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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FGR 203
TK ABL1 261
TK ABL2 288
TK BLK 241
CAMK BRSK1 50
CAMK BRSK2 19
CMGC CDC2 4
CMGC CDK2 4
CMGC CDKL2 4
CAMK CHEK1 9
CAMK CHEK2 220
Other CHUK 15
CMGC CLK2 163
CMGC CLK3 156
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
CMGC DYRK1A 150
CMGC DYRK1B 111
CMGC DYRK2 222
TK EPHB2 621
TK EPHB3 633
TK FGFR1 478
TK FGFR2 481
TK FYN 271
AGC GRK7 191
CMGC GSK3A 119
CMGC GSK3B 56
TK HCK 241
CMGC HIPK1 190
CMGC HIPK2 199
CMGC HIPK3 197
CMGC HIPK4 -1
CAMK HUNK 61
CMGC ICK 4
CAMK KIAA0999 66
TK LCK 245
TK LYN 247
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK11 24
CMGC MAPK14 24
CMGC MAPK6 20
CMGC MAPK8 26
CMGC MAPK9 26
CAMK MARK1 60
CAMK MARK2 53
CAMK MARK3 56
CAMK MARK4 59
CAMK MGC42105 74
CAMK MKNK2 84
Other NEK1 4
Other NEK2 8
Other NEK3 4
Other NEK4 6
Other NEK5 4
Other NEK9 52
CAMK NUAK2 97
STE OXSR1 17
AGC PDPK1 82
CAMK PHKG1 20
CAMK PHKG2 24
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
AGC PRKG1 375
AGC PRKG2 453
AGC PRKX 49
CMGC PRPF4B 687
TK PTK6 191
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA6 73
AGC RPS6KB1 91
CAMK SIK1 27
CAMK SIK2 20
STE SLK 34
TK SRC 270
TK SRMS 230
STE STK10 36
CAMK STK17A 61
CAMK STK17B 33
STE STK24 24
AGC STK32A 23
STE STK39 63
Other TLK2 440
CAMK TSSK1B 12
TK YES1 277
-----ITLERRLGTGCFGDV---WLGTW---N---------GST---KVAVKTLK-PGTM-SP--KA-FL-E-------EAQVMKLL--R------HDK-----LVQLYAVVS---------------EEPIY--IVTEFMCHG--SLLDFLK------------------------NP--------------EGQDL---RLPQLVDMAAQVAEGMAYMER--M-----NYIHRDLRAANILVG--ERLAC--------------------KIADFGLARLI----------K--DDEYNPCQGSKFPIKWTAPEA--AL------FGRFTIKSDVWSFGILLTELITKGRIPYP-GM------------NKREVLEQVEQGYHMPCPPGCP-----------------------------------------------------------------------------ASLYE-AMEQTWRLDPEERPT-----FEYLQSFL-------------
-----ITMKHKLGGGQYGEV---YEGVW---K-------K-YSL---TVAVKTLK-EDTM-EV--EE-FL-K-------EAAVMKEI--K------HPN-----LVQLLGVCTR--------------EPPFY--IITEFMTYG--NLLDYLR------------------------EC--------------NRQEV---NAVVLLYMATQISSAMEYLEK--K-----NFIHRDLAARNCLVG--ENHLV--------------------KVADFGLSRLM----------T--GDTYTAHAGAKFPIKWTAPES--LA------YNKFSIKSDVWAFGVLLWEIATYGMSPYP-GI------------DLSQVYELLEKDYRMERPEGCP-----------------------------------------------------------------------------EKVYE-LMRACWQWNPSDRPS-----FAEIHQA--F-----------
-----ITMKHKLGGGQYGEV---YVGVW---K-------K-YSL---TVAVKTLK-EDTM-EV--EE-FL-K-------EAAVMKEI--K------HPN-----LVQLLGVCTL--------------EPPFY--IVTEYMPYG--NLLDYLR------------------------EC--------------NREEV---TAVVLLYMATQISSAMEYLEK--K-----NFIHRDLAARNCLVG--ENHVV--------------------KVADFGLSRLM----------T--GDTYTAHAGAKFPIKWTAPES--LA------YNTFSIKSDVWAFGVLLWEIATYGMSPYP-GI------------DLSQVYDLLEKGYRMEQPEGCP-----------------------------------------------------------------------------PKVYE-LMRACWKWSPADRPS-----FAETHQA--F-----------
----L-RLVRKLGSGQFGEV---WMGYY---K---------NNM---KVAIKTLK-EGTM-SP--EA-FL-G-------EANVMKAL--Q------HER-----LVRLYAVVT---------------KEPIY--IVTEYMARG--CLLDFLK------------------------TD--------------EGSRL---SLPRLIDMSAQIAEGMAYIER--M-----NSIHRDLRAANILVS--EALCC--------------------KIADFGLARII-------------DSEYTAQEGAKFPIKWTAPEA--IH------FGVFTIKADVWSFGVLLMEVVTYGRVPYP-GM------------SNPEVIRNLERGYRMPRPDTCP-----------------------------------------------------------------------------PELYRGVIAECWRSRPEERPT-----FEFLQSV--L-----------
-----YRLEKTLGKGQTGLV---KLGVH---C-------I-TGQ---KVAIKIVNREKLSESV--LM-KVER-------EIAILKLI--E------HPH-----VLKLHDVYEN--------------KKYLY--LVLEHVSGG--ELFDYLV-----------------------KKG-----------------RL---TPKEARKFFRQIVSALDFCHS--Y-----SICHRDLKPENLLLD--EKNNI--------------------RIADFGMASL-----------QVGDSLLET---SCGSPHYACPEV--IK-----GEKYDGRRADMWSCGVILFALLV-GALPFD-DD---------------NLRQLLEKVKRGVFHMPHFIP---------------------------------------------------------------------------PDCQS-LLRGMIEVEPEKRLS-----LEQIQKHPW-Y----------
-----YRLEKTLGKGQTGLV---KLGVH---C-------V-TCQ---KVAIKIVNREKLSESV--LM-KVER-------EIAILKLI--E------HPH-----VLKLHDVYEN--------------KKYLY--LVLEHVSGG--ELFDYLV-----------------------KKG-----------------RL---TPKEARKFFRQIISALDFCHS--H-----SICHRDLKPENLLLD--EKNNI--------------------RIADFGMASL-----------QVGDSLLET---SCGSPHYACPEV--IR-----GEKYDGRKADVWSCGVILFALLV-GALPFD-DD---------------NLRQLLEKVKRGVFHMPHFIP---------------------------------------------------------------------------PDCQS-LLRGMIEVDAARRLT-----LEHIQKHIW-Y----------
-----YTKIEKIGEGTYGVV---YKGRH---K-------T-TGQ---VVAMKKIRLESEEEGV--PS-TAIR-------EISLLKEL--R------HPN-----IVSLQDVLMQ--------------DSRLY--LIFEFLSM---DLKKYLDS--------------------IPPGQ-----------------YM---DSSLVKSYLYQILQGIVFCHS--R-----RVLHRDLKPQNLLID--DKGTI--------------------KLADFGLARAF----------GIPIRVYTH---EVVTLWYRSPEV--LL-----GSARYSTPVDIWSIGTIFAELAT-KKPLFH-GD------------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------------------------------------------GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-----GKMALNHPYF-----------
-----FQKVEKIGEGTYGVV---YKARN---K-------L-TGE---VVALKKIRLDTETEGV--PS-TAIR-------EISLLKEL--N------HPN-----IVKLLDVIHT--------------ENKLY--LVFEFLHQ---DLKKFMDA---------------------SALT-----------------GI---PLPLIKSYLFQLLQGLAFCHS--H-----RVLHRDLKPQNLLIN--TEGAI--------------------KLADFGLARAF----------GVPVRTYTH---EVVTLWYRAPEI--LL-----GCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GD------------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-----AKAALAHPFF-----------
-----YENLGLVGEGSYGMV---MKCRN---K-------D-TGR---IVAIKKFLESDDDKMV--KK-IAMR-------EIKLLKQL--R------HEN-----LVNLLEVCKK--------------KKRWY--LVFEFVDHT--ILDDLEL-----------------------FPN-----------------GL---DYQVVQKYLFQIINGIGFCHS--H-----NIIHRDIKPENILVS--QSGVV--------------------KLCDFGFARTL----------AAPGEVYTD---YVATRWYRAPEL--LV-----GDVKYGKAVDVWAIGCLVTEMFM-GEPLFP-GD------------SDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKE-----------------------------------------------REPLERRYPKLSEVVID-LAKKCLHIDPDKRPF-----CAELLHHDFF-----------
