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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FGR 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
CAMK CAMK2A 13
CAMK CAMK2D 14
Other CAMKK1 128
Other CAMKK2 165
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
CMGC CDK6 13
CMGC CDKL2 4
CAMK CHEK1 9
CAMK DAPK1 13
CAMK DAPK2 23
CMGC DYRK1B 111
CMGC DYRK2 222
TK FYN 271
AGC GRK1 190
AGC GRK4 187
AGC GRK6 186
AGC GRK7 191
CMGC GSK3A 119
CMGC HIPK1 190
CMGC HIPK4 -1
CMGC ICK 4
TK INSR 1023
TKL IRAK4 186
TK ITK 363
TK JAK3 822
TK KIT 589
TKL LRRK2 1886
CMGC MAK 4
TKL MAP3K11 117
TKL MAP3K12 125
TKL MAP3K13 168
TKL MAP3K9 144
CAMK MAPKAPK2 64
TK MET 1078
STE MST4 24
TK MUSK 575
TK NTRK2 538
STE PAK4 321
CAMK PHKG1 20
CAMK PHKG2 24
AGC PKN2 657
Other PLK2 82
AGC PRKCQ 380
TK PTK6 191
TK RET 724
Other SBK1 53
STE SLK 34
CAMK STK17A 61
CAMK STK17B 33
STE STK24 24
STE STK25 20
TK TNK1 116
TK TNK2 150
-----ITLERRLGTGCFGDVWLGTWN------GST-KVAVKTL---K-P--G-TM-SP-----K-AFL-E-------------------------EAQVMKLL--R------HDK-----LVQLYAVVS--------EEPIY--IVTEFMCHG--SLLDFLK-----NP--------------------------------------------------------------------------EGQDL---RLPQLVDMAAQVAEGMAYMER--M---N---YIHRDLRAANILVG--E--------RLAC--------KIADFGLARLI----K--DDEY--NPCQGSKFPIKWTAPEAAL------FGR--FTIKSDVWSFGILLTELITKGRIP-------------YPGM----NKREV-LEQV-EQGYHMPCPPGCP-----------------------------------------------------------------------------ASLYEAMEQTWRLDPEERPT-----FE-YLQSFL--------------
-----FEIGRPLGKGKFGNVYLAREK-----QSKF-ILALKVL---FKA--QLEKAGV-----E-HQLRR-------------------------EVEIQSHL--R------HPN-----ILRLYGYFH--D-----ATRVY--LILEYAPLG--TVYRELQ----KLS-----------------------------------------------------------------------------KF---DEQRTATYITELANALSYCHS--K---R---VIHRDIKPENLLLG--S--------AGEL--------KIADFGWSV------HAPSSRR--TT---LCGTLDYLPPEMIE------GRM--HDEKVDLWSLGVLCYEFLV-GKPP-------------FEAN-------TY-QETY-KRISRVEFTFPDFVT---------------------------------------------------------------------------EGARDLISRLLKHNPSQRPM-----LR-EVLEHPWI------------
-----FEIGRPLGKGKFGNVYLAREK-----KSHF-IVALKVL---FKS--Q-IEKEG-----V-EHQLR------------------------REIEIQAHL--H------HPN-----ILRLYNYFY--D-----RRRIY--LILEYAPRG--ELYKELQ----KSC-----------------------------------------------------------------------------TF---DEQRTATIMEELADALMYCHG--K---K---VIHRDIKPENLLLG--L--------KGEL--------KIADFGWSV------HAPSLRR--KT---MCGTLDYLPPEMIE------GRM--HNEKVDLWCIGVLCYELLV-GNPP-------------FESA-------SH-NETY-RRIVKVDLKFPASVP---------------------------------------------------------------------------MGAQDLISKLLRHNPSERLP-----LA-QVSAHPWV------------
-----FEIGRPLGKGKFGNVYLARLK-----ESHF-IVALKVL---FKS--Q-IEKEG-----L-EHQLR------------------------REIEIQAHL--Q------HPN-----ILRLYNYFH--D-----ARRVY--LILEYAPRG--ELYKELQ----KSE-----------------------------------------------------------------------------KL---DEQRTATIIEELADALTYCHD--K---K---VIHRDIKPENLLLG--F--------RGEV--------KIADFGWSV------HTPSLRR--KT---MCGTLDYLPPEMIE------GRT--YDEKVDLWCIGVLCYELLV-GYPP-------------FESA-------SH-SETY-RRILKVDVRFPLSMP---------------------------------------------------------------------------LGARDLISRLLRYQPLERLP-----LA-QILKHPWV------------
-----YQLFEELGKGAFSVVRRCVKV-----LAGQ-EYAAKII---NTK--K-LSARD-----H-QKLER-------------------------EARICRLL--K------HPN-----IVRLHDSIS--E-----EGHHY--LIFDLVTGG--ELFEDIV----ARE-----------------------------------------------------------------------------YY---SEADASHCIQQILEAVLHCHQ--M---G---VVHRDLKPENLLLA--S--------KLKGA-----AVKLADFGLAIEV----EGEQQAW--FG---FAGTPGYLSPEVLR------KDP--YGKPVDLWACGVILYILLV-GYPP-------------FWDE-------DQ-HRLY-QQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKDLINKMLTINPSKRIT-----AA-EALKHPWI------------
-----YQLFEELGKGAFSVVRRCMKI-----PTGQ-EYAAKII---NTK--K-LSARD-----H-QKLER-------------------------EARICRLL--K------HPN-----IVRLHDSIS--E-----EGFHY--LVFDLVTGG--ELFEDIV----ARE-----------------------------------------------------------------------------YY---SEADASHCIQQILESVNHCHL--N---G---IVHRDLKPENLLLA--S--------KSKGA-----AVKLADFGLAIEV----QGDQQAW--FG---FAGTPGYLSPEVLR------KDP--YGKPVDMWACGVILYILLV-GYPP-------------FWDE-------DQ-HRLY-QQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKDLINKMLTINPAKRIT-----AS-EALKHPWI------------
