GKKYDGPEVDVWSLGVILYTLVS-GS--------------LP---------------FDGQ--------NLKELR----ERVLR---GKYRIPFYMS----------------------------TDCEN-LLKKFLILNPSKRGT-------LE-QIMKDRWM--------------
----YRLLRTIGKGNFAKVKLARHI----------------LTGREVAIKII---DKT--QLNPSS---L-QKLFR-EVRIMKGL--N---HPNIVKLFEVIE--T----------EKT--LYLVMEYASAGEVFDYLV--------SHG----------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVHYCHQK--------NIVHRDLKAENLLLD-A-----EANIKIADFGFSNE---------FTLGSKL--------------DT---FCGSPPYAAPELFQ-----GKKYDGPEVDIWSLGVILYTLVS-GS--------------LP---------------FDGH--------NLKELR----ERVLR---GKYRVPFYMS----------------------------TDCES-ILRRFLVLNPAKRCT-------LE-QIMKDKWI--------------
----LTLGAQIGEGEFGAVLQGEYL------------------GQKVAVKNI---K-C--DVT-AQ-----AFL-D-ETAVMTKM--Q---HENLVRLLGVIL-------------HQG--LYIVMEHVSKGNLVNFLR---------TR-------------------------------------------------------------------------------------------------GRALVNTAQLLQFSLHVAEGMEYLESK--------KLVHRDLAARNILVS-E-----DLVAKVSDFGLAKAE--------------R--------------KGLDSSRLPVKWTAPEALK------HGKFTSKSDVWSFGVLLWEVFSYGR--------------AP---------------YPKM-----SLKEVSEAV----EKGYR---MEPPEGCP------------------------------GPVHV-LMSSCWEAEPARRPP-------FR-KLAEKL----------------
----YRIRGEIGSGNFSQVKLGIHS----------------LTKEKVAIKIL---DKT--KLDQKT---Q-RLLSR-EISSMEKL--H---HPNIIRLYEVVE--T----------LSK--LHLVMEYAGGGELFGKIS--------TEG----------------------------------------------------------------------------------------------------KLSEPESKLIFSQIVSAVKHMHEN--------QIIHRDLKAENVFYT-S-----NTCVKVGDFGFSTV---------SKKGEML--------------NT---FCGSPPYAAPELFR-----DEHYIGIYVDIWALGVLLYFMVT-GT--------------MP---------------FRAE--------TVAKLK----KSILE---GTYSVPPHV----S------------------------EPCHR-LIRGVLQQIPTERYG-------ID-CIMNDEWM--------------
---I-EYVRDIGEGAFGRVFQARAPG-----------LLPYEPFTMVAVKML---K-E--EAS-ADM-QA-DFQ-R-EAALMAEF--D---NPNIVKLLGVCA--V----------GKP--MCLLFEYMAYGDLNEFLR---------SMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSER--------KFVHRDLATRNCLVG-E-----NMVVKIADFGLSRNI----Y---S--ADYY--------------KANENDAIPIRWMPPESIF------YNRYTTESDVWAYGVVLWEIFSYGL--------------QP---------------YYGM-----AHEEVIYYV----RDGNI---LSCPENCP------------------------------VELYN-LMRLCWSKLPADRPS-------FT-SIHRIL----------------
---I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKILVAVKTL---K-D--ASD-NA--RK-DFH-R-EAELLTNL--Q---HEHIVKFYGVCV--E----------GDP--LIMVFEYMKHGDLNKFLR---------AHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQ--------HFVHRDLATRNCLVG-E-----NLLVKIGDFGMSRDV----Y---S--TDYY--------------RVGGHTMLPIRWMPPESIM------YRKFTTESDVWSLGVVLWEIFTYGK--------------QP---------------WYQL-----SNNEVIECI----TQGRV---LQRPRTCP------------------------------QEVYE-LMLGCWQREPHMRKN-------IK-GIHTL--L--------------
