|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FGR 203
TK ABL1 261
TK ABL2 288
TKL ACVR1 208
TKL ACVR1B 207
Other AURKA 133
Other AURKB 77
TK BLK 241
TKL BMPR1A 234
TKL BMPR1B 204
TK BMX 422
TKL BRAF 456
TK BTK 402
TK CSF1R 582
TK CSK 195
TK DDR1 572
TK DDR2 563
TK EGFR 712
TK EPHA1 624
TK EPHA3 621
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB3 633
TK EPHB4 615
TK EPHB6 670
TK ERBB2 720
TK ERBB3 709
TK ERBB4 718
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FRK 234
TK FYN 271
TK HCK 241
TK INSR 1023
TK JAK2 849
TK JAK3 822
TK KDR 834
CAMK KIAA0999 66
TK KIT 589
TK LCK 245
TKL LIMK1 339
TKL LIMK2 331
TK LYN 247
STE MAP2K1 68
STE MAP2K5 166
TKL MAP3K7 36
STE MAP4K3 16
STE MAP4K4 25
CMGC MAPK14 24
STE MINK1 25
Other NEK2 8
TK PDGFRA 593
TK PDGFRB 600
TK PTK6 191
TK RET 724
TKL RIPK2 18
CAMK SIK1 27
CAMK SIK2 20
STE SLK 34
TK SRC 270
TK SRMS 230
STE STK10 36
Other STK36 4
TK SYK 371
TK TEC 370
TKL TGFBR1 205
STE TNIK 25
TK TNK2 150
TKL TNNI3K 463
TK TXK 271
TK TYK2 589
TK YES1 277
---ITLERRLGTGCFGDVWLGTWN-----------------GSTKVAV-KTLK-P--G-TM-SP---KAFL-E-EAQVMKLL--RHDKLVQLYAVVS---------EEPIYIVTEFMCHGSLLDFLK-----NP-------------------------------------------------------------------------------------------------EG-QDL---RLPQLVDMAAQVAEGMAYMER--M--------N---YIHRDLRAANILVGERL-ACKIADFGLARLI-----------------K--DDEY------------NPCQGSKFPIKWTAPEA--AL------FGR---FTIKSDVWSFGILLTELITKGR--------------IP---------------YPGM-----NKREVLEQV----EQ----GYH----MPCPPGCP-------------------------------------------ASLYE-AMEQTWRLDPEERPTFEYLQSFL-----
---ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAV-KTLK-E--D-TM-EV---EEFL-K-EAAVMKEI--KHPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR-----EC-------------------------------------------------------------------------------------------------NR-QEV---NAVVLLYMATQISSAMEYLEK--K--------N---FIHRDLAARNCLVGENH-LVKVADFGLSRLM-----------------T--GDTY------------TAHAGAKFPIKWTAPES--LA------YNK---FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYELL----EK----DYR----MERPEGCP-------------------------------------------EKVYE-LMRACWQWNPSDRPSFAEIHQA--F---
---ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAV-KTLK-E--D-TM-EV---EEFL-K-EAAVMKEI--KHPNLVQLLGVCT--L------EPPFYIVTEYMPYGNLLDYLR-----EC-------------------------------------------------------------------------------------------------NR-EEV---TAVVLLYMATQISSAMEYLEK--K--------N---FIHRDLAARNCLVGENH-VVKVADFGLSRLM-----------------T--GDTY------------TAHAGAKFPIKWTAPES--LA------YNT---FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYDLL----EK----GYR----MEQPEGCP-------------------------------------------PKVYE-LMRACWKWSPADRPSFAETHQA--F---
--I-TLLECVGKGRYGEVWRGSWQ----------------GEN--VAV-KIFSSR--D-EKSWF---RET----ELYNTVML--RHENILGFIASDM--TSR--HSSTQLWLITHYHEMGSLYDYLQ-----LT-----------------------------------------------------------------------------------------------------TL---DTVSCLRIVLSIASGLAHLHI--EIFGTQGKPA---IAHRDLKSKNILVKKNG-QCCIADLGLAVMHSQ-------------STNQLDVGN------------NP---RVGTKRYMAPEV--LDETIQVDCFD---SYKRVDIWAFGLVLWEVAR-RMVSNGI----VEDYKPP---------------FYDVVPNDPSFEDMRKVV----CV----DQQ----RPNIPNRWFSDPTL-------------------------------------TSLAK-LMKECWYQNPSARLTALRIKK----TL-
-IV--LQEIIGKGRFGEVWRGRWR----------------GGD--VAV-KIFSSR--E-ERSWF---REA----EIYQTVML--RHENILGFIAADN--KDN--GTWTQLWLVSDYHEHGSLFDYLN-----RY-----------------------------------------------------------------------------------------------------TV---TIEGMIKLALSAASGLAHLHM--EIVGTQGKPG---IAHRDLKSKNILVKKNG-MCAIADLGLAVRHDA-------------VTDTIDIAP------------NQ---RVGTKRYMAPEV--LDETINMKHFD---SFKCADIYALGLVYWEIAR-RCNSGGV----HEEYQLP---------------YYDLVPSDPSIEEMRKVV----CD----QKL----RPNIPNWWQSYEAL-------------------------------------RVMGK-MMRECWYANGAARLTALRIKK----TL-
---FEIGRPLGKGKFGNVYLAREK----------------QSKFILAL-KVLFKA--QLEKAGV---EHQLRR-EVEIQSHL--RHPNILRLYGYFH--D------ATRVYLILEYAPLGTVYRELQ----KLS-----------------------------------------------------------------------------------------------------KF---DEQRTATYITELANALSYCHS--K--------R---VIHRDIKPENLLLGSAG-ELKIADFGWSV-------------------HAPSSRR------------TT---LCGTLDYLPPEM--IE------GRM---HDEKVDLWSLGVLCYEFLV-GK--------------PP---------------FEAN--------TYQETY----KR----ISR----VEFTFPDFVT-----------------------------------------EGARD-LISRLLKHNPSQRPMLREVLEHPWI---
---FEIGRPLGKGKFGNVYLAREK----------------KSHFIVAL-KVLFKS--Q-IEKEG---VEHQLRREIEIQAHL--HHPNILRLYNYFY--D------RRRIYLILEYAPRGELYKELQ----KSC-----------------------------------------------------------------------------------------------------TF---DEQRTATIMEELADALMYCHG--K--------K---VIHRDIKPENLLLGLKG-ELKIADFGWSV-------------------HAPSLRR------------KT---MCGTLDYLPPEM--IE------GRM---HNEKVDLWCIGVLCYELLV-GN--------------PP---------------FESA--------SHNETY----RR----IVK----VDLKFPASVP-----------------------------------------MGAQD-LISKLLRHNPSERLPLAQVSAHPWV---
--L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAI-KTLK-E--G-TM-SP---EAFL-G-EANVMKAL--QHERLVRLYAVVT---------KEPIYIVTEYMARGCLLDFLK-----TD-------------------------------------------------------------------------------------------------EG-SRL---SLPRLIDMSAQIAEGMAYIER--M--------N---SIHRDLRAANILVSEAL-CCKIADFGLARII--------------------DSEY------------TAQEGAKFPIKWTAPEA--IH------FGV---FTIKADVWSFGVLLMEVVTYGR--------------VP---------------YPGM-----SNPEVIRNL----ER----GYR----MPRPDTCP-------------------------------------------PELYRGVIAECWRSRPEERPTFEFLQSV--L---
