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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FRK 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
TK BLK 241
TK BMX 422
TKL BRAF 456
TK BTK 402
TK CSF1R 582
TK CSK 195
TK DDR1 572
TK EGFR 712
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB4 615
TK EPHB6 670
TK ERBB4 718
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FYN 271
TK HCK 241
TK INSR 1023
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK KIT 589
TK LCK 245
TK LTK 510
TK LYN 247
CAMK MARK2 53
CAMK MARK4 59
CAMK MGC42105 74
TK MUSK 575
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
CAMK NUAK2 97
TK PDGFRA 593
TK PDGFRB 600
TK PTK2 422
TK PTK6 191
TK RET 724
TK ROS1 1945
CAMK SIK2 20
TK SRC 270
TK SRMS 230
CAMK STK17A 61
STE STK25 20
TK SYK 371
TK TEC 370
Other TLK2 440
TK TNK1 116
TK TNK2 150
TK TXK 271
TK TYK2 589
TK YES1 277
TK ZAP70 338
----IQLLKRLGSGQFGEVWEGLWN-----------------NTTPVAVKTL---K-P--GSM-DP---NDFL-R-----EAQIMKNL--RHPKLIQLYAVCT--L-EDP--IYIITELMRHGSLQEYLQ---ND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESR--NYIHRDLAARNVLVGE-----HNIY---KVADFGLARVFK---VD----N--EDIY--------------ESRHEIKLPVKWTAPEAIR----SNK---FSIKSDVWSFGILLYEIITYGK-MP---------------YSGM-TGAQVIQML----AQNYR----LPQPSNCP------QQFYN-IMLECWNAEPKERPTFETLRWK--L--
----ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTL---K-E--DTM-EV---EEFL-K-----EAAVMKEI--KHPNLVQLLGVCT--R-EPP--FYIITEFMTYGNLLDYLR---EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK--NFIHRDLAARNCLVGE-----NHLV---KVADFGLSRLM----------T--GDTY--------------TAHAGAKFPIKWTAPESLA----YNK---FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQVYELL----EKDYR----MERPEGCP------EKVYE-LMRACWQWNPSDRPSFAEIHQA--F--
----ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTL---K-E--DTM-EV---EEFL-K-----EAAVMKEI--KHPNLVQLLGVCT--L-EPP--FYIVTEYMPYGNLLDYLR---EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKK--NFIHRDLAARNCLVGE-----NHVV---KVADFGLSRLM----------T--GDTY--------------TAHAGAKFPIKWTAPESLA----YNT---FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQVYDLL----EKGYR----MEQPEGCP------PKVYE-LMRACWKWSPADRPSFAETHQA--F--
---I-TLIRGLGHGAFGEVYEGQVSG-----------MPNDPSPLQVAVKTL---P-E--VCS-EQD-ELDFL-M-----EALIISKF--NHQNIVRCIGVSL--Q-SLP--RFILLELMAGGDLKSFLR---ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN--HFIHRDIAARNCLLTCP--GPGRVA---KIGDFGMARDI-----Y----R--ASYY--------------RKGGCAMLPVKWMPPEAFM----EGI---FTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK-SNQEVLEFV----TSGGR----MDPPKNCP------GPVYR-IMTQCWQHQPEDRPNFAIILER--I--
---L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAIKTL---K-E--GTM-SP---EAFL-G-----EANVMKAL--QHERLVRLYAVVT----KEP--IYIVTEYMARGCLLDFLK---TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERM--NSIHRDLRAANILVSE-----ALCC---KIADFGLARII-------------DSEY--------------TAQEGAKFPIKWTAPEAIH----FGV---FTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM-SNPEVIRNL----ERGYR----MPRPDTCP------PELYRGVIAECWRSRPEERPTFEFLQSV--L--
----ITLLKELGSGQFGVVQLGKWK-----------------GQYDVAVKMI---K-E--GSM-SE---DEFF-Q-----EAQTMMKL--SHPKLVKFYGVCS--K-EYP--IYIVTEYISNGCLLNYLR---SH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESH--QFIHRDLAARNCLVDR-----DLCV---KVSDFGMTRYV----------L--DDQY--------------VSSVGTKFPVKWSAPEVFH----YFK---YSSKSDVWAFGILMWEVFSLGK-QP---------------YDLY-DNSQVVLKV----SQGHR----LYRPHLAS------DTIYQ-IMYSCWHELPEKRPTFQQLLSS--I--
