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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC GRK7 203
TK ABL1 261
TK ABL2 288
AGC AKT1 150
Other AURKA 133
Other AURKB 77
Other AURKC 43
TKL BRAF 456
CAMK BRSK1 50
CAMK BRSK2 19
TK BTK 402
CAMK CAMK1G 23
CAMK CAMK2A 13
CAMK CAMK2B 14
CAMK CAMK2D 14
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK7 2.7.11.23
CMGC CDKL2 4
CAMK CHEK1 9
CAMK CHEK2 220
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
CMGC DYRK1A 150
CMGC DYRK1B 111
CMGC DYRK2 222
TK EGFR 712
Other EIF2AK2 267
Other EIF2AK4 590
TK EPHA3 621
TK EPHA5 675
TK EPHB1 619
TK FGFR2 481
Other GAK 40
AGC GRK1 190
AGC GRK4 187
AGC GRK6 186
CMGC GSK3A 119
CMGC GSK3B 56
CMGC HIPK1 190
CMGC HIPK2 199
CMGC HIPK3 197
CMGC HIPK4 -1
CAMK HUNK 61
CMGC ICK 4
TKL IRAK4 186
TK JAK2 849
TK JAK3 822
TKL LIMK2 331
TK LYN 247
STE MAP3K15 649
STE MAP3K2 356
STE MAP3K3 362
STE MAP3K4 1342
CMGC MAPK10 64
CMGC MAPK14 24
CMGC MAPK7 55
CMGC MAPK8 26
CMGC MAPK9 26
CAMK MAPKAPK2 64
CAMK MARK2 53
CAMK MARK4 59
TK MATK 235
CAMK MELK 11
CAMK MGC42105 74
Other NEK2 8
CAMK NUAK1 55
CAMK NUAK2 97
STE OXSR1 17
STE PAK2 249
STE PAK3 268
STE PAK4 321
STE PAK6 407
STE PAK7 449
CMGC PCTK1 165
CMGC PCTK2 192
CMGC PCTK3 172
AGC PDPK1 82
CMGC PFTK1 117
CAMK PHKG1 20
CAMK PHKG2 24
CAMK PIM2 132
CAMK PIM3 40
AGC PKN2 657
Other PLK1 53
Other PLK2 82
Other PLK4 12
CAMK PRKAA1 18
CAMK PRKAA2 16
AGC PRKCB 342
AGC PRKCD 349
AGC PRKCH 355
AGC PRKCQ 380
AGC PRKCZ 252
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
AGC PRKG1 375
CMGC PRPF4B 687
TK RET 724
TKL RIPK1 17
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA6 73
AGC RPS6KB1 91
Other SBK1 53
CAMK SIK1 27
CAMK SIK2 20
STE SLK 34
CAMK SNRK 16
CAMK STK11 49
CAMK STK17A 61
CAMK STK17B 33
STE STK24 24
CAMK STK33 116
STE STK39 63
Other TLK1 477
Other TLK2 440
CAMK TSSK1B 12
Other TTK 525
TK TXK 271
Other ULK1 16
Other ULK2 9
Other ULK3 14
STE YSK4 1162
-------------------------------F-TEFRVLGKGGFGEV---CAVQV---K-------N-TGK---MYAC-KKL-DKK-R-LKK---KG--G-E-KMAL------LEKEILEKV--S------SPF-----IVSLAYAFE--S-----------------------------KTHLC--LVMSL-MNGG--DLKFHIYN------VGTR-------------------------GL---DMSRVIFYSAQIACGMLHLHE--L-----GIVYRDMKPENVLLD---DLGNC---------RLSDLGLAVE------------------------MKGGKPI---------TQ---RAGTNGYMAPEI-LM----------EKVS---YSYPVDWFAMGCSIYEMVA-GR-TP---------------FK-DY---KEKVSK-EDLKQRTLQ----DE---VKFQHDNF---T-----------------------------------------------------------------------EEAKDICRLFLAKKPEQRLG------SR-E-------KSDDPR--------
--------------------------------ITMKHKLGGGQYGEV---YEGVW---K-------K-YSL---TVAV-KTL-K-E-D-TM----EV--E-E-FL-K-------EAAVMKEI--K------HPN-----LVQLLGVCT--R-----------------------------EPPFY--IITEF-MTYG--NLLDYLR---------EC----------------------NRQEV---NAVVLLYMATQISSAMEYLEK--K-----NFIHRDLAARNCLVG---ENHLV---------KVADFGLSRLM-----------------------T--GDTY---------TAHAGAKFPIKWTAPES-LA-----------YNK---FSIKSDVWAFGVLLWEIATYGM-SP---------------YP-GI----DLSQV-YELLEKDYR----ME---RPEGCP-----------------------------------------------------------------------------EKVYELMRACWQWNPSDRPS------FA-EIHQA--F--------------
--------------------------------ITMKHKLGGGQYGEV---YVGVW---K-------K-YSL---TVAV-KTL-K-E-D-TM----EV--E-E-FL-K-------EAAVMKEI--K------HPN-----LVQLLGVCT--L-----------------------------EPPFY--IVTEY-MPYG--NLLDYLR---------EC----------------------NREEV---TAVVLLYMATQISSAMEYLEK--K-----NFIHRDLAARNCLVG---ENHVV---------KVADFGLSRLM-----------------------T--GDTY---------TAHAGAKFPIKWTAPES-LA-----------YNT---FSIKSDVWAFGVLLWEIATYGM-SP---------------YP-GI----DLSQV-YDLLEKGYR----ME---QPEGCP-----------------------------------------------------------------------------PKVYELMRACWKWSPADRPS------FA-ETHQA--F--------------
-------------------------------F-EYLKLLGKGTFGKV---ILVKE---K-------A-TGR---YYAM-KIL-KKE-V-IVA---KD--E-V-AHTL------TENRVLQNS--R------HPF-----LTALKYSFQ--T-----------------------------HDRLC--FVMEY-ANGG--ELFFHLS--------RER-------------------------VF---SEDRARFYGAEIVSALDYLHS-EK-----NVVYRDLKLENLMLD---KDGHI---------KITDFGLCKEG-----------------------IKDGATM---------KT---FCGTPEYLAPEV-LE-----------DND---YGRAVDWWGLGVVMYEMMC-GR-LP---------------FY-NQ-------DH-EKLFELILM----EE---IRFPRTLG---------------------------------------------------------------------------PEAKSLLSGLLKKDPKQRLGGG-SEDAK-EIMQHRFF--------------
--------------------------------FEIGRPLGKGKFGNV---YLARE---K-------Q-SKF---ILAL-KVL-FKA-QLEKA---GV--E-H-QLRR-------EVEIQSHL--R------HPN-----ILRLYGYFH--D-----------------------------ATRVY--LILEY-APLG--TVYRELQ--------KLS-------------------------KF---DEQRTATYITELANALSYCHS--K-----RVIHRDIKPENLLLG---SAGEL---------KIADFGWSV-------------------------HAPSSRR---------TT---LCGTLDYLPPEM-IE-----------GRM---HDEKVDLWSLGVLCYEFLV-GK-PP---------------FE-AN-------TY-QETYKRISR----VE---FTFPDFVT---------------------------------------------------------------------------EGARDLISRLLKHNPSQRPM------LR-EVLEHPWI--------------