--I-QMVRQVGKGRYGEVWMGKWR----------------GEK--VAV-KVFFTT--E-EASWF---RET----EIYQTVLM--RHENILGFIAADI--KGT--GSWTQLYLITDYHENGSLYDFLK-----CA-----------------------------------------------------------------------------------------------------TL---DTRALLKLAYSAACGLCHLHT--EIYGTQGKPA---IAHRDLKSKNILIKKNG-SCCIADLGLAVKFNS-------------DTNEVDVPL------------NT---RVGTKRYMAPEV--LDESLNKNHFQ---PYIMADIYSFGLIIWEMAR-RCITGGI----VEEYQLP---------------YYNMVPSDPSYEDMREVV----CV----KRL----RPIVSNRWNSDECL-------------------------------------RAVLK-LMSECWAHNPASRLTALRIKK----TL-
--I-QMVKQIGKGRYGEVWMGKWR----------------GEK--VAV-KVFFTT--E-EASWF---RET----EIYQTVLM--RHENILGFIAADI--KGT--GSWTQLYLITDYHENGSLYDYLK-----ST-----------------------------------------------------------------------------------------------------TL---DAKSMLKLAYSSVSGLCHLHT--EIFSTQGKPA---IAHRDLKSKNILVKKNG-TCCIADLGLAVKFIS-------------DTNEVDIPP------------NT---RVGTKRYMPPEV--LDESLNRNHFQ---SYIMADMYSFGLILWEVAR-RCVSGGIVEEYQLPYHD-------------------LVPSDPSYEDMREIV----CI----KKL----RPSFPNRWSSDECL-------------------------------------RQMGK-LMTECWAHNPASRLTALRVKK----TL-
---ITLLKELGSGQFGVVQLGKWK-----------------GQYDVAV-KMIK-E--G-SM-SE---DEFF-Q-EAQTMMKL--SHPKLVKFYGVCS--K------EYPIYIVTEYISNGCLLNYLR-----SH--------------------------------------------------------------------------------------------------G-KGL---EPSQLLEMCYDVCEGMAFLES--H--------Q---FIHRDLAARNCLVDRDL-CVKVSDFGMTRYV-----------------L--DDQY------------VSSVGTKFPVKWSAPEV--FH------YFK---YSSKSDVWAFGILMWEVFSLGK--------------QP---------------YDLY-----DNSQVVLKV----SQ----GHR----LYRPHLAS-------------------------------------------DTIYQ-IMYSCWHELPEKRPTFQQLLSS--I---
---ITVGQRIGSGSFGTVYKGKWH-------------------GDVAV-KMLN-V-TA-PT-PQQ-LQAFK-N-EVGVLRKT--RHVNILLFMGYST---------KPQLAIVTQWCEGSSLYHHLH-----II--------------------------------------------------------------------------------------------------E-TKF---EMIKLIDIARQTAQGMDYLHA--K--------S---IIHRDLKSNNIFLHEDL-TVKIGDFGLATVK-------------S---R--WSGS------------HQFEQLSGSILWMAPEV--IR------MQDKNPYSFQSDVYAFGIVLYELMT-GQ--------------LP---------------YSNI-N---NRDQIIFMV----GR----GYLSPDLSKVRSNCP-------------------------------------------KAMKR-LMAECLKKKRDERPLFPQILA---SI--
---LTFLKELGTGQFGVVKYGKWR-----------------GQYDVAI-KMIK-E--G-SM-SE---DEFI-E-EAKVMMNL--SHEKLVQLYGVCT--K------QRPIFIITEYMANGCLLNYLR-----EM--------------------------------------------------------------------------------------------------R-HRF---QTQQLLEMCKDVCEAMEYLES--K--------Q---FLHRDLAARNCLVNDQG-VVKVSDFGLSRYV-----------------L--DDEY------------TSSVGSKFPVRWSPPEV--LM------YSK---FSSKSDIWAFGVLMWEIYSLGK--------------MP---------------YERF-----TNSETAEHI----AQ----GLR----LYRPHLAS-------------------------------------------EKVYT-IMYSCWHEKADERPTFKILLSN--I---
---LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAV-KMLK-S--T-AH-ADE-KEALM-S-ELKIMSHLG-QHENIVNLLGACT--H------GGPVLVITEYCCYGDLLNFLR-----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDG-RPL---ELRDLLHFSSQVAQGMAFLAS--K--------N---CIHRDVAARNVLLTNGH-VAKIGDFGLARDI-------------M---N--DSNY------------IVKGNARLPVKWMAPES--IF------DCV---YTVQSDVWSYGILLWEIFSLGL--------------NP---------------YPGI-L---VNSKFYKLV----KD----GYQ----MAQPAFAP-------------------------------------------KNIYS-IMQACWALEPTHRPTFQQICSFL-----
---LKLLQTIGKGEFGDVMLGDYR------------------GNKVAV-KCIK-N--D-AT-AQ----AFL-A-EASVMTQL--RHSNLVQLLGVIV-EE------KGGLYIVTEYMAKGSLVDYLR-----SR-------------------------------------------------------------------------------------------------GR-SVL---GGDCLLKFSLDVCEAMEYLEG--N--------N---FVHRDLAARNVLVSEDN-VAKVSDFGLTKEA-----------------------S------------STQDTGKLPVKWTAPEA--LR------EKK---FSTKSDVWSFGILLWEIYSFGR--------------VP---------------YPRI-----PLKDVVPRV----EK----GYK----MDAPDGCP-------------------------------------------PAVYE-VMKNCWHLDAAMRPSFLQLREQL-----
---LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAV-KILR-P--D-AT-KNA-RNDFL-K-EVKIMSRL--KDPNIIRLLGVCV--Q------DDPLCMITDYMENGDLNQFLS-----AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQG-PTI---SYPMLLHVAAQIASGMRYLAT--L--------N---FVHRDLATRNCLVGENF-TIKIADFGMSRNL-------------Y---A--GDYY------------RVQGRAVLPIRWMAWEC--IL------MGK---FTTASDVWAFGVTLWEVLMLCRA-------------QP---------------FGQL-----TDEQVIENAGEFFRD----QGRQ-VYLSRPPACP-------------------------------------------QGLYE-LMLRCWSRESEQRPPFSQLHRFL-----
---LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAV-KMLR-A--D-AN-KNA-RNDFL-K-EIKIMSRL--KDPNIIHLLAVCI--T------DDPLCMITEYMENGDLNQFLS-----RHEPPN-----------------------------------------------------------------------------------------SSSSDV-RTV---SYTNLKFMATQIASGMKYLSS--L--------N---FVHRDLATRNCLVGKNY-TIKIADFGMSRNL-------------Y---S--GDYY------------RIQGRAVLPIRWMSWES--IL------LGK---FTTASDVWAFGVTLWETFTFCQE-------------QP---------------YSQL-----SDEQVIENT----GEFFRDQGRQ-TYLPQPAICP-------------------------------------------DSVYK-LMLSCWRRDTKNRPSFQEIHL---LL--
