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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FRK 203
TK ABL1 261
TK ABL2 288
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK BLK 241
TK BMX 422
CAMK BRSK1 50
CAMK BRSK2 19
CAMK CAMK2A 13
CAMK CAMK2D 14
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK9 2.7.11.23
CAMK CHEK2 220
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CMGC DYRK1A 150
Other EIF2AK2 267
TK FGFR1 478
TK FGR 263
TK FYN 271
CMGC GSK3A 119
CMGC GSK3B 56
TK HCK 241
TK ITK 363
TK LCK 245
TK LYN 247
TKL MAP3K11 117
TKL MAP3K9 144
CMGC NLK 126
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
AGC PDPK1 82
CAMK PHKG1 20
CAMK PIM1 38
CAMK PIM2 132
CAMK PIM3 40
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA6 73
CAMK SIK2 20
TK SRC 270
CAMK STK17A 61
TK TNK2 150
TK YES1 277
---IQLLKRLGSGQFGEV---WEGLWN--------NTT---PVAVKTLK-P--G-SM-DP-----ND-FL-R-------EAQIMKNL--R----HPK-----LIQLYAVCTL-----------------------------EDPIY--IITEL-MRHG--SLQEYLQ-----ND--------------TGSKI---HLTQQVDMAAQVASGMAYLES--R---N---YIHRDLAARNVLVG--E--------HNIY--------KVADFGLARVFK-VD--N--EDIY--------------ESRHEIKLPVKWTAPEAIR------SNKFSIKSDVWSFGILLYEIITYGK-MPYS-GMTGAQVIQML-AQNYRLPQPSNCP---------------------------------------------------------------QQFYN-IMLECWNAEPKERPT-----FETLRWK--L-----------
---ITMKHKLGGGQYGEV---YEGVWK-------KYSL---TVAVKTLK-E--D-TM-EV-----EE-FL-K-------EAAVMKEI--K----HPN-----LVQLLGVCTR-----------------------------EPPFY--IITEF-MTYG--NLLDYLR-----EC--------------NRQEV---NAVVLLYMATQISSAMEYLEK--K---N---FIHRDLAARNCLVG--E--------NHLV--------KVADFGLSRLM------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNKFSIKSDVWAFGVLLWEIATYGM-SPYP-GIDLSQVYELL-EKDYRMERPEGCP---------------------------------------------------------------EKVYE-LMRACWQWNPSDRPS-----FAEIHQA--F-----------
---ITMKHKLGGGQYGEV---YVGVWK-------KYSL---TVAVKTLK-E--D-TM-EV-----EE-FL-K-------EAAVMKEI--K----HPN-----LVQLLGVCTL-----------------------------EPPFY--IVTEY-MPYG--NLLDYLR-----EC--------------NREEV---TAVVLLYMATQISSAMEYLEK--K---N---FIHRDLAARNCLVG--E--------NHVV--------KVADFGLSRLM------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNTFSIKSDVWAFGVLLWEIATYGM-SPYP-GIDLSQVYDLL-EKGYRMEQPEGCP---------------------------------------------------------------PKVYE-LMRACWKWSPADRPS-----FAETHQA--F-----------
---FEIGRPLGKGKFGNV---YLAREK-------QSKF---ILALKVLFKA--QLEKAGV-----EH-QLRR-------EVEIQSHL--R----HPN-----ILRLYGYFHD-----------------------------ATRVY--LILEY-APLG--TVYRELQ----KLS-----------------KF---DEQRTATYITELANALSYCHS--K---R---VIHRDIKPENLLLG--S--------AGEL--------KIADFGWSV--------HAPSSRR--------------TT---LCGTLDYLPPEMIE------GRMHDEKVDLWSLGVLCYEFLV-GK-PPFE-AN---TYQETY-KRISRVEFTFPDFVT-------------------------------------------------------------EGARD-LISRLLKHNPSQRPM-----LREVLEHPWI-----------
---FEIGRPLGKGKFGNV---YLAREK-------KSHF---IVALKVLFKS--Q-IEKEG-----VE-HQLR------REIEIQAHL--H----HPN-----ILRLYNYFYD-----------------------------RRRIY--LILEY-APRG--ELYKELQ----KSC-----------------TF---DEQRTATIMEELADALMYCHG--K---K---VIHRDIKPENLLLG--L--------KGEL--------KIADFGWSV--------HAPSLRR--------------KT---MCGTLDYLPPEMIE------GRMHNEKVDLWCIGVLCYELLV-GN-PPFE-SA---SHNETY-RRIVKVDLKFPASVP-------------------------------------------------------------MGAQD-LISKLLRHNPSERLP-----LAQVSAHPWV-----------
