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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FGR 203
TK ABL1 261
TK ABL2 288
TKL ACVR1 208
TKL ACVR1B 207
TK ALK 1116
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK BLK 241
TKL BMPR1A 234
TKL BMPR1B 204
TK BMX 422
CAMK BRSK1 50
CAMK BRSK2 19
TK BTK 402
CMGC CDC2 4
CMGC CDC2L5 705
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDK6 13
CMGC CDKL1 5
CMGC CDKL2 4
CMGC CDKL3 4
CMGC CDKL5 13
TK CSF1R 582
TK CSK 195
CAMK DAPK1 13
CAMK DAPK3 13
TK DDR1 572
TK DDR2 563
TK EGFR 712
TK EPHA1 624
TK EPHA3 621
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB4 615
TK EPHB6 670
TK ERBB2 720
TK ERBB4 718
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FLT4 845
TK FRK 234
TK FYN 271
TK HCK 241
CAMK HUNK 61
CMGC ICK 4
TK IGF1R 999
TK INSR 1023
TK INSRR 979
TKL IRAK4 186
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK KDR 834
CAMK KIAA0999 66
TK KIT 589
TK LCK 245
TKL LIMK1 339
TKL LIMK2 331
TK LTK 510
TK LYN 247
CMGC MAK 4
STE MAP2K1 68
STE MAP2K5 166
TKL MAP3K7 36
STE MAP4K3 16
STE MAP4K4 25
CMGC MAPK14 24
CAMK MARK2 53
CAMK MARK4 59
TK MATK 235
CAMK MELK 11
TK MET 1078
CAMK MGC42105 74
STE MINK1 25
TK MUSK 575
STE MYO3A 21
Other NEK1 4
Other NEK2 8
Other NEK4 6
Other NEK5 4
Other NEK8 4
Other NEK9 52
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
CAMK NUAK2 97
STE OXSR1 17
TK PDGFRA 593
TK PDGFRB 600
AGC PDPK1 82
AGC PKN1 615
AGC PKN2 657
Other PLK2 82
Other PLK3 62
Other PLK4 12
CAMK PRKAA1 18
CAMK PRKAA2 16
AGC PRKACA 44
AGC PRKACB 44
AGC PRKACG 44
AGC PRKCA 339
AGC PRKCB 342
AGC PRKCD 349
AGC PRKCE 408
AGC PRKCH 355
AGC PRKCQ 380
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
AGC PRKG1 375
AGC PRKG2 453
AGC PRKX 49
TK PTK2B 425
TK PTK6 191
TK RET 724
TKL RIPK2 18
TKL RIPK4 22
TK ROS1 1945
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA6 73
AGC RPS6KB1 91
CAMK SIK1 27
CAMK SIK2 20
STE SLK 34
CAMK SNRK 16
TK SRC 270
TK SRMS 230
STE STK10 36
STE STK24 24
Other STK36 4
STE STK39 63
TK SYK 371
TK TEC 370
TK TEK 824
TKL TGFBR1 205
TK TIE1 839
STE TNIK 25
TK TNK1 116
TK TNK2 150
TKL TNNI3K 463
CAMK TSSK2 12
TK TXK 271
TK TYK2 589
Other ULK1 16
Other ULK2 9
TK YES1 277
TK ZAP70 338
-----ITLERRLGTGCFGDV---WLGTW---N-----------------GST---KVAV-KTL---K-P--G-TM-SP---K-A-FL-E----EAQVMKLL--R---HDKLVQLYAVVS-------------EEP--IYIVTEFMCHGSLLDFLK---------NP-------------------------------------------------------------------------------------------------EG-QDL---RLPQLVDMAAQVAEGMAYMER--M--------N---YIHRDLRAANILVG-E-----RL-AC---------KIADFGLARLI-----------------K--DDEY--------------NPCQGSKFPIKWTAPEA--AL------FGR-FTIKSDVWSFGILLTELITKGR--------------IP---------------YPGM-----NKREVLEQV----EQ----GYH---MPCPPGCP-------------------------------------------ASLYE-AMEQTWRLDPEERPT-------FE-YLQSFL----------------
-----ITMKHKLGGGQYGEV---YEGVW---K----------------KYSL---TVAV-KTL---K-E--D-TM-EV---E-E-FL-K----EAAVMKEI--K---HPNLVQLLGVCT--R----------EPP--FYIITEFMTYGNLLDYLR---------EC-------------------------------------------------------------------------------------------------NR-QEV---NAVVLLYMATQISSAMEYLEK--K--------N---FIHRDLAARNCLVG-E-----NH-LV---------KVADFGLSRLM-----------------T--GDTY--------------TAHAGAKFPIKWTAPES--LA------YNK-FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYELL----EK----DYR---MERPEGCP-------------------------------------------EKVYE-LMRACWQWNPSDRPS-------FA-EIHQA--F--------------
-----ITMKHKLGGGQYGEV---YVGVW---K----------------KYSL---TVAV-KTL---K-E--D-TM-EV---E-E-FL-K----EAAVMKEI--K---HPNLVQLLGVCT--L----------EPP--FYIVTEYMPYGNLLDYLR---------EC-------------------------------------------------------------------------------------------------NR-EEV---TAVVLLYMATQISSAMEYLEK--K--------N---FIHRDLAARNCLVG-E-----NH-VV---------KVADFGLSRLM-----------------T--GDTY--------------TAHAGAKFPIKWTAPES--LA------YNT-FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYDLL----EK----GYR---MEQPEGCP-------------------------------------------PKVYE-LMRACWKWSPADRPS-------FA-ETHQA--F--------------
----I-TLLECVGKGRYGEV---WRGSW---Q----------------GEN-----VAV-KIF---SSR--D-EKSWF---R-E-T-------ELYNTVML--R---HENILGFIASDM--TSR------HSSTQ--LWLITHYHEMGSLYDYLQ---------LT-----------------------------------------------------------------------------------------------------TL---DTVSCLRIVLSIASGLAHLHI--EIFGTQGKPA---IAHRDLKSKNILVK-K-----NG-QC---------CIADLGLAVMHSQ-------------STNQLDVGN--------------NP---RVGTKRYMAPEV--LDETIQVDCFD-SYKRVDIWAFGLVLWEVAR-RMVSNGI----VEDYKPP---------------FYDVVPNDPSFEDMRKVV----CV----DQQ---RPNIPNRWFSDPTL-------------------------------------TSLAK-LMKECWYQNPSARLT-------AL-RIKK----TL------------
---IV--LQEIIGKGRFGEV---WRGRW---R----------------GGD-----VAV-KIF---SSR--E-ERSWF---R-E-A-------EIYQTVML--R---HENILGFIAADN--KDN------GTWTQ--LWLVSDYHEHGSLFDYLN---------RY-----------------------------------------------------------------------------------------------------TV---TIEGMIKLALSAASGLAHLHM--EIVGTQGKPG---IAHRDLKSKNILVK-K-----NG-MC---------AIADLGLAVRHDA-------------VTDTIDIAP--------------NQ---RVGTKRYMAPEV--LDETINMKHFD-SFKCADIYALGLVYWEIAR-RCNSGGV----HEEYQLP---------------YYDLVPSDPSIEEMRKVV----CD----QKL---RPNIPNWWQSYEAL-------------------------------------RVMGK-MMRECWYANGAARLT-------AL-RIKK----TL------------
----I-TLIRGLGHGAFGEV---YEGQV---SG-----------MPNDPSPL---QVAV-KTL---P-E--V-CS-EQD-EL-D-FL-M----EALIISKF--N---HQNIVRCIGVSL--Q----------SLP--RFILLELMAGGDLKSFLR---------ETRP--------------------------------------------------------------------------------------------RPSQP-SSL---AMLDLLHVARDIACGCQYLEE--N--------H---FIHRDIAARNCLLT-CP--GPGR-VA---------KIGDFGMARDI-------------Y---R--ASYY--------------RKGGCAMLPVKWMPPEA--FM------EGI-FTSKTDTWSFGVLLWEIFSLGY--------------MP---------------YPSK-----SNQEVLEFV----TS----GGR---MDPPKNCP-------------------------------------------GPVYR-IMTQCWQHQPEDRPN-------FA-IILER--I--------------
-----FEIGRPLGKGKFGNV---YLARE---K----------------QSKF---ILAL-KVL---FKA--QLEKAGV---E-H-QLRR----EVEIQSHL--R---HPNILRLYGYFH--D----------ATR--VYLILEYAPLGTVYRELQ--------KLS-----------------------------------------------------------------------------------------------------KF---DEQRTATYITELANALSYCHS--K--------R---VIHRDIKPENLLLG-S-----AG-EL---------KIADFGWSV-------------------HAPSSRR--------------TT---LCGTLDYLPPEM--IE------GRM-HDEKVDLWSLGVLCYEFLV-GK--------------PP---------------FEAN--------TYQETY----KR----ISR---VEFTFPDFVT-----------------------------------------EGARD-LISRLLKHNPSQRPM-------LR-EVLEHPWI--------------
-----FEIGRPLGKGKFGNV---YLARE---K----------------KSHF---IVAL-KVL---FKS--Q-IEKEG---V-E-HQLR---REIEIQAHL--H---HPNILRLYNYFY--D----------RRR--IYLILEYAPRGELYKELQ--------KSC-----------------------------------------------------------------------------------------------------TF---DEQRTATIMEELADALMYCHG--K--------K---VIHRDIKPENLLLG-L-----KG-EL---------KIADFGWSV-------------------HAPSLRR--------------KT---MCGTLDYLPPEM--IE------GRM-HNEKVDLWCIGVLCYELLV-GN--------------PP---------------FESA--------SHNETY----RR----IVK---VDLKFPASVP-----------------------------------------MGAQD-LISKLLRHNPSERLP-------LA-QVSAHPWV--------------
-----FEIGRPLGKGKFGNV---YLARL---K----------------ESHF---IVAL-KVL---FKS--Q-IEKEG---L-E-HQLR---REIEIQAHL--Q---HPNILRLYNYFH--D----------ARR--VYLILEYAPRGELYKELQ--------KSE-----------------------------------------------------------------------------------------------------KL---DEQRTATIIEELADALTYCHD--K--------K---VIHRDIKPENLLLG-F-----RG-EV---------KIADFGWSV-------------------HTPSLRR--------------KT---MCGTLDYLPPEM--IE------GRT-YDEKVDLWCIGVLCYELLV-GY--------------PP---------------FESA--------SHSETY----RR----ILK---VDVRFPLSMP-----------------------------------------LGARD-LISRLLRYQPLERLP-------LA-QILKHPWV--------------
----L-RLVRKLGSGQFGEV---WMGYY---K-----------------NNM---KVAI-KTL---K-E--G-TM-SP---E-A-FL-G----EANVMKAL--Q---HERLVRLYAVVT-------------KEP--IYIVTEYMARGCLLDFLK---------TD-------------------------------------------------------------------------------------------------EG-SRL---SLPRLIDMSAQIAEGMAYIER--M--------N---SIHRDLRAANILVS-E-----AL-CC---------KIADFGLARII--------------------DSEY--------------TAQEGAKFPIKWTAPEA--IH------FGV-FTIKADVWSFGVLLMEVVTYGR--------------VP---------------YPGM-----SNPEVIRNL----ER----GYR---MPRPDTCP-------------------------------------------PELYRGVIAECWRSRPEERPT-------FE-FLQSV--L--------------
----I-QMVRQVGKGRYGEV---WMGKW---R----------------GEK-----VAV-KVF---FTT--E-EASWF---R-E-T-------EIYQTVLM--R---HENILGFIAADI--KGT------GSWTQ--LYLITDYHENGSLYDFLK---------CA-----------------------------------------------------------------------------------------------------TL---DTRALLKLAYSAACGLCHLHT--EIYGTQGKPA---IAHRDLKSKNILIK-K-----NG-SC---------CIADLGLAVKFNS-------------DTNEVDVPL--------------NT---RVGTKRYMAPEV--LDESLNKNHFQ-PYIMADIYSFGLIIWEMAR-RCITGGI----VEEYQLP---------------YYNMVPSDPSYEDMREVV----CV----KRL---RPIVSNRWNSDECL-------------------------------------RAVLK-LMSECWAHNPASRLT-------AL-RIKK----TL------------
----I-QMVKQIGKGRYGEV---WMGKW---R----------------GEK-----VAV-KVF---FTT--E-EASWF---R-E-T-------EIYQTVLM--R---HENILGFIAADI--KGT------GSWTQ--LYLITDYHENGSLYDYLK---------ST-----------------------------------------------------------------------------------------------------TL---DAKSMLKLAYSSVSGLCHLHT--EIFSTQGKPA---IAHRDLKSKNILVK-K-----NG-TC---------CIADLGLAVKFIS-------------DTNEVDIPP--------------NT---RVGTKRYMPPEV--LDESLNRNHFQ-SYIMADMYSFGLILWEVAR-RCVSGGIVEEYQLPYHD-------------------LVPSDPSYEDMREIV----CI----KKL---RPSFPNRWSSDECL-------------------------------------RQMGK-LMTECWAHNPASRLT-------AL-RVKK----TL------------
-----ITLLKELGSGQFGVV---QLGKW---K-----------------GQY---DVAV-KMI---K-E--G-SM-SE---D-E-FF-Q----EAQTMMKL--S---HPKLVKFYGVCS--K----------EYP--IYIVTEYISNGCLLNYLR---------SH--------------------------------------------------------------------------------------------------G-KGL---EPSQLLEMCYDVCEGMAFLES--H--------Q---FIHRDLAARNCLVD-R-----DL-CV---------KVSDFGMTRYV-----------------L--DDQY--------------VSSVGTKFPVKWSAPEV--FH------YFK-YSSKSDVWAFGILMWEVFSLGK--------------QP---------------YDLY-----DNSQVVLKV----SQ----GHR---LYRPHLAS-------------------------------------------DTIYQ-IMYSCWHELPEKRPT-------FQ-QLLSS--I--------------
-----YRLEKTLGKGQTGLV---KLGVH---C----------------ITGQ---KVAI-KIV---NRE--K-LSESV---L-M-KVER----EIAILKLI--E---HPHVLKLHDVYE--N----------KKY--LYLVLEHVSGGELFDYLV--------KKG-----------------------------------------------------------------------------------------------------RL---TPKEARKFFRQIVSALDFCHS--Y--------S---ICHRDLKPENLLLD-E-----KN-NI---------RIADFGMASL------------------QVGDSLL--------------ET---SCGSPHYACPEV--IK-----GEKY-DGRRADMWSCGVILFALLV-GA--------------LP---------------FDDD--------NLRQLL----EK----VKR---GVFHMPHFIP-----------------------------------------PDCQS-LLRGMIEVEPEKRLS-------LE-QIQKHPW-Y-------------
-----YRLEKTLGKGQTGLV---KLGVH---C----------------VTCQ---KVAI-KIV---NRE--K-LSESV---L-M-KVER----EIAILKLI--E---HPHVLKLHDVYE--N----------KKY--LYLVLEHVSGGELFDYLV--------KKG-----------------------------------------------------------------------------------------------------RL---TPKEARKFFRQIISALDFCHS--H--------S---ICHRDLKPENLLLD-E-----KN-NI---------RIADFGMASL------------------QVGDSLL--------------ET---SCGSPHYACPEV--IR-----GEKY-DGRKADVWSCGVILFALLV-GA--------------LP---------------FDDD--------NLRQLL----EK----VKR---GVFHMPHFIP-----------------------------------------PDCQS-LLRGMIEVDAARRLT-------LE-HIQKHIW-Y-------------
-----LTFLKELGTGQFGVV---KYGKW---R-----------------GQY---DVAI-KMI---K-E--G-SM-SE---D-E-FI-E----EAKVMMNL--S---HEKLVQLYGVCT--K----------QRP--IFIITEYMANGCLLNYLR---------EM--------------------------------------------------------------------------------------------------R-HRF---QTQQLLEMCKDVCEAMEYLES--K--------Q---FLHRDLAARNCLVN-D-----QG-VV---------KVSDFGLSRYV-----------------L--DDEY--------------TSSVGSKFPVRWSPPEV--LM------YSK-FSSKSDIWAFGVLMWEIYSLGK--------------MP---------------YERF-----TNSETAEHI----AQ----GLR---LYRPHLAS-------------------------------------------EKVYT-IMYSCWHEKADERPT-------FK-ILLSN--I--------------
-----YTKIEKIGEGTYGVV---YKGRH---K----------------TTGQ---VVAM-KKI---RLE--S-EEEGV---P-S-TAIR----EISLLKEL--R---HPNIVSLQDVLM--Q----------DSR--LYLIFEFLSM-DLKKYLDS-----IPPGQ-----------------------------------------------------------------------------------------------------YM---DSSLVKSYLYQILQGIVFCHS--R--------R---VLHRDLKPQNLLID-D-----KG-TI---------KLADFGLARAF-----------------GIPIRVY--------------TH---EVVTLWYRSPEV--LL-----GSAR-YSTPVDIWSIGTIFAELAT-KK--------------PL---------------FHGD-----SEIDQLFRI----FR----ALG---TPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-------GK-MALNHPYF--------------
