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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FRK 203
TK ABL1 261
TK ABL2 288
TKL ACVR1 208
TKL ACVR1B 207
TK ALK 1116
Other AURKA 133
TK BLK 241
TK BMX 422
TK BTK 402
CMGC CDC2L5 705
CMGC CDK9 2.7.11.23
CMGC CDKL3 4
TK CSK 195
TK DDR1 572
TK DDR2 563
TK EGFR 712
TK EPHB1 619
TK EPHB2 621
TK EPHB4 615
TK EPHB6 670
TK ERBB4 718
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK INSRR 979
TKL IRAK4 186
TK ITK 363
TK JAK2 849
TK LTK 510
TK LYN 247
STE MAP3K15 649
STE MAP3K2 356
STE MAP3K3 362
STE MAP3K5 677
STE MAP3K6 645
TK MATK 235
TK MUSK 575
Other NEK1 4
Other NEK2 8
Other NEK4 6
Other NEK5 4
Other NEK8 4
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
AGC PDPK1 82
AGC PKN1 615
AGC PRKACA 44
AGC PRKACG 44
AGC PRKCA 339
AGC PRKCE 408
AGC PRKX 49
TK PTK2 422
TK ROS1 1945
TK SRC 270
STE STK3 27
STE STK4 30
TK SYK 371
STE TAOK2 28
TK TEC 370
TKL TGFBR1 205
TK TNK1 116
TK TNK2 150
TK TXK 271
TK YES1 277
STE YSK4 1162
---IQLLKRLGSGQFGEVWEGLWN-----------------NTTPVAVKTL---K-P--G-SM-DP---N-D-FL-R----EAQIMKNL--R---HPKLIQLYAVCT--L----------EDPIYIITELMRHGSLQEYLQ-----ND----------------------TGSKI--HLTQQVDMAAQVASGMAYLESR--------NYIHRDLAARNVLVG-E-----HNIY-KVADFGLARVFK---VD---N--EDIY--------------ESRHEIKLPVKWTAPEAIR------SNKFSIKSDVWSFGILLYEIITYGK----------MP---------------YSGM-----TGAQVIQML----AQ----NYR---LPQPSNCP-------------------------------QQFYN-IMLECWNAEPKERPT-------FETLRWK--L--------------
---ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTL---K-E--D-TM-EV---E-E-FL-K----EAAVMKEI--K---HPNLVQLLGVCT--R----------EPPFYIITEFMTYGNLLDYLR-----EC----------------------NRQEV--NAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVG-E-----NHLV-KVADFGLSRLM---------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNKFSIKSDVWAFGVLLWEIATYGM----------SP---------------YPGI-----DLSQVYELL----EK----DYR---MERPEGCP-------------------------------EKVYE-LMRACWQWNPSDRPS-------FAEIHQA--F--------------
---ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTL---K-E--D-TM-EV---E-E-FL-K----EAAVMKEI--K---HPNLVQLLGVCT--L----------EPPFYIVTEYMPYGNLLDYLR-----EC----------------------NREEV--TAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVG-E-----NHVV-KVADFGLSRLM---------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNTFSIKSDVWAFGVLLWEIATYGM----------SP---------------YPGI-----DLSQVYDLL----EK----GYR---MEQPEGCP-------------------------------PKVYE-LMRACWKWSPADRPS-------FAETHQA--F--------------
--I-TLLECVGKGRYGEVWRGSWQ----------------GEN--VAVKIF---SSR--D-EKSWF---R-E-T-------ELYNTVML--R---HENILGFIASDM--TSR------HSSTQLWLITHYHEMGSLYDYLQ-----LT-------------------------TL--DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVK-K-----NGQC-CIADLGLAVMHSQ-----STNQLDVGN--------------NP---RVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVAR-RMVSNGIVEDYKPP---------------FYDVVPNDPSFEDMRKVV----CV----DQQ---RPNIPNRWFSDPTL-------------------------TSLAK-LMKECWYQNPSARLT-------ALRIKK----TL------------
-IV--LQEIIGKGRFGEVWRGRWR----------------GGD--VAVKIF---SSR--E-ERSWF---R-E-A-------EIYQTVML--R---HENILGFIAADN--KDN------GTWTQLWLVSDYHEHGSLFDYLN-----RY-------------------------TV--TIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVK-K-----NGMC-AIADLGLAVRHDA-----VTDTIDIAP--------------NQ---RVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIAR-RCNSGGVHEEYQLP---------------YYDLVPSDPSIEEMRKVV----CD----QKL---RPNIPNWWQSYEAL-------------------------RVMGK-MMRECWYANGAARLT-------ALRIKK----TL------------
--I-TLIRGLGHGAFGEVYEGQVSG-----------MPNDPSPLQVAVKTL---P-E--V-CS-EQD-EL-D-FL-M----EALIISKF--N---HQNIVRCIGVSL--Q----------SLPRFILLELMAGGDLKSFLR-----ETRP-----------------RPSQPSSL--AMLDLLHVARDIACGCQYLEEN--------HFIHRDIAARNCLLT-CP--GPGRVA-KIGDFGMARDI-----Y---R--ASYY--------------RKGGCAMLPVKWMPPEAFM------EGIFTSKTDTWSFGVLLWEIFSLGY----------MP---------------YPSK-----SNQEVLEFV----TS----GGR---MDPPKNCP-------------------------------GPVYR-IMTQCWQHQPEDRPN-------FAIILER--I--------------
---FEIGRPLGKGKFGNVYLAREK----------------QSKFILALKVL---FKA--QLEKAGV---E-H-QLRR----EVEIQSHL--R---HPNILRLYGYFH--D----------ATRVYLILEYAPLGTVYRELQ----KLS-------------------------KF--DEQRTATYITELANALSYCHSK--------RVIHRDIKPENLLLG-S-----AGEL-KIADFGWSV-----------HAPSSRR--------------TT---LCGTLDYLPPEMIE------GRMHDEKVDLWSLGVLCYEFLV-GK----------PP---------------FEAN--------TYQETY----KR----ISR---VEFTFPDFVT-----------------------------EGARD-LISRLLKHNPSQRPM-------LREVLEHPWI--------------