---FEIGRPLGKGKFGNV---YLARLK-------ESHF---IVALKVLFKS--Q-IEKEG-----LE-HQLR------REIEIQAHL--Q----HPN-----ILRLYNYFHD-----------------------------ARRVY--LILEY-APRG--ELYKELQ----KSE-----------------KL---DEQRTATIIEELADALTYCHD--K---K---VIHRDIKPENLLLG--F--------RGEV--------KIADFGWSV--------HTPSLRR--------------KT---MCGTLDYLPPEMIE------GRTYDEKVDLWCIGVLCYELLV-GY-PPFE-SA---SHSETY-RRILKVDVRFPLSMP-------------------------------------------------------------LGARD-LISRLLRYQPLERLP-----LAQILKHPWV-----------
--L-RLVRKLGSGQFGEV---WMGYYK--------NNM---KVAIKTLK-E--G-TM-SP-----EA-FL-G-------EANVMKAL--Q----HER-----LVRLYAVVT------------------------------KEPIY--IVTEY-MARG--CLLDFLK-----TD--------------EGSRL---SLPRLIDMSAQIAEGMAYIER--M---N---SIHRDLRAANILVS--E--------ALCC--------KIADFGLARII---------DSEY--------------TAQEGAKFPIKWTAPEAIH------FGVFTIKADVWSFGVLLMEVVTYGR-VPYP-GMSNPEVIRNL-ERGYRMPRPDTCP---------------------------------------------------------------PELYRGVIAECWRSRPEERPT-----FEFLQSV--L-----------
---ITLLKELGSGQFGVV---QLGKWK--------GQY---DVAVKMIK-E--G-SM-SE-----DE-FF-Q-------EAQTMMKL--S----HPK-----LVKFYGVCSK-----------------------------EYPIY--IVTEY-ISNG--CLLNYLR-----SH---------------GKGL---EPSQLLEMCYDVCEGMAFLES--H---Q---FIHRDLAARNCLVD--R--------DLCV--------KVSDFGMTRYV------L--DDQY--------------VSSVGTKFPVKWSAPEVFH------YFKYSSKSDVWAFGILMWEVFSLGK-QPYD-LYDNSQVVLKV-SQGHRLYRPHLAS---------------------------------------------------------------DTIYQ-IMYSCWHELPEKRPT-----FQQLLSS--I-----------
---YRLEKTLGKGQTGLV---KLGVHC-------ITGQ---KVAIKIVNRE--K-LSESV-----LM-KVER-------EIAILKLI--E----HPH-----VLKLHDVYEN-----------------------------KKYLY--LVLEH-VSGG--ELFDYLV----KKG-----------------RL---TPKEARKFFRQIVSALDFCHS--Y---S---ICHRDLKPENLLLD--E--------KNNI--------RIADFGMASL-------QVGDSLL--------------ET---SCGSPHYACPEVIK-----GEKYDGRRADMWSCGVILFALLV-GA-LPFD-DD---NLRQLL-EKVKRGVFHMPHFIP-------------------------------------------------------------PDCQS-LLRGMIEVEPEKRLS-----LEQIQKHPW-Y----------
---YRLEKTLGKGQTGLV---KLGVHC-------VTCQ---KVAIKIVNRE--K-LSESV-----LM-KVER-------EIAILKLI--E----HPH-----VLKLHDVYEN-----------------------------KKYLY--LVLEH-VSGG--ELFDYLV----KKG-----------------RL---TPKEARKFFRQIISALDFCHS--H---S---ICHRDLKPENLLLD--E--------KNNI--------RIADFGMASL-------QVGDSLL--------------ET---SCGSPHYACPEVIR-----GEKYDGRKADVWSCGVILFALLV-GA-LPFD-DD---NLRQLL-EKVKRGVFHMPHFIP-------------------------------------------------------------PDCQS-LLRGMIEVDAARRLT-----LEHIQKHIW-Y----------
---YQLFEELGKGAFSVV---RRCVKV-------LAGQ---EYAAKIINTK--K-LSARD-----HQ-KLER-------EARICRLL--K----HPN-----IVRLHDSISE-----------------------------EGHHY--LIFDL-VTGG--ELFEDIV----ARE-----------------YY---SEADASHCIQQILEAVLHCHQ--M---G---VVHRDLKPENLLLA--S--------KLKGA-----AVKLADFGLAIEV------EGEQQAW--------------FG---FAGTPGYLSPEVLR------KDPYGKPVDLWACGVILYILLV-GY-PPFW-DE---DQHRLY-QQIKAGAYDFPSPEWDTVT---------------------------------------------------------PEAKD-LINKMLTINPSKRIT-----AAEALKHPWI-----------
