|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FGR 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
Other AURKA 133
TK BLK 241
TK BMX 422
TK BTK 402
TK CSF1R 582
TK CSK 195
TK DDR1 572
TK DDR2 563
TK EGFR 712
TK EPHA1 624
TK EPHA3 621
TK EPHA4 621
TK EPHA5 675
TK EPHA6 631
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB4 615
TK EPHB6 670
TK ERBB4 718
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FYN 271
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK INSRR 979
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK LCK 245
TKL LIMK1 339
TKL LIMK2 331
TK LTK 510
TKL MAP3K7 36
TK MATK 235
TK MET 1078
TK MUSK 575
Other NEK11 29
Other NEK5 4
Other NEK7 34
Other NEK8 4
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
STE OXSR1 17
AGC PDPK1 82
TK PTK2 422
TK PTK6 191
TKL RAF1 349
TK RET 724
TKL RIPK4 22
TK ROS1 1945
STE SLK 34
TK SRC 270
TK SRMS 230
STE STK10 36
STE STK24 24
STE STK3 27
STE STK39 63
STE STK4 30
TK SYK 371
TK TEC 370
TK TEK 824
TK TIE1 839
TK TNK1 116
TK TNK2 150
TKL TNNI3K 463
TK TXK 271
Other ULK1 16
TK YES1 277
-------ITLERRLGTGCFGDVWLGTWN-----------------GST---KVAV-KTL---K-P--G-TM-SP---KA-FL-E-EAQVMKLL-RHDKLVQLYAVVS---EEP--IYIVTEFMCHGSLLDFLK---------NP-------------------------------------------------------------------EG-QDLRLPQLVDMAAQVAEGMAYMER--M--N---YIHRDLRAANILVG-E-----RL-AC---------KIADFGLARLI-----------------K--DDEY--------------NPCQGSKFPIKWTAPEAAL-----FGR---FTIKSDVWSFGILLTELITKGR-IP---------------YPGM---NKREVLEQV----EQ----GYH----MPCPPGCP-----------ASLYE-AMEQTWRLDPEERPTFEYLQSFL-------------
-------ITMKHKLGGGQYGEVYEGVWK----------------KYSL---TVAV-KTL---K-E--D-TM-EV---EE-FL-K-EAAVMKEI-KHPNLVQLLGVCT--REPP--FYIITEFMTYGNLLDYLR---------EC-------------------------------------------------------------------NR-QEVNAVVLLYMATQISSAMEYLEK--K--N---FIHRDLAARNCLVG-E-----NH-LV---------KVADFGLSRLM-----------------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNK---FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI---DLSQVYELL----EK----DYR----MERPEGCP-----------EKVYE-LMRACWQWNPSDRPSFAEIHQA--F-----------
-------ITMKHKLGGGQYGEVYVGVWK----------------KYSL---TVAV-KTL---K-E--D-TM-EV---EE-FL-K-EAAVMKEI-KHPNLVQLLGVCT--LEPP--FYIVTEYMPYGNLLDYLR---------EC-------------------------------------------------------------------NR-EEVTAVVLLYMATQISSAMEYLEK--K--N---FIHRDLAARNCLVG-E-----NH-VV---------KVADFGLSRLM-----------------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNT---FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI---DLSQVYDLL----EK----GYR----MEQPEGCP-----------PKVYE-LMRACWKWSPADRPSFAETHQA--F-----------
------I-TLIRGLGHGAFGEVYEGQVSG-----------MPNDPSPL---QVAV-KTL---P-E--V-CS-EQD-ELD-FL-M-EALIISKF-NHQNIVRCIGVSL--QSLP--RFILLELMAGGDLKSFLR---------ETRP--------------------------------------------------------------RPSQP-SSLAMLDLLHVARDIACGCQYLEE--N--H---FIHRDIAARNCLLT-CP--GPGR-VA---------KIGDFGMARDI-------------Y---R--ASYY--------------RKGGCAMLPVKWMPPEAFM-----EGI---FTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK---SNQEVLEFV----TS----GGR----MDPPKNCP-----------GPVYR-IMTQCWQHQPEDRPNFAIILER--I-----------
-------FEIGRPLGKGKFGNVYLAREK----------------QSKF---ILAL-KVL---FKA--QLEKAGV---EH-QLRR-EVEIQSHL-RHPNILRLYGYFH--DATR--VYLILEYAPLGTVYRELQ--------KLS-----------------------------------------------------------------------KFDEQRTATYITELANALSYCHS--K--R---VIHRDIKPENLLLG-S-----AG-EL---------KIADFGWSV-------------------HAPSSRR--------------TT---LCGTLDYLPPEMIE-----GRM---HDEKVDLWSLGVLCYEFLV-GK-PP---------------FEAN------TYQETY----KR----ISR----VEFTFPDFVT---------EGARD-LISRLLKHNPSQRPMLREVLEHPWI-----------
------L-RLVRKLGSGQFGEVWMGYYK-----------------NNM---KVAI-KTL---K-E--G-TM-SP---EA-FL-G-EANVMKAL-QHERLVRLYAVVT---KEP--IYIVTEYMARGCLLDFLK---------TD-------------------------------------------------------------------EG-SRLSLPRLIDMSAQIAEGMAYIER--M--N---SIHRDLRAANILVS-E-----AL-CC---------KIADFGLARII--------------------DSEY--------------TAQEGAKFPIKWTAPEAIH-----FGV---FTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM---SNPEVIRNL----ER----GYR----MPRPDTCP-----------PELYRGVIAECWRSRPEERPTFEFLQSV--L-----------
-------ITLLKELGSGQFGVVQLGKWK-----------------GQY---DVAV-KMI---K-E--G-SM-SE---DE-FF-Q-EAQTMMKL-SHPKLVKFYGVCS--KEYP--IYIVTEYISNGCLLNYLR---------SH--------------------------------------------------------------------G-KGLEPSQLLEMCYDVCEGMAFLES--H--Q---FIHRDLAARNCLVD-R-----DL-CV---------KVSDFGMTRYV-----------------L--DDQY--------------VSSVGTKFPVKWSAPEVFH-----YFK---YSSKSDVWAFGILMWEVFSLGK-QP---------------YDLY---DNSQVVLKV----SQ----GHR----LYRPHLAS-----------DTIYQ-IMYSCWHELPEKRPTFQQLLSS--I-----------
-------LTFLKELGTGQFGVVKYGKWR-----------------GQY---DVAI-KMI---K-E--G-SM-SE---DE-FI-E-EAKVMMNL-SHEKLVQLYGVCT--KQRP--IFIITEYMANGCLLNYLR---------EM--------------------------------------------------------------------R-HRFQTQQLLEMCKDVCEAMEYLES--K--Q---FLHRDLAARNCLVN-D-----QG-VV---------KVSDFGLSRYV-----------------L--DDEY--------------TSSVGSKFPVRWSPPEVLM-----YSK---FSSKSDIWAFGVLMWEIYSLGK-MP---------------YERF---TNSETAEHI----AQ----GLR----LYRPHLAS-----------EKVYT-IMYSCWHEKADERPTFKILLSN--I-----------