--F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKIPVAI-KELR-E--A-TS-PKA-NKEIL-D-EAYVMASV--DNPHVCRLLGICL---------TSTVQLITQLMPFGCLLDYVR-----EH--------------------------------------------------------------------------------------------------K-DNI---GSQYLLNWCVQIAKGMNYLED--R--------R---LVHRDLAARNVLVKTPQ-HVKITDFGLAKLL-------------G---A--EEKE------------YHAEGGKVPIKWMALES--IL------HRI---YTHQSDVWSYGVTVWELMTFGS--------------KP---------------YDGI-----PASEISSIL----EK----GER----LPQPPICT-------------------------------------------IDVYM-IMVKCWMIDADSRPKFRELI----IEF-
-LM--VDTVIGEGEFGEVYRGTLR-------------LPSQDCKTVAI-KTLK-D--T-SP-GGQ-WWNFL-R-EATIMGQF--SHPHILHLEGVVT--K------RKPIMIITEFMENGALDAFLR-----ER--------------------------------------------------------------------------------------------------E-DQL---VPGQLVAMLQGIASGMNYLSN--H--------N---YVHRDLAARNILVNQNL-CCKVSDFGLTRLL-------------D---D--FDGT------------YETQGGKIPIRWTAPEA--IA------HRI---FTTASDVWSFGIVMWEVLSFGD--------------KP---------------YGEM-----SNQEVMKSI----ED----GYR----LPPPVDCP-------------------------------------------APLYE-LMKNCWAYDRARRPHFQKLQAHL-----
--I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEISVAI-KTLK-V--G-YT-EKQ-RRDFL-G-EASIMGQF--DHPNIIRLEGVVT--K------SKPVMIVTEYMENGSLDSFLR-----KH--------------------------------------------------------------------------------------------------D-AQF---TVIQLVGMLRGIASGMKYLSD--M--------G---YVHRDLAARNILINSNL-VCKVSDFGLSRVL-------------E---D--DPEA-----------AYTTRGGKIPIRWTSPEA--IA------YRK---FTSASDVWSYGIVLWEVMSYGE--------------RP---------------YWEM-----SNQDVIKAV----DE----GYR----LPPPMDCP-------------------------------------------AALYQ-LMLDCWQKDRNNRPKFEQIVSIL-----
---IHIEKIIGSGDSGEVCYGRLR-------------VPGQRDVPVAI-KALK-A--G-YT-ERQ-RRDFL-S-EASIMGQF--DHPNIIRLEGVVT--R------GRLAMIVTEYMENGSLDTFLR-----TH--------------------------------------------------------------------------------------------------D-GQF---TIMQLVGMLRGVGAGMRYLSD--L--------G---YVHRDLAARNVLVDSNL-VCKVSDFGLSRVL-------------E---D--DPDA-----------AYTTTGGKIPIRWTAPEA--IA------FRT---FSSASDVWSFGVVMWEVLAYGE--------------RP---------------YWNM-----TNRDVISSV----EE----GYR----LPAPMGCP-------------------------------------------HALHQ-LMLDCWHKDRAQRPRFSQIVSVL-----
--V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREIYVAI-KTLK-A--G-YS-EKQ-RRDFL-S-EASIMGQF--DHPNIIRLEGVVT--K------SRPVMIITEFMENGALDSFLR-----QN--------------------------------------------------------------------------------------------------D-GQF---TVIQLVGMLRGIAAGMKYLAE--M--------N---YVHRDLAARNILVNSNL-VCKVSDFGLSRYLQ----------DDT---S--DPTY------------TSSLGGKIPVRWTAPEA--IA------YRK---FTSASDVWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDVINAI----EQ----DYR----LPPPMDCP-------------------------------------------AALHQ-LMLDCWQKDRNSRPRFAEIVNTL-----
--V-KIEQVIGAGEFGEVCSGHLK-------------LPGKREIFVAI-KTLK-S--G-YT-EKQ-RRDFL-S-EASIMGQF--DHPNVIHLEGVVT--K------STPVMIITEFMENGSLDSFLR-----QN--------------------------------------------------------------------------------------------------D-GQF---TVIQLVGMLRGIAAGMKYLAD--M--------N---YVHRDLAARNILVNSNL-VCKVSDFGLSRFLE----------DDT---S--DPTY------------TSALGGKIPIRWTAPEA--IQ------YRK---FTSASDVWSYGIVMWEVMSYGE--------------RP---------------YWDM-----TNQDVINAI----EQ----DYR----LPPPMDCP-------------------------------------------SALHQ-LMLDCWQKDRNHRPKFGQIVNTL-----
--V-KIEEVIGAGEFGEVCRGRLK-------------QPGRREVFVAI-KTLK-V--G-YT-ERQ-RRDFL-S-EASIMGQF--DHPNIIRLEGVVT--K------SRPVMILTEFMENCALDSFLR-----LN--------------------------------------------------------------------------------------------------D-GQF---TVIQLVGMLRGIAAGMKYLSE--M--------N---YVHRDLAARNILVNSNL-VCKVSDFGLSRFLE----------DDP---S--DPTY------------TSSLGGKIPIRWTAPEA--IA------YRK---FTSASDVWSYGIVMWEVMSYGE--------------RP---------------YWDM-----SNQDVINAV----EQ----DYR----LPPPMDCP-------------------------------------------TALHQ-LMLDCWVRDRNLRPKFSQIVNTL-----
--V-KIEEVIGAGEFGEVCRGRLK-------------APGKKESCVAI-KTLK-G--G-YT-ERQ-RREFL-S-EASIMGQF--EHPNIIRLEGVVT--N------SMPVMILTEFMENGALDSFLR-----LN--------------------------------------------------------------------------------------------------D-GQF---TVIQLVGMLRGIASGMRYLAE--M--------S---YVHRDLAARNILVNSNL-VCKVSDFGLSRFLE----------ENS---S--DPTY------------TSSLGGKIPIRWTAPEA--IA------FRK---FTSASDAWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDVINAI----EQ----DYR----LPPPPDCP-------------------------------------------TSLHQ-LMLDCWQKDRNARPRFPQVVSAL-----
---IKIEEVIGTGSFGEVRQGRLQ-------------PRGRREQTVAI-QALW-A--G-GA-ESL-QMTFL-G-RAAVLGQF--QHPNILRLEGVVT--K------SRPLMVLTEFMELGPLDSFLR-----QR--------------------------------------------------------------------------------------------------E-GQF---SSLQLVAMQRGVAAAMQYLSS--F--------A---FVHRSLSAHSVLVNSHL-VCKVARLGHSPQG-----------------------------------------PSCLLRWAAPEV--IA------HGK---HTTSSDVWSFGILMWEVMSYGE--------------RP---------------YWDM-----SEQEVLNAI----EQ----EFR----LPPPPGCP-------------------------------------------PGLHL-LMLDTWQKDRARRPHFDQLVA---AF--
--L-RKVKVLGSGAFGTVYKGIWIP------------DGENVKIPVAI-KVLR-E--N-TS-PKA-NKEIL-D-EAYVMAGV--GSPYVSRLLGICL---------TSTVQLVTQLMPYGCLLDHVR-----EN--------------------------------------------------------------------------------------------------R-GRL---GSQDLLNWCMQIAKGMSYLED--V--------R---LVHRDLAARNVLVKSPN-HVKITDFGLARLL-------------D---I--DETE------------YHADGGKVPIKWMALES--IL------RRR---FTHQSDVWSYGVTVWELMTFGA--------------KP---------------YDGI-----PAREIPDLL----EK----GER----LPQPPICT-------------------------------------------IDVYM-IMVKCWMIDSECRPRFRELVSE--F---