---I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKMLVAVKAL---K-D--PTL-AA--RK-DFQ-R-EAELLTNL--Q---HEHIVKFYGVCG--D----------GDP--LIMVFEYMKHGDLNKFLR---------AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQ--------HFVHRDLATRNCLVG-A-----NLLVKIGDFGMSRDV----Y---S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM------YRKFTTESDVWSFGVILWEIFTYGK--------------QP---------------WFQL-----SNTEVIECI----TQGRV---LERPRVCP------------------------------KEVYD-VMLGCWQREPQQRLN-------IK-EIYKIL----------------
----YELQETLGKGTYGKVKRATER----------------FSGRVVAIKSI---RKD--KIKDEQ---D-MVHIRREIEIMSSL--N---HPHIISIYEVFE--N----------KDK--IVIIMEYASKGELYDYIS--------ERR----------------------------------------------------------------------------------------------------RLSERETRHFFRQIVSAVHYCHKN--------GVVHRDLKLENILLD-D-----NCNIKIADFGLSNL---------YQKDKFL--------------QT---FCGSPLYASPEIVN-----GRPYRGPEVDSWALGVLLYTLVY-GT--------------MP---------------FDGF--------DHKNLI----RQISS---GEYREPTQP-----------------------------SDARG-LIRWMLMVNPDRRAT-------IE-DIANHWW-V-------------
----YEFLETLGKGTYGKVKKARES----------------SGR-LVAIKSI---RKD--KIKDEQ---D-LMHIRREIEIMSSL--N---HPHIIAIHEVFE--N----------SSK--IVIVMEYASRGDLYDYIS--------ERQ----------------------------------------------------------------------------------------------------QLSEREARHFFRQIVSAVHYCHQN--------RVVHRDLKLENILLD-A-----NGNIKIADFGLSNL---------YHQGKFL--------------QT---FCGSPLYASPEIVN-----GKPYTGPEVDSWSLGVLLYILVH-GT--------------MP---------------FDGH--------DHKILV----KQISN---GAYREPPK-----P------------------------SDACG-LIRWLLMVNPTRRAT-------LE-DVASHWW-V-------------
----YELQEVIGSGATAVVQAAYCA----------------PKKEKVAIKRI---NLE--KCQTSM---D-E-LLK-EIQAMSQC--H---HPNIVSYYTSFV--V----------KDE--LWLVMKLLSGGSVLDIIKHIVAKGEHKSG----------------------------------------------------------------------------------------------------VLDESTIATILREVLEGLEYLHKN--------GQIHRDVKAGNILLG-E-----DGSVQIADFGVSAFLAT---GGDITRNKVR--------------KT---FVGTPCWMAPEVME-----QVRGYDFKADIWSFGITAIELAT-GA--------------AP---------------YHKY-----PPMKVLMLT----LQNDP---PSLETGVQDKE--MLK-------------------KYGKSFRK-MISLCLQKDPEKRPT-------AA-ELLRHKFF--------------
---L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAVKML---K-P--TAR-SSE-KQ-ALM-S-ELKIMTHLG-P---HLNIVNLLGACT--K----------SGP--IYIITEYCFYGDLVNYLH---------KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASK--------NCVHRDLAARNVLLA-Q-----GKIVKICDFGLARDI----M---H--DSNY--------------VSKGSTFLPVKWMAPESIF------DNLYTTLSDVWSYGILLWEIFSLGG--------------TP---------------YPGM-M---VDSTFYNKI----KSGYR---MAKPDHAT------------------------------SEVYE-IMVKCWNSEPEKRPS-------FY-HLSE---IV-------------