--L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAIKTL---K-E--G-TM-SP---E-A-FL-G----EANVMKAL--Q---HERLVRLYAVVT-------------KEPIYIVTEYMARGCLLDFLK-----TD----------------------EGSRL--SLPRLIDMSAQIAEGMAYIERM--------NSIHRDLRAANILVS-E-----ALCC-KIADFGLARII------------DSEY--------------TAQEGAKFPIKWTAPEAIH------FGVFTIKADVWSFGVLLMEVVTYGR----------VP---------------YPGM-----SNPEVIRNL----ER----GYR---MPRPDTCP-------------------------------PELYRGVIAECWRSRPEERPT-------FEFLQSV--L--------------
---ITLLKELGSGQFGVVQLGKWK-----------------GQYDVAVKMI---K-E--G-SM-SE---D-E-FF-Q----EAQTMMKL--S---HPKLVKFYGVCS--K----------EYPIYIVTEYISNGCLLNYLR-----SH-----------------------GKGL--EPSQLLEMCYDVCEGMAFLESH--------QFIHRDLAARNCLVD-R-----DLCV-KVSDFGMTRYV---------L--DDQY--------------VSSVGTKFPVKWSAPEVFH------YFKYSSKSDVWAFGILMWEVFSLGK----------QP---------------YDLY-----DNSQVVLKV----SQ----GHR---LYRPHLAS-------------------------------DTIYQ-IMYSCWHELPEKRPT-------FQQLLSS--I--------------
---LTFLKELGTGQFGVVKYGKWR-----------------GQYDVAIKMI---K-E--G-SM-SE---D-E-FI-E----EAKVMMNL--S---HEKLVQLYGVCT--K----------QRPIFIITEYMANGCLLNYLR-----EM-----------------------RHRF--QTQQLLEMCKDVCEAMEYLESK--------QFLHRDLAARNCLVN-D-----QGVV-KVSDFGLSRYV---------L--DDEY--------------TSSVGSKFPVRWSPPEVLM------YSKFSSKSDIWAFGVLMWEIYSLGK----------MP---------------YERF-----TNSETAEHI----AQ----GLR---LYRPHLAS-------------------------------EKVYT-IMYSCWHEKADERPT-------FKILLSN--I--------------
--F-DIIGIIGEGTYGQVYKARDK----------------DTGEMVALKKV---RLD--N-EKEGF---P-I-TAIR----EIKILRQL--T---HQSIINMKEIVT--DKEDALDFKKDKGAFYLVFEYMDH-DLMGLLE---SGLV-------------------------HF--NENHIKSFMRQLMEGLDYCHKK--------NFLHRDIKCSNILLN-N-----RGQI-KLADFGLARLY--------SSEESRPY--------------TN---KVITLWYRPPELLL-----GEERYTPAIDVWSCGCILGELFT-KK----------PI---------------FQAN-----QELAQLELI----SR----ICG---SPCPAVWPDVIKLPYFNTMKPKKQY--RRKLREEFVFIPAAALD-LFDYMLALDPSKRCT-------AEQALQCEF-L-------------
---YEKLAKIGQGTFGEVFKARHR----------------KTGQKVALKKV---LME--N-EKEGF---P-I-TALR----EIKILQLL--K---HENVVNLIEICR--TKASP--YNRCKGSIYLVFDFCEH-DLAGLLS---NVLV-------------------------KF--TLSEIKRVMQMLLNGLYYIHRN--------KILHRDMKAANVLIT-R-----DGVL-KLADFGLARAFSL-----AKNSQPNRY--------------TN---RVVTLWYRPPELLL-----GERDYGPPIDLWGAGCIMAEMWT-RS----------PI---------------MQGN-----TEQHQLALI----SQ----LCG---SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALD-LIDKLLVLDPAQRID-------SDDALNHDFF--------------
---YETLGKVGEGSYGTVMKCKHK----------------NTGQIVAIKIF---YER--P-EQSVN---K---IAMR----EIKFLKQF--H---HENLVNLIEVFR--Q----------KKKIHLVFEFIDHTVLDELQH----YCH-------------------------GL--ESKRLRKYLFQILRAIDYLHSN--------NIIHRDIKPENILVS-Q-----SGIT-KLCDFGFARTL---------AAPGDIY--------------TD---YVATRWYRAPELVL-----KDTSYGKPVDIWALGCMIIEMAT-GN----------PY---------------LPSS-----SDLDLLHKI----VL----KVG---N-LSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLAD-IVHACLQIDPADRIS-------SSDLLHHEYF--------------
---LKLLQTIGKGEFGDVMLGDYR------------------GNKVAVKCI---K-N--D-AT-AQ-----A-FL-A----EASVMTQL--R---HSNLVQLLGVIV-EE----------KGGLYIVTEYMAKGSLVDYLR-----SR----------------------GRSVL--GGDCLLKFSLDVCEAMEYLEGN--------NFVHRDLAARNVLVS-E-----DNVA-KVSDFGLTKEA---------------S--------------STQDTGKLPVKWTAPEALR------EKKFSTKSDVWSFGILLWEIYSFGR----------VP---------------YPRI-----PLKDVVPRV----EK----GYK---MDAPDGCP-------------------------------PAVYE-VMKNCWHLDAAMRPS-------FLQLREQL----------------
---LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL---R-P--D-AT-KNA-RN-D-FL-K----EVKIMSRL--K---DPNIIRLLGVCV--Q----------DDPLCMITDYMENGDLNQFLS-----AHQLEDKAAE-----GAPGDGQAAQGPTI--SYPMLLHVAAQIASGMRYLATL--------NFVHRDLATRNCLVG-E-----NFTI-KIADFGMSRNL-----Y---A--GDYY--------------RVQGRAVLPIRWMAWECIL------MGKFTTASDVWAFGVTLWEVLMLCRA---------QP---------------FGQL-----TDEQVIENAGEFFRD----QGRQVYLSRPPACP-------------------------------QGLYE-LMLRCWSRESEQRPP-------FSQLHRFL----------------
---LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKML---R-A--D-AN-KNA-RN-D-FL-K----EIKIMSRL--K---DPNIIHLLAVCI--T----------DDPLCMITEYMENGDLNQFLS-----RHEPPN--------------SSSSDVRTV--SYTNLKFMATQIASGMKYLSSL--------NFVHRDLATRNCLVG-K-----NYTI-KIADFGMSRNL-----Y---S--GDYY--------------RIQGRAVLPIRWMSWESIL------LGKFTTASDVWAFGVTLWETFTFCQE---------QP---------------YSQL-----SDEQVIENT----GEFFRDQGRQTYLPQPAICP-------------------------------DSVYK-LMLSCWRRDTKNRPS-------FQEIHL---LL-------------