-------LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVL---KVAV-KML---K-S--T-AH-ADE-KEA-LM-S-ELKIMSHLGQHENIVNLLGACT--HGGP--VLVITEYCCYGDLLNFLR---------RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDG-RPLELRDLLHFSSQVAQGMAFLAS--K--N---CIHRDVAARNVLLT-N-----GH-VA---------KIGDFGLARDI-------------M---N--DSNY--------------IVKGNARLPVKWMAPESIF-----DCV---YTVQSDVWSYGILLWEIFSLGL-NP---------------YPGI-L-VNSKFYKLV----KD----GYQ----MAQPAFAP-----------KNIYS-IMQACWALEPTHRPTFQQICSFL-------------
-------LKLLQTIGKGEFGDVMLGDYR------------------GN---KVAV-KCI---K-N--D-AT-AQ----A-FL-A-EASVMTQL-RHSNLVQLLGVIV-EEKGG--LYIVTEYMAKGSLVDYLR---------SR-------------------------------------------------------------------GR-SVLGGDCLLKFSLDVCEAMEYLEG--N--N---FVHRDLAARNVLVS-E-----DN-VA---------KVSDFGLTKEA-----------------------S--------------STQDTGKLPVKWTAPEALR-----EKK---FSTKSDVWSFGILLWEIYSFGR-VP---------------YPRI---PLKDVVPRV----EK----GYK----MDAPDGCP-----------PAVYE-VMKNCWHLDAAMRPSFLQLREQL-------------
-------LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPL---LVAV-KIL---R-P--D-AT-KNA-RND-FL-K-EVKIMSRL-KDPNIIRLLGVCV--QDDP--LCMITDYMENGDLNQFLS---------AHQLEDKAAE--------------------------------------------------GAPGDGQAAQG-PTISYPMLLHVAAQIASGMRYLAT--L--N---FVHRDLATRNCLVG-E-----NF-TI---------KIADFGMSRNL-------------Y---A--GDYY--------------RVQGRAVLPIRWMAWECIL-----MGK---FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL---TDEQVIENAGEFFRD----QGRQ-VYLSRPPACP-----------QGLYE-LMLRCWSRESEQRPPFSQLHRFL-------------
-------LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPV---LVAV-KML---R-A--D-AN-KNA-RND-FL-K-EIKIMSRL-KDPNIIHLLAVCI--TDDP--LCMITEYMENGDLNQFLS---------RHEPPN-----------------------------------------------------------SSSSDV-RTVSYTNLKFMATQIASGMKYLSS--L--N---FVHRDLATRNCLVG-K-----NY-TI---------KIADFGMSRNL-------------Y---S--GDYY--------------RIQGRAVLPIRWMSWESIL-----LGK---FTTASDVWAFGVTLWETFTFCQEQP---------------YSQL---SDEQVIENT----GEFFRDQGRQ-TYLPQPAICP-----------DSVYK-LMLSCWRRDTKNRPSFQEIHL---LL----------
------F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKI---PVAI-KEL---R-E--A-TS-PKA-NKE-IL-D-EAYVMASV-DNPHVCRLLGICL---TST--VQLITQLMPFGCLLDYVR---------EH--------------------------------------------------------------------K-DNIGSQYLLNWCVQIAKGMNYLED--R--R---LVHRDLAARNVLVK-T-----PQ-HV---------KITDFGLAKLL-------------G---A--EEKE--------------YHAEGGKVPIKWMALESIL-----HRI---YTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI---PASEISSIL----EK----GER----LPQPPICT-----------IDVYM-IMVKCWMIDADSRPKFRELI----IEF---------
-----LM--VDTVIGEGEFGEVYRGTLR-------------LPSQDCK---TVAI-KTL---K-D--T-SP-GGQ-WWN-FL-R-EATIMGQF-SHPHILHLEGVVT--KRKP--IMIITEFMENGALDAFLR---------ER--------------------------------------------------------------------E-DQLVPGQLVAMLQGIASGMNYLSN--H--N---YVHRDLAARNILVN-Q-----NL-CC---------KVSDFGLTRLL-------------D---D--FDGT--------------YETQGGKIPIRWTAPEAIA-----HRI---FTTASDVWSFGIVMWEVLSFGD-KP---------------YGEM---SNQEVMKSI----ED----GYR----LPPPVDCP-----------APLYE-LMKNCWAYDRARRPHFQKLQAHL-------------
------I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEI---SVAI-KTL---K-V--G-YT-EKQ-RRD-FL-G-EASIMGQF-DHPNIIRLEGVVT--KSKP--VMIVTEYMENGSLDSFLR---------KH--------------------------------------------------------------------D-AQFTVIQLVGMLRGIASGMKYLSD--M--G---YVHRDLAARNILIN-S-----NL-VC---------KVSDFGLSRVL-------------E---D--DPEA-------------AYTTRGGKIPIRWTSPEAIA-----YRK---FTSASDVWSYGIVLWEVMSYGE-RP---------------YWEM---SNQDVIKAV----DE----GYR----LPPPMDCP-----------AALYQ-LMLDCWQKDRNNRPKFEQIVSIL-------------
-------IKIEKVIGVGEFGEVCSGRLK-------------VPGKREI---CVAI-KTL---K-A--G-YT-DKQ-RRD-FL-S-EASIMGQF-DHPNIIHLEGVVT--KCKP--VMIITEYMENGSLDAFLR---------KN--------------------------------------------------------------------D-GRFTVIQLVGMLRGIGSGMKYLSD--M--S---YVHRDLAARNILVN-S-----NL-VC---------KVSDFGMSRVL-------------E---D--DPEA-------------AYTTRGGKIPIRWTAPEAIA-----YRK---FTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM---SNQDVIKAI----EE----GYR----LPPPMDCP-----------IALHQ-LMLDCWQKERSDRPKFGQIVNML-------------
-------ITIERVIGAGEFGEVCSGRLK-------------LPGKREL---PVAI-KTL---K-V--G-YT-EKQ-RRD-FL-G-EASIMGQF-DHPNIIHLEGVVT--KSKP--VMIVTEYMENGSLDTFLK---------KN--------------------------------------------------------------------D-GQFTVIQLVGMLRGISAGMKYLSD--M--G---YVHRDLAARNILIN-S-----NL-VC---------KVSDFGLSRVL-------------E---D--DPEA-------------AYTTRGGKIPIRWTAPEAIA-----FRK---FTSASDVWSYGIVMWEVVSYGE-RP---------------YWEM---TNQDVIKAV----EE----GYR----LPSPMDCP-----------AALYQ-LMLDCWQKERNSRPKFDEIVNML-------------
LPPRIPA-------------------------------------------------------------------------------------------------------GRP--VMIVVEYMENGSLDSFLR---------KH--------------------------------------------------------------------D-GHFTVIQLVGMLRGIASGMKYLSD--M--G---YVHRDLAARNILVN-S-----NL-VC---------KVSDFGLSRVL-------------E---D--DPEA-------------AYTTTGGKIPIRWTAPEAIA-----YRK---FSSASDAWSYGIVMWEVMSYGE-RP---------------YWEM---SNQDVILSI----EE----GYR----LPAPMGCP-----------ASLHQ-LMLHCWQKERNHRPKFTDIVSFL-------------