----W-DLVQTLGEGAYGEV---QLAVN---R-------V-TEE---AVAVKIVDMKRAVDCP--EN-I-KK-------EICINKML--N------HEN-----VVKFYGHRRE--------------GNIQY--LFLEYCSGG--ELFDRIE-----------------------PDI-----------------GM---PEPDAQRFFHQLMAGVVYLHG--I-----GITHRDIKPENLLLD--ERDNL--------------------KISDFGLATVFR--------YNNRERLLNK---MCGTLPYVAPEL--LK-----RREFHAEPVDVWSCGIVLTAMLA-GELPWD-QP--------------SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------------------------------------------SAPLA-LLHKILVENPSARIT-----IPDIKKDRW-Y----------
---YI--MSKTLGSGACGEV---KLAFE---R-------K-TCK---KVAIKIISKRKFAIGS--AR-EADPALN-VETEIEILKKL--N------HPC-----IIKIKNFF-D--------------AEDYY--IVLELMEGG--ELFDKVV-----------------------GNK-----------------RL---KEATCKLYFYQMLLAVQYLHE--N-----GIIHRDLKPENVLLS--SQEEDC-----------------LIKITDFGHSKI-----------LGETSLMRT---LCGTPTYLAPEV--LVS---VGTAGYNRAVDCWSLGVILFICLS-GYPPFS-EH--------------RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------------------------------------------EKALD-LVKKLLVVDPKARFT-----TEEALRHPWL-----------
----W-EMRERLGTGGFGNV---CLYQH---R-------E-LDL---KIAIKSCRLELSTKNR--ER--WCH-------EIQIMKKL--N------HAN-----VVKACDVPEELN---------ILIHDVPL--LAMEYCSGG--DLRKLLNK--------------------PENCC-----------------GL---KESQILSLLSDIGSGIRYLHE--N-----KIIHRDLKPENIVLQ--DVGGKI-----------------IHKIIDLGYAKD-----------VDQGSLCTS---FVGTLQYLAPEL--FE------NKPYTATVDYWSFGTMVFECIA-GYRPFL-HHLQPFT-WHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCS-----------------------------------------------------------------LVVEPMEN-WLQLMLNWDPQQRG----------------GPVDLTLKQ--
-----YEIVSTLGEGTFGRV---VQCVD---H-------R-RGG--ARVALKIIKNVEKYKEA--AR----L-------EINVLEKI--NEK-DPDNKN----LCVQMFDWFDY--------------HGHMC--ISFELLGL---STFDFLK-----------------------DNN-----------------YLP-YPIHQVRHMAFQLCQAVKFLHD--N-----KLTHTDLKPENILFV--NSDYELTYNLEKKR-DERSVKSTAVRVVDFGSAT-------------FDHEHHST---IVSTRHYRAPEV--IL------ELGWSQPCDVWSIGCIIFEYYV-GFTLFQ-TH------------DNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY----------------------------------VRENCKPLRRYLTSEAEEHHQLFD-LIESMLEYEPAKRLT-----LGEALQHPFF-----------
-----YEIVGNLGEGTFGKV---VECLD---H-------A-RGK--SQVALKIIRNVGKYREA--AR----L-------EINVLKKI--KE---KDKENK--FLCVLMSDWFNF--------------HGHMC--IAFELLGK---NTFEFLK------------------------EN-----------------NFQPYPLPHVRHMAYQLCHALRFLHE--N-----QLTHTDLKPENILFV--NSE-FETLYNEHKSCEEKSVKNTSIRVADFGSAT-------------FDHEHHTT---IVATRHYRPPEV--IL------ELGWAQPCDVWSIGCILFEYYR-GFTLFQ-TH------------ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRY----------------------------------VKENCKPLKSYMLQDSLEHVQLFD-LMRRMLEFDPAQRIT-----LAEALLHPFF-----------
-----YQLVRKLGRGKYSEV---FEAIN---I-------T-NNE---KVVVKILKPVKKKKIK--R-------------EIKILENL-RG------GPN-----IITLADIVKDP------------VSRTPA--LVFEHVNNT--DFKQLY--------------------------Q-----------------TL---TDYDIRFYMYEILKALDYCHS--M-----GIMHRDVKPHNVMID-HEHRKL--------------------RLIDWGLAEF-----------YHPGQEYNV---RVASRYFKGPEL--LV-----DYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGH------------DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----------------------------------------RWERFVHSENQHLVSPEALD-FLDKLLRYDHQSRLT-----AREAMEHPYF-----------
-----YQLVRKLGRGKYSEV---FEAIN---I-------T-NNE---RVVVKILKPVKKKKIK--R-------------EVKILENL-RG------GTN-----IIKLIDTVKDP------------VSKTPA--LVFEYINNT--DFKQLY--------------------------Q-----------------IL---TDFDIRFYMYELLKALDYCHS--K-----GIMHRDVKPHNVMID-HQQKKL--------------------RLIDWGLAEF-----------YHPAQEYNV---RVASRYFKGPEL--LV-----DYQMYDYSLDMWSLGCMLASMIF-RREPFFHGQ------------DNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRK-----------------------------------------RWENFIHSENRHLVSPEALD-LLDKLLRYDHQQRLT-----AKEAMEHPYF-----------
-----YDTGEELGSGQFAVV---KKCRE---K-------S-TGL---QYAAKFIKKRRTKSSR--RG-VSREDI---EREVSILKEI--Q------HPN-----VITLHEVYEN--------------KTDVI--LILELVAGG--ELFDFLA-----------------------EKE-----------------SL---TEEEATEFLKQILNGVYYLHS--L-----QIAHFDLKPENIMLL--DRNVPKP----------------RIKIIDFGLAHK-----------IDFGNEFKN---IFGTPEFVAPEI--VN------YEPLGLEADMWSIGVITYILLS-GASPFL-GD---------------TKQETLANVSAVNYEFEDEYFSNTS-----------------------------------------------------------------------ALAKD-FIRRLLVKDPKKRMT-----IQDSLQHPWI-----------
-----YDIGEELGSGQFAIV---KKCRE---K-------S-TGL---EYAAKFIKKRQSRASR--RG-VSREEI---EREVSILRQV--L------HHN-----VITLHDVYEN--------------RTDVV--LILELVSGG--ELFDFLA-----------------------QKE-----------------SL---SEEEATSFIKQILDGVNYLHT--K-----KIAHFDLKPENIMLL--DKNIPIP----------------HIKLIDFGLAHE-----------IEDGVEFKN---IFGTPEFVAPEI--VN------YEPLGLEADMWSIGVITYILLS-GASPFL-GD---------------TKQETLANITAVSYDFDEEFFSQTS-----------------------------------------------------------------------ELAKD-FIRKLLVKETRKRLT-----IQEALRHPWI-----------
-----YEMGEELGSGQFAIV---RKCRQ---K-------G-TGK---EYAAKFIKKRRLSSSR--RG-VSREEI---EREVNILREI--R------HPN-----IITLHDIFEN--------------KTDVV--LILELVSGG--ELFDFLA-----------------------EKE-----------------SL---TEDEATQFLKQILDGVHYLHS--K-----RIAHFDLKPENIMLL--DKNVPNP----------------RIKLIDFGIAHK-----------IEAGNEFKN---IFGTPEFVAPEI--VN------YEPLGLEADMWSIGVITYILLS-GASPFL-GE---------------TKQETLTNISAVNYDFDEEYFSNTS-----------------------------------------------------------------------ELAKD-FIRRLLVKDPKRRMT-----IAQSLEHSWI-----------
-----YEIDSLIGKGSFGQV---VKAYD---R-------V-EQE---WVAIKIIKNKKAFLNQ--AQ-I----------EVRLLELM-NK------HDTEMKYYIVHLKRHFMF--------------RNHLC--LVFEMLSY---NLYDLLR------------------------NT-----------------NFRGVSLNLTRKFAQQMCTALLFLATPEL-----SIIHCDLKPENILLCNPKRSAI--------------------KIVDFGSSCQ-------------LGQRIYQ---YIQSRFYRSPEV--LL------GMPYDLAIDMWSLGCILVEMHT-GEPLFS-GA------------NEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT--------------RKLHNILGVETGGPGGRRAGESGHTVADYLKFKD-LILRMLDYDPKTRIQ-----PYYALQHSFF-----------
-----YEIDSLIGKGSFGQV---VKAYD---H-------Q-TQE---LVAIKIIKNKKAFLNQ--AQ-I----------ELRLLELM-NQ------HDTEMKYYIVHLKRHFMF--------------RNHLC--LVFELLSY---NLYDLLR------------------------NT-----------------HFRGVSLNLTRKLAQQLCTALLFLATPEL-----SIIHCDLKPENILLCNPKRSAI--------------------KIVDFGSSCQ-------------LGQRIYQ---YIQSRFYRSPEV--LL------GTPYDLAIDMWSLGCILVEMHT-GEPLFS-GS------------NEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGT--------------RRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQD-LVLRMLEYEPAARIS-----PLGALQHGFF-----------