----F-DIIGIIGEGTYGQV---YKARD---K----------------DTGE---MVAL-KKV---RLD--N-EKEGF---P-I-TAIR----EIKILRQL--T---HQSIINMKEIVT--DKEDALDFKKDKGA--FYLVFEYMDH-DLMGLLE-------SGLV-----------------------------------------------------------------------------------------------------HF---NENHIKSFMRQLMEGLDYCHK--K--------N---FLHRDIKCSNILLN-N-----RG-QI---------KLADFGLARLY----------------SSEESRPY--------------TN---KVITLWYRPPEL--LL-----GEER-YTPAIDVWSCGCILGELFT-KK--------------PI---------------FQAN-----QELAQLELI----SR----ICG---SPCPAVWPDVIKLPYFNTMKPKKQY--------------RRKLREEFVFIPAAALD-LFDYMLALDPSKRCT-------AE-QALQCEF-L-------------
-----FQKVEKIGEGTYGVV---YKARN---K----------------LTGE---VVAL-KKI---RLD--T-ETEGV---P-S-TAIR----EISLLKEL--N---HPNIVKLLDVIH--T----------ENK--LYLVFEFLHQ-DLKKFMDA------SALT-----------------------------------------------------------------------------------------------------GI---PLPLIKSYLFQLLQGLAFCHS--H--------R---VLHRDLKPQNLLIN-T-----EG-AI---------KLADFGLARAF-----------------GVPVRTY--------------TH---EVVTLWYRAPEI--LL-----GCKY-YSTAVDIWSLGCIFAEMVT-RR--------------AL---------------FPGD-----SEIDQLFRI----FR----TLG---TPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-------AK-AALAHPFF--------------
-----FQKVEKIGEGTYGVV---YKAKN---R----------------ETGQ---LVAL-KKI---RLD--L-EMEGV---P-S-TAIR----EISLLKEL--K---HPNIVRLLDVVH--N----------ERK--LYLVFEFLSQ-DLKKYMDS------TPGS-----------------------------------------------------------------------------------------------------EL---PLHLIKSYLFQLLQGVSFCHS--H--------R---VIHRDLKPQNLLIN-E-----LG-AI---------KLADFGLARAF-----------------GVPLRTY--------------TH---EVVTLWYRAPEI--LL-----GSKF-YTTAVDIWSIGCIFAEMVT-RK--------------AL---------------FPGD-----SEIDQLFRI----FR----MLG---TPSEDTWPGVTQLPDYKGSFPKWTR---------------KGLEEIVPNLEPEGRD-LLMQLLQYDPSQRIT-------AK-TALAHPYF--------------
-----YEKLEKIGEGTYGTV---FKAKN---R----------------ETHE---IVAL-KRV---RLD--D-DDEGV---P-S-SALR----EICLLKEL--K---HKNIVRLHDVLH--S----------DKK--LTLVFEFCDQ-DLKKYFD-------SCNG-----------------------------------------------------------------------------------------------------DL---DPEIVKSFLFQLLKGLGFCHS--R--------N---VLHRDLKPQNLLIN-R-----NG-EL---------KLADFGLARAF-----------------GIPVRCY--------------SA---EVVTLWYRPPDV--LF-----GAKL-YSTSIDMWSAGCIFAELANAGR--------------PL---------------FPGN-----DVDDQLKRI----FR----LLG---TPTEEQWPSMTKLPDYKPYPMYPAT---------------TSLVNVVPKLNATGRD-LLQNLLKCNPVQRIS-------AE-EALQHPYF--------------
-----YECVAEIGEGAYGKV---FKARD---L----------------KNGG--RFVAL-KRV---RVQ--T-GEEGM---P-L-STIR----EVAVLRHL--ETFEHPNVVRLFDVCT--VSR-----TDRETK--LTLVFEHVDQ-DLTTYLDK------VPEP-----------------------------------------------------------------------------------------------------GV---PTETIKDMMFQLLRGLDFLHS--H--------R---VVHRDLKPQNILVT-S-----SG-QI---------KLADFGLARI------------------YSFQMAL--------------TS---VVVTLWYRAPEV--LL------QSS-YATPVDLWSVGCIFAEMFR-RK--------------PL---------------FRGS-----SDVDQLGKI----LD----VIG---LPGEEDWPRDVALPRQAFHSKSAQ-----------------PIEKFVTDIDELGKD-LLLKCLTFNPAKRIS-------AY-SALSHPYF--------------
-----YEKIGKIGEGSYGVV---FKCRN---R----------------DTGQ---IVAI-KKF---LES--E-DDPVI---K-K-IALR----EIRMLKQL--K---HPNLVNLLEVFR--R----------KRR--LHLVFEYCDHTVLHELDR--------YQR-----------------------------------------------------------------------------------------------------GV---PEHLVKSITWQTLQAVNFCHK--H--------N---CIHRDVKPENILIT-K-----HS-VI---------KLCDFGFARLL-----------------AGPSDYY--------------TD---YVATRWYRSPEL--LV-----GDTQ-YGPPVDVWAIGCVFAELLS-GV--------------PL---------------WPGK-----SDVDQLYLI----RK----TLG---DLIPRHQQVFSTNQYFSGVKIPDPED-------------MEPLELKFPNISYPALG-LLKGCLHMDPTQRLT-------CE-QLLHHPYF--------------
-----YENLGLVGEGSYGMV---MKCRN---K----------------DTGR---IVAI-KKF---LES--D-DDKMV---K-K-IAMR----EIKLLKQL--R---HENLVNLLEVCK--K----------KKR--WYLVFEFVDHTILDDLEL--------FPN-----------------------------------------------------------------------------------------------------GL---DYQVVQKYLFQIINGIGFCHS--H--------N---IIHRDIKPENILVS-Q-----SG-VV---------KLCDFGFARTL-----------------AAPGEVY--------------TD---YVATRWYRAPEL--LV-----GDVK-YGKAVDVWAIGCLVTEMFM-GE--------------PL---------------FPGD-----SDIDQLYHI----MM----CLG---NLIPRHQELFNKNPVFAGVRLPEIKE-------------REPLERRYPKLSEVVID-LAKKCLHIDPDKRPF-------CA-ELLHHDFF--------------
-----YETLGKVGEGSYGTV---MKCKH---K----------------NTGQ---IVAI-KIF---YER--P-EQSVN---K---IAMR----EIKFLKQF--H---HENLVNLIEVFR--Q----------KKK--IHLVFEFIDHTVLDELQH--------YCH-----------------------------------------------------------------------------------------------------GL---ESKRLRKYLFQILRAIDYLHS--N--------N---IIHRDIKPENILVS-Q-----SG-IT---------KLCDFGFARTL-----------------AAPGDIY--------------TD---YVATRWYRAPEL--VL-----KDTS-YGKPVDIWALGCMIIEMAT-GN--------------PY---------------LPSS-----SDLDLLHKI----VL----KVG---N-LSPHLQNIFSKSPIFAGVVLPQVQ------------HPKNARKKYPKLNGLLAD-IVHACLQIDPADRIS-------SS-DLLHHEYF--------------
-----FEILGVVGEGAYGVV---LKCRH---K----------------ETHE---IVAI-KKF---KDS--E-ENEEV---K-E-TTLR----ELKMLRTL--K---QENIVELKEAFR--R----------RGK--LYLVFEYVEK-NMLELLE-------EMPN-----------------------------------------------------------------------------------------------------GV---PPEKVKSYIYQLIKAIHWCHK--N--------D---IVHRDIKPENLLIS-H-----ND-VL---------KLCDFGFARNL----------------SEGNNANY--------------TE---YVATRWYRSPEL--LL------GAP-YGKSVDMWSVGCILGELSD-GQ--------------PL---------------FPGE-----SEIDQLFTI----QK----VLG---PLPSEQMKLFYSNPRFHGLRFPAVNH------------PQSLERRYLGILNSVLLD-LMKNLLKLDPADRYL-------TE-QCLNHPTF--------------
-----LQFGKTLGAGAFGKV---VEATA---FG-----------LGKEDAVL---KVAV-KML---K-S--T-AH-ADE-KE-A-LM-S----ELKIMSHLG-Q---HENIVNLLGACT--H----------GGP--VLVITEYCCYGDLLNFLR---------RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDG-RPL---ELRDLLHFSSQVAQGMAFLAS--K--------N---CIHRDVAARNVLLT-N-----GH-VA---------KIGDFGLARDI-------------M---N--DSNY--------------IVKGNARLPVKWMAPES--IF------DCV-YTVQSDVWSYGILLWEIFSLGL--------------NP---------------YPGI-L---VNSKFYKLV----KD----GYQ---MAQPAFAP-------------------------------------------KNIYS-IMQACWALEPTHRPT-------FQ-QICSFL----------------
-----LKLLQTIGKGEFGDV---MLGDY---R------------------GN---KVAV-KCI---K-N--D-AT-AQ-----A-FL-A----EASVMTQL--R---HSNLVQLLGVIV-EE----------KGG--LYIVTEYMAKGSLVDYLR---------SR-------------------------------------------------------------------------------------------------GR-SVL---GGDCLLKFSLDVCEAMEYLEG--N--------N---FVHRDLAARNVLVS-E-----DN-VA---------KVSDFGLTKEA-----------------------S--------------STQDTGKLPVKWTAPEA--LR------EKK-FSTKSDVWSFGILLWEIYSFGR--------------VP---------------YPRI-----PLKDVVPRV----EK----GYK---MDAPDGCP-------------------------------------------PAVYE-VMKNCWHLDAAMRPS-------FL-QLREQL----------------
-----YDTGEELGSGQFAVV---KKCRE---K----------------STGL---QYAA-KFI---KKR--R-TKSSR---R-G-VSREDIEREVSILKEI--Q---HPNVITLHEVYE--N----------KTD--VILILELVAGGELFDFLA--------EKE-----------------------------------------------------------------------------------------------------SL---TEEEATEFLKQILNGVYYLHS--L--------Q---IAHFDLKPENIMLL-D-----RN-VPKP-----RIKIIDFGLAHK------------------IDFGNEF--------------KN---IFGTPEFVAPEI--VN------YEP-LGLEADMWSIGVITYILLS-GA--------------SP---------------FLGD--------TKQETL----AN----VSA---VNYEFEDEYFSNTS-------------------------------------ALAKD-FIRRLLVKDPKKRMT-------IQ-DSLQHPWI--------------
-----YEMGEELGSGQFAIV---RKCRQ---K----------------GTGK---EYAA-KFI---KKR--R-LSSSR---R-G-VSREEIEREVNILREI--R---HPNIITLHDIFE--N----------KTD--VVLILELVSGGELFDFLA--------EKE-----------------------------------------------------------------------------------------------------SL---TEDEATQFLKQILDGVHYLHS--K--------R---IAHFDLKPENIMLL-D-----KN-VPNP-----RIKLIDFGIAHK------------------IEAGNEF--------------KN---IFGTPEFVAPEI--VN------YEP-LGLEADMWSIGVITYILLS-GA--------------SP---------------FLGE--------TKQETL----TN----ISA---VNYDFDEEYFSNTS-------------------------------------ELAKD-FIRRLLVKDPKRRMT-------IA-QSLEHSWI--------------
-----LRFKEKLGEGQFGEV---HLCEV---DSPQDLVSLDFPLNVRKGHPL---LVAV-KIL---R-P--D-AT-KNA-RN-D-FL-K----EVKIMSRL--K---DPNIIRLLGVCV--Q----------DDP--LCMITDYMENGDLNQFLS---------AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQG-PTI---SYPMLLHVAAQIASGMRYLAT--L--------N---FVHRDLATRNCLVG-E-----NF-TI---------KIADFGMSRNL-------------Y---A--GDYY--------------RVQGRAVLPIRWMAWEC--IL------MGK-FTTASDVWAFGVTLWEVLMLCRA-------------QP---------------FGQL-----TDEQVIENAGEFFRD----QGRQVYLSRPPACP-------------------------------------------QGLYE-LMLRCWSRESEQRPP-------FS-QLHRFL----------------
-----LTFKEKLGEGQFGEV---HLCEV---EGMEKFKDKDFALDVSANQPV---LVAV-KML---R-A--D-AN-KNA-RN-D-FL-K----EIKIMSRL--K---DPNIIHLLAVCI--T----------DDP--LCMITEYMENGDLNQFLS---------RHEPPN-----------------------------------------------------------------------------------------SSSSDV-RTV---SYTNLKFMATQIASGMKYLSS--L--------N---FVHRDLATRNCLVG-K-----NY-TI---------KIADFGMSRNL-------------Y---S--GDYY--------------RIQGRAVLPIRWMSWES--IL------LGK-FTTASDVWAFGVTLWETFTFCQE-------------QP---------------YSQL-----SDEQVIENT----GEFFRDQGRQTYLPQPAICP-------------------------------------------DSVYK-LMLSCWRRDTKNRPS-------FQ-EIHL---LL-------------
----F-KKIKVLGSGAFGTV---YKGLW---IP------------EGEKVKI---PVAI-KEL---R-E--A-TS-PKA-NK-E-IL-D----EAYVMASV--D---NPHVCRLLGICL-------------TST--VQLITQLMPFGCLLDYVR---------EH--------------------------------------------------------------------------------------------------K-DNI---GSQYLLNWCVQIAKGMNYLED--R--------R---LVHRDLAARNVLVK-T-----PQ-HV---------KITDFGLAKLL-------------G---A--EEKE--------------YHAEGGKVPIKWMALES--IL------HRI-YTHQSDVWSYGVTVWELMTFGS--------------KP---------------YDGI-----PASEISSIL----EK----GER---LPQPPICT-------------------------------------------IDVYM-IMVKCWMIDADSRPK-------FR-ELI----IEF------------
---LM--VDTVIGEGEFGEV---YRGTL---R-------------LPSQDCK---TVAI-KTL---K-D--T-SP-GGQ-WW-N-FL-R----EATIMGQF--S---HPHILHLEGVVT--K----------RKP--IMIITEFMENGALDAFLR---------ER--------------------------------------------------------------------------------------------------E-DQL---VPGQLVAMLQGIASGMNYLSN--H--------N---YVHRDLAARNILVN-Q-----NL-CC---------KVSDFGLTRLL-------------D---D--FDGT--------------YETQGGKIPIRWTAPEA--IA------HRI-FTTASDVWSFGIVMWEVLSFGD--------------KP---------------YGEM-----SNQEVMKSI----ED----GYR---LPPPVDCP-------------------------------------------APLYE-LMKNCWAYDRARRPH-------FQ-KLQAHL----------------
----I-SIDKVVGAGEFGEV---CSGRL---K-------------LPSKKEI---SVAI-KTL---K-V--G-YT-EKQ-RR-D-FL-G----EASIMGQF--D---HPNIIRLEGVVT--K----------SKP--VMIVTEYMENGSLDSFLR---------KH--------------------------------------------------------------------------------------------------D-AQF---TVIQLVGMLRGIASGMKYLSD--M--------G---YVHRDLAARNILIN-S-----NL-VC---------KVSDFGLSRVL-------------E---D--DPEA-------------AYTTRGGKIPIRWTSPEA--IA------YRK-FTSASDVWSYGIVLWEVMSYGE--------------RP---------------YWEM-----SNQDVIKAV----DE----GYR---LPPPMDCP-------------------------------------------AALYQ-LMLDCWQKDRNNRPK-------FE-QIVSIL----------------
-----IHIEKIIGSGDSGEV---CYGRL---R-------------VPGQRDV---PVAI-KAL---K-A--G-YT-ERQ-RR-D-FL-S----EASIMGQF--D---HPNIIRLEGVVT--R----------GRL--AMIVTEYMENGSLDTFLR---------TH--------------------------------------------------------------------------------------------------D-GQF---TIMQLVGMLRGVGAGMRYLSD--L--------G---YVHRDLAARNVLVD-S-----NL-VC---------KVSDFGLSRVL-------------E---D--DPDA-------------AYTTTGGKIPIRWTAPEA--IA------FRT-FSSASDVWSFGVVMWEVLAYGE--------------RP---------------YWNM-----TNRDVISSV----EE----GYR---LPAPMGCP-------------------------------------------HALHQ-LMLDCWHKDRAQRPR-------FS-QIVSVL----------------
----V-KIEEVIGAGEFGEV---YKGRL---K-------------LPGKREI---YVAI-KTL---K-A--G-YS-EKQ-RR-D-FL-S----EASIMGQF--D---HPNIIRLEGVVT--K----------SRP--VMIITEFMENGALDSFLR---------QN--------------------------------------------------------------------------------------------------D-GQF---TVIQLVGMLRGIAAGMKYLAE--M--------N---YVHRDLAARNILVN-S-----NL-VC---------KVSDFGLSRYLQ----------DDT---S--DPTY--------------TSSLGGKIPVRWTAPEA--IA------YRK-FTSASDVWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDVINAI----EQ----DYR---LPPPMDCP-------------------------------------------AALHQ-LMLDCWQKDRNSRPR-------FA-EIVNTL----------------
