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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FRK 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
Other AURKC 43
TK BLK 241
TKL BRAF 456
TK CSF1R 582
TK DDR1 572
TK DDR2 563
TK EPHB4 615
TK EPHB6 670
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FLT4 845
TK FYN 271
TK HCK 241
TKL IRAK1 212
TKL IRAK3 165
TK JAK2 849
TK KDR 834
TK LCK 245
TKL LIMK1 339
TKL LIMK2 331
TK LTK 510
TK LYN 247
Other NEK5 4
TK PTK6 191
TK RET 724
TKL RIPK1 17
TK ROS1 1945
TK SRC 270
TK SRMS 230
TK SYK 371
TK TEK 824
TK TIE1 839
TK TNK1 116
TK TXK 271
TK TYK2 589
TK YES1 277
STE YSK4 1162
-----IQLLKRLGSGQFGEVWEGLWN-----------------NTTPVAV-KTL---K-P-GSM-DP---NDFL-R----EAQIMKNL-RHPKLIQLYAVCT--LEDPIYIITELMRHGSLQEYLQ-----ND-------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESR---NYIHRDLAARNVLVGE-----HNIY-KVADFGLARVFK-----------VD-----N--EDIY------------ESRHEIKLPVKWTAPEAIRSNK---FSIKSDVWSFGILLYEIITYGK-MP---------------YSGM---TGAQVIQML----AQ----NYR----LP---QPSNCP-------------------------------------------QQFYN-IMLECWNAEPKERPTFETLRWK--L--
-----ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAV-KTL---K-E-DTM-EV---EEFL-K----EAAVMKEI-KHPNLVQLLGVCT--REPPFYIITEFMTYGNLLDYLR-----EC-------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK---NFIHRDLAARNCLVGE-----NHLV-KVADFGLSRLM-------------------T--GDTY------------TAHAGAKFPIKWTAPESLAYNK---FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI---DLSQVYELL----EK----DYR----ME---RPEGCP-------------------------------------------EKVYE-LMRACWQWNPSDRPSFAEIHQA--F--
-----ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAV-KTL---K-E-DTM-EV---EEFL-K----EAAVMKEI-KHPNLVQLLGVCT--LEPPFYIVTEYMPYGNLLDYLR-----EC-------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKK---NFIHRDLAARNCLVGE-----NHVV-KVADFGLSRLM-------------------T--GDTY------------TAHAGAKFPIKWTAPESLAYNT---FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI---DLSQVYDLL----EK----GYR----ME---QPEGCP-------------------------------------------PKVYE-LMRACWKWSPADRPSFAETHQA--F--
----I-TLIRGLGHGAFGEVYEGQVSG-----------MPNDPSPLQVAV-KTL---P-E-VCS-EQD-ELDFL-M----EALIISKF-NHQNIVRCIGVSL--QSLPRFILLELMAGGDLKSFLR-----ETRP--------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN---HFIHRDIAARNCLLTCP--GPGRVA-KIGDFGMARDI-------------Y-----R--ASYY------------RKGGCAMLPVKWMPPEAFMEGI---FTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK---SNQEVLEFV----TS----GGR----MD---PPKNCP-------------------------------------------GPVYR-IMTQCWQHQPEDRPNFAIILER--I--
-----FEIGRPLGKGKFGNVYLARLK----------------ESHFIVAL-KVL---FKS-QIEKEG---LEHQLR---REIEIQAHL-QHPNILRLYNYFH--DARRVYLILEYAPRGELYKELQ----KSE----------------------------------------------------------------------KLDEQRTATIIEELADALTYCHDK---KVIHRDIKPENLLLGF-----RGEV-KIADFGWSV---------------------HTPSLRR------------KT---MCGTLDYLPPEMIEGRT---YDEKVDLWCIGVLCYELLV-GY-PP---------------FESA------SHSETY----RR----ILK----VD---VRFPLSMP-----------------------------------------LGARD-LISRLLRYQPLERLPLAQILKHPWV--