-----YEVLKVIGKGSFGQV---VKAYD---H-------K-VHQ---HVALKMVRNEKRFHRQ--AA-E----------EIRILEHL--RKQDKDNTMN-----VIHMLENFTF--------------RNHIC--MTFELLSM---NLYELIKK---------------------NKFQ-----------------GF---SLPLVRKFAHSILQCLDALHK--N-----RIIHCDLKPENILLK--QQGRSG------------------IKVIDFGSSC-------------YEHQRVYT---YIQSRFYRAPEV--IL------GARYGMPIDMWSLGCILAELLT-GYPLLP-GE------------DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNG-------------------GRSRRGKLRGPPESREWGNALKGCDDPLFLD-FLKQCLEWDPAVRMT-----PGQALRHPWL-----------
----V-KIEQVIGAGEFGEV---CSGHL---K----LPGK-REI---FVAIKTLK-SGYT-EKQRRD-FL-S-------EASIMGQF--D------HPN-----VIHLEGVVTK--------------STPVM--IITEFMENG--SLDSFLR------------------------QN---------------DGQF---TVIQLVGMLRGIAAGMKYLAD--M-----NYVHRDLAARNILVN--SNLVC--------------------KVSDFGLSRFLE--DDT----S--DPTYTSALGGKIPIRWTAPEA--IQ------YRKFTSASDVWSYGIVMWEVMSYGERPYW-DM------------TNQDVINAIEQDYRLPPPMDCP-----------------------------------------------------------------------------SALHQ-LMLDCWQKDRNHRPK-----FGQIVNTL-------------
----V-KIEEVIGAGEFGEV---CRGRL---K----QPGR-REV---FVAIKTLK-VGYT-ERQRRD-FL-S-------EASIMGQF--D------HPN-----IIRLEGVVTK--------------SRPVM--ILTEFMENC--ALDSFLR------------------------LN---------------DGQF---TVIQLVGMLRGIAAGMKYLSE--M-----NYVHRDLAARNILVN--SNLVC--------------------KVSDFGLSRFLE--DDP----S--DPTYTSSLGGKIPIRWTAPEA--IA------YRKFTSASDVWSYGIVMWEVMSYGERPYW-DM------------SNQDVINAVEQDYRLPPPMDCP-----------------------------------------------------------------------------TALHQ-LMLDCWVRDRNLRPK-----FSQIVNTL-------------
----L-VLGKPLGEGCFGQV---VLAEA---IGLDKDKPN-RVT---KVAVKMLK-SDAT-EKDLSD-LI-S-------EMEMMKMIG-K------HKN-----IINLLGACTQ--------------DGPLY--VIVEYASKG--NLREYLQ------------------------ARRPPGLEYCYNPSHNPEEQL---SSKDLVSCAYQVARGMEYLAS--K-----KCIHRDLAARNVLVT--EDNVM--------------------KIADFGLARDI-----H----H--IDYYKKTTNGRLPVKWMAPEA--LF------DRIYTHQSDVWSFGVLLWEIFTLGGSPYP-GV------------PVEELFKLLKEGHRMDKPSNCT-----------------------------------------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL-------------
-----LTLGKPLGEGCFGQV---VMAEA---VGIDKDKPK-EAV---TVAVKMLK-DDAT-EKDLSD-LV-S-------EMEMMKMIG-K------HKN-----IINLLGACTQ--------------DGPLY--VIVEYASKG--NLREYLR------------------------ARRPPGMEYSYDINRVPEEQM---TFKDLVSCTYQLARGMEYLAS--Q-----KCIHRDLAARNVLVT--ENNVM--------------------KIADFGLARDI-----N----N--IDYYKKTTNGRLPVKWMAPEA--LF------DRVYTHQSDVWSFGVLMWEIFTLGGSPYP-GI------------PVEELFKLLKEGHRMDKPANCT-----------------------------------------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL-------------
-----LQLIKRLGNGQFGEV---WMGTW---N---------GNT---KVAIKTLK-PGTM-SP--ES-FL-E-------EAQIMKKL--K------HDK-----LVQLYAVVS---------------EEPIY--IVTEYMNKG--SLLDFLK------------------------DG--------------EGRAL---KLPNLVDMAAQVAAGMAYIER--M-----NYIHRDLRSANILVG--NGLIC--------------------KIADFGLARLI----------E--DNEYTARQGAKFPIKWTAPEA--AL------YGRFTIKSDVWSFGILLTELVTKGRVPYP-GM------------NNREVLEQVERGYRMPCPQDCP-----------------------------------------------------------------------------ISLHE-LMIHCWKKDPEERPT-----FEYLQSFL-------------
----F-TEFRVLGKGGFGEV---CAVQV---K-------N-TGK---MYACKKLDKKRLKKKG--GE-KMAL------LEKEILEKV--S------SPF-----IVSLAYAFES--------------KTHLC--LVMSLMNGG--DLKFHIYN---------------------VGTR-----------------GL---DMSRVIFYSAQIACGMLHLHE--L-----GIVYRDMKPENVLLD--DLGNC--------------------RLSDLGLAVE-----------MKGGKPITQ---RAGTNGYMAPEI--LM-----EKVSYSYPVDWFAMGCSIYEMVA-GRTPFK-DY-----------KEKVSKEDLKQRTLQDEVKFQHDNF---T-----------------------------------------------------------------------EEAKD-ICRLFLAKKPEQRLG-----SRE-------KSDDPR-----
-----YTDIKVIGNGSFGVV---YQARL---A-------E-TRE---LVAIKKVLQDKRFKNR----------------ELQIMRKL--D------HCN-----IVRLRYFFYSSG----------EKKDELYLNLVLEYVPETVYRVARHFT----------------------KAKL-----------------TI---PILYVKVYMYQLFRSLAYIHS--Q-----GVCHRDIKPQNLLVD-PDTAVL--------------------KLCDFGSAKQ-----------LVRGEPNVS---YICSRYYRAPEL--IF-----GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GD------------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFKSRTPPEAIA-LCSSLLEYTPSSRLS-----PLEACAHSFF-----------
-----YTDTKVIGNGSFGVV---YQAKL---C-------D-SGE---LVAIKKVLQDKRFKNR----------------ELQIMRKL--D------HCN-----IVRLRYFFYSSG----------EKKDEVYLNLVLDYVPETVYRVA---RHY-------------------SRAKQ-----------------TL---PVIYVKLYMYQLFRSLAYIHS--F-----GICHRDIKPQNLLLD-PDTAVL--------------------KLCDFGSAKQ-----------LVRGEPNVS---YICSRYYRAPEL--IF-----GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GD------------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFRPRTPPEAIA-LCSRLLEYTPTARLT-----PLEACAHSFF-----------
-----LKLEKKLGAGQFGEV---WMATY---N---------KHT---KVAVKTMK-PGSM-SV--EA-FL-A-------EANVMKTL--Q------HDK-----LVKLHAVVT---------------KEPIY--IITEFMAKG--SLLDFLK------------------------SD--------------EGSKQ---PLPKLIDFSAQIAEGMAFIEQ--R-----NYIHRDLRAANILVS--ASLVC--------------------KIADFGLARVI----------E--DNEYTAREGAKFPIKWTAPEA--IN------FGSFTIKSDVWSFGILLMEIVTYGRIPYP-GM------------SNPEVIRALERGYRMPRPENCP-----------------------------------------------------------------------------EELYN-IMMRCWKNRPEERPT-----FEYIQSV--L-----------
-----YEVLEFLGRGTFGQV---AKCWK---R-------S-TKE---IVAIKILKNHPSYARQ--GQ-I----------EVSILSRL--S------SENADEYNFVRSYECFQH--------------KNHTC--LVFEMLEQ---NLYDFLKQ---------------------NKFS-----------------PL---PLKYIRPILQQVATALMKLKS--L-----GLIHADLKPENIMLV--DPVRQPY----------------RVKVIDFGSAS------------HVSKAVCST---YLQSRYYRAPEI--IL------GLPFCEAIDMWSLGCVIAELFL-GWPLYP-GA------------SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKE------ARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYID-LLKKMLTIDADKRIT-----PLKTLNHQFV-----------
-----YEVLEFLGRGTFGQV---VKCWK---R-------G-TNE---IVAIKILKNHPSYARQ--GQ-I----------EVSILARL--STE-SADDYN-----FVRAYECFQH--------------KNHTC--LVFEMLEQ---NLYDFLKQ---------------------NKFS-----------------PL---PLKYIRPVLQQVATALMKLKS--L-----GLIHADLKPENIMLV--DPSRQPY----------------RVKVIDFGSAS------------HVSKAVCST---YLQSRYYRAPEI--IL------GLPFCEAIDMWSLGCVIAELFL-GWPLYP-GA------------SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKE------ARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFID-LLKKMLTIDADKRIT-----PIETLNHPFV-----------
