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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FGR 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
Other AURKA 133
TK BLK 241
TK BMX 422
TK BTK 402
TK CSF1R 582
TK CSK 195
TK DDR1 572
TK DDR2 563
TK EGFR 712
TK EPHA1 624
TK EPHA3 621
TK EPHA4 621
TK EPHA5 675
TK EPHA6 631
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB3 633
TK EPHB4 615
TK EPHB6 670
TK ERBB3 709
TK ERBB4 718
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FYN 271
TK HCK 241
TK INSR 1023
TK INSRR 979
TK ITK 363
TK JAK2 849
TK JAK3 822
TK LCK 245
TK LTK 510
TKL MAP3K7 36
TK MATK 235
TK MET 1078
Other NEK11 29
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
TK PTK2 422
TK PTK6 191
TK RET 724
TKL RIPK4 22
STE SLK 34
TK SRC 270
TK SRMS 230
STE STK10 36
STE STK24 24
STE STK3 27
STE STK39 63
STE STK4 30
TK SYK 371
TK TEC 370
TK TEK 824
TK TIE1 839
TK TNK2 150
TKL TNNI3K 463
TK TXK 271
Other ULK1 16
TK YES1 277
-------ITLERRLGTGCFGDVWLGTWN-----------------GST---KVAVKTLK-P--G-TM-SP---KAFL-EEAQVMKLL-RHDKLVQLYAVVS---EEPIYIVTEFMCHGSLLDFLK---------NP-------------------------------------------------------------------EG-QDLRLPQLVDMAAQVAEGMAYMER--M--N---YIHRDLRAANILVGE---RL-AC---------KIADFGLARLI--------K--DDEY--------------NPCQGSKFPIKWTAPEAAL-----FGR-FTIKSDVWSFGILLTELITKGR-IP---------------YPGM---NKREVLEQV----EQ----GYH---MPCPPGCP-----------ASLYE-AMEQTWRLDPEERPTFEYLQSFL-------
-------ITMKHKLGGGQYGEVYEGVWK----------------KYSL---TVAVKTLK-E--D-TM-EV---EEFL-KEAAVMKEI-KHPNLVQLLGVCT--REPPFYIITEFMTYGNLLDYLR---------EC-------------------------------------------------------------------NR-QEVNAVVLLYMATQISSAMEYLEK--K--N---FIHRDLAARNCLVGE---NH-LV---------KVADFGLSRLM--------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNK-FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI---DLSQVYELL----EK----DYR---MERPEGCP-----------EKVYE-LMRACWQWNPSDRPSFAEIHQA--F-----
-------ITMKHKLGGGQYGEVYVGVWK----------------KYSL---TVAVKTLK-E--D-TM-EV---EEFL-KEAAVMKEI-KHPNLVQLLGVCT--LEPPFYIVTEYMPYGNLLDYLR---------EC-------------------------------------------------------------------NR-EEVTAVVLLYMATQISSAMEYLEK--K--N---FIHRDLAARNCLVGE---NH-VV---------KVADFGLSRLM--------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNT-FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI---DLSQVYDLL----EK----GYR---MEQPEGCP-----------PKVYE-LMRACWKWSPADRPSFAETHQA--F-----
------I-TLIRGLGHGAFGEVYEGQVSG-----------MPNDPSPL---QVAVKTLP-E--V-CS-EQD-ELDFL-MEALIISKF-NHQNIVRCIGVSL--QSLPRFILLELMAGGDLKSFLR---------ETRP--------------------------------------------------------------RPSQP-SSLAMLDLLHVARDIACGCQYLEE--N--H---FIHRDIAARNCLLTCPGPGR-VA---------KIGDFGMARDI----Y---R--ASYY--------------RKGGCAMLPVKWMPPEAFM-----EGI-FTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK---SNQEVLEFV----TS----GGR---MDPPKNCP-----------GPVYR-IMTQCWQHQPEDRPNFAIILER--I-----
-------FEIGRPLGKGKFGNVYLAREK----------------QSKF---ILALKVLFKA--QLEKAGV---EHQLRREVEIQSHL-RHPNILRLYGYFH--DATRVYLILEYAPLGTVYRELQ--------KLS-----------------------------------------------------------------------KFDEQRTATYITELANALSYCHS--K--R---VIHRDIKPENLLLGS---AG-EL---------KIADFGWSV----------HAPSSRR--------------TT---LCGTLDYLPPEMIE-----GRM-HDEKVDLWSLGVLCYEFLV-GK-PP---------------FEAN------TYQETY----KR----ISR---VEFTFPDFVT---------EGARD-LISRLLKHNPSQRPMLREVLEHPWI-----
------L-RLVRKLGSGQFGEVWMGYYK-----------------NNM---KVAIKTLK-E--G-TM-SP---EAFL-GEANVMKAL-QHERLVRLYAVVT---KEPIYIVTEYMARGCLLDFLK---------TD-------------------------------------------------------------------EG-SRLSLPRLIDMSAQIAEGMAYIER--M--N---SIHRDLRAANILVSE---AL-CC---------KIADFGLARII-----------DSEY--------------TAQEGAKFPIKWTAPEAIH-----FGV-FTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM---SNPEVIRNL----ER----GYR---MPRPDTCP-----------PELYRGVIAECWRSRPEERPTFEFLQSV--L-----
-------ITLLKELGSGQFGVVQLGKWK-----------------GQY---DVAVKMIK-E--G-SM-SE---DEFF-QEAQTMMKL-SHPKLVKFYGVCS--KEYPIYIVTEYISNGCLLNYLR---------SH--------------------------------------------------------------------G-KGLEPSQLLEMCYDVCEGMAFLES--H--Q---FIHRDLAARNCLVDR---DL-CV---------KVSDFGMTRYV--------L--DDQY--------------VSSVGTKFPVKWSAPEVFH-----YFK-YSSKSDVWAFGILMWEVFSLGK-QP---------------YDLY---DNSQVVLKV----SQ----GHR---LYRPHLAS-----------DTIYQ-IMYSCWHELPEKRPTFQQLLSS--I-----