-------IHIEKIIGSGDSGEVCYGRLR-------------VPGQRDV---PVAI-KAL---K-A--G-YT-ERQ-RRD-FL-S-EASIMGQF-DHPNIIRLEGVVT--RGRL--AMIVTEYMENGSLDTFLR---------TH--------------------------------------------------------------------D-GQFTIMQLVGMLRGVGAGMRYLSD--L--G---YVHRDLAARNVLVD-S-----NL-VC---------KVSDFGLSRVL-------------E---D--DPDA-------------AYTTTGGKIPIRWTAPEAIA-----FRT---FSSASDVWSFGVVMWEVLAYGE-RP---------------YWNM---TNRDVISSV----EE----GYR----LPAPMGCP-----------HALHQ-LMLDCWHKDRAQRPRFSQIVSVL-------------
------V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREI---YVAI-KTL---K-A--G-YS-EKQ-RRD-FL-S-EASIMGQF-DHPNIIRLEGVVT--KSRP--VMIITEFMENGALDSFLR---------QN--------------------------------------------------------------------D-GQFTVIQLVGMLRGIAAGMKYLAE--M--N---YVHRDLAARNILVN-S-----NL-VC---------KVSDFGLSRYLQ----------DDT---S--DPTY--------------TSSLGGKIPVRWTAPEAIA-----YRK---FTSASDVWSYGIVMWEVMSFGE-RP---------------YWDM---SNQDVINAI----EQ----DYR----LPPPMDCP-----------AALHQ-LMLDCWQKDRNSRPRFAEIVNTL-------------
------V-KIEQVIGAGEFGEVCSGHLK-------------LPGKREI---FVAI-KTL---K-S--G-YT-EKQ-RRD-FL-S-EASIMGQF-DHPNVIHLEGVVT--KSTP--VMIITEFMENGSLDSFLR---------QN--------------------------------------------------------------------D-GQFTVIQLVGMLRGIAAGMKYLAD--M--N---YVHRDLAARNILVN-S-----NL-VC---------KVSDFGLSRFLE----------DDT---S--DPTY--------------TSALGGKIPIRWTAPEAIQ-----YRK---FTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM---TNQDVINAI----EQ----DYR----LPPPMDCP-----------SALHQ-LMLDCWQKDRNHRPKFGQIVNTL-------------
------V-KIEEVIGAGEFGEVCRGRLK-------------APGKKES---CVAI-KTL---K-G--G-YT-ERQ-RRE-FL-S-EASIMGQF-EHPNIIRLEGVVT--NSMP--VMILTEFMENGALDSFLR---------LN--------------------------------------------------------------------D-GQFTVIQLVGMLRGIASGMRYLAE--M--S---YVHRDLAARNILVN-S-----NL-VC---------KVSDFGLSRFLE----------ENS---S--DPTY--------------TSSLGGKIPIRWTAPEAIA-----FRK---FTSASDAWSYGIVMWEVMSFGE-RP---------------YWDM---SNQDVINAI----EQ----DYR----LPPPPDCP-----------TSLHQ-LMLDCWQKDRNARPRFPQVVSAL-------------
-------IKIEEVIGTGSFGEVRQGRLQ-------------PRGRREQ---TVAI-QAL---W-A--G-GA-ESL-QMT-FL-G-RAAVLGQF-QHPNILRLEGVVT--KSRP--LMVLTEFMELGPLDSFLR---------QR--------------------------------------------------------------------E-GQFSSLQLVAMQRGVAAAMQYLSS--F--A---FVHRSLSAHSVLVN-S-----HL-VC---------KVARLGHSPQG-------------------------------------------PSCLLRWAAPEVIA-----HGK---HTTSSDVWSFGILMWEVMSYGE-RP---------------YWDM---SEQEVLNAI----EQ----EFR----LPPPPGCP-----------PGLHL-LMLDTWQKDRARRPHFDQLVA---AF----------
------L-KRVKVLGSGAFGTVYKGIWVP------------EGETVKI---PVAI-KIL---N-E--T-TG-PKA-NVE-FM-D-EALIMASM-DHPHLVRLLGVCL---SPT--IQLVTQLMPHGCLLEYVH---------EH--------------------------------------------------------------------K-DNIGSQLLLNWCVQIAKGMMYLEE--R--R---LVHRDLAARNVLVK-S-----PN-HV---------KITDFGLARLL-------------E---G--DEKE--------------YNADGGKMPIKWMALECIH-----YRK---FTHQSDVWSYGVTIWELMTFGG-KP---------------YDGI---PTREIPDLL----EK----GER----LPQPPICT-----------IDVYM-VMVKCWMIDADSRPKFKELAAE--F-----------
-----VI--LGELLGKGNFGEVYKGTLK-----------------DKT---SVAV-KTC---K-E--D-LP-QEL-KIK-FL-Q-EAKILKQY-DHPNIVKLIGVCT--QRQP--VYIIMELVSGGDFLTFLR---------RK--------------------------------------------------------------------K-DELKLKQLVKFSLDAAAGMLYLES--K--N---CIHRDLAARNCLVG-E-----NN-VL---------KISDFGMSRQE-----------------D--GGVY--------------SSSGLKQIPIKWTAPEALN-----YGR---YSSESDVWSFGILLWETFSLGV-CP---------------YPGM---TNQQAREQV----ER----GYR----MSAPQHCP-----------EDISK-IMMKCWDYKPENRPKFSELQKEL-------------
------L-VLGEQIGRGNFGEVFSGRLR----------------ADNT---LVAV-KSC---R-E--T-LP-PDL-KAK-FL-Q-EARILKQY-SHPNIVRLIGVCT--QKQP--IYIVMELVQGGDFLTFLR---------TE--------------------------------------------------------------------G-ARLRVKTLLQMVGDAAAGMEYLES--K--C---CIHRDLAARNCLVT-E-----KN-VL---------KISDFGMSREE-------------A---D--GVYA--------------ASGGLRQVPVKWTAPEALN-----YGR---YSSESDVWSFGILLWETFSLGA-SP---------------YPNL---SNQQTREFV----EK----GGR----LPCPELCP-----------DAVFR-LMEQCWAYEPGQRPSFSTIYQEL-------------
------L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVT---KVAV-KML---K-S--D-AT-EKD-LSD-LI-S-EMEMMKMIGKHKNIINLLGACT--QDGP--LYVIVEYASKGNLREYLQ---------ARRPPGLEY-----------------------------------------------------CYNPSHNPE-EQLSSKDLVSCAYQVARGMEYLAS--K--K---CIHRDLAARNVLVT-E-----DN-VM---------KIADFGLARDI-------------H---H--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRI---YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV---PVEELFKLL----KE----GHR----MDKPSNCT-----------NELYM-MMRDCWHAVPSQRPTFKQLVEDL-------------
-------LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAV---TVAV-KML---K-D--D-AT-EKD-LSD-LV-S-EMEMMKMIGKHKNIINLLGACT--QDGP--LYVIVEYASKGNLREYLR---------ARRPPGMEY-----------------------------------------------------SYDINRVPE-EQMTFKDLVSCTYQLARGMEYLAS--Q--K---CIHRDLAARNVLVT-E-----NN-VM---------KIADFGLARDI-------------N---N--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRV---YTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI---PVEELFKLL----KE----GHR----MDKPANCT-----------NELYM-MMRDCWHAVPSQRPTFKQLVEDL-------------