--F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKIPVAIKEL---R-E--A-TS-PKA-NK-E-IL-D----EAYVMASV--D---NPHVCRLLGICL-------------TSTVQLITQLMPFGCLLDYVR-----EH-----------------------KDNI--GSQYLLNWCVQIAKGMNYLEDR--------RLVHRDLAARNVLVK-T-----PQHV-KITDFGLAKLL-----G---A--EEKE--------------YHAEGGKVPIKWMALESIL------HRIYTHQSDVWSYGVTVWELMTFGS----------KP---------------YDGI-----PASEISSIL----EK----GER---LPQPPICT-------------------------------IDVYM-IMVKCWMIDADSRPK-------FRELI----IEF------------
--V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREIYVAIKTL---K-A--G-YS-EKQ-RR-D-FL-S----EASIMGQF--D---HPNIIRLEGVVT--K----------SRPVMIITEFMENGALDSFLR-----QN-----------------------DGQF--TVIQLVGMLRGIAAGMKYLAEM--------NYVHRDLAARNILVN-S-----NLVC-KVSDFGLSRYLQ--DDT---S--DPTY--------------TSSLGGKIPVRWTAPEAIA------YRKFTSASDVWSYGIVMWEVMSFGE----------RP---------------YWDM-----SNQDVINAI----EQ----DYR---LPPPMDCP-------------------------------AALHQ-LMLDCWQKDRNSRPR-------FAEIVNTL----------------
--V-KIEQVIGAGEFGEVCSGHLK-------------LPGKREIFVAIKTL---K-S--G-YT-EKQ-RR-D-FL-S----EASIMGQF--D---HPNVIHLEGVVT--K----------STPVMIITEFMENGSLDSFLR-----QN-----------------------DGQF--TVIQLVGMLRGIAAGMKYLADM--------NYVHRDLAARNILVN-S-----NLVC-KVSDFGLSRFLE--DDT---S--DPTY--------------TSALGGKIPIRWTAPEAIQ------YRKFTSASDVWSYGIVMWEVMSYGE----------RP---------------YWDM-----TNQDVINAI----EQ----DYR---LPPPMDCP-------------------------------SALHQ-LMLDCWQKDRNHRPK-------FGQIVNTL----------------
--V-KIEEVIGAGEFGEVCRGRLK-------------APGKKESCVAIKTL---K-G--G-YT-ERQ-RR-E-FL-S----EASIMGQF--E---HPNIIRLEGVVT--N----------SMPVMILTEFMENGALDSFLR-----LN-----------------------DGQF--TVIQLVGMLRGIASGMRYLAEM--------SYVHRDLAARNILVN-S-----NLVC-KVSDFGLSRFLE--ENS---S--DPTY--------------TSSLGGKIPIRWTAPEAIA------FRKFTSASDAWSYGIVMWEVMSFGE----------RP---------------YWDM-----SNQDVINAI----EQ----DYR---LPPPPDCP-------------------------------TSLHQ-LMLDCWQKDRNARPR-------FPQVVSAL----------------
---IKIEEVIGTGSFGEVRQGRLQ-------------PRGRREQTVAIQAL---W-A--G-GA-ESL-QM-T-FL-G----RAAVLGQF--Q---HPNILRLEGVVT--K----------SRPLMVLTEFMELGPLDSFLR-----QR-----------------------EGQF--SSLQLVAMQRGVAAAMQYLSSF--------AFVHRSLSAHSVLVN-S-----HLVC-KVARLGHSPQG-----------------------------------PSCLLRWAAPEVIA------HGKHTTSSDVWSFGILMWEVMSYGE----------RP---------------YWDM-----SEQEVLNAI----EQ----EFR---LPPPPGCP-------------------------------PGLHL-LMLDTWQKDRARRPH-------FDQLVA---AF-------------
--L-KRVKVLGSGAFGTVYKGIWVP------------EGETVKIPVAIKIL---N-E--T-TG-PKA-NV-E-FM-D----EALIMASM--D---HPHLVRLLGVCL-------------SPTIQLVTQLMPHGCLLEYVH-----EH-----------------------KDNI--GSQLLLNWCVQIAKGMMYLEER--------RLVHRDLAARNVLVK-S-----PNHV-KITDFGLARLL-----E---G--DEKE--------------YNADGGKMPIKWMALECIH------YRKFTHQSDVWSYGVTIWELMTFGG----------KP---------------YDGI-----PTREIPDLL----EK----GER---LPQPPICT-------------------------------IDVYM-VMVKCWMIDADSRPK-------FKELAAE--F--------------
---LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAVKML---K-D--D-AT-EKD-LS-D-LV-S----EMEMMKMIG-K---HKNIINLLGACT--Q----------DGPLYVIVEYASKGNLREYLR-----ARRPPGMEY--------SYDINRVPEEQM--TFKDLVSCTYQLARGMEYLASQ--------KCIHRDLAARNVLVT-E-----NNVM-KIADFGLARDI-----N---N--IDYY--------------KKTTNGRLPVKWMAPEALF------DRVYTHQSDVWSFGVLMWEIFTLGG----------SP---------------YPGI-----PVEELFKLL----KE----GHR---MDKPANCT-------------------------------NELYM-MMRDCWHAVPSQRPT-------FKQLVEDL----------------
---LTLGKPLGEGCFGQVVMAEAIGI---------DKDRAAKPVTVAVKML---K-D--D-AT-DKD-LS-D-LV-S----EMEMMKMIG-K---HKNIINLLGACT--Q----------GGPLYVLVEYAAKGNLREFLR-----ARRPPGLDY--------SFDTCKPPEEQL--TFKDLVSCAYQVARGMEYLASQ--------KCIHRDLAARNVLVT-E-----DNVM-KIADFGLARDV-----H---N--LDYY--------------KKTTNGRLPVKWMAPEALF------DRVYTHQSDVWSFGVLLWEIFTLGG----------SP---------------YPGI-----PVEELFKLL----KE----GHR---MDKPANCT-------------------------------HDLYM-IMRECWHAAPSQRPT-------FKQLVEDL----------------
--L-VLGKPLGEGCFGQVVRAEAFGM---------DPARPDQASTVAVKML---K-D--N-AS-DKD-LA-D-LV-S----EMEVMKLIG-R---HKNIINLLGVCT--Q----------EGPLYVIVECAAKGNLREFLR-----ARRPPGPDL--------SPDGPRSSEGPL--SFPVLVSCAYQVARGMQYLESR--------KCIHRDLAARNVLVT-E-----DNVM-KIADFGLARGV-----H---H--IDYY--------------KKTSNGRLPVKWMAPEALF------DRVYTHQSDVWSFGILLWEIFTLGG----------SP---------------YPGI-----PVEELFSLL----RE----GHR---MDRPPHCP-------------------------------PELYG-LMRECWHAAPSQRPT-------FKQLVEAL----------------