----ITVGQRIGSGSFGTVYKGKWH-------------------GDVAVKML---N-V-TAPT-PQQ-LQAFK-N-----EVGVLRKT--RHVNILLFMGYST----KPQ--LAIVTQWCEGSSLYHHLH---II--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAK--SIIHRDLKSNNIFLHE-----DLTV---KIGDFGLATVK-----S----R--WSGS--------------HQFEQLSGSILWMAPEVIR----MQDKNPYSFQSDVYAFGIVLYELMT-GQ-LP---------------YSNINNRDQIIFMV----GRGYLSPDLSKVRSNCP------KAMKR-LMAECLKKKRDERPLFPQILA---SI-
----LTFLKELGTGQFGVVKYGKWR-----------------GQYDVAIKMI---K-E--GSM-SE---DEFI-E-----EAKVMMNL--SHEKLVQLYGVCT--K-QRP--IFIITEYMANGCLLNYLR---EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESK--QFLHRDLAARNCLVND-----QGVV---KVSDFGLSRYV----------L--DDEY--------------TSSVGSKFPVRWSPPEVLM----YSK---FSSKSDIWAFGVLMWEIYSLGK-MP---------------YERF-TNSETAEHI----AQGLR----LYRPHLAS------EKVYT-IMYSCWHEKADERPTFKILLSN--I--
----LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAVKML---K-S--TAH-ADE-KEALM-S-----ELKIMSHLG-QHENIVNLLGACT--H-GGP--VLVITEYCCYGDLLNFLR---RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASK--NCIHRDVAARNVLLTN-----GHVA---KIGDFGLARDI-----M----N--DSNY--------------IVKGNARLPVKWMAPESIF----DCV---YTVQSDVWSYGILLWEIFSLGL-NP---------------YPGILVNSKFYKLV----KDGYQ----MAQPAFAP------KNIYS-IMQACWALEPTHRPTFQQICSFL----
----LKLLQTIGKGEFGDVMLGDYR------------------GNKVAVKCI---K-N--DAT-AQ----AFL-A-----EASVMTQL--RHSNLVQLLGVIV-EE-KGG--LYIVTEYMAKGSLVDYLR---SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGN--NFVHRDLAARNVLVSE-----DNVA---KVSDFGLTKEA----------------S--------------STQDTGKLPVKWTAPEALR----EKK---FSTKSDVWSFGILLWEIYSFGR-VP---------------YPRI-PLKDVVPRV----EKGYK----MDAPDGCP------PAVYE-VMKNCWHLDAAMRPSFLQLREQL----
----LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL---R-P--DAT-KNA-RNDFL-K-----EVKIMSRL--KDPNIIRLLGVCV--Q-DDP--LCMITDYMENGDLNQFLS---AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATL--NFVHRDLATRNCLVGE-----NFTI---KIADFGMSRNL-----Y----A--GDYY--------------RVQGRAVLPIRWMAWECIL----MGK---FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL-TDEQVIENAGEFFRDQGRQ-VYLSRPPACP------QGLYE-LMLRCWSRESEQRPPFSQLHRFL----
---F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKIPVAIKEL---R-E--ATS-PKA-NKEIL-D-----EAYVMASV--DNPHVCRLLGICL----TST--VQLITQLMPFGCLLDYVR---EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR--RLVHRDLAARNVLVKT-----PQHV---KITDFGLAKLL-----G----A--EEKE--------------YHAEGGKVPIKWMALESIL----HRI---YTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI-PASEISSIL----EKGER----LPQPPICT------IDVYM-IMVKCWMIDADSRPKFRELI----IEF
----IHIEKIIGSGDSGEVCYGRLR-------------VPGQRDVPVAIKAL---K-A--GYT-ERQ-RRDFL-S-----EASIMGQF--DHPNIIRLEGVVT--R-GRL--AMIVTEYMENGSLDTFLR---TH--------------------------------------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSDL--GYVHRDLAARNVLVDS-----NLVC---KVSDFGLSRVL-----E----D--DPDA-------------AYTTTGGKIPIRWTAPEAIA----FRT---FSSASDVWSFGVVMWEVLAYGE-RP---------------YWNM-TNRDVISSV----EEGYR----LPAPMGCP------HALHQ-LMLDCWHKDRAQRPRFSQIVSVL----
---V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREIYVAIKTL---K-A--GYS-EKQ-RRDFL-S-----EASIMGQF--DHPNIIRLEGVVT--K-SRP--VMIITEFMENGALDSFLR---QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEM--NYVHRDLAARNILVNS-----NLVC---KVSDFGLSRYLQ--DDT----S--DPTY--------------TSSLGGKIPVRWTAPEAIA----YRK---FTSASDVWSYGIVMWEVMSFGE-RP---------------YWDM-SNQDVINAI----EQDYR----LPPPMDCP------AALHQ-LMLDCWQKDRNSRPRFAEIVNTL----
---V-KIEQVIGAGEFGEVCSGHLK-------------LPGKREIFVAIKTL---K-S--GYT-EKQ-RRDFL-S-----EASIMGQF--DHPNVIHLEGVVT--K-STP--VMIITEFMENGSLDSFLR---QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADM--NYVHRDLAARNILVNS-----NLVC---KVSDFGLSRFLE--DDT----S--DPTY--------------TSALGGKIPIRWTAPEAIQ----YRK---FTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM-TNQDVINAI----EQDYR----LPPPMDCP------SALHQ-LMLDCWQKDRNHRPKFGQIVNTL----