-----YKLQSEIGKGAYGVVRLAYNE-----SEDR-HYAMKVL---SKK--K-LLKQY-----G-FPR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKL--D------HVN-----VVKLIEVLD--DP---AEDNLY--LVFDLLRKG--PVMEVPC-----DK-----------------------------------------------------------------------------PF---SEEQARLYLRDVILGLEYLHC--Q---K---IVHRDIKPSNLLLG--D--------DGHV--------KIADFGVSNQF----EGNDAQL--SS---TAGTPAFMAPEAISD---SGQSF--SGKALDVWATGVTLYCFVY-GKCP-------------FIDD-------FI-LALH-RKIKNEPVVFPEEPEIS-------------------------------------------------------------------------EELKDLILKMLDKNPETRIG-----VP-DIKLHPWV------------
-----YTLKDEIGKGSYGVVKLAYNE-----NDNT-YYAMKVL---SKK--K-LIRQA-----G-FPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL--D------HPN-----VVKLVEVLD--DP---NEDHLY--MVFELVNQG--PVMEVPT-----LK-----------------------------------------------------------------------------PL---SEDQARFYFQDLIKGIEYLHY--Q---K---IIHRDIKPSNLLVG--E--------DGHI--------KIADFGVSNEF----KGSDALL--SN---TVGTPAFMAPESLS-----ETRKIFSGKALDVWAMGVTLYCFVF-GQCP-------------FMDE-------RI-MCLH-SKIKSQALEFPDQPDIA-------------------------------------------------------------------------EDLKDLITRMLDKNPESRIV-----VP-EIKLHPWV------------
-----YTKIEKIGEGTYGVVYKGRHK-----TTGQ-VVAMKKI---RLE--S-EEEGV-----P-STAIR-------------------------EISLLKEL--R------HPN-----IVSLQDVLM--Q-----DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-----------------------------------------------------------------------------YM---DSSLVKSYLYQILQGIVFCHS--R---R---VLHRDLKPQNLLID--D--------KGTI--------KLADFGLARAF----GIPIRVY--TH---EVVTLWYRSPEVLL-----GSAR--YSTPVDIWSIGTIFAELAT-KKPL-------------FHGD----SEIDQ-LFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------------------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GK-MALNHPYF------------
-----FQKVEKIGEGTYGVVYKARNK-----LTGE-VVALKKI---RLD--T-ETEGV-----P-STAIR-------------------------EISLLKEL--N------HPN-----IVKLLDVIH--T-----ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------------------------------------------------------------------------GI---PLPLIKSYLFQLLQGLAFCHS--H---R---VLHRDLKPQNLLIN--T--------EGAI--------KLADFGLARAF----GVPVRTY--TH---EVVTLWYRAPEILL-----GCKY--YSTAVDIWSLGCIFAEMVT-RRAL-------------FPGD----SEIDQ-LFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AK-AALAHPFF------------
-----YEKLEKIGEGTYGTVFKAKNR-----ETHE-IVALKRV---RLD--D-DDEGV-----P-SSALR-------------------------EICLLKEL--K------HKN-----IVRLHDVLH--S-----DKKLT--LVFEFCDQ---DLKKYFD---SCNG-----------------------------------------------------------------------------DL---DPEIVKSFLFQLLKGLGFCHS--R---N---VLHRDLKPQNLLIN--R--------NGEL--------KLADFGLARAF----GIPVRCY--SA---EVVTLWYRPPDVLF-----GAKL--YSTSIDMWSAGCIFAELANAGRPL-------------FPGN----DVDDQ-LKRI-FRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------------------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AE-EALQHPYF------------
-----YECVAEIGEGAYGKVFKARDL-----KNGGRFVALKRV---RVQ--T-GEEGM-----P-LSTIR-------------------------EVAVLRHL--ET---FEHPN-----VVRLFDVCT--VSRTDRETKLT--LVFEHVDQ---DLTTYLDK--VPEP-----------------------------------------------------------------------------GV---PTETIKDMMFQLLRGLDFLHS--H---R---VVHRDLKPQNILVT--S--------SGQI--------KLADFGLARI-----YSFQMAL--TS---VVVTLWYRAPEVLL------QSS--YATPVDLWSVGCIFAEMFR-RKPL-------------FRGS----SDVDQ-LGKI-LDVIGLPGEEDWPRDVALPRQAFHSKSAQ---------------------------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS-----AY-SALSHPYF------------
-----YENLGLVGEGSYGMVMKCRNK-----DTGR-IVAIKKF---LES--D-DDKMV-----K-KIAMR-------------------------EIKLLKQL--R------HEN-----LVNLLEVCK--K-----KKRWY--LVFEFVDHT--ILDDLEL----FPN-----------------------------------------------------------------------------GL---DYQVVQKYLFQIINGIGFCHS--H---N---IIHRDIKPENILVS--Q--------SGVV--------KLCDFGFARTL----AAPGEVY--TD---YVATRWYRAPELLV-----GDVK--YGKAVDVWAIGCLVTEMFM-GEPL-------------FPGD----SDIDQ-LYHI-MMCLGNLIPRHQELFNKNPVFAGVRLPEIKE-----------------------------------------------REPLERRYPKLSEVVIDLAKKCLHIDPDKRPF-----CA-ELLHHDFF------------
----W-DLVQTLGEGAYGEVQLAVNR-----VTEE-AVAVKIV---DMK--R-AVDCP-----E-NI-KK-------------------------EICINKML--N------HEN-----VVKFYGHRR--E-----GNIQY--LFLEYCSGG--ELFDRIE----PDI-----------------------------------------------------------------------------GM---PEPDAQRFFHQLMAGVVYLHG--I---G---ITHRDIKPENLLLD--E--------RDNL--------KISDFGLATVFR--YNNRERLL--NK---MCGTLPYVAPELLK-----RREF--HAEPVDVWSCGIVLTAMLA-GELP-------------WDQP------SDS-CQEY-SDWKEKKTYLNPWKKI--D-----------------------------------------------------------------------SAPLALLHKILVENPSARIT-----IP-DIKKDRW-Y-----------