---L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAVKML---K-S--TAR-SSE-KQ-ALM-S-ELKIMSHLG-P---HLNVVNLLGACT--K----------GGP--IYIITEYCRYGDLVDYLH---------RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASK--------NCVHRDLAARNVLIC-E-----GKLVKICDFGLARDI----M---R--DSNY--------------ISKGSTFLPLKWMAPESIF------NSLYTTLSDVWSFGILLWEIFTLGG--------------TP---------------YPEL-P---MNEQFYNAI----KRGYR---MAQPAHAS------------------------------DEIYE-IMQKCWEEKFEIRPP-------FS-QLVL---LL-------------
---F-KFLAVLGRGHFGKVLLSEFR----------------PSGELFAIKAL---KKG--DIVARD---E-VESLMCEKRILAAV--TSAGHPFLVNLFGCFQ--T----------PEH--VCFVMEYSAGGDLMLHIH---------SD----------------------------------------------------------------------------------------------------VFSEPRAIFYSACVVLGLQFLHEH--------KIVYRDLKLDNLLLD-T-----EGYVKIADFGLCKEG--------MGYGDRT--------------ST---FCGTPEFLAPEVLT------DTSYTRAVDWWGLGVLLYEMLV-GE--------------SP---------------FPGD--------DEEEVF----DSIVN---DEVRYPRFLS----------------------------AEAIG-IMRRLLRRNPERRLGSS--ERDAE-DVKKQPFF--------------
--FR--CCAVLGRGHFGKVLLAEYK----------------NTNEMFAIKAL---KKG--DIVARD---E-VDSLMCEKRIFETV--NSVRHPFLVNLFACFQ--T----------KEH--VCFVMEYAAGGDLMMHIH---------TD----------------------------------------------------------------------------------------------------VFSEPRAVFYAACVVLGLQYLHEH--------KIVYRDLKLDNLLLD-T-----EGFVKIADFGLCKEG--------MGYGDRT--------------ST---FCGTPEFLAPEVLT------ETSYTRAVDWWGLGVLIYEMLV-GE--------------SP---------------FPGD--------DEEEVF----DSIVN---DEVRYPRFLS----------------------------TEAIS-IMRRLLRRNPERRLGAS--EKDAE-DVKKHPFF--------------
---F-NFLMVLGKGSFGKVMLADRK----------------GTEELYAIKIL---KKD--VVIQDD---D-VECTMVEKRVLALL-DK---PPFLTQLHSCFQ--T----------VDR--LYFVMEYVNGGDLMYHIQ--------QVG----------------------------------------------------------------------------------------------------KFKEPQAVFYAAEISIGLFFLHKR--------GIIYRDLKLDNVMLD-S-----EGHIKIADFGMCKEH--------MMDGVTT--------------RT---FCGTPDYIAPEIIA------YQPYGKSVDWWAYGVLLYEMLA-GQ--------------PP---------------FDGE--------DEDELF----QSIME---HNVSYPKSLS----------------------------KEAVS-VCKGLMTKHPAKRLG-------C----------GPEGERDVREHAFF
--FI--FHKVLGKGSFGKVLLGELK----------------GRGEYFAIKAL---KKD--VVLIDD---D-VECTMVEKRVLTLA-AE---NPFLTHLICTFQ--T----------KDH--LFFVMEFLNGGDLMYHIQ--------DKG----------------------------------------------------------------------------------------------------RFELYRATFYAAEIMCGLQFLHSK--------GIIYRDLKLDNVLLD-R-----DGHIKIADFGMCKEN--------IFGESRA--------------ST---FCGTPDYIAPEILQ------GLKYTFSVDWWSFGVLLYEMLI-GQ--------------SP---------------FHGD--------DEDELF----ESIRV---DTPHYPRWIT----------------------------KESKD-ILEKLFEREPTKRLG------VTG-NIKIHPFF--------------
---F-NFIKVLGKGSFGKVMLAELK----------------GKDEVYAVKVL---KKD--VILQDD---D-VDCTMTEKRILALA-RK---HPYLTQLYCCFQ--T----------KDR--LFFVMEYVNGGDLMFQIQ--------RSR----------------------------------------------------------------------------------------------------KFDEPRSRFYAAEVTSALMFLHQH--------GVIYRDLKLDNILLD-A-----EGHCKLADFGMCKEG--------ILNGVTT--------------TT---FCGTPDYIAPEILQ------ELEYGPSVDWWALGVLMYEMMA-GQ--------------PP---------------FEAD--------NEDDLF----ESILH---DDVLYPVWLS----------------------------KEAVS-ILKAFMTKNPHKRLGCVASQNGED-AIKQHP--FF------------