-------LTLGKPLGEGCFGQVVMAEAIGI---------DKDRAAKPV---TVAV-KML---K-D--D-AT-DKD-LSD-LV-S-EMEMMKMIGKHKNIINLLGACT--QGGP--LYVLVEYAAKGNLREFLR---------ARRPPGLDY-----------------------------------------------------SFDTCKPPE-EQLTFKDLVSCAYQVARGMEYLAS--Q--K---CIHRDLAARNVLVT-E-----DN-VM---------KIADFGLARDV-------------H---N--LDYY--------------KKTTNGRLPVKWMAPEALF-----DRV---YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI---PVEELFKLL----KE----GHR----MDKPANCT-----------HDLYM-IMRECWHAAPSQRPTFKQLVEDL-------------
------L-VLGKPLGEGCFGQVVRAEAFGM---------DPARPDQAS---TVAV-KML---K-D--N-AS-DKD-LAD-LV-S-EMEVMKLIGRHKNIINLLGVCT--QEGP--LYVIVECAAKGNLREFLR---------ARRPPGPDL-----------------------------------------------------SPDGPRSSE-GPLSFPVLVSCAYQVARGMQYLES--R--K---CIHRDLAARNVLVT-E-----DN-VM---------KIADFGLARGV-------------H---H--IDYY--------------KKTSNGRLPVKWMAPEALF-----DRV---YTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI---PVEELFSLL----RE----GHR----MDRPPHCP-----------PELYG-LMRECWHAAPSQRPTFKQLVEAL-------------
-------LQLIKRLGNGQFGEVWMGTWN-----------------GNT---KVAI-KTL---K-P--G-TM-SP---ES-FL-E-EAQIMKKL-KHDKLVQLYAVVS---EEP--IYIVTEYMNKGSLLDFLK---------DG-------------------------------------------------------------------EG-RALKLPNLVDMAAQVAAGMAYIER--M--N---YIHRDLRSANILVG-N-----GL-IC---------KIADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILLTELVTKGR-VP---------------YPGM---NNREVLEQV----ER----GYR----MPCPQDCP-----------ISLHE-LMIHCWKKDPEERPTFEYLQSFL-------------
-------LKLEKKLGAGQFGEVWMATYN-----------------KHT---KVAV-KTM---K-P--G-SM-SV---EA-FL-A-EANVMKTL-QHDKLVKLHAVVT---KEP--IYIITEFMAKGSLLDFLK---------SD-------------------------------------------------------------------EG-SKQPLPKLIDFSAQIAEGMAFIEQ--R--N---YIHRDLRAANILVS-A-----SL-VC---------KIADFGLARVI-----------------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----FGS---FTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM---SNPEVIRAL----ER----GYR----MPRPENCP-----------EELYN-IMMRCWKNRPEERPTFEYIQSV--L-----------
-------ITMSRELGQGSFGMVYEGVAKG-----------VVKDEPET---RVAI-KTV---N-E--A-AS-MRE-RIE-FL-N-EASVMKEF-NCHHVVRLLGVVS--QGQP--TLVIMELMTRGDLKSYLR---------SLRPEM-----------------------------------------------------------ENNPVL-APPSLSKMIQMAGEIADGMAYLNA--N--K---FVHRDLAARNCMVA-E-----DF-TV---------KIGDFGMTRDI-------------Y---E--TDYY--------------RKGGKGLLPVRWMSPESLK-----DGV---FTTYSDVWSFGVVLWEIATLAE-QP---------------YQGL---SNEQVLRFV----ME----GGL----LDKPDNCP-----------DMLFE-LMRMCWQYNPKMRPSFLEIISS--I-----------
-------ITLLRELGQGSFGMVYEGNARD-----------IIKGEAET---RVAV-KTV---N-E--S-AS-LRE-RIE-FL-N-EASVMKGF-TCHHVVRLLGVVS--KGQP--TLVVMELMAHGDLKSYLR---------SLRPEA-----------------------------------------------------------ENNPGR-PPPTLQEMIQMAAEIADGMAYLNA--K--K---FVHRDLAARNCMVA-H-----DF-TV---------KIGDFGMTRDI-------------Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGV---FTTSSDMWSFGVVLWEITSLAE-QP---------------YQGL---SNEQVLKFV----MD----GGY----LDQPDNCP-----------ERVTD-LMRMCWQFNPKMRPTFLEIVNLL-------------
------I-SIIRELGQGSFGMVYEGLARG-----------LEAGEEST---PVAL-KTV---N-E--L-AS-PRE-CIE-FL-K-EASVMKAF-KCHHVVRLLGVVS--QGQP--TLVIMELMTRGDLKSHLR---------SLRPEA-----------------------------------------------------------ENNPGL-PQPALGEMIQMAGEIADGMAYLAA--N--K---FVHRDLAARNCMVS-Q-----DF-TV---------KIGDFGMTRDV-------------Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGI---FTTHSDVWSFGVVLWEIVTLAE-QP---------------YQGL---SNEQVLKFV----MD----GGV----LEELEGCP-----------LQLQE-LMSRCWQPNPRLRPSFTHILD---SI----------
-------LTFVQEIGSGQFGLVHLGYWL-----------------NKD---KVAI-KTI---R-E--G-AM-SE---ED-FI-E-EAEVMMKL-SHPKLVQLYGVCL--EQAP--ICLVFEFMEHGCLSDYLR---------TQ--------------------------------------------------------------------R-GLFAAETLLGMCLDVCEGMAYLEE--A--C---VIHRDLAARNCLVG-E-----NQ-VI---------KVSDFGMTRFV-----------------L--DDQY--------------TSSTGTKFPVKWASPEVFS-----FSR---YSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR---SNSEVVEDI----ST----GFR----LYKPRLAS-----------THVYQ-IMNHCWKERPEDRPAFSRLLRQL-------------
------L-KRIRDLGEGHFGKVELCRYDP------------EGDNTGE---QVAV-KSL---K-P--E-SG-GNH-IAD-LK-K-EIEILRNL-YHENIVKYKGICT-ED-GGNGIKLIMEFLPSGSLKEYLP---------KN--------------------------------------------------------------------K-NKINLKQQLKYAVQICKGMDYLGS--R--Q---YVHRDLAARNVLVE-S-----EH-QV---------KIGDFGLTKAI------------ET---D--KEYY--------------TVKDDRDSPVFWYAPECLM-----QSK---FYIASDVWSFGVTLHELLTYCD-SDSSPMALF-LKMIGPTHGQM---TVTRLVNTL----KE----GKR----LPCPPNCP-----------DEVYQ-LMRKCWEFQPSNRTSFQNLIE---GF----------
-------LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGE---VVAV-KKL---Q-H--S-TE--EH-LRD-FE-R-EIEILKSL-QHDNIVKYKGVCYSAGRRN--LKLIMEYLPYGSLRDYLQ---------KH--------------------------------------------------------------------K-ERIDHIKLLQYTSQICKGMEYLGT--K--R---YIHRDLATRNILVE-N-----EN-RV---------KIGDFGLTKVL------------PQ---D--KEYY--------------KVKEPGESPIFWYAPESLT-----ESK---FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM---IVFHLIELL----KN----NGR----LPRPDGCP-----------DEIYM-IMTECWNNNVNQRPSFRDLA----LRV---------
------L-KYISQLGKGNFGSVELCRYDP------------LGDNTGA---LVAV-KQL---Q-H--S-GP-DQ--QRD-FQ-R-EIQILKAL-HSDFIVKYRGVSYGPGRQS--LRLVMEYLPSGCLRDFLQ---------RH--------------------------------------------------------------------R-ARLDASRLLLYSSQICKGMEYLGS--R--R---CVHRDLAARNILVE-S-----EA-HV---------KIADFGLAKLL------------PL---D--KDYY--------------VVREPGQSPIFWYAPESLS-----DNI---FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDV-P-ALCRLLELL----EE----GQR----LPAPPACP-----------AEVHE-LMKLCWAPSPQDRPSFSALGP---QL----------