-----YEVLDFLGRGTFGQV---VKCWK---R-------G-TNE---IVAIKILKNHPSYARQ--GQ-I----------EVSILARL--S------TENADEYNFVRAYECFQH--------------RNHTC--LVFEMLEQ---NLYDFLKQ---------------------NKFS-----------------PL---PLKVIRPILQQVATALKKLKS--L-----GLIHADLKPENIMLV--DPVRQPY----------------RVKVIDFGSAS------------HVSKTVCST---YLQSRYYRAPEI--IL------GLPFCEAIDMWSLGCVIAELFL-GWPLYP-GA------------LEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKE------ARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVS-LLKKMLLIDADLRIT-----PAETLNHPFV-----------
-----YDIIEVLGKGTFGEV---AKGWR---R-------S-TGE---MVAIKILKNDAYRNRI--IK-N----------ELKLLHCM--RGL-DPEEAH-----VIRFLEFFHD--------------ALKFY--LVFELLEQ---NLFEFQK------------------------EN-----------------NFAPLPARHIRTVTLQVLTALARLKE--L-----AIIHADLKPENIMLV--DQTRCPF----------------RVKVIDFGSASIF----------SEVRYVKEP---YIQSRFYRAPEI--LL------GLPFCEKVDVWSLGCVMAELHL-GWPLYP-GN------------NEYDQVRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVE-LIKRMLTWESHERIS-----PSAALRHPFV-----------
--IGS----RKLGEGSFAKV---REGLH---V-------L-TGE---KVAIKVIDKKRAKKDT--YV-TKNLR-----REGQIQQMI--R------HPN-----ITQLLDILET--------------ENSYY--LVMELCPGG--NLMHKIY-----------------------EKK-----------------RL---EESEARRYIRQLISAVEHLHR--A-----GVVHRDLKIENLLLD--EDNNI--------------------KLIDFGLSNCAG--------ILGYSDPFST---QCGSPAYAAPEL--LA------RKKYGPKIDVWSIGVNMYAMLT-GTLPFT-VE-------------PFSLRALYQKMVD-KEMNPLPTQ--LS-----------------------------------------------------------------------TGAIS-FLRSLLEPDPVKRPN-----IQQALANRWL-----------
-----YTTIRQLGDGTYGSV---LLGRS---I-------E-SGE---LIAIKKMKRKFYSWEE--C--MNLR-------EVKSLKKL--N------HAN-----VVKLKEVIRE--------------NDHLY--FIFEYMKE---NLYQLIK----------------------ERNK-----------------LF---PESAIRNIMYQILQGLAFIHK--H-----GFFHRDLKPENLLCM--GPELV--------------------KIADFGLARE-----------IRSKPPYTD---YVSTRWYRAPEV--LL-----RSTNYSSPIDVWAVGCIMAEVYT-LRPLFP-GA------------SEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCV------------------------------------------------PNNLKTLIPNASSEAVQ-LLRDMLQWDPKKRPT-----ASQALRYPYF-----------
-----YEIDRTIGKGNFAVV---KRATH---L-------V-TKA---KVAIKIIDKTQLDEEN--LK-KIFR-------EVQIMKML--C------HPH-----IIRLYQVMET--------------ERMIY--LVTEYASGG--EIFDHLV-----------------------AHG-----------------RM---AEKEARRKFKQIVTAVYFCHC--R-----NIVHRDLKAENLLLD--ANLNI--------------------KIADFGFSNL-----------FTPGQLLKT---WCGSPPYAAPEL--FE-----GKEYDGPKVDIWSLGVVLYVLVC-GALPFD-GS---------------TLQNLRARVLSGKFRIPFFMS---------------------------------------------------------------------------TECEH-LIRHMLVLDPNKRLS-----MEQICKHKWM-----------
-----LKLVERLGAGQFGEV---WMGYY---N---------GHT---KVAVKSLK-QGSM-SP--DA-FL-A-------EANLMKQL--Q------HQR-----LVRLYAVVT---------------QEPIY--IITEYMENG--SLVDFLK------------------------TP--------------SGIKL---TINKLLDMAAQIAEGMAFIEE--R-----NYIHRDLRAANILVS--DTLSC--------------------KIADFGLARLI----------E--DNEYTAREGAKFPIKWTAPEA--IN------YGTFTIKSDVWSFGILLTEIVTHGRIPYP-GM------------TNPEVIQNLERGYRMVRPDNCP-----------------------------------------------------------------------------EELYQ-LMRLCWKERPEDRPT-----FDYLRSV--L-----------
-----IKLVKRLGAGQFGEV---WMGYY---N---------NST---KVAVKTLK-PGTM-SV--QA-FL-E-------EANLMKTL--Q------HDK-----LVRLYAVVTR--------------EEPIY--IITEYMAKG--SLLDFLK------------------------SD--------------EGGKV---LLPKLIDFSAQIAEGMAYIER--K-----NYIHRDLRAANVLVS--ESLMC--------------------KIADFGLARVI----------E--DNEYTAREGAKFPIKWTAPEA--IN------FGCFTIKSDVWSFGILLYEIVTYGKIPYP-GR------------TNADVMTALSQGYRMPRVENCP-----------------------------------------------------------------------------DELYD-IMKMCWKEKAEERPT-----FDYLQSV--L-----------
-----YTNLSYIGEGAYGMV---CSAYD---N-------V-NKV---RVAIKKISPFEHQTYC--QR-T-LR-------EIKILLRF--R------HEN-----IIGINDIIRAPT---------IEQMKDVY--IVQDLMET---DLYKLLK------------------------TQ-----------------HL---SNDHICYFLYQILRGLKYIHS--A-----NVLHRDLKPSNLLLN--TTCDL--------------------KICDFGLARVAD-------PDHDHTGFLTE---YVATRWYRAPEI--ML-----NSKGYTKSIDIWSVGCILAEMLS-NRPIFP-GK------------HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------------------------------------------KVPWNRLFPNADSKALD-LLDKMLTFNPHKRIE-----VEQALAHPYL-----------
-----YQNLKPIGSGAQGIV---CAAYD---A-------V-LDR---NVAIKKLSRPFQNQTH--AK-RAYR-------ELVLMKCV--N------HKN-----IISLLNVFTPQKT--------LEEFQDVY--LVMELMDA---NLCQVIQ-------------------------M-----------------EL---DHERMSYLLYQMLCGIKHLHS--A-----GIIHRDLKPSNIVVK--SDCTL--------------------KILDFGLART-----------AGTSFMMTP---YVVTRYYRAPEV--IL------GMGYKENVDIWSVGCIMGEMVR-HKILFP-GR------------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK------------------------------------LFPDSLFPADSEHNKLKASQARD-LLSKMLVIDPAKRIS-----VDDALQHPYI-----------
--LQG---LRPVGSGAYGSV---CSAYD---A-------R-LRQ---KVAVKKLSRPFQSLIH--AR-RTYR-------ELRLLKHL--K------HEN-----VIGLLDVFTPATS--------IEDFSEVY--LVTTLMGA---DLNNIVK------------------------CQ-----------------AL---SDEHVQFLVYQLLRGLKYIHS--A-----GIIHRDLKPSNVAVN--EDCEL--------------------RILDFGLAR-------------QADEEMTG---YVATRWYRAPEI--ML-----NWMHYNQTVDIWSVGCIMAELLQ-GKALFP-GS------------DYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-----------------------------------------------QKDLSSIFRGANPLAID-LLGRMLVLDSDQRVS-----AAEALAHAYF-----------
-----YQNLSPVGSGAYGSV---CAAFD---T-------K-TGL---RVAVKKLSRPFQSIIH--AK-RTYR-------ELRLLKHM--K------HEN-----VIGLLDVFTPARS--------LEEFNDVY--LVTHLMGA---DLNNIVK------------------------CQ-----------------KL---TDDHVQFLIYQILRGLKYIHS--A-----DIIHRDLKPSNLAVN--EDCEL--------------------KILDFGLAR-------------HTDDEMTG---YVATRWYRAPEI--ML-----NWMHYNQTVDIWSVGCIMAELLT-GRTLFP-GT------------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------------------------------------------KMNFANVFIGANPLAVD-LLEKMLVLDSDKRIT-----AAQALAHAYF-----------