-------LTFLKELGTGQFGVVKYGKWR-----------------GQY---DVAIKMIK-E--G-SM-SE---DEFI-EEAKVMMNL-SHEKLVQLYGVCT--KQRPIFIITEYMANGCLLNYLR---------EM--------------------------------------------------------------------R-HRFQTQQLLEMCKDVCEAMEYLES--K--Q---FLHRDLAARNCLVND---QG-VV---------KVSDFGLSRYV--------L--DDEY--------------TSSVGSKFPVRWSPPEVLM-----YSK-FSSKSDIWAFGVLMWEIYSLGK-MP---------------YERF---TNSETAEHI----AQ----GLR---LYRPHLAS-----------EKVYT-IMYSCWHEKADERPTFKILLSN--I-----
-------LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVL---KVAVKMLK-S--T-AH-ADE-KEALM-SELKIMSHLGQHENIVNLLGACT--HGGPVLVITEYCCYGDLLNFLR---------RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDG-RPLELRDLLHFSSQVAQGMAFLAS--K--N---CIHRDVAARNVLLTN---GH-VA---------KIGDFGLARDI----M---N--DSNY--------------IVKGNARLPVKWMAPESIF-----DCV-YTVQSDVWSYGILLWEIFSLGL-NP---------------YPGI-L-VNSKFYKLV----KD----GYQ---MAQPAFAP-----------KNIYS-IMQACWALEPTHRPTFQQICSFL-------
-------LKLLQTIGKGEFGDVMLGDYR------------------GN---KVAVKCIK-N--D-AT-AQ----AFL-AEASVMTQL-RHSNLVQLLGVIV-EEKGGLYIVTEYMAKGSLVDYLR---------SR-------------------------------------------------------------------GR-SVLGGDCLLKFSLDVCEAMEYLEG--N--N---FVHRDLAARNVLVSE---DN-VA---------KVSDFGLTKEA--------------S--------------STQDTGKLPVKWTAPEALR-----EKK-FSTKSDVWSFGILLWEIYSFGR-VP---------------YPRI---PLKDVVPRV----EK----GYK---MDAPDGCP-----------PAVYE-VMKNCWHLDAAMRPSFLQLREQL-------
-------LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPL---LVAVKILR-P--D-AT-KNA-RNDFL-KEVKIMSRL-KDPNIIRLLGVCV--QDDPLCMITDYMENGDLNQFLS---------AHQLEDKAAE--------------------------------------------------GAPGDGQAAQG-PTISYPMLLHVAAQIASGMRYLAT--L--N---FVHRDLATRNCLVGE---NF-TI---------KIADFGMSRNL----Y---A--GDYY--------------RVQGRAVLPIRWMAWECIL-----MGK-FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL---TDEQVIENAGEFFRD----QGRQVYLSRPPACP-----------QGLYE-LMLRCWSRESEQRPPFSQLHRFL-------
-------LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPV---LVAVKMLR-A--D-AN-KNA-RNDFL-KEIKIMSRL-KDPNIIHLLAVCI--TDDPLCMITEYMENGDLNQFLS---------RHEPPN-----------------------------------------------------------SSSSDV-RTVSYTNLKFMATQIASGMKYLSS--L--N---FVHRDLATRNCLVGK---NY-TI---------KIADFGMSRNL----Y---S--GDYY--------------RIQGRAVLPIRWMSWESIL-----LGK-FTTASDVWAFGVTLWETFTFCQEQP---------------YSQL---SDEQVIENT----GEFFRDQGRQTYLPQPAICP-----------DSVYK-LMLSCWRRDTKNRPSFQEIHL---LL----
------F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKI---PVAIKELR-E--A-TS-PKA-NKEIL-DEAYVMASV-DNPHVCRLLGICL---TSTVQLITQLMPFGCLLDYVR---------EH--------------------------------------------------------------------K-DNIGSQYLLNWCVQIAKGMNYLED--R--R---LVHRDLAARNVLVKT---PQ-HV---------KITDFGLAKLL----G---A--EEKE--------------YHAEGGKVPIKWMALESIL-----HRI-YTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI---PASEISSIL----EK----GER---LPQPPICT-----------IDVYM-IMVKCWMIDADSRPKFRELI----IEF---
-----LM--VDTVIGEGEFGEVYRGTLR-------------LPSQDCK---TVAIKTLK-D--T-SP-GGQ-WWNFL-REATIMGQF-SHPHILHLEGVVT--KRKPIMIITEFMENGALDAFLR---------ER--------------------------------------------------------------------E-DQLVPGQLVAMLQGIASGMNYLSN--H--N---YVHRDLAARNILVNQ---NL-CC---------KVSDFGLTRLL----D---D--FDGT--------------YETQGGKIPIRWTAPEAIA-----HRI-FTTASDVWSFGIVMWEVLSFGD-KP---------------YGEM---SNQEVMKSI----ED----GYR---LPPPVDCP-----------APLYE-LMKNCWAYDRARRPHFQKLQAHL-------
------I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEI---SVAIKTLK-V--G-YT-EKQ-RRDFL-GEASIMGQF-DHPNIIRLEGVVT--KSKPVMIVTEYMENGSLDSFLR---------KH--------------------------------------------------------------------D-AQFTVIQLVGMLRGIASGMKYLSD--M--G---YVHRDLAARNILINS---NL-VC---------KVSDFGLSRVL----E---D--DPEA-------------AYTTRGGKIPIRWTSPEAIA-----YRK-FTSASDVWSYGIVLWEVMSYGE-RP---------------YWEM---SNQDVIKAV----DE----GYR---LPPPMDCP-----------AALYQ-LMLDCWQKDRNNRPKFEQIVSIL-------
-------IKIEKVIGVGEFGEVCSGRLK-------------VPGKREI---CVAIKTLK-A--G-YT-DKQ-RRDFL-SEASIMGQF-DHPNIIHLEGVVT--KCKPVMIITEYMENGSLDAFLR---------KN--------------------------------------------------------------------D-GRFTVIQLVGMLRGIGSGMKYLSD--M--S---YVHRDLAARNILVNS---NL-VC---------KVSDFGMSRVL----E---D--DPEA-------------AYTTRGGKIPIRWTAPEAIA-----YRK-FTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM---SNQDVIKAI----EE----GYR---LPPPMDCP-----------IALHQ-LMLDCWQKERSDRPKFGQIVNML-------
