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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FGR 203
TK ABL1 261
TK ABL2 288
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK BLK 241
TKL BMPR1B 204
TKL BRAF 456
TK CSF1R 582
TK CSK 195
TK DDR1 572
TK EPHB6 670
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FRK 234
TK FYN 271
TK HCK 241
TK KDR 834
TK KIT 589
TK LCK 245
TK LYN 247
Other NEK2 8
STE OXSR1 17
TK PDGFRB 600
TK PTK6 191
TKL RAF1 349
TKL RIPK1 17
STE SLK 34
TK SRC 270
TK SRMS 230
Other STK36 4
TK TNK2 150
TK YES1 277
---ITLERRLGTGCFGDVWLGTWN-----------------GSTKVAVKTL-K-P--G-TM-SP--KAFL-E-EAQVMKLL-RHDKLVQLYAVVS------EEPIYIVTEFMCHGSLLDFLK---------NP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERM--------NYIHRDLRAANILVGERLACKIADFGLARLI-----------K--DDEY------NPCQGSKFPIKWTAPEAAL------FGR---FTIKSDVWSFGILLTELITKGR--------------IPYPGM-----NKREVLEQV----EQGYH----MP---CPPGCP-----------ASLYE-AMEQTWRLDPEERPTFEYLQSFL----
---ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTL-K-E--D-TM-EV--EEFL-K-EAAVMKEI-KHPNLVQLLGVCT-R----EPPFYIITEFMTYGNLLDYLR---------EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGENHLVKVADFGLSRLM-----------T--GDTY------TAHAGAKFPIKWTAPESLA------YNK---FSIKSDVWAFGVLLWEIATYGM--------------SPYPGI-----DLSQVYELL----EKDYR----ME---RPEGCP-----------EKVYE-LMRACWQWNPSDRPSFAEIHQA--F--
---ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTL-K-E--D-TM-EV--EEFL-K-EAAVMKEI-KHPNLVQLLGVCT-L----EPPFYIVTEYMPYGNLLDYLR---------EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGENHVVKVADFGLSRLM-----------T--GDTY------TAHAGAKFPIKWTAPESLA------YNT---FSIKSDVWAFGVLLWEIATYGM--------------SPYPGI-----DLSQVYDLL----EKGYR----ME---QPEGCP-----------PKVYE-LMRACWKWSPADRPSFAETHQA--F--
---FEIGRPLGKGKFGNVYLAREK----------------QSKFILALKVL-FKA--QLEKAGV--EHQLRR-EVEIQSHL-RHPNILRLYGYFH-D----ATRVYLILEYAPLGTVYRELQ--------KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK--------RVIHRDIKPENLLLGSAGELKIADFGWSV-------------HAPSSRR------TT---LCGTLDYLPPEMIE------GRM---HDEKVDLWSLGVLCYEFLV-GK--------------PPFEAN--------TYQETY----KRISR----VE---FTFPDFVT---------EGARD-LISRLLKHNPSQRPMLREVLEHPWI--
---FEIGRPLGKGKFGNVYLAREK----------------KSHFIVALKVL-FKS--Q-IEKEG--VEHQLRREIEIQAHL-HHPNILRLYNYFY-D----RRRIYLILEYAPRGELYKELQ--------KSC----------------------------------------------------------------------------------------------------TFDEQRTATIMEELADALMYCHGK--------KVIHRDIKPENLLLGLKGELKIADFGWSV-------------HAPSLRR------KT---MCGTLDYLPPEMIE------GRM---HNEKVDLWCIGVLCYELLV-GN--------------PPFESA--------SHNETY----RRIVK----VD---LKFPASVP---------MGAQD-LISKLLRHNPSERLPLAQVSAHPWV--
---FEIGRPLGKGKFGNVYLARLK----------------ESHFIVALKVL-FKS--Q-IEKEG--LEHQLRREIEIQAHL-QHPNILRLYNYFH-D----ARRVYLILEYAPRGELYKELQ--------KSE----------------------------------------------------------------------------------------------------KLDEQRTATIIEELADALTYCHDK--------KVIHRDIKPENLLLGFRGEVKIADFGWSV-------------HTPSLRR------KT---MCGTLDYLPPEMIE------GRT---YDEKVDLWCIGVLCYELLV-GY--------------PPFESA--------SHSETY----RRILK----VD---VRFPLSMP---------LGARD-LISRLLRYQPLERLPLAQILKHPWV--