---YQLFEELGKGAFSVV---RRCMKI-------PTGQ---EYAAKIINTK--K-LSARD-----HQ-KLER-------EARICRLL--K----HPN-----IVRLHDSISE-----------------------------EGFHY--LVFDL-VTGG--ELFEDIV----ARE-----------------YY---SEADASHCIQQILESVNHCHL--N---G---IVHRDLKPENLLLA--S--------KSKGA-----AVKLADFGLAIEV------QGDQQAW--------------FG---FAGTPGYLSPEVLR------KDPYGKPVDMWACGVILYILLV-GY-PPFW-DE---DQHRLY-QQIKAGAYDFPSPEWDTVT---------------------------------------------------------PEAKD-LINKMLTINPAKRIT-----ASEALKHPWI-----------
---YTKIEKIGEGTYGVV---YKGRHK-------TTGQ---VVAMKKIRLE--S-EEEGV-----PS-TAIR-------EISLLKEL--R----HPN-----IVSLQDVLMQ-----------------------------DSRLY--LIFEF-LSM---DLKKYLDS-IPPGQ-----------------YM---DSSLVKSYLYQILQGIVFCHS--R---R---VLHRDLKPQNLLID--D--------KGTI--------KLADFGLARAF------GIPIRVY--------------TH---EVVTLWYRSPEVLL-----GSARYSTPVDIWSIGTIFAELAT-KK-PLFH-GDSEIDQLFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-----GKMALNHPYF-----------
---FQKVEKIGEGTYGVV---YKARNK-------LTGE---VVALKKIRLD--T-ETEGV-----PS-TAIR-------EISLLKEL--N----HPN-----IVKLLDVIHT-----------------------------ENKLY--LVFEF-LHQ---DLKKFMDA--SALT-----------------GI---PLPLIKSYLFQLLQGLAFCHS--H---R---VLHRDLKPQNLLIN--T--------EGAI--------KLADFGLARAF------GVPVRTY--------------TH---EVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RR-ALFP-GDSEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-----AKAALAHPFF-----------
---FQKVEKIGEGTYGVV---YKAKNR-------ETGQ---LVALKKIRLD--L-EMEGV-----PS-TAIR-------EISLLKEL--K----HPN-----IVRLLDVVHN-----------------------------ERKLY--LVFEF-LSQ---DLKKYMDS--TPGS-----------------EL---PLHLIKSYLFQLLQGVSFCHS--H---R---VIHRDLKPQNLLIN--E--------LGAI--------KLADFGLARAF------GVPLRTY--------------TH---EVVTLWYRAPEILL-----GSKFYTTAVDIWSIGCIFAEMVT-RK-ALFP-GDSEIDQLFRI-FRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-----------------------------------KGLEEIVPNLEPEGRD-LLMQLLQYDPSQRIT-----AKTALAHPYF-----------
---YEKLEKIGEGTYGTV---FKAKNR-------ETHE---IVALKRVRLD--D-DDEGV-----PS-SALR-------EICLLKEL--K----HKN-----IVRLHDVLHS-----------------------------DKKLT--LVFEF-CDQ---DLKKYFD---SCNG-----------------DL---DPEIVKSFLFQLLKGLGFCHS--R---N---VLHRDLKPQNLLIN--R--------NGEL--------KLADFGLARAF------GIPVRCY--------------SA---EVVTLWYRPPDVLF-----GAKLYSTSIDMWSAGCIFAELANAGR-PLFP-GNDVDDQLKRI-FRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-----------------------------------TSLVNVVPKLNATGRD-LLQNLLKCNPVQRIS-----AEEALQHPYF-----------
---YECVAEIGEGAYGKV---FKARDL-------KNGG--RFVALKRVRVQ--T-GEEGM-----PL-STIR-------EVAVLRHL--ET-FEHPN-----VVRLFDVCTVSR------------------------TDRETKLT--LVFEH-VDQ---DLTTYLDK--VPEP-----------------GV---PTETIKDMMFQLLRGLDFLHS--H---R---VVHRDLKPQNILVT--S--------SGQI--------KLADFGLARI-------YSFQMAL--------------TS---VVVTLWYRAPEVLL------QSSYATPVDLWSVGCIFAEMFR-RK-PLFR-GSSDVDQLGKI-LDVIGLPGEEDWPRDVALPRQAFHSKSAQ-------------------------------------PIEKFVTDIDELGKD-LLLKCLTFNPAKRIS-----AYSALSHPYF-----------
---YEKLAKIGQGTFGEV---FKARHR-------KTGQ---KVALKKVLME--N-EKEGF-----PI-TALR-------EIKILQLL--K----HEN-----VVNLIEICRTKASP---------------------YNRCKGSIY--LVFDF-CEH---DLAGLLS---NVLV-----------------KF---TLSEIKRVMQMLLNGLYYIHR--N---K---ILHRDMKAANVLIT--R--------DGVL--------KLADFGLARAFSL--AKNSQPNRY--------------TN---RVVTLWYRPPELLL-----GERDYGPPIDLWGAGCIMAEMWT-RS-PIMQ-GNTEQHQLALI-SQLCGSITPEVWPNVDNYELYEKLELVKGQK--------------------------------RKVKDRLKAYVRDPYALD-LIDKLLVLDPAQRID-----SDDALNHDFF-----------