--L-RKLKVLGSGVFGTVHKGVWIP------------EGESIKIPVCI-KVIE-D--K-SG-RQS-FQAVT-D-HMLAIGSL--DHAHIVRLLGLCP---------GSSLQLVTQYLPLGSLLDHVR-----QH--------------------------------------------------------------------------------------------------R-GAL---GPQLLLNWGVQIAKGMYYLEE--H--------G---MVHRNLAARNVLLKSPS-QVQVADFGVADLL-------------P---P--DDKQ------------LLYSEAKTPIKWMALES--IH------FGK---YTHQSDVWSYGVTVWELMTFGA--------------EP---------------YAGL-----RLAEVPDLL----EK----GER----LAQPQICT-------------------------------------------IDVYM-VMVKCWMIDENIRPTFKELANE--F---
--L-KRVKVLGSGAFGTVYKGIWVP------------EGETVKIPVAI-KILN-E--T-TG-PKA-NVEFM-D-EALIMASM--DHPHLVRLLGVCL---------SPTIQLVTQLMPHGCLLEYVH-----EH--------------------------------------------------------------------------------------------------K-DNI---GSQLLLNWCVQIAKGMMYLEE--R--------R---LVHRDLAARNVLVKSPN-HVKITDFGLARLL-------------E---G--DEKE------------YNADGGKMPIKWMALEC--IH------YRK---FTHQSDVWSYGVTIWELMTFGG--------------KP---------------YDGI-----PTREIPDLL----EK----GER----LPQPPICT-------------------------------------------IDVYM-VMVKCWMIDADSRPKFKELAAE--F---
--L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAV-KMLK-S--D-AT-EKD-LSDLI-S-EMEMMKMIG-KHKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLQ-----ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPE-EQL---SSKDLVSCAYQVARGMEYLAS--K--------K---CIHRDLAARNVLVTEDN-VMKIADFGLARDI-------------H---H--IDYY------------KKTTNGRLPVKWMAPEA--LF------DRI---YTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGV-----PVEELFKLL----KE----GHR----MDKPSNCT-------------------------------------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL-----
---LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAV-KMLK-D--D-AT-EKD-LSDLV-S-EMEMMKMIG-KHKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLR-----ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPE-EQM---TFKDLVSCTYQLARGMEYLAS--Q--------K---CIHRDLAARNVLVTENN-VMKIADFGLARDI-------------N---N--IDYY------------KKTTNGRLPVKWMAPEA--LF------DRV---YTHQSDVWSFGVLMWEIFTLGG--------------SP---------------YPGI-----PVEELFKLL----KE----GHR----MDKPANCT-------------------------------------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL-----
---LTLGKPLGEGCFGQVVMAEAIGI---------DKDRAAKPVTVAV-KMLK-D--D-AT-DKD-LSDLV-S-EMEMMKMIG-KHKNIINLLGACT--Q------GGPLYVLVEYAAKGNLREFLR-----ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPE-EQL---TFKDLVSCAYQVARGMEYLAS--Q--------K---CIHRDLAARNVLVTEDN-VMKIADFGLARDV-------------H---N--LDYY------------KKTTNGRLPVKWMAPEA--LF------DRV---YTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGI-----PVEELFKLL----KE----GHR----MDKPANCT-------------------------------------------HDLYM-IMRECWHAAPSQRPTFKQLVEDL-----
---IQLLKRLGSGQFGEVWEGLWN-----------------NTTPVAV-KTLK-P--G-SM-DP---NDFL-R-EAQIMKNL--RHPKLIQLYAVCT--L------EDPIYIITELMRHGSLQEYLQ-----ND-------------------------------------------------------------------------------------------------TG-SKI---HLTQQVDMAAQVASGMAYLES--R--------N---YIHRDLAARNVLVGEHN-IYKVADFGLARVFK-----------VD---N--EDIY------------ESRHEIKLPVKWTAPEA--IR------SNK---FSIKSDVWSFGILLYEIITYGK--------------MP---------------YSGM-----TGAQVIQML----AQ----NYR----LPQPSNCP-------------------------------------------QQFYN-IMLECWNAEPKERPTFETLRWK--L---
---LQLIKRLGNGQFGEVWMGTWN-----------------GNTKVAI-KTLK-P--G-TM-SP---ESFL-E-EAQIMKKL--KHDKLVQLYAVVS---------EEPIYIVTEYMNKGSLLDFLK-----DG-------------------------------------------------------------------------------------------------EG-RAL---KLPNLVDMAAQVAAGMAYIER--M--------N---YIHRDLRSANILVGNGL-ICKIADFGLARLI-----------------E--DNEY------------TARQGAKFPIKWTAPEA--AL------YGR---FTIKSDVWSFGILLTELVTKGR--------------VP---------------YPGM-----NNREVLEQV----ER----GYR----MPCPQDCP-------------------------------------------ISLHE-LMIHCWKKDPEERPTFEYLQSFL-----
---LKLEKKLGAGQFGEVWMATYN-----------------KHTKVAV-KTMK-P--G-SM-SV---EAFL-A-EANVMKTL--QHDKLVKLHAVVT---------KEPIYIITEFMAKGSLLDFLK-----SD-------------------------------------------------------------------------------------------------EG-SKQ---PLPKLIDFSAQIAEGMAFIEQ--R--------N---YIHRDLRAANILVSASL-VCKIADFGLARVI-----------------E--DNEY------------TAREGAKFPIKWTAPEA--IN------FGS---FTIKSDVWSFGILLMEIVTYGR--------------IP---------------YPGM-----SNPEVIRAL----ER----GYR----MPRPENCP-------------------------------------------EELYN-IMMRCWKNRPEERPTFEYIQSV--L---
---ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAV-KTVN-E--S-AS-LRE-RIEFL-N-EASVMKGF--TCHHVVRLLGVVS--K------GQPTLVVMELMAHGDLKSYLR-----SLRPEA-----------------------------------------------------------------------------------------ENNPGR-PPP---TLQEMIQMAAEIADGMAYLNA--K--------K---FVHRDLAARNCMVAHDF-TVKIGDFGMTRDI-------------Y---E--TDYY------------RKGGKGLLPVRWMAPES--LK------DGV---FTTSSDMWSFGVVLWEITSLAE--------------QP---------------YQGL-----SNEQVLKFV----MD----GGY----LDQPDNCP-------------------------------------------ERVTD-LMRMCWQFNPKMRPTFLEIVNLL-----
---LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAV-KKLQ-H--S-TE--EH-LRDFE-R-EIEILKSL--QHDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ-----KH--------------------------------------------------------------------------------------------------K-ERI---DHIKLLQYTSQICKGMEYLGT--K--------R---YIHRDLATRNILVENEN-RVKIGDFGLTKVL------------PQ---D--KEYY------------KVKEPGESPIFWYAPES--LT------ESK---FSVASDVWSFGVVLYELFTYIE--------------KSKSPPAEFMRMIGNDKQGQM-----IVFHLIELL----KN----NGR----LPRPDGCP-------------------------------------------DEIYM-IMTECWNNNVNQRPSFRDLA----LRV-
--L-KYISQLGKGNFGSVELCRYDP------------LGDNTGALVAV-KQLQ-H--S-GP-DQ--QRDFQ-R-EIQILKAL--HSDFIVKYRGVSYGPG------RQSLRLVMEYLPSGCLRDFLQ-----RH--------------------------------------------------------------------------------------------------R-ARL---DASRLLLYSSQICKGMEYLGS--R--------R---CVHRDLAARNILVESEA-HVKIADFGLAKLL------------PL---D--KDYY------------VVREPGQSPIFWYAPES--LS------DNI---FSRQSDVWSFGVVLYELFTYCD--------------KSCSPSAE--FLRMMGCERDV-P---ALCRLLELL----EE----GQR----LPAPPACP-------------------------------------------AEVHE-LMKLCWAPSPQDRPSFSALGP---QL--
---LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAV-KMLK-E--G-AT-HSE-HRALM-S-ELKILIHIG-HHLNVVNLLGACT-KP------GGPLMVIVEFCKFGNLSTYLR-----SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYK-DFL---TLEHLICYSFQVAKGMEFLAS--R--------K---CIHRDLAARNILLSEKN-VVKICDFGLARDI-------------Y---K--DPDY------------VRKGDARLPLKWMAPET--IF------DRV---YTIQSDVWSFGVLLWEIFSLGA--------------SP---------------YPGV-K---IDEEFCRRL----KE----GTR----MRAPDYTT-------------------------------------------PEMYQ-TMLDCWHGEPSQRPTFSELVEHL-----
---YEIDRTIGKGNFAVVKRATHL----------------VTKAKVAI-KIIDKT--Q-LDEEN---LKKIFR-EVQIMKML--CHPHIIRLYQVME--T------ERMIYLVTEYASGGEIFDHLV----AHG-----------------------------------------------------------------------------------------------------RM---AEKEARRKFKQIVTAVYFCHC--R--------N---IVHRDLKAENLLLDANL-NIKIADFGFSNL------------------FTPGQLL------------KT---WCGSPPYAAPEL--FE-----GKEY---DGPKVDIWSLGVVLYVLVC-GA--------------LP---------------FDGS--------TLQNLR----AR----VLS----GKFRIPFFMS-----------------------------------------TECEH-LIRHMLVLDPNKRLSMEQICKHKWM---
---LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAV-KMLK-P--S-AH-LTE-REALM-S-ELKVLSYLG-NHMNIVNLLGACT--I------GGPTLVITEYCCYGDLLNFLR-----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDE-LAL---DLEDLLSFSYQVAKGMAFLAS--K--------N---CIHRDLAARNILLTHGR-ITKICDFGLARDI-------------K---N--DSNY------------VVKGNARLPVKWMAPES--IF------NCV---YTFESDVWSYGIFLWELFSLGS--------------SP---------------YPGM-P---VDSKFYKMI----KE----GFR----MLSPEHAP-------------------------------------------AEMYD-IMKTCWDADPLKRPTFKQIVQL--I---
---LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAV-KSLK-Q--G-SM-SP---DAFL-A-EANLMKQL--QHQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK-----TP-------------------------------------------------------------------------------------------------SG-IKL---TINKLLDMAAQIAEGMAFIEE--R--------N---YIHRDLRAANILVSDTL-SCKIADFGLARLI-----------------E--DNEY------------TAREGAKFPIKWTAPEA--IN------YGT---FTIKSDVWSFGILLTEIVTHGR--------------IP---------------YPGM-----TNPEVIQNL----ER----GYR----MVRPDNCP-------------------------------------------EELYQ-LMRLCWKERPEDRPTFDYLRSV--L---
-LI--HGEVLGKGCFGQAIKVTHR----------------ETGEVMVM-KELI----R-FD-EET-QRTFL-K-EVKVMRCL--EHPNVLKFIGVLY--K------DKRLNFITEYIKGGTLRGIIK-----SM--------------------------------------------------------------------------------------------------D-SQY---PWSQRVSFAKDIASGMAYLHS--M--------N---IIHRDLNSHNCLVRENK-NVVVADFGLARLM-------------V---D--EKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEM--IN------GRS---YDEKVDVFSFGIVLCEIIGRVN--------------AD---------------PDYL-P---RTMDFGLNV----RG----FLD----RYCPPNCP-------------------------------------------PSFFP-ITVRCCDLDPEKRPSFVKLEH---WL--
-LI--HGEVLGKGFFGQAIKVTHK-----------------ATGKVMVMKEL--I--R-CD-EET-QKTFL-T-EVKVMRSL--DHPNVLKFIGVLY--K------DKKLNLLTEYIEGGTLKDFLR-----SM----------------------------------------------------------------------------------------------------DPF---PWQQKVRFAKGIASGMAYLHS--M--------C---IIHRDLNSHNCLIKLDK-TVVVADFGLSRLIVEERKRAPMEKATT---------KKRTL---RKNDRKKRYTVVGNPYWMAPEM--LN------GKS---YDETVDIFSFGIVLCEIIGQVY--------------AD---------------PDCL-P---RTLDFGLNV----KL----FWE----KFVPTDCP-------------------------------------------PAFFP-LAAICCRLEPESRPAFSKLED---SF--
---IKLVKRLGAGQFGEVWMGYYN-----------------NSTKVAV-KTLK-P--G-TM-SV---QAFL-E-EANLMKTL--QHDKLVRLYAVVT--R------EEPIYIITEYMAKGSLLDFLK-----SD-------------------------------------------------------------------------------------------------EG-GKV---LLPKLIDFSAQIAEGMAYIER--K--------N---YIHRDLRAANVLVSESL-MCKIADFGLARVI-----------------E--DNEY------------TAREGAKFPIKWTAPEA--IN------FGC---FTIKSDVWSFGILLYEIVTYGK--------------IP---------------YPGR-----TNADVMTAL----SQ----GYR----MPRVENCP-------------------------------------------DELYD-IMKMCWKEKAEERPTFDYLQSV--L---
---FEKISELGAGNGGVVFKVSHK----------------PSGL-VMA-RKLIHL--E-IKPAI---RNQIIR-ELQVLHEC--NSPYIVGFYGAFY--S------DGEISICMEHMDGGSLDQVLK----KAG-----------------------------------------------------------------------------------------------------RI---PEQILGKVSIAVIKGLTYLRE-KH--------K---IMHRDVKPSNILVNSRG-EIKLCDFGVSG-------------------QLIDSMA------------NS---FVGTRSYMSPER--LQ------GTH---YSVQSDIWSMGLSLVEMAV-GR--------------YP---------------IPPP-----DAKELELMF----GC----QVE----GDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQD-FVNKCLIKNPAERADLKQLMVHAFI---