--------------------------------FEIGRPLGKGKFGNV---YLARE---K-------K-SHF---IVAL-KVL-FKS-Q-IEK---EG--V-E-HQLR------REIEIQAHL--H------HPN-----ILRLYNYFY--D-----------------------------RRRIY--LILEY-APRG--ELYKELQ--------KSC-------------------------TF---DEQRTATIMEELADALMYCHG--K-----KVIHRDIKPENLLLG---LKGEL---------KIADFGWSV-------------------------HAPSLRR---------KT---MCGTLDYLPPEM-IE-----------GRM---HNEKVDLWCIGVLCYELLV-GN-PP---------------FE-SA-------SH-NETYRRIVK----VD---LKFPASVP---------------------------------------------------------------------------MGAQDLISKLLRHNPSERLP------LA-QVSAHPWV--------------
--------------------------------FEIGRPLGKGKFGNV---YLARL---K-------E-SHF---IVAL-KVL-FKS-Q-IEK---EG--L-E-HQLR------REIEIQAHL--Q------HPN-----ILRLYNYFH--D-----------------------------ARRVY--LILEY-APRG--ELYKELQ--------KSE-------------------------KL---DEQRTATIIEELADALTYCHD--K-----KVIHRDIKPENLLLG---FRGEV---------KIADFGWSV-------------------------HTPSLRR---------KT---MCGTLDYLPPEM-IE-----------GRT---YDEKVDLWCIGVLCYELLV-GY-PP---------------FE-SA-------SH-SETYRRILK----VD---VRFPLSMP---------------------------------------------------------------------------LGARDLISRLLRYQPLERLP------LA-QILKHPWV--------------
--------------------------------ITVGQRIGSGSFGTV---YKGKW---H-----------G---DVAV-KML-N-VTA-PT----PQQLQ-A-FK-N-------EVGVLRKT--R------HVN-----ILLFMGYST--------------------------------KPQLA--IVTQW-CEGS--SLYHHLH---------II-----------------------ETKF---EMIKLIDIARQTAQGMDYLHA--K-----SIIHRDLKSNNIFLH---EDLTV---------KIGDFGLATVK-------------S---------R--WSGS---------HQFEQLSGSILWMAPEV-IR-----------MQDKNPYSFQSDVYAFGIVLYELMT-GQ-LP---------------YS-NI-N--NRDQI-IFMVGRGYLSPDLSK---VRSNCP-----------------------------------------------------------------------------KAMKRLMAECLKKKRDERPL------FP-QILA---SI-------------
--------------------------------YRLEKTLGKGQTGLV---KLGVH---C-------I-TGQ---KVAI-KIV-NRE-K-LSE---SV--L-M-KVER-------EIAILKLI--E------HPH-----VLKLHDVYE--N-----------------------------KKYLY--LVLEH-VSGG--ELFDYLV--------KKG-------------------------RL---TPKEARKFFRQIVSALDFCHS--Y-----SICHRDLKPENLLLD---EKNNI---------RIADFGMASL------------------------QVGDSLL---------ET---SCGSPHYACPEV-IK----------GEKY---DGRRADMWSCGVILFALLV-GA-LP---------------FD-DD-------NL-RQLLEKVKR----GV---FHMPHFIP---------------------------------------------------------------------------PDCQSLLRGMIEVEPEKRLS------LE-QIQKHPW-Y-------------
--------------------------------YRLEKTLGKGQTGLV---KLGVH---C-------V-TCQ---KVAI-KIV-NRE-K-LSE---SV--L-M-KVER-------EIAILKLI--E------HPH-----VLKLHDVYE--N-----------------------------KKYLY--LVLEH-VSGG--ELFDYLV--------KKG-------------------------RL---TPKEARKFFRQIISALDFCHS--H-----SICHRDLKPENLLLD---EKNNI---------RIADFGMASL------------------------QVGDSLL---------ET---SCGSPHYACPEV-IR----------GEKY---DGRKADVWSCGVILFALLV-GA-LP---------------FD-DD-------NL-RQLLEKVKR----GV---FHMPHFIP---------------------------------------------------------------------------PDCQSLLRGMIEVDAARRLT------LE-HIQKHIW-Y-------------
--------------------------------LTFLKELGTGQFGVV---KYGKW---R---------GQY---DVAI-KMI-K-E-G-SM----SE--D-E-FI-E-------EAKVMMNL--S------HEK-----LVQLYGVCT--K-----------------------------QRPIF--IITEY-MANG--CLLNYLR---------EM-----------------------RHRF---QTQQLLEMCKDVCEAMEYLES--K-----QFLHRDLAARNCLVN---DQGVV---------KVSDFGLSRYV-----------------------L--DDEY---------TSSVGSKFPVRWSPPEV-LM-----------YSK---FSSKSDIWAFGVLMWEIYSLGK-MP---------------YE-RF----TNSET-AEHIAQGLR----LY---RPHLAS-----------------------------------------------------------------------------EKVYTIMYSCWHEKADERPT------FK-ILLSN--I--------------
------------------------------FI--FMEVLGSGAFSEV---FLVKQ---R-------L-TGK---LFAL-KCI-KKS-P-AFR---DS--S-L-E--N-------EIAVLKKI--K------HEN-----IVTLEDIYE--S-----------------------------TTHYY--LVMQL-VSGG--ELFDRIL--------ERG-------------------------VY---TEKDASLVIQQVLSAVKYLHE--N-----GIVHRDLKPENLLYLTPEENSKI---------MITDFGLSK-------------------------MEQNGIM---------ST---ACGTPGYVAPEV-LA-----------QKP---YSKAVDCWSIGVITYILLC-GY-PP---------------FY-EE-------TE-SKLFEKIKE----GY---YEFESPFWDDIS-----------------------------------------------------------------------ESAKDFICHLLEKDPNERYT------CE-KALSHPWI--------------
--------------------------------YQLFEELGKGAFSVV---RRCVK---V-------L-AGQ---EYAA-KII-NTK-K-LSA---RD--H-Q-KLER-------EARICRLL--K------HPN-----IVRLHDSIS--E-----------------------------EGHHY--LIFDL-VTGG--ELFEDIV--------ARE-------------------------YY---SEADASHCIQQILEAVLHCHQ--M-----GVVHRDLKPENLLLA---SKLKGA------AVKLADFGLAIEV-----------------------EGEQQAW---------FG---FAGTPGYLSPEV-LR-----------KDP---YGKPVDLWACGVILYILLV-GY-PP---------------FW-DE-------DQ-HRLYQQIKA----GA---YDFPSPEWDTVT-----------------------------------------------------------------------PEAKDLINKMLTINPSKRIT------AA-EALKHPWI--------------