---YM--DLKPLGCGGNGLV---FSAVD---N-------D-CDK---RVAIKKIVLTDPQSVK--H---ALR-------EIKIIRRL--D------HDN-----IVKVFEILGPSGSQLTDDVGSLTELNSVY--IVQEYMET---DLANVLE------------------------QG-----------------PL---LEEHARLFMYQLLRGLKYIHS--A-----NVLHRDLKPANLFIN-TEDLVL--------------------KIGDFGLARIMD-------PHYSHKGHLSE---GLVTKWYRSPRL--LL-----SPNNYTKAIDMWAAGCIFAEMLT-GKTLFA-GA------------HELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEP------------------------------------------------HKPLTQLLPGISREALD-FLEQILTFSPMDRLT-----AEEALSHPYM-----------
-----YQNLKPIGSGAQGIV---CAAYD---A-------I-LER---NVAIKKLSRPFQNQTH--AK-RAYR-------ELVLMKCV--N------HKN-----IIGLLNVFTPQKS--------LEEFQDVY--IVMELMDA---NLCQVIQ-------------------------M-----------------EL---DHERMSYLLYQMLCGIKHLHS--A-----GIIHRDLKPSNIVVK--SDCTL--------------------KILDFGLART-----------AGTSFMMTP---YVVTRYYRAPEV--IL------GMGYKENVDLWSVGCIMGEMVC-HKILFP-GR------------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK------------------------------------LFPDVLFPADSEHNKLKASQARD-LLSKMLVIDASKRIS-----VDEALQHPYI-----------
-----YQQLKPIGSGAQGIV---CAAFD---T-------V-LGI---NVAVKKLSRPFQNQTH--AK-RAYR-------ELVLLKCV--N------HKN-----IISLLNVFTPQKT--------LEEFQDVY--LVMELMDA---NLCQVIH-------------------------M-----------------EL---DHERMSYLLYQMLCGIKHLHS--A-----GIIHRDLKPSNIVVK--SDCTL--------------------KILDFGLART-----------ACTNFMMTP---YVVTRYYRAPEV--IL------GMGYKENVDIWSVGCIMGELVK-GCVIFQ-GT------------DHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEE------------------------------------LFPDWIFPSESERDKIKTSQARD-LLSKMLVIDPDKRIS-----VDEALRHPYI-----------
-----YRLQKTIGKGNFAKV---KLARH---V-------L-TGR---EVAVKIIDKTQLNPTS--LQ-KLFR-------EVRIMKIL--N------HPN-----IVKLFEVIET--------------EKTLY--LVMEYASGG--EVFDYLV-----------------------AHG-----------------RM---KEKEARAKFRQIVSAVQYCHQ--K-----YIVHRDLKAENLLLD--GDMNI--------------------KIADFGFSNE-----------FTVGNKLDT---FCGSPPYAAPEL--FQ-----GKKYDGPEVDVWSLGVILYTLVS-GSLPFD-GQ---------------NLKELRERVLRGKYRIPFYMS---------------------------------------------------------------------------TDCEN-LLKKLLVLNPIKRGS-----LEQIMKDRWM-----------
-----YRLLKTIGKGNFAKV---KLARH---I-------L-TGK---EVAVKIIDKTQLNSSS--LQ-KLFR-------EVRIMKVL--N------HPN-----IVKLFEVIET--------------EKTLY--LVMEYASGG--EVFDYLV-----------------------AHG-----------------RM---KEKEARAKFRQIVSAVQYCHQ--K-----FIVHRDLKAENLLLD--ADMNI--------------------KIADFGFSNE-----------FTFGNKLDT---FCGSPPYAAPEL--FQ-----GKKYDGPEVDVWSLGVILYTLVS-GSLPFD-GQ---------------NLKELRERVLRGKYRIPFYMS---------------------------------------------------------------------------TDCEN-LLKKFLILNPSKRGT-----LEQIMKDRWM-----------
-----YRLLKTIGKGNFAKV---KLARH---I-------L-TGR---EVAIKIIDKTQLNPTS--LQ-KLFR-------EVRIMKIL--N------HPN-----IVKLFEVIET--------------EKTLY--LIMEYASGG--EVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKV-----------------QV---SFDLLSLMFTFIVSAVQYCHQ--K-----RIVHRDLKAENLLLD--ADMNI--------------------KIADFGFSNE-----------FTVGGKLDT---FCGSPPYAAPEL--FQ-----GKKYDGPEVDVWSLGVILYTLVS-GSLPFD-GQ---------------NLKELRERVLRGKYRIPFYMS---------------------------------------------------------------------------TDCEN-LLKRFLVLNPIKRGT-----LEQIMKDRWI-----------
-----YRLLRTIGKGNFAKV---KLARH---I-------L-TGR---EVAIKIIDKTQLNPSS--LQ-KLFR-------EVRIMKGL--N------HPN-----IVKLFEVIET--------------EKTLY--LVMEYASAG--EVFDYLV-----------------------SHG-----------------RM---KEKEARAKFRQIVSAVHYCHQ--K-----NIVHRDLKAENLLLD--AEANI--------------------KIADFGFSNE-----------FTLGSKLDT---FCGSPPYAAPEL--FQ-----GKKYDGPEVDIWSLGVILYTLVS-GSLPFD-GH---------------NLKELRERVLRGKYRVPFYMS---------------------------------------------------------------------------TDCES-ILRRFLVLNPAKRCT-----LEQIMKDKWI-----------
-----YRIRGEIGSGNFSQV---KLGIH---S-------L-TKE---KVAIKILDKTKLDQKT--QR-LLSR-------EISSMEKL--H------HPN-----IIRLYEVVET--------------LSKLH--LVMEYAGGG--ELFGKIS-----------------------TEG-----------------KL---SEPESKLIFSQIVSAVKHMHE--N-----QIIHRDLKAENVFYT--SNTCV--------------------KVGDFGFSTV-----------SKKGEMLNT---FCGSPPYAAPEL--FR-----DEHYIGIYVDIWALGVLLYFMVT-GTMPFR-AE---------------TVAKLKKSILEGTYSVPPHV----S-----------------------------------------------------------------------EPCHR-LIRGVLQQIPTERYG-----IDCIMNDEWM-----------
-QLQE----DVLGEGAHARV---QTCIN---L-------I-TSQ---EYAVKIIEKQPGHIRS--R---VFR-------EVEMLYQC-QG------HRN-----VLELIEFFEE--------------EDRFY--LVFEKMRGG--SILSHIH-----------------------KRR-----------------HF---NELEASVVVQDVASALDFLHN--K-----GIAHRDLKPENILCE--HPNQVS-----------------PVKICDFDLGSGIKLN---GDCSPISTPELLT---PCGSAEYMAPEV--VEAF-SEEASIYDKRCDLWSLGVILYILLS-GYPPFV-GRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHIS-----------------------------------------------------------------------CAAKD-LISKLLVRDAKQRLS-----AAQVLQHPWV-----------
----Y-VRLQKIGEGSFGKA---ILVKS---T-------E-DGR---QYVIKEINISRMSSKE--RE-ESRR-------EVAVLANM--K------HPN-----IVQYRESFEE--------------NGSLY--IVMDYCEGG--DLFKRINA---------------------QKGV-----------------LF---QEDQILDWFVQICLALKHVHD--R-----KILHRDIKSQNIFLT--KDGTV--------------------QLGDFGIARVL----------NSTVELART---CIGTPYYLSPEI--CE------NKPYNNKSDIWALGCVLYELCT-LKHAFE-AG---------------SMKNLVLKIISGSFPPVSLHYS--------------------------------------------------------------------------YDLRS-LVSQLFKRNPRDRPS-----VNSILEKGF-I----------
-----YEVLYTIGTGSYGRC---QKIRR---K-------S-DGK---ILVWKELDYGSMTEAE--KQ-MLVS-------EVNLLREL--K------HPN-----IVRYYDRIIDR------------TNTTLY--IVMEYCEGG--DLASVITKG-------------------TKERQ-----------------YL---DEEFVLRVMTQLTLALKECHR--RSDGGHTVLHRDLKPANVFLD--GKQNV--------------------KLGDFGLARIL----------NHDTSFAKT---FVGTPYYMSPEQ--MN------RMSYNEKSDIWSLGCLLYELCA-LMPPFT-AF---------------SQKELAGKIREGKFRRIPYRY---S-----------------------------------------------------------------------DELNE-IITRMLNLKDYHRPS-----VEEILENPL-I----------
----Y-MVLRMIGEGSFGRA---LLVQH---E-------S-SNQ---MFAMKEIRLPKSFSNT--QN--SRK-------EAVLLAKM--K------HPN-----IVAFKESFEA--------------EGHLY--IVMEYCDGG--DLMQKIKQ---------------------QKGK-----------------LF---PEDMILNWFTQMCLGVNHIHK--K-----RVLHRDIKSKNIFLT--QNGKV--------------------KLGDFGSARLL----------SNPMAFACT---YVGTPYYVPPEI--WE------NLPYNNKSDIWSLGCILYELCT-LKHPFQ-AN------------SWKNLILKVCQGCISPLPSHYS-----------------------------------------------------------------------------YELQF-LVKQMFKRNPSHRPS-----ATTLLS----RGIV-------