--FI--LHKMLGKGSFGKVFLAEFK----------------KTNQFFAIKAL---KKD--VVLMDD---D-VECTMVEKRVLSLA-WE---HPFLTHMFCTFQ--T----------KEN--LFFVMEYLNGGDLMYHIQ--------SCH----------------------------------------------------------------------------------------------------KFDLSRATFYAAEIILGLQFLHSK--------GIVYRDLKLDNILLD-K-----DGHIKIADFGMCKEN--------MLGDAKT--------------NT---FCGTPDYIAPEILL------GQKYNHSVDWWSFGVLLYEMLI-GQ--------------SP---------------FHGQ--------DEEELF----HSIRM---DNPFYPRWLE----------------------------KEAKD-LLVKLFVREPEKRLG-------VRGDIRQHPLF--------------
---F-TLCRKLGSGYFGEVFEGLWK-----------------DRVQVAIKVI---S-R--DNL-LH--QQ-MLQ-S-EIQAMKKL--R---HKHILALYAVVS--V----------GDP--VYIITELMAKGSLLELLR---------DS-------------------------------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQ--------NYIHRDLAARNILVG-E-----NTLCKVGDFGLARLI-----------KEDV--------------YLSHDHNIPYKWTAPEALS------RGHYSTKSDVWSFGILLHEMFSRGQ--------------VP---------------YPGM-----SNHEAFLRV----DAGYR---MPCPLECP------------------------------PSVHK-LMLTCWCRDPEQRPC-------FK-ALRERL----------------
---L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYTTVAVKML---K-E--NAS-PSE-LR-DLL-S-EFNVLKQV--N---HPHVIKLYGACS--Q----------DGP--LLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM--------KLVHRDLAARNILVA-E-----GRKMKISDFGLSRDV----Y---E--EDSY--------------VKRSQGRIPVKWMAIESLF------DHIYTTQSDVWSFGVLLWEIVTLGG--------------NP---------------YPGI-----PPERLFNLL----KTGHR---MERPDNCS------------------------------EEMYR-LMLQCWKQEPDKRPV-------FA-DISKDL----------------
--LT--LRLLLGSGAFGEVYEGTAVDI----------LGVGSGEIKVAVKTL---K-K--GST-DQE-KI-EFL-K-EAHLMSKF--N---HPNILKQLGVCL--L----------NEP--QYIILELMEGGDLLTYLR---------KARM--------------------------------------------------------------------------------------------ATFYGPLLTLVDLVDLCVDISKGCVYLERM--------HFIHRDLAARNCLVS-VKDYTSPRIVKIGDFGLARDI----Y---K--NDYY--------------RKRGEGLLPVRWMAPESLM------DGIFTTQSDVWSFGILIWEILTLGH--------------QP---------------YPAH-----SNLDVLNYV----QTGGR---LEPPRNCP------------------------------DDLWN-LMTQCWAQEPDQRPT-------FH-RIQDQL----------------
----YDIERTLGKGNFAVVKLARHR----------------VTKTQVAIKII---DKT--RLDSSN---L-EKIYR-EVQLMKLL--N---HPHIIKLYQVME--T----------KDM--LYIVTEFAKNGEMFDYLT--------SNG----------------------------------------------------------------------------------------------------HLSENEARKKFWQILSAVEYCHDH--------HIVHRDLKTENLLLD-G-----NMDIKLADFGFGNF---------YKSGEPL--------------ST---WCGSPPYAAPEVFE-----GKEYEGPQLDIWSLGVVLYVLVC-GS--------------LP---------------FDGP--------NLPTLR----QRVLE---GRFRIPFFMS----------------------------QDCES-LIRRMLVVDPARRIT-------IA-QIRQHRWM--------------