---V-KIEEVIGAGEFGEVCRGRLK-------------APGKKESCVAIKTL---K-G--GYT-ERQ-RREFL-S-----EASIMGQF--EHPNIIRLEGVVT--N-SMP--VMILTEFMENGALDSFLR---LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEM--SYVHRDLAARNILVNS-----NLVC---KVSDFGLSRFLE--ENS----S--DPTY--------------TSSLGGKIPIRWTAPEAIA----FRK---FTSASDAWSYGIVMWEVMSFGE-RP---------------YWDM-SNQDVINAI----EQDYR----LPPPPDCP------TSLHQ-LMLDCWQKDRNARPRFPQVVSAL----
----IKIEEVIGTGSFGEVRQGRLQ-------------PRGRREQTVAIQAL---W-A--GGA-ESL-QMTFL-G-----RAAVLGQF--QHPNILRLEGVVT--K-SRP--LMVLTEFMELGPLDSFLR---QR--------------------------------------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSF--AFVHRSLSAHSVLVNS-----HLVC---KVARLGHSPQG------------------------------------PSCLLRWAAPEVIA----HGK---HTTSSDVWSFGILMWEVMSYGE-RP---------------YWDM-SEQEVLNAI----EQEFR----LPPPPGCP------PGLHL-LMLDTWQKDRARRPHFDQLVA---AF-
---L-KRVKVLGSGAFGTVYKGIWVP------------EGETVKIPVAIKIL---N-E--TTG-PKA-NVEFM-D-----EALIMASM--DHPHLVRLLGVCL----SPT--IQLVTQLMPHGCLLEYVH---EH--------------------------------------------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEER--RLVHRDLAARNVLVKS-----PNHV---KITDFGLARLL-----E----G--DEKE--------------YNADGGKMPIKWMALECIH----YRK---FTHQSDVWSYGVTIWELMTFGG-KP---------------YDGI-PTREIPDLL----EKGER----LPQPPICT------IDVYM-VMVKCWMIDADSRPKFKELAAE--F--
--VI--LGELLGKGNFGEVYKGTLK-----------------DKTSVAVKTC---K-E--DLP-QEL-KIKFL-Q-----EAKILKQY--DHPNIVKLIGVCT--Q-RQP--VYIIMELVSGGDFLTFLR---RK--------------------------------------------------------------------------------------------------KDELKLKQLVKFSLDAAAGMLYLESK--NCIHRDLAARNCLVGE-----NNVL---KISDFGMSRQE----------D--GGVY--------------SSSGLKQIPIKWTAPEALN----YGR---YSSESDVWSFGILLWETFSLGV-CP---------------YPGM-TNQQAREQV----ERGYR----MSAPQHCP------EDISK-IMMKCWDYKPENRPKFSELQKEL----
---L-VLGEQIGRGNFGEVFSGRLR----------------ADNTLVAVKSC---R-E--TLP-PDL-KAKFL-Q-----EARILKQY--SHPNIVRLIGVCT--Q-KQP--IYIVMELVQGGDFLTFLR---TE--------------------------------------------------------------------------------------------------GARLRVKTLLQMVGDAAAGMEYLESK--CCIHRDLAARNCLVTE-----KNVL---KISDFGMSREE-----A----D--GVYA--------------ASGGLRQVPVKWTAPEALN----YGR---YSSESDVWSFGILLWETFSLGA-SP---------------YPNL-SNQQTREFV----EKGGR----LPCPELCP------DAVFR-LMEQCWAYEPGQRPSFSTIYQEL----
---L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKML---K-S--DAT-EKD-LSDLI-S-----EMEMMKMIG-KHKNIINLLGACT--Q-DGP--LYVIVEYASKGNLREYLQ---ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--KCIHRDLAARNVLVTE-----DNVM---KIADFGLARDI-----H----H--IDYY--------------KKTTNGRLPVKWMAPEALF----DRI---YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV-PVEELFKLL----KEGHR----MDKPSNCT------NELYM-MMRDCWHAVPSQRPTFKQLVEDL----
----LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAVKML---K-D--DAT-EKD-LSDLV-S-----EMEMMKMIG-KHKNIINLLGACT--Q-DGP--LYVIVEYASKGNLREYLR---ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ--KCIHRDLAARNVLVTE-----NNVM---KIADFGLARDI-----N----N--IDYY--------------KKTTNGRLPVKWMAPEALF----DRV---YTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI-PVEELFKLL----KEGHR----MDKPANCT------NELYM-MMRDCWHAVPSQRPTFKQLVEDL----
----LTLGKPLGEGCFGQVVMAEAIGI---------DKDRAAKPVTVAVKML---K-D--DAT-DKD-LSDLV-S-----EMEMMKMIG-KHKNIINLLGACT--Q-GGP--LYVLVEYAAKGNLREFLR---ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQ--KCIHRDLAARNVLVTE-----DNVM---KIADFGLARDV-----H----N--LDYY--------------KKTTNGRLPVKWMAPEALF----DRV---YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI-PVEELFKLL----KEGHR----MDKPANCT------HDLYM-IMRECWHAAPSQRPTFKQLVEDL----