-------LKLVERLGAGQFGEVWMGYYN-----------------GHT---KVAV-KSL---K-Q--G-SM-SP---DA-FL-A-EANLMKQL-QHQRLVRLYAVVT---QEP--IYIITEYMENGSLVDFLK---------TP-------------------------------------------------------------------SG-IKLTINKLLDMAAQIAEGMAFIEE--R--N---YIHRDLRAANILVS-D-----TL-SC---------KIADFGLARLI-----------------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----YGT---FTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM---TNPEVIQNL----ER----GYR----MVRPDNCP-----------EELYQ-LMRLCWKERPEDRPTFDYLRSV--L-----------
-----LI--HGEVLGKGCFGQAIKVTHR----------------ETGE---VMVM-KEL---I----R-FD-EET-QRT-FL-K-EVKVMRCL-EHPNVLKFIGVLY--KDKR--LNFITEYIKGGTLRGIIK---------SM--------------------------------------------------------------------D-SQYPWSQRVSFAKDIASGMAYLHS--M--N---IIHRDLNSHNCLVR-E-----NK-NV---------VVADFGLARLM-------------V---D--EKTQPEGLRS--LKKPDRKKRYTVVGNPYWMAPEMIN-----GRS---YDEKVDVFSFGIVLCEIIGRVN-AD---------------PDYL-P-RTMDFGLNV----RG----FLD----RYCPPNCP-----------PSFFP-ITVRCCDLDPEKRPSFVKLEH---WL----------
-----LI--HGEVLGKGFFGQAIKVTHK-----------------ATG---KVMVMKEL-----I--R-CD-EET-QKT-FL-T-EVKVMRSL-DHPNVLKFIGVLY--KDKK--LNLLTEYIEGGTLKDFLR---------SM----------------------------------------------------------------------DPFPWQQKVRFAKGIASGMAYLHS--M--C---IIHRDLNSHNCLIK-L-----DK-TV---------VVADFGLSRLIVEERKRAPMEKATT---------KKRTL-----RKNDRKKRYTVVGNPYWMAPEMLN-----GKS---YDETVDIFSFGIVLCEIIGQVY-AD---------------PDCL-P-RTLDFGLNV----KL----FWE----KFVPTDCP-----------PAFFP-LAAICCRLEPESRPAFSKLED---SF----------
------V-TLLRALGHGAFGEVYEGLVIG-----------LPGDSSPL---QVAI-KTL---P-E--L-CS-PQD-ELD-FL-M-EALIISKF-RHQNIVRCVGLSL--RATP--RLILLELMSGGDMKSFLR---------HSRP--------------------------------------------------------------HLGQP-SPLVMRDLLQLAQDIAQGCHYLEE--N--H---FIHRDIAARNCLLS-CA--GPSR-VA---------KIGDFGMARDI-------------Y---R--ASYY--------------RRGDRALLPVKWMPPEAFL-----EGI---FTSKTDSWSFGVLLWEIFSLGY-MP---------------YPGR---TNQEVLDFV----VG----GGR----MDPPRGCP-----------GPVYR-IMTQCWQHEPELRPSFASILERL-------------
-------IEVEEVVGRGAFGVVCKAKWR------------------AK---DVAI-KQI---E-------S-ESE-RKA-FI-V-ELRQLSRV-NHPNIVKLYGACL----NP--VCLVMEYAEGGSLYNVLH---------GA-------------------------------------------------------------------EPLPYYTAAHAMSWCLQCSQGVAYLHS--M--QPKALIHRDLKPPNLLLV-A-----GGTVL---------KICDFGTACDI-----------------------Q--------------THMTNNKGSAAWMAPEVFE-----GSN---YSEKCDVFSWGIILWEVITR-R-KP---------------FDEIGG-PAFRIMWAV----HN----GTR----PPLIKNLP-----------KPIES-LMTRCWSKDPSQRPSMEEIVKI--M-----------
-------LTLGAQIGEGEFGAVLQGEYL------------------GQ---KVAV-KNI---K-C--D-VT-AQ----A-FL-D-ETAVMTKM-QHENLVRLLGVIL---HQG--LYIVMEHVSKGNLVNFLR---------TR-------------------------------------------------------------------GR-ALVNTAQLLQFSLHVAEGMEYLES--K--K---LVHRDLAARNILVS-E-----DL-VA---------KVSDFGLAKAE-----------------------R--------------KGLDSSRLPVKWTAPEALK-----HGK---FTSKSDVWSFGVLLWEVFSYGR-AP---------------YPKM---SLKEVSEAV----EK----GYR----MEPPEGCP-----------GPVHV-LMSSCWEAEPARRPPFRKLAEKL-------------
-------VHFNEVIGRGHFGCVYHGTLL-------------DNDGKKI---HCAV-KSL---N-R--I-TD-IGE-VSQ-FL-T-EGIIMKDF-SHPNVLSLLGICL-RSEGS--PLVVLPYMKHGDLRNFIR---------NE--------------------------------------------------------------------T-HNPTVKDLIGFGLQVAKGMKYLAS--K--K---FVHRDLAARNCMLD-E-----KF-TV---------KVADFGLARDM-------------Y---D--KEYYS------------VHNKTGAKLPVKWMALESLQ-----TQK---FTTKSDVWSFGVLLWELMTRGA-PP---------------YPDV---NTFDITVYL----LQ----GRR----LLQPEYCP-----------DPLYE-VMLKCWHPKAEMRPSFSELVSR--I-----------
------I-EYVRDIGEGAFGRVFQARAPG-----------LLPYEPFT---MVAV-KML---K-E--E-AS-ADM-QAD-FQ-R-EAALMAEF-DNPNIVKLLGVCA--VGKP--MCLLFEYMAYGDLNEFLR---------SMSPHTVCSLSHS---------------------------------------------DLSMRAQVSSPGP-PPLSCAEQLCIARQVAAGMAYLSE--R--K---FVHRDLATRNCLVG-E-----NM-VV---------KIADFGLSRNI-------------Y---S--ADYY--------------KANENDAIPIRWMPPESIF-----YNR---YTTESDVWAYGVVLWEIFSYGL-QP---------------YYGM---AHEEVIYYV----RD----GNI----LSCPENCP-----------VELYN-LMRLCWSKLPADRPSFTSIHRIL-------------
-------YVLQQKLGSGSFGTVYLVSDK----------------KAKRGEELKVL-KEI---SVG--E-LNPNE---TV-QANL-EAQLLSKL-DHPAIVKFHASFV--EQDN--FCIITEYCEGRDLDDKIQEY----KQAGK-----------------------------------------------------------------------IFPENQIIEWFIQLLLGVDYMHE--R--R---ILHRDLKSKNVFLK-------NN-LL---------KIGDFGVSRLL-----------------MGSCDLA--------------TT---LTGTPHYMSPEALK-----HQG---YDTKSDIWSLACILYEMCC-MN-HA---------------FAGS------NFLSIV----LK----IVE----GDTPSLPERY-P-------KELNA-IMESMLNKNPSLRPSAIEILKIPYL-----------
-------YDVIKAIGQGAFGKAYLAKGK----------------SDSK---HCVI-KEI---NFE--K-MPIQE---KE-ASKK-EVILLEKM-KHPNIVAFFNSFQ--ENGR--LFIVMEYCDGGDLMKRINR------QRGV-----------------------------------------------------------------------LFSEDQILGWFVQISLGLKHIHD--R--K---ILHRDIKAQNIFLS-K-----NG-MV--------AKLGDFGIARVL-----------------NNSMELA--------------RT---CIGTPYYLSPEICQ-----NKP---YNNKTDIWSLGCVLYELCT-LK-HP---------------FEGN------NLQQLV----LK----ICQ----AHFAPISPGF---S-----RELHS-LISQLFQVSPRDRPSINSILKRPFL-----------