IRY---RDTLGHGNGGTVYKAYHV----------------PSGKILAV-KVILLD--I-TLELQ---KQI-MS-ELEILYKC--DSSYIIGFYGAFF--V------ENRISICTEFMDGGSLD--------VYR-----------------------------------------------------------------------------------------------------KM---PEHVLGRIAVAVVKGLTYLWS--L--------K---ILHRDVKPSNMLVNTRG-QVKLCDFGVST-------------------QLVNSIA------------KT---YVGTNAYMAPER--IS------GEQ---YGIHSDVWSLGISFMELAL-GR--------------FP---------------YPQI-----QKNQGSLMP----LQ----LLQ----CIVDEDSPVLPVGEF-----------------------------------SEPFVH-FITQCMRKQPKERPAPEELMGHPFI---
---IEVEEVVGRGAFGVVCKAKWR------------------AKDVAI-KQIE-------S-ESE-RKAFI-V-ELRQLSRV--NHPNIVKLYGACL----------NPVCLVMEYAEGGSLYNVLH-----GA-------------------------------------------------------------------------------------------------EPLPYY---TAAHAMSWCLQCSQGVAYLHS--M--------QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDI-----------------------Q------------THMTNNKGSAAWMAPEV--FE------GSN---YSEKCDVFSWGIILWEVITR-R--------------KP---------------FDEIGG---PAFRIMWAV----HN----GTR----PPLIKNLP-------------------------------------------KPIES-LMTRCWSKDPSQRPSMEEIVKI--M---
---FELIQRIGSGTYGDVYKARNV----------------NTGELAAI-KVIKLE--P-GEDFA---VVQ--Q-EIIMMKDC--KHPNIVAYFGSYL--R------RDKLWICMEFCGGGSLQDIYH----VTG-----------------------------------------------------------------------------------------------------PL---SELQIAYVSRETLQGLYYLHS--K--------G---KMHRDIKGANILLTDNG-HVKLADFGVSAQI-----------------TATIAKR------------KS---FIGTPYWMAPEVAAVE-----RKGG---YNQLCDLWAVGITAIELAE-LQ--------------PP---------------MFDL-----HPMRALFLM----TK----SNF----QPP--KLKDKMKWS-------------------------------------NSFHH-FVKMALTKNPKKRPTAEKLLQHPFV---
---FELVEVVGNGTYGQVYKGRHV----------------KTGQLAAI-KVMDVT--E-DEEEE---IKL----EINMLKKY-SHHRNIATYYGAFI--KKSPPGHDDQLWLVMEFCGAGSITDLVKN--TKGN-----------------------------------------------------------------------------------------------------TL---KEDWIAYISREILRGLAHLHI--H--------H---VIHRDIKGQNVLLTENA-EVKLVDFGVSAQL-----------------DRTVGRR------------NT---FIGTPYWMAPEV--IACD-ENPDAT---YDYRSDLWSCGITAIEMAE-GA--------------PP---------------LCDM-----HPMRALFLI----PR----NPP----PRLKSKKWS------------------------------------------KKFFS-FIEGCLVKNYMQRPSTEQLLKHPFI---
---YQNLSPVGSGAYGSVCAAFDT----------------KTGLRVAV-KKLSRP--F-QSIIH---AKRTYR-ELRLLKHM--KHENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK-----CQ-----------------------------------------------------------------------------------------------------KL---TDDHVQFLIYQILRGLKYIHS--A--------D---IIHRDLKPSNLAVNEDC-ELKILDFGLAR--------------------HTDDEM------------TG---YVATRWYRAPEI--ML-----NWMH---YNQTVDIWSVGCIMAELLT-GR--------------TL---------------FPGT-----DHIDQLKLI----LR----LVG----TPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVD-LLEKMLVLDSDKRITAAQALAHAYF---
---FELVEVVGNGTYGQVYKGRHV----------------KTGQLAAI-KVMDVT--E-DEEEE---IKQ----EINMLKKY-SHHRNIATYYGAFI--KKSPPGNDDQLWLVMEFCGAGSVTDLVKN--TKGN-----------------------------------------------------------------------------------------------------AL---KEDCIAYICREILRGLAHLHA--H--------K---VIHRDIKGQNVLLTENA-EVKLVDFGVSAQL-----------------DRTVGRR------------NT---FIGTPYWMAPEV--IACD-ENPDAT---YDYRSDIWSLGITAIEMAE-GA--------------PP---------------LCDM-----HPMRALFLI----PR----NPP----PRLKSKKWS------------------------------------------KKFID-FIDTCLIKTYLSRPPTEQLLKFPFI---
---YEVLYTIGTGSYGRCQKIRRK----------------SDGKILVW-KELDYG--S-MTEAE---KQMLVS-EVNLLREL--KHPNIVRYYDRII--DR----TNTTLYIVMEYCEGGDLASVITKGTKERQ-----------------------------------------------------------------------------------------------------YL---DEEFVLRVMTQLTLALKECHR--RSD---GGHT---VLHRDLKPANVFLDGKQ-NVKLGDFGLARIL-----------------NHDTSFA------------KT---FVGTPYYMSPEQ--MN------RMS---YNEKSDIWSLGCLLYELCA-LM--------------PP---------------FTAF--------SQKELA----GK----IRE----GKFRRIPYRY---S-------------------------------------DELNE-IITRMLNLKDYHRPSVEEILENPL-I--
--L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAV-KMLK-P--T-AR-SSE-KQALM-S-ELKIMTHLG-PHLNIVNLLGACT--K------SGPIYIITEYCFYGDLVNYLH-----KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNS-EGL---TLLDLLSFTYQVARGMEFLAS--K--------N---CVHRDLAARNVLLAQGK-IVKICDFGLARDI-------------M---H--DSNY------------VSKGSTFLPVKWMAPES--IF------DNL---YTTLSDVWSYGILLWEIFSLGG--------------TP---------------YPGM-M---VDSTFYNKI----KS----GYR----MAKPDHAT-------------------------------------------SEVYE-IMVKCWNSEPEKRPSFYHLSE---IV--
--L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAV-KMLK-S--T-AR-SSE-KQALM-S-ELKIMSHLG-PHLNVVNLLGACT--K------GGPIYIITEYCRYGDLVDYLH-----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINES-PVL---SYMDLVGFSYQVANGMEFLAS--K--------N---CVHRDLAARNVLICEGK-LVKICDFGLARDI-------------M---R--DSNY------------ISKGSTFLPLKWMAPES--IF------NSL---YTTLSDVWSFGILLWEIFTLGG--------------TP---------------YPEL-P---MNEQFYNAI----KR----GYR----MAQPAHAS-------------------------------------------DEIYE-IMQKCWEEKFEIRPPFSQLVL---LL--