-YI--MSKTLGSGACGEV---KLAFER-------KTCK---KVAIKIISKR--K-FAIGS-----AR-EADPALN-VETEIEILKKL--N----HPC-----IIKIKNFF-D-----------------------------AEDYY--IVLEL-MEGG--ELFDKVV----GNK-----------------RL---KEATCKLYFYQMLLAVQYLHE--N---G---IIHRDLKPENVLLS--S--------QEEDC-----LIKITDFGHSKI-------LGETSLM--------------RT---LCGTPTYLAPEVLVS---VGTAGYNRAVDCWSLGVILFICLS-GY-PPFS-EH--RTQVSLK-DQITSGKYNFIPEVWAEVS---------------------------------------------------------EKALD-LVKKLLVVDPKARFT-----TEEALRHPWL-----------
---YQLVRKLGRGKYSEV---FEAINI-------TNNE---KVVVKILKPV--K-KKKIK-----R-------------EIKILENL-RG----GPN-----IITLADIVKDP---------------------------VSRTPA--LVFEH-VNNT--DFKQLY-------Q-----------------TL---TDYDIRFYMYEILKALDYCHS--M---G---IMHRDVKPHNVMID-HE--------HRKL--------RLIDWGLAEF-------YHPGQEY--------------NV---RVASRYFKGPELLV-----DYQMYDYSLDMWSLGCMLASMIF-RK-EPFFHGHDNYDQLVRI-AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK---------------------------RWERFVHSENQHLVSPEALD-FLDKLLRYDHQSRLT-----AREAMEHPYF-----------
---YQLVRKLGRGKYSEV---FEAINI-------TNNE---RVVVKILKPV--K-KKKIK-----R-------------EVKILENL-RG----GTN-----IIKLIDTVKDP---------------------------VSKTPA--LVFEY-INNT--DFKQLY-------Q-----------------IL---TDFDIRFYMYELLKALDYCHS--K---G---IMHRDVKPHNVMID-HQ--------QKKL--------RLIDWGLAEF-------YHPAQEY--------------NV---RVASRYFKGPELLV-----DYQMYDYSLDMWSLGCMLASMIF-RR-EPFFHGQDNYDQLVRI-AKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRK---------------------------RWENFIHSENRHLVSPEALD-LLDKLLRYDHQQRLT-----AKEAMEHPYF-----------
---YEIDSLIGKGSFGQV---VKAYDR-------VEQE---WVAIKIIKNK--K-AFLNQ-----AQ-I----------EVRLLELM-NK----HDTEMKYYIVHLKRHFMF-----------------------------RNHLC--LVFEM-LSY---NLYDLLR-----NT-----------------NFRGVSLNLTRKFAQQMCTALLFLATPEL---S---IIHCDLKPENILLCNPK--------RSAI--------KIVDFGSSCQ---------LGQRI--------------YQ---YIQSRFYRSPEVLL------GMPYDLAIDMWSLGCILVEMHT-GE-PLFS-GANEVDQMNKI-VEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKD-LILRMLDYDPKTRIQ-----PYYALQHSFF-----------
--F-KEIELIGSGGFGQV---FKAKHR-------IDGK---TYVIKRVKYN--N-EKAER-------------------EVKALAKL--D----HVN-----IVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEF-CDKG--TLEQWIEK--RRGE-----------------KL---DKVLALELFEQITKGVDYIHS--K---K---LIHRDLKPSNIFLV--D--------TKQV--------KIGDFGLVTS-------LKNDGKR--------------TR---SKGTLRYMSPEQIS------SQDYGKEVDLYALGLILAELLH-VCDTAFE-T-------SKF-FTDLRDGIISDIFDK--------------------------------------------------------------KEKT-LLQKLLSKKPEDRPN-----TSEILR----TLT--------
--L-VLGKPLGEGCFGQV---VLAEAIGLDKDKPNRVT---KVAVKMLK-S--D-AT-EKD---LSD-LI-S-------EMEMMKMIG-K----HKN-----IINLLGACTQ-----------------------------DGPLY--VIVEY-ASKG--NLREYLQ-----ARRPPGLEYCYNPSHNPEEQL---SSKDLVSCAYQVARGMEYLAS--K---K---CIHRDLAARNVLVT--E--------DNVM--------KIADFGLARDI---H--H--IDYY--------------KKTTNGRLPVKWMAPEALF------DRIYTHQSDVWSFGVLLWEIFTLGG-SPYP-GVPVEELFKLL-KEGHRMDKPSNCT---------------------------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL-------------
---ITLERRLGTGCFGDV---WLGTWN--------GST---KVAVKTLK-P--G-TM-SP-----KA-FL-E-------EAQVMKLL--R----HDK-----LVQLYAVVS------------------------------EEPIY--IVTEF-MCHG--SLLDFLK-----NP--------------EGQDL---RLPQLVDMAAQVAEGMAYMER--M---N---YIHRDLRAANILVG--E--------RLAC--------KIADFGLARLI------K--DDEY--------------NPCQGSKFPIKWTAPEAAL------FGRFTIKSDVWSFGILLTELITKGR-IPYP-GMNKREVLEQV-EQGYHMPCPPGCP---------------------------------------------------------------ASLYE-AMEQTWRLDPEERPT-----FEYLQSFL-------------