----L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAI-KTL---K-E-GTM-SP---EAFL-G----EANVMKAL-QHERLVRLYAVVT---KEPIYIVTEYMARGCLLDFLK-----TD-------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERM---NSIHRDLRAANILVSE-----ALCC-KIADFGLARII----------------------DSEY------------TAQEGAKFPIKWTAPEAIHFGV---FTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM---SNPEVIRNL----ER----GYR----MP---RPDTCP-------------------------------------------PELYRGVIAECWRSRPEERPTFEFLQSV--L--
-----ITVGQRIGSGSFGTVYKGKWH-------------------GDVAV-KML---N-VTAPT-PQQ-LQAFK-N----EVGVLRKT-RHVNILLFMGYST---KPQLAIVTQWCEGSSLYHHLH-----II--------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAK---SIIHRDLKSNNIFLHE-----DLTV-KIGDFGLATVK-------------S-----R--WSGS------------HQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQ-LP---------------YSNI-N-NRDQIIFMV----GR----GYLSPDLSK---VRSNCP-------------------------------------------KAMKR-LMAECLKKKRDERPLFPQILA---SI-
-----LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAV-KML---K-S-TAH-ADE-KEALM-S----ELKIMSHLGQHENIVNLLGACT--HGGPVLVITEYCCYGDLLNFLR-----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASK---NCIHRDVAARNVLLTN-----GHVA-KIGDFGLARDI-------------M-----N--DSNY------------IVKGNARLPVKWMAPESIFDCV---YTVQSDVWSYGILLWEIFSLGL-NP---------------YPGI-L-VNSKFYKLV----KD----GYQ----MA---QPAFAP-------------------------------------------KNIYS-IMQACWALEPTHRPTFQQICSFL----
-----LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAV-KIL---R-P-DAT-KNA-RNDFL-K----EVKIMSRL-KDPNIIRLLGVCV--QDDPLCMITDYMENGDLNQFLS-----AHQLEDKAAE--------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATL---NFVHRDLATRNCLVGE-----NFTI-KIADFGMSRNL-------------Y-----A--GDYY------------RVQGRAVLPIRWMAWECILMGK---FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL---TDEQVIENAGEFFRD----QGRQ-VYLS---RPPACP-------------------------------------------QGLYE-LMLRCWSRESEQRPPFSQLHRFL----
-----LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAV-KML---R-A-DAN-KNA-RNDFL-K----EIKIMSRL-KDPNIIHLLAVCI--TDDPLCMITEYMENGDLNQFLS-----RHEPPN-----------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSSL---NFVHRDLATRNCLVGK-----NYTI-KIADFGMSRNL-------------Y-----S--GDYY------------RIQGRAVLPIRWMSWESILLGK---FTTASDVWAFGVTLWETFTFCQEQP---------------YSQL---SDEQVIENT----GEFFRDQGRQ-TYLP---QPAICP-------------------------------------------DSVYK-LMLSCWRRDTKNRPSFQEIHL---LL-
----V-KIEEVIGAGEFGEVCRGRLK-------------APGKKESCVAI-KTL---K-G-GYT-ERQ-RREFL-S----EASIMGQF-EHPNIIRLEGVVT--NSMPVMILTEFMENGALDSFLR-----LN--------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEM---SYVHRDLAARNILVNS-----NLVC-KVSDFGLSRFLE----------ENS-----S--DPTY------------TSSLGGKIPIRWTAPEAIAFRK---FTSASDAWSYGIVMWEVMSFGE-RP---------------YWDM---SNQDVINAI----EQ----DYR----LP---PPPDCP-------------------------------------------TSLHQ-LMLDCWQKDRNARPRFPQVVSAL----
-----IKIEEVIGTGSFGEVRQGRLQ-------------PRGRREQTVAI-QAL---W-A-GGA-ESL-QMTFL-G----RAAVLGQF-QHPNILRLEGVVT--KSRPLMVLTEFMELGPLDSFLR-----QR--------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSF---AFVHRSLSAHSVLVNS-----HLVC-KVARLGHSPQG-------------------------------------------PSCLLRWAAPEVIAHGK---HTTSSDVWSFGILMWEVMSYGE-RP---------------YWDM---SEQEVLNAI----EQ----EFR----LP---PPPGCP-------------------------------------------PGLHL-LMLDTWQKDRARRPHFDQLVA---AF-