-------ITIERVIGAGEFGEVCSGRLK-------------LPGKREL---PVAIKTLK-V--G-YT-EKQ-RRDFL-GEASIMGQF-DHPNIIHLEGVVT--KSKPVMIVTEYMENGSLDTFLK---------KN--------------------------------------------------------------------D-GQFTVIQLVGMLRGISAGMKYLSD--M--G---YVHRDLAARNILINS---NL-VC---------KVSDFGLSRVL----E---D--DPEA-------------AYTTRGGKIPIRWTAPEAIA-----FRK-FTSASDVWSYGIVMWEVVSYGE-RP---------------YWEM---TNQDVIKAV----EE----GYR---LPSPMDCP-----------AALYQ-LMLDCWQKERNSRPKFDEIVNML-------
LPPRIPA-------------------------------------------------------------------------------------------------GRPVMIVVEYMENGSLDSFLR---------KH--------------------------------------------------------------------D-GHFTVIQLVGMLRGIASGMKYLSD--M--G---YVHRDLAARNILVNS---NL-VC---------KVSDFGLSRVL----E---D--DPEA-------------AYTTTGGKIPIRWTAPEAIA-----YRK-FSSASDAWSYGIVMWEVMSYGE-RP---------------YWEM---SNQDVILSI----EE----GYR---LPAPMGCP-----------ASLHQ-LMLHCWQKERNHRPKFTDIVSFL-------
-------IHIEKIIGSGDSGEVCYGRLR-------------VPGQRDV---PVAIKALK-A--G-YT-ERQ-RRDFL-SEASIMGQF-DHPNIIRLEGVVT--RGRLAMIVTEYMENGSLDTFLR---------TH--------------------------------------------------------------------D-GQFTIMQLVGMLRGVGAGMRYLSD--L--G---YVHRDLAARNVLVDS---NL-VC---------KVSDFGLSRVL----E---D--DPDA-------------AYTTTGGKIPIRWTAPEAIA-----FRT-FSSASDVWSFGVVMWEVLAYGE-RP---------------YWNM---TNRDVISSV----EE----GYR---LPAPMGCP-----------HALHQ-LMLDCWHKDRAQRPRFSQIVSVL-------
------V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREI---YVAIKTLK-A--G-YS-EKQ-RRDFL-SEASIMGQF-DHPNIIRLEGVVT--KSRPVMIITEFMENGALDSFLR---------QN--------------------------------------------------------------------D-GQFTVIQLVGMLRGIAAGMKYLAE--M--N---YVHRDLAARNILVNS---NL-VC---------KVSDFGLSRYLQ-DDT---S--DPTY--------------TSSLGGKIPVRWTAPEAIA-----YRK-FTSASDVWSYGIVMWEVMSFGE-RP---------------YWDM---SNQDVINAI----EQ----DYR---LPPPMDCP-----------AALHQ-LMLDCWQKDRNSRPRFAEIVNTL-------
------V-KIEQVIGAGEFGEVCSGHLK-------------LPGKREI---FVAIKTLK-S--G-YT-EKQ-RRDFL-SEASIMGQF-DHPNVIHLEGVVT--KSTPVMIITEFMENGSLDSFLR---------QN--------------------------------------------------------------------D-GQFTVIQLVGMLRGIAAGMKYLAD--M--N---YVHRDLAARNILVNS---NL-VC---------KVSDFGLSRFLE-DDT---S--DPTY--------------TSALGGKIPIRWTAPEAIQ-----YRK-FTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM---TNQDVINAI----EQ----DYR---LPPPMDCP-----------SALHQ-LMLDCWQKDRNHRPKFGQIVNTL-------
------V-KIEEVIGAGEFGEVCRGRLK-------------QPGRREV---FVAIKTLK-V--G-YT-ERQ-RRDFL-SEASIMGQF-DHPNIIRLEGVVT--KSRPVMILTEFMENCALDSFLR---------LN--------------------------------------------------------------------D-GQFTVIQLVGMLRGIAAGMKYLSE--M--N---YVHRDLAARNILVNS---NL-VC---------KVSDFGLSRFLE-DDP---S--DPTY--------------TSSLGGKIPIRWTAPEAIA-----YRK-FTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM---SNQDVINAV----EQ----DYR---LPPPMDCP-----------TALHQ-LMLDCWVRDRNLRPKFSQIVNTL-------
------V-KIEEVIGAGEFGEVCRGRLK-------------APGKKES---CVAIKTLK-G--G-YT-ERQ-RREFL-SEASIMGQF-EHPNIIRLEGVVT--NSMPVMILTEFMENGALDSFLR---------LN--------------------------------------------------------------------D-GQFTVIQLVGMLRGIASGMRYLAE--M--S---YVHRDLAARNILVNS---NL-VC---------KVSDFGLSRFLE-ENS---S--DPTY--------------TSSLGGKIPIRWTAPEAIA-----FRK-FTSASDAWSYGIVMWEVMSFGE-RP---------------YWDM---SNQDVINAI----EQ----DYR---LPPPPDCP-----------TSLHQ-LMLDCWQKDRNARPRFPQVVSAL-------
-------IKIEEVIGTGSFGEVRQGRLQ-------------PRGRREQ---TVAIQALW-A--G-GA-ESL-QMTFL-GRAAVLGQF-QHPNILRLEGVVT--KSRPLMVLTEFMELGPLDSFLR---------QR--------------------------------------------------------------------E-GQFSSLQLVAMQRGVAAAMQYLSS--F--A---FVHRSLSAHSVLVNS---HL-VC---------KVARLGHSPQG----------------------------------PSCLLRWAAPEVIA-----HGK-HTTSSDVWSFGILMWEVMSYGE-RP---------------YWDM---SEQEVLNAI----EQ----EFR---LPPPPGCP-----------PGLHL-LMLDTWQKDRARRPHFDQLVA---AF----
------L-RKLKVLGSGVFGTVHKGVWIP------------EGESIKI---PVCIKVIE-D--K-SG-RQS-FQAVT-DHMLAIGSL-DHAHIVRLLGLCP---GSSLQLVTQYLPLGSLLDHVR---------QH--------------------------------------------------------------------R-GALGPQLLLNWGVQIAKGMYYLEE--H--G---MVHRNLAARNVLLKS---PS-QV---------QVADFGVADLL----P---P--DDKQ--------------LLYSEAKTPIKWMALESIH-----FGK-YTHQSDVWSYGVTVWELMTFGA-EP---------------YAGL---RLAEVPDLL----EK----GER---LAQPQICT-----------IDVYM-VMVKCWMIDENIRPTFKELANE--F-----