---LQLIKRLGNGQFGEV---WMGTWN--------GNT---KVAIKTLK-P--G-TM-SP-----ES-FL-E-------EAQIMKKL--K----HDK-----LVQLYAVVS------------------------------EEPIY--IVTEY-MNKG--SLLDFLK-----DG--------------EGRAL---KLPNLVDMAAQVAAGMAYIER--M---N---YIHRDLRSANILVG--N--------GLIC--------KIADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELVTKGR-VPYP-GMNNREVLEQV-ERGYRMPCPQDCP---------------------------------------------------------------ISLHE-LMIHCWKKDPEERPT-----FEYLQSFL-------------
---YTDIKVIGNGSFGVV---YQARLA-------ETRE---LVAIKKVLQD--K-RFKNR-------------------ELQIMRKL--D----HCN-----IVRLRYFFYSSG-------------------------EKKDELYLNLVLEY-VPETVYRVARHFT---KAKL-----------------TI---PILYVKVYMYQLFRSLAYIHS--Q---G---VCHRDIKPQNLLVD-PD--------TAVL--------KLCDFGSAKQ-------LVRGEPN--------------VS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQ-PIFP-GDSGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFKSRTPPEAIA-LCSSLLEYTPSSRLS-----PLEACAHSFF-----------
---YTDTKVIGNGSFGVV---YQAKLC-------DSGE---LVAIKKVLQD--K-RFKNR-------------------ELQIMRKL--D----HCN-----IVRLRYFFYSSG-------------------------EKKDEVYLNLVLDY-VPETVYRVA---RHYSRAKQ-----------------TL---PVIYVKLYMYQLFRSLAYIHS--F---G---ICHRDIKPQNLLLD-PD--------TAVL--------KLCDFGSAKQ-------LVRGEPN--------------VS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQ-PIFP-GDSGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIA-LCSRLLEYTPTARLT-----PLEACAHSFF-----------
---LKLEKKLGAGQFGEV---WMATYN--------KHT---KVAVKTMK-P--G-SM-SV-----EA-FL-A-------EANVMKTL--Q----HDK-----LVKLHAVVT------------------------------KEPIY--IITEF-MAKG--SLLDFLK-----SD--------------EGSKQ---PLPKLIDFSAQIAEGMAFIEQ--R---N---YIHRDLRAANILVS--A--------SLVC--------KIADFGLARVI------E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGSFTIKSDVWSFGILLMEIVTYGR-IPYP-GMSNPEVIRAL-ERGYRMPRPENCP---------------------------------------------------------------EELYN-IMMRCWKNRPEERPT-----FEYIQSV--L-----------
---LTFVQEIGSGQFGLV---HLGYWL--------NKD---KVAIKTIR-E--G-AM-SE-----ED-FI-E-------EAEVMMKL--S----HPK-----LVQLYGVCLE-----------------------------QAPIC--LVFEF-MEHG--CLSDYLR-----TQ---------------RGLF---AAETLLGMCLDVCEGMAYLEE--A---C---VIHRDLAARNCLVG--E--------NQVI--------KVSDFGMTRFV------L--DDQY--------------TSSTGTKFPVKWASPEVFS------FSRYSSKSDVWSFGVLMWEVFSEGK-IPYE-NRSNSEVVEDI-STGFRLYKPRLAS---------------------------------------------------------------THVYQ-IMNHCWKERPEDRPA-----FSRLLRQL-------------
---LKLVERLGAGQFGEV---WMGYYN--------GHT---KVAVKSLK-Q--G-SM-SP-----DA-FL-A-------EANLMKQL--Q----HQR-----LVRLYAVVT------------------------------QEPIY--IITEY-MENG--SLVDFLK-----TP--------------SGIKL---TINKLLDMAAQIAEGMAFIEE--R---N---YIHRDLRAANILVS--D--------TLSC--------KIADFGLARLI------E--DNEY--------------TAREGAKFPIKWTAPEAIN------YGTFTIKSDVWSFGILLTEIVTHGR-IPYP-GMTNPEVIQNL-ERGYRMVRPDNCP---------------------------------------------------------------EELYQ-LMRLCWKERPEDRPT-----FDYLRSV--L-----------