---VI--LGELLGKGNFGEVYKGTLK-----------------DKTSVAV-KTC---K-E-DLP-QEL-KIKFL-Q----EAKILKQY-DHPNIVKLIGVCT--QRQPVYIIMELVSGGDFLTFLR-----RK--------------------------------------------------------------------KDELKLKQLVKFSLDAAAGMLYLESK---NCIHRDLAARNCLVGE-----NNVL-KISDFGMSRQE-------------------D--GGVY------------SSSGLKQIPIKWTAPEALNYGR---YSSESDVWSFGILLWETFSLGV-CP---------------YPGM---TNQQAREQV----ER----GYR----MS---APQHCP-------------------------------------------EDISK-IMMKCWDYKPENRPKFSELQKEL----
----L-VLGEQIGRGNFGEVFSGRLR----------------ADNTLVAV-KSC---R-E-TLP-PDL-KAKFL-Q----EARILKQY-SHPNIVRLIGVCT--QKQPIYIVMELVQGGDFLTFLR-----TE--------------------------------------------------------------------GARLRVKTLLQMVGDAAAGMEYLESK---CCIHRDLAARNCLVTE-----KNVL-KISDFGMSREE-------------A-----D--GVYA------------ASGGLRQVPVKWTAPEALNYGR---YSSESDVWSFGILLWETFSLGA-SP---------------YPNL---SNQQTREFV----EK----GGR----LP---CPELCP-------------------------------------------DAVFR-LMEQCWAYEPGQRPSFSTIYQEL----
----L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAV-KML---K-S-DAT-EKD-LSDLI-S----EMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLQ-----ARRPPGLEY-----------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK---KCIHRDLAARNVLVTE-----DNVM-KIADFGLARDI-------------H-----H--IDYY------------KKTTNGRLPVKWMAPEALFDRI---YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV---PVEELFKLL----KE----GHR----MD---KPSNCT-------------------------------------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL----
-----LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAV-KML---K-D-DAT-EKD-LSDLV-S----EMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLR-----ARRPPGMEY-----------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ---KCIHRDLAARNVLVTE-----NNVM-KIADFGLARDI-------------N-----N--IDYY------------KKTTNGRLPVKWMAPEALFDRV---YTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI---PVEELFKLL----KE----GHR----MD---KPANCT-------------------------------------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL----
-----LTLGKPLGEGCFGQVVMAEAIGI---------DKDRAAKPVTVAV-KML---K-D-DAT-DKD-LSDLV-S----EMEMMKMIGKHKNIINLLGACT--QGGPLYVLVEYAAKGNLREFLR-----ARRPPGLDY-----------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQ---KCIHRDLAARNVLVTE-----DNVM-KIADFGLARDV-------------H-----N--LDYY------------KKTTNGRLPVKWMAPEALFDRV---YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI---PVEELFKLL----KE----GHR----MD---KPANCT-------------------------------------------HDLYM-IMRECWHAAPSQRPTFKQLVEDL----
----L-VLGKPLGEGCFGQVVRAEAFGM---------DPARPDQASTVAV-KML---K-D-NAS-DKD-LADLV-S----EMEVMKLIGRHKNIINLLGVCT--QEGPLYVIVECAAKGNLREFLR-----ARRPPGPDL-----------------------------------------------------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESR---KCIHRDLAARNVLVTE-----DNVM-KIADFGLARGV-------------H-----H--IDYY------------KKTSNGRLPVKWMAPEALFDRV---YTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI---PVEELFSLL----RE----GHR----MD---RPPHCP-------------------------------------------PELYG-LMRECWHAAPSQRPTFKQLVEAL----
-----ITLERRLGTGCFGDVWLGTWN-----------------GSTKVAV-KTL---K-P-GTM-SP---KAFL-E----EAQVMKLL-RHDKLVQLYAVVS---EEPIYIVTEFMCHGSLLDFLK-----NP-------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERM---NYIHRDLRAANILVGE-----RLAC-KIADFGLARLI-------------------K--DDEY------------NPCQGSKFPIKWTAPEAALFGR---FTIKSDVWSFGILLTELITKGR-IP---------------YPGM---NKREVLEQV----EQ----GYH----MP---CPPGCP-------------------------------------------ASLYE-AMEQTWRLDPEERPTFEYLQSFL----