------L-KRVKVLGSGAFGTVYKGIWVP------------EGETVKI---PVAIKILN-E--T-TG-PKA-NVEFM-DEALIMASM-DHPHLVRLLGVCL---SPTIQLVTQLMPHGCLLEYVH---------EH--------------------------------------------------------------------K-DNIGSQLLLNWCVQIAKGMMYLEE--R--R---LVHRDLAARNVLVKS---PN-HV---------KITDFGLARLL----E---G--DEKE--------------YNADGGKMPIKWMALECIH-----YRK-FTHQSDVWSYGVTIWELMTFGG-KP---------------YDGI---PTREIPDLL----EK----GER---LPQPPICT-----------IDVYM-VMVKCWMIDADSRPKFKELAAE--F-----
-----VI--LGELLGKGNFGEVYKGTLK-----------------DKT---SVAVKTCK-E--D-LP-QEL-KIKFL-QEAKILKQY-DHPNIVKLIGVCT--QRQPVYIIMELVSGGDFLTFLR---------RK--------------------------------------------------------------------K-DELKLKQLVKFSLDAAAGMLYLES--K--N---CIHRDLAARNCLVGE---NN-VL---------KISDFGMSRQE--------D--GGVY--------------SSSGLKQIPIKWTAPEALN-----YGR-YSSESDVWSFGILLWETFSLGV-CP---------------YPGM---TNQQAREQV----ER----GYR---MSAPQHCP-----------EDISK-IMMKCWDYKPENRPKFSELQKEL-------
------L-VLGEQIGRGNFGEVFSGRLR----------------ADNT---LVAVKSCR-E--T-LP-PDL-KAKFL-QEARILKQY-SHPNIVRLIGVCT--QKQPIYIVMELVQGGDFLTFLR---------TE--------------------------------------------------------------------G-ARLRVKTLLQMVGDAAAGMEYLES--K--C---CIHRDLAARNCLVTE---KN-VL---------KISDFGMSREE----A---D--GVYA--------------ASGGLRQVPVKWTAPEALN-----YGR-YSSESDVWSFGILLWETFSLGA-SP---------------YPNL---SNQQTREFV----EK----GGR---LPCPELCP-----------DAVFR-LMEQCWAYEPGQRPSFSTIYQEL-------
------L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVT---KVAVKMLK-S--D-AT-EKD-LSDLI-SEMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLQ---------ARRPPGLEY-----------------------------------------------------CYNPSHNPE-EQLSSKDLVSCAYQVARGMEYLAS--K--K---CIHRDLAARNVLVTE---DN-VM---------KIADFGLARDI----H---H--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRI-YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV---PVEELFKLL----KE----GHR---MDKPSNCT-----------NELYM-MMRDCWHAVPSQRPTFKQLVEDL-------
-------LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAV---TVAVKMLK-D--D-AT-EKD-LSDLV-SEMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLR---------ARRPPGMEY-----------------------------------------------------SYDINRVPE-EQMTFKDLVSCTYQLARGMEYLAS--Q--K---CIHRDLAARNVLVTE---NN-VM---------KIADFGLARDI----N---N--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRV-YTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI---PVEELFKLL----KE----GHR---MDKPANCT-----------NELYM-MMRDCWHAVPSQRPTFKQLVEDL-------
-------LTLGKPLGEGCFGQVVMAEAIGI---------DKDRAAKPV---TVAVKMLK-D--D-AT-DKD-LSDLV-SEMEMMKMIGKHKNIINLLGACT--QGGPLYVLVEYAAKGNLREFLR---------ARRPPGLDY-----------------------------------------------------SFDTCKPPE-EQLTFKDLVSCAYQVARGMEYLAS--Q--K---CIHRDLAARNVLVTE---DN-VM---------KIADFGLARDV----H---N--LDYY--------------KKTTNGRLPVKWMAPEALF-----DRV-YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI---PVEELFKLL----KE----GHR---MDKPANCT-----------HDLYM-IMRECWHAAPSQRPTFKQLVEDL-------
------L-VLGKPLGEGCFGQVVRAEAFGM---------DPARPDQAS---TVAVKMLK-D--N-AS-DKD-LADLV-SEMEVMKLIGRHKNIINLLGVCT--QEGPLYVIVECAAKGNLREFLR---------ARRPPGPDL-----------------------------------------------------SPDGPRSSE-GPLSFPVLVSCAYQVARGMQYLES--R--K---CIHRDLAARNVLVTE---DN-VM---------KIADFGLARGV----H---H--IDYY--------------KKTSNGRLPVKWMAPEALF-----DRV-YTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI---PVEELFSLL----RE----GHR---MDRPPHCP-----------PELYG-LMRECWHAAPSQRPTFKQLVEAL-------
-------LQLIKRLGNGQFGEVWMGTWN-----------------GNT---KVAIKTLK-P--G-TM-SP---ESFL-EEAQIMKKL-KHDKLVQLYAVVS---EEPIYIVTEYMNKGSLLDFLK---------DG-------------------------------------------------------------------EG-RALKLPNLVDMAAQVAAGMAYIER--M--N---YIHRDLRSANILVGN---GL-IC---------KIADFGLARLI--------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR-FTIKSDVWSFGILLTELVTKGR-VP---------------YPGM---NNREVLEQV----ER----GYR---MPCPQDCP-----------ISLHE-LMIHCWKKDPEERPTFEYLQSFL-------