-----YDTGEELGSGQFAVVKKCREK-----STGL-QYAAKFI---KKR--R-TKSSR-----R-GVSREDI---------------------EREVSILKEI--Q------HPN-----VITLHEVYE--N-----KTDVI--LILELVAGG--ELFDFLA----EKE-----------------------------------------------------------------------------SL---TEEEATEFLKQILNGVYYLHS--L---Q---IAHFDLKPENIMLL--D--------RNVPKP----RIKIIDFGLAHK-----IDFGNEF--KN---IFGTPEFVAPEIVN------YEP--LGLEADMWSIGVITYILLS-GASP-------------FLGD-------TK-QETL-ANVSAVNYEFEDEYFSNTS-----------------------------------------------------------------------ALAKDFIRRLLVKDPKKRMT-----IQ-DSLQHPWI------------
-----YDIGEELGSGQFAIVKKCREK-----STGL-EYAAKFI---KKR--Q-SRASR-----R-GVSREEI---------------------EREVSILRQV--L------HHN-----VITLHDVYE--N-----RTDVV--LILELVSGG--ELFDFLA----QKE-----------------------------------------------------------------------------SL---SEEEATSFIKQILDGVNYLHT--K---K---IAHFDLKPENIMLL--D--------KNIPIP----HIKLIDFGLAHE-----IEDGVEF--KN---IFGTPEFVAPEIVN------YEP--LGLEADMWSIGVITYILLS-GASP-------------FLGD-------TK-QETL-ANITAVSYDFDEEFFSQTS-----------------------------------------------------------------------ELAKDFIRKLLVKETRKRLT-----IQ-EALRHPWI------------
-----YEIDSLIGKGSFGQVVKAYDH-----QTQE-LVAIKII---KNK--K-AFLNQ-----A-QI----------------------------ELRLLELM-NQ------HDTEMKYYIVHLKRHFM--F-----RNHLC--LVFELLSY---NLYDLLR-----NT-----------------------------------------------------------------------------HFRGVSLNLTRKLAQQLCTALLFLATPEL---S---IIHCDLKPENILLCNPK--------RSAI--------KIVDFGSSCQ-------LGQRI--YQ---YIQSRFYRSPEVLL------GTP--YDLAIDMWSLGCILVEMHT-GEPL-------------FSGS----NEVDQ-MNRI-VEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGT--------------RRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARIS-----PL-GALQHGFF------------
-----YEVLKVIGKGSFGQVVKAYDH-----KVHQ-HVALKMV---RNE--K-RFHRQ-----A-AE----------------------------EIRILEHL--RKQDKDNTMN-----VIHMLENFT--F-----RNHIC--MTFELLSM---NLYELIKK--NKFQ-----------------------------------------------------------------------------GF---SLPLVRKFAHSILQCLDALHK--N---R---IIHCDLKPENILLK--Q--------QGRSG------IKVIDFGSSC-------YEHQRV--YT---YIQSRFYRAPEVIL------GAR--YGMPIDMWSLGCILAELLT-GYPL-------------LPGE----DEGDQ-LACM-IELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNG-------------------GRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMT-----PG-QALRHPWL------------
-----LQLIKRLGNGQFGEVWMGTWN------GNT-KVAIKTL---K-P--G-TM-SP-----E-SFL-E-------------------------EAQIMKKL--K------HDK-----LVQLYAVVS--------EEPIY--IVTEYMNKG--SLLDFLK-----DG--------------------------------------------------------------------------EGRAL---KLPNLVDMAAQVAAGMAYIER--M---N---YIHRDLRSANILVG--N--------GLIC--------KIADFGLARLI----E--DNEY--TARQGAKFPIKWTAPEAAL------YGR--FTIKSDVWSFGILLTELVTKGRVP-------------YPGM----NNREV-LEQV-ERGYRMPCPQDCP-----------------------------------------------------------------------------ISLHELMIHCWKKDPEERPT-----FE-YLQSFL--------------
-FLDF----RVLGKGGFGEVSACQMK-----ATGK-LYACKKL---NKK--R-LKKRK-----G-YQGAM------------------------VEKKILMKV--H------SRF-----IVSLAYAFE--T-----KADLC--LVMTIMNGG--DIRYHIYNVNEENP-----------------------------------------------------------------------------GF---PEPRALFYTAQIICGLEHLHQ--R---R---IVYRDLKPENVLLD--N--------DGNV--------RISDLGLAVEL----LDGQSKT--KG---YAGTPGFMAPELLQ------GEE--YDFSVDYFALGVTLYEMIA-ARGP-------------FRAR---GEKVEN-KELK-HRIISEPVKYPDKFS---------------------------------------------------------------------------QASKDFCEALLEKDPEKRLG-----FR-D-------ETCDKLRAHPLF
---FR--HYRVLGKGGFGEVCACQVR-----ATGK-MYACKKL---QKK--R-IKKRK-----G-EAMAL------------------------NEKRILEKV--Q------SRF-----VVSLAYAYE--T-----KDALC--LVLTIMNGG--DLKFHIYN--LGNP-----------------------------------------------------------------------------GF---DEQRAVFYAAELCCGLEDLQR--E---R---IVYRDLKPENILLD--D--------RGHI--------RISDLGLATE-----IPEGQRV--RG---RVGTVGYMAPEVVN------NEK--YTFSPDWWGLGCLIYEMIQ-GHSP-------------FKKY----KEKVK-WEEV-DQRIKNDTEEYSE---KFS-----------------------------------------------------------------------EDAKSICRMLLTKNPSKRLGCRGEGAA-GVKQHPV-F-----------
