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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FGR 203
TK ABL1 261
TK ABL2 288
TK CSF1R 582
TK DDR1 572
TK EPHA3 621
TK EPHA7 633
TK EPHA8 635
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FLT1 827
TK FLT4 845
TK FRK 234
TK FYN 271
TK INSR 1023
TK JAK2 849
TK KDR 834
TK KIT 589
TK LCK 245
TK LYN 247
TK MATK 235
TK MUSK 575
TK NTRK2 538
TK NTRK3 538
TK PDGFRA 593
TK PDGFRB 600
TK PTK6 191
TKL RIPK1 17
TK SRC 270
TK SRMS 230
TK TEK 824
TK TIE1 839
TK TNK1 116
TK TNK2 150
TK YES1 277
---ITLERRLGTGCFGDVWLGTWN-----------------GSTKVAVKTL---KP--GTMSP--KAFLEEAQVMKLL-RHDKLVQLYAVVS---EEPIYIVTEFMCHGSLLDFLKNP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLI--------KDDEY--------------NPCQGSKFPIKWTAPEAALFGR--FTIKSDVWSFGILLTELITKGR-IP---------------YPGM-NKREVLEQV----EQGYH---MP---CPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFL---
---ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTL---KE--DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT--REPPFYIITEFMTYGNLLDYLREC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--------TGDTY--------------TAHAGAKFPIKWTAPESLAYNK--FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQVYELL----EKDYR---ME---RPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F--
---ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTL---KE--DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT--LEPPFYIVTEYMPYGNLLDYLREC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM--------TGDTY--------------TAHAGAKFPIKWTAPESLAYNT--FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQVYDLL----EKGYR---ME---QPEGCPPKVYELMRACWKWSPADRPSFAETHQA-F--
---LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAVKML---KS--TAHADEKEALMSELKIMSHLGQHENIVNLLGACT--HGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI-------MNDSNY--------------IVKGNARLPVKWMAPESIFDCV--YTVQSDVWSYGILLWEIFSLGL-NP---------------YPGILVNSKFYKLV----KDGYQ---MA---QPAFAPKNIYSIMQACWALEPTHRPTFQQICSFL---
---LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL---RP--DATKNARNDFLKEVKIMSRL-KDPNIIRLLGVCV--QDDPLCMITDYMENGDLNQFLSAHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNL-------YAGDYY--------------RVQGRAVLPIRWMAWECILMGK--FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL-TDEQVIENAGEFFRDQGRQVYLS---RPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL---
--I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEISVAIKTL---KV--GYTEKQRRDFLGEASIMGQF-DHPNIIRLEGVVT--KSKPVMIVTEYMENGSLDSFLRKH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVL-------EDDPEA-------------AYTTRGGKIPIRWTSPEAIAYRK--FTSASDVWSYGIVLWEVMSYGE-RP---------------YWEM-SNQDVIKAV----DEGYR---LP---PPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSIL---
---IKIERVIGAGEFGEVCSGRLK-------------LPGKRDVAVAIKTL---KV--GYTEKQRRDFLCEASIMGQF-DHPNVVHLEGVVT--RGKPVMIVIEFMENGALDAFLRKH--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVI-------EDDPEA-------------VYTTTGGKIPVRWTAPEAIQYRK--FTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM-SNQDVIKAI----EEGYR---LP---APMDCPAGLHQLMLDCWQKERAERPKFEQIVGI-L--
---IHIEKIIGSGDSGEVCYGRLR-------------VPGQRDVPVAIKAL---KA--GYTERQRRDFLSEASIMGQF-DHPNIIRLEGVVT--RGRLAMIVTEYMENGSLDTFLRTH--------------------------------------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVL-------EDDPDA-------------AYTTTGGKIPIRWTAPEAIAFRT--FSSASDVWSFGVVMWEVLAYGE-RP---------------YWNM-TNRDVISSV----EEGYR---LP---APMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVL---