----V-KIEQVIGAGEFGEV---CSGHL---K-------------LPGKREI---FVAI-KTL---K-S--G-YT-EKQ-RR-D-FL-S----EASIMGQF--D---HPNVIHLEGVVT--K----------STP--VMIITEFMENGSLDSFLR---------QN--------------------------------------------------------------------------------------------------D-GQF---TVIQLVGMLRGIAAGMKYLAD--M--------N---YVHRDLAARNILVN-S-----NL-VC---------KVSDFGLSRFLE----------DDT---S--DPTY--------------TSALGGKIPIRWTAPEA--IQ------YRK-FTSASDVWSYGIVMWEVMSYGE--------------RP---------------YWDM-----TNQDVINAI----EQ----DYR---LPPPMDCP-------------------------------------------SALHQ-LMLDCWQKDRNHRPK-------FG-QIVNTL----------------
----V-KIEEVIGAGEFGEV---CRGRL---K-------------APGKKES---CVAI-KTL---K-G--G-YT-ERQ-RR-E-FL-S----EASIMGQF--E---HPNIIRLEGVVT--N----------SMP--VMILTEFMENGALDSFLR---------LN--------------------------------------------------------------------------------------------------D-GQF---TVIQLVGMLRGIASGMRYLAE--M--------S---YVHRDLAARNILVN-S-----NL-VC---------KVSDFGLSRFLE----------ENS---S--DPTY--------------TSSLGGKIPIRWTAPEA--IA------FRK-FTSASDAWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDVINAI----EQ----DYR---LPPPPDCP-------------------------------------------TSLHQ-LMLDCWQKDRNARPR-------FP-QVVSAL----------------
-----IKIEEVIGTGSFGEV---RQGRL---Q-------------PRGRREQ---TVAI-QAL---W-A--G-GA-ESL-QM-T-FL-G----RAAVLGQF--Q---HPNILRLEGVVT--K----------SRP--LMVLTEFMELGPLDSFLR---------QR--------------------------------------------------------------------------------------------------E-GQF---SSLQLVAMQRGVAAAMQYLSS--F--------A---FVHRSLSAHSVLVN-S-----HL-VC---------KVARLGHSPQG-------------------------------------------PSCLLRWAAPEV--IA------HGK-HTTSSDVWSFGILMWEVMSYGE--------------RP---------------YWDM-----SEQEVLNAI----EQ----EFR---LPPPPGCP-------------------------------------------PGLHL-LMLDTWQKDRARRPH-------FD-QLVA---AF-------------
----L-RKVKVLGSGAFGTV---YKGIW---IP------------DGENVKI---PVAI-KVL---R-E--N-TS-PKA-NK-E-IL-D----EAYVMAGV--G---SPYVSRLLGICL-------------TST--VQLVTQLMPYGCLLDHVR---------EN--------------------------------------------------------------------------------------------------R-GRL---GSQDLLNWCMQIAKGMSYLED--V--------R---LVHRDLAARNVLVK-S-----PN-HV---------KITDFGLARLL-------------D---I--DETE--------------YHADGGKVPIKWMALES--IL------RRR-FTHQSDVWSYGVTVWELMTFGA--------------KP---------------YDGI-----PAREIPDLL----EK----GER---LPQPPICT-------------------------------------------IDVYM-IMVKCWMIDSECRPR-------FR-ELVSE--F--------------
----L-KRVKVLGSGAFGTV---YKGIW---VP------------EGETVKI---PVAI-KIL---N-E--T-TG-PKA-NV-E-FM-D----EALIMASM--D---HPHLVRLLGVCL-------------SPT--IQLVTQLMPHGCLLEYVH---------EH--------------------------------------------------------------------------------------------------K-DNI---GSQLLLNWCVQIAKGMMYLEE--R--------R---LVHRDLAARNVLVK-S-----PN-HV---------KITDFGLARLL-------------E---G--DEKE--------------YNADGGKMPIKWMALEC--IH------YRK-FTHQSDVWSYGVTIWELMTFGG--------------KP---------------YDGI-----PTREIPDLL----EK----GER---LPQPPICT-------------------------------------------IDVYM-VMVKCWMIDADSRPK-------FK-ELAAE--F--------------
----L-VLGKPLGEGCFGQV---VLAEA---IGL---------DKDKPNRVT---KVAV-KML---K-S--D-AT-EKD-LS-D-LI-S----EMEMMKMIG-K---HKNIINLLGACT--Q----------DGP--LYVIVEYASKGNLREYLQ---------ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPE-EQL---SSKDLVSCAYQVARGMEYLAS--K--------K---CIHRDLAARNVLVT-E-----DN-VM---------KIADFGLARDI-------------H---H--IDYY--------------KKTTNGRLPVKWMAPEA--LF------DRI-YTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGV-----PVEELFKLL----KE----GHR---MDKPSNCT-------------------------------------------NELYM-MMRDCWHAVPSQRPT-------FK-QLVEDL----------------
-----LTLGKPLGEGCFGQV---VMAEA---VGI---------DKDKPKEAV---TVAV-KML---K-D--D-AT-EKD-LS-D-LV-S----EMEMMKMIG-K---HKNIINLLGACT--Q----------DGP--LYVIVEYASKGNLREYLR---------ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPE-EQM---TFKDLVSCTYQLARGMEYLAS--Q--------K---CIHRDLAARNVLVT-E-----NN-VM---------KIADFGLARDI-------------N---N--IDYY--------------KKTTNGRLPVKWMAPEA--LF------DRV-YTHQSDVWSFGVLMWEIFTLGG--------------SP---------------YPGI-----PVEELFKLL----KE----GHR---MDKPANCT-------------------------------------------NELYM-MMRDCWHAVPSQRPT-------FK-QLVEDL----------------
-----LTLGKPLGEGCFGQV---VMAEA---IGI---------DKDRAAKPV---TVAV-KML---K-D--D-AT-DKD-LS-D-LV-S----EMEMMKMIG-K---HKNIINLLGACT--Q----------GGP--LYVLVEYAAKGNLREFLR---------ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPE-EQL---TFKDLVSCAYQVARGMEYLAS--Q--------K---CIHRDLAARNVLVT-E-----DN-VM---------KIADFGLARDV-------------H---N--LDYY--------------KKTTNGRLPVKWMAPEA--LF------DRV-YTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGI-----PVEELFKLL----KE----GHR---MDKPANCT-------------------------------------------HDLYM-IMRECWHAAPSQRPT-------FK-QLVEDL----------------
----L-VLGKPLGEGCFGQV---VRAEA---FGM---------DPARPDQAS---TVAV-KML---K-D--N-AS-DKD-LA-D-LV-S----EMEVMKLIG-R---HKNIINLLGVCT--Q----------EGP--LYVIVECAAKGNLREFLR---------ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSE-GPL---SFPVLVSCAYQVARGMQYLES--R--------K---CIHRDLAARNVLVT-E-----DN-VM---------KIADFGLARGV-------------H---H--IDYY--------------KKTSNGRLPVKWMAPEA--LF------DRV-YTHQSDVWSFGILLWEIFTLGG--------------SP---------------YPGI-----PVEELFSLL----RE----GHR---MDRPPHCP-------------------------------------------PELYG-LMRECWHAAPSQRPT-------FK-QLVEAL----------------
-----LHLGRVLGYGAFGKV---VEASA---FG-----------IHKGSSCD---TVAV-KML---K-E--G-AT-ASE-HR-A-LM-S----ELKILIHIG-N---HLNVVNLLGACT-KP----------QGP--LMVIVEFCKYGNLSNFLR---------AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWL-SPL---TMEDLVCYSFQVARGMEFLAS--R--------K---CIHRDLAARNILLS-E-----SD-VV---------KICDFGLARDI-------------Y---K--DPDY--------------VRKGSARLPLKWMAPES--IF------DKV-YTTQSDVWSFGVLLWEIFSLGA--------------SP---------------YPGV-Q---INEEFCQRL----RD----GTR---MRAPELAT-------------------------------------------PAIRR-IMLNCWSGDPKARPA-------FS-ELVEIL----------------
-----IQLLKRLGSGQFGEV---WEGLW---N-----------------NTT---PVAV-KTL---K-P--G-SM-DP---N-D-FL-R----EAQIMKNL--R---HPKLIQLYAVCT--L----------EDP--IYIITELMRHGSLQEYLQ---------ND-------------------------------------------------------------------------------------------------TG-SKI---HLTQQVDMAAQVASGMAYLES--R--------N---YIHRDLAARNVLVG-E-----HN-IY---------KVADFGLARVFK-----------VD---N--EDIY--------------ESRHEIKLPVKWTAPEA--IR------SNK-FSIKSDVWSFGILLYEIITYGK--------------MP---------------YSGM-----TGAQVIQML----AQ----NYR---LPQPSNCP-------------------------------------------QQFYN-IMLECWNAEPKERPT-------FE-TLRWK--L--------------
-----LQLIKRLGNGQFGEV---WMGTW---N-----------------GNT---KVAI-KTL---K-P--G-TM-SP---E-S-FL-E----EAQIMKKL--K---HDKLVQLYAVVS-------------EEP--IYIVTEYMNKGSLLDFLK---------DG-------------------------------------------------------------------------------------------------EG-RAL---KLPNLVDMAAQVAAGMAYIER--M--------N---YIHRDLRSANILVG-N-----GL-IC---------KIADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEA--AL------YGR-FTIKSDVWSFGILLTELVTKGR--------------VP---------------YPGM-----NNREVLEQV----ER----GYR---MPCPQDCP-------------------------------------------ISLHE-LMIHCWKKDPEERPT-------FE-YLQSFL----------------
-----LKLEKKLGAGQFGEV---WMATY---N-----------------KHT---KVAV-KTM---K-P--G-SM-SV---E-A-FL-A----EANVMKTL--Q---HDKLVKLHAVVT-------------KEP--IYIITEFMAKGSLLDFLK---------SD-------------------------------------------------------------------------------------------------EG-SKQ---PLPKLIDFSAQIAEGMAFIEQ--R--------N---YIHRDLRAANILVS-A-----SL-VC---------KIADFGLARVI-----------------E--DNEY--------------TAREGAKFPIKWTAPEA--IN------FGS-FTIKSDVWSFGILLMEIVTYGR--------------IP---------------YPGM-----SNPEVIRAL----ER----GYR---MPRPENCP-------------------------------------------EELYN-IMMRCWKNRPEERPT-------FE-YIQSV--L--------------
--IGS----RKLGEGSFAKV---REGLH---V----------------LTGE---KVAI-KVI---DKK--R-AKKDT---Y-V-TKNLR--REGQIQQMI--R---HPNITQLLDILE--T----------ENS--YYLVMELCPGGNLMHKIY--------EKK-----------------------------------------------------------------------------------------------------RL---EESEARRYIRQLISAVEHLHR--A--------G---VVHRDLKIENLLLD-E-----DN-NI---------KLIDFGLSNCAG---------------ILGYSDPF--------------ST---QCGSPAYAAPEL--LA------RKK-YGPKIDVWSIGVNMYAMLT-GT--------------LP---------------FTVE------PFSLRALY----QK----MVD----KEMNPLPTQ--LS-------------------------------------TGAIS-FLRSLLEPDPVKRPN-------IQ-QALANRWL--------------
-----YTTIRQLGDGTYGSV---LLGRS---I----------------ESGE---LIAI-KKM---KRK--F-YSWEE---C---MNLR----EVKSLKKL--N---HANVVKLKEVIR--E----------NDH--LYFIFEYMKE-NLYQLIK-------ERNK-----------------------------------------------------------------------------------------------------LF---PESAIRNIMYQILQGLAFIHK--H--------G---FFHRDLKPENLLCM-G-----PE-LV---------KIADFGLARE------------------IRSKPPY--------------TD---YVSTRWYRAPEV--LL-----RSTN-YSSPIDVWAVGCIMAEVYT-LR--------------PL---------------FPGA-----SEIDTIFKI----CQ----VLG---TPKKTDWPEGYQLSSAMNFRWPQCV--------------PNNLKTLIPNASSEAVQ-LLRDMLQWDPKKRPT-------AS-QALRYPYF--------------
-----ITMSRELGQGSFGMV---YEGVA---KG-----------VVKDEPET---RVAI-KTV---N-E--A-AS-MRE-RI-E-FL-N----EASVMKEF--N---CHHVVRLLGVVS--Q----------GQP--TLVIMELMTRGDLKSYLR---------SLRPEM-----------------------------------------------------------------------------------------ENNPVL-APP---SLSKMIQMAGEIADGMAYLNA--N--------K---FVHRDLAARNCMVA-E-----DF-TV---------KIGDFGMTRDI-------------Y---E--TDYY--------------RKGGKGLLPVRWMSPES--LK------DGV-FTTYSDVWSFGVVLWEIATLAE--------------QP---------------YQGL-----SNEQVLRFV----ME----GGL---LDKPDNCP-------------------------------------------DMLFE-LMRMCWQYNPKMRPS-------FL-EIISS--I--------------
-----ITLLRELGQGSFGMV---YEGNA---RD-----------IIKGEAET---RVAV-KTV---N-E--S-AS-LRE-RI-E-FL-N----EASVMKGF--T---CHHVVRLLGVVS--K----------GQP--TLVVMELMAHGDLKSYLR---------SLRPEA-----------------------------------------------------------------------------------------ENNPGR-PPP---TLQEMIQMAAEIADGMAYLNA--K--------K---FVHRDLAARNCMVA-H-----DF-TV---------KIGDFGMTRDI-------------Y---E--TDYY--------------RKGGKGLLPVRWMAPES--LK------DGV-FTTSSDMWSFGVVLWEITSLAE--------------QP---------------YQGL-----SNEQVLKFV----MD----GGY---LDQPDNCP-------------------------------------------ERVTD-LMRMCWQFNPKMRPT-------FL-EIVNLL----------------
----I-SIIRELGQGSFGMV---YEGLA---RG-----------LEAGEEST---PVAL-KTV---N-E--L-AS-PRE-CI-E-FL-K----EASVMKAF--K---CHHVVRLLGVVS--Q----------GQP--TLVIMELMTRGDLKSHLR---------SLRPEA-----------------------------------------------------------------------------------------ENNPGL-PQP---ALGEMIQMAGEIADGMAYLAA--N--------K---FVHRDLAARNCMVS-Q-----DF-TV---------KIGDFGMTRDV-------------Y---E--TDYY--------------RKGGKGLLPVRWMAPES--LK------DGI-FTTHSDVWSFGVVLWEIVTLAE--------------QP---------------YQGL-----SNEQVLKFV----MD----GGV---LEELEGCP-------------------------------------------LQLQE-LMSRCWQPNPRLRPS-------FT-HILD---SI-------------
--VGG----NKMGEGGFGVV---YKGYV---N----------------NTT-----VAV-KKL---AAM--V-DITTE---ELK-QQFD---QEIKVMAKC--Q---HENLVELLGFSS--D----------GDD--LCLVYVYMPNGSLLDRLSC-----LDGTP-----------------------------------------------------------------------------------------------------PL---SWHMRCKIAQGAANGINFLHE--N--------H---HIHRDIKSANILLD-E-----AF-TA---------KISDFGLARASE---------------KFAQTVMT--------------SR---IVGTTAYMAPEA--LR-------GE-ITPKSDIYSFGVVLLEIIT-GL--------------PA---------------VDEH-----REPQLLLDI----KE----EIE---DEEKTIEDYIDKKMNDAD-----------------------------STSVEAMYS-VASQCLHEKKNKRPD-------IK-KVQQ----LLQ-----------
-----LTFVQEIGSGQFGLV---HLGYW---L-----------------NKD---KVAI-KTI---R-E--G-AM-SE---E-D-FI-E----EAEVMMKL--S---HPKLVQLYGVCL--E----------QAP--ICLVFEFMEHGCLSDYLR---------TQ--------------------------------------------------------------------------------------------------R-GLF---AAETLLGMCLDVCEGMAYLEE--A--------C---VIHRDLAARNCLVG-E-----NQ-VI---------KVSDFGMTRFV-----------------L--DDQY--------------TSSTGTKFPVKWASPEV--FS------FSR-YSSKSDVWSFGVLMWEVFSEGK--------------IP---------------YENR-----SNSEVVEDI----ST----GFR---LYKPRLAS-------------------------------------------THVYQ-IMNHCWKERPEDRPA-------FS-RLLRQL----------------