--------------------------------YQLYEDIGKGAFSVV---RRCVK---L-------C-TGH---EYAA-KII-NTK-K-LSA---RD--H-Q-KLER-------EARICRLL--K------HSN-----IVRLHDSIS--E-----------------------------EGFHY--LVFDL-VTGG--ELFEDIV--------ARE-------------------------YY---SEADASHCIQQILEAVLHCHQ--M-----GVVHRDLKPENLLLA---SKCKGA------AVKLADFGLAIEV-----------------------QGDQQAW---------FG---FAGTPGYLSPEV-LR-----------KEA---YGKPVDIWACGVILYILLV-GY-PP---------------FW-DE-------DQ-HKLYQQIKA----GA---YDFPSPEWDTVT-----------------------------------------------------------------------PEAKNLINQMLTINPAKRIT------AH-EALKHPWV--------------
--------------------------------YQLFEELGKGAFSVV---RRCMK---I-------P-TGQ---EYAA-KII-NTK-K-LSA---RD--H-Q-KLER-------EARICRLL--K------HPN-----IVRLHDSIS--E-----------------------------EGFHY--LVFDL-VTGG--ELFEDIV--------ARE-------------------------YY---SEADASHCIQQILESVNHCHL--N-----GIVHRDLKPENLLLA---SKSKGA------AVKLADFGLAIEV-----------------------QGDQQAW---------FG---FAGTPGYLSPEV-LR-----------KDP---YGKPVDMWACGVILYILLV-GY-PP---------------FW-DE-------DQ-HRLYQQIKA----GA---YDFPSPEWDTVT-----------------------------------------------------------------------PEAKDLINKMLTINPAKRIT------AS-EALKHPWI--------------
--------------------------------YTKIEKIGEGTYGVV---YKGRH---K-------T-TGQ---VVAM-KKI-RLE-S-EEE---GV--P-S-TAIR-------EISLLKEL--R------HPN-----IVSLQDVLM--Q-----------------------------DSRLY--LIFEF-LSM---DLKKYLDS-----IPPGQ-------------------------YM---DSSLVKSYLYQILQGIVFCHS--R-----RVLHRDLKPQNLLID---DKGTI---------KLADFGLARAF-----------------------GIPIRVY---------TH---EVVTLWYRSPEV-LL----------GSAR---YSTPVDIWSIGTIFAELAT-KK-PL---------------FH-GD----SEIDQ-LFRIFRALG----TP---NNEVWPEVESLQDYKNTFPKWKP-------------------------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS------GK-MALNHPYF--------------
--------------------------------FQKVEKIGEGTYGVV---YKARN---K-------L-TGE---VVAL-KKI-RLD-T-ETE---GV--P-S-TAIR-------EISLLKEL--N------HPN-----IVKLLDVIH--T-----------------------------ENKLY--LVFEF-LHQ---DLKKFMDA------SALT-------------------------GI---PLPLIKSYLFQLLQGLAFCHS--H-----RVLHRDLKPQNLLIN---TEGAI---------KLADFGLARAF-----------------------GVPVRTY---------TH---EVVTLWYRAPEI-LL----------GCKY---YSTAVDIWSLGCIFAEMVT-RR-AL---------------FP-GD----SEIDQ-LFRIFRTLG----TP---DEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS------AK-AALAHPFF--------------
-------------------------------Y-EPVAEIGVGAYGTV---YKARD---P-------H-SGH---FVAL-KSV-RVP-N-GGGGGGGL--P-I-STVR-------EVALLRRL--EA---FEHPN-----VVRLMDVCA--TSR------------------------TDREIKVT--LVFEH-VDQ---DLRTYLDK------APPP-------------------------GL---PAETIKDLMRQFLRGLDFLHA--N-----CIVHRDLKPENILVT---SGGTV---------KLADFGLARI------------------------YSYQMAL---------TP---VVVTLWYRAPEV-LL-----------QST---YATPVDMWSVGCIFAEMFR-RK-PL---------------FC-GN----SEADQ-LGKIFDLIG----LP---PEDDWPRDVSLPRGAFPPRGPR---------------------------------------------------PVQSVVPEMEESGAQLLLEMLTFNPHKRIS------AF-RALQHSYL--------------
--------------------------------YEKLEKIGEGTYGTV---FKAKN---R-------E-THE---IVAL-KRV-RLD-D-DDE---GV--P-S-SALR-------EICLLKEL--K------HKN-----IVRLHDVLH--S-----------------------------DKKLT--LVFEF-CDQ---DLKKYFD-------SCNG-------------------------DL---DPEIVKSFLFQLLKGLGFCHS--R-----NVLHRDLKPQNLLIN---RNGEL---------KLADFGLARAF-----------------------GIPVRCY---------SA---EVVTLWYRPPDV-LF----------GAKL---YSTSIDMWSAGCIFAELANAGR-PL---------------FP-GN----DVDDQ-LKRIFRLLG----TP---TEEQWPSMTKLPDYKPYPMYPAT-------------------------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS------AE-EALQHPYF--------------
--------------------------------YECVAEIGEGAYGKV---FKARD---L-------K-NGG--RFVAL-KRV-RVQ-T-GEE---GM--P-L-STIR-------EVAVLRHL--ET---FEHPN-----VVRLFDVCT--VSR------------------------TDRETKLT--LVFEH-VDQ---DLTTYLDK------VPEP-------------------------GV---PTETIKDMMFQLLRGLDFLHS--H-----RVVHRDLKPQNILVT---SSGQI---------KLADFGLARI------------------------YSFQMAL---------TS---VVVTLWYRAPEV-LL-----------QSS---YATPVDLWSVGCIFAEMFR-RK-PL---------------FR-GS----SDVDQ-LGKILDVIG----LP---GEEDWPRDVALPRQAFHSKSAQ---------------------------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS------AY-SALSHPYF--------------
--------------------------------YEKLDFLGEGQFATV---YKARD---K-------N-TNQ---IVAI-KKI-KLG-H-RSE---AK--D-G-INRTA----LREIKLLQEL--S------HPN-----IIGLLDAFG--H-----------------------------KSNIS--LVFDF-MET---DLEVIIK-------DNSL-------------------------VL---TPSHIKAYMLMTLQGLEYLHQ--H-----WILHRDLKPNNLLLD---ENGVL---------KLADFGLAKSF-----------------------GSPNRAY---------TH---QVVTRWYRAPEL-LF----------GARM---YGVGVDMWAVGCILAELLL-RV-PF---------------LP-GD----SDLDQ-LTRIFETLG----TP---TEEQWPDMCSLPDYVTFKSFPG--------------------------------------------------IPLHHIFSAAGDDLLDLIQGLFLFNPCARIT------AT-QALKMKYF--------------