----Y-CYLRVVGKGSYGEV---TLVKH---R-------R-DGK---QYVIKKLNLRNASSRE--RR-AAEQ-------EAQLLSQL--K------HPN-----IVTYKESWEG-------------GDGLLY--IVMGFCEGG--DLYRKLKE---------------------QKGQ-----------------LL---PENQVVEWFVQIAMALQYLHE--K-----HILHRDLKTQNVFLT--RTNII--------------------KVGDLGIARVL----------ENHCDMAST---LIGTPYYMSPEL--FS------NKPYNYKSDVWALGCCVYEMAT-LKHAFN-AK---------------DMNSLVYRIIEGKLPPMPRDY---S-----------------------------------------------------------------------PELAE-LIRTMLSKRPEERPS-----VRSILRQPYI-----------
-----YDVIKAIGQGAFGKA---YLAKG---K-------S-DSK---HCVIKEINFEKMPIQE--KE-ASKK-------EVILLEKM--K------HPN-----IVAFFNSFQE--------------NGRLF--IVMEYCDGG--DLMKRINR---------------------QRGV-----------------LF---SEDQILGWFVQISLGLKHIHD--R-----KILHRDIKAQNIFLS--KNGMV-------------------AKLGDFGIARVL----------NNSMELART---CIGTPYYLSPEI--CQ------NKPYNNKTDIWSLGCVLYELCT-LKHPFE-GN---------------NLQQLVLKICQAHFAPISPGF---S-----------------------------------------------------------------------RELHS-LISQLFQVSPRDRPS-----INSILKRPFL-----------
--YIP---IRVLGRGAFGEA---TLYRR---T-------E-DDS---LVVWKEVDLTRLSEKE--RR-DALN-------EIVILALL--Q------HDN-----IIAYYNHFMD--------------NTTLL--IELEYCNGG--NLYDKILR---------------------QKDK-----------------LF---EEEMVVWYLFQIVSAVSCIHK--A-----GILHRDIKTLNIFLT--KANLI--------------------KLGDYGLAKKL----------NSEYSMAET---LVGTPYYMSPEL--CQ------GVKYNFKSDIWAVGCVIFELLT-LKRTFD-AT---------------NPLNLCVKIVQGIRAMEVDSS-QYS-----------------------------------------------------------------------LELIQ-MVHSCLDQDPEQRPT-----ADELLDRPL-L----------
-----YEFLETLGKGTYGKV---KKARE---S-------S-GR----LVAIKSIRKDKIKDEQ--DL-MHIR------REIEIMSSL--N------HPH-----IIAIHEVFEN--------------SSKIV--IVMEYASRG--DLYDYIS-----------------------ERQ-----------------QL---SEREARHFFRQIVSAVHYCHQ--N-----RVVHRDLKLENILLD--ANGNI--------------------KIADFGLSNL-----------YHQGKFLQT---FCGSPLYASPEI--VN-----GKPYTGPEVDSWSLGVLLYILVH-GTMPFD-GH---------------DHKILVKQISNGAYREPPK-----P-----------------------------------------------------------------------SDACG-LIRWLLMVNPTRRAT-----LEDVASHWW-V----------
-----YELQEVIGSGATAVV---QAAYC---A-------P-KKE---KVAIKRINLEKCQTSM--DE--LLK-------EIQAMSQC--H------HPN-----IVSYYTSFVV--------------KDELW--LVMKLLSGG--SVLDIIKHIVA---------------KGEHKSG-----------------VL---DESTIATILREVLEGLEYLHK--N-----GQIHRDVKAGNILLG--EDGSV--------------------QIADFGVSAFLAT-----GGDITRNKVRKT---FVGTPCWMAPEV--ME-----QVRGYDFKADIWSFGITAIELAT-GAAPYH-KY------------PPMKVLMLTLQNDPPSLETGVQDKE--MLK------------------------------------------------------------------KYGKSFRK-MISLCLQKDPEKRPT-----AAELLRHKFF-----------
----F-KFGKILGEGSFSTV---VLARE---L-------A-TSR---EYAIKILEKRHIIKEN--KVPYVTR-------ERDVMSRL--D------HPF-----FVKLYFTFQD--------------DEKLY--FGLSYAKNG--ELLKYIR-----------------------KIG-----------------SF---DETCTRFYTAEIVSALEYLHG--K-----GIIHRDLKPENILLN--EDMHI--------------------QITDFGTAKVLS--------PESKQARANS---FVGTAQYVSPEL--LT------EKSACKSSDLWALGCIIYQLVA-GLPPFR-AG---------------NEYLIFQKIIKLEYDFPEKFF---------------------------------------------------------------------------PKARD-LVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
-----YEPKEILGRGVSSVV---RRCIH---K-------P-TSQ---EYAVKVIDVTGGGSFS--PE-EVRELREATLKEVDILRKV-SG------HPN-----IIQLKDTYET--------------NTFFF--LVFDLMKRG--ELFDYLT-----------------------EKV-----------------TL---SEKETRKIMRALLEVICTLHK--L-----NIVHRDLKPENILLD--DNMNI--------------------KLTDFGFSCQ-----------LEPGERLRE---VCGTPSYLAPEI--IECSMNEDHPGYGKEVDMWSTGVIMYTLLA-GSPPFW-HR---------------KQMLMLRMIMSGNYQFGSPEWDDYS-----------------------------------------------------------------------DTVKD-LVSRFLVVQPQNRYT-----AEEALAHPFF-----------
--YDP---KDVIGRGVSSVV---RRCVH---R-------A-TGH---EFAVKIMEVTAERLSP--EQ-LEEVREA-TRRETHILRQV-AG------HPH-----IITLIDSYES--------------SSFMF--LVFDLMRKG--ELFDYLT-----------------------EKV-----------------AL---SEKETRSIMRSLLEAVSFLHA--N-----NIVHRDLKPENILLD--DNMQI--------------------RLSDFGFSCH-----------LEPGEKLRE---LCGTPGYLAPEI--LKCSMDETHPGYGKEVDLWACGVILFTLLA-GSPPFW-HR---------------RQILMLRMIMEGQYQFSSPEWDDRS-----------------------------------------------------------------------STVKD-LISRLLQVDPEARLT-----AEQALQHPFF-----------
---PD----EVLGSGQFGIV---YGGKH---R-------K-TGR---DVAIKIIDKLRFPTKQ--ES-QLRN-------EVAILQNL--H------HPG-----VVNLECMFET--------------PERVF--VVMEKLHGD--MLEMILS----------------------SEKG-----------------RL---PEHITKFLITQILVALRHLHF--K-----NIVHCDLKPENVLLA--SADPFP-----------------QVKLCDFGFARI-----------IGEKSFRRS---VVGTPAYLAPEV--LR------NKGYNRSLDMWSVGVIIYVSLS-GTFPFN-ED-----------------EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------------------------------------------HEAID-LINNLLQVKMRKRYS-----VDKTLSHPWL-----------
---PD----EVLGSGQFGVV---YGGKH---R-------K-TGR---DVAVKVIDKLRFPTKQ--ES-QLRN-------EVAILQSL--R------HPG-----IVNLECMFET--------------PEKVF--VVMEKLHGD--MLEMILS----------------------SEKG-----------------RL---PERLTKFLITQILVALRHLHF--K-----NIVHCDLKPENVLLA--SADPFP-----------------QVKLCDFGFARI-----------IGEKSFRRS---VVGTPAYLAPEV--LL------NQGYNRSLDMWSVGVIMYVSLS-GTFPFN-ED-----------------EDINDQIQNAAFMYPASPWSHIS-----------------------------------------------------------------------AGAID-LINNLLQVKMRKRYS-----VDKSLSHPWL-----------
--FAD----EVLGSGQFGIV---YGGKH---R-------K-TGR---DVAIKVIDKMRFPTKQ--ES-QLRN-------EVAILQNL--H------HPG-----IVNLECMFET--------------PERVF--VVMEKLHGD--MLEMILS----------------------SEKS-----------------RL---PERITKFMVTQILVALRNLHF--K-----NIVHCDLKPENVLLA--SAEPFP-----------------QVKLCDFGFARI-----------IGEKSFRRS---VVGTPAYLAPEV--LR------SKGYNRSLDMWSVGVIIYVSLS-GTFPFN-ED-----------------EDINDQIQNAAFMYPPNPWREIS-----------------------------------------------------------------------GEAID-LINNLLQVKMRKRYS-----VDKSLSHPWL-----------
----F-NIIDTLGVGGFGRV---ELVQL---KS------E-ESK---TFAMKILKKRHIVDTR--QQ-EHIR------SEKQIMQGA--H------SDF-----IVRLYRTFKD--------------SKYLY--MLMEACLGG--ELWTILR-----------------------DRG-----------------SF---EDSTTRFYTACVVEAFAYLHS--K-----GIIYRDLKPENLILD--HRGYA--------------------KLVDFGFAKK-----------IGFGKKTWT---FCGTPEYVAPEI--IL------NKGHDISADYWSLGILMYELLT-GSPPFS-GP---------------DPMKTYNIILRGIDMIEFPKKIA-------------------------------------------------------------------------KNAAN-LIKKLCRDNPSERLGNLKNGVKDIQKHKWF-----------