---IKLVKRLGAGQFGEV---WMGYYN--------NST---KVAVKTLK-P--G-TM-SV-----QA-FL-E-------EANLMKTL--Q----HDK-----LVRLYAVVTR-----------------------------EEPIY--IITEY-MAKG--SLLDFLK-----SD--------------EGGKV---LLPKLIDFSAQIAEGMAYIER--K---N---YIHRDLRAANVLVS--E--------SLMC--------KIADFGLARVI------E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGCFTIKSDVWSFGILLYEIVTYGK-IPYP-GRTNADVMTAL-SQGYRMPRVENCP---------------------------------------------------------------DELYD-IMKMCWKEKAEERPT-----FDYLQSV--L-----------
---LRLEEVIGIGGFGKV---YRGSWR---------GE---LVAVKAAR-Q--D-PD-EDISVTAES-VR-Q-------EARLFAML--A----HPN-----IIALKAVCLE-----------------------------EPNLC--LVMEY-AAGG--PLSRALA-----GR-----------------RV---PPHVLVNWAVQIARGMHYLHC--E---ALVPVIHRDLKSNNILLL--QPIESDDMEHKTL--------KITDFGLAREW-----------HK--------------TTQMSAAGTYAWMAPEVIK------ASTFSKGSDVWSFGVLLWELLT-GE-VPYR-GIDCLAVAYGVAVNKLTLPIPSTCP---------------------------------------------------------------EPFAQ-LMADCWAQDPHRRPD-----FASILQQL-------------
--L-TLEEIIGIGGFGKV---YRAFWI-------GDE-----VAVKAARHDP-D-EDISQ-----TI-ENVR------QEAKLFAML--K----HPN-----IIALRGVCLK-----------------------------EPNLC--LVMEF-ARGG--PLNRVLS-----GK-----------------RI---PPDILVNWAVQIARGMNYLHD--EAIVP---IIHRDLKSSNILIL--Q--------KVENGDLSNKILKITDFGLAR--------EWHRTTK--------------MS---AAGTYAWMAPEVIR------ASMFSKGSDVWSYGVLLWELLT-GE-VPFR-GI---DGLAVA-YGVAMNKLALPIPSTCP-----------------------------------------------------------EPFAK-LMEDCWNPDPHSRPS-----FTNILDQ---LT---------
IEP---DRPIGYGAFGVV---WSVTDP-------RDGK---RVALKKMPNV--F-QNLVS-----CK-RVFR-------ELKMLCFF--K----HDN-----VLSALDILQPPH------------------------IDYFEEIY--VVTEL-MQS---DLHKIIV----SPQ-----------------PL---SSDHVKVFLYQILRGLKYLHS--A---G---ILHRDIKPGNLLVN--S--------NCVL--------KICDFGLARVE-----ELDESRHM--------------TQ---EVVTQYYRAPEILM-----GSRHYSNAIDIWSVGCIFAELLG-RR-ILFQ-AQSPIQQLDLI-TDLLGTPSLEAMRTACEGAKAHILRGPHKQP--------------------------------SLPVLYTLSSQATHEAVH-LLCRMLVFDPSKRIS-----AKDALAHPYL-----------
--I-VLKRELGEGAFGKV---FLAECYN--LCPEQDKI---LVAVKTLK-D--A-SD-NA----RKD-FH-R-------EAELLTNL--Q----HEH-----IVKFYGVCVE-----------------------------GDPLI--MVFEY-MKHG--DLNKFLR-----AHGPDAV---LMAEGNPPTEL---TQSQMLHIAQQIAAGMVYLAS--Q---H---FVHRDLATRNCLVG--E--------NLLV--------KIGDFGMSRDV---Y--S--TDYY--------------RVGGHTMLPIRWMPPESIM------YRKFTTESDVWSLGVVLWEIFTYGK-QPWY-QLSNNEVIECI-TQGRVLQRPRTCP---------------------------------------------------------------QEVYE-LMLGCWQREPHMRKN-----IKGIHTL--L-----------
--I-VLKRELGEGAFGKV---FLAECYN--LSPTKDKM---LVAVKALK-D--P-TL-AA----RKD-FQ-R-------EAELLTNL--Q----HEH-----IVKFYGVCGD-----------------------------GDPLI--MVFEY-MKHG--DLNKFLR-----AHGPDAMILVDGQPRQAKGEL---GLSQMLHIASQIASGMVYLAS--Q---H---FVHRDLATRNCLVG--A--------NLLV--------KIGDFGMSRDV---Y--S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM------YRKFTTESDVWSFGVILWEIFTYGK-QPWF-QLSNTEVIECI-TQGRVLERPRVCP---------------------------------------------------------------KEVYD-VMLGCWQREPQQRLN-----IKEIYKIL-------------
---YELQETLGKGTYGKV---KRATER-------FSGR---VVAIKSIRKD--K-IKDEQ-----DM-VHIR------REIEIMSSL--N----HPH-----IISIYEVFEN-----------------------------KDKIV--IIMEY-ASKG--ELYDYIS----ERR-----------------RL---SERETRHFFRQIVSAVHYCHK--N---G---VVHRDLKLENILLD--D--------NCNI--------KIADFGLSNL-------YQKDKFL--------------QT---FCGSPLYASPEIVN-----GRPYRGPEVDSWALGVLLYTLVY-GT-MPFD-GF---DHKNLI-RQISSGEYREPTQP--------------------------------------------------------------SDARG-LIRWMLMVNPDRRAT-----IEDIANHWW-V----------