-------FRIEKKIGRGQFSEVYRAACL----------------LDGV---PVAL-KKV---QIF--D-LMDAK---AR-ADCIKEIDLLKQL-NHPNVIKYYASFI--EDNE--LNIVLELADAGDLSRMIKHF----KKQKR-----------------------------------------------------------------------LIPERTVWKYFVQLCSALEHMHS--R--R---VMHRDIKPANVFIT-A-----TG-VV---------KLGDLGLGRFF-----------------SSKTTAA--------------HS---LVGTPYYMSPERIH-----ENG---YNFKSDIWSLGCLLYEMAA-LQ-SP---------------FYGD----KMNLYSLC----KK----IEQ----CDYPPLPSDHYS-------EELRQ-LVNMCINPDPEKRPDVTYV------YDVA-------
-------YERIRVVGRGAFGIVHLCLRK----------------ADQK---LVII-KQI---PVE--Q-MTKEE---RQ-AAQN-ECQVLKLL-NHPNVIEYYENFL--EDKA--LMIAMEYAPGGTLAEFIQK------RCNS-----------------------------------------------------------------------LLEEETILHFFVQILLALHHVHT--H--L---ILHRDLKTQNILLDKH-----RM-VV---------KIGDFGISKI------------------LSSKSKA--------------YT---VVGTPCYISPELCE-----GKP---YNQKSDIWALGCVLYELAS-LK-RA---------------FEAA------NLPALV----LK----IMS----GTFAPISDRY---S-----PELRQ-LVLSLLSLEPAQRPPLSHIMAQP--LC---------
-----IV--LKWELGEGAFGKVFLAECHN-----------LLPEQDKM---LVAV-KAL---K-E--A-SE-SA--RQD-FQ-R-EAELLTML-QHQHIVRFFGVCT--EGRP--LLMVFEYMRHGDLNRFLR---------SHGPDAKL------------------------------------------------------LAGGEDVAP-GPLGLGQLLAVASQVAAGMVYLAG--L--H---FVHRDLATRNCLVG-Q-----GL-VV---------KIGDFGMSRDI-------------Y---S--TDYY--------------RVGGRTMLPIRWMPPESIL-----YRK---FTTESDVWSFGVVLWEIFTYGK-QP---------------WYQL---SNTEAIDCI----TQ----GRE----LERPRACP-----------PEVYA-IMRGCWQREPQQRHSIKDVHARL-------------
------I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKI---LVAV-KTL---K-D--A-SD-NA--RKD-FH-R-EAELLTNL-QHEHIVKFYGVCV--EGDP--LIMVFEYMKHGDLNKFLR---------AHGPDAV--------------------------------------------------------LMAEGNPP-TELTQSQMLHIAQQIAAGMVYLAS--Q--H---FVHRDLATRNCLVG-E-----NL-LV---------KIGDFGMSRDV-------------Y---S--TDYY--------------RVGGHTMLPIRWMPPESIM-----YRK---FTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL---SNNEVIECI----TQ----GRV----LQRPRTCP-----------QEVYE-LMLGCWQREPHMRKNIKGIHTL--L-----------
------I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKM---LVAV-KAL---K-D--P-TL-AA--RKD-FQ-R-EAELLTNL-QHEHIVKFYGVCG--DGDP--LIMVFEYMKHGDLNKFLR---------AHGPDAMIL-----------------------------------------------------VDGQPRQAK-GELGLSQMLHIASQIASGMVYLAS--Q--H---FVHRDLATRNCLVG-A-----NL-LV---------KIGDFGMSRDV-------------Y---S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----YRK---FTTESDVWSFGVILWEIFTYGK-QP---------------WFQL---SNTEVIECI----TQ----GRV----LERPRVCP-----------KEVYD-VMLGCWQREPQQRLNIKEIYKIL-------------
-------YELQEVIGSGATAVVQAAYCA----------------PKKE---KVAI-KRI---NLE--K-CQTSM---DE--LLK-EIQAMSQC-HHPNIVSYYTSFV--VKDE--LWLVMKLLSGGSVLDIIKHIVAKGEHKSG-----------------------------------------------------------------------VLDESTIATILREVLEGLEYLHK--N--G---QIHRDVKAGNILLG-E-----DG-SV---------QIADFGVSAFLAT------------GGDITRNKVR--------------KT---FVGTPCWMAPEVME----QVRG---YDFKADIWSFGITAIELAT-GA-AP---------------YHKY---PPMKVLMLT----LQ----NDP----PSLETGVQDKE--MLKKYGKSFRK-MISLCLQKDPEKRPTAAELLRHKFF-----------
------F-KFGKILGEGSFSTVVLAREL----------------ATSR---EYAI-KIL---EKR--H-IIKEN---KVPYVTR-ERDVMSRL-DHPFFVKLYFTFQ--DDEK--LYFGLSYAKNGELLKYIR--------KIG-----------------------------------------------------------------------SFDETCTRFYTAEIVSALEYLHG--K--G---IIHRDLKPENILLN-E-----DM-HI---------QITDFGTAKVLS---------------PESKQARA--------------NS---FVGTAQYVSPELLT-----EKS---ACKSSDLWALGCIIYQLVA-GL-PP---------------FRAG------NEYLIF----QK----IIK----LEYDFPEKFF---------PKARD-LVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
-------IELGRCIGEGQFGDVHQGIYM-------------SPENPAL---AVAI-KTC---K-N--C-TS-DSV-REK-FL-Q-EALTMRQF-DHPHIVKLIGVIT---ENP--VWIIMELCTLGELRSFLQ---------VR--------------------------------------------------------------------K-YSLDLASLILYAYQLSTALAYLES--K--R---FVHRDIAARNVLVS-S-----ND-CV---------KLGDFGLSRYM-----------------E--DSTY--------------YKASKGKLPIKWMAPESIN-----FRR---FTSASDVWMFGVCMWEILMHGV-KP---------------FQGV---KNNDVIGRI----EN----GER----LPMPPNCP-----------PTLYS-LMTKCWAYDPSRRPRFTELKAQL-------------
------F-TLCRKLGSGYFGEVFEGLWK-----------------DRV---QVAI-KVI---S-R--D-NL-LH--QQM-LQ-S-EIQAMKKL-RHKHILALYAVVS--VGDP--VYIITELMAKGSLLELLR---------DS-------------------------------------------------------------------DE-KVLPVSELLDIAWQVAEGMCYLES--Q--N---YIHRDLAARNILVG-E-----NT-LC---------KVGDFGLARLI--------------------KEDV--------------YLSHDHNIPYKWTAPEALS-----RGH---YSTKSDVWSFGILLHEMFSRGQ-VP---------------YPGM---SNHEAFLRV----DA----GYR----MPCPLECP-----------PSVHK-LMLTCWCRDPEQRPCFKALRERL-------------
-----VM--LSTRIGSGSFGTVYKGKWH-------------------G---DVAV-KIL---K-V-VD-PT-PEQ-FQA-FR-N-EVAVLRKT-RHVNILLFMGYMT---KDN--LAIVTQWCEGSSLYKHLH---------VQ--------------------------------------------------------------------E-TKFQMFQLIDIARQTAQGMDYLHA--K--N---IIHRDMKSNNIFLH-E-----GL-TV---------KIGDFGLATVK-------------S---R--WSGS--------------QQVEQPTGSVLWMAPEVIR-----MQDNNPFSFQSDVYSYGIVLYELMT-GE-LP---------------YSHI-N-NRDQIIFMV----GR----GYASPDLSKLYKNCP-----------KAMKR-LVADCVKKVKEERPLFPQILSS--I-----------