--L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKML---KS--DATEKDLSDLISEMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLQARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI-------HHIDYY--------------KKTTNGRLPVKWMAPEALFDRI--YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV-PVEELFKLL----KEGHR---MD---KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL---
---LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAVKML---KD--DATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLRARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI-------NNIDYY--------------KKTTNGRLPVKWMAPEALFDRV--YTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI-PVEELFKLL----KEGHR---MD---KPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL---
---LTLGKPLGEGCFGQVVMAEAIGI---------DKDRAAKPVTVAVKML---KD--DATDKDLSDLVSEMEMMKMIGKHKNIINLLGACT--QGGPLYVLVEYAAKGNLREFLRARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDV-------HNLDYY--------------KKTTNGRLPVKWMAPEALFDRV--YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI-PVEELFKLL----KEGHR---MD---KPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL---
--L-VLGKPLGEGCFGQVVRAEAFGM---------DPARPDQASTVAVKML---KD--NASDKDLADLVSEMEVMKLIGRHKNIINLLGVCT--QEGPLYVIVECAAKGNLREFLRARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGV-------HHIDYY--------------KKTSNGRLPVKWMAPEALFDRV--YTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI-PVEELFSLL----REGHR---MD---RPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL---
---LKLGKSLGRGAFGKVVQASAFG-----------IKKSPTCRTVAVKML---KE--GATASEYKALMTELKILTHIGHHLNVVNLLGACT-KQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPR--------------------------------LDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDI-------YKNPDY--------------VRKGDTRLPLKWMAPESIFDKI--YSTKSDVWSYGVLLWEIFSLGG-SP---------------YPGVQMDEDFCSRL----REGMR---MR---APEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL---
---LHLGRVLGYGAFGKVVEASAFG-----------IHKGSSCDTVAVKML---KE--GATASEHRALMSELKILIHIGNHLNVVNLLGACT-KPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDI-------YKDPDY--------------VRKGSARLPLKWMAPESIFDKV--YTTQSDVWSFGVLLWEIFSLGA-SP---------------YPGVQINEEFCQRL----RDGTR---MR---APELATPAIRRIMLNCWSGDPKARPAFSELVEIL---
---IQLLKRLGSGQFGEVWEGLWN-----------------NTTPVAVKTL---KP--GSMDP--NDFLREAQIMKNL-RHPKLIQLYAVCT--LEDPIYIITELMRHGSLQEYLQND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFK-----VDNEDIY--------------ESRHEIKLPVKWTAPEAIRSNK--FSIKSDVWSFGILLYEIITYGK-MP---------------YSGM-TGAQVIQML----AQNYR---LP---QPSNCPQQFYNIMLECWNAEPKERPTFETLRWK-L--
---LQLIKRLGNGQFGEVWMGTWN-----------------GNTKVAIKTL---KP--GTMSP--ESFLEEAQIMKKL-KHDKLVQLYAVVS---EEPIYIVTEYMNKGSLLDFLKDG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI--------EDNEY--------------TARQGAKFPIKWTAPEAALYGR--FTIKSDVWSFGILLTELVTKGR-VP---------------YPGM-NNREVLEQV----ERGYR---MP---CPQDCPISLHELMIHCWKKDPEERPTFEYLQSFL---
---ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAVKTV---NE--SASLRERIEFLNEASVMKGF-TCHHVVRLLGVVS--KGQPTLVVMELMAHGDLKSYLRSLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI-------YETDYY--------------RKGGKGLLPVRWMAPESLKDGV--FTTSSDMWSFGVVLWEITSLAE-QP---------------YQGL-SNEQVLKFV----MDGGY---LD---QPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL---
---LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAVKKL---QH--STE-EHLRDFEREIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVL------PQDKEYY--------------KVKEPGESPIFWYAPESLTESK--FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM-IVFHLIELL----KNNGR---LP---RPDGCPDEIYMIMTECWNNNVNQRPSFRDLA---LRV
---LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAVKML---KE--GATHSEHRALMSELKILIHIGHHLNVVNLLGACT-KPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI-------YKDPDY--------------VRKGDARLPLKWMAPETIFDRV--YTIQSDVWSFGVLLWEIFSLGA-SP---------------YPGVKIDEEFCRRL----KEGTR---MR---APDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL---
---LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAVKML---KP--SAHLTEREALMSELKVLSYLGNHMNIVNLLGACT--IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI-------KNDSNY--------------VVKGNARLPVKWMAPESIFNCV--YTFESDVWSYGIFLWELFSLGS-SP---------------YPGMPVDSKFYKMI----KEGFR---ML---SPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQL-I--
---LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSL---KQ--GSMSP--DAFLAEANLMKQL-QHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLKTP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--------EDNEY--------------TAREGAKFPIKWTAPEAINYGT--FTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM-TNPEVIQNL----ERGYR---MV---RPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L--
---IKLVKRLGAGQFGEVWMGYYN-----------------NSTKVAVKTL---KP--GTMSV--QAFLEEANLMKTL-QHDKLVRLYAVVT--REEPIYIITEYMAKGSLLDFLKSD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVI--------EDNEY--------------TAREGAKFPIKWTAPEAINFGC--FTIKSDVWSFGILLYEIVTYGK-IP---------------YPGR-TNADVMTAL----SQGYR---MP---RVENCPDELYDIMKMCWKEKAEERPTFDYLQSV-L--
---LTLGAQIGEGEFGAVLQGEYL------------------GQKVAVKNI---KC--DVTAQ---AFLDETAVMTKM-QHENLVRLLGVIL---HQGLYIVMEHVSKGNLVNFLRTR-------------------------------------------------------------------------------------------------GRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAE------------R--------------KGLDSSRLPVKWTAPEALKHGK--FTSKSDVWSFGVLLWEVFSYGR-AP---------------YPKM-SLKEVSEAV----EKGYR---ME---PPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKL---
--I-EYVRDIGEGAFGRVFQARAPG-----------LLPYEPFTMVAVKML---KE--EASADMQADFQREAALMAEF-DNPNIVKLLGVCA--VGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNI-------YSADYY--------------KANENDAIPIRWMPPESIFYNR--YTTESDVWAYGVVLWEIFSYGL-QP---------------YYGM-AHEEVIYYV----RDGNI---LS---CPENCPVELYNLMRLCWSKLPADRPSFTSIHRIL---
--I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKILVAVKTL---KD--ASDNA-RKDFHREAELLTNL-QHEHIVKFYGVCV--EGDPLIMVFEYMKHGDLNKFLRAHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDV-------YSTDYY--------------RVGGHTMLPIRWMPPESIMYRK--FTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL-SNNEVIECI----TQGRV---LQ---RPRTCPQEVYELMLGCWQREPHMRKNIKGIHTL-L--
--I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKMLVAVKAL---KD--PTLAA-RKDFQREAELLTNL-QHEHIVKFYGVCG--DGDPLIMVFEYMKHGDLNKFLRAHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDV-------YSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRK--FTTESDVWSFGVILWEIFTYGK-QP---------------WFQL-SNTEVIECI----TQGRV---LE---RPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL---
--L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAVKML---KP--TARSSEKQALMSELKIMTHLGPHLNIVNLLGACT--KSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI-------MHDSNY--------------VSKGSTFLPVKWMAPESIFDNL--YTTLSDVWSYGILLWEIFSLGG-TP---------------YPGMMVDSTFYNKI----KSGYR---MA---KPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE--IV-
--L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAVKML---KS--TARSSEKQALMSELKIMSHLGPHLNVVNLLGACT--KGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI-------MRDSNY--------------ISKGSTFLPLKWMAPESIFNSL--YTTLSDVWSFGILLWEIFTLGG-TP---------------YPELPMNEQFYNAI----KRGYR---MA---QPAHASDEIYEIMQKCWEEKFEIRPPFSQLVL--LL-