----L-KRIRDLGEGHFGKV---ELCRY---DP------------EGDNTGE---QVAV-KSL---K-P--E-SG-GNH-IA-D-LK-K----EIEILRNL--Y---HENIVKYKGICT-ED-----------GGNGIKLIMEFLPSGSLKEYLP---------KN--------------------------------------------------------------------------------------------------K-NKI---NLKQQLKYAVQICKGMDYLGS--R--------Q---YVHRDLAARNVLVE-S-----EH-QV---------KIGDFGLTKAI------------ET---D--KEYY--------------TVKDDRDSPVFWYAPEC--LM------QSK-FYIASDVWSFGVTLHELLTYCD--------------SDSSPMALF-LKMIGPTHGQM-----TVTRLVNTL----KE----GKR---LPCPPNCP-------------------------------------------DEVYQ-LMRKCWEFQPSNRTS-------FQ-NLIE---GF-------------
-----LKFLQQLGKGNFGSV---EMCRY---DP------------LQDNTGE---VVAV-KKL---Q-H--S-TE--EH-LR-D-FE-R----EIEILKSL--Q---HDNIVKYKGVCYSAG----------RRN--LKLIMEYLPYGSLRDYLQ---------KH--------------------------------------------------------------------------------------------------K-ERI---DHIKLLQYTSQICKGMEYLGT--K--------R---YIHRDLATRNILVE-N-----EN-RV---------KIGDFGLTKVL------------PQ---D--KEYY--------------KVKEPGESPIFWYAPES--LT------ESK-FSVASDVWSFGVVLYELFTYIE--------------KSKSPPAEFMRMIGNDKQGQM-----IVFHLIELL----KN----NGR---LPRPDGCP-------------------------------------------DEIYM-IMTECWNNNVNQRPS-------FR-DLA----LRV------------
----L-KYISQLGKGNFGSV---ELCRY---DP------------LGDNTGA---LVAV-KQL---Q-H--S-GP-DQ--QR-D-FQ-R----EIQILKAL--H---SDFIVKYRGVSYGPG----------RQS--LRLVMEYLPSGCLRDFLQ---------RH--------------------------------------------------------------------------------------------------R-ARL---DASRLLLYSSQICKGMEYLGS--R--------R---CVHRDLAARNILVE-S-----EA-HV---------KIADFGLAKLL------------PL---D--KDYY--------------VVREPGQSPIFWYAPES--LS------DNI-FSRQSDVWSFGVVLYELFTYCD--------------KSCSPSAE--FLRMMGCERDV-P---ALCRLLELL----EE----GQR---LPAPPACP-------------------------------------------AEVHE-LMKLCWAPSPQDRPS-------FS-ALGP---QL-------------
-----LKLGKPLGRGAFGQV---IEADA---FG-----------IDKTATCR---TVAV-KML---K-E--G-AT-HSE-HR-A-LM-S----ELKILIHIG-H---HLNVVNLLGACT-KP----------GGP--LMVIVEFCKFGNLSTYLR---------SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYK-DFL---TLEHLICYSFQVAKGMEFLAS--R--------K---CIHRDLAARNILLS-E-----KN-VV---------KICDFGLARDI-------------Y---K--DPDY--------------VRKGDARLPLKWMAPET--IF------DRV-YTIQSDVWSFGVLLWEIFSLGA--------------SP---------------YPGV-K---IDEEFCRRL----KE----GTR---MRAPDYTT-------------------------------------------PEMYQ-TMLDCWHGEPSQRPT-------FS-ELVEHL----------------
-----YEIDRTIGKGNFAVV---KRATH---L----------------VTKA---KVAI-KII---DKT--Q-LDEEN---L-K-KIFR----EVQIMKML--C---HPHIIRLYQVME--T----------ERM--IYLVTEYASGGEIFDHLV--------AHG-----------------------------------------------------------------------------------------------------RM---AEKEARRKFKQIVTAVYFCHC--R--------N---IVHRDLKAENLLLD-A-----NL-NI---------KIADFGFSNL------------------FTPGQLL--------------KT---WCGSPPYAAPEL--FE-----GKEY-DGPKVDIWSLGVVLYVLVC-GA--------------LP---------------FDGS--------TLQNLR----AR----VLS---GKFRIPFFMS-----------------------------------------TECEH-LIRHMLVLDPNKRLS-------ME-QICKHKWM--------------
-----LSFGKTLGAGAFGKV---VEATA---YG-----------LIKSDAAM---TVAV-KML---K-P--S-AH-LTE-RE-A-LM-S----ELKVLSYLG-N---HMNIVNLLGACT--I----------GGP--TLVITEYCCYGDLLNFLR---------RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDE-LAL---DLEDLLSFSYQVAKGMAFLAS--K--------N---CIHRDLAARNILLT-H-----GR-IT---------KICDFGLARDI-------------K---N--DSNY--------------VVKGNARLPVKWMAPES--IF------NCV-YTFESDVWSYGIFLWELFSLGS--------------SP---------------YPGM-P---VDSKFYKMI----KE----GFR---MLSPEHAP-------------------------------------------AEMYD-IMKTCWDADPLKRPT-------FK-QIVQL--I--------------
-----LKLVERLGAGQFGEV---WMGYY---N-----------------GHT---KVAV-KSL---K-Q--G-SM-SP---D-A-FL-A----EANLMKQL--Q---HQRLVRLYAVVT-------------QEP--IYIITEYMENGSLVDFLK---------TP-------------------------------------------------------------------------------------------------SG-IKL---TINKLLDMAAQIAEGMAFIEE--R--------N---YIHRDLRAANILVS-D-----TL-SC---------KIADFGLARLI-----------------E--DNEY--------------TAREGAKFPIKWTAPEA--IN------YGT-FTIKSDVWSFGILLTEIVTHGR--------------IP---------------YPGM-----TNPEVIQNL----ER----GYR---MVRPDNCP-------------------------------------------EELYQ-LMRLCWKERPEDRPT-------FD-YLRSV--L--------------
---LI--HGEVLGKGCFGQA---IKVTH---R----------------ETGE---VMVM-KEL---I----R-FD-EET-QR-T-FL-K----EVKVMRCL--E---HPNVLKFIGVLY--K----------DKR--LNFITEYIKGGTLRGIIK---------SM--------------------------------------------------------------------------------------------------D-SQY---PWSQRVSFAKDIASGMAYLHS--M--------N---IIHRDLNSHNCLVR-E-----NK-NV---------VVADFGLARLM-------------V---D--EKTQPEGLRS--LKKPDRKKRYTVVGNPYWMAPEM--IN------GRS-YDEKVDVFSFGIVLCEIIGRVN--------------AD---------------PDYL-P---RTMDFGLNV----RG----FLD---RYCPPNCP-------------------------------------------PSFFP-ITVRCCDLDPEKRPS-------FV-KLEH---WL-------------
---LI--HGEVLGKGFFGQA---IKVTH---K-----------------ATG---KVMVMKEL-----I--R-CD-EET-QK-T-FL-T----EVKVMRSL--D---HPNVLKFIGVLY--K----------DKK--LNLLTEYIEGGTLKDFLR---------SM----------------------------------------------------------------------------------------------------DPF---PWQQKVRFAKGIASGMAYLHS--M--------C---IIHRDLNSHNCLIK-L-----DK-TV---------VVADFGLSRLIVEERKRAPMEKATT---------KKRTL-----RKNDRKKRYTVVGNPYWMAPEM--LN------GKS-YDETVDIFSFGIVLCEIIGQVY--------------AD---------------PDCL-P---RTLDFGLNV----KL----FWE---KFVPTDCP-------------------------------------------PAFFP-LAAICCRLEPESRPA-------FS-KLED---SF-------------
----V-TLLRALGHGAFGEV---YEGLV---IG-----------LPGDSSPL---QVAI-KTL---P-E--L-CS-PQD-EL-D-FL-M----EALIISKF--R---HQNIVRCVGLSL--R----------ATP--RLILLELMSGGDMKSFLR---------HSRP--------------------------------------------------------------------------------------------HLGQP-SPL---VMRDLLQLAQDIAQGCHYLEE--N--------H---FIHRDIAARNCLLS-CA--GPSR-VA---------KIGDFGMARDI-------------Y---R--ASYY--------------RRGDRALLPVKWMPPEA--FL------EGI-FTSKTDSWSFGVLLWEIFSLGY--------------MP---------------YPGR-----TNQEVLDFV----VG----GGR---MDPPRGCP-------------------------------------------GPVYR-IMTQCWQHEPELRPS-------FA-SILERL----------------
-----IKLVKRLGAGQFGEV---WMGYY---N-----------------NST---KVAV-KTL---K-P--G-TM-SV---Q-A-FL-E----EANLMKTL--Q---HDKLVRLYAVVT--R----------EEP--IYIITEYMAKGSLLDFLK---------SD-------------------------------------------------------------------------------------------------EG-GKV---LLPKLIDFSAQIAEGMAYIER--K--------N---YIHRDLRAANVLVS-E-----SL-MC---------KIADFGLARVI-----------------E--DNEY--------------TAREGAKFPIKWTAPEA--IN------FGC-FTIKSDVWSFGILLYEIVTYGK--------------IP---------------YPGR-----TNADVMTAL----SQ----GYR---MPRVENCP-------------------------------------------DELYD-IMKMCWKEKAEERPT-------FD-YLQSV--L--------------
-----YTTMRQLGDGTYGSV---LMGKS---N----------------ESGE---LVAI-KRM---KRK--F-YSWDE---C-M--NLR----EVKSLKKL--N---HANVIKLKEVIR--E----------NDH--LYFIFEYMKE-NLYQLMK-------DRNK-----------------------------------------------------------------------------------------------------LF---PESVIRNIMYQILQGLAFIHK--H--------G---FFHRDMKPENLLCM-G-----PE-LV---------KIADFGLARE------------------LRSQPPY--------------TD---YVSTRWYRAPEV--LL-----RSSV-YSSPIDVWAVGSIMAELYM-LR--------------PL---------------FPGT-----SEVDEIFKI----CQ----VLG---TPKKSDWPEGYQLASSMNFRFPQCV--------------PINLKTLIPNASNEAIQ-LMTEMLNWDPKKRPT-------AS-QALKHPYF--------------
-----FEKISELGAGNGGVV---FKVSH---K----------------PSGL----VMA-RKL---IHL--E-IKPAI---R-N-QIIR----ELQVLHEC--N---SPYIVGFYGAFY--S----------DGE--ISICMEHMDGGSLDQVLK--------KAG-----------------------------------------------------------------------------------------------------RI---PEQILGKVSIAVIKGLTYLRE-KH--------K---IMHRDVKPSNILVN-S-----RG-EI---------KLCDFGVSG-------------------QLIDSMA--------------NS---FVGTRSYMSPER--LQ------GTH-YSVQSDIWSMGLSLVEMAV-GR--------------YP---------------IPPP-----DAKELELMF----GC----QVE---GDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQD-FVNKCLIKNPAERAD-------LK-QLMVHAFI--------------
--IRY---RDTLGHGNGGTV---YKAYH---V----------------PSGK---ILAV-KVI---LLD--I-TLELQ---K-Q-I-MS----ELEILYKC--D---SSYIIGFYGAFF--V----------ENR--ISICTEFMDGGSLD------------VYR-----------------------------------------------------------------------------------------------------KM---PEHVLGRIAVAVVKGLTYLWS--L--------K---ILHRDVKPSNMLVN-T-----RG-QV---------KLCDFGVST-------------------QLVNSIA--------------KT---YVGTNAYMAPER--IS------GEQ-YGIHSDVWSLGISFMELAL-GR--------------FP---------------YPQI-----QKNQGSLMP----LQ----LLQ---CIVDEDSPVLPVGEF-----------------------------------SEPFVH-FITQCMRKQPKERPA-------PE-ELMGHPFI--------------
-----IEVEEVVGRGAFGVV---CKAKW---R------------------AK---DVAI-KQI---E-------S-ESE-RK-A-FI-V----ELRQLSRV--N---HPNIVKLYGACL--------------NP--VCLVMEYAEGGSLYNVLH---------GA-------------------------------------------------------------------------------------------------EPLPYY---TAAHAMSWCLQCSQGVAYLHS--M--------QPKALIHRDLKPPNLLLV-A-----GGTVL---------KICDFGTACDI-----------------------Q--------------THMTNNKGSAAWMAPEV--FE------GSN-YSEKCDVFSWGIILWEVITR-R--------------KP---------------FDEIGG---PAFRIMWAV----HN----GTR---PPLIKNLP-------------------------------------------KPIES-LMTRCWSKDPSQRPS-------ME-EIVKI--M--------------
-----FELIQRIGSGTYGDV---YKARN---V----------------NTGE---LAAI-KVI---KLE--P-GEDFA---V-V-Q--Q----EIIMMKDC--K---HPNIVAYFGSYL--R----------RDK--LWICMEFCGGGSLQDIYH--------VTG-----------------------------------------------------------------------------------------------------PL---SELQIAYVSRETLQGLYYLHS--K--------G---KMHRDIKGANILLT-D-----NG-HV---------KLADFGVSAQI-----------------TATIAKR--------------KS---FIGTPYWMAPEVAAVE-----RKGG-YNQLCDLWAVGITAIELAE-LQ--------------PP---------------MFDL-----HPMRALFLM----TK----SNF---QPP--KLKDKMKWS-------------------------------------NSFHH-FVKMALTKNPKKRPT-------AE-KLLQHPFV--------------
-----FELVEVVGNGTYGQV---YKGRH---V----------------KTGQ---LAAI-KVM---DVT--E-DEEEE---I-K-L-------EINMLKKY-SH---HRNIATYYGAFI--KKSP----PGHDDQ--LWLVMEFCGAGSITDLVKN------TKGN-----------------------------------------------------------------------------------------------------TL---KEDWIAYISREILRGLAHLHI--H--------H---VIHRDIKGQNVLLT-E-----NA-EV---------KLVDFGVSAQL-----------------DRTVGRR--------------NT---FIGTPYWMAPEV--IACD-ENPDAT-YDYRSDLWSCGITAIEMAE-GA--------------PP---------------LCDM-----HPMRALFLI----PR----NPP---PRLKSKKWS------------------------------------------KKFFS-FIEGCLVKNYMQRPS-------TE-QLLKHPFI--------------
-----YQNLSPVGSGAYGSV---CAAFD---T----------------KTGL---RVAV-KKL---SRP--F-QSIIH---A-K-RTYR----ELRLLKHM--K---HENVIGLLDVFT--PARS----LEEFND--VYLVTHLMGA-DLNNIVK---------CQ-----------------------------------------------------------------------------------------------------KL---TDDHVQFLIYQILRGLKYIHS--A--------D---IIHRDLKPSNLAVN-E-----DC-EL---------KILDFGLAR--------------------HTDDEM--------------TG---YVATRWYRAPEI--ML-----NWMH-YNQTVDIWSVGCIMAELLT-GR--------------TL---------------FPGT-----DHIDQLKLI----LR----LVG---TPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVD-LLEKMLVLDSDKRIT-------AA-QALAHAYF--------------
-----YRLLKTIGKGNFAKV---KLARH---I----------------LTGK---EVAV-KII---DKT--Q-LNSSS---L-Q-KLFR----EVRIMKVL--N---HPNIVKLFEVIE--T----------EKT--LYLVMEYASGGEVFDYLV--------AHG-----------------------------------------------------------------------------------------------------RM---KEKEARAKFRQIVSAVQYCHQ--K--------F---IVHRDLKAENLLLD-A-----DM-NI---------KIADFGFSNE------------------FTFGNKL--------------DT---FCGSPPYAAPEL--FQ-----GKKY-DGPEVDVWSLGVILYTLVS-GS--------------LP---------------FDGQ--------NLKELR----ER----VLR---GKYRIPFYMS-----------------------------------------TDCEN-LLKKFLILNPSKRGT-------LE-QIMKDRWM--------------
-----YRLLRTIGKGNFAKV---KLARH---I----------------LTGR---EVAI-KII---DKT--Q-LNPSS---L-Q-KLFR----EVRIMKGL--N---HPNIVKLFEVIE--T----------EKT--LYLVMEYASAGEVFDYLV--------SHG-----------------------------------------------------------------------------------------------------RM---KEKEARAKFRQIVSAVHYCHQ--K--------N---IVHRDLKAENLLLD-A-----EA-NI---------KIADFGFSNE------------------FTLGSKL--------------DT---FCGSPPYAAPEL--FQ-----GKKY-DGPEVDIWSLGVILYTLVS-GS--------------LP---------------FDGH--------NLKELR----ER----VLR---GKYRVPFYMS-----------------------------------------TDCES-ILRRFLVLNPAKRCT-------LE-QIMKDKWI--------------