--------------------------------YENLGLVGEGSYGMV---MKCRN---K-------D-TGR---IVAI-KKF-LES-D-DDK---MV--K-K-IAMR-------EIKLLKQL--R------HEN-----LVNLLEVCK--K-----------------------------KKRWY--LVFEF-VDHT--ILDDLEL--------FPN-------------------------GL---DYQVVQKYLFQIINGIGFCHS--H-----NIIHRDIKPENILVS---QSGVV---------KLCDFGFARTL-----------------------AAPGEVY---------TD---YVATRWYRAPEL-LV----------GDVK---YGKAVDVWAIGCLVTEMFM-GE-PL---------------FP-GD----SDIDQ-LYHIMMCLG----NL---IPRHQELFNKNPVFAGVRLPEIKE-----------------------------------------------REPLERRYPKLSEVVIDLAKKCLHIDPDKRPF------CA-ELLHHDFF--------------
-------------------------------W-DLVQTLGEGAYGEV---QLAVN---R-------V-TEE---AVAV-KIV-DMK-R-AVD---CP--E-N-I-KK-------EICINKML--N------HEN-----VVKFYGHRR--E-----------------------------GNIQY--LFLEY-CSGG--ELFDRIE--------PDI-------------------------GM---PEPDAQRFFHQLMAGVVYLHG--I-----GITHRDIKPENLLLD---ERDNL---------KISDFGLATVFR---------------------YNNRERLL---------NK---MCGTLPYVAPEL-LK----------RREF---HAEPVDVWSCGIVLTAMLA-GE-LP---------------WD-QP------SDS-CQEYSDWKE----KK---TYLNPWKKI--D-----------------------------------------------------------------------SAPLALLHKILVENPSARIT------IP-DIKKDRW-Y-------------
------------------------------YI--MSKTLGSGACGEV---KLAFE---R-------K-TCK---KVAI-KII-SKR-K-FAI---GS--A-R-EADPALN-VETEIEILKKL--N------HPC-----IIKIKNFF---D-----------------------------AEDYY--IVLEL-MEGG--ELFDKVV--------GNK-------------------------RL---KEATCKLYFYQMLLAVQYLHE--N-----GIIHRDLKPENVLLS---SQEEDC------LIKITDFGHSKI------------------------LGETSLM---------RT---LCGTPTYLAPEV-LVS--------VGTAG---YNRAVDCWSLGVILFICLS-GY-PP---------------FS-EH------RTQ-VSLKDQITS----GK---YNFIPEVWAEVS-----------------------------------------------------------------------EKALDLVKKLLVVDPKARFT------TE-EALRHPWL--------------
--------------------------------YQLVRKLGRGKYSEV---FEAIN---I-------T-NNE---KVVV-KIL-KPV-K-KKK---IK--R--------------EIKILENL-RG------GPN-----IITLADIVK--DP---------------------------VSRTPA--LVFEH-VNNT--DFKQLY-----------Q-------------------------TL---TDYDIRFYMYEILKALDYCHS--M-----GIMHRDVKPHNVMID--HEHRKL---------RLIDWGLAEF------------------------YHPGQEY---------NV---RVASRYFKGPEL-LV----------DYQM---YDYSLDMWSLGCMLASMIF-RK-EP---------------FFHGH----DNYDQ-LVRIAKVLG----TE---DLYDYIDKYNIELDPRFNDILGRHSRK-----------------------------------------RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT------AR-EAMEHPYF--------------
--------------------------------YQLVRKLGRGKYSEV---FEAIN---I-------T-NNE---RVVV-KIL-KPV-K-KKK---IK--R--------------EVKILENL-RG------GTN-----IIKLIDTVK--DP---------------------------VSKTPA--LVFEY-INNT--DFKQLY-----------Q-------------------------IL---TDFDIRFYMYELLKALDYCHS--K-----GIMHRDVKPHNVMID--HQQKKL---------RLIDWGLAEF------------------------YHPAQEY---------NV---RVASRYFKGPEL-LV----------DYQM---YDYSLDMWSLGCMLASMIF-RR-EP---------------FFHGQ----DNYDQ-LVRIAKVLG----TE---ELYGYLKKYHIDLDPHFNDILGQHSRK-----------------------------------------RWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT------AK-EAMEHPYF--------------
--------------------------------YDTGEELGSGQFAVV---KKCRE---K-------S-TGL---QYAA-KFI-KKR-R-TKS---SR--R-G-VSREDI---EREVSILKEI--Q------HPN-----VITLHEVYE--N-----------------------------KTDVI--LILEL-VAGG--ELFDFLA--------EKE-------------------------SL---TEEEATEFLKQILNGVYYLHS--L-----QIAHFDLKPENIMLL---DRNVPKP-----RIKIIDFGLAHK------------------------IDFGNEF---------KN---IFGTPEFVAPEI-VN-----------YEP---LGLEADMWSIGVITYILLS-GA-SP---------------FL-GD-------TK-QETLANVSA----VN---YEFEDEYFSNTS-----------------------------------------------------------------------ALAKDFIRRLLVKDPKKRMT------IQ-DSLQHPWI--------------
--------------------------------YDIGEELGSGQFAIV---KKCRE---K-------S-TGL---EYAA-KFI-KKR-Q-SRA---SR--R-G-VSREEI---EREVSILRQV--L------HHN-----VITLHDVYE--N-----------------------------RTDVV--LILEL-VSGG--ELFDFLA--------QKE-------------------------SL---SEEEATSFIKQILDGVNYLHT--K-----KIAHFDLKPENIMLL---DKNIPIP-----HIKLIDFGLAHE------------------------IEDGVEF---------KN---IFGTPEFVAPEI-VN-----------YEP---LGLEADMWSIGVITYILLS-GA-SP---------------FL-GD-------TK-QETLANITA----VS---YDFDEEFFSQTS-----------------------------------------------------------------------ELAKDFIRKLLVKETRKRLT------IQ-EALRHPWI--------------
--------------------------------YEMGEELGSGQFAIV---RKCRQ---K-------G-TGK---EYAA-KFI-KKR-R-LSS---SR--R-G-VSREEI---EREVNILREI--R------HPN-----IITLHDIFE--N-----------------------------KTDVV--LILEL-VSGG--ELFDFLA--------EKE-------------------------SL---TEDEATQFLKQILDGVHYLHS--K-----RIAHFDLKPENIMLL---DKNVPNP-----RIKLIDFGIAHK------------------------IEAGNEF---------KN---IFGTPEFVAPEI-VN-----------YEP---LGLEADMWSIGVITYILLS-GA-SP---------------FL-GE-------TK-QETLTNISA----VN---YDFDEEYFSNTS-----------------------------------------------------------------------ELAKDFIRRLLVKDPKRRMT------IA-QSLEHSWI--------------