---LKLEKKLGAGQFGEVWMATYN-----------------KHTKVAVKTM---K-P--G-SM-SV---E-A-FL-A----EANVMKTL--Q---HDKLVKLHAVVT-------------KEPIYIITEFMAKGSLLDFLK-----SD----------------------EGSKQ--PLPKLIDFSAQIAEGMAFIEQR--------NYIHRDLRAANILVS-A-----SLVC-KIADFGLARVI---------E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGSFTIKSDVWSFGILLMEIVTYGR----------IP---------------YPGM-----SNPEVIRAL----ER----GYR---MPRPENCP-------------------------------EELYN-IMMRCWKNRPEERPT-------FEYIQSV--L--------------
---ITMSRELGQGSFGMVYEGVAKG-----------VVKDEPETRVAIKTV---N-E--A-AS-MRE-RI-E-FL-N----EASVMKEF--N---CHHVVRLLGVVS--Q----------GQPTLVIMELMTRGDLKSYLR-----SLRPEM--------------ENNPVLAPP--SLSKMIQMAGEIADGMAYLNAN--------KFVHRDLAARNCMVA-E-----DFTV-KIGDFGMTRDI-----Y---E--TDYY--------------RKGGKGLLPVRWMSPESLK------DGVFTTYSDVWSFGVVLWEIATLAE----------QP---------------YQGL-----SNEQVLRFV----ME----GGL---LDKPDNCP-------------------------------DMLFE-LMRMCWQYNPKMRPS-------FLEIISS--I--------------
---ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAVKTV---N-E--S-AS-LRE-RI-E-FL-N----EASVMKGF--T---CHHVVRLLGVVS--K----------GQPTLVVMELMAHGDLKSYLR-----SLRPEA--------------ENNPGRPPP--TLQEMIQMAAEIADGMAYLNAK--------KFVHRDLAARNCMVA-H-----DFTV-KIGDFGMTRDI-----Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK------DGVFTTSSDMWSFGVVLWEITSLAE----------QP---------------YQGL-----SNEQVLKFV----MD----GGY---LDQPDNCP-------------------------------ERVTD-LMRMCWQFNPKMRPT-------FLEIVNLL----------------
--I-SIIRELGQGSFGMVYEGLARG-----------LEAGEESTPVALKTV---N-E--L-AS-PRE-CI-E-FL-K----EASVMKAF--K---CHHVVRLLGVVS--Q----------GQPTLVIMELMTRGDLKSHLR-----SLRPEA--------------ENNPGLPQP--ALGEMIQMAGEIADGMAYLAAN--------KFVHRDLAARNCMVS-Q-----DFTV-KIGDFGMTRDV-----Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK------DGIFTTHSDVWSFGVVLWEIVTLAE----------QP---------------YQGL-----SNEQVLKFV----MD----GGV---LEELEGCP-------------------------------LQLQE-LMSRCWQPNPRLRPS-------FTHILD---SI-------------
VGG----NKMGEGGFGVVYKGYVN----------------NTT--VAVKKL---AAM--V-DITTE---ELK-QQFD---QEIKVMAKC--Q---HENLVELLGFSS--D----------GDDLCLVYVYMPNGSLLDRLSC-LDGTP-------------------------PL--SWHMRCKIAQGAANGINFLHEN--------HHIHRDIKSANILLD-E-----AFTA-KISDFGLARASE-------KFAQTVMT--------------SR---IVGTTAYMAPEALR-------GEITPKSDIYSFGVVLLEIIT-GL----------PA---------------VDEH-----REPQLLLDI----KE----EIE---DEEKTIEDYIDKKMNDAD-----------------STSVEAMYS-VASQCLHEKKNKRPD-------IKKVQQ----LLQ-----------
---LTFVQEIGSGQFGLVHLGYWL-----------------NKDKVAIKTI---R-E--G-AM-SE---E-D-FI-E----EAEVMMKL--S---HPKLVQLYGVCL--E----------QAPICLVFEFMEHGCLSDYLR-----TQ-----------------------RGLF--AAETLLGMCLDVCEGMAYLEEA--------CVIHRDLAARNCLVG-E-----NQVI-KVSDFGMTRFV---------L--DDQY--------------TSSTGTKFPVKWASPEVFS------FSRYSSKSDVWSFGVLMWEVFSEGK----------IP---------------YENR-----SNSEVVEDI----ST----GFR---LYKPRLAS-------------------------------THVYQ-IMNHCWKERPEDRPA-------FSRLLRQL----------------
---LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAVKKL---Q-H--S-TE--EH-LR-D-FE-R----EIEILKSL--Q---HDNIVKYKGVCYSAG----------RRNLKLIMEYLPYGSLRDYLQ-----KH-----------------------KERI--DHIKLLQYTSQICKGMEYLGTK--------RYIHRDLATRNILVE-N-----ENRV-KIGDFGLTKVL----PQ---D--KEYY--------------KVKEPGESPIFWYAPESLT------ESKFSVASDVWSFGVVLYELFTYIE----------KSKSPPAEFMRMIGNDKQGQM-----IVFHLIELL----KN----NGR---LPRPDGCP-------------------------------DEIYM-IMTECWNNNVNQRPS-------FRDLA----LRV------------
--V-TLLRALGHGAFGEVYEGLVIG-----------LPGDSSPLQVAIKTL---P-E--L-CS-PQD-EL-D-FL-M----EALIISKF--R---HQNIVRCVGLSL--R----------ATPRLILLELMSGGDMKSFLR-----HSRP-----------------HLGQPSPL--VMRDLLQLAQDIAQGCHYLEEN--------HFIHRDIAARNCLLS-CA--GPSRVA-KIGDFGMARDI-----Y---R--ASYY--------------RRGDRALLPVKWMPPEAFL------EGIFTSKTDSWSFGVLLWEIFSLGY----------MP---------------YPGR-----TNQEVLDFV----VG----GGR---MDPPRGCP-------------------------------GPVYR-IMTQCWQHEPELRPS-------FASILERL----------------
---IKLVKRLGAGQFGEVWMGYYN-----------------NSTKVAVKTL---K-P--G-TM-SV---Q-A-FL-E----EANLMKTL--Q---HDKLVRLYAVVT--R----------EEPIYIITEYMAKGSLLDFLK-----SD----------------------EGGKV--LLPKLIDFSAQIAEGMAYIERK--------NYIHRDLRAANVLVS-E-----SLMC-KIADFGLARVI---------E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGCFTIKSDVWSFGILLYEIVTYGK----------IP---------------YPGR-----TNADVMTAL----SQ----GYR---MPRVENCP-------------------------------DELYD-IMKMCWKEKAEERPT-------FDYLQSV--L--------------