-----LTLGAQIGEGEFGAV---LQGEY---L------------------GQ---KVAV-KNI---K-C--D-VT-AQ-----A-FL-D----ETAVMTKM--Q---HENLVRLLGVIL-------------HQG--LYIVMEHVSKGNLVNFLR---------TR-------------------------------------------------------------------------------------------------GR-ALV---NTAQLLQFSLHVAEGMEYLES--K--------K---LVHRDLAARNILVS-E-----DL-VA---------KVSDFGLAKAE-----------------------R--------------KGLDSSRLPVKWTAPEA--LK------HGK-FTSKSDVWSFGVLLWEVFSYGR--------------AP---------------YPKM-----SLKEVSEAV----EK----GYR---MEPPEGCP-------------------------------------------GPVHV-LMSSCWEAEPARRPP-------FR-KLAEKL----------------
-----YELHETIGTGGFAKV---KLACH---I----------------LTGE---MVAI-KIM---DKN--T-LGSDL---P-R-IKT-----EIEALKNL--R---HQHICQLYHVLE--T----------ANK--IFMVLEYCPGGELFDYII--------SQD-----------------------------------------------------------------------------------------------------RL---SEEETRVVFRQIVSAVAYVHS--Q--------G---YAHRDLKPENLLFD-E-----YH-KL---------KLIDFGLCAKP----------------KGNKDYHL--------------QT---CCGSLAYAAPEL--IQ-----GKSY-LGSEADVWSMGILLYVLMC-GF--------------LP---------------FDDD--------NVMALY----KK----IMR---GKYDVPKWLS-----------------------------------------PSSIL-LLQQMLQVDPKKRIS-------MK-NLLNHPWI--------------
-----VHFNEVIGRGHFGCV---YHGTL---L-------------DNDGKKI---HCAV-KSL---N-R--I-TD-IGE-VS-Q-FL-T----EGIIMKDF--S---HPNVLSLLGICL-RS----------EGS--PLVVLPYMKHGDLRNFIR---------NE--------------------------------------------------------------------------------------------------T-HNP---TVKDLIGFGLQVAKGMKYLAS--K--------K---FVHRDLAARNCMLD-E-----KF-TV---------KVADFGLARDM-------------Y---D--KEYYS------------VHNKTGAKLPVKWMALES--LQ------TQK-FTTKSDVWSFGVLLWELMTRGA--------------PP---------------YPDV-----NTFDITVYL----LQ----GRR---LLQPEYCP-------------------------------------------DPLYE-VMLKCWHPKAEMRPS-------FS-ELVSR--I--------------
-----YRIRGEIGSGNFSQV---KLGIH---S----------------LTKE---KVAI-KIL---DKT--K-LDQKT---Q-R-LLSR----EISSMEKL--H---HPNIIRLYEVVE--T----------LSK--LHLVMEYAGGGELFGKIS--------TEG-----------------------------------------------------------------------------------------------------KL---SEPESKLIFSQIVSAVKHMHE--N--------Q---IIHRDLKAENVFYT-S-----NT-CV---------KVGDFGFSTV------------------SKKGEML--------------NT---FCGSPPYAAPEL--FR-----DEHY-IGIYVDIWALGVLLYFMVT-GT--------------MP---------------FRAE--------TVAKLK----KS----ILE---GTYSVPPHV----S-------------------------------------EPCHR-LIRGVLQQIPTERYG-------ID-CIMNDEWM--------------
-----FELVEVVGNGTYGQV---YKGRH---V----------------KTGQ---LAAI-KVM---DVT--E-DEEEE---I-K-Q-------EINMLKKY-SH---HRNIATYYGAFI--KKSP----PGNDDQ--LWLVMEFCGAGSVTDLVKN------TKGN-----------------------------------------------------------------------------------------------------AL---KEDCIAYICREILRGLAHLHA--H--------K---VIHRDIKGQNVLLT-E-----NA-EV---------KLVDFGVSAQL-----------------DRTVGRR--------------NT---FIGTPYWMAPEV--IACD-ENPDAT-YDYRSDIWSLGITAIEMAE-GA--------------PP---------------LCDM-----HPMRALFLI----PR----NPP---PRLKSKKWS------------------------------------------KKFID-FIDTCLIKTYLSRPP-------TE-QLLKFPFI--------------
----I-EYVRDIGEGAFGRV---FQARA---PG-----------LLPYEPFT---MVAV-KML---K-E--E-AS-ADM-QA-D-FQ-R----EAALMAEF--D---NPNIVKLLGVCA--V----------GKP--MCLLFEYMAYGDLNEFLR---------SMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGP-PPL---SCAEQLCIARQVAAGMAYLSE--R--------K---FVHRDLATRNCLVG-E-----NM-VV---------KIADFGLSRNI-------------Y---S--ADYY--------------KANENDAIPIRWMPPES--IF------YNR-YTTESDVWAYGVVLWEIFSYGL--------------QP---------------YYGM-----AHEEVIYYV----RD----GNI---LSCPENCP-------------------------------------------VELYN-LMRLCWSKLPADRPS-------FT-SIHRIL----------------
-----WEITETIGKGTYGKV---FKVLN---K----------------KNGQ---KAAV-KIL---DPI--H-DIDEE---I-E-A-------EYNILKAL-SD---HPNVVRFYGIYF--KKD-----KVNGDK--LWLVLELCSGGSVTDLVKGF----LKRGE-----------------------------------------------------------------------------------------------------RM---SEPLIAYILHEALMGLQHLHN--N--------K---TIHRDVKGNNILLT-T-----EG-GV---------KLVDFGVSAQL-----------------TSTRHRR--------------NT---SVGTPFWMAPEV--IACE-QQLDTT-YDARCDTWSLGITAIELGD-GD--------------PP---------------LADL-----HPMRALFKI----PR----NPP---PKLRQPELWS-----------------------------------------AEFND-FISKCLTKDYEKRPT-------VS-ELLQHKFI--------------
----Y-VRLQKIGEGSFGKA---ILVKS---T----------------EDGR---QYVI-KEI---NIS--R-MSSKE---R-E-ESRR----EVAVLANM--K---HPNIVQYRESFE--E----------NGS--LYIVMDYCEGGDLFKRINA------QKGV-----------------------------------------------------------------------------------------------------LF---QEDQILDWFVQICLALKHVHD--R--------K---ILHRDIKSQNIFLT-K-----DG-TV---------QLGDFGIARVL-----------------NSTVELA--------------RT---CIGTPYYLSPEI--CE------NKP-YNNKSDIWALGCVLYELCT-LK--------------HA---------------FEAG--------SMKNLV----LK----IIS---GSFPPVSLHYS----------------------------------------YDLRS-LVSQLFKRNPRDRPS-------VN-SILEKGF-I-------------
-----YEVLYTIGTGSYGRC---QKIRR---K----------------SDGK---ILVW-KEL---DYG--S-MTEAE---K-Q-MLVS----EVNLLREL--K---HPNIVRYYDRII--DR--------TNTT--LYIVMEYCEGGDLASVITKG----TKERQ-----------------------------------------------------------------------------------------------------YL---DEEFVLRVMTQLTLALKECHR--RSD---GGHT---VLHRDLKPANVFLD-G-----KQ-NV---------KLGDFGLARIL-----------------NHDTSFA--------------KT---FVGTPYYMSPEQ--MN------RMS-YNEKSDIWSLGCLLYELCA-LM--------------PP---------------FTAF--------SQKELA----GK----IRE---GKFRRIPYRY---S-------------------------------------DELNE-IITRMLNLKDYHRPS-------VE-EILENPL-I-------------
----Y-CYLRVVGKGSYGEV---TLVKH---R----------------RDGK---QYVI-KKL---NLR--N-ASSRE---R-R-AAEQ----EAQLLSQL--K---HPNIVTYKESWE--G---------GDGL--LYIVMGFCEGGDLYRKLKE------QKGQ-----------------------------------------------------------------------------------------------------LL---PENQVVEWFVQIAMALQYLHE--K--------H---ILHRDLKTQNVFLT-R-----TN-II---------KVGDLGIARVL-----------------ENHCDMA--------------ST---LIGTPYYMSPEL--FS------NKP-YNYKSDVWALGCCVYEMAT-LK--------------HA---------------FNAK--------DMNSLV----YR----IIE---GKLPPMPRDY---S-------------------------------------PELAE-LIRTMLSKRPEERPS-------VR-SILRQPYI--------------
-----YDVIKAIGQGAFGKA---YLAKG---K----------------SDSK---HCVI-KEI---NFE--K-MPIQE---K-E-ASKK----EVILLEKM--K---HPNIVAFFNSFQ--E----------NGR--LFIVMEYCDGGDLMKRINR------QRGV-----------------------------------------------------------------------------------------------------LF---SEDQILGWFVQISLGLKHIHD--R--------K---ILHRDIKAQNIFLS-K-----NG-MV--------AKLGDFGIARVL-----------------NNSMELA--------------RT---CIGTPYYLSPEI--CQ------NKP-YNNKTDIWSLGCVLYELCT-LK--------------HP---------------FEGN--------NLQQLV----LK----ICQ---AHFAPISPGF---S-------------------------------------RELHS-LISQLFQVSPRDRPS-------IN-SILKRPFL--------------
-----YERIRVVGRGAFGIV---HLCLR---K----------------ADQK---LVII-KQI---PVE--Q-MTKEE---R-Q-AAQN----ECQVLKLL--N---HPNVIEYYENFL--E----------DKA--LMIAMEYAPGGTLAEFIQK------RCNS-----------------------------------------------------------------------------------------------------LL---EEETILHFFVQILLALHHVHT--H--------L---ILHRDLKTQNILLDKH-----RM-VV---------KIGDFGISKI------------------LSSKSKA--------------YT---VVGTPCYISPEL--CE------GKP-YNQKSDIWALGCVLYELAS-LK--------------RA---------------FEAA--------NLPALV----LK----IMS---GTFAPISDRY---S-------------------------------------PELRQ-LVLSLLSLEPAQRPP-------LS-HIMAQP--LC------------
--YIP---IRVLGRGAFGEA---TLYRR---T----------------EDDS---LVVW-KEV---DLT--R-LSEKE---R-R-DALN----EIVILALL--Q---HDNIIAYYNHFM--D----------NTT--LLIELEYCNGGNLYDKILR------QKDK-----------------------------------------------------------------------------------------------------LF---EEEMVVWYLFQIVSAVSCIHK--A--------G---ILHRDIKTLNIFLT-K-----AN-LI---------KLGDYGLAKKL-----------------NSEYSMA--------------ET---LVGTPYYMSPEL--CQ------GVK-YNFKSDIWAVGCVIFELLT-LK--------------RT---------------FDAT--------NPLNLC----VK----IVQ---GIRAMEVDSS-QYS-------------------------------------LELIQ-MVHSCLDQDPEQRPT-------AD-ELLDRPL-L-------------
---IV--LKWELGEGAFGKV---FLAEC---HN-----------LLPEQDKM---LVAV-KAL---K-E--A-SE-SA--RQ-D-FQ-R----EAELLTML--Q---HQHIVRFFGVCT--E----------GRP--LLMVFEYMRHGDLNRFLR---------SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAP-GPL---GLGQLLAVASQVAAGMVYLAG--L--------H---FVHRDLATRNCLVG-Q-----GL-VV---------KIGDFGMSRDI-------------Y---S--TDYY--------------RVGGRTMLPIRWMPPES--IL------YRK-FTTESDVWSFGVVLWEIFTYGK--------------QP---------------WYQL-----SNTEAIDCI----TQ----GRE---LERPRACP-------------------------------------------PEVYA-IMRGCWQREPQQRHS-------IK-DVHARL----------------
----I-VLKRELGEGAFGKV---FLAEC---YN-----------LCPEQDKI---LVAV-KTL---K-D--A-SD-NA--RK-D-FH-R----EAELLTNL--Q---HEHIVKFYGVCV--E----------GDP--LIMVFEYMKHGDLNKFLR---------AHGPDAV--------------------------------------------------------------------------------------LMAEGNPP-TEL---TQSQMLHIAQQIAAGMVYLAS--Q--------H---FVHRDLATRNCLVG-E-----NL-LV---------KIGDFGMSRDV-------------Y---S--TDYY--------------RVGGHTMLPIRWMPPES--IM------YRK-FTTESDVWSLGVVLWEIFTYGK--------------QP---------------WYQL-----SNNEVIECI----TQ----GRV---LQRPRTCP-------------------------------------------QEVYE-LMLGCWQREPHMRKN-------IK-GIHTL--L--------------
----I-VLKRELGEGAFGKV---FLAEC---YN-----------LSPTKDKM---LVAV-KAL---K-D--P-TL-AA--RK-D-FQ-R----EAELLTNL--Q---HEHIVKFYGVCG--D----------GDP--LIMVFEYMKHGDLNKFLR---------AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAK-GEL---GLSQMLHIASQIASGMVYLAS--Q--------H---FVHRDLATRNCLVG-A-----NL-LV---------KIGDFGMSRDV-------------Y---S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPES--IM------YRK-FTTESDVWSFGVILWEIFTYGK--------------QP---------------WFQL-----SNTEVIECI----TQ----GRV---LERPRVCP-------------------------------------------KEVYD-VMLGCWQREPQQRLN-------IK-EIYKIL----------------
-----YELQETLGKGTYGKV---KRATE---R----------------FSGR---VVAI-KSI---RKD--K-IKDEQ---D-M-VHIR---REIEIMSSL--N---HPHIISIYEVFE--N----------KDK--IVIIMEYASKGELYDYIS--------ERR-----------------------------------------------------------------------------------------------------RL---SERETRHFFRQIVSAVHYCHK--N--------G---VVHRDLKLENILLD-D-----NC-NI---------KIADFGLSNL------------------YQKDKFL--------------QT---FCGSPLYASPEI--VN-----GRPY-RGPEVDSWALGVLLYTLVY-GT--------------MP---------------FDGF--------DHKNLI----RQ----ISS---GEYREPTQP------------------------------------------SDARG-LIRWMLMVNPDRRAT-------IE-DIANHWW-V-------------
-----YEFLETLGKGTYGKV---KKARE---S----------------SGR----LVAI-KSI---RKD--K-IKDEQ---D-L-MHIR---REIEIMSSL--N---HPHIIAIHEVFE--N----------SSK--IVIVMEYASRGDLYDYIS--------ERQ-----------------------------------------------------------------------------------------------------QL---SEREARHFFRQIVSAVHYCHQ--N--------R---VVHRDLKLENILLD-A-----NG-NI---------KIADFGLSNL------------------YHQGKFL--------------QT---FCGSPLYASPEI--VN-----GKPY-TGPEVDSWSLGVLLYILVH-GT--------------MP---------------FDGH--------DHKILV----KQ----ISN---GAYREPPK-----P-------------------------------------SDACG-LIRWLLMVNPTRRAT-------LE-DVASHWW-V-------------
-----YELQEVIGSGATAVV---QAAYC---A----------------PKKE---KVAI-KRI---NLE--K-CQTSM---D-E--LLK----EIQAMSQC--H---HPNIVSYYTSFV--V----------KDE--LWLVMKLLSGGSVLDIIKHIVAKGEHKSG-----------------------------------------------------------------------------------------------------VL---DESTIATILREVLEGLEYLHK--N--------G---QIHRDVKAGNILLG-E-----DG-SV---------QIADFGVSAFLAT------------GGDITRNKVR--------------KT---FVGTPCWMAPEV--ME-----QVRG-YDFKADIWSFGITAIELAT-GA--------------AP---------------YHKY-----PPMKVLMLT----LQ----NDP---PSLETGVQDKE--MLK--------------------------------KYGKSFRK-MISLCLQKDPEKRPT-------AA-ELLRHKFF--------------
----L-VLGRVLGSGAFGKV---VEGTA---YG-----------LSRSQPVM---KVAV-KML---K-P--T-AR-SSE-KQ-A-LM-S----ELKIMTHLG-P---HLNIVNLLGACT--K----------SGP--IYIITEYCFYGDLVNYLH---------KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNS-EGL---TLLDLLSFTYQVARGMEFLAS--K--------N---CVHRDLAARNVLLA-Q-----GK-IV---------KICDFGLARDI-------------M---H--DSNY--------------VSKGSTFLPVKWMAPES--IF------DNL-YTTLSDVWSYGILLWEIFSLGG--------------TP---------------YPGM-M---VDSTFYNKI----KS----GYR---MAKPDHAT-------------------------------------------SEVYE-IMVKCWNSEPEKRPS-------FY-HLSE---IV-------------
----L-VLGRTLGSGAFGQV---VEATA---HG-----------LSHSQATM---KVAV-KML---K-S--T-AR-SSE-KQ-A-LM-S----ELKIMSHLG-P---HLNVVNLLGACT--K----------GGP--IYIITEYCRYGDLVDYLH---------RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINES-PVL---SYMDLVGFSYQVANGMEFLAS--K--------N---CVHRDLAARNVLIC-E-----GK-LV---------KICDFGLARDI-------------M---R--DSNY--------------ISKGSTFLPLKWMAPES--IF------NSL-YTTLSDVWSFGILLWEIFTLGG--------------TP---------------YPEL-P---MNEQFYNAI----KR----GYR---MAQPAHAS-------------------------------------------DEIYE-IMQKCWEEKFEIRPP-------FS-QLVL---LL-------------