--------------------------------YEIDSLIGKGSFGQV---VKAYD---R-------V-EQE---WVAI-KII-KNK-K-AFL---NQ--A-Q-I----------EVRLLELM-NK------HDTEMKYYIVHLKRHFM--F-----------------------------RNHLC--LVFEM-LSY---NLYDLLR---------NT-------------------------NFRGVSLNLTRKFAQQMCTALLFLATPEL-----SIIHCDLKPENILLCN-PKRSAI---------KIVDFGSSCQ--------------------------LGQRI---------YQ---YIQSRFYRSPEV-LL-----------GMP---YDLAIDMWSLGCILVEMHT-GE-PL---------------FS-GA----NEVDQ-MNKIVEVLG----IP---PAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT--------------RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQ------PY-YALQHSFF--------------
--------------------------------YEIDSLIGKGSFGQV---VKAYD---H-------Q-TQE---LVAI-KII-KNK-K-AFL---NQ--A-Q-I----------ELRLLELM-NQ------HDTEMKYYIVHLKRHFM--F-----------------------------RNHLC--LVFEL-LSY---NLYDLLR---------NT-------------------------HFRGVSLNLTRKLAQQLCTALLFLATPEL-----SIIHCDLKPENILLCN-PKRSAI---------KIVDFGSSCQ--------------------------LGQRI---------YQ---YIQSRFYRSPEV-LL-----------GTP---YDLAIDMWSLGCILVEMHT-GE-PL---------------FS-GS----NEVDQ-MNRIVEVLG----IP---PAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGT--------------RRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARIS------PL-GALQHGFF--------------
--------------------------------YEVLKVIGKGSFGQV---VKAYD---H-------K-VHQ---HVAL-KMV-RNE-K-RFH---RQ--A-A-E----------EIRILEHL--RKQDKDNTMN-----VIHMLENFT--F-----------------------------RNHIC--MTFEL-LSM---NLYELIKK------NKFQ-------------------------GF---SLPLVRKFAHSILQCLDALHK--N-----RIIHCDLKPENILLK---QQGRSG-------IKVIDFGSSC--------------------------YEHQRV---------YT---YIQSRFYRAPEV-IL-----------GAR---YGMPIDMWSLGCILAELLT-GY-PL---------------LP-GE----DEGDQ-LACMIELLG----MP---SQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNG-------------------GRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMT------PG-QALRHPWL--------------
-------------------------------F-KKIKVLGSGAFGTV---YKGLW---IP---EGEK-VKI---PVAI-KEL-R-E-A-TS----PKANK-E-IL-D-------EAYVMASV--D------NPH-----VCRLLGICL--------------------------------TSTVQ--LITQL-MPFG--CLLDYVR---------EH-----------------------KDNI---GSQYLLNWCVQIAKGMNYLED--R-----RLVHRDLAARNVLVK---TPQHV---------KITDFGLAKLL-------------G---------A--EEKE---------YHAEGGKVPIKWMALES-IL-----------HRI---YTHQSDVWSYGVTVWELMTFGS-KP---------------YD-GI----PASEI-SSILEKGER----LP---QPPICT-----------------------------------------------------------------------------IDVYMIMVKCWMIDADSRPK------FR-ELI----IEF------------
-------------------------------F-KEIELIGSGGFGQV---FKAKH---R-------I-DGK---TYVI-KRV-KYN-N-EKA---ER-----------------EVKALAKL--D------HVN-----IVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEF-CDKG--TLEQWIEK------RRGE-------------------------KL---DKVLALELFEQITKGVDYIHS--K-----KLIHRDLKPSNIFLV---DTKQV---------KIGDFGLVTS------------------------LKNDGKR---------TR---SKGTLRYMSPEQ-IS-----------SQD---YGKEVDLYALGLILAELLH-VCDTA---------------FE-T------------SKFFTDLR----DG---IISDIFDK----------------------------------------------------------------------------KEKTLLQKLLSKKPEDRPN------TS-EILR----TLT-----------
EDENSKSQNQDEDCNEKNGCHESEPSVTTEAV-----------------------------------------------------------------------------------------------------------------------------------------------------HYLY--IQMEY-CEKS--TLRDTID--------QGL-------------------------YR---DTVRLWRLFREILDGLAYIHE--K-----GMIHRDLKPVNIFLD---SDDHV---------KIGDFGLATDHLAFSADSKQ-----DDQTGDLIKSDPSGHL---------TG---MVGTALYVSPEVQGS----------TKSA---YNQKVDLFSLGIIFFEMSY-HP-MV---------------TA-SE-------RI-FVLNQLRDP----TS---PKFPEDFDDGEH-----------------------------------------------------------------------AKQKSVISWLLNHDPAKRPT------AT-ELLKSEL-L-------------
-------------------------------I-SIDKVVGAGEFGEV---CSGRL---K----LPSK-KEI---SVAI-KTL-K-V-G-YT----EKQRR-D-FL-G-------EASIMGQF--D------HPN-----IIRLEGVVT--K-----------------------------SKPVM--IVTEY-MENG--SLDSFLR---------KH-----------------------DAQF---TVIQLVGMLRGIASGMKYLSD--M-----GYVHRDLAARNILIN---SNLVC---------KVSDFGLSRVL-------------E---------D--DPEA--------AYTTRGGKIPIRWTSPEA-IA-----------YRK---FTSASDVWSYGIVLWEVMSYGE-RP---------------YW-EM----SNQDV-IKAVDEGYR----LP---PPMDCP-----------------------------------------------------------------------------AALYQLMLDCWQKDRNNRPK------FE-QIVSIL----------------
--------------------------------ITIERVIGAGEFGEV---CSGRL---K----LPGK-REL---PVAI-KTL-K-V-G-YT----EKQRR-D-FL-G-------EASIMGQF--D------HPN-----IIHLEGVVT--K-----------------------------SKPVM--IVTEY-MENG--SLDTFLK---------KN-----------------------DGQF---TVIQLVGMLRGISAGMKYLSD--M-----GYVHRDLAARNILIN---SNLVC---------KVSDFGLSRVL-------------E---------D--DPEA--------AYTTRGGKIPIRWTAPEA-IA-----------FRK---FTSASDVWSYGIVMWEVVSYGE-RP---------------YW-EM----TNQDV-IKAVEEGYR----LP---SPMDCP-----------------------------------------------------------------------------AALYQLMLDCWQKERNSRPK------FD-EIVNML----------------