--F-KFGKILGEGSFSTV---VLAREL-------ATSR---EYAIKILEKR--H-IIKEN-----KVPYVTR-------ERDVMSRL--D----HPF-----FVKLYFTFQD-----------------------------DEKLY--FGLSY-AKNG--ELLKYIR----KIG-----------------SF---DETCTRFYTAEIVSALEYLHG--K---G---IIHRDLKPENILLN--E--------DMHI--------QITDFGTAKVLS----PESKQARA--------------NS---FVGTAQYVSPELLT------EKSACKSSDLWALGCIIYQLVA-GL-PPFR-AG---NEYLIF-QKIIKLEYDFPEKFF-------------------------------------------------------------PKARD-LVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
---YEPKEILGRGVSSVV---RRCIHK-------PTSQ---EYAVKVIDVT--G-GGSFS-----PE-EVRELREATLKEVDILRKV-SG----HPN-----IIQLKDTYET-----------------------------NTFFF--LVFDL-MKRG--ELFDYLT----EKV-----------------TL---SEKETRKIMRALLEVICTLHK--L---N---IVHRDLKPENILLD--D--------NMNI--------KLTDFGFSCQ-------LEPGERL--------------RE---VCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLA-GS-PPFW-HR---KQMLML-RMIMSGNYQFGSPEWDDYS---------------------------------------------------------DTVKD-LVSRFLVVQPQNRYT-----AEEALAHPFF-----------
---YQVGPLLGSGGFGSV---YSGIRV-------SDNL---PVAIKHVEKD--R-ISDWG-----EL-PNGTRV---PMEVVLLKKV--S----SGFS---GVIRLLDWFER-----------------------------PDSFV--LILER-PEPV-QDLFDFIT----ERG-----------------AL---QEELARSFFWQVLEAVRHCHN--C---G---VLHRDIKDENILID-LN--------RGEL--------KLIDFGSGA--------LLKDTVY--------------TD---FDGTRVYSPPEWIR-----YHRYHGRSAAVWSLGILLYDMVC-GD-IPFE-HD----------EEIIRGQVFFRQRVS-------------------------------------------------------------SECQH-LIRWCLALRPSDRPT-----FEEIQNHPWM-----------
---YRLGPLLGKGGFGTV---FAGHRL-------TDRL---QVAIKVIPRN--R-VLGWS-----PL-SDSVTC---PLEVALLWKV--GAGGGHPG-----VIRLLDWFET-----------------------------QEGFM--LVLERPLPAQ--DLFDYIT----EKG-----------------PL---GEGPSRCFFGQVVAAIQHCHS--R---G---VVHRDIKDENILID-LR--------RGCA--------KLIDFGSGA--------LLHDEPY--------------TD---FDGTRVYSPPEWIS-----RHQYHALPATVWSLGILLYDMVC-GD-IPFE-RD----------QEILEAELHFPAHVS-------------------------------------------------------------PDCCA-LIRRCLAPKPSSRPS-----LEEILLDPWM-----------
---YQVGAVLGSGGFGTV---YAGSRI-------ADGL---PVAVKHVVKE--R-VTEWG-----SL-GGATV----PLEVVLLRKV--GAAGGARG-----VIRLLDWFER-----------------------------PDGFL--LVLER-PEPA-QDLFDFIT----ERG-----------------AL---DEPLARRFFAQVLAAVRHCHS--C---G---VVHRDIKDENLLVD-LR--------SGEL--------KLIDFGSGA--------LLKDTVY--------------TD---FDGTRVYSPPEWIR-----YHRYHGRSATVWSLGVLLYDMVC-GD-IPFE-QD----------EEILRGRLLFRRRVS-------------------------------------------------------------PECQQ-LIRWCLSLRPSERPS-----LDQIAAHPWM-----------
---FELLKVLGQGSFGKVFLVRKVTRP-------DSGH---LYAMKVLKKA--T-LKVRD-----RV-RTKM-------ERDILADV--N----HPF-----VVKLHYAFQT-----------------------------EGKLY--LILDF-LRGG--DLFTRLS----KEV-----------------MF---TEEDVKFYLAELALGLDHLHS--L---G---IIYRDLKPENILLD--E--------EGHI--------KLTDFGLSKEA------IDHEKKA--------------YS---FCGTVEYMAPEVVN------RQGHSHSADWWSYGVLMFEMLT-GS-LPFQ-GK---DRKETM-TLILKAKLGMPQFLS-------------------------------------------------------------TEAQS-LLRALFKRNPANRLGSGPDGAEEIKRHV--FY---------