----F-KFGKILGEGSFSTV---VLARE---L----------------ATSR---EYAI-KIL---EKR--H-IIKEN---K-VPYVTR----ERDVMSRL--D---HPFFVKLYFTFQ--D----------DEK--LYFGLSYAKNGELLKYIR--------KIG-----------------------------------------------------------------------------------------------------SF---DETCTRFYTAEIVSALEYLHG--K--------G---IIHRDLKPENILLN-E-----DM-HI---------QITDFGTAKVLS---------------PESKQARA--------------NS---FVGTAQYVSPEL--LT------EKS-ACKSSDLWALGCIIYQLVA-GL--------------PP---------------FRAG--------NEYLIF----QK----IIK---LEYDFPEKFF-----------------------------------------PKARD-LVEKLLVLDATKRLG-------CE-EM------EGYGPLKAHPF---
----F-KFLAVLGRGHFGKV---LLSEF---R----------------PSGE---LFAI-KAL---KKG--D-IVARD---E-V-ESLM---CEKRILAAV--TSAGHPFLVNLFGCFQ--T----------PEH--VCFVMEYSAGGDLMLHIH---------SD-----------------------------------------------------------------------------------------------------VF---SEPRAIFYSACVVLGLQFLHE--H--------K---IVYRDLKLDNLLLD-T-----EG-YV---------KIADFGLCKEG-----------------MGYGDRT--------------ST---FCGTPEFLAPEV--LT------DTS-YTRAVDWWGLGVLLYEMLV-GE--------------SP---------------FPGD--------DEEEVF----DS----IVN---DEVRYPRFLS-----------------------------------------AEAIG-IMRRLLRRNPERRLGSS--ERDAE-DVKKQPFF--------------
---FR--CCAVLGRGHFGKV---LLAEY---K----------------NTNE---MFAI-KAL---KKG--D-IVARD---E-V-DSLM---CEKRIFETV--NSVRHPFLVNLFACFQ--T----------KEH--VCFVMEYAAGGDLMMHIH---------TD-----------------------------------------------------------------------------------------------------VF---SEPRAVFYAACVVLGLQYLHE--H--------K---IVYRDLKLDNLLLD-T-----EG-FV---------KIADFGLCKEG-----------------MGYGDRT--------------ST---FCGTPEFLAPEV--LT------ETS-YTRAVDWWGLGVLIYEMLV-GE--------------SP---------------FPGD--------DEEEVF----DS----IVN---DEVRYPRFLS-----------------------------------------TEAIS-IMRRLLRRNPERRLGAS--EKDAE-DVKKHPFF--------------
----Y-CRGKVLGKGGFAKC---YEMTD---L----------------TNNK---VYAA-KII---PHS--R-VAKPH---Q-R-EKID---KEIELHRIL--H---HKHVVQFYHYFE--D----------KEN--IYILLEYCSRRSMAHILK--------ARK-----------------------------------------------------------------------------------------------------VL---TEPEVRYYLRQIVSGLKYLHE--Q--------E---ILHRDLKLGNFFIN-E-----AM-EL---------KVGDFGLAARL-----------------EPLEHRR--------------RT---ICGTPNYLSPEV--LN------KQG-HGCESDIWALGCVMYTMLL-GR--------------PP---------------FETT--------NLKETY----RC----IRE---ARYTMPSSLL-----------------------------------------APAKH-LIASMLSKNPEDRPS-------LD-DIIRHDFF--------------
---YL--KGRLLGKGGFARC---YEATD---T----------------ETGS---AYAV-KVI---PQS--R-VAKPH---Q-R-EKIL---NEIELHRDL--Q---HRHIVRFSHHFE--D----------ADN--IYIFLELCSRKSLAHIWK--------ARH-----------------------------------------------------------------------------------------------------TL---LEPEVRYYLRQILSGLKYLHQ--R--------G---ILHRDLKLGNFFIT-E-----NM-EL---------KVGDFGLAARL-----------------EPPEQRK--------------KT---ICGTPNYVAPEV--LL------RQG-HGPEADVWSLGCVMYTLLC-GS--------------PP---------------FETA--------DLKETY----RC----IKQ---VHYTLPASLS-----------------------------------------LPARQ-LLAAILRASPRDRPS-------ID-QILRHDFF--------------
----F-KVGNLLGKGSFAGV---YRAES---I----------------HTGL---EVAI-KMI---DKK--A-MYKAG---M-V-QRVQ---NEVKIHCQL--K---HPSILELYNYFE--D----------SNY--VYLVLEMCHNGEMNRYLK-------NRVK-----------------------------------------------------------------------------------------------------PF---SENEARHFMHQIITGMLYLHS--H--------G---ILHRDLTLSNLLLT-R-----NM-NI---------KIADFGLATQL-----------------KMPHEKH--------------YT---LCGTPNYISPEI--AT------RSA-HGLESDVWSLGCMFYTLLI-GR--------------PP---------------FDTD--------TVKNTL----NK----VVL---ADYEMPSFLS-----------------------------------------IEAKD-LIHQLLRRNPADRLS-------LS-SVLDHPFM--------------
----Y-ILGDTLGVGTFGKV---KVGKH---E----------------LTGH---KVAV-KIL---NRQ--K-IRSLD---V-V-GKIR---REIQNLKLF--R---HPHIIKLYQVIS--T----------PSD--IFMVMEYVSGGELFDYIC--------KNG-----------------------------------------------------------------------------------------------------RL---DEKESRRLFQQILSGVDYCHR--H--------M---VVHRDLKPENVLLD-A-----HM-NA---------KIADFGLSNM------------------MSDGEFL--------------RT---SCGSPNYAAPEV--IS-----GRLY-AGPEVDIWSSGVILYALLC-GT--------------LP---------------FDDD--------HVPTLF----KK----ICD---GIFYTPQYLN-----------------------------------------PSVIS-LLKHMLQVDPMKRAT-------IK-DIREHEWF--------------
-----YVLGDTLGVGTFGKV---KIGEH---Q----------------LTGH---KVAV-KIL---NRQ--K-IRSLD---V-V-GKIK---REIQNLKLF--R---HPHIIKLYQVIS--T----------PTD--FFMVMEYVSGGELFDYIC--------KHG-----------------------------------------------------------------------------------------------------RV---EEMEARRLFQQILSAVDYCHR--H--------M---VVHRDLKPENVLLD-A-----HM-NA---------KIADFGLSNM------------------MSDGEFL--------------RT---SCGSPNYAAPEV--IS-----GRLY-AGPEVDIWSCGVILYALLC-GT--------------LP---------------FDDE--------HVPTLF----KK----IRG---GVFYIPEYLN-----------------------------------------RSVAT-LLMHMLQVDPLKRAT-------IK-DIREHEWF--------------
----F-ERIKTLGTGSFGRV---MLVKH---K----------------ETGN---HYAM-KIL---DKQ--K-VVKLK---Q-I-EHTL---NEKRILQAV--N---FPFLVKLEFSFK--D----------NSN--LYMVMEYVPGGEMFSHLR--------RIG-----------------------------------------------------------------------------------------------------RF---SEPHARFYAAQIVLTFEYLHS--L--------D---LIYRDLKPENLLID-Q-----QG-YI---------QVTDFGFAK--------------------RVKGRT--------------WT---LCGTPEYLAPEI--IL------SKG-YNKAVDWWALGVLIYEMAA-GY--------------PP---------------FFAD--------QPIQIY----EK----IVS---GKVRFPSHFS-----------------------------------------SDLKD-LLRNLLQVDLTKRFGNL--KNGVN-DIKNHKWF--------------
----F-ERKKTLGTGSFGRV---MLVKH---K----------------ATEQ---YYAM-KIL---DKQ--K-VVKLK---Q-I-EHTL---NEKRILQAV--N---FPFLVRLEYAFK--D----------NSN--LYMVMEYVPGGEMFSHLR--------RIG-----------------------------------------------------------------------------------------------------RF---SEPHARFYAAQIVLTFEYLHS--L--------D---LIYRDLKPENLLID-H-----QG-YI---------QVTDFGFAK--------------------RVKGRT--------------WT---LCGTPEYLAPEI--IL------SKG-YNKAVDWWALGVLIYEMAA-GY--------------PP---------------FFAD--------QPIQIY----EK----IVS---GKVRFPSHFS-----------------------------------------SDLKD-LLRNLLQVDLTKRFGNL--KNGVS-DIKTHKWF--------------
-----FERLRTLGMGSFGRV---MLVRH---Q----------------ETGG---HYAM-KIL---NKQ--K-VVKMK---Q-V-EHIL---NEKRILQAI--D---FPFLVKLQFSFK--D----------NSY--LYLVMEYVPGGEMFSRLQ--------RVG-----------------------------------------------------------------------------------------------------RF---SEPHACFYAAQVVLAVQYLHS--L--------D---LIHRDLKPENLLID-Q-----QG-YL---------QVTDFGFAK--------------------RVKGRT--------------WT---LCGTPEYLAPEI--IL------SKG-YNKAVDWWALGVLIYEMAV-GF--------------PP---------------FYAD--------QPIQIY----EK----IVS---GRVRFPSKLS-----------------------------------------SDLKH-LLRSLLQVDLTKRFGNL--RNGVG-DIKNHKWF--------------
----F-NFLMVLGKGSFGKV---MLADR---K----------------GTEE---LYAI-KIL---KKD--V-VIQDD---D-V-ECTM---VEKRVLALL-DK---PPFLTQLHSCFQ--T----------VDR--LYFVMEYVNGGDLMYHIQ--------QVG-----------------------------------------------------------------------------------------------------KF---KEPQAVFYAAEISIGLFFLHK--R--------G---IIYRDLKLDNVMLD-S-----EG-HI---------KIADFGMCKEH-----------------MMDGVTT--------------RT---FCGTPDYIAPEI--IA------YQP-YGKSVDWWAYGVLLYEMLA-GQ--------------PP---------------FDGE--------DEDELF----QS----IME---HNVSYPKSLS-----------------------------------------KEAVS-VCKGLMTKHPAKRLG-------C----------GPEGERDVREHAFF
----F-NFLMVLGKGSFGKV---MLSER---K----------------GTDE---LYAV-KIL---KKD--V-VIQDD---D-V-ECTM---VEKRVLALP-GK---PPFLTQLHSCFQ--T----------MDR--LYFVMEYVNGGDLMYHIQ--------QVG-----------------------------------------------------------------------------------------------------RF---KEPHAVFYAAEIAIGLFFLQS--K--------G---IIYRDLKLDNVMLD-S-----EG-HI---------KIADFGMCKEN-----------------IWDGVTT--------------KT---FCGTPDYIAPEI--IA------YQP-YGKSVDWWAFGVLLYEMLA-GQ--------------AP---------------FEGE--------DEDELF----QS----IME---HNVAYPKSMS-----------------------------------------KEAVA-ICKGLMTKHPGKRLG-------C----------GPEGERDIKEHAFF
---FI--FHKVLGKGSFGKV---LLGEL---K----------------GRGE---YFAI-KAL---KKD--V-VLIDD---D-V-ECTM---VEKRVLTLA-AE---NPFLTHLICTFQ--T----------KDH--LFFVMEFLNGGDLMYHIQ--------DKG-----------------------------------------------------------------------------------------------------RF---ELYRATFYAAEIMCGLQFLHS--K--------G---IIYRDLKLDNVLLD-R-----DG-HI---------KIADFGMCKEN-----------------IFGESRA--------------ST---FCGTPDYIAPEI--LQ------GLK-YTFSVDWWSFGVLLYEMLI-GQ--------------SP---------------FHGD--------DEDELF----ES----IRV---DTPHYPRWIT-----------------------------------------KESKD-ILEKLFEREPTKRLG------VTG-NIKIHPFF--------------
----F-NFIKVLGKGSFGKV---MLAEL---K----------------GKDE---VYAV-KVL---KKD--V-ILQDD---D-V-DCTM---TEKRILALA-RK---HPYLTQLYCCFQ--T----------KDR--LFFVMEYVNGGDLMFQIQ--------RSR-----------------------------------------------------------------------------------------------------KF---DEPRSRFYAAEVTSALMFLHQ--H--------G---VIYRDLKLDNILLD-A-----EG-HC---------KLADFGMCKEG-----------------ILNGVTT--------------TT---FCGTPDYIAPEI--LQ------ELE-YGPSVDWWALGVLMYEMMA-GQ--------------PP---------------FEAD--------NEDDLF----ES----ILH---DDVLYPVWLS-----------------------------------------KEAVS-ILKAFMTKNPHKRLGCVASQNGED-AIKQHP--FF------------
-----FEFIRVLGKGSFGKV---MLARV---K----------------ETGD---LYAV-KVL---KKD--V-ILQDD---D-V-ECTM---TEKRILSLA-RN---HPFLTQLFCCFQ--T----------PDR--LFFVMEFVNGGDLMFHIQ--------KSR-----------------------------------------------------------------------------------------------------RF---DEARARFYAAEIISALMFLHD--K--------G---IIYRDLKLDNVLLD-H-----EG-HC---------KLADFGMCKEG-----------------ICNGVTT--------------AT---FCGTPDYIAPEI--LQ------EML-YGPAVDWWAMGVLLYEMLC-GH--------------AP---------------FEAE--------NEDDLF----EA----ILN---DEVVYPTWLH-----------------------------------------EDATG-ILKSFMTKNPTMRLGSLT-QGGEH-AILRHPF-F-------------
---FI--LHKMLGKGSFGKV---FLAEF---K----------------KTNQ---FFAI-KAL---KKD--V-VLMDD---D-V-ECTM---VEKRVLSLA-WE---HPFLTHMFCTFQ--T----------KEN--LFFVMEYLNGGDLMYHIQ--------SCH-----------------------------------------------------------------------------------------------------KF---DLSRATFYAAEIILGLQFLHS--K--------G---IVYRDLKLDNILLD-K-----DG-HI---------KIADFGMCKEN-----------------MLGDAKT--------------NT---FCGTPDYIAPEI--LL------GQK-YNHSVDWWSFGVLLYEMLI-GQ--------------SP---------------FHGQ--------DEEELF----HS----IRM---DNPFYPRWLE-----------------------------------------KEAKD-LLVKLFVREPEKRLG-------VRGDIRQHPLF--------------
---PD----EVLGSGQFGIV---YGGKH---R----------------KTGR---DVAI-KII---DKL--R-FPTKQ---E-S-QLRN----EVAILQNL--H---HPGVVNLECMFE--T----------PER--VFVVMEKLHGDMLEMILS-------SEKG-----------------------------------------------------------------------------------------------------RL---PEHITKFLITQILVALRHLHF--K--------N---IVHCDLKPENVLLA-S-----AD-PFP------QVKLCDFGFARI------------------IGEKSFR--------------RS---VVGTPAYLAPEV--LR------NKG-YNRSLDMWSVGVIIYVSLS-GT--------------FP---------------FNED----------EDIH----DQ----IQN---AAFMYPPNPWKEIS-------------------------------------HEAID-LINNLLQVKMRKRYS-------VD-KTLSHPWL--------------
---PD----EVLGSGQFGVV---YGGKH---R----------------KTGR---DVAV-KVI---DKL--R-FPTKQ---E-S-QLRN----EVAILQSL--R---HPGIVNLECMFE--T----------PEK--VFVVMEKLHGDMLEMILS-------SEKG-----------------------------------------------------------------------------------------------------RL---PERLTKFLITQILVALRHLHF--K--------N---IVHCDLKPENVLLA-S-----AD-PFP------QVKLCDFGFARI------------------IGEKSFR--------------RS---VVGTPAYLAPEV--LL------NQG-YNRSLDMWSVGVIMYVSLS-GT--------------FP---------------FNED----------EDIN----DQ----IQN---AAFMYPASPWSHIS-------------------------------------AGAID-LINNLLQVKMRKRYS-------VD-KSLSHPWL--------------
--FAD----EVLGSGQFGIV---YGGKH---R----------------KTGR---DVAI-KVI---DKM--R-FPTKQ---E-S-QLRN----EVAILQNL--H---HPGIVNLECMFE--T----------PER--VFVVMEKLHGDMLEMILS-------SEKS-----------------------------------------------------------------------------------------------------RL---PERITKFMVTQILVALRNLHF--K--------N---IVHCDLKPENVLLA-S-----AE-PFP------QVKLCDFGFARI------------------IGEKSFR--------------RS---VVGTPAYLAPEV--LR------SKG-YNRSLDMWSVGVIIYVSLS-GT--------------FP---------------FNED----------EDIN----DQ----IQN---AAFMYPPNPWREIS-------------------------------------GEAID-LINNLLQVKMRKRYS-------VD-KSLSHPWL--------------