-----LHLGRVLGYGAFGKVVEASAFG-----------IHKGSSCDTVAV-KML---K-E-GAT-ASE-HRALM-S----ELKILIHIGNHLNVVNLLGACT-KPQGPLMVIVEFCKYGNLSNFLR-----AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASR---KCIHRDLAARNILLSE-----SDVV-KICDFGLARDI-------------Y-----K--DPDY------------VRKGSARLPLKWMAPESIFDKV---YTTQSDVWSFGVLLWEIFSLGA-SP---------------YPGV-Q-INEEFCQRL----RD----GTR----MR---APELAT-------------------------------------------PAIRR-IMLNCWSGDPKARPAFSELVEIL----
-----LQLIKRLGNGQFGEVWMGTWN-----------------GNTKVAI-KTL---K-P-GTM-SP---ESFL-E----EAQIMKKL-KHDKLVQLYAVVS---EEPIYIVTEYMNKGSLLDFLK-----DG-------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERM---NYIHRDLRSANILVGN-----GLIC-KIADFGLARLI-------------------E--DNEY------------TARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILLTELVTKGR-VP---------------YPGM---NNREVLEQV----ER----GYR----MP---CPQDCP-------------------------------------------ISLHE-LMIHCWKKDPEERPTFEYLQSFL----
-----LKLEKKLGAGQFGEVWMATYN-----------------KHTKVAV-KTM---K-P-GSM-SV---EAFL-A----EANVMKTL-QHDKLVKLHAVVT---KEPIYIITEFMAKGSLLDFLK-----SD-------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR---NYIHRDLRAANILVSA-----SLVC-KIADFGLARVI-------------------E--DNEY------------TAREGAKFPIKWTAPEAINFGS---FTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM---SNPEVIRAL----ER----GYR----MP---RPENCP-------------------------------------------EELYN-IMMRCWKNRPEERPTFEYIQSV--L--
-FSEE----LKIGEGGFGCVYRAVMR----------------NTV--YAV-KRL---KEN-ADLEWT---AVKQSFL--TEVEQLSRF-RHPNIVDFAGYCA--QNGFYCLVYGFLPNGSLEDRLHCQTQACP----------------------------------------------------------------------PLSWPQRLDILLGTARAIQFLHQDS-PSLIHGDIKSSNVLLDE-----RLTP-KLGDFGLARFSRFAG----------SSPSQSSMVART------------QT---VRGTLAYLPEEYIKTGR---LAVDTDTFSFGVVVLETLA-GQ-RA---------------VKTHG-AR-TKYLKDL----VE----EEA----EE---AGVALRST---QSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQ-LACCCLHRRAKRRPPMTQVYE----RL
FHKDF-----LIGEGEIFEVYRVEIQ----------------NLT--YAV-KLF---KQE-KKMQCK---KHWKRFL--SELEVLLLF-HHPNILELAAYFT--ETEKFCLIYPYMRNGTLFDRLQC-VGDTA----------------------------------------------------------------------PLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDD-----QFQP-KLTDFAMAHFRSHL-------------EHQSCTINMT------------SS---SSKHLWYMPEEYIRQGK---LSIKTDVYSFGIVIMEVLT-GC-RV---------------VLDD---PKHIQLRDL----LR----ELM----EK---RGLDSCLSFLDKKVPPC---------------------------PRNFSAKLFC-LAGRCAATRAKLRPSMDEVLNT---L-
-----LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAV-KKL---Q-H-STE--EH-LRDFE-R----EIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ-----KH--------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK---RYIHRDLATRNILVEN-----ENRV-KIGDFGLTKVL------------PQ-----D--KEYY------------KVKEPGESPIFWYAPESLTESK---FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM---IVFHLIELL----KN----NGR----LP---RPDGCP-------------------------------------------DEIYM-IMTECWNNNVNQRPSFRDLA----LRV
-----LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAV-KML---K-E-GAT-HSE-HRALM-S----ELKILIHIGHHLNVVNLLGACT-KPGGPLMVIVEFCKFGNLSTYLR-----SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASR---KCIHRDLAARNILLSE-----KNVV-KICDFGLARDI-------------Y-----K--DPDY------------VRKGDARLPLKWMAPETIFDRV---YTIQSDVWSFGVLLWEIFSLGA-SP---------------YPGV-K-IDEEFCRRL----KE----GTR----MR---APDYTT-------------------------------------------PEMYQ-TMLDCWHGEPSQRPTFSELVEHL----