----F-RQYRVLGKGGFGEVCACQVR-----ATGK-MYACKKL---EKK--R-IKKRK-----G-EAMAL------------------------NEKQILEKV--N------SRF-----VVSLAYAYE--T-----KDALC--LVLTLMNGG--DLKFHIYH--MGQA-----------------------------------------------------------------------------GF---PEARAVFYAAEICCGLEDLHR--E---R---IVYRDLKPENILLD--D--------HGHI--------RISDLGLAVH-----VPEGQTI--KG---RVGTVGYMAPEVVK------NER--YTFSPDWWALGCLLYEMIA-GQSP-------------FQQR----KKKIK-REEV-ERLVK-EVPEEYSER--FS-----------------------------------------------------------------------PQARSLCSQLLCKDPAERLGCRGGSAR-EVKEHPLF------------
----F-TEFRVLGKGGFGEVCAVQVK-----NTGK-MYACKKL---DKK--R-LKKKG-----G-EKMAL------------------------LEKEILEKV--S------SPF-----IVSLAYAFE--S-----KTHLC--LVMSLMNGG--DLKFHIYN--VGTR-----------------------------------------------------------------------------GL---DMSRVIFYSAQIACGMLHLHE--L---G---IVYRDMKPENVLLD--D--------LGNC--------RLSDLGLAVE-----MKGGKPI--TQ---RAGTNGYMAPEILM-----EKVS--YSYPVDWFAMGCSIYEMVA-GRTP-------------FKDY---KEKVSK-EDLK-QRTLQDEVKFQHDNF---T-----------------------------------------------------------------------EEAKDICRLFLAKKPEQRLG-----SR-E-------KSDDPR------
-----YTDIKVIGNGSFGVVYQARLA-----ETRE-LVAIKKV---LQD--K-RFKNR-------------------------------------ELQIMRKL--D------HCN-----IVRLRYFFY--SSG-EKKDELYLNLVLEYVPETVYRVARHFT---KAKL-----------------------------------------------------------------------------TI---PILYVKVYMYQLFRSLAYIHS--Q---G---VCHRDIKPQNLLVD-PD--------TAVL--------KLCDFGSAKQ-----LVRGEPN--VS---YICSRYYRAPELIF-----GATD--YTSSIDVWSAGCVLAELLL-GQPI-------------FPGD----SGVDQ-LVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-----PL-EACAHSFF------------
-----YEVLEFLGRGTFGQVAKCWKR-----STKE-IVAIKIL---KNH--P-SYARQ-----G-QI----------------------------EVSILSRL--S------SENADEYNFVRSYECFQ--H-----KNHTC--LVFEMLEQ---NLYDFLKQ--NKFS-----------------------------------------------------------------------------PL---PLKYIRPILQQVATALMKLKS--L---G---LIHADLKPENIMLV--D--------PVRQPY----RVKVIDFGSAS------HVSKAVC--ST---YLQSRYYRAPEIIL------GLP--FCEAIDMWSLGCVIAELFL-GWPL-------------YPGA----SEYDQ-IRYI-SQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKE------ARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRIT-----PL-KTLNHQFV------------
-----YDIIEVLGKGTFGEVAKGWRR-----STGE-MVAIKIL---KND--A-YRNRI-----I-KN----------------------------ELKLLHCM--RGL-DPEEAH-----VIRFLEFFH--D-----ALKFY--LVFELLEQ---NLFEFQK-----EN-----------------------------------------------------------------------------NFAPLPARHIRTVTLQVLTALARLKE--L---A---IIHADLKPENIMLV--D--------QTRCPF----RVKVIDFGSASIF----SEVRYVK--EP---YIQSRFYRAPEILL------GLP--FCEKVDVWSLGCVMAELHL-GWPL-------------YPGN----NEYDQ-VRYI-CETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERIS-----PS-AALRHPFV------------
-----YTTIRQLGDGTYGSVLLGRSI-----ESGE-LIAIKKM---KRK--F-YSWEE-----C--MNLR-------------------------EVKSLKKL--N------HAN-----VVKLKEVIR--E-----NDHLY--FIFEYMKE---NLYQLIK---ERNK-----------------------------------------------------------------------------LF---PESAIRNIMYQILQGLAFIHK--H---G---FFHRDLKPENLLCM--G--------PELV--------KIADFGLARE-----IRSKPPY--TD---YVSTRWYRAPEVLL-----RSTN--YSSPIDVWAVGCIMAEVYT-LRPL-------------FPGA----SEIDT-IFKI-CQVLGTPKKTDWPEGYQLSSAMNFRWPQCV------------------------------------------------PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPT-----AS-QALRYPYF------------
-----ITLLRELGQGSFGMVYEGNARDIIKGEAET-RVAVKTV---N-E--S-AS-LRE---RI-EFL-N-------------------------EASVMKGF--T------CHH-----VVRLLGVVS--K-----GQPTL--VVMELMAHG--DLKSYLR-----SLRPEA------------------------------------------------------------------ENNPGRPPP---TLQEMIQMAAEIADGMAYLNA--K---K---FVHRDLAARNCMVA--H--------DFTV--------KIGDFGMTRDI--Y-E--TDYY--RKGGKGLLPVRWMAPESLK------DGV--FTTSSDMWSFGVVLWEITSLAEQP-------------YQGL----SNEQV-LKFV-MDGGYLDQPDNCP-----------------------------------------------------------------------------ERVTDLMRMCWQFNPKMRPT-----FL-EIVNLL--------------
--VGG----NKMGEGGFGVVYKGYVN-----NTT---VAVKKL---AAM--V-DITTE-----ELKQQFD------------------------QEIKVMAKC--Q------HEN-----LVELLGFSS--D-----GDDLC--LVYVYMPNG--SLLDRLSC-LDGTP-----------------------------------------------------------------------------PL---SWHMRCKIAQGAANGINFLHE--N---H---HIHRDIKSANILLD--E--------AFTA--------KISDFGLARASE--KFAQTVMT--SR---IVGTTAYMAPEALR-------GE--ITPKSDIYSFGVVLLEIIT-GLPA-------------VDEH----REPQL-LLDI-KEEIEDEEKTIEDYIDKKMNDAD---------------------------------------------------------------STSVEAMYSVASQCLHEKKNKRPD-----IK-KVQQ----LLQ---------