------L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYT---TVAV-KML---K-E--N-AS-PSE-LRD-LL-S-EFNVLKQV-NHPHVIKLYGACS--QDGP--LLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSG---------------------------------------------GSRNSSSLDHPDE-RALTMGDLISFAWQISQGMQYLAE--M--K---LVHRDLAARNILVA-E-----GR-KM---------KISDFGLSRDV-------------Y---E--EDSY--------------VKRSQGRIPVKWMAIESLF-----DHI---YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI---PPERLFNLL----KT----GHR----MERPDNCS-----------EEMYR-LMLQCWKQEPDKRPVFADISKDL-------------
---FTGW----EKVGSGGFGQVYKVRHV----------------HWKT---WLAI-KCS---PSL--H-VDDRE---RM-ELLE-EAKKMEMA-KFRYILPVYGIC----REP--VGLVMEYMETGSLEKLLA---------SE-----------------------------------------------------------------------PLPWDLRFRIIHETAVGMNFLHC--MAPP---LLHLDLKPANILLD-A-----HY-HV---------KISDFGLAKCNG--------------LSHSHDLSM--------------DG---LFGTIAYLPPERIR---EKSRL---FDTKHDVYSFAIVIWGVLT-QK-KP---------------FADE--KNILHIMVKV----VK----GHR----PELPPVCRARPRAC-----SHLIR-LMQRCWQGDPRVRPTFQ--------GNGLN------
-----LT--LRLLLGSGAFGEVYEGTAVDI----------LGVGSGEI---KVAV-KTL---K-K--G-ST-DQE-KIE-FL-K-EAHLMSKF-NHPNILKQLGVCL--LNEP--QYIILELMEGGDLLTYLR---------KARM--------------------------------------------------------------ATFYG-PLLTLVDLVDLCVDISKGCVYLER--M--H---FIHRDLAARNCLVS-VKDYTSPR-IV---------KIGDFGLARDI-------------Y---K--NDYY--------------RKRGEGLLPVRWMAPESLM-----DGI---FTTQSDVWSFGILIWEILTLGH-QP---------------YPAH---SNLDVLNYV----QT----GGR----LEPPRNCP-----------DDLWN-LMTQCWAQEPDQRPTFHRIQDQL-------------
-------WEIIGELGDGAFGKVYKAQNK----------------ETSV---LAAA-KVI---DTK--S-EEELE---DY-M--V-EIDILASC-DHPNIVKLLDAFY--YENN--LWILIEFCAGGAVDAVML-------ELER-----------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHD--N--K---IIHRDLKAGNILFT-L-----DG-DI---------KLADFGVSAKN-----------------TRTIQRR--------------DS---FIGTPYWMAPEVVMCETSKDRP---YDYKADVWSLGITLIEMAE-IE-PP---------------HHEL---NPMRVLLKI----AK----SEP----PTLAQPSRWS---------SNFKD-FLKKCLEKNVDARWTTSQLLQHPFV-----------
------L-RLEVKLGQGCFGEVWMGTWN-----------------GTT---RVAI-KTL---K-P--G-TM-SP---EA-FL-Q-EAQVMKKL-RHEKLVQLYAVVS---EEP--IYIVTEYMSKGSLLDFLK---------GE-------------------------------------------------------------------TG-KYLRLPQLVDMAAQIASGMAYVER--M--N---YVHRDLRAANILVG-E-----NL-VC---------KVADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM---VNREVLDQV----ER----GYR----MPCPPECP-----------ESLHD-LMCQCWRKEPEERPTFEYLQAF--L-----------
-----FA--LGRKLGEGYFGEVWEGLWL-----------------GSL---PVAI-KVI---K-S--A-NM-K---LTD-LA-K-EIQTLKGL-RHERLIRLHAVCS--GGEP--VYIVTELMRKGNLQAFLG---------TP-------------------------------------------------------------------EG-RALRLPPLLGFACQVAEGMSYLEE--Q--R---VVHRDLAARNVLVD-D-----GL-AC---------KVADFGLARLL-----------------K--DDIY--------------SPSSSSKIPVKWTAPEAAN-----YRV---FSQKSDVWSFGVLLHEVFTYGQ-CP---------------YEGM---TNHETLQQI----MR----GYR----LPRPAACP-----------AEVYV-LMLECWRSSPEERPSFATLREKL-------------
-------WEIVGELGDGAFGKVYKAKNK----------------ETGA---LAAA-KVI---ETK--S-EEELE---DY-I--V-EIEILATC-DHPYIVKLLGAYY--HDGK--LWIMIEFCPGGAVDAIML-------ELDR-----------------------------------------------------------------------GLTEPQIQVVCRQMLEALNFLHS--K--R---IIHRDLKAGNVLMT-L-----EG-DI---------RLADFGVSAKN-----------------LKTLQKR--------------DS---FIGTPYWMAPEVVMCETMKDTP---YDYKADIWSLGITLIEMAQ-IE-PP---------------HHEL---NPMRVLLKI----AK----SDP----PTLLTPSKWS---------VEFRD-FLKIALDKNPETRPSAAQLLEHPFV-----------
-------FTKLEKIGKGSFGEVFKGIDN----------------RTQK---VVAI-KII---DLE--E-AEDEI---ED-IQ-Q-EITVLSQC-DSPYVTKYYGSYL--KDTK--LWIIMEYLGGGSALDLLE---------PG-----------------------------------------------------------------------PLDETQIATILREILKGLDYLHS--E--K---KIHRDIKAANVLLS-E-----HG-EV---------KLADFGVAGQL-----------------TDTQIKR--------------NT---FVGTPFWMAPEVIK-----QSA---YDSKADIWSLGITAIELAR-GE-PP---------------HSEL---HPMKVLFLI----PK----NNP----PTLEGNYS-----------KPLKE-FVEACLNKEPSFRPTAKELLKHKFI-----------
------F-DVLEKLGEGSYGSVFKAIHK----------------ESGQ---VVAI-KQV---PVE--S-DLQEI--------IK-EISIMQQC-DSPYVVKYYGSYF--KNTD--LWIVMEYCGAGSVSDIIR-------LRNK-----------------------------------------------------------------------TLIEDEIATILKSTLKGLEYLHF--M--R---KIHRDIKAGNILLN-T-----EG-HA---------KLADFGVAGQL-----------------TDTMAKR--------------NT---VIGTPFWMAPEVIQ-----EIG---YNCVADIWSLGITSIEMAE-GK-PP---------------YADI---HPMRAIFMI----PT----NPP----PTFRKPELWS---------DDFTD-FVKKCLVKNPEQRATATQLLQHPFI-----------
-------YELQEVIGSGATAVVQAALCK----------------PRQE---RVAI-KRI---NLE--K-CQTSM---DE--LLK-EIQAMSQC-SHPNVVTYYTSFV--VKDE--LWLVMKLLSGGSMLDIIKYIVNRGEHKNG-----------------------------------------------------------------------VLEEAIIATILKEVLEGLDYLHR--N--G---QIHRDLKAGNILLG-E-----DG-SV---------QIADFGVSAFLAT------------GGDVTRNKVR--------------KT---FVGTPCWMAPEVME----QVRG---YDFKADMWSFGITAIELAT-GA-AP---------------YHKY---PPMKVLMLT----LQ----NDP----PTLETGVEDKE--MMKKYGKSFRK-LLSLCLQKDPSKRPTAAELLKCKFF-----------