-----LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAV-KSL---K-Q-GSM-SP---DAFL-A----EANLMKQL-QHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLK-----TP-------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER---NYIHRDLRAANILVSD-----TLSC-KIADFGLARLI-------------------E--DNEY------------TAREGAKFPIKWTAPEAINYGT---FTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM---TNPEVIQNL----ER----GYR----MV---RPDNCP-------------------------------------------EELYQ-LMRLCWKERPEDRPTFDYLRSV--L--
---LI--HGEVLGKGCFGQAIKVTHR----------------ETGEVMVM-KEL---I---RFD-EET-QRTFL-K----EVKVMRCL-EHPNVLKFIGVLY--KDKRLNFITEYIKGGTLRGIIK-----SM--------------------------------------------------------------------DSQYPWSQRVSFAKDIASGMAYLHSM---NIIHRDLNSHNCLVRE-----NKNV-VVADFGLARLM-------------V-----D--EKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRS---YDEKVDVFSFGIVLCEIIGRVN-AD---------------PDYL-P-RTMDFGLNV----RG----FLD----RY---CPPNCP-------------------------------------------PSFFP-ITVRCCDLDPEKRPSFVKLEH---WL-
---LI--HGEVLGKGFFGQAIKVTHK-----------------ATGKVMVMKEL-----I-RCD-EET-QKTFL-T----EVKVMRSL-DHPNVLKFIGVLY--KDKKLNLLTEYIEGGTLKDFLR-----SM---------------------------------------------------------------------DPFPWQQKVRFAKGIASGMAYLHSM---CIIHRDLNSHNCLIKL-----DKTV-VVADFGLSRLIVEERKRAPMEKATT-----------KKRTL---RKNDRKKRYTVVGNPYWMAPEMLNGKS---YDETVDIFSFGIVLCEIIGQVY-AD---------------PDCL-P-RTLDFGLNV----KL----FWE----KF---VPTDCP-------------------------------------------PAFFP-LAAICCRLEPESRPAFSKLED---SF-
----V-TLLRALGHGAFGEVYEGLVIG-----------LPGDSSPLQVAI-KTL---P-E-LCS-PQD-ELDFL-M----EALIISKF-RHQNIVRCVGLSL--RATPRLILLELMSGGDMKSFLR-----HSRP--------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEEN---HFIHRDIAARNCLLSCA--GPSRVA-KIGDFGMARDI-------------Y-----R--ASYY------------RRGDRALLPVKWMPPEAFLEGI---FTSKTDSWSFGVLLWEIFSLGY-MP---------------YPGR---TNQEVLDFV----VG----GGR----MD---PPRGCP-------------------------------------------GPVYR-IMTQCWQHEPELRPSFASILERL----
-----IKLVKRLGAGQFGEVWMGYYN-----------------NSTKVAV-KTL---K-P-GTM-SV---QAFL-E----EANLMKTL-QHDKLVRLYAVVT--REEPIYIITEYMAKGSLLDFLK-----SD-------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERK---NYIHRDLRAANVLVSE-----SLMC-KIADFGLARVI-------------------E--DNEY------------TAREGAKFPIKWTAPEAINFGC---FTIKSDVWSFGILLYEIVTYGK-IP---------------YPGR---TNADVMTAL----SQ----GYR----MP---RVENCP-------------------------------------------DELYD-IMKMCWKEKAEERPTFDYLQSV--L--
-----YDVIKAIGQGAFGKAYLAKGK----------------SDSKHCVI-KEI---NFE-KMPIQE---KEASKK----EVILLEKM-KHPNIVAFFNSFQ--ENGRLFIVMEYCDGGDLMKRINR--QRGV----------------------------------------------------------------------LFSEDQILGWFVQISLGLKHIHDR---KILHRDIKAQNIFLSK-----NGMVAKLGDFGIARVL-------------------NNSMELA------------RT---CIGTPYYLSPEICQNKP---YNNKTDIWSLGCVLYELCT-LK-HP---------------FEGN------NLQQLV----LK----ICQ----AH---FAPISPGF---S-------------------------------------RELHS-LISQLFQVSPRDRPSINSILKRPFL--