--F-TLCRKLGSGYFGEVFEGLWK-----------------DRVQVAI-KVIS-R--D-NL-LH--QQMLQ-S-EIQAMKKL--RHKHILALYAVVS--V------GDPVYIITELMAKGSLLELLR-----DS-------------------------------------------------------------------------------------------------DE-KVL---PVSELLDIAWQVAEGMCYLES--Q--------N---YIHRDLAARNILVGENT-LCKVGDFGLARLI--------------------KEDV------------YLSHDHNIPYKWTAPEA--LS------RGH---YSTKSDVWSFGILLHEMFSRGQ--------------VP---------------YPGM-----SNHEAFLRV----DA----GYR----MPCPLECP-------------------------------------------PSVHK-LMLTCWCRDPEQRPCFKALRERL-----
--L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYTTVAV-KMLK-E--N-AS-PSE-LRDLL-S-EFNVLKQV--NHPHVIKLYGACS--Q------DGPLLLIVEYAKYGSLRGFLR-----ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDE-RAL---TMGDLISFAWQISQGMQYLAE--M--------K---LVHRDLAARNILVAEGR-KMKISDFGLSRDV-------------Y---E--EDSY------------VKRSQGRIPVKWMAIES--LF------DHI---YTTQSDVWSFGVLLWEIVTLGG--------------NP---------------YPGI-----PPERLFNLL----KT----GHR----MERPDNCS-------------------------------------------EEMYR-LMLQCWKQEPDKRPVFADISKDL-----
LAD---LRYLSRGASGTVSSARHA----------------DWRVQVAV-KHLHIH--T-PLLDS---ERKDVLREAEILHKA--RFSYILPILGICN--E------PEFLGIVTEYMPNGSLNELLH----RKT-----------------------------------------------------------------------------------------------------EYPDVAWPLRFRILHEIALGVNYLHN--MT------PP---LLHHDLKTQNILLDNEF-HVKIADFGLSKWRMM------------SLSQSRSSKS------------AP---EGGTIIYMPPEN--YEP---GQKSR---ASIKHDIYSYAVITWEVLS-RK--------------QP---------------FEDVT---NPLQIMYSVS----QG----HRP----VINEESLPYDIPHR-------------------------------------ARMIS-LIESGWAQNPDERPSFLKCL-----IEL
---YDIERTLGKGNFAVVKLARHR----------------VTKTQVAI-KIIDKT--R-LDSSN---LEKIYR-EVQLMKLL--NHPHIIKLYQVME--T------KDMLYIVTEFAKNGEMFDYLT----SNG-----------------------------------------------------------------------------------------------------HL---SENEARKKFWQILSAVEYCHD--H--------H---IVHRDLKTENLLLDGNM-DIKLADFGFGNF------------------YKSGEPL------------ST---WCGSPPYAAPEV--FE-----GKEY---EGPQLDIWSLGVVLYVLVC-GS--------------LP---------------FDGP--------NLPTLR----QR----VLE----GRFRIPFFMS-----------------------------------------QDCES-LIRRMLVVDPARRITIAQIRQHRWM---
---YDIEGTLGKGNFAVVKLGRHR----------------ITKTEVAI-KIIDKS--Q-LDAVN---LEKIYR-EVQIMKML--DHPHIIKLYQVME--T------KSMLYLVTEYAKNGEIFDYLA----NHG-----------------------------------------------------------------------------------------------------RL---NESEARRKFWQILSAVDYCHG--R--------K---IVHRDLKAENLLLDNNM-NIKIADFGFGNF------------------FKSGELL------------AT---WCGSPPYAAPEV--FE-----GQQY---EGPQLDIWSMGVVLYVLVC-GA--------------LP---------------FDGP--------TLPILR----QR----VLE----GRFRIPYFMS-----------------------------------------EDCEH-LIRRMLVLDPSKRLTIAQIKEHKWM---
---WEIIGELGDGAFGKVYKAQNK----------------ETSVLAAA-KVIDTK--S-EEELE---DYM--V-EIDILASC--DHPNIVKLLDAFY--Y------ENNLWILIEFCAGGAVDAVML---ELER-----------------------------------------------------------------------------------------------------PL---TESQIQVVCKQTLDALNYLHD--N--------K---IIHRDLKAGNILFTLDG-DIKLADFGVSAKN-----------------TRTIQRR------------DS---FIGTPYWMAPEV--VMCE-TSKDRP---YDYKADVWSLGITLIEMAE-IE--------------PP---------------HHEL-----NPMRVLLKI----AK----SEP----PTLAQPSRWS-----------------------------------------SNFKD-FLKKCLEKNVDARWTTSQLLQHPFV---
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAI-KTLK-P--G-TM-SP---EAFL-Q-EAQVMKKL--RHEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK-----GE-------------------------------------------------------------------------------------------------TG-KYL---RLPQLVDMAAQIASGMAYVER--M--------N---YVHRDLRAANILVGENL-VCKVADFGLARLI-----------------E--DNEY------------TARQGAKFPIKWTAPEA--AL------YGR---FTIKSDVWSFGILLTELTTKGR--------------VP---------------YPGM-----VNREVLDQV----ER----GYR----MPCPPECP-------------------------------------------ESLHD-LMCQCWRKEPEERPTFEYLQAF--L---
-FA--LGRKLGEGYFGEVWEGLWL-----------------GSLPVAI-KVIK-S--A-NM-K---LTDLA-K-EIQTLKGL--RHERLIRLHAVCS--G------GEPVYIVTELMRKGNLQAFLG-----TP-------------------------------------------------------------------------------------------------EG-RAL---RLPPLLGFACQVAEGMSYLEE--Q--------R---VVHRDLAARNVLVDDGL-ACKVADFGLARLL-----------------K--DDIY------------SPSSSSKIPVKWTAPEA--AN------YRV---FSQKSDVWSFGVLLHEVFTYGQ--------------CP---------------YEGM-----TNHETLQQI----MR----GYR----LPRPAACP-------------------------------------------AEVYV-LMLECWRSSPEERPSFATLREKL-----
---WEIVGELGDGAFGKVYKAKNK----------------ETGALAAA-KVIETK--S-EEELE---DYI--V-EIEILATC--DHPYIVKLLGAYY--H------DGKLWIMIEFCPGGAVDAIML---ELDR-----------------------------------------------------------------------------------------------------GL---TEPQIQVVCRQMLEALNFLHS--K--------R---IIHRDLKAGNVLMTLEG-DIRLADFGVSAKN-----------------LKTLQKR------------DS---FIGTPYWMAPEV--VMCE-TMKDTP---YDYKADIWSLGITLIEMAQ-IE--------------PP---------------HHEL-----NPMRVLLKI----AK----SDP----PTLLTPSKWS-----------------------------------------VEFRD-FLKIALDKNPETRPSAAQLLEHPFV---
---YHVLEMIGEGSFGRVYKGRRK----------------YSAQVVAL-KFIPKL--G-RSEKE---LRNLQR-EIEIMRGL--RHPNIVHMLDSFE--T------DKEVVVVTDYAEG-ELFQILE----DDG-----------------------------------------------------------------------------------------------------KL---PEDQVQAIAAQLVSALYYLHS--H--------R---ILHRDMKPQNILLAKGG-GIKLCDFGFARAM-----------------STNTMVL------------TS---IKGTPLYMSPEL--VE------ERP---YDHTADLWSVGCILYELAV-GT--------------PP---------------FYAT--------SIFQLV----SL----ILK----DPVRWPSTIS-----------------------------------------PCFKN-FLQGLLTKDPRQRLSWPDLLYHPFI---