ERV-----VLGKGTYGIVYAGRDL----------------SNQVRIAIKEI---PER--D-SRYSQ---P-L-H--E----EIALHKYL--K---HRNIVQYLGSVS--E----------NGYIKIFMEQVPGGSLSALLR---SKWG-------------------------PM--KEPTIKFYTKQILEGLKYLHEN--------QIVHRDIKGDNVLVNTY-----SGVV-KISDFGTSKRL---------AGVNPCT--------------ET---FTGTLQYMAPEIID----QGPRGYGAPADIWSLGCTIIEMAT-SK----------PP---------------FHEL-------GEPQAAM----FK----VGM---FKIHPEIPEALS---------------------------AEARA-FILSCFEPDPHKRAT-------TAELLREGF-L-------------
---WRLGKLLGQGAFGRVYLCYDV----------------DTGRELAVKQV---QFD--P-DSPET---S-K-EVNAL-ECEIQLLKNL--L---HERIVQYYGCLR--DP--------QEKTLSIFMEYMPGGSIKDQLK----AYG-------------------------AL--TENVTRKYTRQILEGVHYLHSN--------MIVHRDIKGANILRD-S-----TGNV-KLGDFGASKRLQ------TICLSGTGM--------------KS---VTGTPYWMSPEVIS------GEGYGRKADIWSVACTVVEMLT-EK----------PP---------------WAEF--------EAMAAI----FK----IAT---QPTNPKLPPHVS---------------------------DYTRD-FLKRIFV-EAKLRPS-------ADELLRHMF-V-------------
--W-RRGKLLGQGAFGRVYLCYDV----------------DTGRELASKQV---QFD--P-DSPET---S-K-EVSAL-ECEIQLLKNL--Q---HERIVQYYGCLR--DR--------AEKTLTIFMEYMPGGSVKDQLK----AYG-------------------------AL--TESVTRKYTRQILEGMSYLHSN--------MIVHRDIKGANILRD-S-----AGNV-KLGDFGASKRLQ------TICMSGTGM--------------RS---VTGTPYWMSPEVIS------GEGYGRKADVWSLGCTVVEMLT-EK----------PP---------------WAEY--------EAMAAI----FK----IAT---QPTNPQLPSHIS---------------------------EHGRD-FLRRIFV-EARQRPS-------AEELLTHHF-A-------------
DRV-----VLGKGTYGIVYAGRDL----------------SNQVRIAIKEI---PER--D-SRYSQ---P-L-H--E----EIALHKHL--K---HKNIVQYLGSFS--E----------NGFIKIFMEQVPGGSLSALLR---SKWG-------------------------PLKDNEQTIGFYTKQILEGLKYLHDN--------QIVHRDIKGDNVLINTY-----SGVL-KISDFGTSKRL---------AGINPCT--------------ET---FTGTLQYMAPEIID----KGPRGYGKAADIWSLGCTIIEMAT-GK----------PP---------------FYEL-------GEPQAAM----FK----VGM---FKVHPEIPESMS---------------------------AEAKA-FILKCFEPDPDKRAC-------ANDLLVDEF-L-------------
ERL-----VLGKGTYGVVYAGRDR----------------HTRVRIAIKEI---PER--D-SRFSQ---P-L-H--E----EIALHRRL--R---HKNIVRYLGSAS--Q----------GGYLKIFMEEVPGGSLSSLLR---SVWG-------------------------PLKDNESTISFYTRQILQGLGYLHDN--------HIVHRDIKGDNVLINTF-----SGLL-KISDFGTSKRL---------AGITPCT--------------ET---FTGTLQYMAPEIID----QGPRGYGKAADIWSLGCTVIEMAT-GR----------PP---------------FHEL-------GSPQAAM----FQ----VGM---YKVHPPMPSSLS---------------------------AEAQA-FLLRTFEPDPRLRAS-------AQTLLGDPFL--------------
---LTLGAQIGEGEFGAVLQGEYL------------------GQKVAVKNI---K-C--D-VT-AQ-----A-FL-D----ETAVMTKM--Q---HENLVRLLGVIL-------------HQGLYIVMEHVSKGNLVNFLR-----TR----------------------GRALV--NTAQLLQFSLHVAEGMEYLESK--------KLVHRDLAARNILVS-E-----DLVA-KVSDFGLAKAE---------------R--------------KGLDSSRLPVKWTAPEALK------HGKFTSKSDVWSFGVLLWEVFSYGR----------AP---------------YPKM-----SLKEVSEAV----EK----GYR---MEPPEGCP-------------------------------GPVHV-LMSSCWEAEPARRPP-------FRKLAEKL----------------
--I-EYVRDIGEGAFGRVFQARAPG-----------LLPYEPFTMVAVKML---K-E--E-AS-ADM-QA-D-FQ-R----EAALMAEF--D---NPNIVKLLGVCA--V----------GKPMCLLFEYMAYGDLNEFLR-----SMSPHTVCSLSHSDLSMRAQVSSPGPPPL--SCAEQLCIARQVAAGMAYLSER--------KFVHRDLATRNCLVG-E-----NMVV-KIADFGLSRNI-----Y---S--ADYY--------------KANENDAIPIRWMPPESIF------YNRYTTESDVWAYGVVLWEIFSYGL----------QP---------------YYGM-----AHEEVIYYV----RD----GNI---LSCPENCP-------------------------------VELYN-LMRLCWSKLPADRPS-------FTSIHRIL----------------
--Y-VRLQKIGEGSFGKAILVKST----------------EDGRQYVIKEI---NIS--R-MSSKE---R-E-ESRR----EVAVLANM--K---HPNIVQYRESFE--E----------NGSLYIVMDYCEGGDLFKRINA--QKGV-------------------------LF--QEDQILDWFVQICLALKHVHDR--------KILHRDIKSQNIFLT-K-----DGTV-QLGDFGIARVL---------NSTVELA--------------RT---CIGTPYYLSPEICE------NKPYNNKSDIWALGCVLYELCT-LK----------HA---------------FEAG--------SMKNLV----LK----IIS---GSFPPVSLHYS----------------------------YDLRS-LVSQLFKRNPRDRPS-------VNSILEKGF-I-------------
---YEVLYTIGTGSYGRCQKIRRK----------------SDGKILVWKEL---DYG--S-MTEAE---K-Q-MLVS----EVNLLREL--K---HPNIVRYYDRII--DR--------TNTTLYIVMEYCEGGDLASVITKGTKERQ-------------------------YL--DEEFVLRVMTQLTLALKECHRRSD---GGHTVLHRDLKPANVFLD-G-----KQNV-KLGDFGLARIL---------NHDTSFA--------------KT---FVGTPYYMSPEQMN------RMSYNEKSDIWSLGCLLYELCA-LM----------PP---------------FTAF--------SQKELA----GK----IRE---GKFRRIPYRY---S-------------------------DELNE-IITRMLNLKDYHRPS-------VEEILENPL-I-------------