-------LKLEKKLGAGQFGEVWMATYN-----------------KHT---KVAVKTMK-P--G-SM-SV---EAFL-AEANVMKTL-QHDKLVKLHAVVT---KEPIYIITEFMAKGSLLDFLK---------SD-------------------------------------------------------------------EG-SKQPLPKLIDFSAQIAEGMAFIEQ--R--N---YIHRDLRAANILVSA---SL-VC---------KIADFGLARVI--------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----FGS-FTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM---SNPEVIRAL----ER----GYR---MPRPENCP-----------EELYN-IMMRCWKNRPEERPTFEYIQSV--L-----
-------ITLLRELGQGSFGMVYEGNARD-----------IIKGEAET---RVAVKTVN-E--S-AS-LRE-RIEFL-NEASVMKGF-TCHHVVRLLGVVS--KGQPTLVVMELMAHGDLKSYLR---------SLRPEA-----------------------------------------------------------ENNPGR-PPPTLQEMIQMAAEIADGMAYLNA--K--K---FVHRDLAARNCMVAH---DF-TV---------KIGDFGMTRDI----Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGV-FTTSSDMWSFGVVLWEITSLAE-QP---------------YQGL---SNEQVLKFV----MD----GGY---LDQPDNCP-----------ERVTD-LMRMCWQFNPKMRPTFLEIVNLL-------
------I-SIIRELGQGSFGMVYEGLARG-----------LEAGEEST---PVALKTVN-E--L-AS-PRE-CIEFL-KEASVMKAF-KCHHVVRLLGVVS--QGQPTLVIMELMTRGDLKSHLR---------SLRPEA-----------------------------------------------------------ENNPGL-PQPALGEMIQMAGEIADGMAYLAA--N--K---FVHRDLAARNCMVSQ---DF-TV---------KIGDFGMTRDV----Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGI-FTTHSDVWSFGVVLWEIVTLAE-QP---------------YQGL---SNEQVLKFV----MD----GGV---LEELEGCP-----------LQLQE-LMSRCWQPNPRLRPSFTHILD---SI----
-------LTFVQEIGSGQFGLVHLGYWL-----------------NKD---KVAIKTIR-E--G-AM-SE---EDFI-EEAEVMMKL-SHPKLVQLYGVCL--EQAPICLVFEFMEHGCLSDYLR---------TQ--------------------------------------------------------------------R-GLFAAETLLGMCLDVCEGMAYLEE--A--C---VIHRDLAARNCLVGE---NQ-VI---------KVSDFGMTRFV--------L--DDQY--------------TSSTGTKFPVKWASPEVFS-----FSR-YSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR---SNSEVVEDI----ST----GFR---LYKPRLAS-----------THVYQ-IMNHCWKERPEDRPAFSRLLRQL-------
-------LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGE---VVAVKKLQ-H--S-TE--EH-LRDFE-REIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ---------KH--------------------------------------------------------------------K-ERIDHIKLLQYTSQICKGMEYLGT--K--R---YIHRDLATRNILVEN---EN-RV---------KIGDFGLTKVL---PQ---D--KEYY--------------KVKEPGESPIFWYAPESLT-----ESK-FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM---IVFHLIELL----KN----NGR---LPRPDGCP-----------DEIYM-IMTECWNNNVNQRPSFRDLA----LRV---
------L-KYISQLGKGNFGSVELCRYDP------------LGDNTGA---LVAVKQLQ-H--S-GP-DQ--QRDFQ-REIQILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ---------RH--------------------------------------------------------------------R-ARLDASRLLLYSSQICKGMEYLGS--R--R---CVHRDLAARNILVES---EA-HV---------KIADFGLAKLL---PL---D--KDYY--------------VVREPGQSPIFWYAPESLS-----DNI-FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDV-P-ALCRLLELL----EE----GQR---LPAPPACP-----------AEVHE-LMKLCWAPSPQDRPSFSALGP---QL----
-------LKLVERLGAGQFGEVWMGYYN-----------------GHT---KVAVKSLK-Q--G-SM-SP---DAFL-AEANLMKQL-QHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLK---------TP-------------------------------------------------------------------SG-IKLTINKLLDMAAQIAEGMAFIEE--R--N---YIHRDLRAANILVSD---TL-SC---------KIADFGLARLI--------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----YGT-FTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM---TNPEVIQNL----ER----GYR---MVRPDNCP-----------EELYQ-LMRLCWKERPEDRPTFDYLRSV--L-----
------V-TLLRALGHGAFGEVYEGLVIG-----------LPGDSSPL---QVAIKTLP-E--L-CS-PQD-ELDFL-MEALIISKF-RHQNIVRCVGLSL--RATPRLILLELMSGGDMKSFLR---------HSRP--------------------------------------------------------------HLGQP-SPLVMRDLLQLAQDIAQGCHYLEE--N--H---FIHRDIAARNCLLSCAGPSR-VA---------KIGDFGMARDI----Y---R--ASYY--------------RRGDRALLPVKWMPPEAFL-----EGI-FTSKTDSWSFGVLLWEIFSLGY-MP---------------YPGR---TNQEVLDFV----VG----GGR---MDPPRGCP-----------GPVYR-IMTQCWQHEPELRPSFASILERL-------
-------IEVEEVVGRGAFGVVCKAKWR------------------AK---DVAIKQIE-------S-ESE-RKAFI-VELRQLSRV-NHPNIVKLYGACL----NPVCLVMEYAEGGSLYNVLH---------GA-------------------------------------------------------------------EPLPYYTAAHAMSWCLQCSQGVAYLHS--M--QPKALIHRDLKPPNLLLVA---GGTVL---------KICDFGTACDI--------------Q--------------THMTNNKGSAAWMAPEVFE-----GSN-YSEKCDVFSWGIILWEVITR-R-KP---------------FDEIGG-PAFRIMWAV----HN----GTR---PPLIKNLP-----------KPIES-LMTRCWSKDPSQRPSMEEIVKI--M-----