----L-EIIATLGVGGFGRV---ELVKV---K-------N-ENV---AFAMKCIRKKHIVDTK--QQ-EHVY------SEKRILEEL--C------SPF-----IVKLYRTFKD--------------NKYVY--MLLEACLGG--ELWSILR-----------------------DRG-----------------SF---DEPTSKFCVACVTEAFDYLHR--L-----GIIYRDLKPENLILD--AEGYL--------------------KLVDFGFAKK-----------IGSGQKTWT---FCGTPEYVAPEV--IL------NKGHDFSVDFWSLGILVYELLT-GNPPFS-GV---------------DQMMTYNLILKGIEKMDFPRKIT-------------------------------------------------------------------------RRPED-LIRRLCRQNPTERLGNLKNGINDIKKHRWL-----------
---FD--TLATVGTGTFGRV---HLVKE---K-------T-AKH---FFALKVMSIPDVIRLK--QE-QHVH------NEKSVLKEV--S------HPF-----LIRLFWTWHD--------------ERFLY--MLMEYVPGG--ELFSYLR-----------------------NRG-----------------RF---SSTTGLFYSAEIICAIEYLHS--K-----EIVYRDLKPENILLD--RDGHI--------------------KLTDFGFAKK-------------LVDRTWT---LCGTPEYLAPEV--IQ------SKGHGRAVDWWALGILIFEMLS-GFPPFF-DD---------------NPFGIYQKILAGKIDFPRHLD---------------------------------------------------------------------------FHVKD-LIKKLLVVDRTRRLGNMKNGANDVKHHRWF-----------
-YNVY----GYTGQGVFSNV---VRARD---N-------ARANQ---EVAVKIIRNNELMQKT--G----LK-------ELEFLKKL--NDADPDDKFH-----CLRLFRHFYH--------------KQHLC--LVFEPLSM---NLREVLKK--------------------YGKDV-----------------GL---HIKAVRSYSQQLFLALKLLKR--C-----NILHADIKPDNILVN--ESKTI-------------------LKLCDFGSAS------------HVADNDITP---YLVSRFYRAPEI--II------GKSYDYGIDMWSVGCTLYELYT-GKILFP-GK------------TNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVM------------------STINPTKDLLADLIGCQRLPEDQRKKVHQLKD-LLDQILMLDPAKRIS-----INQALQHAFI-----------
----F-TLCRKLGSGYFGEV---FEGLW---K---------DRV---QVAIKVIS-RDNL-LH-QQM-LQ-S-------EIQAMKKL--R------HKH-----ILALYAVVSV--------------GDPVY--IITELMAKG--SLLELLR------------------------DS--------------DEKVL---PVSELLDIAWQVAEGMCYLES--Q-----NYIHRDLAARNILVG--ENTLC--------------------KVGDFGLARLI-------------KEDVYLSHDHNIPYKWTAPEA--LS------RGHYSTKSDVWSFGILLHEMFSRGQVPYP-GM------------SNHEAFLRVDAGYRMPCPLECP-----------------------------------------------------------------------------PSVHK-LMLTCWCRDPEQRPC-----FKALRERL-------------
-----FELLKVLGQGSFGKVFLVRKVTR---P-------D-SGH---LYAMKVLKKATLKVRD--RV-RTKM-------ERDILADV--N------HPF-----VVKLHYAFQT--------------EGKLY--LILDFLRGG--DLFTRLS-----------------------KEV-----------------MF---TEEDVKFYLAELALGLDHLHS--L-----GIIYRDLKPENILLD--EEGHI--------------------KLTDFGLSKEA----------IDHEKKAYS---FCGTVEYMAPEV--VN------RQGHSHSADWWSYGVLMFEMLT-GSLPFQ-GK---------------DRKETMTLILKAKLGMPQFLS---------------------------------------------------------------------------TEAQS-LLRALFKRNPANRLGSGPDGAEEIKRHV--FY---------
-----FELLKVLGQGSYGKV---FLVRK---V-------K-GSDAGQLYAMKVLKKATLKVRD--RV-RSKM-------ERDILAEV--N------HPF-----IVKLHYAFQT--------------EGKLY--LILDFLRGG--DLFTRLS-----------------------KEV-----------------MF---TEEDVKFYLAELALALDHLHS--L-----GIIYRDLKPENILLD--EEGHI--------------------KITDFGLSKEA----------IDHDKRAYS---FCGTIEYMAPEV--VN------RRGHTQSADWWSFGVLMFEMLT-GSLPFQ-GK---------------DRKETMALILKAKLGMPQFLS---------------------------------------------------------------------------GEAQS-LLRALFKRNPCNRLGAGIDGVEEIKRHPFF-----------
-----FELLKVLGQGSFGKV---FLVKK---I-------S-GSDARQLYAMKVLKKATLKVRD--RV-RTKM-------ERDILVEV--N------HPF-----IVKLHYAFQT--------------EGKLY--LILDFLRGG--DLFTRLS-----------------------KEV-----------------MF---TEEDVKFYLAELALALDHLHS--L-----GIIYRDLKPENILLD--EEGHI--------------------KLTDFGLSKES----------IDHEKKAYS---FCGTVEYMAPEV--VN------RRGHTQSADWWSFGVLMFEMLT-GTLPFQ-GK---------------DRKETMTMILKAKLGMPQFLS---------------------------------------------------------------------------PEAQS-LLRMLFKRNPANRLGAGPDGVEEIKRHSFF-----------
-----FELLKVLGQGSFGKV---FLVRK---K-------T-GPDAGQLYAMKVLKKASLKVRD--RV-RTKM-------ERDILVEV--N------HPF-----IVKLHYAFQT--------------EGKLY--LILDFLRGG--DVFTRLS-----------------------KEV-----------------LF---TEEDVKFYLAELALALDHLHQ--L-----GIVYRDLKPENILLD--EIGHI--------------------KLTDFGLSKES----------VDQEKKAYS---FCGTVEYMAPEV--VN------RRGHSQSADWWSYGVLMFEMLT-GTLPFQ-GK---------------DRNETMNMILKAKLGMPQFLS---------------------------------------------------------------------------AEAQS-LLRMLFKRNPANRLGS--EGVEEIKRHLFF-----------
-----FELLRVLGKGGYGKV---FQVRKVTGA-------N-TGK---IFAMKVLKKAMIVRNA--KD-TAHTK-----AERNILEEV--K------HPF-----IVDLIYAFQT--------------GGKLY--LILEYLSGG--ELFMQLE-----------------------REG-----------------IF---MEDTACFYLAEISMALGHLHQ--K-----GIIYRDLKPENIMLN--HQGHV--------------------KLTDFGLCKES----------IHDGTVTHT---FCGTIEYMAPEI--LM------RSGHNRAVDWWSLGALMYDMLT-GAPPFT-GE---------------NRKKTIDKILKCKLNLPPYLT---------------------------------------------------------------------------QEARD-LLKKLLKRNAASRLGAGPGDAGEVQAHPFF-----------
-----YDIERTLGKGNFAVV---KLARH---R-------V-TKT---QVAIKIIDKTRLDSSN--LE-KIYR-------EVQLMKLL--N------HPH-----IIKLYQVMET--------------KDMLY--IVTEFAKNG--EMFDYLT-----------------------SNG-----------------HL---SENEARKKFWQILSAVEYCHD--H-----HIVHRDLKTENLLLD--GNMDI--------------------KLADFGFGNF-----------YKSGEPLST---WCGSPPYAAPEV--FE-----GKEYEGPQLDIWSLGVVLYVLVC-GSLPFD-GP---------------NLPTLRQRVLEGRFRIPFFMS---------------------------------------------------------------------------QDCES-LIRRMLVVDPARRIT-----IAQIRQHRWM-----------
-----YDIEGTLGKGNFAVV---KLGRH---R-------I-TKT---EVAIKIIDKSQLDAVN--LE-KIYR-------EVQIMKML--D------HPH-----IIKLYQVMET--------------KSMLY--LVTEYAKNG--EIFDYLA-----------------------NHG-----------------RL---NESEARRKFWQILSAVDYCHG--R-----KIVHRDLKAENLLLD--NNMNI--------------------KIADFGFGNF-----------FKSGELLAT---WCGSPPYAAPEV--FE-----GQQYEGPQLDIWSMGVVLYVLVC-GALPFD-GP---------------TLPILRQRVLEGRFRIPYFMS---------------------------------------------------------------------------EDCEH-LIRRMLVLDPSKRLT-----IAQIKEHKWM-----------