----F-TLCRKLGSGYFGEVFEGLWK-----------------DRVQVAI-KVI---S-R-DNL-LH--QQMLQ-S----EIQAMKKL-RHKHILALYAVVS--VGDPVYIITELMAKGSLLELLR-----DS-------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQ---NYIHRDLAARNILVGE-----NTLC-KVGDFGLARLI----------------------KEDV------------YLSHDHNIPYKWTAPEALSRGH---YSTKSDVWSFGILLHEMFSRGQ-VP---------------YPGM---SNHEAFLRV----DA----GYR----MP---CPLECP-------------------------------------------PSVHK-LMLTCWCRDPEQRPCFKALRERL----
----L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYTTVAV-KML---K-E-NAS-PSE-LRDLL-S----EFNVLKQV-NHPHVIKLYGACS--QDGPLLLIVEYAKYGSLRGFLR-----ESRKVGPGYLGSG---------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM---KLVHRDLAARNILVAE-----GRKM-KISDFGLSRDV-------------Y-----E--EDSY------------VKRSQGRIPVKWMAIESLFDHI---YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI---PPERLFNLL----KT----GHR----ME---RPDNCS-------------------------------------------EEMYR-LMLQCWKQEPDKRPVFADISKDL----
--LES----AELDSGGFGKVSLCFHR-----------------TQGLMIM-KTV--YK-G-PNC-IEH-NEALL-E----EAKMMNRL-RHSRVVKLLGVII--EEGKYSLVMEYMEKGNLMHVLK-----AE---------------------------------------------------------------------MSTPLSVKGRIILEIIEGMCYLHGK---GVIHKDLKPENILVDN-----DFHI-KIADLGLASFKMWS------KLNNE---------EHNELR------EVDGTAKKNGGTLYYMAPEHLNDVNA-KPTEKSDVYSFAVVLWAIFA-NK-EP---------------YENA-I-CEQQLIMCI----KS----GNR----PDVDDITEYCP-------------------------------------------REIIS-LMKLCWEANPEARPTFPGIEEK--F--
---LT--LRLLLGSGAFGEVYEGTAVDI----------LGVGSGEIKVAV-KTL---K-K-GST-DQE-KIEFL-K----EAHLMSKF-NHPNILKQLGVCL--LNEPQYIILELMEGGDLLTYLR-----KARM--------------------------------------------------------------ATFYGPLLTLVDLVDLCVDISKGCVYLERM---HFIHRDLAARNCLVSVKDYTSPRIV-KIGDFGLARDI-------------Y-----K--NDYY------------RKRGEGLLPVRWMAPESLMDGI---FTTQSDVWSFGILIWEILTLGH-QP---------------YPAH---SNLDVLNYV----QT----GGR----LE---PPRNCP-------------------------------------------DDLWN-LMTQCWAQEPDQRPTFHRIQDQL----
----L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAI-KTL---K-P-GTM-SP---EAFL-Q----EAQVMKKL-RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLK-----GE-------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGE-----NLVC-KVADFGLARLI-------------------E--DNEY------------TARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM---VNREVLDQV----ER----GYR----MP---CPPECP-------------------------------------------ESLHD-LMCQCWRKEPEERPTFEYLQAF--L--
---FA--LGRKLGEGYFGEVWEGLWL-----------------GSLPVAI-KVI---K-S-ANM-K---LTDLA-K----EIQTLKGL-RHERLIRLHAVCS--GGEPVYIVTELMRKGNLQAFLG-----TP-------------------------------------------------------------------EGRALRLPPLLGFACQVAEGMSYLEEQ---RVVHRDLAARNVLVDD-----GLAC-KVADFGLARLL-------------------K--DDIY------------SPSSSSKIPVKWTAPEAANYRV---FSQKSDVWSFGVLLHEVFTYGQ-CP---------------YEGM---TNHETLQQI----MR----GYR----LP---RPAACP-------------------------------------------AEVYV-LMLECWRSSPEERPSFATLREKL----
--TLE---DKELGSGNFGTVKKGYYQ--------------MKKVVKTVAV-KIL---K-N-EAN-DPALKDELL-A----EANVMQQL-DNPYIVRMIGICE---AESWMLVMEMAELGPLNKYLQ-----QN---------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEES---NFVHRDLAARNVLLVT-----QHYA-KISDFGLSKAL-------------R-----A--DENY-----------YKAQTHGKWPVKWYAPECINYYK---FSSKSDVWSFGVLMWEAFSYGQ-KP---------------YRGM---KGSEVTAML----EK----GER----MG---CPAGCP-------------------------------------------REMYD-LMNLCWTYDVENRPGFAAVE----LRL