-------LTLGAQIGEGEFGAVLQGEYL------------------GQ---KVAVKNIK-C--D-VT-AQ----AFL-DETAVMTKM-QHENLVRLLGVIL---HQGLYIVMEHVSKGNLVNFLR---------TR-------------------------------------------------------------------GR-ALVNTAQLLQFSLHVAEGMEYLES--K--K---LVHRDLAARNILVSE---DL-VA---------KVSDFGLAKAE--------------R--------------KGLDSSRLPVKWTAPEALK-----HGK-FTSKSDVWSFGVLLWEVFSYGR-AP---------------YPKM---SLKEVSEAV----EK----GYR---MEPPEGCP-----------GPVHV-LMSSCWEAEPARRPPFRKLAEKL-------
-------VHFNEVIGRGHFGCVYHGTLL-------------DNDGKKI---HCAVKSLN-R--I-TD-IGE-VSQFL-TEGIIMKDF-SHPNVLSLLGICL-RSEGSPLVVLPYMKHGDLRNFIR---------NE--------------------------------------------------------------------T-HNPTVKDLIGFGLQVAKGMKYLAS--K--K---FVHRDLAARNCMLDE---KF-TV---------KVADFGLARDM----Y---D--KEYYS------------VHNKTGAKLPVKWMALESLQ-----TQK-FTTKSDVWSFGVLLWELMTRGA-PP---------------YPDV---NTFDITVYL----LQ----GRR---LLQPEYCP-----------DPLYE-VMLKCWHPKAEMRPSFSELVSR--I-----
-------YVLQQKLGSGSFGTVYLVSDK----------------KAKRGEELKVLKEISVG--E-LNPNE---TVQANLEAQLLSKL-DHPAIVKFHASFV--EQDNFCIITEYCEGRDLDDKIQEY----KQAGK-----------------------------------------------------------------------IFPENQIIEWFIQLLLGVDYMHE--R--R---ILHRDLKSKNVFLK----NN-LL---------KIGDFGVSRLL--------MGSCDLA--------------TT---LTGTPHYMSPEALK-----HQG-YDTKSDIWSLACILYEMCC-MN-HA---------------FAGS------NFLSIV----LK----IVE---GDTPSLPERY-P-------KELNA-IMESMLNKNPSLRPSAIEILKIPYL-----
-----IV--LKWELGEGAFGKVFLAECHN-----------LLPEQDKM---LVAVKALK-E--A-SE-SA--RQDFQ-REAELLTML-QHQHIVRFFGVCT--EGRPLLMVFEYMRHGDLNRFLR---------SHGPDAKL------------------------------------------------------LAGGEDVAP-GPLGLGQLLAVASQVAAGMVYLAG--L--H---FVHRDLATRNCLVGQ---GL-VV---------KIGDFGMSRDI----Y---S--TDYY--------------RVGGRTMLPIRWMPPESIL-----YRK-FTTESDVWSFGVVLWEIFTYGK-QP---------------WYQL---SNTEAIDCI----TQ----GRE---LERPRACP-----------PEVYA-IMRGCWQREPQQRHSIKDVHARL-------
------I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKI---LVAVKTLK-D--A-SD-NA--RKDFH-REAELLTNL-QHEHIVKFYGVCV--EGDPLIMVFEYMKHGDLNKFLR---------AHGPDAV--------------------------------------------------------LMAEGNPP-TELTQSQMLHIAQQIAAGMVYLAS--Q--H---FVHRDLATRNCLVGE---NL-LV---------KIGDFGMSRDV----Y---S--TDYY--------------RVGGHTMLPIRWMPPESIM-----YRK-FTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL---SNNEVIECI----TQ----GRV---LQRPRTCP-----------QEVYE-LMLGCWQREPHMRKNIKGIHTL--L-----
------I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKM---LVAVKALK-D--P-TL-AA--RKDFQ-REAELLTNL-QHEHIVKFYGVCG--DGDPLIMVFEYMKHGDLNKFLR---------AHGPDAMIL-----------------------------------------------------VDGQPRQAK-GELGLSQMLHIASQIASGMVYLAS--Q--H---FVHRDLATRNCLVGA---NL-LV---------KIGDFGMSRDV----Y---S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----YRK-FTTESDVWSFGVILWEIFTYGK-QP---------------WFQL---SNTEVIECI----TQ----GRV---LERPRVCP-----------KEVYD-VMLGCWQREPQQRLNIKEIYKIL-------
-------IELGRCIGEGQFGDVHQGIYM-------------SPENPAL---AVAIKTCK-N--C-TS-DSV-REKFL-QEALTMRQF-DHPHIVKLIGVIT---ENPVWIIMELCTLGELRSFLQ---------VR--------------------------------------------------------------------K-YSLDLASLILYAYQLSTALAYLES--K--R---FVHRDIAARNVLVSS---ND-CV---------KLGDFGLSRYM--------E--DSTY--------------YKASKGKLPIKWMAPESIN-----FRR-FTSASDVWMFGVCMWEILMHGV-KP---------------FQGV---KNNDVIGRI----EN----GER---LPMPPNCP-----------PTLYS-LMTKCWAYDPSRRPRFTELKAQL-------
------F-TLCRKLGSGYFGEVFEGLWK-----------------DRV---QVAIKVIS-R--D-NL-LH--QQMLQ-SEIQAMKKL-RHKHILALYAVVS--VGDPVYIITELMAKGSLLELLR---------DS-------------------------------------------------------------------DE-KVLPVSELLDIAWQVAEGMCYLES--Q--N---YIHRDLAARNILVGE---NT-LC---------KVGDFGLARLI-----------KEDV--------------YLSHDHNIPYKWTAPEALS-----RGH-YSTKSDVWSFGILLHEMFSRGQ-VP---------------YPGM---SNHEAFLRV----DA----GYR---MPCPLECP-----------PSVHK-LMLTCWCRDPEQRPCFKALRERL-------
------L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYT---TVAVKMLK-E--N-AS-PSE-LRDLL-SEFNVLKQV-NHPHVIKLYGACS--QDGPLLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSG---------------------------------------------GSRNSSSLDHPDE-RALTMGDLISFAWQISQGMQYLAE--M--K---LVHRDLAARNILVAE---GR-KM---------KISDFGLSRDV----Y---E--EDSY--------------VKRSQGRIPVKWMAIESLF-----DHI-YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI---PPERLFNLL----KT----GHR---MERPDNCS-----------EEMYR-LMLQCWKQEPDKRPVFADISKDL-------