----YDIEGTLGKGNFAVVKLGRHR----------------ITKTEVAIKII---DKS--QLDAVN---L-EKIYR-EVQIMKML--D---HPHIIKLYQVME--T----------KSM--LYLVTEYAKNGEIFDYLA--------NHG----------------------------------------------------------------------------------------------------RLNESEARRKFWQILSAVDYCHGR--------KIVHRDLKAENLLLD-N-----NMNIKIADFGFGNF---------FKSGELL--------------AT---WCGSPPYAAPEVFE-----GQQYEGPQLDIWSMGVVLYVLVC-GA--------------LP---------------FDGP--------TLPILR----QRVLE---GRFRIPYFMS----------------------------EDCEH-LIRRMLVLDPSKRLT-------IA-QIKEHKWM--------------
----YDLDKTLGRGHFAVVKLARHV----------------FTGEKVAVKVI---DKT--KLDTLA---T-GHLFQ-EVRCMKLV--Q---HPNIVRLYEVID--T----------QTK--LYLILELGDGGDMFDYIM-------KHEE----------------------------------------------------------------------------------------------------GLNEDLAKKYFAQIVHAISYCHKL--------HVVHRDLKPENVVFFEK-----QGLVKLTDFGFSNK---------FQPGKKL--------------TT---SCGSLAYSAPEILL-----GDEYDAPAVDIWSLGVILFMLVC-GQ--------------PP---------------FQEA--------NDSETL----TMIMD---CKYTVPSHVS----------------------------KECKD-LITRMLQRDPKRRAS-------LE-EIENHPWL--------------
---L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAIKTL---K-P--GTM-SP---E-AFL-Q-EAQVMKKL--R---HEKLVQLYAVVS-------------EEP--IYIVTEYMSKGSLLDFLK---------GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVG-E-----NLVCKVADFGLARLI--------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELTTKGR--------------VP---------------YPGM-----VNREVLDQV----ERGYR---MPCPPECP------------------------------ESLHD-LMCQCWRKEPEERPT-------FE-YLQAF--L--------------
--FA--LGRKLGEGYFGEVWEGLWL-----------------GSLPVAIKVI---K-S--ANM-K---LT-DLA-K-EIQTLKGL--R---HERLIRLHAVCS--G----------GEP--VYIVTELMRKGNLQAFLG---------TP-------------------------------------------------------------------------------------------------EGRALRLPPLLGFACQVAEGMSYLEEQ--------RVVHRDLAARNVLVD-D-----GLACKVADFGLARLL--------K--DDIY--------------SPSSSSKIPVKWTAPEAAN------YRVFSQKSDVWSFGVLLHEVFTYGQ--------------CP---------------YEGM-----TNHETLQQI----MRGYR---LPRPAACP------------------------------AEVYV-LMLECWRSSPEERPS-------FA-TLREKL----------------
----FTKLEKIGKGSFGEVFKGIDN----------------RTQKVVAIKII---DLE--EAEDEI---E-DIQ-Q-EITVLSQC--D---SPYVTKYYGSYL--K----------DTK--LWIIMEYLGGGSALDLLE---------PG----------------------------------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSE--------KKIHRDIKAANVLLS-E-----HGEVKLADFGVAGQL--------TDTQIKR--------------NT---FVGTPFWMAPEVIK------QSAYDSKADIWSLGITAIELAR-GE--------------PP---------------HSEL-----HPMKVLFLI----PKNNP---PTLEGNYS------------------------------KPLKE-FVEACLNKEPSFRPT-------AK-ELLKHKFI--------------