---L-VLGKPLGEGCFGQVVRAEAFGM---------DPARPDQASTVAVKML---K-D--NAS-DKD-LADLV-S-----EMEVMKLIG-RHKNIINLLGVCT--Q-EGP--LYVIVECAAKGNLREFLR---ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESR--KCIHRDLAARNVLVTE-----DNVM---KIADFGLARGV-----H----H--IDYY--------------KKTSNGRLPVKWMAPEALF----DRV---YTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI-PVEELFSLL----REGHR----MDRPPHCP------PELYG-LMRECWHAAPSQRPTFKQLVEAL----
----ITLERRLGTGCFGDVWLGTWN-----------------GSTKVAVKTL---K-P--GTM-SP---KAFL-E-----EAQVMKLL--RHDKLVQLYAVVS----EEP--IYIVTEFMCHGSLLDFLK---NP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERM--NYIHRDLRAANILVGE-----RLAC---KIADFGLARLI----------K--DDEY--------------NPCQGSKFPIKWTAPEAAL----FGR---FTIKSDVWSFGILLTELITKGR-IP---------------YPGM-NKREVLEQV----EQGYH----MPCPPGCP------ASLYE-AMEQTWRLDPEERPTFEYLQSFL----
----LQLIKRLGNGQFGEVWMGTWN-----------------GNTKVAIKTL---K-P--GTM-SP---ESFL-E-----EAQIMKKL--KHDKLVQLYAVVS----EEP--IYIVTEYMNKGSLLDFLK---DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERM--NYIHRDLRSANILVGN-----GLIC---KIADFGLARLI----------E--DNEY--------------TARQGAKFPIKWTAPEAAL----YGR---FTIKSDVWSFGILLTELVTKGR-VP---------------YPGM-NNREVLEQV----ERGYR----MPCPQDCP------ISLHE-LMIHCWKKDPEERPTFEYLQSFL----
----LKLEKKLGAGQFGEVWMATYN-----------------KHTKVAVKTM---K-P--GSM-SV---EAFL-A-----EANVMKTL--QHDKLVKLHAVVT----KEP--IYIITEFMAKGSLLDFLK---SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR--NYIHRDLRAANILVSA-----SLVC---KIADFGLARVI----------E--DNEY--------------TAREGAKFPIKWTAPEAIN----FGS---FTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM-SNPEVIRAL----ERGYR----MPRPENCP------EELYN-IMMRCWKNRPEERPTFEYIQSV--L--
----ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAVKTV---N-E--SAS-LRE-RIEFL-N-----EASVMKGF--TCHHVVRLLGVVS--K-GQP--TLVVMELMAHGDLKSYLR---SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK--KFVHRDLAARNCMVAH-----DFTV---KIGDFGMTRDI-----Y----E--TDYY--------------RKGGKGLLPVRWMAPESLK----DGV---FTTSSDMWSFGVVLWEITSLAE-QP---------------YQGL-SNEQVLKFV----MDGGY----LDQPDNCP------ERVTD-LMRMCWQFNPKMRPTFLEIVNLL----
----LTFVQEIGSGQFGLVHLGYWL-----------------NKDKVAIKTI---R-E--GAM-SE---EDFI-E-----EAEVMMKL--SHPKLVQLYGVCL--E-QAP--ICLVFEFMEHGCLSDYLR---TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEA--CVIHRDLAARNCLVGE-----NQVI---KVSDFGMTRFV----------L--DDQY--------------TSSTGTKFPVKWASPEVFS----FSR---YSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR-SNSEVVEDI----STGFR----LYKPRLAS------THVYQ-IMNHCWKERPEDRPAFSRLLRQL----
---L-KRIRDLGEGHFGKVELCRYDP------------EGDNTGEQVAVKSL---K-P--ESG-GNH-IADLK-K-----EIEILRNL--YHENIVKYKGICT-ED--GGNGIKLIMEFLPSGSLKEYLP---KN--------------------------------------------------------------------------------------------------KNKINLKQQLKYAVQICKGMDYLGSR--QYVHRDLAARNVLVES-----EHQV---KIGDFGLTKAI----ET----D--KEYY--------------TVKDDRDSPVFWYAPECLM----QSK---FYIASDVWSFGVTLHELLTYCD-SDSSPMALF-LKMIGPTHGQM-TVTRLVNTL----KEGKR----LPCPPNCP------DEVYQ-LMRKCWEFQPSNRTSFQNLIE---GF-
----LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAVKKL---Q-H--STE--EH-LRDFE-R-----EIEILKSL--QHDNIVKYKGVCYSAG-RRN--LKLIMEYLPYGSLRDYLQ---KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK--RYIHRDLATRNILVEN-----ENRV---KIGDFGLTKVL----PQ----D--KEYY--------------KVKEPGESPIFWYAPESLT----ESK---FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM-IVFHLIELL----KNNGR----LPRPDGCP------DEIYM-IMTECWNNNVNQRPSFRDLA----LRV
---L-KYISQLGKGNFGSVELCRYDP------------LGDNTGALVAVKQL---Q-H--SGP-DQ--QRDFQ-R-----EIQILKAL--HSDFIVKYRGVSYGPG-RQS--LRLVMEYLPSGCLRDFLQ---RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSR--RCVHRDLAARNILVES-----EAHV---KIADFGLAKLL----PL----D--KDYY--------------VVREPGQSPIFWYAPESLS----DNI---FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDVPALCRLLELL----EEGQR----LPAPPACP------AEVHE-LMKLCWAPSPQDRPSFSALGP---QL-
----LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAVKML---K-P--SAH-LTE-REALM-S-----ELKVLSYLG-NHMNIVNLLGACT--I-GGP--TLVITEYCCYGDLLNFLR---RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK--NCIHRDLAARNILLTH-----GRIT---KICDFGLARDI-----K----N--DSNY--------------VVKGNARLPVKWMAPESIF----NCV---YTFESDVWSYGIFLWELFSLGS-SP---------------YPGMPVDSKFYKMI----KEGFR----MLSPEHAP------AEMYD-IMKTCWDADPLKRPTFKQIVQL--I--
----LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSL---K-Q--GSM-SP---DAFL-A-----EANLMKQL--QHQRLVRLYAVVT----QEP--IYIITEYMENGSLVDFLK---TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER--NYIHRDLRAANILVSD-----TLSC---KIADFGLARLI----------E--DNEY--------------TAREGAKFPIKWTAPEAIN----YGT---FTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM-TNPEVIQNL----ERGYR----MVRPDNCP------EELYQ-LMRLCWKERPEDRPTFDYLRSV--L--
---V-TLLRALGHGAFGEVYEGLVIG-----------LPGDSSPLQVAIKTL---P-E--LCS-PQD-ELDFL-M-----EALIISKF--RHQNIVRCVGLSL--R-ATP--RLILLELMSGGDMKSFLR---HSRP--------------------------------------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEEN--HFIHRDIAARNCLLSCA--GPSRVA---KIGDFGMARDI-----Y----R--ASYY--------------RRGDRALLPVKWMPPEAFL----EGI---FTSKTDSWSFGVLLWEIFSLGY-MP---------------YPGR-TNQEVLDFV----VGGGR----MDPPRGCP------GPVYR-IMTQCWQHEPELRPSFASILERL----
----IKLVKRLGAGQFGEVWMGYYN-----------------NSTKVAVKTL---K-P--GTM-SV---QAFL-E-----EANLMKTL--QHDKLVRLYAVVT--R-EEP--IYIITEYMAKGSLLDFLK---SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERK--NYIHRDLRAANVLVSE-----SLMC---KIADFGLARVI----------E--DNEY--------------TAREGAKFPIKWTAPEAIN----FGC---FTIKSDVWSFGILLYEIVTYGK-IP---------------YPGR-TNADVMTAL----SQGYR----MPRVENCP------DELYD-IMKMCWKEKAEERPTFDYLQSV--L--
----YRLLKTIGKGNFAKVKLARHI----------------LTGKEVAVKII---DKT--QLNSSS---LQKLFR-----EVRIMKVL--NHPNIVKLFEVIE--T-EKT--LYLVMEYASGGEVFDYLV--AHG----------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVQYCHQK--FIVHRDLKAENLLLDA-----DMNI---KIADFGFSNE-----------FTFGNKL--------------DT---FCGSPPYAAPELFQ---GKKY---DGPEVDVWSLGVILYTLVS-GS-LP---------------FDGQ----NLKELR----ERVLR----GKYRIPFYMS----TDCEN-LLKKFLILNPSKRGTLEQIMKDRWM--
----YRLLRTIGKGNFAKVKLARHI----------------LTGREVAIKII---DKT--QLNPSS---LQKLFR-----EVRIMKGL--NHPNIVKLFEVIE--T-EKT--LYLVMEYASAGEVFDYLV--SHG----------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVHYCHQK--NIVHRDLKAENLLLDA-----EANI---KIADFGFSNE-----------FTLGSKL--------------DT---FCGSPPYAAPELFQ---GKKY---DGPEVDIWSLGVILYTLVS-GS-LP---------------FDGH----NLKELR----ERVLR----GKYRVPFYMS----TDCES-ILRRFLVLNPAKRCTLEQIMKDKWI--
----YRIRGEIGSGNFSQVKLGIHS----------------LTKEKVAIKIL---DKT--KLDQKT---QRLLSR-----EISSMEKL--HHPNIIRLYEVVE--T-LSK--LHLVMEYAGGGELFGKIS--TEG----------------------------------------------------------------------------------------------------KLSEPESKLIFSQIVSAVKHMHEN--QIIHRDLKAENVFYTS-----NTCV---KVGDFGFSTV-----------SKKGEML--------------NT---FCGSPPYAAPELFR---DEHY---IGIYVDIWALGVLLYFMVT-GT-MP---------------FRAE----TVAKLK----KSILE----GTYSVPPHV----SEPCHR-LIRGVLQQIPTERYGIDCIMNDEWM--
---I-EYVRDIGEGAFGRVFQARAPG-----------LLPYEPFTMVAVKML---K-E--EAS-ADM-QADFQ-R-----EAALMAEF--DNPNIVKLLGVCA--V-GKP--MCLLFEYMAYGDLNEFLR---SMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSER--KFVHRDLATRNCLVGE-----NMVV---KIADFGLSRNI-----Y----S--ADYY--------------KANENDAIPIRWMPPESIF----YNR---YTTESDVWAYGVVLWEIFSYGL-QP---------------YYGM-AHEEVIYYV----RDGNI----LSCPENCP------VELYN-LMRLCWSKLPADRPSFTSIHRIL----