----F-NIIDTLGVGGFGRV---ELVQL---KS---------------EESK---TFAM-KIL---KKR--H-IVDTR---Q-Q-EHIR---SEKQIMQGA--H---SDFIVRLYRTFK--D----------SKY--LYMLMEACLGGELWTILR--------DRG-----------------------------------------------------------------------------------------------------SF---EDSTTRFYTACVVEAFAYLHS--K--------G---IIYRDLKPENLILD-H-----RG-YA---------KLVDFGFAKK------------------IGFGKKT--------------WT---FCGTPEYVAPEI--IL------NKG-HDISADYWSLGILMYELLT-GS--------------PP---------------FSGP--------DPMKTY----NI----ILR---GIDMIEFPKKIA---------------------------------------KNAAN-LIKKLCRDNPSERLGNL--KNGVK-DIQKHKWF--------------
----L-EIIATLGVGGFGRV---ELVKV---K----------------NENV---AFAM-KCI---RKK--H-IVDTK---Q-Q-EHVY---SEKRILEEL--C---SPFIVKLYRTFK--D----------NKY--VYMLLEACLGGELWSILR--------DRG-----------------------------------------------------------------------------------------------------SF---DEPTSKFCVACVTEAFDYLHR--L--------G---IIYRDLKPENLILD-A-----EG-YL---------KLVDFGFAKK------------------IGSGQKT--------------WT---FCGTPEYVAPEV--IL------NKG-HDFSVDFWSLGILVYELLT-GN--------------PP---------------FSGV--------DQMMTY----NL----ILK---GIEKMDFPRKIT---------------------------------------RRPED-LIRRLCRQNPTERLGNL--KNGIN-DIKKHRWL--------------
---FD--TLATVGTGTFGRV---HLVKE---K----------------TAKH---FFAL-KVM---SIP--D-VIRLK---Q-E-QHVH---NEKSVLKEV--S---HPFLIRLFWTWH--D----------ERF--LYMLMEYVPGGELFSYLR--------NRG-----------------------------------------------------------------------------------------------------RF---SSTTGLFYSAEIICAIEYLHS--K--------E---IVYRDLKPENILLD-R-----DG-HI---------KLTDFGFAKK--------------------LVDRT--------------WT---LCGTPEYLAPEV--IQ------SKG-HGRAVDWWALGILIFEMLS-GF--------------PP---------------FFDD--------NPFGIY----QK----ILA---GKIDFPRHLD-----------------------------------------FHVKD-LIKKLLVVDRTRRLGNM--KNGAN-DVKHHRWF--------------
----V-VLNRILGEGFFGEV---YEGVY---T-------------NHKGEKI---NVAV-KTC---K-K--D-CT-LDN-KE-K-FM-S----EAVIMKNL--D---HPHIVKLIGIIE-------------EEP--TWIIMELYPYGELGHYLE---------RN--------------------------------------------------------------------------------------------------K-NSL---KVLTLVLYSLQICKAMAYLES--I--------N---CVHRDIAVRNILVA-S-----PE-CV---------KLGDFGLSRYI-----------------E--DEDY--------------YKASVTRLPIKWMSPES--IN------FRR-FTTASDVWMFAVCMWEILSFGK--------------QP---------------FFWL-----ENKDVIGVL----EK----GDR---LPKPDLCP-------------------------------------------PVLYT-LMTRCWDYDPSDRPR-------FT-ELVCS--L--------------
----F-TLCRKLGSGYFGEV---FEGLW---K-----------------DRV---QVAI-KVI---S-R--D-NL-LH--QQ-M-LQ-S----EIQAMKKL--R---HKHILALYAVVS--V----------GDP--VYIITELMAKGSLLELLR---------DS-------------------------------------------------------------------------------------------------DE-KVL---PVSELLDIAWQVAEGMCYLES--Q--------N---YIHRDLAARNILVG-E-----NT-LC---------KVGDFGLARLI--------------------KEDV--------------YLSHDHNIPYKWTAPEA--LS------RGH-YSTKSDVWSFGILLHEMFSRGQ--------------VP---------------YPGM-----SNHEAFLRV----DA----GYR---MPCPLECP-------------------------------------------PSVHK-LMLTCWCRDPEQRPC-------FK-ALRERL----------------
----L-VLGKTLGEGEFGKV---VKATA---FH-----------LKGRAGYT---TVAV-KML---K-E--N-AS-PSE-LR-D-LL-S----EFNVLKQV--N---HPHVIKLYGACS--Q----------DGP--LLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDE-RAL---TMGDLISFAWQISQGMQYLAE--M--------K---LVHRDLAARNILVA-E-----GR-KM---------KISDFGLSRDV-------------Y---E--EDSY--------------VKRSQGRIPVKWMAIES--LF------DHI-YTTQSDVWSFGVLLWEIVTLGG--------------NP---------------YPGI-----PPERLFNLL----KT----GHR---MERPDNCS-------------------------------------------EEMYR-LMLQCWKQEPDKRPV-------FA-DISKDL----------------
--LAD---LRYLSRGASGTV---SSARH---A----------------DWRV---QVAV-KHL---HIH--T-PLLDS---E-R-KDVL---REAEILHKA--R---FSYILPILGICN--E----------PEF--LGIVTEYMPNGSLNELLH--------RKT-----------------------------------------------------------------------------------------------------EYPDVAWPLRFRILHEIALGVNYLHN--MT------PP---LLHHDLKTQNILLD-N-----EF-HV---------KIADFGLSKWRMM------------SLSQSRSSKS--------------AP---EGGTIIYMPPEN--YEP---GQKSR-ASIKHDIYSYAVITWEVLS-RK--------------QP---------------FEDVT---NPLQIMYSVS----QG----HRP---VINEESLPYDIPHR-------------------------------------ARMIS-LIESGWAQNPDERPS-------FL-KCL-----IEL-----------
-FTGW----EKVGSGGFGQV---YKVRH---V----------------HWKT---WLAI-KCS---PSL--H-VDDRE---R-M-ELLE----EAKKMEMA--K---FRYILPVYGIC--------------REP--VGLVMEYMETGSLEKLLA---------SE-----------------------------------------------------------------------------------------------------PL---PWDLRFRIIHETAVGMNFLHC--MA------PP---LLHLDLKPANILLD-A-----HY-HV---------KISDFGLAKCNG--------------LSHSHDLSM--------------DG---LFGTIAYLPPER--IR----EKSRL-FDTKHDVYSFAIVIWGVLT-QK--------------KP---------------FADE----KNILHIMVKV----VK----GHR---PELPPVCRARPRAC-------------------------------------SHLIR-LMQRCWQGDPRVRPT-------FQ---------GNGLN---------
---LT--LRLLLGSGAFGEV---YEGTA---VDI----------LGVGSGEI---KVAV-KTL---K-K--G-ST-DQE-KI-E-FL-K----EAHLMSKF--N---HPNILKQLGVCL--L----------NEP--QYIILELMEGGDLLTYLR---------KARM--------------------------------------------------------------------------------------------ATFYG-PLL---TLVDLVDLCVDISKGCVYLER--M--------H---FIHRDLAARNCLVS-VKDYTSPR-IV---------KIGDFGLARDI-------------Y---K--NDYY--------------RKRGEGLLPVRWMAPES--LM------DGI-FTTQSDVWSFGILIWEILTLGH--------------QP---------------YPAH-----SNLDVLNYV----QT----GGR---LEPPRNCP-------------------------------------------DDLWN-LMTQCWAQEPDQRPT-------FH-RIQDQL----------------
-----FELLKVLGQGSFGKVFLVRKVTR---P----------------DSGH---LYAM-KVL---KKA--T-LKVRD---R-V-RTKM----ERDILADV--N---HPFVVKLHYAFQ--T----------EGK--LYLILDFLRGGDLFTRLS--------KEV-----------------------------------------------------------------------------------------------------MF---TEEDVKFYLAELALGLDHLHS--L--------G---IIYRDLKPENILLD-E-----EG-HI---------KLTDFGLSKEA-----------------IDHEKKA--------------YS---FCGTVEYMAPEV--VN------RQG-HSHSADWWSYGVLMFEMLT-GS--------------LP---------------FQGK--------DRKETM----TL----ILK---AKLGMPQFLS-----------------------------------------TEAQS-LLRALFKRNPANRLGSG--PDGAE-EIKRHV--FY------------
-----FELLKVLGQGSYGKV---FLVRK---V----------------KGSDAGQLYAM-KVL---KKA--T-LKVRD---R-V-RSKM----ERDILAEV--N---HPFIVKLHYAFQ--T----------EGK--LYLILDFLRGGDLFTRLS--------KEV-----------------------------------------------------------------------------------------------------MF---TEEDVKFYLAELALALDHLHS--L--------G---IIYRDLKPENILLD-E-----EG-HI---------KITDFGLSKEA-----------------IDHDKRA--------------YS---FCGTIEYMAPEV--VN------RRG-HTQSADWWSFGVLMFEMLT-GS--------------LP---------------FQGK--------DRKETM----AL----ILK---AKLGMPQFLS-----------------------------------------GEAQS-LLRALFKRNPCNRLGAG--IDGVE-EIKRHPFF--------------
-----FELLKVLGQGSFGKV---FLVKK---I----------------SGSDARQLYAM-KVL---KKA--T-LKVRD---R-V-RTKM----ERDILVEV--N---HPFIVKLHYAFQ--T----------EGK--LYLILDFLRGGDLFTRLS--------KEV-----------------------------------------------------------------------------------------------------MF---TEEDVKFYLAELALALDHLHS--L--------G---IIYRDLKPENILLD-E-----EG-HI---------KLTDFGLSKES-----------------IDHEKKA--------------YS---FCGTVEYMAPEV--VN------RRG-HTQSADWWSFGVLMFEMLT-GT--------------LP---------------FQGK--------DRKETM----TM----ILK---AKLGMPQFLS-----------------------------------------PEAQS-LLRMLFKRNPANRLGAG--PDGVE-EIKRHSFF--------------
-----FELLKVLGQGSFGKV---FLVRK---K----------------TGPDAGQLYAM-KVL---KKA--S-LKVRD---R-V-RTKM----ERDILVEV--N---HPFIVKLHYAFQ--T----------EGK--LYLILDFLRGGDVFTRLS--------KEV-----------------------------------------------------------------------------------------------------LF---TEEDVKFYLAELALALDHLHQ--L--------G---IVYRDLKPENILLD-E-----IG-HI---------KLTDFGLSKES-----------------VDQEKKA--------------YS---FCGTVEYMAPEV--VN------RRG-HSQSADWWSYGVLMFEMLT-GT--------------LP---------------FQGK--------DRNETM----NM----ILK---AKLGMPQFLS-----------------------------------------AEAQS-LLRMLFKRNPANRLGS----EGVE-EIKRHLFF--------------
-----FELLRVLGKGGYGKV---FQVRKVTGA----------------NTGK---IFAM-KVL---KKA--M-IVRNA---K-D-TAHTK--AERNILEEV--K---HPFIVDLIYAFQ--T----------GGK--LYLILEYLSGGELFMQLE--------REG-----------------------------------------------------------------------------------------------------IF---MEDTACFYLAEISMALGHLHQ--K--------G---IIYRDLKPENIMLN-H-----QG-HV---------KLTDFGLCKES-----------------IHDGTVT--------------HT---FCGTIEYMAPEI--LM------RSG-HNRAVDWWSLGALMYDMLT-GA--------------PP---------------FTGE--------NRKKTI----DK----ILK---CKLNLPPYLT-----------------------------------------QEARD-LLKKLLKRNAASRLGAG--PGDAG-EVQAHPFF--------------
-----YDIERTLGKGNFAVV---KLARH---R----------------VTKT---QVAI-KII---DKT--R-LDSSN---L-E-KIYR----EVQLMKLL--N---HPHIIKLYQVME--T----------KDM--LYIVTEFAKNGEMFDYLT--------SNG-----------------------------------------------------------------------------------------------------HL---SENEARKKFWQILSAVEYCHD--H--------H---IVHRDLKTENLLLD-G-----NM-DI---------KLADFGFGNF------------------YKSGEPL--------------ST---WCGSPPYAAPEV--FE-----GKEY-EGPQLDIWSLGVVLYVLVC-GS--------------LP---------------FDGP--------NLPTLR----QR----VLE---GRFRIPFFMS-----------------------------------------QDCES-LIRRMLVVDPARRIT-------IA-QIRQHRWM--------------
-----YDIEGTLGKGNFAVV---KLGRH---R----------------ITKT---EVAI-KII---DKS--Q-LDAVN---L-E-KIYR----EVQIMKML--D---HPHIIKLYQVME--T----------KSM--LYLVTEYAKNGEIFDYLA--------NHG-----------------------------------------------------------------------------------------------------RL---NESEARRKFWQILSAVDYCHG--R--------K---IVHRDLKAENLLLD-N-----NM-NI---------KIADFGFGNF------------------FKSGELL--------------AT---WCGSPPYAAPEV--FE-----GQQY-EGPQLDIWSMGVVLYVLVC-GA--------------LP---------------FDGP--------TLPILR----QR----VLE---GRFRIPYFMS-----------------------------------------EDCEH-LIRRMLVLDPSKRLT-------IA-QIKEHKWM--------------
-----WEIIGELGDGAFGKV---YKAQN---K----------------ETSV---LAAA-KVI---DTK--S-EEELE---D-Y-M--V----EIDILASC--D---HPNIVKLLDAFY--Y----------ENN--LWILIEFCAGGAVDAVML-------ELER-----------------------------------------------------------------------------------------------------PL---TESQIQVVCKQTLDALNYLHD--N--------K---IIHRDLKAGNILFT-L-----DG-DI---------KLADFGVSAKN-----------------TRTIQRR--------------DS---FIGTPYWMAPEV--VMCE-TSKDRP-YDYKADVWSLGITLIEMAE-IE--------------PP---------------HHEL-----NPMRVLLKI----AK----SEP---PTLAQPSRWS-----------------------------------------SNFKD-FLKKCLEKNVDARWT-------TS-QLLQHPFV--------------
-----YDLDKTLGRGHFAVV---KLARH---V----------------FTGE---KVAV-KVI---DKT--K-LDTLA---T-G-HLFQ----EVRCMKLV--Q---HPNIVRLYEVID--T----------QTK--LYLILELGDGGDMFDYIM-------KHEE-----------------------------------------------------------------------------------------------------GL---NEDLAKKYFAQIVHAISYCHK--L--------H---VVHRDLKPENVVFFEK-----QG-LV---------KLTDFGFSNK------------------FQPGKKL--------------TT---SCGSLAYSAPEI--LL-----GDEY-DAPAVDIWSLGVILFMLVC-GQ--------------PP---------------FQEA--------NDSETL----TM----IMD---CKYTVPSHVS-----------------------------------------KECKD-LITRMLQRDPKRRAS-------LE-EIENHPWL--------------
----L-RLEVKLGQGCFGEV---WMGTW---N-----------------GTT---RVAI-KTL---K-P--G-TM-SP---E-A-FL-Q----EAQVMKKL--R---HEKLVQLYAVVS-------------EEP--IYIVTEYMSKGSLLDFLK---------GE-------------------------------------------------------------------------------------------------TG-KYL---RLPQLVDMAAQIASGMAYVER--M--------N---YVHRDLRAANILVG-E-----NL-VC---------KVADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEA--AL------YGR-FTIKSDVWSFGILLTELTTKGR--------------VP---------------YPGM-----VNREVLDQV----ER----GYR---MPCPPECP-------------------------------------------ESLHD-LMCQCWRKEPEERPT-------FE-YLQAF--L--------------
---FA--LGRKLGEGYFGEV---WEGLW---L-----------------GSL---PVAI-KVI---K-S--A-NM-K---LT-D-LA-K----EIQTLKGL--R---HERLIRLHAVCS--G----------GEP--VYIVTELMRKGNLQAFLG---------TP-------------------------------------------------------------------------------------------------EG-RAL---RLPPLLGFACQVAEGMSYLEE--Q--------R---VVHRDLAARNVLVD-D-----GL-AC---------KVADFGLARLL-----------------K--DDIY--------------SPSSSSKIPVKWTAPEA--AN------YRV-FSQKSDVWSFGVLLHEVFTYGQ--------------CP---------------YEGM-----TNHETLQQI----MR----GYR---LPRPAACP-------------------------------------------AEVYV-LMLECWRSSPEERPS-------FA-TLREKL----------------