---FTGW----EKVGSGGFGQVYKVRHV----------------HWKT---WLAIKCSPSL--H-VDDRE---RMELLEEAKKMEMA-KFRYILPVYGIC----REPVGLVMEYMETGSLEKLLA---------SE-----------------------------------------------------------------------PLPWDLRFRIIHETAVGMNFLHC--MAPP---LLHLDLKPANILLDA---HY-HV---------KISDFGLAKCNG-----LSHSHDLSM--------------DG---LFGTIAYLPPERIR---EKSRL-FDTKHDVYSFAIVIWGVLT-QK-KP---------------FADE--KNILHIMVKV----VK----GHR---PELPPVCRARPRAC-----SHLIR-LMQRCWQGDPRVRPTFQ--------GNGLN
-------WEIIGELGDGAFGKVYKAQNK----------------ETSV---LAAAKVIDTK--S-EEELE---DYM--VEIDILASC-DHPNIVKLLDAFY--YENNLWILIEFCAGGAVDAVML-------ELER-----------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHD--N--K---IIHRDLKAGNILFTL---DG-DI---------KLADFGVSAKN--------TRTIQRR--------------DS---FIGTPYWMAPEVVMCETSKDRP-YDYKADVWSLGITLIEMAE-IE-PP---------------HHEL---NPMRVLLKI----AK----SEP---PTLAQPSRWS---------SNFKD-FLKKCLEKNVDARWTTSQLLQHPFV-----
------L-RLEVKLGQGCFGEVWMGTWN-----------------GTT---RVAIKTLK-P--G-TM-SP---EAFL-QEAQVMKKL-RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLK---------GE-------------------------------------------------------------------TG-KYLRLPQLVDMAAQIASGMAYVER--M--N---YVHRDLRAANILVGE---NL-VC---------KVADFGLARLI--------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR-FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM---VNREVLDQV----ER----GYR---MPCPPECP-----------ESLHD-LMCQCWRKEPEERPTFEYLQAF--L-----
-----FA--LGRKLGEGYFGEVWEGLWL-----------------GSL---PVAIKVIK-S--A-NM-K---LTDLA-KEIQTLKGL-RHERLIRLHAVCS--GGEPVYIVTELMRKGNLQAFLG---------TP-------------------------------------------------------------------EG-RALRLPPLLGFACQVAEGMSYLEE--Q--R---VVHRDLAARNVLVDD---GL-AC---------KVADFGLARLL--------K--DDIY--------------SPSSSSKIPVKWTAPEAAN-----YRV-FSQKSDVWSFGVLLHEVFTYGQ-CP---------------YEGM---TNHETLQQI----MR----GYR---LPRPAACP-----------AEVYV-LMLECWRSSPEERPSFATLREKL-------
-------WEIVGELGDGAFGKVYKAKNK----------------ETGA---LAAAKVIETK--S-EEELE---DYI--VEIEILATC-DHPYIVKLLGAYY--HDGKLWIMIEFCPGGAVDAIML-------ELDR-----------------------------------------------------------------------GLTEPQIQVVCRQMLEALNFLHS--K--R---IIHRDLKAGNVLMTL---EG-DI---------RLADFGVSAKN--------LKTLQKR--------------DS---FIGTPYWMAPEVVMCETMKDTP-YDYKADIWSLGITLIEMAQ-IE-PP---------------HHEL---NPMRVLLKI----AK----SDP---PTLLTPSKWS---------VEFRD-FLKIALDKNPETRPSAAQLLEHPFV-----
-------FTKLEKIGKGSFGEVFKGIDN----------------RTQK---VVAIKIIDLE--E-AEDEI---EDIQ-QEITVLSQC-DSPYVTKYYGSYL--KDTKLWIIMEYLGGGSALDLLE---------PG-----------------------------------------------------------------------PLDETQIATILREILKGLDYLHS--E--K---KIHRDIKAANVLLSE---HG-EV---------KLADFGVAGQL--------TDTQIKR--------------NT---FVGTPFWMAPEVIK-----QSA-YDSKADIWSLGITAIELAR-GE-PP---------------HSEL---HPMKVLFLI----PK----NNP---PTLEGNYS-----------KPLKE-FVEACLNKEPSFRPTAKELLKHKFI-----
------F-DVLEKLGEGSYGSVFKAIHK----------------ESGQ---VVAIKQVPVE--S-DLQEI-------IKEISIMQQC-DSPYVVKYYGSYF--KNTDLWIVMEYCGAGSVSDIIR-------LRNK-----------------------------------------------------------------------TLIEDEIATILKSTLKGLEYLHF--M--R---KIHRDIKAGNILLNT---EG-HA---------KLADFGVAGQL--------TDTMAKR--------------NT---VIGTPFWMAPEVIQ-----EIG-YNCVADIWSLGITSIEMAE-GK-PP---------------YADI---HPMRAIFMI----PT----NPP---PTFRKPELWS---------DDFTD-FVKKCLVKNPEQRATATQLLQHPFI-----
-------YELQEVIGSGATAVVQAALCK----------------PRQE---RVAIKRINLE--K-CQTSM---DE-LLKEIQAMSQC-SHPNVVTYYTSFV--VKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNG-----------------------------------------------------------------------VLEEAIIATILKEVLEGLDYLHR--N--G---QIHRDLKAGNILLGE---DG-SV---------QIADFGVSAFLAT---GGDVTRNKVR--------------KT---FVGTPCWMAPEVME----QVRG-YDFKADMWSFGITAIELAT-GA-AP---------------YHKY---PPMKVLMLT----LQ----NDP---PTLETGVEDKE--MMKKYGKSFRK-LLSLCLQKDPSKRPTAAELLKCKFF-----
------F-DVLEKLGEGSYGSVYKAIHK----------------ETGQ---IVAIKQVPVE--S-DLQEI-------IKEISIMQQC-DSPHVVKYYGSYF--KNTDLWIVMEYCGAGSVSDIIR-------LRNK-----------------------------------------------------------------------TLTEDEIATILQSTLKGLEYLHF--M--R---KIHRDIKAGNILLNT---EG-HA---------KLADFGVAGQL--------TDTMAKR--------------NT---VIGTPFWMAPEVIQ-----EIG-YNCVADIWSLGITAIEMAE-GK-PP---------------YADI---HPMRAIFMI----PT----NPP---PTFRKPELWS---------DNFTD-FVKQCLVKSPEQRATATQLLQHPFV-----