-------------------------------V-KIEEVIGAGEFGEV---YKGRL---K----LPGK-REI---YVAI-KTL-K-A-G-YS----EKQRR-D-FL-S-------EASIMGQF--D------HPN-----IIRLEGVVT--K-----------------------------SRPVM--IITEF-MENG--ALDSFLR---------QN-----------------------DGQF---TVIQLVGMLRGIAAGMKYLAE--M-----NYVHRDLAARNILVN---SNLVC---------KVSDFGLSRYLQ----------DDT---------S--DPTY---------TSSLGGKIPVRWTAPEA-IA-----------YRK---FTSASDVWSYGIVMWEVMSFGE-RP---------------YW-DM----SNQDV-INAIEQDYR----LP---PPMDCP-----------------------------------------------------------------------------AALHQLMLDCWQKDRNSRPR------FA-EIVNTL----------------
--------------------------------LTLGKPLGEGCFGQV---VMAEA---VGIDKDKPK-EAV---TVAV-KML-K-D-D-AT----EKDLS-D-LV-S-------EMEMMKMIG-K------HKN-----IINLLGACT--Q-----------------------------DGPLY--VIVEY-ASKG--NLREYLR---------ARRPPGMEY--------SYDINRVPEEQM---TFKDLVSCTYQLARGMEYLAS--Q-----KCIHRDLAARNVLVT---ENNVM---------KIADFGLARDI-------------N---------N--IDYY---------KKTTNGRLPVKWMAPEA-LF-----------DRV---YTHQSDVWSFGVLMWEIFTLGG-SP---------------YP-GI----PVEEL-FKLLKEGHR----MD---KPANCT-----------------------------------------------------------------------------NELYMMMRDCWHAVPSQRPT------FK-QLVEDL----------------
------------------------------LR--VRRVLAEGGFAFV---YEAQD---V-------G-SGR---EYAL-KRL-LSN-E-EEK---NR--A-I---IQ-------EVCFMKKL-SG------HPN-----IVQFCSAAS--IGKEE---------------------SDTGQAEFL--LLTEL-CKG---QLVEFLKK-----MESRG-------------------------PL---SCDTVLKIFYQTCRAVQHMHR--QK---PPIIHRDLKVENLLLS---NQGTI---------KLCDFGSATTISHYPDY-----------SWSAQRRALVEEE---------IT---RNTTPMYRTPEI-IDL--------YSNFP---IGEKQDIWALGCILYLLCF-RQ-HP---------------FE-DG-------AK-LRIVNGKYS-----I---PPHDTQY----------------------------------------------------------------------------TVFHSLIRAMLQVNPEERLS------IA-EVVHQ---L-------------
----------------------------FLDF----RVLGKGGFGEV---SACQM---K-------A-TGK---LYAC-KKL-NKK-R-LKK---RK--G-Y-QGAM------VEKKILMKV--H------SRF-----IVSLAYAFE--T-----------------------------KADLC--LVMTI-MNGG--DIRYHIYNV----NEENP-------------------------GF---PEPRALFYTAQIICGLEHLHQ--R-----RIVYRDLKPENVLLD---NDGNV---------RISDLGLAVEL-----------------------LDGQSKT---------KG---YAGTPGFMAPEL-LQ-----------GEE---YDFSVDYFALGVTLYEMIA-AR-GP---------------FR-AR---GEKVEN-KELKHRIIS----EP---VKYPDKFS---------------------------------------------------------------------------QASKDFCEALLEKDPEKRLG------FR-D-------ETCDKLRAHPLF--
------------------------------FR--HYRVLGKGGFGEV---CACQV---R-------A-TGK---MYAC-KKL-QKK-R-IKK---RK--G-E-AMAL------NEKRILEKV--Q------SRF-----VVSLAYAYE--T-----------------------------KDALC--LVLTI-MNGG--DLKFHIYN------LGNP-------------------------GF---DEQRAVFYAAELCCGLEDLQR--E-----RIVYRDLKPENILLD---DRGHI---------RISDLGLATE------------------------IPEGQRV---------RG---RVGTVGYMAPEV-VN-----------NEK---YTFSPDWWGLGCLIYEMIQ-GH-SP---------------FK-KY----KEKVK-WEEVDQRIK----ND---TEEYSE---KFS-----------------------------------------------------------------------EDAKSICRMLLTKNPSKRLGCR-GEGAA-GVKQHPV-F-------------
-------------------------------F-RQYRVLGKGGFGEV---CACQV---R-------A-TGK---MYAC-KKL-EKK-R-IKK---RK--G-E-AMAL------NEKQILEKV--N------SRF-----VVSLAYAYE--T-----------------------------KDALC--LVLTL-MNGG--DLKFHIYH------MGQA-------------------------GF---PEARAVFYAAEICCGLEDLHR--E-----RIVYRDLKPENILLD---DHGHI---------RISDLGLAVH------------------------VPEGQTI---------KG---RVGTVGYMAPEV-VK-----------NER---YTFSPDWWALGCLLYEMIA-GQ-SP---------------FQ-QR----KKKIK-REEVERLVK-----E---VPEEYSER--FS-----------------------------------------------------------------------PQARSLCSQLLCKDPAERLGCR-GGSAR-EVKEHPLF--------------
--------------------------------YTDIKVIGNGSFGVV---YQARL---A-------E-TRE---LVAI-KKV-LQD-K-RFK---NR-----------------ELQIMRKL--D------HCN-----IVRLRYFFY--SSG-------------------------EKKDELYLNLVLEY-VPETVYRVARHFT-------KAKL-------------------------TI---PILYVKVYMYQLFRSLAYIHS--Q-----GVCHRDIKPQNLLVD--PDTAVL---------KLCDFGSAKQ------------------------LVRGEPN---------VS---YICSRYYRAPEL-IF----------GATD---YTSSIDVWSAGCVLAELLL-GQ-PI---------------FP-GD----SGVDQ-LVEIIKVLG----TP---TREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS------PL-EACAHSFF--------------
--------------------------------YTDTKVIGNGSFGVV---YQAKL---C-------D-SGE---LVAI-KKV-LQD-K-RFK---NR-----------------ELQIMRKL--D------HCN-----IVRLRYFFY--SSG-------------------------EKKDEVYLNLVLDY-VPETVYRVA---RHY----SRAKQ-------------------------TL---PVIYVKLYMYQLFRSLAYIHS--F-----GICHRDIKPQNLLLD--PDTAVL---------KLCDFGSAKQ------------------------LVRGEPN---------VS---YICSRYYRAPEL-IF----------GATD---YTSSIDVWSAGCVLAELLL-GQ-PI---------------FP-GD----SGVDQ-LVEIIKVLG----TP---TREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT------PL-EACAHSFF--------------
--------------------------------YEVLEFLGRGTFGQV---AKCWK---R-------S-TKE---IVAI-KIL-KNH-P-SYA---RQ--G-Q-I----------EVSILSRL--S------SENADEYNFVRSYECFQ--H-----------------------------KNHTC--LVFEM-LEQ---NLYDFLKQ------NKFS-------------------------PL---PLKYIRPILQQVATALMKLKS--L-----GLIHADLKPENIMLV---DPVRQPY-----RVKVIDFGSAS-------------------------HVSKAVC---------ST---YLQSRYYRAPEI-IL-----------GLP---FCEAIDMWSLGCVIAELFL-GW-PL---------------YP-GA----SEYDQ-IRYISQTQG----LP---AEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKE------ARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRIT------PL-KTLNHQFV--------------