--Y-CYLRVVGKGSYGEVTLVKHR----------------RDGKQYVIKKL---NLR--N-ASSRE---R-R-AAEQ----EAQLLSQL--K---HPNIVTYKESWE--G---------GDGLLYIVMGFCEGGDLYRKLKE--QKGQ-------------------------LL--PENQVVEWFVQIAMALQYLHEK--------HILHRDLKTQNVFLT-R-----TNII-KVGDLGIARVL---------ENHCDMA--------------ST---LIGTPYYMSPELFS------NKPYNYKSDVWALGCCVYEMAT-LK----------HA---------------FNAK--------DMNSLV----YR----IIE---GKLPPMPRDY---S-------------------------PELAE-LIRTMLSKRPEERPS-------VRSILRQPYI--------------
---YDVIKAIGQGAFGKAYLAKGK----------------SDSKHCVIKEI---NFE--K-MPIQE---K-E-ASKK----EVILLEKM--K---HPNIVAFFNSFQ--E----------NGRLFIVMEYCDGGDLMKRINR--QRGV-------------------------LF--SEDQILGWFVQISLGLKHIHDR--------KILHRDIKAQNIFLS-K-----NGMVAKLGDFGIARVL---------NNSMELA--------------RT---CIGTPYYLSPEICQ------NKPYNNKTDIWSLGCVLYELCT-LK----------HP---------------FEGN--------NLQQLV----LK----ICQ---AHFAPISPGF---S-------------------------RELHS-LISQLFQVSPRDRPS-------INSILKRPFL--------------
---YERIRVVGRGAFGIVHLCLRK----------------ADQKLVIIKQI---PVE--Q-MTKEE---R-Q-AAQN----ECQVLKLL--N---HPNVIEYYENFL--E----------DKALMIAMEYAPGGTLAEFIQK--RCNS-------------------------LL--EEETILHFFVQILLALHHVHTH--------LILHRDLKTQNILLDKH-----RMVV-KIGDFGISKI----------LSSKSKA--------------YT---VVGTPCYISPELCE------GKPYNQKSDIWALGCVLYELAS-LK----------RA---------------FEAA--------NLPALV----LK----IMS---GTFAPISDRY---S-------------------------PELRQ-LVLSLLSLEPAQRPP-------LSHIMAQP--LC------------
-IV--LKWELGEGAFGKVFLAECHN-----------LLPEQDKMLVAVKAL---K-E--A-SE-SA--RQ-D-FQ-R----EAELLTML--Q---HQHIVRFFGVCT--E----------GRPLLMVFEYMRHGDLNRFLR-----SHGPDAKL---------LAGGEDVAPGPL--GLGQLLAVASQVAAGMVYLAGL--------HFVHRDLATRNCLVG-Q-----GLVV-KIGDFGMSRDI-----Y---S--TDYY--------------RVGGRTMLPIRWMPPESIL------YRKFTTESDVWSFGVVLWEIFTYGK----------QP---------------WYQL-----SNTEAIDCI----TQ----GRE---LERPRACP-------------------------------PEVYA-IMRGCWQREPQQRHS-------IKDVHARL----------------
--I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKILVAVKTL---K-D--A-SD-NA--RK-D-FH-R----EAELLTNL--Q---HEHIVKFYGVCV--E----------GDPLIMVFEYMKHGDLNKFLR-----AHGPDAV-----------LMAEGNPPTEL--TQSQMLHIAQQIAAGMVYLASQ--------HFVHRDLATRNCLVG-E-----NLLV-KIGDFGMSRDV-----Y---S--TDYY--------------RVGGHTMLPIRWMPPESIM------YRKFTTESDVWSLGVVLWEIFTYGK----------QP---------------WYQL-----SNNEVIECI----TQ----GRV---LQRPRTCP-------------------------------QEVYE-LMLGCWQREPHMRKN-------IKGIHTL--L--------------
--I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKMLVAVKAL---K-D--P-TL-AA--RK-D-FQ-R----EAELLTNL--Q---HEHIVKFYGVCG--D----------GDPLIMVFEYMKHGDLNKFLR-----AHGPDAMIL--------VDGQPRQAKGEL--GLSQMLHIASQIASGMVYLASQ--------HFVHRDLATRNCLVG-A-----NLLV-KIGDFGMSRDV-----Y---S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM------YRKFTTESDVWSFGVILWEIFTYGK----------QP---------------WFQL-----SNTEVIECI----TQ----GRV---LERPRVCP-------------------------------KEVYD-VMLGCWQREPQQRLN-------IKEIYKIL----------------
--F-KFGKILGEGSFSTVVLAREL----------------ATSREYAIKIL---EKR--H-IIKEN---K-VPYVTR----ERDVMSRL--D---HPFFVKLYFTFQ--D----------DEKLYFGLSYAKNGELLKYIR----KIG-------------------------SF--DETCTRFYTAEIVSALEYLHGK--------GIIHRDLKPENILLN-E-----DMHI-QITDFGTAKVLS-------PESKQARA--------------NS---FVGTAQYVSPELLT------EKSACKSSDLWALGCIIYQLVA-GL----------PP---------------FRAG--------NEYLIF----QK----IIK---LEYDFPEKFF-----------------------------PKARD-LVEKLLVLDATKRLG-------CEEM------EGYGPLKAHPF---
--F-KFLAVLGRGHFGKVLLSEFR----------------PSGELFAIKAL---KKG--D-IVARD---E-V-ESLM---CEKRILAAV--TSAGHPFLVNLFGCFQ--T----------PEHVCFVMEYSAGGDLMLHIH-----SD-------------------------VF--SEPRAIFYSACVVLGLQFLHEH--------KIVYRDLKLDNLLLD-T-----EGYV-KIADFGLCKEG---------MGYGDRT--------------ST---FCGTPEFLAPEVLT------DTSYTRAVDWWGLGVLLYEMLV-GE----------SP---------------FPGD--------DEEEVF----DS----IVN---DEVRYPRFLS-----------------------------AEAIG-IMRRLLRRNPERRLGSS--ERDAEDVKKQPFF--------------
--F-ERIKTLGTGSFGRVMLVKHK----------------ETGNHYAMKIL---DKQ--K-VVKLK---Q-I-EHTL---NEKRILQAV--N---FPFLVKLEFSFK--D----------NSNLYMVMEYVPGGEMFSHLR----RIG-------------------------RF--SEPHARFYAAQIVLTFEYLHSL--------DLIYRDLKPENLLID-Q-----QGYI-QVTDFGFAK------------RVKGRT--------------WT---LCGTPEYLAPEIIL------SKGYNKAVDWWALGVLIYEMAA-GY----------PP---------------FFAD--------QPIQIY----EK----IVS---GKVRFPSHFS-----------------------------SDLKD-LLRNLLQVDLTKRFGNL--KNGVNDIKNHKWF--------------