---I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKILVAVKTL---K-D--ASD-NA--RKDFH-R-----EAELLTNL--QHEHIVKFYGVCV--E-GDP--LIMVFEYMKHGDLNKFLR---AHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQ--HFVHRDLATRNCLVGE-----NLLV---KIGDFGMSRDV-----Y----S--TDYY--------------RVGGHTMLPIRWMPPESIM----YRK---FTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL-SNNEVIECI----TQGRV----LQRPRTCP------QEVYE-LMLGCWQREPHMRKNIKGIHTL--L--
---I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKMLVAVKAL---K-D--PTL-AA--RKDFQ-R-----EAELLTNL--QHEHIVKFYGVCG--D-GDP--LIMVFEYMKHGDLNKFLR---AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQ--HFVHRDLATRNCLVGA-----NLLV---KIGDFGMSRDV-----Y----S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM----YRK---FTTESDVWSFGVILWEIFTYGK-QP---------------WFQL-SNTEVIECI----TQGRV----LERPRVCP------KEVYD-VMLGCWQREPQQRLNIKEIYKIL----
----YELQETLGKGTYGKVKRATER----------------FSGRVVAIKSI---RKD--KIKDEQ---DMVHIR----REIEIMSSL--NHPHIISIYEVFE--N-KDK--IVIIMEYASKGELYDYIS--ERR----------------------------------------------------------------------------------------------------RLSERETRHFFRQIVSAVHYCHKN--GVVHRDLKLENILLDD-----NCNI---KIADFGLSNL-----------YQKDKFL--------------QT---FCGSPLYASPEIVN---GRPY---RGPEVDSWALGVLLYTLVY-GT-MP---------------FDGF----DHKNLI----RQISS----GEYREPTQP-----SDARG-LIRWMLMVNPDRRATIEDIANHWW-V-
----YEFLETLGKGTYGKVKKARES----------------SGR-LVAIKSI---RKD--KIKDEQ---DLMHIR----REIEIMSSL--NHPHIIAIHEVFE--N-SSK--IVIVMEYASRGDLYDYIS--ERQ----------------------------------------------------------------------------------------------------QLSEREARHFFRQIVSAVHYCHQN--RVVHRDLKLENILLDA-----NGNI---KIADFGLSNL-----------YHQGKFL--------------QT---FCGSPLYASPEIVN---GKPY---TGPEVDSWSLGVLLYILVH-GT-MP---------------FDGH----DHKILV----KQISN----GAYREPPK-----PSDACG-LIRWLLMVNPTRRATLEDVASHWW-V-
---L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAVKML---K-P--TAR-SSE-KQALM-S-----ELKIMTHLG-PHLNIVNLLGACT--K-SGP--IYIITEYCFYGDLVNYLH---KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASK--NCVHRDLAARNVLLAQ-----GKIV---KICDFGLARDI-----M----H--DSNY--------------VSKGSTFLPVKWMAPESIF----DNL---YTTLSDVWSYGILLWEIFSLGG-TP---------------YPGMMVDSTFYNKI----KSGYR----MAKPDHAT------SEVYE-IMVKCWNSEPEKRPSFYHLSE---IV-
---L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAVKML---K-S--TAR-SSE-KQALM-S-----ELKIMSHLG-PHLNVVNLLGACT--K-GGP--IYIITEYCRYGDLVDYLH---RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASK--NCVHRDLAARNVLICE-----GKLV---KICDFGLARDI-----M----R--DSNY--------------ISKGSTFLPLKWMAPESIF----NSL---YTTLSDVWSFGILLWEIFTLGG-TP---------------YPELPMNEQFYNAI----KRGYR----MAQPAHAS------DEIYE-IMQKCWEEKFEIRPPFSQLVL---LL-
----IELGRCIGEGQFGDVHQGIYM-------------SPENPALAVAIKTC---K-N--CTS-DSV-REKFL-Q-----EALTMRQF--DHPHIVKLIGVIT----ENP--VWIIMELCTLGELRSFLQ---VR--------------------------------------------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLESK--RFVHRDIAARNVLVSS-----NDCV---KLGDFGLSRYM----------E--DSTY--------------YKASKGKLPIKWMAPESIN----FRR---FTSASDVWMFGVCMWEILMHGV-KP---------------FQGV-KNNDVIGRI----ENGER----LPMPPNCP------PTLYS-LMTKCWAYDPSRRPRFTELKAQL----
---F-TLCRKLGSGYFGEVFEGLWK-----------------DRVQVAIKVI---S-R--DNL-LH--QQMLQ-S-----EIQAMKKL--RHKHILALYAVVS--V-GDP--VYIITELMAKGSLLELLR---DS-------------------------------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQ--NYIHRDLAARNILVGE-----NTLC---KVGDFGLARLI-------------KEDV--------------YLSHDHNIPYKWTAPEALS----RGH---YSTKSDVWSFGILLHEMFSRGQ-VP---------------YPGM-SNHEAFLRV----DAGYR----MPCPLECP------PSVHK-LMLTCWCRDPEQRPCFKALRERL----