TLE---DKELGSGNFGTVKKGYYQ--------------MKKVVKTVAV-KILK-N--E-AN-DPALKDELL-A-EANVMQQL--DNPYIVRMIGICE---------AESWMLVMEMAELGPLNKYLQ-----QN----------------------------------------------------------------------------------------------------RHV---KDKNIIELVHQVSMGMKYLEE--S--------N---FVHRDLAARNVLLVTQH-YAKISDFGLSKAL-------------R---A--DENY-----------YKAQTHGKWPVKWYAPEC--IN------YYK---FSSKSDVWSFGVLMWEAFSYGQ--------------KP---------------YRGM-----KGSEVTAML----EK----GER----MGCPAGCP-------------------------------------------REMYD-LMNLCWTYDVENRPGFAAVE----LRL-
---LTFMRELGSGLFGVVRLGKWR-----------------AQYKVAI-KAIR-E--G-AM-CE---EDFI-E-EAKVMMKL--THPKLVQLYGVCT--Q------QKPIYIVTEFMERGCLLNFLR-----QR--------------------------------------------------------------------------------------------------Q-GHF---SRDVLLSMCQDVCEGMEYLER--N--------S---FIHRDLAARNCLVSEAG-VVKVSDFGMARYV-----------------L--DDQY------------TSSSGAKFPVKWCPPEV--FN------YSR---FSSKSDVWSFGVLMWEVFTEGR--------------MP---------------FEKY-----TNYEVVTMV----TR----GHR----LYQPKLAS-------------------------------------------NYVYE-VMLRCWQEKPEGRPSFEDLLRT--I---
-IV--LQESIGKGRFGEVWRGKWR----------------GEE--VAV-KIFSSR--E-ERSWF---REA----EIYQTVML--RHENILGFIAADN--KDN--GTWTQLWLVSDYHEHGSLFDYLN-----RY-----------------------------------------------------------------------------------------------------TV---TVEGMIKLALSTASGLAHLHM--EIVGTQGKPA---IAHRDLKSKNILVKKNG-TCCIADLGLAVRHDS-------------ATDTIDIAP------------NH---RVGTKRYMAPEV--LDDSINMKHFE---SFKRADIYAMGLVFWEIAR-RCSIGGI----HEDYQLP---------------YYDLVPSDPSVEEMRKVV----CE----QKL----RPNIPNRWQSCEAL-------------------------------------RVMAK-IMRECWYANGAARLTALRIKK----TL-
---FELVELVGNGTYGQVYKGRHV----------------KTGQLAAI-KVMDVT--G-DEEEE---IKQ----EINMLKKY-SHHRNIATYYGAFI--KKNPPGMDDQLWLVMEFCGAGSVTDLIKN--TKGN-----------------------------------------------------------------------------------------------------TL---KEEWIAYICREILRGLSHLHQ--H--------K---VIHRDIKGQNVLLTENA-EVKLVDFGVSAQL-----------------DRTVGRR------------NT---FIGTPYWMAPEV--IACD-ENPDAT---YDFKSDLWSLGITAIEMAE-GA--------------PP---------------LCDM-----HPMRALFLI----PR----NPA----PRLKSKKWS------------------------------------------KKFQS-FIESCLVKNHSQRPATEQLMKHPFI---
--L-RLLEKLGDGSFGVVRRGEWD-------------APSGKTVSVAV-KCLK-PDVL-SQ-PEA-MDDFI-R-EVNAMHSL--DHRNLIRLYGVVL---------TPPMKMVTELAPLGSLLDRLR-----KH--------------------------------------------------------------------------------------------------Q-GHF---LLGTLSRYAVQVAEGMGYLES--K--------R---FIHRDLAARNLLLATRD-LVKIGDFGLMRAL------------PQ---N--DDHY------------VMQEHRKVPFAWCAPES--LK------TRT---FSHASDTWMFGVTLWEMFTYGQ--------------EP---------------WIGL-----NGSQILHKI---DKE----GER----LPRPEDCP-------------------------------------------QDIYN-VMVQCWAHKPEDRPTFVALRDF--L---
---IEFHEIIGSGSFGKVYKGRCR------------------NKIVAI-KRYR-ANTY-CS-KSD-VDMFC-R-EVSILCQL--NHPCVIQFVGACL-ND------PSQFAIVTQYISGGSLFSLLH-----EQ--------------------------------------------------------------------------------------------------K-RIL---DLQSKLIIAVDVAKGMEYLHNLTQ--------P---IIHRDLNSHNILLYEDG-HAVVADFGESRFL-------------Q---S--LD-E------------DNMTKQPGNLRWMAPEV--FT------QCT--RYTIKADVFSYALCLWEILT-GE--------------IP---------------FAHL-----KPAAAAADM---AYH----HIR----PPIGYSIP-------------------------------------------KPISS-LLIRGWNACPEGRPEFSEVVMKL-----
--L-AFIKEIGSGQFGVVHLGEWR-----------------SHIQVAI-KAIN-E--G-SM-SE---EDFI-E-EAKVMMKL--SHSKLVQLYGVCI--Q------RKPLYIVTEFMENGCLLNYLR-----EN--------------------------------------------------------------------------------------------------K-GKL---RKEMLLSVCQDICEGMEYLER--N--------G---YIHRDLAARNCLVSSTC-IVKISDFGMTRYV-----------------L--DDEY------------VSSFGAKFPIKWSPPEV--FL------FNK---YSSKSDVWSFGVLMWEVFTEGK--------------MP---------------FENK-----SNLQVVEAI----SE----GFR----LYRPHLAP-------------------------------------------MSIYE-VMYSCWHEKPEGRPTFAELLR---AV--
--L-KKIRDLGEGHFGKVSLYCYDP------------TNDGTGEMVAV-KALK-A--D-CG-PQH-RSGWK-Q-EIDILRTL--YHEHIIKYKGCCEDQG------EKSLQLVMEYVPLGSLRDYLP-----RH-----------------------------------------------------------------------------------------------------SI---GLAQLLLFAQQICEGMAYLHA--Q--------H---YIHRDLAARNVLLDNDR-LVKIGDFGLAKAV------------PE---G--HEYY------------RVREDGDSPVFWYAPEC--LK------EYK---FYYASDVWSFGVTLYELLTHCD--------------SSQSPPTKF-LELIGIAQGQM-----TVLRLTELL----ER----GER----LPRPDKCP-------------------------------------------CEVYH-LMKNCWETEASFRPTFENLIP---IL--
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAI-KTLK-P--G-TM-MP---EAFL-Q-EAQIMKKL--RHDKLVPLYAVVS---------EEPIYIVTEFMSKGSLLDFLK-----EG-------------------------------------------------------------------------------------------------DG-KYL---KLPQLVDMAAQIADGMAYIER--M--------N---YIHRDLRAANILVGENL-VCKIADFGLARLI-----------------E--DNEY------------TARQGAKFPIKWTAPEA--AL------YGR---FTIKSDVWSFGILQTELVTKGR--------------VP---------------YPGM-----VNREVLEQV----ER----GYR----MPCPQGCP-------------------------------------------ESLHE-LMNLCWKKDPDERPTFEYIQSFL-----
|