-----LTFVQEIGSGQFGLVHLGYWL------NKD-KVAIKTI---R-E--G-AM-SE-----E-DFI-E-------------------------EAEVMMKL--S------HPK-----LVQLYGVCL--E-----QAPIC--LVFEFMEHG--CLSDYLR-----TQ---------------------------------------------------------------------------RGLF---AAETLLGMCLDVCEGMAYLEE--A---C---VIHRDLAARNCLVG--E--------NQVI--------KVSDFGMTRFV----L--DDQY--TSSTGTKFPVKWASPEVFS------FSR--YSSKSDVWSFGVLMWEVFSEGKIP-------------YENR----SNSEV-VEDI-STGFRLYKPRLAS-----------------------------------------------------------------------------THVYQIMNHCWKERPEDRPA-----FS-RLLRQL--------------
----L-KYISQLGKGNFGSVELCRYDP-LGDNTGA-LVAVKQL---Q-H--S-GP-DQ----QR-DFQ-R-------------------------EIQILKAL--H------SDF-----IVKYRGVSYGPG-----RQSLR--LVMEYLPSG--CLRDFLQ-----RH---------------------------------------------------------------------------RARL---DASRLLLYSSQICKGMEYLGS--R---R---CVHRDLAARNILVE--S--------EAHV--------KIADFGLAKLL-PL-D--KDYY--VVREPGQSPIFWYAPESLS------DNI--FSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDV-P--ALCRL-LELL-EEGQRLPAPPACP-----------------------------------------------------------------------------AEVHELMKLCWAPSPQDRPS-----FS-ALGP---QL-----------
-----LSFGKTLGAGAFGKVVEATAYGLIKSDAAM-TVAVKML---K-P--S-AH-LTE---RE-ALM-S-------------------------ELKVLSYLG-N------HMN-----IVNLLGACT--I-----GGPTL--VITEYCCYG--DLLNFLR-----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELAL---DLEDLLSFSYQVAKGMAFLAS--K---N---CIHRDLAARNILLT--H--------GRIT--------KICDFGLARDI--K-N--DSNY--VVKGNARLPVKWMAPESIF------NCV--YTFESDVWSYGIFLWELFSLGSSP-------------YPGM-P--VDSKF-YKMI-KEGFRMLSPEHAP-----------------------------------------------------------------------------AEMYDIMKTCWDADPLKRPT-----FK-QIVQL--I------------
--EFL------LGDGSFGSVYRAAYE-----GEE---VAVKIF---NKH--T-SLRLL-----R-Q-----------------------------ELVVLCHL--H------HPS-----LISLLAAGI--R-----P--RM--LVMELASKG--SLDRLLQ---QDKA-----------------------------------------------------------------------------SL---TRTLQHRIALHVADGLRYLHS--A---M---IIYRDLKPHNVLLF--T--------LY-PNAA--IIAKIADYGIAQ------YCCRMGI--KT---SEGTPGFRAPEVAR-----GNVI--YNQQADVYSFGLLLYDILTTGGRI-------------VEGLK-FPNEFDE-LEIQ-GKLPDPVKEYGCAPW---------------------------------------------------------------------------PMVEKLIKQCLKENPQERPT-----SA-QVF-----DIL---------
-----YTTMRQLGDGTYGSVLMGKSN-----ESGE-LVAIKRM---KRK--F-YSWDE-----C-M-NLR-------------------------EVKSLKKL--N------HAN-----VIKLKEVIR--E-----NDHLY--FIFEYMKE---NLYQLMK---DRNK-----------------------------------------------------------------------------LF---PESVIRNIMYQILQGLAFIHK--H---G---FFHRDMKPENLLCM--G--------PELV--------KIADFGLARE-----LRSQPPY--TD---YVSTRWYRAPEVLL-----RSSV--YSSPIDVWAVGSIMAELYM-LRPL-------------FPGT----SEVDE-IFKI-CQVLGTPKKSDWPEGYQLASSMNFRFPQCV------------------------------------------------PINLKTLIPNASNEAIQLMTEMLNWDPKKRPT-----AS-QALKHPYF------------
-----LRLEEVIGIGGFGKVYRGSWR-------GE-LVAVKAA---R-Q--D-PD-EDISVTAE-SVR-Q-------------------------EARLFAML--A------HPN-----IIALKAVCL--E-----EPNLC--LVMEYAAGG--PLSRALA-----GR-----------------------------------------------------------------------------RV---PPHVLVNWAVQIARGMHYLHC--E---ALVPVIHRDLKSNNILLL--QPIESDDMEHKTL--------KITDFGLAREW---------HK--TTQMSAAGTYAWMAPEVIK------AST--FSKGSDVWSFGVLLWELLT-GEVP-------------YRGI----DCLAV-AYGVAVNKLTLPIPSTCP-----------------------------------------------------------------------------EPFAQLMADCWAQDPHRRPD-----FA-SILQQL--------------
LDLQW------VGSGAQGAVFLGRFH-------GE-EVAVKKV---R-D--L-KE-T--------------------------------------DIKHLRKL--K------HPN-----IITFKGVCT--Q-----APCYC--ILMEFCAQG--QLYEVLR-----AG----------------------------------------------------------------------------RPV---TPSLLVDWSMGIAGGMNYLHL--H---K---IIHRDLKSPNMLIT--Y--------DDVV--------KISDFGTSKEL--------SDK--STKMSFAGTVAWMAPEVIR------NEP--VSEKVDIWSFGVVLWELLT-GEIP-------------YKDV----DSSAI-IWGVGSNSLHLPVPSSCP-----------------------------------------------------------------------------DGFKILLRQCWNSKPRNRPS-----FR-QILLH--L------------