---FERLRTLGMGSFGRVMLVRHQ----------------ETGGHYAMKIL---NKQ--K-VVKMK---Q-V-EHIL---NEKRILQAI--D---FPFLVKLQFSFK--D----------NSYLYLVMEYVPGGEMFSRLQ----RVG-------------------------RF--SEPHACFYAAQVVLAVQYLHSL--------DLIHRDLKPENLLID-Q-----QGYL-QVTDFGFAK------------RVKGRT--------------WT---LCGTPEYLAPEIIL------SKGYNKAVDWWALGVLIYEMAV-GF----------PP---------------FYAD--------QPIQIY----EK----IVS---GRVRFPSKLS-----------------------------SDLKH-LLRSLLQVDLTKRFGNL--RNGVGDIKNHKWF--------------
--F-NFLMVLGKGSFGKVMLADRK----------------GTEELYAIKIL---KKD--V-VIQDD---D-V-ECTM---VEKRVLALL-DK---PPFLTQLHSCFQ--T----------VDRLYFVMEYVNGGDLMYHIQ----QVG-------------------------KF--KEPQAVFYAAEISIGLFFLHKR--------GIIYRDLKLDNVMLD-S-----EGHI-KIADFGMCKEH---------MMDGVTT--------------RT---FCGTPDYIAPEIIA------YQPYGKSVDWWAYGVLLYEMLA-GQ----------PP---------------FDGE--------DEDELF----QS----IME---HNVSYPKSLS-----------------------------KEAVS-VCKGLMTKHPAKRLG-------C---------GPEGERDVREHAFF
--F-NFIKVLGKGSFGKVMLAELK----------------GKDEVYAVKVL---KKD--V-ILQDD---D-V-DCTM---TEKRILALA-RK---HPYLTQLYCCFQ--T----------KDRLFFVMEYVNGGDLMFQIQ----RSR-------------------------KF--DEPRSRFYAAEVTSALMFLHQH--------GVIYRDLKLDNILLD-A-----EGHC-KLADFGMCKEG---------ILNGVTT--------------TT---FCGTPDYIAPEILQ------ELEYGPSVDWWALGVLMYEMMA-GQ----------PP---------------FEAD--------NEDDLF----ES----ILH---DDVLYPVWLS-----------------------------KEAVS-ILKAFMTKNPHKRLGCVASQNGEDAIKQHP--FF------------
-FD--TLATVGTGTFGRVHLVKEK----------------TAKHFFALKVM---SIP--D-VIRLK---Q-E-QHVH---NEKSVLKEV--S---HPFLIRLFWTWH--D----------ERFLYMLMEYVPGGELFSYLR----NRG-------------------------RF--SSTTGLFYSAEIICAIEYLHSK--------EIVYRDLKPENILLD-R-----DGHI-KLTDFGFAKK------------LVDRT--------------WT---LCGTPEYLAPEVIQ------SKGHGRAVDWWALGILIFEMLS-GF----------PP---------------FFDD--------NPFGIY----QK----ILA---GKIDFPRHLD-----------------------------FHVKD-LIKKLLVVDRTRRLGNM--KNGANDVKHHRWF--------------
---IELGRCIGEGQFGDVHQGIYM-------------SPENPALAVAIKTC---K-N--C-TS-DSV-RE-K-FL-Q----EALTMRQF--D---HPHIVKLIGVIT-------------ENPVWIIMELCTLGELRSFLQ-----VR-----------------------KYSL--DLASLILYAYQLSTALAYLESK--------RFVHRDIAARNVLVS-S-----NDCV-KLGDFGLSRYM---------E--DSTY--------------YKASKGKLPIKWMAPESIN------FRRFTSASDVWMFGVCMWEILMHGV----------KP---------------FQGV-----KNNDVIGRI----EN----GER---LPMPPNCP-------------------------------PTLYS-LMTKCWAYDPSRRPR-------FTELKAQL----------------
-LT--LRLLLGSGAFGEVYEGTAVDI----------LGVGSGEIKVAVKTL---K-K--G-ST-DQE-KI-E-FL-K----EAHLMSKF--N---HPNILKQLGVCL--L----------NEPQYIILELMEGGDLLTYLR-----KARM-----------------ATFYGPLL--TLVDLVDLCVDISKGCVYLERM--------HFIHRDLAARNCLVS-VKDYTSPRIV-KIGDFGLARDI-----Y---K--NDYY--------------RKRGEGLLPVRWMAPESLM------DGIFTTQSDVWSFGILIWEILTLGH----------QP---------------YPAH-----SNLDVLNYV----QT----GGR---LEPPRNCP-------------------------------DDLWN-LMTQCWAQEPDQRPT-------FHRIQDQL----------------
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAIKTL---K-P--G-TM-SP---E-A-FL-Q----EAQVMKKL--R---HEKLVQLYAVVS-------------EEPIYIVTEYMSKGSLLDFLK-----GE----------------------TGKYL--RLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVG-E-----NLVC-KVADFGLARLI---------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELTTKGR----------VP---------------YPGM-----VNREVLDQV----ER----GYR---MPCPPECP-------------------------------ESLHD-LMCQCWRKEPEERPT-------FEYLQAF--L--------------
--F-DVLEKLGEGSYGSVFKAIHK----------------ESGQVVAIKQV---PVE--S-DLQEI---------IK----EISIMQQC--D---SPYVVKYYGSYF--K----------NTDLWIVMEYCGAGSVSDIIR---LRNK-------------------------TL--IEDEIATILKSTLKGLEYLHFM--------RKIHRDIKAGNILLN-T-----EGHA-KLADFGVAGQL---------TDTMAKR--------------NT---VIGTPFWMAPEVIQ------EIGYNCVADIWSLGITSIEMAE-GK----------PP---------------YADI-----HPMRAIFMI----PT----NPP---PTFRKPELWS-----------------------------DDFTD-FVKKCLVKNPEQRAT-------ATQLLQHPFI--------------
--F-DVLEKLGEGSYGSVYKAIHK----------------ETGQIVAIKQV---PVE--S-DLQEI---------IK----EISIMQQC--D---SPHVVKYYGSYF--K----------NTDLWIVMEYCGAGSVSDIIR---LRNK-------------------------TL--TEDEIATILQSTLKGLEYLHFM--------RKIHRDIKAGNILLN-T-----EGHA-KLADFGVAGQL---------TDTMAKR--------------NT---VIGTPFWMAPEVIQ------EIGYNCVADIWSLGITAIEMAE-GK----------PP---------------YADI-----HPMRAIFMI----PT----NPP---PTFRKPELWS-----------------------------DNFTD-FVKQCLVKSPEQRAT-------ATQLLQHPFV--------------