--L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAIKTL-K-E--G-TM-SP--EAFL-G-EANVMKAL-QHERLVRLYAVVT------KEPIYIVTEYMARGCLLDFLK---------TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERM--------NSIHRDLRAANILVSEALCCKIADFGLARII--------------DSEY------TAQEGAKFPIKWTAPEAIH------FGV---FTIKADVWSFGVLLMEVVTYGR--------------VPYPGM-----SNPEVIRNL----ERGYR----MP---RPDTCP-----------PELYRGVIAECWRSRPEERPTFEFLQSV--L--
--I-QMVKQIGKGRYGEVWMGKWR----------------GEK--VAVKVF-FTT--E-EASWF--RET----EIYQTVLM-RHENILGFIAADI-KGTGSWTQLYLITDYHENGSLYDYLK---------ST----------------------------------------------------------------------------------------------------TLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFIS-------DTNEVDIPP------NT---RVGTKRYMPPEVLDESLNRNHFQ---SYIMADMYSFGLILWEVAR-RCVSGGIVEEYQLPYHD----LVPSDPSYEDMREIV----CIKKL----RP---SFPNRWSSDECL-----RQMGK-LMTECWAHNPASRLTALRVKK----TL
---ITVGQRIGSGSFGTVYKGKWH-------------------GDVAVKML-N-V-TA-PT-PQQLQAFK-N-EVGVLRKT-RHVNILLFMGYST------KPQLAIVTQWCEGSSLYHHLH---------II--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAK--------SIIHRDLKSNNIFLHEDLTVKIGDFGLATVK-------S---R--WSGS------HQFEQLSGSILWMAPEVIR------MQDKNPYSFQSDVYAFGIVLYELMT-GQ--------------LPYSNI-N---NRDQIIFMV----GRGYLSPDLSK---VRSNCP-----------KAMKR-LMAECLKKKRDERPLFPQILA---SI-
---LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAVKML-K-S--T-AH-ADEKEALM-S-ELKIMSHLGQHENIVNLLGACT-H----GGPVLVITEYCCYGDLLNFLR---------RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASK--------NCIHRDVAARNVLLTNGHVAKIGDFGLARDI-------M---N--DSNY------IVKGNARLPVKWMAPESIF------DCV---YTVQSDVWSYGILLWEIFSLGL--------------NPYPGI-L---VNSKFYKLV----KDGYQ----MA---QPAFAP-----------KNIYS-IMQACWALEPTHRPTFQQICSFL----
---LKLLQTIGKGEFGDVMLGDYR------------------GNKVAVKCI-K-N--D-AT-AQ---AFL-A-EASVMTQL-RHSNLVQLLGVIVEE----KGGLYIVTEYMAKGSLVDYLR---------SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGN--------NFVHRDLAARNVLVSEDNVAKVSDFGLTKEA-----------------S------STQDTGKLPVKWTAPEALR------EKK---FSTKSDVWSFGILLWEIYSFGR--------------VPYPRI-----PLKDVVPRV----EKGYK----MD---APDGCP-----------PAVYE-VMKNCWHLDAAMRPSFLQLREQL----
---LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL-R-P--D-AT-KNARNDFL-K-EVKIMSRL-KDPNIIRLLGVCV-Q----DDPLCMITDYMENGDLNQFLS---------AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATL--------NFVHRDLATRNCLVGENFTIKIADFGMSRNL-------Y---A--GDYY------RVQGRAVLPIRWMAWECIL------MGK---FTTASDVWAFGVTLWEVLMLCRA-------------QPFGQL-----TDEQVIENAGEFFRDQGRQ-VYLS---RPPACP-----------QGLYE-LMLRCWSRESEQRPPFSQLHRFL----
---IKIEEVIGTGSFGEVRQGRLQ-------------PRGRREQTVAIQAL-W-A--G-GA-ESLQMTFL-G-RAAVLGQF-QHPNILRLEGVVT-K----SRPLMVLTEFMELGPLDSFLR---------QR--------------------------------------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSF--------AFVHRSLSAHSVLVNSHLVCKVARLGHSPQG-----------------------------PSCLLRWAAPEVIA------HGK---HTTSSDVWSFGILMWEVMSYGE--------------RPYWDM-----SEQEVLNAI----EQEFR----LP---PPPGCP-----------PGLHL-LMLDTWQKDRARRPHFDQLVA---AF-