-----WEIVGELGDGAFGKV---YKAKN---K----------------ETGA---LAAA-KVI---ETK--S-EEELE---D-Y-I--V----EIEILATC--D---HPYIVKLLGAYY--H----------DGK--LWIMIEFCPGGAVDAIML-------ELDR-----------------------------------------------------------------------------------------------------GL---TEPQIQVVCRQMLEALNFLHS--K--------R---IIHRDLKAGNVLMT-L-----EG-DI---------RLADFGVSAKN-----------------LKTLQKR--------------DS---FIGTPYWMAPEV--VMCE-TMKDTP-YDYKADIWSLGITLIEMAQ-IE--------------PP---------------HHEL-----NPMRVLLKI----AK----SDP---PTLLTPSKWS-----------------------------------------VEFRD-FLKIALDKNPETRPS-------AA-QLLEHPFV--------------
-----FTKLEKIGKGSFGEV---FKGID---N----------------RTQK---VVAI-KII---DLE--E-AEDEI---E-D-IQ-Q----EITVLSQC--D---SPYVTKYYGSYL--K----------DTK--LWIIMEYLGGGSALDLLE---------PG-----------------------------------------------------------------------------------------------------PL---DETQIATILREILKGLDYLHS--E--------K---KIHRDIKAANVLLS-E-----HG-EV---------KLADFGVAGQL-----------------TDTQIKR--------------NT---FVGTPFWMAPEV--IK------QSA-YDSKADIWSLGITAIELAR-GE--------------PP---------------HSEL-----HPMKVLFLI----PK----NNP---PTLEGNYS-------------------------------------------KPLKE-FVEACLNKEPSFRPT-------AK-ELLKHKFI--------------
-----YHVLEMIGEGSFGRV---YKGRR---K----------------YSAQ---VVAL-KFI---PKL--G-RSEKE---L-R-NLQR----EIEIMRGL--R---HPNIVHMLDSFE--T----------DKE--VVVVTDYAEG-ELFQILE--------DDG-----------------------------------------------------------------------------------------------------KL---PEDQVQAIAAQLVSALYYLHS--H--------R---ILHRDMKPQNILLA-K-----GG-GI---------KLCDFGFARAM-----------------STNTMVL--------------TS---IKGTPLYMSPEL--VE------ERP-YDHTADLWSVGCILYELAV-GT--------------PP---------------FYAT--------SIFQLV----SL----ILK---DPVRWPSTIS-----------------------------------------PCFKN-FLQGLLTKDPRQRLS-------WP-DLLYHPFI--------------
-----YELQEVIGSGATAVV---QAALC---K----------------PRQE---RVAI-KRI---NLE--K-CQTSM---D-E--LLK----EIQAMSQC--S---HPNVVTYYTSFV--V----------KDE--LWLVMKLLSGGSMLDIIKYIVNRGEHKNG-----------------------------------------------------------------------------------------------------VL---EEAIIATILKEVLEGLDYLHR--N--------G---QIHRDLKAGNILLG-E-----DG-SV---------QIADFGVSAFLAT------------GGDVTRNKVR--------------KT---FVGTPCWMAPEV--ME-----QVRG-YDFKADMWSFGITAIELAT-GA--------------AP---------------YHKY-----PPMKVLMLT----LQ----NDP---PTLETGVEDKE--MMK--------------------------------KYGKSFRK-LLSLCLQKDPSKRPT-------AA-ELLKCKFF--------------
--TLE---DKELGSGNFGTV---KKGYY---Q--------------MKKVVK---TVAV-KIL---K-N--E-AN-DPALKD-E-LL-A----EANVMQQL--D---NPYIVRMIGICE-------------AES--WMLVMEMAELGPLNKYLQ---------QN----------------------------------------------------------------------------------------------------RHV---KDKNIIELVHQVSMGMKYLEE--S--------N---FVHRDLAARNVLLV-T-----QH-YA---------KISDFGLSKAL-------------R---A--DENY-------------YKAQTHGKWPVKWYAPEC--IN------YYK-FSSKSDVWSFGVLMWEAFSYGQ--------------KP---------------YRGM-----KGSEVTAML----EK----GER---MGCPAGCP-------------------------------------------REMYD-LMNLCWTYDVENRPG-------FA-AVE----LRL------------
-----LTFMRELGSGLFGVV---RLGKW---R-----------------AQY---KVAI-KAI---R-E--G-AM-CE---E-D-FI-E----EAKVMMKL--T---HPKLVQLYGVCT--Q----------QKP--IYIVTEFMERGCLLNFLR---------QR--------------------------------------------------------------------------------------------------Q-GHF---SRDVLLSMCQDVCEGMEYLER--N--------S---FIHRDLAARNCLVS-E-----AG-VV---------KVSDFGMARYV-----------------L--DDQY--------------TSSSGAKFPVKWCPPEV--FN------YSR-FSSKSDVWSFGVLMWEVFTEGR--------------MP---------------FEKY-----TNYEVVTMV----TR----GHR---LYQPKLAS-------------------------------------------NYVYE-VMLRCWQEKPEGRPS-------FE-DLLRT--I--------------
-----IKFQDVIGEGNFGQV---LKARI---K--------------KDGLRM---DAAI-KRM---K-E--Y-AS-KDD-HR-D-FA-G----ELEVLCKLG-H---HPNIINLLGACE--H----------RGY--LYLAIEYAPHGNLLDFLR---------KSRVLETDP-----------------------------------------------------------------------------------AFAIANSTA-STL---SSQQLLHFAADVARGMDYLSQ--K--------Q---FIHRDLAARNILVG-E-----NY-VA---------KIADFGLSRGQ---------------------EVY--------------VKKTMGRLPVRWMAIES--LN------YSV-YTTNSDVWSYGVLLWEIVSLGG--------------TP---------------YCGM-----TCAELYEKL----PQ----GYR---LEKPLNCD-------------------------------------------DEVYD-LMRQCWREKPYERPS-------FA-QILV---SL-------------
---IV--LQESIGKGRFGEV---WRGKW---R----------------GEE-----VAV-KIF---SSR--E-ERSWF---R-E-A-------EIYQTVML--R---HENILGFIAADN--KDN------GTWTQ--LWLVSDYHEHGSLFDYLN---------RY-----------------------------------------------------------------------------------------------------TV---TVEGMIKLALSTASGLAHLHM--EIVGTQGKPA---IAHRDLKSKNILVK-K-----NG-TC---------CIADLGLAVRHDS-------------ATDTIDIAP--------------NH---RVGTKRYMAPEV--LDDSINMKHFE-SFKRADIYAMGLVFWEIAR-RCSIGGI----HEDYQLP---------------YYDLVPSDPSVEEMRKVV----CE----QKL---RPNIPNRWQSCEAL-------------------------------------RVMAK-IMRECWYANGAARLT-------AL-RIKK----TL------------
-----ITFEDLIGEGNFGQV---IRAMI---K--------------KDGLKM---NAAI-KML---K-E--Y-AS-END-HR-D-FA-G----ELEVLCKLG-H---HPNIINLLGACK--N----------RGY--LYIAIEYAPYGNLLDFLR---------KSRVLETDP-----------------------------------------------------------------------------------AFAREHGTA-STL---SSRQLLRFASDAANGMQYLSE--K--------Q---FIHRDLAARNVLVG-E-----NL-AS---------KIADFGLSRGE---------------------EVY--------------VKKTMGRLPVRWMAIES--LN------YSV-YTTKSDVWSFGVLLWEIVSLGG--------------TP---------------YCGM-----TCAELYEKL----PQ----GYR---MEQPRNCD-------------------------------------------DEVYE-LMRQCWRDRPYERPP-------FA-QIALQ--L--------------
-----FELVELVGNGTYGQV---YKGRH---V----------------KTGQ---LAAI-KVM---DVT--G-DEEEE---I-K-Q-------EINMLKKY-SH---HRNIATYYGAFI--KKNP----PGMDDQ--LWLVMEFCGAGSVTDLIKN------TKGN-----------------------------------------------------------------------------------------------------TL---KEEWIAYICREILRGLSHLHQ--H--------K---VIHRDIKGQNVLLT-E-----NA-EV---------KLVDFGVSAQL-----------------DRTVGRR--------------NT---FIGTPYWMAPEV--IACD-ENPDAT-YDFKSDLWSLGITAIEMAE-GA--------------PP---------------LCDM-----HPMRALFLI----PR----NPA---PRLKSKKWS------------------------------------------KKFQS-FIESCLVKNHSQRPA-------TE-QLMKHPFI--------------
--VCR---GELLGSGCFGVV---HRGLW---T-------------LPSGKSV---PVAV-KSLRVGP-E--G-PM-GTE-LG-D-FL-R----EVSVMMNL--E---HPHVLRLHGLVL-------------GQP--LQMVMELAPLGSLHARLT---------AP------------------------------------------------------------------------------------------------APT-PPL---LVALLCLFLRQLAGAMAYLGA--R--------G---LVHRDLATRNLLLA-S-----PR-TI---------KVADFGLVRPL------------GG---A--RGRY--------------VMGGPRPIPYAWCAPES--LR------HGA-FSSASDVWMFGVTLWEMFSGGE--------------EP---------------WAGV-----PPYLILQRL----ED----RAR---LPRPPLCS-------------------------------------------RALYS-LALRCWAPHPADRPS-------FS-HLE----GLL------------
----L-RLLEKLGDGSFGVV---RRGEW---D-------------APSGKTV---SVAV-KCL---K-PDVL-SQ-PEA-MD-D-FI-R----EVNAMHSL--D---HRNLIRLYGVVL-------------TPP--MKMVTELAPLGSLLDRLR---------KH--------------------------------------------------------------------------------------------------Q-GHF---LLGTLSRYAVQVAEGMGYLES--K--------R---FIHRDLAARNLLLA-T-----RD-LV---------KIGDFGLMRAL------------PQ---N--DDHY--------------VMQEHRKVPFAWCAPES--LK------TRT-FSHASDTWMFGVTLWEMFTYGQ--------------EP---------------WIGL-----NGSQILHKI---DKE----GER---LPRPEDCP-------------------------------------------QDIYN-VMVQCWAHKPEDRPT-------FV-ALRDF--L--------------
-----IEFHEIIGSGSFGKV---YKGRC---R------------------NK---IVAI-KRY---R-ANTY-CS-KSD-VD-M-FC-R----EVSILCQL--N---HPCVIQFVGACL-ND----------PSQ--FAIVTQYISGGSLFSLLH---------EQ--------------------------------------------------------------------------------------------------K-RIL---DLQSKLIIAVDVAKGMEYLHNLTQ--------P---IIHRDLNSHNILLY-E-----DG-HA---------VVADFGESRFL-------------Q---S--LD-E--------------DNMTKQPGNLRWMAPEV--FT------QCTRYTIKADVFSYALCLWEILT-GE--------------IP---------------FAHL-----KPAAAAADM---AYH----HIR---PPIGYSIP-------------------------------------------KPISS-LLIRGWNACPEGRPE-------FS-EVVMKL----------------
YIVGI-----NLGKGSYAKV---KSAYS---E----------------RLKF---NVAV-KII---DRK--K-TPTDF---V-E-RF-LP--REMDILATV--N---HGSIIKTYEIFE--T---------SDGR--IYIIMELGVQGDLLEFIK--------CQG-----------------------------------------------------------------------------------------------------AL---HEDVARKMFRQLSSAVKYCHD--L--------D---IVHRDLKCENLLLD-K-----DF-NI---------KLSDFGFSKRCLR-------------DSNGRIILS--------------KT---FCGSAAYAAPEV--LQ-----SIPY-QPKVYDIWSLGVILYIMVC-GS--------------MP---------------YDDS--------DIRKML----RI----QKE---HRVDFPRSKNLT---------------------------------------CECKD-LIYRMLQPDVSQRLH-------ID-EILSHSWL--------------
----L-AFIKEIGSGQFGVV---HLGEW---R-----------------SHI---QVAI-KAI---N-E--G-SM-SE---E-D-FI-E----EAKVMMKL--S---HSKLVQLYGVCI--Q----------RKP--LYIVTEFMENGCLLNYLR---------EN--------------------------------------------------------------------------------------------------K-GKL---RKEMLLSVCQDICEGMEYLER--N--------G---YIHRDLAARNCLVS-S-----TC-IV---------KISDFGMTRYV-----------------L--DDEY--------------VSSFGAKFPIKWSPPEV--FL------FNK-YSSKSDVWSFGVLMWEVFTEGK--------------MP---------------FENK-----SNLQVVEAI----SE----GFR---LYRPHLAP-------------------------------------------MSIYE-VMYSCWHEKPEGRPT-------FA-ELLR---AV-------------
----L-KKIRDLGEGHFGKV---SLYCY---DP------------TNDGTGE---MVAV-KAL---K-A--D-CG-PQH-RS-G-WK-Q----EIDILRTL--Y---HEHIIKYKGCCEDQG----------EKS--LQLVMEYVPLGSLRDYLP---------RH-----------------------------------------------------------------------------------------------------SI---GLAQLLLFAQQICEGMAYLHA--Q--------H---YIHRDLAARNVLLD-N-----DR-LV---------KIGDFGLAKAV------------PE---G--HEYY--------------RVREDGDSPVFWYAPEC--LK------EYK-FYYASDVWSFGVTLYELLTHCD--------------SSQSPPTKF-LELIGIAQGQM-----TVLRLTELL----ER----GER---LPRPDKCP-------------------------------------------CEVYH-LMKNCWETEASFRPT-------FE-NLIP---IL-------------
---FS--RKDLIGHGAFAVV---FKGRH---R----------------EKHD--LEVAV-KCI---NKK--N-LAKSQ---T---LLGK----EIKILKEL--K---HENIVALYDFQE--M----------ANS--VYLVMEYCNGGDLADYLH--------AMR-----------------------------------------------------------------------------------------------------TL---SEDTIRLFLQQIAGAMRLLHS--K--------G---IIHRDLKPQNILLS-N-----PA-GRRANPNSIRVKIADFGFARY------------------LQSNMMA--------------AT---LCGSPMYMAPEV--IM------SQH-YDGKADLWSIGTIVYQCLT-GK--------------AP---------------FQAS-----SPQDLRLFY----EK----NKT---LVPTIPRETS-----------------------------------------APLRQ-LLLALLQRNHKDRMD-------FD-EFFHHPFL--------------
----Y-SKRDLVGHGAFAVV---FRGRH---R----------------QKTD--WEVAI-KSI---NKK--N-LSKSQ-----I-LLGK----EIKILKEL--Q---HENIVALYDVQE--L----------PNS--VFLVMEYCNGGDLADYLQ--------AKG-----------------------------------------------------------------------------------------------------TL---SEDTIRVFLHQIAAAMRILHS--K--------G---IIHRDLKPQNILLS-Y-----AN-RRKSSVSGIRIKIADFGFARY------------------LHSNMMA--------------AT---LCGSPMYMAPEV--IM------SQH-YDAKADLWSIGTVIYQCLV-GK--------------PP---------------FQAN-----SPQDLRMFY----EK----NRS-----LMPSIPRETS---------------------------------------PYLAN-LLLGLLQRNQKDRMD-------FE-AFFSHPFL--------------
----L-RLEVKLGQGCFGEV---WMGTW---N-----------------GTT---KVAI-KTL---K-P--G-TM-MP---E-A-FL-Q----EAQIMKKL--R---HDKLVPLYAVVS-------------EEP--IYIVTEFMSKGSLLDFLK---------EG-------------------------------------------------------------------------------------------------DG-KYL---KLPQLVDMAAQIADGMAYIER--M--------N---YIHRDLRAANILVG-E-----NL-VC---------KIADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEA--AL------YGR-FTIKSDVWSFGILQTELVTKGR--------------VP---------------YPGM-----VNREVLEQV----ER----GYR---MPCPQGCP-------------------------------------------ESLHE-LMNLCWKKDPDERPT-------FE-YIQSFL----------------
-LIAD----IELGCGNFGSV---RQGVY---R--------------MRKKQI---DVAI-KVL---K-Q--G-TE-KAD-TE-E-MM-R----EAQIMHQL--D---NPYIVRLIGVCQ-------------AEA--LMLVMEMAGGGPLHKFLV---------GK--------------------------------------------------------------------------------------------------R-EEI---PVSNVAELLHQVSMGMKYLEE--K--------N---FVHRDLAARNVLLV-N-----RH-YA---------KISDFGLSKAL------------GA---D--DSYY--------------TARSAGKWPLKWYAPEC--IN------FRK-FSSRSDVWSYGVTMWEALSYGQ--------------KP---------------YKKM-----KGPEVMAFI----EQ----GKR---MECPPECP-------------------------------------------PELYA-LMSDCWIYKWEDRPD-------FL-TVEQR--M--------------
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