---F-TKLDRIGKGSFGEVYKGIDN----------------HTKEVVAIKII---DLE--EAEDEI---E-DIQ-Q-EITVLSQC--D---SPYITRYFGSYL--K----------STK--LWIIMEYLGGGSALDLLK---------PG----------------------------------------------------------------------------------------------------PLEETYIATILREILKGLDYLHSE--------RKIHRDIKAANVLLS-E-----QGDVKLADFGVAGQL--------TDTQIKR--------------NT---FVGTPFWMAPEVIK------QSAYDFKADIWSLGITAIELAK-GE--------------PP---------------NSDL-----HPMRVLFLI----PKNSP---PTLEGQHS------------------------------KPFKE-FVEACLNKDPRFRPT-------AK-ELLKHKFI--------------
----YELQEVIGSGATAVVQAALCK----------------PRQERVAIKRI---NLE--KCQTSM---D-E-LLK-EIQAMSQC--S---HPNVVTYYTSFV--V----------KDE--LWLVMKLLSGGSMLDIIKYIVNRGEHKNG----------------------------------------------------------------------------------------------------VLEEAIIATILKEVLEGLDYLHRN--------GQIHRDLKAGNILLG-E-----DGSVQIADFGVSAFLAT---GGDVTRNKVR--------------KT---FVGTPCWMAPEVME-----QVRGYDFKADMWSFGITAIELAT-GA--------------AP---------------YHKY-----PPMKVLMLT----LQNDP---PTLETGVEDKE--MMK-------------------KYGKSFRK-LLSLCLQKDPSKRPT-------AA-ELLKCKFF--------------
-TLE---DKELGSGNFGTVKKGYYQ--------------MKKVVKTVAVKIL---K-N--EAN-DPALKD-ELL-A-EANVMQQL--D---NPYIVRMIGICE-------------AES--WMLVMEMAELGPLNKYLQ---------QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEES--------NFVHRDLAARNVLLV-T-----QHYAKISDFGLSKAL----R---A--DENY-------------YKAQTHGKWPVKWYAPECIN------YYKFSSKSDVWSFGVLMWEAFSYGQ--------------KP---------------YRGM-----KGSEVTAML----EKGER---MGCPAGCP------------------------------REMYD-LMNLCWTYDVENRPG-------FA-AVE----LRL------------
----LTFMRELGSGLFGVVRLGKWR-----------------AQYKVAIKAI---R-E--GAM-CE---E-DFI-E-EAKVMMKL--T---HPKLVQLYGVCT--Q----------QKP--IYIVTEFMERGCLLNFLR---------QR--------------------------------------------------------------------------------------------------QGHFSRDVLLSMCQDVCEGMEYLERN--------SFIHRDLAARNCLVS-E-----AGVVKVSDFGMARYV--------L--DDQY--------------TSSSGAKFPVKWCPPEVFN------YSRFSSKSDVWSFGVLMWEVFTEGR--------------MP---------------FEKY-----TNYEVVTMV----TRGHR---LYQPKLAS------------------------------NYVYE-VMLRCWQEKPEGRPS-------FE-DLLRT--I--------------
--IV--LQESIGKGRFGEVWRGKWR----------------GEE--VAVKIF---SSR--EERSWF---R-EA----EIYQTVML--R---HENILGFIAADN--KDN------GTWTQ--LWLVSDYHEHGSLFDYLN---------RY----------------------------------------------------------------------------------------------------TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVK-K-----NGTCCIADLGLAVRHDS----ATDTIDIAP--------------NH---RVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIAR-RCSIGGI----HEDYQLP---------------YYDLVPSDPSVEEMRKVV----CEQKL---RPNIPNRWQSCEAL------------------------RVMAK-IMRECWYANGAARLT-------AL-RIKK----TL------------
-VCR---GELLGSGCFGVVHRGLWT-------------LPSGKSVPVAVKSLRVGP-E--GPM-GTE-LG-DFL-R-EVSVMMNL--E---HPHVLRLHGLVL-------------GQP--LQMVMELAPLGSLHARLT---------AP------------------------------------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGAR--------GLVHRDLATRNLLLA-S-----PRTIKVADFGLVRPL---GG---A--RGRY--------------VMGGPRPIPYAWCAPESLR------HGAFSSASDVWMFGVTLWEMFSGGE--------------EP---------------WAGV-----PPYLILQRL----EDRAR---LPRPPLCS------------------------------RALYS-LALRCWAPHPADRPS-------FS-HLE----GLL------------