-ISEL----QWLGSGAQGAVFLGKFR-------AE-EVAIKKV---R-E--Q-NE-TD--------------------------------------IKHLRKL--K------HPN-----IIAFKGVCT--Q-----APCYC--IIMEYCAHG--QLYEVLR-----AG----------------------------------------------------------------------------RKI---TPRLLVDWSTGIASGMNYLHL--H---K---IIHRDLKSPNVLVT--H--------TDAV--------KISDFGTSKEL--------SDK--STKMSFAGTVAWMAPEVIR------NEP--VSEKVDIWSFGVVLWELLT-GEIP-------------YKDV----DSSAI-IWGVGSNSLHLPVPSTCP-----------------------------------------------------------------------------DGFKILMKQTWQSKPRNRPS-----FR-QTLMH--L------------
----L-TLEEIIGIGGFGKVYRAFWI-----GDE---VAVKAA---RHDP-D-EDISQ-----T-IENVR------------------------QEAKLFAML--K------HPN-----IIALRGVCL--K-----EPNLC--LVMEFARGG--PLNRVLS-----GK-----------------------------------------------------------------------------RI---PPDILVNWAVQIARGMNYLHD--EAIVP---IIHRDLKSSNILIL--Q--------KVENGDLSNKILKITDFGLAR------EWHRTTK--MS---AAGTYAWMAPEVIR------ASM--FSKGSDVWSYGVLLWELLT-GEVP-------------FRGI-------DG-LAVA-YGVAMNKLALPIPSTCP-------------------------------------------------------------------------EPFAKLMEDCWNPDPHSRPS-----FT-NILDQ---LT----------
--KVT---SQVLGLGINGKVLQIFNK-----RTQE-KFALKML---QDC--P-KAR-------------R-------------------------EVELHWRA-SQ------CPH-----IVRIVDVYE--NLY-AGRKCLL--IVMECLDGG--ELFSRIQD--RGDQ-----------------------------------------------------------------------------AF---TEREASEIMKSIGEAIQYLHS--I---N---IAHRDVKPENLLYT--S--------KRPNA-----ILKLTDFGFAKE-----TTSHNSL--TT---PCYTPYYVAPEVLG------PEK--YDKSCDMWSLGVIMYILLC-GYPP-------------FYSN---HGLAIS-PGMK-TRIRMGQYEFPNPEWSEVS-----------------------------------------------------------------------EEVKMLIRNLLKTEPTQRMT-----IT-EFMNHPWI------------
-----VHFNEVIGRGHFGCVYHGTLL--DNDGKKI-HCAVKSL---N-R--I-TD-IGE---VS-QFL-T-------------------------EGIIMKDF--S------HPN-----VLSLLGICL-RS-----EGSPL--VVLPYMKHG--DLRNFIR-----NE---------------------------------------------------------------------------THNP---TVKDLIGFGLQVAKGMKYLAS--K---K---FVHRDLAARNCMLD--E--------KFTV--------KVADFGLARDM--Y-D--KEYYSVHNKTGAKLPVKWMALESLQ------TQK--FTTKSDVWSFGVLLWELMTRGAPP-------------YPDV----NTFDI-TVYL-LQGRRLLQPEYCP-----------------------------------------------------------------------------DPLYEVMLKCWHPKAEMRPS-----FS-ELVSR--I------------
-----FTKLERIGKGSFGEVFKGIDN-----RTQQ-VVAIKII---DLE--E-AEDEI-----E-DIQ-Q-------------------------EITVLSQC--D------SSY-----VTKYYGSYL--K-----GSKLW--IIMEYLGGG--SALDLLR-----AG-----------------------------------------------------------------------------PF---DEFQIATMLKEILKGLDYLHS--E---K---KIHRDIKAANVLLS--E--------QGDV--------KLADFGVAGQL----TDTQIKR--NT---FVGTPFWMAPEVIQ------QSA--YDSKADIWSLGITAIELAK-GEPP-------------NSDM----HPMRV-LFLI-PKNNPPTLVGDFT-----------------------------------------------------------------------------KSFKEFIDACLNKDPSFRPT-----AK-ELLKHKFI------------
----I-EYVRDIGEGAFGRVFQARAPGLLPYEPFT-MVAVKML---K-E--E-AS-ADM---QA-DFQ-R-------------------------EAALMAEF--D------NPN-----IVKLLGVCA--V-----GKPMC--LLFEYMAYG--DLNEFLR-----SMSPHTVCSLSHS----------------------------------------------------DLSMRAQVSSPGPPPL---SCAEQLCIARQVAAGMAYLSE--R---K---FVHRDLATRNCLVG--E--------NMVV--------KIADFGLSRNI--Y-S--ADYY--KANENDAIPIRWMPPESIF------YNR--YTTESDVWAYGVVLWEIFSYGLQP-------------YYGM----AHEEV-IYYV-RDGNILSCPENCP-----------------------------------------------------------------------------VELYNLMRLCWSKLPADRPS-----FT-SIHRIL--------------
----I-VLKRELGEGAFGKVFLAECYNLCPEQDKI-LVAVKTL---K-D--A-SD-NA----RK-DFH-R-------------------------EAELLTNL--Q------HEH-----IVKFYGVCV--E-----GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAV---------------------------------------------------------------LMAEGNPPTEL---TQSQMLHIAQQIAAGMVYLAS--Q---H---FVHRDLATRNCLVG--E--------NLLV--------KIGDFGMSRDV--Y-S--TDYY--RVGGHTMLPIRWMPPESIM------YRK--FTTESDVWSLGVVLWEIFTYGKQP-------------WYQL----SNNEV-IECI-TQGRVLQRPRTCP-----------------------------------------------------------------------------QEVYELMLGCWQREPHMRKN-----IK-GIHTL--L------------
-DNFI-----KIGEGSTGIVCIATVR-----SSGK-LVAVKKM---DLR--K-QQRRE-----L---LFN-------------------------EVVIMRDY--Q------HEN-----VVEMYNSYL--V-----GDELW--VVMEFLEGG--ALTDIVT-----HT-----------------------------------------------------------------------------RM---NEEQIAAVCLAVLQALSVLHA--Q---G---VIHRDIKSDSILLT--H--------DGRV--------KLSDFGFCAQV----SKEVPRR--KS---LVGTPYWMAPELIS------RLP--YGPEVDIWSLGIMVIEMVD-GEPP-------------YFNE----PPLKA-MKMI-RDNLPPRLKNLHKVS---------------------------------------------------------------------------PSLKGFLDRLLVRDPAQRAT-----AA-ELLKHPFL------------