---L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYTTVAVKML---K-E--NAS-PSE-LRDLL-S-----EFNVLKQV--NHPHVIKLYGACS--Q-DGP--LLLIVEYAKYGSLRGFLR---ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM--KLVHRDLAARNILVAE-----GRKM---KISDFGLSRDV-----Y----E--EDSY--------------VKRSQGRIPVKWMAIESLF----DHI---YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI-PPERLFNLL----KTGHR----MERPDNCS------EEMYR-LMLQCWKQEPDKRPVFADISKDL----
--LT--LRLLLGSGAFGEVYEGTAVDI----------LGVGSGEIKVAVKTL---K-K--GST-DQE-KIEFL-K-----EAHLMSKF--NHPNILKQLGVCL--L-NEP--QYIILELMEGGDLLTYLR---KARM--------------------------------------------------------------------------------------------ATFYGPLLTLVDLVDLCVDISKGCVYLERM--HFIHRDLAARNCLVSVKDYTSPRIV---KIGDFGLARDI-----Y----K--NDYY--------------RKRGEGLLPVRWMAPESLM----DGI---FTTQSDVWSFGILIWEILTLGH-QP---------------YPAH-SNLDVLNYV----QTGGR----LEPPRNCP------DDLWN-LMTQCWAQEPDQRPTFHRIQDQL----
----YDIEGTLGKGNFAVVKLGRHR----------------ITKTEVAIKII---DKS--QLDAVN---LEKIYR-----EVQIMKML--DHPHIIKLYQVME--T-KSM--LYLVTEYAKNGEIFDYLA--NHG----------------------------------------------------------------------------------------------------RLNESEARRKFWQILSAVDYCHGR--KIVHRDLKAENLLLDN-----NMNI---KIADFGFGNF-----------FKSGELL--------------AT---WCGSPPYAAPEVFE---GQQY---EGPQLDIWSMGVVLYVLVC-GA-LP---------------FDGP----TLPILR----QRVLE----GRFRIPYFMS----EDCEH-LIRRMLVLDPSKRLTIAQIKEHKWM--
---L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAIKTL---K-P--GTM-SP---EAFL-Q-----EAQVMKKL--RHEKLVQLYAVVS----EEP--IYIVTEYMSKGSLLDFLK---GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM--NYVHRDLRAANILVGE-----NLVC---KVADFGLARLI----------E--DNEY--------------TARQGAKFPIKWTAPEAAL----YGR---FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM-VNREVLDQV----ERGYR----MPCPPECP------ESLHD-LMCQCWRKEPEERPTFEYLQAF--L--
--FA--LGRKLGEGYFGEVWEGLWL-----------------GSLPVAIKVI---K-S--ANM-K---LTDLA-K-----EIQTLKGL--RHERLIRLHAVCS--G-GEP--VYIVTELMRKGNLQAFLG---TP-------------------------------------------------------------------------------------------------EGRALRLPPLLGFACQVAEGMSYLEEQ--RVVHRDLAARNVLVDD-----GLAC---KVADFGLARLL----------K--DDIY--------------SPSSSSKIPVKWTAPEAAN----YRV---FSQKSDVWSFGVLLHEVFTYGQ-CP---------------YEGM-TNHETLQQI----MRGYR----LPRPAACP------AEVYV-LMLECWRSSPEERPSFATLREKL----
-LCP---GRELGRGKFAVVRKCIKK----------------DSGKEFAAKFM---RKR--RKGQDC---RMEIIH-----EIAVLELA-QDNPWVINLHEVYE--T-ASE--MILVLEYAAGGEIFDQCVADREE----------------------------------------------------------------------------------------------------AFKEKDVQRLMRQILEGVHFLHTR--DVVHLDLKPQNILLTS-----ESPLGDIKIVDFGLSRI-----------LKNSEEL--------------RE---IMGTPEYVAPEILS----YDP---ISMATDMWSIGVLTYVMLT-GI-SP---------------FLGN----DKQETF----LNISQ----MNLSYSEEEFDVLSESAVD-FIRTLLVKKPEDRATAEECLKHPWL--
---F-TKLDRIGKGSFGEVYKGIDN----------------HTKEVVAIKII---DLE--EAEDEI---EDIQ-Q-----EITVLSQC--DSPYITRYFGSYL--K-STK--LWIIMEYLGGGSALDLLK---PG----------------------------------------------------------------------------------------------------PLEETYIATILREILKGLDYLHSE--RKIHRDIKAANVLLSE-----QGDV---KLADFGVAGQL----------TDTQIKR--------------NT---FVGTPFWMAPEVIK----QSA---YDFKADIWSLGITAIELAK-GE-PP---------------NSDL-HPMRVLFLI----PKNSP----PTLEGQHS------KPFKE-FVEACLNKDPRFRPTAKELLKHKFI--
-TLE---DKELGSGNFGTVKKGYYQ--------------MKKVVKTVAVKIL---K-N--EAN-DPALKDELL-A-----EANVMQQL--DNPYIVRMIGICE----AES--WMLVMEMAELGPLNKYLQ---QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEES--NFVHRDLAARNVLLVT-----QHYA---KISDFGLSKAL-----R----A--DENY-------------YKAQTHGKWPVKWYAPECIN----YYK---FSSKSDVWSFGVLMWEAFSYGQ-KP---------------YRGM-KGSEVTAML----EKGER----MGCPAGCP------REMYD-LMNLCWTYDVENRPGFAAVE----LRL