--------------------------------YEVLEFLGRGTFGQV---VKCWK---R-------G-TNE---IVAI-KIL-KNH-P-SYA---RQ--G-Q-I----------EVSILARL--STE-SADDYN-----FVRAYECFQ--H-----------------------------KNHTC--LVFEM-LEQ---NLYDFLKQ------NKFS-------------------------PL---PLKYIRPVLQQVATALMKLKS--L-----GLIHADLKPENIMLV---DPSRQPY-----RVKVIDFGSAS-------------------------HVSKAVC---------ST---YLQSRYYRAPEI-IL-----------GLP---FCEAIDMWSLGCVIAELFL-GW-PL---------------YP-GA----SEYDQ-IRYISQTQG----LP---AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKE------ARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRIT------PI-ETLNHPFV--------------
--------------------------------YEVLDFLGRGTFGQV---VKCWK---R-------G-TNE---IVAI-KIL-KNH-P-SYA---RQ--G-Q-I----------EVSILARL--S------TENADEYNFVRAYECFQ--H-----------------------------RNHTC--LVFEM-LEQ---NLYDFLKQ------NKFS-------------------------PL---PLKVIRPILQQVATALKKLKS--L-----GLIHADLKPENIMLV---DPVRQPY-----RVKVIDFGSAS-------------------------HVSKTVC---------ST---YLQSRYYRAPEI-IL-----------GLP---FCEAIDMWSLGCVIAELFL-GW-PL---------------YP-GA----LEYDQ-IRYISQTQG----LP---GEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKE------ARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRIT------PA-ETLNHPFV--------------
--------------------------------YDIIEVLGKGTFGEV---AKGWR---R-------S-TGE---MVAI-KIL-KND-A-YRN---RI--I-K-N----------ELKLLHCM--RGL-DPEEAH-----VIRFLEFFH--D-----------------------------ALKFY--LVFEL-LEQ---NLFEFQK---------EN-------------------------NFAPLPARHIRTVTLQVLTALARLKE--L-----AIIHADLKPENIMLV---DQTRCPF-----RVKVIDFGSASIF-----------------------SEVRYVK---------EP---YIQSRFYRAPEI-LL-----------GLP---FCEKVDVWSLGCVMAELHL-GW-PL---------------YP-GN----NEYDQ-VRYICETQG----LP---KPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERIS------PS-AALRHPFV--------------
-----------------------------IGS----RKLGEGSFAKV---REGLH---V-------L-TGE---KVAI-KVI-DKK-R-AKK---DT--Y-V-TKNLR-----REGQIQQMI--R------HPN-----ITQLLDILE--T-----------------------------ENSYY--LVMEL-CPGG--NLMHKIY--------EKK-------------------------RL---EESEARRYIRQLISAVEHLHR--A-----GVVHRDLKIENLLLD---EDNNI---------KLIDFGLSNCAG---------------------ILGYSDPF---------ST---QCGSPAYAAPEL-LA-----------RKK---YGPKIDVWSIGVNMYAMLT-GT-LP---------------FT-VE-----PFSL-RALYQKMVD-----K---EMNPLPTQ--LS-----------------------------------------------------------------------TGAISFLRSLLEPDPVKRPN------IQ-QALANRWL--------------
--------------------------------YTTIRQLGDGTYGSV---LLGRS---I-------E-SGE---LIAI-KKM-KRK-F-YSW---EE--C---MNLR-------EVKSLKKL--N------HAN-----VVKLKEVIR--E-----------------------------NDHLY--FIFEY-MKE---NLYQLIK-------ERNK-------------------------LF---PESAIRNIMYQILQGLAFIHK--H-----GFFHRDLKPENLLCM---GPELV---------KIADFGLARE------------------------IRSKPPY---------TD---YVSTRWYRAPEV-LL----------RSTN---YSSPIDVWAVGCIMAEVYT-LR-PL---------------FP-GA----SEIDT-IFKICQVLG----TP---KKTDWPEGYQLSSAMNFRWPQCV------------------------------------------------PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPT------AS-QALRYPYF--------------
-----------------------------VGG----NKMGEGGFGVV---YKGYV---N-------N-TT-----VAV-KKL-AAM-V-DIT---TE--ELK-QQFD------QEIKVMAKC--Q------HEN-----LVELLGFSS--D-----------------------------GDDLC--LVYVY-MPNG--SLLDRLSC-----LDGTP-------------------------PL---SWHMRCKIAQGAANGINFLHE--N-----HHIHRDIKSANILLD---EAFTA---------KISDFGLARASE---------------------KFAQTVMT---------SR---IVGTTAYMAPEA-LR------------GE---ITPKSDIYSFGVVLLEIIT-GL-PA---------------VD-EH----REPQL-LLDIKEEIE----DE---EKTIEDYIDKKMNDAD---------------------------------------------------------------STSVEAMYSVASQCLHEKKNKRPD------IK-KVQQ----LLQ-----------
--------------------------------LKFLQQLGKGNFGSV---EMCRY---DP---LQDN-TGE---VVAV-KKL-Q-H-S-TE-----EHLR-D-FE-R-------EIEILKSL--Q------HDN-----IVKYKGVCYSAG-----------------------------RRNLK--LIMEY-LPYG--SLRDYLQ---------KH-----------------------KERI---DHIKLLQYTSQICKGMEYLGT--K-----RYIHRDLATRNILVE---NENRV---------KIGDFGLTKVL------------PQ---------D--KEYY---------KVKEPGESPIFWYAPES-LT-----------ESK---FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQG-QM----IVFHL-IELLKNNGR----LP---RPDGCP-----------------------------------------------------------------------------DEIYMIMTECWNNNVNQRPS------FR-DLA----LRV------------
-------------------------------L-KYISQLGKGNFGSV---ELCRY---DP---LGDN-TGA---LVAV-KQL-Q-H-S-GP----DQ-QR-D-FQ-R-------EIQILKAL--H------SDF-----IVKYRGVSYGPG-----------------------------RQSLR--LVMEY-LPSG--CLRDFLQ---------RH-----------------------RARL---DASRLLLYSSQICKGMEYLGS--R-----RCVHRDLAARNILVE---SEAHV---------KIADFGLAKLL------------PL---------D--KDYY---------VVREPGQSPIFWYAPES-LS-----------DNI---FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCER-DV-P--ALCRL-LELLEEGQR----LP---APPACP-----------------------------------------------------------------------------AEVHELMKLCWAPSPQDRPS------FS-ALGP---QL-------------