-----YEPKEILGRGVSSVVRRCIHK-----PTSQ-EYAVKVI---DVT--G-GGSFS-----P-EEVRELRE------------------ATLKEVDILRKV-SG------HPN-----IIQLKDTYE--T-----NTFFF--LVFDLMKRG--ELFDYLT----EKV-----------------------------------------------------------------------------TL---SEKETRKIMRALLEVICTLHK--L---N---IVHRDLKPENILLD--D--------NMNI--------KLTDFGFSCQ-----LEPGERL--RE---VCGTPSYLAPEIIECSMNEDHPG--YGKEVDMWSTGVIMYTLLA-GSPP-------------FWHR-------KQ-MLML-RMIMSGNYQFGSPEWDDYS-----------------------------------------------------------------------DTVKDLVSRFLVVQPQNRYT-----AE-EALAHPFF------------
--YDP---KDVIGRGVSSVVRRCVHR-----ATGH-EFAVKIM---EVT--A-ERLSP-----E-QLEEVREA-------------------TRRETHILRQV-AG------HPH-----IITLIDSYE--S-----SSFMF--LVFDLMRKG--ELFDYLT----EKV-----------------------------------------------------------------------------AL---SEKETRSIMRSLLEAVSFLHA--N---N---IVHRDLKPENILLD--D--------NMQI--------RLSDFGFSCH-----LEPGEKL--RE---LCGTPGYLAPEILKCSMDETHPG--YGKEVDLWACGVILFTLLA-GSPP-------------FWHR-------RQ-ILML-RMIMEGQYQFSSPEWDDRS-----------------------------------------------------------------------STVKDLISRLLQVDPEARLT-----AE-QALQHPFF------------
---FR--CCAVLGRGHFGKVLLAEYK-----NTNE-MFAIKAL---KKG--D-IVARD-----E-VDSLM------------------------CEKRIFETV--NS---VRHPF-----LVNLFACFQ--T-----KEHVC--FVMEYAAGG--DLMMHIH-----TD-----------------------------------------------------------------------------VF---SEPRAVFYAACVVLGLQYLHE--H---K---IVYRDLKLDNLLLD--T--------EGFV--------KIADFGLCKEG----MGYGDRT--ST---FCGTPEFLAPEVLT------ETS--YTRAVDWWGLGVLIYEMLV-GESP-------------FPGD-------DE-EEVF-DSIVNDEVRYPRFLS---------------------------------------------------------------------------TEAISIMRRLLRRNPERRLGASEKDAE-DVKKHPFF------------
----Y-CRGKVLGKGGFAKCYEMTDL-----TNNK-VYAAKII---PHS--R-VAKPH-----Q-REKID------------------------KEIELHRIL--H------HKH-----VVQFYHYFE--D-----KENIY--ILLEYCSRR--SMAHILK----ARK-----------------------------------------------------------------------------VL---TEPEVRYYLRQIVSGLKYLHE--Q---E---ILHRDLKLGNFFIN--E--------AMEL--------KVGDFGLAARL----EPLEHRR--RT---ICGTPNYLSPEVLN------KQG--HGCESDIWALGCVMYTMLL-GRPP-------------FETT-------NL-KETY-RCIREARYTMPSSLL---------------------------------------------------------------------------APAKHLIASMLSKNPEDRPS-----LD-DIIRHDFF------------
---FI--LHKMLGKGSFGKVFLAEFK-----KTNQ-FFAIKAL---KKD--V-VLMDD-----D-VECTM------------------------VEKRVLSLA-WE------HPF-----LTHMFCTFQ--T-----KENLF--FVMEYLNGG--DLMYHIQ----SCH-----------------------------------------------------------------------------KF---DLSRATFYAAEIILGLQFLHS--K---G---IVYRDLKLDNILLD--K--------DGHI--------KIADFGMCKEN----MLGDAKT--NT---FCGTPDYIAPEILL------GQK--YNHSVDWWSFGVLLYEMLI-GQSP-------------FHGQ-------DE-EELF-HSIRMDNPFYPRWLE---------------------------------------------------------------------------KEAKDLLVKLFVREPEKRLG-----VRGDIRQHPLF------------
----F-TLCRKLGSGYFGEVFEGLWK------DRV-QVAIKVI---S-R--D-NL-LH----QQ-MLQ-S-------------------------EIQAMKKL--R------HKH-----ILALYAVVS--V-----GDPVY--IITELMAKG--SLLELLR-----DS--------------------------------------------------------------------------DEKVL---PVSELLDIAWQVAEGMCYLES--Q---N---YIHRDLAARNILVG--E--------NTLC--------KVGDFGLARLI-------KEDV--YLSHDHNIPYKWTAPEALS------RGH--YSTKSDVWSFGILLHEMFSRGQVP-------------YPGM----SNHEA-FLRV-DAGYRMPCPLECP-----------------------------------------------------------------------------PSVHKLMLTCWCRDPEQRPC-----FK-ALRERL--------------
----L-VLGKTLGEGEFGKVVKATAFHLKGRAGYT-TVAVKML---K-E--N-AS-PSE---LR-DLL-S-------------------------EFNVLKQV--N------HPH-----VIKLYGACS--Q-----DGPLL--LIVEYAKYG--SLRGFLR-----ESRKVGPGYLGSG----------------------------------------------------GSRNSSSLDHPDERAL---TMGDLISFAWQISQGMQYLAE--M---K---LVHRDLAARNILVA--E--------GRKM--------KISDFGLSRDV--Y-E--EDSY--VKRSQGRIPVKWMAIESLF------DHI--YTTQSDVWSFGVLLWEIVTLGGNP-------------YPGI----PPERL-FNLL-KTGHRMERPDNCS-----------------------------------------------------------------------------EEMYRLMLQCWKQEPDKRPV-----FA-DISKDL--------------
-----YELVRELGKGTYGKVDLVVYK-----GTGT-KMALKFV---NKS--K-TKLKN-----F----LR-------------------------EVSITNSL-SS------SPF-----IIKVFDVVF--E----TEDCYV--FAQEYAPAG--DLFDIIP----PQV-----------------------------------------------------------------------------GL---PEDTVKRCVQQLGLALDFMHG--R---Q---LVHRDIKPENVLLFDRE--------CRRV--------KLADFGMTR-------RVGCRV--KR---VSGTIPYTAPEVCQAG-RADGLA--VDTGVDVWAFGVLIFCVLT-GNFP-------------WEAA----SGADAFFEEF-VRWQRGRLPGLPSQWRRFT-----------------------------------------------------------------------EPALRMFQRLLALEPERRGP-----AK-EVF-----RFLKH-------