TLE---DKELGSGNFGTVKKGYYQ--------------MKKVVKTVAVKIL---K-N--E-AN-DPALKD-E-LL-A----EANVMQQL--D---NPYIVRMIGICE-------------AESWMLVMEMAELGPLNKYLQ-----QN------------------------RHV--KDKNIIELVHQVSMGMKYLEES--------NFVHRDLAARNVLLV-T-----QHYA-KISDFGLSKAL-----R---A--DENY-------------YKAQTHGKWPVKWYAPECIN------YYKFSSKSDVWSFGVLMWEAFSYGQ----------KP---------------YRGM-----KGSEVTAML----EK----GER---MGCPAGCP-------------------------------REMYD-LMNLCWTYDVENRPG-------FAAVE----LRL------------
-FS--DLREIGHGSFGAVYFARDV----------------RNSEVVAIKKM---SYS--G-KQSNE---K-W-QDII---KEVRFLQKL--R---HPNTIQYRGCYL--R----------EHTAWLVMEYCLG-SASDLLE---VHKK-------------------------PL--QEVEIAAVTHGALQGLAYLHSH--------NMIHRDVKAGNILLS-E-----PGLV-KLGDFGSASI-------------MAPA--------------NS---FVGTPYWMAPEVILA---MDEGQYDGKVDVWSLGITCIELAE-RK----------PP---------------LFNM-----NAMSALYHI----AQ----NES---PVLQSGHWS------------------------------EYFRN-FVDSCLQKIPQDRPT-------SEVLLKHRFV--------------
---LTFMRELGSGLFGVVRLGKWR-----------------AQYKVAIKAI---R-E--G-AM-CE---E-D-FI-E----EAKVMMKL--T---HPKLVQLYGVCT--Q----------QKPIYIVTEFMERGCLLNFLR-----QR-----------------------QGHF--SRDVLLSMCQDVCEGMEYLERN--------SFIHRDLAARNCLVS-E-----AGVV-KVSDFGMARYV---------L--DDQY--------------TSSSGAKFPVKWCPPEVFN------YSRFSSKSDVWSFGVLMWEVFTEGR----------MP---------------FEKY-----TNYEVVTMV----TR----GHR---LYQPKLAS-------------------------------NYVYE-VMLRCWQEKPEGRPS-------FEDLLRT--I--------------
-IV--LQESIGKGRFGEVWRGKWR----------------GEE--VAVKIF---SSR--E-ERSWF---R-E-A-------EIYQTVML--R---HENILGFIAADN--KDN------GTWTQLWLVSDYHEHGSLFDYLN-----RY-------------------------TV--TVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVK-K-----NGTC-CIADLGLAVRHDS-----ATDTIDIAP--------------NH---RVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIAR-RCSIGGIHEDYQLP---------------YYDLVPSDPSVEEMRKVV----CE----QKL---RPNIPNRWQSCEAL-------------------------RVMAK-IMRECWYANGAARLT-------ALRIKK----TL------------
VCR---GELLGSGCFGVVHRGLWT-------------LPSGKSVPVAVKSLRVGP-E--G-PM-GTE-LG-D-FL-R----EVSVMMNL--E---HPHVLRLHGLVL-------------GQPLQMVMELAPLGSLHARLT-----AP---------------------APTPPL--LVALLCLFLRQLAGAMAYLGAR--------GLVHRDLATRNLLLA-S-----PRTI-KVADFGLVRPL----GG---A--RGRY--------------VMGGPRPIPYAWCAPESLR------HGAFSSASDVWMFGVTLWEMFSGGE----------EP---------------WAGV-----PPYLILQRL----ED----RAR---LPRPPLCS-------------------------------RALYS-LALRCWAPHPADRPS-------FSHLE----GLL------------
--L-RLLEKLGDGSFGVVRRGEWD-------------APSGKTVSVAVKCL---K-PDVL-SQ-PEA-MD-D-FI-R----EVNAMHSL--D---HRNLIRLYGVVL-------------TPPMKMVTELAPLGSLLDRLR-----KH-----------------------QGHF--LLGTLSRYAVQVAEGMGYLESK--------RFIHRDLAARNLLLA-T-----RDLV-KIGDFGLMRAL----PQ---N--DDHY--------------VMQEHRKVPFAWCAPESLK------TRTFSHASDTWMFGVTLWEMFTYGQ----------EP---------------WIGL-----NGSQILHKI---DKE----GER---LPRPEDCP-------------------------------QDIYN-VMVQCWAHKPEDRPT-------FVALRDF--L--------------
--L-AFIKEIGSGQFGVVHLGEWR-----------------SHIQVAIKAI---N-E--G-SM-SE---E-D-FI-E----EAKVMMKL--S---HSKLVQLYGVCI--Q----------RKPLYIVTEFMENGCLLNYLR-----EN-----------------------KGKL--RKEMLLSVCQDICEGMEYLERN--------GYIHRDLAARNCLVS-S-----TCIV-KISDFGMTRYV---------L--DDEY--------------VSSFGAKFPIKWSPPEVFL------FNKYSSKSDVWSFGVLMWEVFTEGK----------MP---------------FENK-----SNLQVVEAI----SE----GFR---LYRPHLAP-------------------------------MSIYE-VMYSCWHEKPEGRPT-------FAELLR---AV-------------
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAIKTL---K-P--G-TM-MP---E-A-FL-Q----EAQIMKKL--R---HDKLVPLYAVVS-------------EEPIYIVTEFMSKGSLLDFLK-----EG----------------------DGKYL--KLPQLVDMAAQIADGMAYIERM--------NYIHRDLRAANILVG-E-----NLVC-KIADFGLARLI---------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILQTELVTKGR----------VP---------------YPGM-----VNREVLEQV----ER----GYR---MPCPQGCP-------------------------------ESLHE-LMNLCWKKDPDERPT-------FEYIQSFL----------------
---WTKGEILGKGAYGTVYCGLTS----------------QGQ-LIAVKQV---ALD--T-SNKLA---A-E-KEYRKLQEEVDLLKAL--K---HVNIVAYLGTCL--Q----------ENTVSIFMEFVPGGSISSIIN----RFG-------------------------PL--PEMVFCKYTKQILQGVAYLHEN--------CVVHRDIKGNNVMLM-P-----TGII-KLIDFGCARRLAWA---GLNGTHSDML--------------KS---MHGTPYWMAPEVIN------ESGYGRKSDIWSIGCTVFEMAT-GK----------PP---------------LASM-------DRMAAMF----YI----GAH---RGLMPPLPDHFS---------------------------ENAAD-FVRMCLTRDQHERPS-------ALQLLKHSFL--------------
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