----LTFMRELGSGLFGVVRLGKWR-----------------AQYKVAIKAI---R-E--GAM-CE---EDFI-E-----EAKVMMKL--THPKLVQLYGVCT--Q-QKP--IYIVTEFMERGCLLNFLR---QR--------------------------------------------------------------------------------------------------QGHFSRDVLLSMCQDVCEGMEYLERN--SFIHRDLAARNCLVSE-----AGVV---KVSDFGMARYV----------L--DDQY--------------TSSSGAKFPVKWCPPEVFN----YSR---FSSKSDVWSFGVLMWEVFTEGR-MP---------------FEKY-TNYEVVTMV----TRGHR----LYQPKLAS------NYVYE-VMLRCWQEKPEGRPSFEDLLRT--I--
--YL--LLHLLGRGGFSEVYKAFDL----------------TEQRYVAVKIH---QLN--KNWRDE---KKENYHKHACREYRIHKEL--DHPRIVKLYDYFS--LDTDS--FCTVLEYCEGNDLDFYLK--QHK----------------------------------------------------------------------------------------------------LMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVN-----GTACGEIKITDFGLSKIMDDD---SYNSVDGMELT--------------SQ---GAGTYWYLPPECFVVGKEPPK---ISNKVDVWSVGVIFYQCLY-GR-KP---------------FGHN--QSQQDILQ----ENTIL----KATEVQFPPKPVVTPEAKA-FIRRCLAYRKEDRIDVQQLACDPYL--
-VCR---GELLGSGCFGVVHRGLWT-------------LPSGKSVPVAVKSLRVGP-E--GPM-GTE-LGDFL-R-----EVSVMMNL--EHPHVLRLHGLVL----GQP--LQMVMELAPLGSLHARLT---AP------------------------------------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGAR--GLVHRDLATRNLLLAS-----PRTI---KVADFGLVRPL----GG----A--RGRY--------------VMGGPRPIPYAWCAPESLR----HGA---FSSASDVWMFGVTLWEMFSGGE-EP---------------WAGV-PPYLILQRL----EDRAR----LPRPPLCS------RALYS-LALRCWAPHPADRPSFSHLE----GLL
---L-RLLEKLGDGSFGVVRRGEWD-------------APSGKTVSVAVKCL---K-PDVLSQ-PEA-MDDFI-R-----EVNAMHSL--DHRNLIRLYGVVL----TPP--MKMVTELAPLGSLLDRLR---KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK--RFIHRDLAARNLLLAT-----RDLV---KIGDFGLMRAL----PQ----N--DDHY--------------VMQEHRKVPFAWCAPESLK----TRT---FSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL-NGSQILHKI---DKEGER----LPRPEDCP------QDIYN-VMVQCWAHKPEDRPTFVALRDF--L--
---L-AFIKEIGSGQFGVVHLGEWR-----------------SHIQVAIKAI---N-E--GSM-SE---EDFI-E-----EAKVMMKL--SHSKLVQLYGVCI--Q-RKP--LYIVTEFMENGCLLNYLR---EN--------------------------------------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLERN--GYIHRDLAARNCLVSS-----TCIV---KISDFGMTRYV----------L--DDEY--------------VSSFGAKFPIKWSPPEVFL----FNK---YSSKSDVWSFGVLMWEVFTEGK-MP---------------FENK-SNLQVVEAI----SEGFR----LYRPHLAP------MSIYE-VMYSCWHEKPEGRPTFAELLR---AV-
---L-KKIRDLGEGHFGKVSLYCYDP------------TNDGTGEMVAVKAL---K-A--DCG-PQH-RSGWK-Q-----EIDILRTL--YHEHIIKYKGCCEDQG-EKS--LQLVMEYVPLGSLRDYLP---RH----------------------------------------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHAQ--HYIHRDLAARNVLLDN-----DRLV---KIGDFGLAKAV----PE----G--HEYY--------------RVREDGDSPVFWYAPECLK----EYK---FYYASDVWSFGVTLYELLTHCD-SSQSPPTKF-LELIGIAQGQM-TVLRLTELL----ERGER----LPRPDKCP------CEVYH-LMKNCWETEASFRPTFENLIP---IL-
---L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAIKTL---K-P--GTM-MP---EAFL-Q-----EAQIMKKL--RHDKLVPLYAVVS----EEP--IYIVTEFMSKGSLLDFLK---EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERM--NYIHRDLRAANILVGE-----NLVC---KIADFGLARLI----------E--DNEY--------------TARQGAKFPIKWTAPEAAL----YGR---FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM-VNREVLEQV----ERGYR----MPCPQGCP------ESLHE-LMNLCWKKDPDERPTFEYIQSFL----
LIAD----IELGCGNFGSVRQGVYR--------------MRKKQIDVAIKVL---K-Q--GTE-KAD-TEEMM-R-----EAQIMHQL--DNPYIVRLIGVCQ----AEA--LMLVMEMAGGGPLHKFLV---GK--------------------------------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEK--NFVHRDLAARNVLLVN-----RHYA---KISDFGLSKAL----GA----D--DSYY--------------TARSAGKWPLKWYAPECIN----FRK---FSSRSDVWSYGVTMWEALSYGQ-KP---------------YKKM-KGPEVMAFI----EQGKR----MECPPECP------PELYA-LMSDCWIYKWEDRPDFLTVEQR--M--
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