-----WEIIGELGDGAFGKV---YKAQN---K-------E-TSV---LAAAKVIDTKSEEELE--DY-M--V-------EIDILASC--D------HPN-----IVKLLDAFYY--------------ENNLW--ILIEFCAGG--AVDAVML----------------------ELER-----------------PL---TESQIQVVCKQTLDALNYLHD--N-----KIIHRDLKAGNILFT--LDGDI--------------------KLADFGVSAKN----------TRTIQRRDS---FIGTPYWMAPEV--VMCE-TSKDRPYDYKADVWSLGITLIEMAE-IEPPHH-EL------------NPMRVLLKIAKSEPPTLAQPSRWS---------------------------------------------------------------------------SNFKD-FLKKCLEKNVDARWT-----TSQLLQHPFV-----------
----L-RLEVKLGQGCFGEV---WMGTW---N---------GTT---RVAIKTLK-PGTM-SP--EA-FL-Q-------EAQVMKKL--R------HEK-----LVQLYAVVS---------------EEPIY--IVTEYMSKG--SLLDFLK------------------------GE--------------TGKYL---RLPQLVDMAAQIASGMAYVER--M-----NYVHRDLRAANILVG--ENLVC--------------------KVADFGLARLI----------E--DNEYTARQGAKFPIKWTAPEA--AL------YGRFTIKSDVWSFGILLTELTTKGRVPYP-GM------------VNREVLDQVERGYRMPCPPECP-----------------------------------------------------------------------------ESLHD-LMCQCWRKEPEERPT-----FEYLQAF--L-----------
---FA--LGRKLGEGYFGEV---WEGLW---L---------GSL---PVAIKVIK-SANM-K--LTD-LA-K-------EIQTLKGL--R------HER-----LIRLHAVCSG--------------GEPVY--IVTELMRKG--NLQAFLG------------------------TP--------------EGRAL---RLPPLLGFACQVAEGMSYLEE--Q-----RVVHRDLAARNVLVD--DGLAC--------------------KVADFGLARLL----------K--DDIYSPSSSSKIPVKWTAPEA--AN------YRVFSQKSDVWSFGVLLHEVFTYGQCPYE-GM------------TNHETLQQIMRGYRLPRPAACP-----------------------------------------------------------------------------AEVYV-LMLECWRSSPEERPS-----FATLREKL-------------
-----WEIVGELGDGAFGKV---YKAKN---K-------E-TGA---LAAAKVIETKSEEELE--DY-I--V-------EIEILATC--D------HPY-----IVKLLGAYYH--------------DGKLW--IMIEFCPGG--AVDAIML----------------------ELDR-----------------GL---TEPQIQVVCRQMLEALNFLHS--K-----RIIHRDLKAGNVLMT--LEGDI--------------------RLADFGVSAKN----------LKTLQKRDS---FIGTPYWMAPEV--VMCE-TMKDTPYDYKADIWSLGITLIEMAQ-IEPPHH-EL------------NPMRVLLKIAKSDPPTLLTPSKWS---------------------------------------------------------------------------VEFRD-FLKIALDKNPETRPS-----AAQLLEHPFV-----------
--LCP---GRELGRGKFAVV---RKCIK---K-------D-SGK---EFAAKFMRKRRKGQDC--RM-EIIH-------EIAVLELA-QD------NPW-----VINLHEVYET--------------ASEMI--LVLEYAAGG--EIFDQCVA---------------------DREE-----------------AF---KEKDVQRLMRQILEGVHFLHT--R-----DVVHLDLKPQNILLT--SESPLG-----------------DIKIVDFGLSRI-----------LKNSEELRE---IMGTPEYVAPEI--LS------YDPISMATDMWSIGVLTYVMLT-GISPFL-GN---------------DKQETFLNISQMNLSYSEEEFDVLS-----------------------------------------------------------------------ESAVD-FIRTLLVKKPEDRAT-----AEECLKHPWL-----------
--ILT---SKELGRGKFAVV---RQCIS---K-------S-TGQ---EYAAKFLKKRRRGQDC--RA-EILH-------EIAVLELA-KS------CPR-----VINLHEVYEN--------------TSEII--LILEYAAGG--EIFSLCLP---------------------ELAE-----------------MV---SENDVIRLIKQILEGVYYLHQ--N-----NIVHLDLKPQNILLS--SIYPLG-----------------DIKIVDFGMSRK-----------IGHACELRE---IMGTPEYLAPEI--LN------YDPITTATDMWNIGIIAYMLLT-HTSPFV-GE---------------DNQETYLNISQVNVDYSEETFSSVS-----------------------------------------------------------------------QLATD-FIQSLLVKNPEKRPT-----AEICLSHSWL-----------
-----FTKLEKIGKGSFGEV---FKGID---N-------R-TQK---VVAIKIIDLEEAEDEI--ED-IQ-Q-------EITVLSQC--D------SPY-----VTKYYGSYLK--------------DTKLW--IIMEYLGGG--SALDLLE------------------------PG-----------------PL---DETQIATILREILKGLDYLHS--E-----KKIHRDIKAANVLLS--EHGEV--------------------KLADFGVAGQL----------TDTQIKRNT---FVGTPFWMAPEV--IK------QSAYDSKADIWSLGITAIELAR-GEPPHS-EL------------HPMKVLFLIPKNNPPTLEGNYS-----------------------------------------------------------------------------KPLKE-FVEACLNKEPSFRPT-----AKELLKHKFI-----------
-----FEILRAIGKGSFGKV---CIVQK---N-------D-TKK---MYAMKYMNKQKCVERN--EV-RNVF------KELQIMQGL--E------HPF-----LVNLWYSFQD--------------EEDMF--MVVDLLLGG--DLRYHLQ-----------------------QNV-----------------HF---KEETVKLFICELVMALDYLQN--Q-----RIIHRDMKPDNILLD--EHGHV--------------------HITDFNIAAM-----------LPRETQITT---MAGTKPYMAPEMFSSR-----KGAGYSFAVDWWSLGVTAYELLR-GRRPYH-IR------------SSTSSKEIVHTFETTVVTYPSAWS---------------------------------------------------------------------------QEMVS-LLKKLLEPNPDQRFS----QLSDVQNFPY-M----------
-----YELQEVIGSGATAVV---QAALC---K-------P-RQE---RVAIKRINLEKCQTSM--DE--LLK-------EIQAMSQC--S------HPN-----VVTYYTSFVV--------------KDELW--LVMKLLSGG--SMLDIIKYIVN---------------RGEHKNG-----------------VL---EEAIIATILKEVLEGLDYLHR--N-----GQIHRDLKAGNILLG--EDGSV--------------------QIADFGVSAFLAT-----GGDVTRNKVRKT---FVGTPCWMAPEV--ME-----QVRGYDFKADMWSFGITAIELAT-GAAPYH-KY------------PPMKVLMLTLQNDPPTLETGVEDKE--MMK------------------------------------------------------------------KYGKSFRK-LLSLCLQKDPSKRPT-----AAELLKCKFF-----------
---YL--LLHLLGRGGFSEV---YKAFD---L-------T-EQR---YVAVKIHQLNKNWRDE--KK-ENYHKH--ACREYRIHKEL--D------HPR-----IVKLYDYFSL-------------DTDSFC--TVLEYCEGN--DLDFYLK-----------------------QHK-----------------LM---SEKEARSIIMQIVNALKYLNE--IK---PPIIHYDLKPGNILLV--NGTACG-----------------EIKITDFGLSKIMDDD---SYNSVDGMELTSQ---GAGTYWYLPPEC--FVV--GKEPPKISNKVDVWSVGVIFYQCLY-GRKPFG-HN-------------QSQQDILQENTILKATEVQFPPKPVVT-----------------------------------------------------------------------PEAKA-FIRRCLAYRKEDRID-----VQQLACDPYL-----------
YLLGI-----NLGEGSYAKV---KSAYS---E-------R-LKF---NVAIKIIDRKKAPADF--LE-KFLP------REIEILAML--N------HCS-----IIKTYEIFET-------------SHGKVY--IVMELAVQG--DLLELIK-----------------------TRG-----------------AL---HEDEARKKFHQLSLAIKYCHD--L-----DVVHRDLKCDNLLLD--KDFNI--------------------KLSDFSFSKRCLR------DDSGRMALSKT---FCGSPAYAAPEV--LQ-----GIPYQPKVYDIWSLGVILYIMVC-GSMPYD-DS---------------NIKKMLRIQKEHRVNFPRSKHLT-------------------------------------------------------------------------GECKD-LIYHMLQPDVNRRLH-----IDEILSHCWM-----------
----L-RLEVKLGQGCFGEV---WMGTW---N---------GTT---KVAIKTLK-PGTM-MP--EA-FL-Q-------EAQIMKKL--R------HDK-----LVPLYAVVS---------------EEPIY--IVTEFMSKG--SLLDFLK------------------------EG--------------DGKYL---KLPQLVDMAAQIADGMAYIER--M-----NYIHRDLRAANILVG--ENLVC--------------------KIADFGLARLI----------E--DNEYTARQGAKFPIKWTAPEA--AL------YGRFTIKSDVWSFGILQTELVTKGRVPYP-GM------------VNREVLEQVERGYRMPCPQGCP-----------------------------------------------------------------------------ESLHE-LMNLCWKKDPDERPT-----FEYIQSFL-------------
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