--L-VLGEQIGRGNFGEVFSGRLR----------------ADNTLVAVKSC-R-E--T-LP-PDLKAKFL-Q-EARILKQY-SHPNIVRLIGVCT-Q----KQPIYIVMELVQGGDFLTFLR---------TE--------------------------------------------------------------------------------------------------GARLRVKTLLQMVGDAAAGMEYLESK--------CCIHRDLAARNCLVTEKNVLKISDFGMSREE-------A---D--GVYA------ASGGLRQVPVKWTAPEALN------YGR---YSSESDVWSFGILLWETFSLGA--------------SPYPNL-----SNQQTREFV----EKGGR----LP---CPELCP-----------DAVFR-LMEQCWAYEPGQRPSFSTIYQEL----
--L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKML-K-S--D-AT-EKDLSDLI-S-EMEMMKMIGKHKNIINLLGACT-Q----DGPLYVIVEYASKGNLREYLQ---------ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--------KCIHRDLAARNVLVTEDNVMKIADFGLARDI-------H---H--IDYY------KKTTNGRLPVKWMAPEALF------DRI---YTHQSDVWSFGVLLWEIFTLGG--------------SPYPGV-----PVEELFKLL----KEGHR----MD---KPSNCT-----------NELYM-MMRDCWHAVPSQRPTFKQLVEDL----
---LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAVKML-K-D--D-AT-EKDLSDLV-S-EMEMMKMIGKHKNIINLLGACT-Q----DGPLYVIVEYASKGNLREYLR---------ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ--------KCIHRDLAARNVLVTENNVMKIADFGLARDI-------N---N--IDYY------KKTTNGRLPVKWMAPEALF------DRV---YTHQSDVWSFGVLMWEIFTLGG--------------SPYPGI-----PVEELFKLL----KEGHR----MD---KPANCT-----------NELYM-MMRDCWHAVPSQRPTFKQLVEDL----
---IQLLKRLGSGQFGEVWEGLWN-----------------NTTPVAVKTL-K-P--G-SM-DP--NDFL-R-EAQIMKNL-RHPKLIQLYAVCT-L----EDPIYIITELMRHGSLQEYLQ---------ND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESR--------NYIHRDLAARNVLVGEHNIYKVADFGLARVFK-----VD---N--EDIY------ESRHEIKLPVKWTAPEAIR------SNK---FSIKSDVWSFGILLYEIITYGK--------------MPYSGM-----TGAQVIQML----AQNYR----LP---QPSNCP-----------QQFYN-IMLECWNAEPKERPTFETLRWK--L--
---LQLIKRLGNGQFGEVWMGTWN-----------------GNTKVAIKTL-K-P--G-TM-SP--ESFL-E-EAQIMKKL-KHDKLVQLYAVVS------EEPIYIVTEYMNKGSLLDFLK---------DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERM--------NYIHRDLRSANILVGNGLICKIADFGLARLI-----------E--DNEY------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELVTKGR--------------VPYPGM-----NNREVLEQV----ERGYR----MP---CPQDCP-----------ISLHE-LMIHCWKKDPEERPTFEYLQSFL----
---LKLEKKLGAGQFGEVWMATYN-----------------KHTKVAVKTM-K-P--G-SM-SV--EAFL-A-EANVMKTL-QHDKLVKLHAVVT------KEPIYIITEFMAKGSLLDFLK---------SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR--------NYIHRDLRAANILVSASLVCKIADFGLARVI-----------E--DNEY------TAREGAKFPIKWTAPEAIN------FGS---FTIKSDVWSFGILLMEIVTYGR--------------IPYPGM-----SNPEVIRAL----ERGYR----MP---RPENCP-----------EELYN-IMMRCWKNRPEERPTFEYIQSV--L--
---LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAVKML-K-E--G-AT-HSEHRALM-S-ELKILIHIGHHLNVVNLLGACTKP----GGPLMVIVEFCKFGNLSTYLR---------SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASR--------KCIHRDLAARNILLSEKNVVKICDFGLARDI-------Y---K--DPDY------VRKGDARLPLKWMAPETIF------DRV---YTIQSDVWSFGVLLWEIFSLGA--------------SPYPGV-K---IDEEFCRRL----KEGTR----MR---APDYTT-----------PEMYQ-TMLDCWHGEPSQRPTFSELVEHL----
---LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAVKML-K-P--S-AH-LTEREALM-S-ELKVLSYLGNHMNIVNLLGACT-I----GGPTLVITEYCCYGDLLNFLR---------RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK--------NCIHRDLAARNILLTHGRITKICDFGLARDI-------K---N--DSNY------VVKGNARLPVKWMAPESIF------NCV---YTFESDVWSYGIFLWELFSLGS--------------SPYPGM-P---VDSKFYKMI----KEGFR----ML---SPEHAP-----------AEMYD-IMKTCWDADPLKRPTFKQIVQL--I--
---LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSL-K-Q--G-SM-SP--DAFL-A-EANLMKQL-QHQRLVRLYAVVT------QEPIYIITEYMENGSLVDFLK---------TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVSDTLSCKIADFGLARLI-----------E--DNEY------TAREGAKFPIKWTAPEAIN------YGT---FTIKSDVWSFGILLTEIVTHGR--------------IPYPGM-----TNPEVIQNL----ERGYR----MV---RPDNCP-----------EELYQ-LMRLCWKERPEDRPTFDYLRSV--L--
---IKLVKRLGAGQFGEVWMGYYN-----------------NSTKVAVKTL-K-P--G-TM-SV--QAFL-E-EANLMKTL-QHDKLVRLYAVVT-R----EEPIYIITEYMAKGSLLDFLK---------SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERK--------NYIHRDLRAANVLVSESLMCKIADFGLARVI-----------E--DNEY------TAREGAKFPIKWTAPEAIN------FGC---FTIKSDVWSFGILLYEIVTYGK--------------IPYPGR-----TNADVMTAL----SQGYR----MP---RVENCP-----------DELYD-IMKMCWKEKAEERPTFDYLQSV--L--
---YEVLYTIGTGSYGRCQKIRRK----------------SDGKILVWKEL-DYG--S-MTEAE--KQMLVS-EVNLLREL-KHPNIVRYYDRII-DR--TNTTLYIVMEYCEGGDLASVITKG----TKERQ----------------------------------------------------------------------------------------------------YLDEEFVLRVMTQLTLALKECHRRSD---GGHTVLHRDLKPANVFLDGKQNVKLGDFGLARIL-----------NHDTSFA------KT---FVGTPYYMSPEQMN------RMS---YNEKSDIWSLGCLLYELCA-LM--------------PPFTAF--------SQKELA----GKIRE----GK---FRRIPYRY---S-----DELNE-IITRMLNLKDYHRPSVEEILENPL-I-
---YELQEVIGSGATAVVQAAYCA----------------PKKEKVAIKRI-NLE--K-CQTSM--DE-LLK-EIQAMSQC-HHPNIVSYYTSFV-V----KDELWLVMKLLSGGSVLDIIKHIVAKGEHKSG----------------------------------------------------------------------------------------------------VLDESTIATILREVLEGLEYLHKN--------GQIHRDVKAGNILLGEDGSVQIADFGVSAFLAT------GGDITRNKVR------KT---FVGTPCWMAPEVME-----QVRG---YDFKADIWSFGITAIELAT-GA--------------APYHKY-----PPMKVLMLT----LQNDP----PS---LETGVQDKE--MLKKYGKSFRK-MISLCLQKDPEKRPTAAELLRHKFF--
--L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAVKML-K-S--T-AR-SSEKQALM-S-ELKIMSHLGPHLNVVNLLGACT-K----GGPIYIITEYCRYGDLVDYLH---------RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASK--------NCVHRDLAARNVLICEGKLVKICDFGLARDI-------M---R--DSNY------ISKGSTFLPLKWMAPESIF------NSL---YTTLSDVWSFGILLWEIFTLGG--------------TPYPEL-P---MNEQFYNAI----KRGYR----MA---QPAHAS-----------DEIYE-IMQKCWEEKFEIRPPFSQLVL---LL-
--F-TLCRKLGSGYFGEVFEGLWK-----------------DRVQVAIKVI-S-R--D-NL-LH-QQMLQ-S-EIQAMKKL-RHKHILALYAVVS-V----GDPVYIITELMAKGSLLELLR---------DS-------------------------------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQ--------NYIHRDLAARNILVGENTLCKVGDFGLARLI--------------KEDV------YLSHDHNIPYKWTAPEALS------RGH---YSTKSDVWSFGILLHEMFSRGQ--------------VPYPGM-----SNHEAFLRV----DAGYR----MP---CPLECP-----------PSVHK-LMLTCWCRDPEQRPCFKALRERL----
-VM--LSTRIGSGSFGTVYKGKWH-------------------GDVAVKIL-K-V-VD-PT-PEQFQAFR-N-EVAVLRKT-RHVNILLFMGYMT------KDNLAIVTQWCEGSSLYKHLH---------VQ--------------------------------------------------------------------------------------------------ETKFQMFQLIDIARQTAQGMDYLHAK--------NIIHRDMKSNNIFLHEGLTVKIGDFGLATVK-------S---R--WSGS------QQVEQPTGSVLWMAPEVIR------MQDNNPFSFQSDVYSYGIVLYELMT-GE--------------LPYSHI-N---NRDQIIFMV----GRGYASPDLSK---LYKNCP-----------KAMKR-LVADCVKKVKEERPLFPQILSS--I--