----TLE---DKELGSGNFGTVKKGYYQ--------------MKKVVK---TVAVKILK-N--E-AN-DPALKDELL-AEANVMQQL-DNPYIVRMIGICE---AESWMLVMEMAELGPLNKYLQ---------QN----------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEE--S--N---FVHRDLAARNVLLVT---QH-YA---------KISDFGLSKAL----R---A--DENY-------------YKAQTHGKWPVKWYAPECIN-----YYK-FSSKSDVWSFGVLMWEAFSYGQ-KP---------------YRGM---KGSEVTAML----EK----GER---MGCPAGCP-----------REMYD-LMNLCWTYDVENRPGFAAVE----LRL---
-------LTFMRELGSGLFGVVRLGKWR-----------------AQY---KVAIKAIR-E--G-AM-CE---EDFI-EEAKVMMKL-THPKLVQLYGVCT--QQKPIYIVTEFMERGCLLNFLR---------QR--------------------------------------------------------------------Q-GHFSRDVLLSMCQDVCEGMEYLER--N--S---FIHRDLAARNCLVSE---AG-VV---------KVSDFGMARYV--------L--DDQY--------------TSSSGAKFPVKWCPPEVFN-----YSR-FSSKSDVWSFGVLMWEVFTEGR-MP---------------FEKY---TNYEVVTMV----TR----GHR---LYQPKLAS-----------NYVYE-VMLRCWQEKPEGRPSFEDLLRT--I-----
-------IKFQDVIGEGNFGQVLKARIK--------------KDGLRM---DAAIKRMK-E--Y-AS-KDD-HRDFA-GELEVLCKLGHHPNIINLLGACE--HRGYLYLAIEYAPHGNLLDFLR---------KSRVLETDP-----------------------------------------------------AFAIANSTA-STLSSQQLLHFAADVARGMDYLSQ--K--Q---FIHRDLAARNILVGE---NY-VA---------KIADFGLSRGQ------------EVY--------------VKKTMGRLPVRWMAIESLN-----YSV-YTTNSDVWSYGVLLWEIVSLGG-TP---------------YCGM---TCAELYEKL----PQ----GYR---LEKPLNCD-----------DEVYD-LMRQCWREKPYERPSFAQILV---SL----
-------ITFEDLIGEGNFGQVIRAMIK--------------KDGLKM---NAAIKMLK-E--Y-AS-END-HRDFA-GELEVLCKLGHHPNIINLLGACK--NRGYLYIAIEYAPYGNLLDFLR---------KSRVLETDP-----------------------------------------------------AFAREHGTA-STLSSRQLLRFASDAANGMQYLSE--K--Q---FIHRDLAARNVLVGE---NL-AS---------KIADFGLSRGE------------EVY--------------VKKTMGRLPVRWMAIESLN-----YSV-YTTKSDVWSFGVLLWEIVSLGG-TP---------------YCGM---TCAELYEKL----PQ----GYR---MEQPRNCD-----------DEVYE-LMRQCWRDRPYERPPFAQIALQ--L-----
------L-RLLEKLGDGSFGVVRRGEWD-------------APSGKTV---SVAVKCLK-PDVL-SQ-PEA-MDDFI-REVNAMHSL-DHRNLIRLYGVVL---TPPMKMVTELAPLGSLLDRLR---------KH--------------------------------------------------------------------Q-GHFLLGTLSRYAVQVAEGMGYLES--K--R---FIHRDLAARNLLLAT---RD-LV---------KIGDFGLMRAL---PQ---N--DDHY--------------VMQEHRKVPFAWCAPESLK-----TRT-FSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL---NGSQILHKI---DKE----GER---LPRPEDCP-----------QDIYN-VMVQCWAHKPEDRPTFVALRDF--L-----
-------IEFHEIIGSGSFGKVYKGRCR------------------NK---IVAIKRYR-ANTY-CS-KSD-VDMFC-REVSILCQL-NHPCVIQFVGACL-NDPSQFAIVTQYISGGSLFSLLH---------EQ--------------------------------------------------------------------K-RILDLQSKLIIAVDVAKGMEYLHNLTQ--P---IIHRDLNSHNILLYE---DG-HA---------VVADFGESRFL----Q---S--LD-E--------------DNMTKQPGNLRWMAPEVFT-----QCTRYTIKADVFSYALCLWEILT-GE-IP---------------FAHL---KPAAAAADM---AYH----HIR---PPIGYSIP-----------KPISS-LLIRGWNACPEGRPEFSEVVMKL-------
------L-AFIKEIGSGQFGVVHLGEWR-----------------SHI---QVAIKAIN-E--G-SM-SE---EDFI-EEAKVMMKL-SHSKLVQLYGVCI--QRKPLYIVTEFMENGCLLNYLR---------EN--------------------------------------------------------------------K-GKLRKEMLLSVCQDICEGMEYLER--N--G---YIHRDLAARNCLVSS---TC-IV---------KISDFGMTRYV--------L--DDEY--------------VSSFGAKFPIKWSPPEVFL-----FNK-YSSKSDVWSFGVLMWEVFTEGK-MP---------------FENK---SNLQVVEAI----SE----GFR---LYRPHLAP-----------MSIYE-VMYSCWHEKPEGRPTFAELLR---AV----
-----FS--RKDLIGHGAFAVVFKGRHR----------------EKHD--LEVAVKCINKK--N-LAKSQ---T-LLGKEIKILKEL-KHENIVALYDFQE--MANSVYLVMEYCNGGDLADYLH--------AMR-----------------------------------------------------------------------TLSEDTIRLFLQQIAGAMRLLHS--K--G---IIHRDLKPQNILLSN---PA-GRRANPNSIRVKIADFGFARY---------LQSNMMA--------------AT---LCGSPMYMAPEVIM-----SQH-YDGKADLWSIGTIVYQCLT-GK-AP---------------FQAS---SPQDLRLFY----EK----NKT---LVPTIPRETS---------APLRQ-LLLALLQRNHKDRMDFDEFFHHPFL-----
------L-RLEVKLGQGCFGEVWMGTWN-----------------GTT---KVAIKTLK-P--G-TM-MP---EAFL-QEAQIMKKL-RHDKLVPLYAVVS---EEPIYIVTEFMSKGSLLDFLK---------EG-------------------------------------------------------------------DG-KYLKLPQLVDMAAQIADGMAYIER--M--N---YIHRDLRAANILVGE---NL-VC---------KIADFGLARLI--------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR-FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM---VNREVLEQV----ER----GYR---MPCPQGCP-----------ESLHE-LMNLCWKKDPDERPTFEYIQSFL-------
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