-----WEIIGELGDGAFGKVYKAQNK-----ETSV-LAAAKVI---DTK--S-EEELE-----D-YM--V-------------------------EIDILASC--D------HPN-----IVKLLDAFY--Y-----ENNLW--ILIEFCAGG--AVDAVML---ELER-----------------------------------------------------------------------------PL---TESQIQVVCKQTLDALNYLHD--N---K---IIHRDLKAGNILFT--L--------DGDI--------KLADFGVSAKN----TRTIQRR--DS---FIGTPYWMAPEVVMCE-TSKDRP--YDYKADVWSLGITLIEMAE-IEPP-------------HHEL----NPMRV-LLKI-AKSEPPTLAQPSRWS---------------------------------------------------------------------------SNFKDFLKKCLEKNVDARWT-----TS-QLLQHPFV------------
--LCP---GRELGRGKFAVVRKCIKK-----DSGK-EFAAKFM---RKR--R-KGQDC-----R-MEIIH-------------------------EIAVLELA-QD------NPW-----VINLHEVYE--T-----ASEMI--LVLEYAAGG--EIFDQCVA--DREE-----------------------------------------------------------------------------AF---KEKDVQRLMRQILEGVHFLHT--R---D---VVHLDLKPQNILLT--S--------ESPLG-----DIKIVDFGLSRI-----LKNSEEL--RE---IMGTPEYVAPEILS------YDP--ISMATDMWSIGVLTYVMLT-GISP-------------FLGN-------DK-QETF-LNISQMNLSYSEEEFDVLS-----------------------------------------------------------------------ESAVDFIRTLLVKKPEDRAT-----AE-ECLKHPWL------------
--ILT---SKELGRGKFAVVRQCISK-----STGQ-EYAAKFL---KKR--R-RGQDC-----R-AEILH-------------------------EIAVLELA-KS------CPR-----VINLHEVYE--N-----TSEII--LILEYAAGG--EIFSLCLP--ELAE-----------------------------------------------------------------------------MV---SENDVIRLIKQILEGVYYLHQ--N---N---IVHLDLKPQNILLS--S--------IYPLG-----DIKIVDFGMSRK-----IGHACEL--RE---IMGTPEYLAPEILN------YDP--ITTATDMWNIGIIAYMLLT-HTSP-------------FVGE-------DN-QETY-LNISQVNVDYSEETFSSVS-----------------------------------------------------------------------QLATDFIQSLLVKNPEKRPT-----AE-ICLSHSWL------------
-----FTKLEKIGKGSFGEVFKGIDN-----RTQK-VVAIKII---DLE--E-AEDEI-----E-DIQ-Q-------------------------EITVLSQC--D------SPY-----VTKYYGSYL--K-----DTKLW--IIMEYLGGG--SALDLLE-----PG-----------------------------------------------------------------------------PL---DETQIATILREILKGLDYLHS--E---K---KIHRDIKAANVLLS--E--------HGEV--------KLADFGVAGQL----TDTQIKR--NT---FVGTPFWMAPEVIK------QSA--YDSKADIWSLGITAIELAR-GEPP-------------HSEL----HPMKV-LFLI-PKNNPPTLEGNYS-----------------------------------------------------------------------------KPLKEFVEACLNKEPSFRPT-----AK-ELLKHKFI------------
----F-TKLDRIGKGSFGEVYKGIDN-----HTKE-VVAIKII---DLE--E-AEDEI-----E-DIQ-Q-------------------------EITVLSQC--D------SPY-----ITRYFGSYL--K-----STKLW--IIMEYLGGG--SALDLLK-----PG-----------------------------------------------------------------------------PL---EETYIATILREILKGLDYLHS--E---R---KIHRDIKAANVLLS--E--------QGDV--------KLADFGVAGQL----TDTQIKR--NT---FVGTPFWMAPEVIK------QSA--YDFKADIWSLGITAIELAK-GEPP-------------NSDL----HPMRV-LFLI-PKNSPPTLEGQHS-----------------------------------------------------------------------------KPFKEFVEACLNKDPRFRPT-----AK-ELLKHKFI------------
--VCR---GELLGSGCFGVVHRGLWT--LPSGKSV-PVAVKSLRVGP-E--G-PM-GTE---LG-DFL-R-------------------------EVSVMMNL--E------HPH-----VLRLHGLVL--------GQPLQ--MVMELAPLG--SLHARLT-----AP-------------------------------------------------------------------------APTPPL---LVALLCLFLRQLAGAMAYLGA--R---G---LVHRDLATRNLLLA--S--------PRTI--------KVADFGLVRPL-GG-A--RGRY--VMGGPRPIPYAWCAPESLR------HGA--FSSASDVWMFGVTLWEMFSGGEEP-------------WAGV----PPYLI-LQRL-EDRARLPRPPLCS-----------------------------------------------------------------------------RALYSLALRCWAPHPADRPS-----FS-HLE----GLL----------
----L-RLLEKLGDGSFGVVRRGEWD--APSGKTV-SVAVKCL---K-PDVL-SQ-PEA---MD-DFI-R-------------------------EVNAMHSL--D------HRN-----LIRLYGVVL--------TPPMK--MVTELAPLG--SLLDRLR-----KH---------------------------------------------------------------------------QGHF---LLGTLSRYAVQVAEGMGYLES--K---R---FIHRDLAARNLLLA--T--------RDLV--------KIGDFGLMRAL-PQ-N--DDHY--VMQEHRKVPFAWCAPESLK------TRT--FSHASDTWMFGVTLWEMFTYGQEP-------------WIGL----NGSQI-LHKIDKEGERLPRPEDCP-----------------------------------------------------------------------------QDIYNVMVQCWAHKPEDRPT-----FV-ALRDF--L------------
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