LES----AELDSGGFGKVSLCFHR-----------------TQGLMIMKTVYK-G--P-NC-IEHNEALL-E-EAKMMNRL-RHSRVVKLLGVII-E----EGKYSLVMEYMEKGNLMHVLK---------AE---------------------------------------------------------------------------------------------------MSTPLSVKGRIILEIIEGMCYLHGK--------GVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNE-------EHNELREVDGTAKKNGGTLYYMAPEHLN------DVNA-KPTEKSDVYSFAVVLWAIFA-NK--------------EPYENA-I---CEQQLIMCI----KSGNR----PDVDDITEYCP-----------REIIS-LMKLCWEANPEARPTFPGIEEK--F--
---WEIIGELGDGAFGKVYKAQNK----------------ETSVLAAAKVI-DTK--S-EEELE--DYM--V-EIDILASC-DHPNIVKLLDAFY-Y----ENNLWILIEFCAGGAVDAVML-------ELER----------------------------------------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHDN--------KIIHRDLKAGNILFTLDGDIKLADFGVSAKN-----------TRTIQRR------DS---FIGTPYWMAPEVVMCE-TSKDRP---YDYKADVWSLGITLIEMAE-IE--------------PPHHEL-----NPMRVLLKI----AKSEP----PT---LAQPSRWS---------SNFKD-FLKKCLEKNVDARWTTSQLLQHPFV--
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAIKTL-K-P--G-TM-SP--EAFL-Q-EAQVMKKL-RHEKLVQLYAVVS------EEPIYIVTEYMSKGSLLDFLK---------GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVGENLVCKVADFGLARLI-----------E--DNEY------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELTTKGR--------------VPYPGM-----VNREVLDQV----ERGYR----MP---CPPECP-----------ESLHD-LMCQCWRKEPEERPTFEYLQAF--L--
-FA--LGRKLGEGYFGEVWEGLWL-----------------GSLPVAIKVI-K-S--A-NM-K--LTDLA-K-EIQTLKGL-RHERLIRLHAVCS-G----GEPVYIVTELMRKGNLQAFLG---------TP-------------------------------------------------------------------------------------------------EGRALRLPPLLGFACQVAEGMSYLEEQ--------RVVHRDLAARNVLVDDGLACKVADFGLARLL-----------K--DDIY------SPSSSSKIPVKWTAPEAAN------YRV---FSQKSDVWSFGVLLHEVFTYGQ--------------CPYEGM-----TNHETLQQI----MRGYR----LP---RPAACP-----------AEVYV-LMLECWRSSPEERPSFATLREKL----
---YHVLEMIGEGSFGRVYKGRRK----------------YSAQVVALKFI-PKL--G-RSEKE--LRNLQR-EIEIMRGL-RHPNIVHMLDSFE-T----DKEVVVVTDYAEG-ELFQILE--------DDG----------------------------------------------------------------------------------------------------KLPEDQVQAIAAQLVSALYYLHSH--------RILHRDMKPQNILLAKGGGIKLCDFGFARAM-----------STNTMVL------TS---IKGTPLYMSPELVE------ERP---YDHTADLWSVGCILYELAV-GT--------------PPFYAT--------SIFQLV----SLILK----DP---VRWPSTIS---------PCFKN-FLQGLLTKDPRQRLSWPDLLYHPFI--
--L-RLLEKLGDGSFGVVRRGEWD-------------APSGKTVSVAVKCL-K-PDVL-SQ-PEAMDDFI-R-EVNAMHSL-DHRNLIRLYGVVL------TPPMKMVTELAPLGSLLDRLR---------KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK--------RFIHRDLAARNLLLATRDLVKIGDFGLMRAL------PQ---N--DDHY------VMQEHRKVPFAWCAPESLK------TRT---FSHASDTWMFGVTLWEMFTYGQ--------------EPWIGL-----NGSQILHKI---DKEGER----LP---RPEDCP-----------QDIYN-VMVQCWAHKPEDRPTFVALRDF--L--
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAIKTL-K-P--G-TM-MP--EAFL-Q-EAQIMKKL-RHDKLVPLYAVVS------EEPIYIVTEFMSKGSLLDFLK---------EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERM--------NYIHRDLRAANILVGENLVCKIADFGLARLI-----------E--DNEY------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILQTELVTKGR--------------VPYPGM-----VNREVLEQV----ERGYR----MP---CPQGCP-----------ESLHE-LMNLCWKKDPDERPTFEYIQSFL----
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