--F-TLCRKLGSGYFGEVFEGLWK-----------------DRVQVAIKVI---SR--DNLLH-QQMLQSEIQAMKKL-RHKHILALYAVVS--VGDPVYIITELMAKGSLLELLRDS-------------------------------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLI---------KEDV--------------YLSHDHNIPYKWTAPEALSRGH--YSTKSDVWSFGILLHEMFSRGQ-VP---------------YPGM-SNHEAFLRV----DAGYR---MP---CPLECPPSVHKLMLTCWCRDPEQRPCFKALRERL---
LES----AELDSGGFGKVSLCFHR-----------------TQGLMIMKTV--YKG--PNCIEHNEALLEEAKMMNRL-RHSRVVKLLGVII--EEGKYSLVMEYMEKGNLMHVLKAE---------------------------------------------------------------------------------------------------MSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNE--EHNELR--------EVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFA-NK-EP---------------YENAICEQQLIMCI----KSGNR---PDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEK-F--
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAIKTL---KP--GTMSP--EAFLQEAQVMKKL-RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKGE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--------EDNEY--------------TARQGAKFPIKWTAPEAALYGR--FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM-VNREVLDQV----ERGYR---MP---CPPECPESLHDLMCQCWRKEPEERPTFEYLQAF-L--
-FA--LGRKLGEGYFGEVWEGLWL-----------------GSLPVAIKVI---KS--ANMK--LTDLAKEIQTLKGL-RHERLIRLHAVCS--GGEPVYIVTELMRKGNLQAFLGTP-------------------------------------------------------------------------------------------------EGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLL--------KDDIY--------------SPSSSSKIPVKWTAPEAANYRV--FSQKSDVWSFGVLLHEVFTYGQ-CP---------------YEGM-TNHETLQQI----MRGYR---LP---RPAACPAEVYVLMLECWRSSPEERPSFATLREKL---
---IKFQDVIGEGNFGQVLKARIK--------------KDGLRMDAAIKRM---KE--YASKDDHRDFAGELEVLCKLGHHPNIINLLGACE--HRGYLYLAIEYAPHGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ----------EVY--------------VKKTMGRLPVRWMAIESLNYSV--YTTNSDVWSYGVLLWEIVSLGG-TP---------------YCGM-TCAELYEKL----PQGYR---LE---KPLNCDDEVYDLMRQCWREKPYERPSFAQILV--SL-
---ITFEDLIGEGNFGQVIRAMIK--------------KDGLKMNAAIKML---KE--YASENDHRDFAGELEVLCKLGHHPNIINLLGACK--NRGYLYIAIEYAPYGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGE----------EVY--------------VKKTMGRLPVRWMAIESLNYSV--YTTKSDVWSFGVLLWEIVSLGG-TP---------------YCGM-TCAELYEKL----PQGYR---ME---QPRNCDDEVYELMRQCWRDRPYERPPFAQIALQ-L--
VCR---GELLGSGCFGVVHRGLWT-------------LPSGKSVPVAVKSLRVGPE--GPMGTELGDFLREVSVMMNL-EHPHVLRLHGLVL---GQPLQMVMELAPLGSLHARLTAP------------------------------------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPL------GGARGRY--------------VMGGPRPIPYAWCAPESLRHGA--FSSASDVWMFGVTLWEMFSGGE-EP---------------WAGV-PPYLILQRL----EDRAR---LP---RPPLCSRALYSLALRCWAPHPADRPSFSHLE---GLL
--L-RLLEKLGDGSFGVVRRGEWD-------------APSGKTVSVAVKCL---KPDVLSQPEAMDDFIREVNAMHSL-DHRNLIRLYGVVL---TPPMKMVTELAPLGSLLDRLRKH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRAL------PQNDDHY--------------VMQEHRKVPFAWCAPESLKTRT--FSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL-NGSQILHKI---DKEGER---LP---RPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDF-L--
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAIKTL---KP--GTMMP--EAFLQEAQIMKKL-RHDKLVPLYAVVS---EEPIYIVTEFMSKGSLLDFLKEG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLI--------EDNEY--------------TARQGAKFPIKWTAPEAALYGR--FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM-VNREVLEQV----ERGYR---MP---CPQGCPESLHELMNLCWKKDPDERPTFEYIQSFL---
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