------F-DVLEKLGEGSYGSVYKAIHK----------------ETGQ---IVAI-KQV---PVE--S-DLQEI--------IK-EISIMQQC-DSPHVVKYYGSYF--KNTD--LWIVMEYCGAGSVSDIIR-------LRNK-----------------------------------------------------------------------TLTEDEIATILQSTLKGLEYLHF--M--R---KIHRDIKAGNILLN-T-----EG-HA---------KLADFGVAGQL-----------------TDTMAKR--------------NT---VIGTPFWMAPEVIQ-----EIG---YNCVADIWSLGITAIEMAE-GK-PP---------------YADI---HPMRAIFMI----PT----NPP----PTFRKPELWS---------DNFTD-FVKQCLVKSPEQRATATQLLQHPFV-----------
----TLE---DKELGSGNFGTVKKGYYQ--------------MKKVVK---TVAV-KIL---K-N--E-AN-DPALKDE-LL-A-EANVMQQL-DNPYIVRMIGICE---AES--WMLVMEMAELGPLNKYLQ---------QN----------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEE--S--N---FVHRDLAARNVLLV-T-----QH-YA---------KISDFGLSKAL-------------R---A--DENY-------------YKAQTHGKWPVKWYAPECIN-----YYK---FSSKSDVWSFGVLMWEAFSYGQ-KP---------------YRGM---KGSEVTAML----EK----GER----MGCPAGCP-----------REMYD-LMNLCWTYDVENRPGFAAVE----LRL---------
-------LTFMRELGSGLFGVVRLGKWR-----------------AQY---KVAI-KAI---R-E--G-AM-CE---ED-FI-E-EAKVMMKL-THPKLVQLYGVCT--QQKP--IYIVTEFMERGCLLNFLR---------QR--------------------------------------------------------------------Q-GHFSRDVLLSMCQDVCEGMEYLER--N--S---FIHRDLAARNCLVS-E-----AG-VV---------KVSDFGMARYV-----------------L--DDQY--------------TSSSGAKFPVKWCPPEVFN-----YSR---FSSKSDVWSFGVLMWEVFTEGR-MP---------------FEKY---TNYEVVTMV----TR----GHR----LYQPKLAS-----------NYVYE-VMLRCWQEKPEGRPSFEDLLRT--I-----------
-------IKFQDVIGEGNFGQVLKARIK--------------KDGLRM---DAAI-KRM---K-E--Y-AS-KDD-HRD-FA-G-ELEVLCKLGHHPNIINLLGACE--HRGY--LYLAIEYAPHGNLLDFLR---------KSRVLETDP-----------------------------------------------------AFAIANSTA-STLSSQQLLHFAADVARGMDYLSQ--K--Q---FIHRDLAARNILVG-E-----NY-VA---------KIADFGLSRGQ---------------------EVY--------------VKKTMGRLPVRWMAIESLN-----YSV---YTTNSDVWSYGVLLWEIVSLGG-TP---------------YCGM---TCAELYEKL----PQ----GYR----LEKPLNCD-----------DEVYD-LMRQCWREKPYERPSFAQILV---SL----------
-------ITFEDLIGEGNFGQVIRAMIK--------------KDGLKM---NAAI-KML---K-E--Y-AS-END-HRD-FA-G-ELEVLCKLGHHPNIINLLGACK--NRGY--LYIAIEYAPYGNLLDFLR---------KSRVLETDP-----------------------------------------------------AFAREHGTA-STLSSRQLLRFASDAANGMQYLSE--K--Q---FIHRDLAARNVLVG-E-----NL-AS---------KIADFGLSRGE---------------------EVY--------------VKKTMGRLPVRWMAIESLN-----YSV---YTTKSDVWSFGVLLWEIVSLGG-TP---------------YCGM---TCAELYEKL----PQ----GYR----MEQPRNCD-----------DEVYE-LMRQCWRDRPYERPPFAQIALQ--L-----------
----VCR---GELLGSGCFGVVHRGLWT-------------LPSGKSV---PVAV-KSLRVGP-E--G-PM-GTE-LGD-FL-R-EVSVMMNL-EHPHVLRLHGLVL---GQP--LQMVMELAPLGSLHARLT---------AP------------------------------------------------------------------APT-PPLLVALLCLFLRQLAGAMAYLGA--R--G---LVHRDLATRNLLLA-S-----PR-TI---------KVADFGLVRPL------------GG---A--RGRY--------------VMGGPRPIPYAWCAPESLR-----HGA---FSSASDVWMFGVTLWEMFSGGE-EP---------------WAGV---PPYLILQRL----ED----RAR----LPRPPLCS-----------RALYS-LALRCWAPHPADRPSFSHLE----GLL---------
------L-RLLEKLGDGSFGVVRRGEWD-------------APSGKTV---SVAV-KCL---K-PDVL-SQ-PEA-MDD-FI-R-EVNAMHSL-DHRNLIRLYGVVL---TPP--MKMVTELAPLGSLLDRLR---------KH--------------------------------------------------------------------Q-GHFLLGTLSRYAVQVAEGMGYLES--K--R---FIHRDLAARNLLLA-T-----RD-LV---------KIGDFGLMRAL------------PQ---N--DDHY--------------VMQEHRKVPFAWCAPESLK-----TRT---FSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL---NGSQILHKI---DKE----GER----LPRPEDCP-----------QDIYN-VMVQCWAHKPEDRPTFVALRDF--L-----------
-------IEFHEIIGSGSFGKVYKGRCR------------------NK---IVAI-KRY---R-ANTY-CS-KSD-VDM-FC-R-EVSILCQL-NHPCVIQFVGACL-NDPSQ--FAIVTQYISGGSLFSLLH---------EQ--------------------------------------------------------------------K-RILDLQSKLIIAVDVAKGMEYLHNLTQ--P---IIHRDLNSHNILLY-E-----DG-HA---------VVADFGESRFL-------------Q---S--LD-E--------------DNMTKQPGNLRWMAPEVFT-----QCT--RYTIKADVFSYALCLWEILT-GE-IP---------------FAHL---KPAAAAADM---AYH----HIR----PPIGYSIP-----------KPISS-LLIRGWNACPEGRPEFSEVVMKL-------------
------L-AFIKEIGSGQFGVVHLGEWR-----------------SHI---QVAI-KAI---N-E--G-SM-SE---ED-FI-E-EAKVMMKL-SHSKLVQLYGVCI--QRKP--LYIVTEFMENGCLLNYLR---------EN--------------------------------------------------------------------K-GKLRKEMLLSVCQDICEGMEYLER--N--G---YIHRDLAARNCLVS-S-----TC-IV---------KISDFGMTRYV-----------------L--DDEY--------------VSSFGAKFPIKWSPPEVFL-----FNK---YSSKSDVWSFGVLMWEVFTEGK-MP---------------FENK---SNLQVVEAI----SE----GFR----LYRPHLAP-----------MSIYE-VMYSCWHEKPEGRPTFAELLR---AV----------
-----FS--RKDLIGHGAFAVVFKGRHR----------------EKHD--LEVAV-KCI---NKK--N-LAKSQ---T--LLGK-EIKILKEL-KHENIVALYDFQE--MANS--VYLVMEYCNGGDLADYLH--------AMR-----------------------------------------------------------------------TLSEDTIRLFLQQIAGAMRLLHS--K--G---IIHRDLKPQNILLS-N-----PA-GRRANPNSIRVKIADFGFARY------------------LQSNMMA--------------AT---LCGSPMYMAPEVIM-----SQH---YDGKADLWSIGTIVYQCLT-GK-AP---------------FQAS---SPQDLRLFY----EK----NKT----LVPTIPRETS---------APLRQ-LLLALLQRNHKDRMDFDEFFHHPFL-----------
------L-RLEVKLGQGCFGEVWMGTWN-----------------GTT---KVAI-KTL---K-P--G-TM-MP---EA-FL-Q-EAQIMKKL-RHDKLVPLYAVVS---EEP--IYIVTEFMSKGSLLDFLK---------EG-------------------------------------------------------------------DG-KYLKLPQLVDMAAQIADGMAYIER--M--N---YIHRDLRAANILVG-E-----NL-VC---------KIADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM---VNREVLEQV----ER----GYR----MPCPQGCP-----------ESLHE-LMNLCWKKDPDERPTFEYIQSFL-------------
|