---L-RLLEKLGDGSFGVVRRGEWD-------------APSGKTVSVAVKCL---K-PDVLSQ-PEA-MD-DFI-R-EVNAMHSL--D---HRNLIRLYGVVL-------------TPP--MKMVTELAPLGSLLDRLR---------KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK--------RFIHRDLAARNLLLA-T-----RDLVKIGDFGLMRAL---PQ---N--DDHY--------------VMQEHRKVPFAWCAPESLK------TRTFSHASDTWMFGVTLWEMFTYGQ--------------EP---------------WIGL-----NGSQILHKI---DKEGER---LPRPEDCP------------------------------QDIYN-VMVQCWAHKPEDRPT-------FV-ALRDF--L--------------
---L-AFIKEIGSGQFGVVHLGEWR-----------------SHIQVAIKAI---N-E--GSM-SE---E-DFI-E-EAKVMMKL--S---HSKLVQLYGVCI--Q----------RKP--LYIVTEFMENGCLLNYLR---------EN--------------------------------------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLERN--------GYIHRDLAARNCLVS-S-----TCIVKISDFGMTRYV--------L--DDEY--------------VSSFGAKFPIKWSPPEVFL------FNKYSSKSDVWSFGVLMWEVFTEGK--------------MP---------------FENK-----SNLQVVEAI----SEGFR---LYRPHLAP------------------------------MSIYE-VMYSCWHEKPEGRPT-------FA-ELLR---AV-------------
---L-KKIRDLGEGHFGKVSLYCYDP------------TNDGTGEMVAVKAL---K-A--DCG-PQH-RS-GWK-Q-EIDILRTL--Y---HEHIIKYKGCCEDQG----------EKS--LQLVMEYVPLGSLRDYLP---------RH----------------------------------------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHAQ--------HYIHRDLAARNVLLD-N-----DRLVKIGDFGLAKAV---PE---G--HEYY--------------RVREDGDSPVFWYAPECLK------EYKFYYASDVWSFGVTLYELLTHCD--------------SSQSPPTKF-LELIGIAQGQM-----TVLRLTELL----ERGER---LPRPDKCP------------------------------CEVYH-LMKNCWETEASFRPT-------FE-NLIP---IL-------------
---L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAIKTL---K-P--GTM-MP---E-AFL-Q-EAQIMKKL--R---HDKLVPLYAVVS-------------EEP--IYIVTEFMSKGSLLDFLK---------EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERM--------NYIHRDLRAANILVG-E-----NLVCKIADFGLARLI--------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILQTELVTKGR--------------VP---------------YPGM-----VNREVLEQV----ERGYR---MPCPQGCP------------------------------ESLHE-LMNLCWKKDPDERPT-------FE-YIQSFL----------------
LIAD----IELGCGNFGSVRQGVYR--------------MRKKQIDVAIKVL---K-Q--GTE-KAD-TE-EMM-R-EAQIMHQL--D---NPYIVRLIGVCQ-------------AEA--LMLVMEMAGGGPLHKFLV---------GK--------------------------------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEK--------NFVHRDLAARNVLLV-N-----RHYAKISDFGLSKAL---GA---D--DSYY--------------TARSAGKWPLKWYAPECIN------FRKFSSRSDVWSYGVTMWEALSYGQ--------------KP---------------YKKM-----KGPEVMAFI----EQGKR---MECPPECP------------------------------PELYA-LMSDCWIYKWEDRPD-------FL-TVEQR--M--------------
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