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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FRK 203
TK ABL1 261
TK ABL2 288
TKL BRAF 456
TK CSF1R 582
TK DDR1 572
TK EPHA3 621
TK EPHA8 635
TK FGFR1 478
TK FGR 263
TK FYN 271
TK INSR 1023
TK JAK2 849
TK KDR 834
TK KIT 589
TK LCK 245
TK LYN 247
TK PDGFRA 593
TK PDGFRB 600
TK SRC 270
TK TEK 824
TK YES1 277
-IQLLKRLGSGQFGEVWEGLWN-----------------NTTPVAVKTLKP-GSMDP--NDFLREAQIMKNL-RHPKLIQLYAVCT--LEDPIYIITELMRHGSLQEYLQND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIY-ESRHEIKLPVKWTAPEAIRSNK---FSIKSDVWSFGILLYEIITYGK-MP---------------YSGM-TGAQVIQML----AQNYR----LPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWK-L--
-ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTLKE-DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT--REPPFYIITEFMTYGNLLDYLREC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM---TGDTY-TAHAGAKFPIKWTAPESLAYNK---FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQVYELL----EKDYR----MERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F--
-ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTLKE-DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT--LEPPFYIVTEYMPYGNLLDYLREC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM---TGDTY-TAHAGAKFPIKWTAPESLAYNT---FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQVYDLL----EKGYR----MEQPEGCPPKVYELMRACWKWSPADRPSFAETHQA-F--
-ITVGQRIGSGSFGTVYKGKWH-------------------GDVAVKMLNVTAPTPQQLQAFKNEVGVLRKT-RHVNILLFMGYST---KPQLAIVTQWCEGSSLYHHLHII--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK--SRWSGS-HQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQ-LP---------------YSNINNRDQIIFMV----GRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA--SI-
-LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAVKMLKS-TAHADEKEALMSELKIMSHLGQHENIVNLLGACT--HGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI--MNDSNY-IVKGNARLPVKWMAPESIFDCV---YTVQSDVWSYGILLWEIFSLGL-NP---------------YPGILVNSKFYKLV----KDGYQ----MAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFL---
-LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRP-DATKNARNDFLKEVKIMSRL-KDPNIIRLLGVCV--QDDPLCMITDYMENGDLNQFLSAHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNL--YAGDYY-RVQGRAVLPIRWMAWECILMGK---FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL-TDEQVIENAGEFFRDQGRQ-VYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL---
I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEISVAIKTLKV-GYTEKQRRDFLGEASIMGQF-DHPNIIRLEGVVT--KSKPVMIVTEYMENGSLDSFLRKH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVL--EDDPEAAYTTRGGKIPIRWTSPEAIAYRK---FTSASDVWSYGIVLWEVMSYGE-RP---------------YWEM-SNQDVIKAV----DEGYR----LPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSIL---
-IHIEKIIGSGDSGEVCYGRLR-------------VPGQRDVPVAIKALKA-GYTERQRRDFLSEASIMGQF-DHPNIIRLEGVVT--RGRLAMIVTEYMENGSLDTFLRTH--------------------------------------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVL--EDDPDAAYTTTGGKIPIRWTAPEAIAFRT---FSSASDVWSFGVVMWEVLAYGE-RP---------------YWNM-TNRDVISSV----EEGYR----LPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVL---
L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKMLKS-DATEKDLSDLISEMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLQARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI--HHIDYY-KKTTNGRLPVKWMAPEALFDRI---YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV-PVEELFKLL----KEGHR----MDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL---
-ITLERRLGTGCFGDVWLGTWN-----------------GSTKVAVKTLKP-GTMSP--KAFLEEAQVMKLL-RHDKLVQLYAVVS---EEPIYIVTEFMCHGSLLDFLKNP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLI---KDDEY-NPCQGSKFPIKWTAPEAALFGR---FTIKSDVWSFGILLTELITKGR-IP---------------YPGM-NKREVLEQV----EQGYH----MPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFL---