---FELLKVLGQGSYGKV---FLVRKV-------KGSDAGQLYAMKVLKKA--T-LKVRD-----RV-RSKM-------ERDILAEV--N----HPF-----IVKLHYAFQT-----------------------------EGKLY--LILDF-LRGG--DLFTRLS----KEV-----------------MF---TEEDVKFYLAELALALDHLHS--L---G---IIYRDLKPENILLD--E--------EGHI--------KITDFGLSKEA------IDHDKRA--------------YS---FCGTIEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GS-LPFQ-GK---DRKETM-ALILKAKLGMPQFLS-------------------------------------------------------------GEAQS-LLRALFKRNPCNRLGAGIDGVEEIKRHPFF-----------
---FELLKVLGQGSFGKV---FLVRKK-------TGPDAGQLYAMKVLKKA--S-LKVRD-----RV-RTKM-------ERDILVEV--N----HPF-----IVKLHYAFQT-----------------------------EGKLY--LILDF-LRGG--DVFTRLS----KEV-----------------LF---TEEDVKFYLAELALALDHLHQ--L---G---IVYRDLKPENILLD--E--------IGHI--------KLTDFGLSKES------VDQEKKA--------------YS---FCGTVEYMAPEVVN------RRGHSQSADWWSYGVLMFEMLT-GT-LPFQ-GK---DRNETM-NMILKAKLGMPQFLS-------------------------------------------------------------AEAQS-LLRMLFKRNPANRLGS--EGVEEIKRHLFF-----------
---YDIEGTLGKGNFAVV---KLGRHR-------ITKT---EVAIKIIDKS--Q-LDAVN-----LE-KIYR-------EVQIMKML--D----HPH-----IIKLYQVMET-----------------------------KSMLY--LVTEY-AKNG--EIFDYLA----NHG-----------------RL---NESEARRKFWQILSAVDYCHG--R---K---IVHRDLKAENLLLD--N--------NMNI--------KIADFGFGNF-------FKSGELL--------------AT---WCGSPPYAAPEVFE-----GQQYEGPQLDIWSMGVVLYVLVC-GA-LPFD-GP---TLPILR-QRVLEGRFRIPYFMS-------------------------------------------------------------EDCEH-LIRRMLVLDPSKRLT-----IAQIKEHKWM-----------
--L-RLEVKLGQGCFGEV---WMGTWN--------GTT---RVAIKTLK-P--G-TM-SP-----EA-FL-Q-------EAQVMKKL--R----HEK-----LVQLYAVVS------------------------------EEPIY--IVTEY-MSKG--SLLDFLK-----GE--------------TGKYL---RLPQLVDMAAQIASGMAYVER--M---N---YVHRDLRAANILVG--E--------NLVC--------KVADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELTTKGR-VPYP-GMVNREVLDQV-ERGYRMPCPPECP---------------------------------------------------------------ESLHD-LMCQCWRKEPEERPT-----FEYLQAF--L-----------
LCP---GRELGRGKFAVV---RKCIKK-------DSGK---EFAAKFMRKR--R-KGQDC-----RM-EIIH-------EIAVLELA-QD----NPW-----VINLHEVYET-----------------------------ASEMI--LVLEY-AAGG--EIFDQCVA--DREE-----------------AF---KEKDVQRLMRQILEGVHFLHT--R---D---VVHLDLKPQNILLT--S--------ESPLG-----DIKIVDFGLSRI-------LKNSEEL--------------RE---IMGTPEYVAPEILS------YDPISMATDMWSIGVLTYVMLT-GI-SPFL-GN---DKQETF-LNISQMNLSYSEEEFDVLS---------------------------------------------------------ESAVD-FIRTLLVKKPEDRAT-----AEECLKHPWL-----------
--L-RLLEKLGDGSFGVV---RRGEWD----APSGKTV---SVAVKCLK-PDVL-SQ-PEA---MDD-FI-R-------EVNAMHSL--D----HRN-----LIRLYGVVL------------------------------TPPMK--MVTEL-APLG--SLLDRLR-----KH---------------QGHF---LLGTLSRYAVQVAEGMGYLES--K---R---FIHRDLAARNLLLA--T--------RDLV--------KIGDFGLMRAL--PQ--N--DDHY--------------VMQEHRKVPFAWCAPESLK------TRTFSHASDTWMFGVTLWEMFTYGQ-EPWI-GLNGSQILHKIDKEGERLPRPEDCP---------------------------------------------------------------QDIYN-VMVQCWAHKPEDRPT-----FVALRDF--L-----------
--L-RLEVKLGQGCFGEV---WMGTWN--------GTT---KVAIKTLK-P--G-TM-MP-----EA-FL-Q-------EAQIMKKL--R----HDK-----LVPLYAVVS------------------------------EEPIY--IVTEF-MSKG--SLLDFLK-----EG--------------DGKYL---KLPQLVDMAAQIADGMAYIER--M---N---YIHRDLRAANILVG--E--------NLVC--------KIADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILQTELVTKGR-VPYP-GMVNREVLEQV-ERGYRMPCPQGCP---------------------------------------------------------------ESLHE-LMNLCWKKDPDERPT-----FEYIQSFL-------------
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