-----IKFQDVIGEGNFGQVLKARIK--------------KDGLRMDAAI-KRM---K-E-YAS-KDD-HRDFA-G----ELEVLCKLGHHPNIINLLGACE--HRGYLYLAIEYAPHGNLLDFLR-----KSRVLETDP-----------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQK---QFIHRDLAARNILVGE-----NYVA-KIADFGLSRGQ-----------------------EVY------------VKKTMGRLPVRWMAIESLNYSV---YTTNSDVWSYGVLLWEIVSLGG-TP---------------YCGM---TCAELYEKL----PQ----GYR----LE---KPLNCD-------------------------------------------DEVYD-LMRQCWREKPYERPSFAQILV---SL-
-----ITFEDLIGEGNFGQVIRAMIK--------------KDGLKMNAAI-KML---K-E-YAS-END-HRDFA-G----ELEVLCKLGHHPNIINLLGACK--NRGYLYIAIEYAPYGNLLDFLR-----KSRVLETDP-----------------------------------------------------AFAREHGTASTLSSRQLLRFASDAANGMQYLSEK---QFIHRDLAARNVLVGE-----NLAS-KIADFGLSRGE-----------------------EVY------------VKKTMGRLPVRWMAIESLNYSV---YTTKSDVWSFGVLLWEIVSLGG-TP---------------YCGM---TCAELYEKL----PQ----GYR----ME---QPRNCD-------------------------------------------DEVYE-LMRQCWRDRPYERPPFAQIALQ--L--
--VCR---GELLGSGCFGVVHRGLWT-------------LPSGKSVPVAV-KSLRVGP-E-GPM-GTE-LGDFL-R----EVSVMMNL-EHPHVLRLHGLVL---GQPLQMVMELAPLGSLHARLT-----AP------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGAR---GLVHRDLATRNLLLAS-----PRTI-KVADFGLVRPL------------GG-----A--RGRY------------VMGGPRPIPYAWCAPESLRHGA---FSSASDVWMFGVTLWEMFSGGE-EP---------------WAGV---PPYLILQRL----ED----RAR----LP---RPPLCS-------------------------------------------RALYS-LALRCWAPHPADRPSFSHLE----GLL
----L-AFIKEIGSGQFGVVHLGEWR-----------------SHIQVAI-KAI---N-E-GSM-SE---EDFI-E----EAKVMMKL-SHSKLVQLYGVCI--QRKPLYIVTEFMENGCLLNYLR-----EN--------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLERN---GYIHRDLAARNCLVSS-----TCIV-KISDFGMTRYV-------------------L--DDEY------------VSSFGAKFPIKWSPPEVFLFNK---YSSKSDVWSFGVLMWEVFTEGK-MP---------------FENK---SNLQVVEAI----SE----GFR----LY---RPHLAP-------------------------------------------MSIYE-VMYSCWHEKPEGRPTFAELLR---AV-
----L-KKIRDLGEGHFGKVSLYCYDP------------TNDGTGEMVAV-KAL---K-A-DCG-PQH-RSGWK-Q----EIDILRTL-YHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLP-----RH----------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHAQ---HYIHRDLAARNVLLDN-----DRLV-KIGDFGLAKAV------------PE-----G--HEYY------------RVREDGDSPVFWYAPECLKEYK---FYYASDVWSFGVTLYELLTHCD-SSQSPPTKF-LELIGIAQGQM---TVLRLTELL----ER----GER----LP---RPDKCP-------------------------------------------CEVYH-LMKNCWETEASFRPTFENLIP---IL-
----L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAI-KTL---K-P-GTM-MP---EAFL-Q----EAQIMKKL-RHDKLVPLYAVVS---EEPIYIVTEFMSKGSLLDFLK-----EG-------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERM---NYIHRDLRAANILVGE-----NLVC-KIADFGLARLI-------------------E--DNEY------------TARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM---VNREVLEQV----ER----GYR----MP---CPQGCP-------------------------------------------ESLHE-LMNLCWKKDPDERPTFEYIQSFL----
-----WTKGEILGKGAYGTVYCGLTS----------------QGQ-LIAV-KQV---ALD-TSNKLA---AEKEYRKLQEEVDLLKAL-KHVNIVAYLGTCL--QENTVSIFMEFVPGGSISSIIN----RFG----------------------------------------------------------------------PLPEMVFCKYTKQILQGVAYLHEN---CVVHRDIKGNNVMLMP-----TGII-KLIDFGCARRLAWA-------------GLNGTHSDML------------KS---MHGTPYWMAPEVINESG---YGRKSDIWSIGCTVFEMAT-GK-PP---------------LASM-----DRMAAMF----YI----GAH----RG---LMPPLPDHFS---------------------------------------ENAAD-FVRMCLTRDQHERPSALQLLKHSFL--
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