-LQLIKRLGNGQFGEVWMGTWN-----------------GNTKVAIKTLKP-GTMSP--ESFLEEAQIMKKL-KHDKLVQLYAVVS---EEPIYIVTEYMNKGSLLDFLKDG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI---EDNEY-TARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILLTELVTKGR-VP---------------YPGM-NNREVLEQV----ERGYR----MPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFL---
-ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAVKTVNE-SASLRERIEFLNEASVMKGF-TCHHVVRLLGVVS--KGQPTLVVMELMAHGDLKSYLRSLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI--YETDYY-RKGGKGLLPVRWMAPESLKDGV---FTTSSDMWSFGVVLWEITSLAE-QP---------------YQGL-SNEQVLKFV----MDGGY----LDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL---
-LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAVKKLQH-STE-EHLRDFEREIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVL-PQDKEYY-KVKEPGESPIFWYAPESLTESK---FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM-IVFHLIELL----KNNGR----LPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLA---LRV
-LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAVKMLKE-GATHSEHRALMSELKILIHIGHHLNVVNLLGACT-KPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI--YKDPDY-VRKGDARLPLKWMAPETIFDRV---YTIQSDVWSFGVLLWEIFSLGA-SP---------------YPGVKIDEEFCRRL----KEGTR----MRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL---
-LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAVKMLKP-SAHLTEREALMSELKVLSYLGNHMNIVNLLGACT--IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI--KNDSNY-VVKGNARLPVKWMAPESIFNCV---YTFESDVWSYGIFLWELFSLGS-SP---------------YPGMPVDSKFYKMI----KEGFR----MLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQL-I--
-LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSLKQ-GSMSP--DAFLAEANLMKQL-QHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLKTP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI---EDNEY-TAREGAKFPIKWTAPEAINYGT---FTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM-TNPEVIQNL----ERGYR----MVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L--
-IKLVKRLGAGQFGEVWMGYYN-----------------NSTKVAVKTLKP-GTMSV--QAFLEEANLMKTL-QHDKLVRLYAVVT--REEPIYIITEYMAKGSLLDFLKSD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVI---EDNEY-TAREGAKFPIKWTAPEAINFGC---FTIKSDVWSFGILLYEIVTYGK-IP---------------YPGR-TNADVMTAL----SQGYR----MPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSV-L--
L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAVKMLKP-TARSSEKQALMSELKIMTHLGPHLNIVNLLGACT--KSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI--MHDSNY-VSKGSTFLPVKWMAPESIFDNL---YTTLSDVWSYGILLWEIFSLGG-TP---------------YPGMMVDSTFYNKI----KSGYR----MAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE--IV-
L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAVKMLKS-TARSSEKQALMSELKIMSHLGPHLNVVNLLGACT--KGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI--MRDSNY-ISKGSTFLPLKWMAPESIFNSL---YTTLSDVWSFGILLWEIFTLGG-TP---------------YPELPMNEQFYNAI----KRGYR----MAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVL--LL-
L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAIKTLKP-GTMSP--EAFLQEAQVMKKL-RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKGE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI---EDNEY-TARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM-VNREVLDQV----ERGYR----MPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF-L--
-IKFQDVIGEGNFGQVLKARIK--------------KDGLRMDAAIKRMKE-YASKDDHRDFAGELEVLCKLGHHPNIINLLGACE--HRGYLYLAIEYAPHGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ-----EVY-VKKTMGRLPVRWMAIESLNYSV---YTTNSDVWSYGVLLWEIVSLGG-TP---------------YCGM-TCAELYEKL----PQGYR----LEKPLNCDDEVYDLMRQCWREKPYERPSFAQILV--SL-
L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAIKTLKP-GTMMP--EAFLQEAQIMKKL-RHDKLVPLYAVVS---EEPIYIVTEFMSKGSLLDFLKEG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLI---EDNEY-TARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM-VNREVLEQV----ERGYR----MPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFL---
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