------------------------------LI--HGEVLGKGFFGQA---IKVTH---K---------ATG---KVMVMKEL---I-R-CD----EETQK-T-FL-T-------EVKVMRSL--D------HPN-----VLKFIGVLY--K-----------------------------DKKLN--LLTEY-IEGG--TLKDFLR---------SM------------------------DPF---PWQQKVRFAKGIASGMAYLHS--M-----CIIHRDLNSHNCLIK---LDKTV---------VVADFGLSRLIVEERKRAPMEKATT---------------KKRTLRKNDRKKRYTVVGNPYWMAPEM-LN-----------GKS---YDETVDIFSFGIVLCEIIGQVY-AD---------------PD-CL-P--RTLDF-GLNVKLFWE----KF---VPTDCP-----------------------------------------------------------------------------PAFFPLAAICCRLEPESRPA------FS-KLED---SF-------------
--------------------------------IKLVKRLGAGQFGEV---WMGYY---N---------NST---KVAV-KTL-K-P-G-TM----SV--Q-A-FL-E-------EANLMKTL--Q------HDK-----LVRLYAVVT--R-----------------------------EEPIY--IITEY-MAKG--SLLDFLK---------SD----------------------EGGKV---LLPKLIDFSAQIAEGMAYIER--K-----NYIHRDLRAANVLVS---ESLMC---------KIADFGLARVI-----------------------E--DNEY---------TAREGAKFPIKWTAPEA-IN-----------FGC---FTIKSDVWSFGILLYEIVTYGK-IP---------------YP-GR----TNADV-MTALSQGYR----MP---RVENCP-----------------------------------------------------------------------------DELYDIMKMCWKEKAEERPT------FD-YLQSV--L--------------
-----------------------------ERV-----VLGKGTYGIV---YAGRD---L-------S-NQV---RIAI-KEI-PER-D-SRY---SQ--P-L-H--E-------EIALHKYL--K------HRN-----IVQYLGSVS--E-----------------------------NGYIK--IFMEQ-VPGG--SLSALLR-------SKWG-------------------------PM---KEPTIKFYTKQILEGLKYLHE--N-----QIVHRDIKGDNVLVN--TYSGVV---------KISDFGTSKRL-----------------------AGVNPCT---------ET---FTGTLQYMAPEI-ID---------QGPRG---YGAPADIWSLGCTIIEMAT-SK-PP---------------FH-EL------GEP-QAAMFKVGM----FK---IHPEIPEALS-------------------------------------------------------------------------AEARAFILSCFEPDPHKRAT------TA-ELLREGF-L-------------
--------------------------------WRLGKLLGQGAFGRV---YLCYD---V-------D-TGR---ELAV-KQV-QFD-P-DSP---ET--S-K-EVNAL----ECEIQLLKNL--L------HER-----IVQYYGCLR--DP---------------------------QEKTLS--IFMEY-MPGG--SIKDQLK--------AYG-------------------------AL---TENVTRKYTRQILEGVHYLHS--N-----MIVHRDIKGANILRD---STGNV---------KLGDFGASKRLQ--------------------TICLSGTGM---------KS---VTGTPYWMSPEV-IS-----------GEG---YGRKADIWSVACTVVEMLT-EK-PP---------------WA-EF-------EA-MAAIFKIAT----QP---TNPKLPPHVS-------------------------------------------------------------------------DYTRDFLKRIFV-EAKLRPS------AD-ELLRHMF-V-------------
-------------------------------W-RRGKLLGQGAFGRV---YLCYD---V-------D-TGR---ELAS-KQV-QFD-P-DSP---ET--S-K-EVSAL----ECEIQLLKNL--Q------HER-----IVQYYGCLR--DR---------------------------AEKTLT--IFMEY-MPGG--SVKDQLK--------AYG-------------------------AL---TESVTRKYTRQILEGMSYLHS--N-----MIVHRDIKGANILRD---SAGNV---------KLGDFGASKRLQ--------------------TICMSGTGM---------RS---VTGTPYWMSPEV-IS-----------GEG---YGRKADVWSLGCTVVEMLT-EK-PP---------------WA-EY-------EA-MAAIFKIAT----QP---TNPQLPSHIS-------------------------------------------------------------------------EHGRDFLRRIFV-EARQRPS------AE-ELLTHHF-A-------------
-------------------------------W-QRGNKIGEGQYGKV---YTCIS---V-------D-TGE---LMAM-KEI-RFQ-P-NDH---KT--I-K-ETAD-------ELKIFEGI--K------HPN-----LVRYFGVEL--H-----------------------------REEMY--IFMEY-CDEG--TLEEVS----------RL-------------------------GL---QEHVIRLYSKQITIAINVLHE--H-----GIVHRDIKGANIFLT---SSGLI---------KLGDFGCSVKLKN-------------------NAQTMPGEV---------NS---TLGTAAYMAPEV-ITR--------AKGEG---HGRAADIWSLGCVVIEMVT-GK-RP---------------WH-EY-----EHNF-QIMYKVGMG----HK---PPIPERLS---------------------------------------------------------------------------PEGKDFLSHCLESDPKMRWT------AS-QLLDHSFV--------------
--------------------------------YQNLKPIGSGAQGIV---CAAYD---A-------V-LDR---NVAI-KKL-SRP-F-QNQ---TH--A-K-RAYR-------ELVLMKCV--N------HKN-----IISLLNVFT--PQKT-----------------------LEEFQDVY--LVMEL-MDA---NLCQVIQ----------M-------------------------EL---DHERMSYLLYQMLCGIKHLHS--A-----GIIHRDLKPSNIVVK---SDCTL---------KILDFGLART------------------------AGTSFMM---------TP---YVVTRYYRAPEV-IL-----------GMG---YKENVDIWSVGCIMGEMVR-HK-IL---------------FP-GR----DYIDQ-WNKVIEQLG----TP---CPEFMKKLQPTVRNYVENRPKYAGLTFPK------------------------------------LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS------VD-DALQHPYI--------------
--------------------------------YQNLSPVGSGAYGSV---CAAFD---T-------K-TGL---RVAV-KKL-SRP-F-QSI---IH--A-K-RTYR-------ELRLLKHM--K------HEN-----VIGLLDVFT--PARS-----------------------LEEFNDVY--LVTHL-MGA---DLNNIVK---------CQ-------------------------KL---TDDHVQFLIYQILRGLKYIHS--A-----DIIHRDLKPSNLAVN---EDCEL---------KILDFGLAR--------------------------HTDDEM---------TG---YVATRWYRAPEI-ML----------NWMH---YNQTVDIWSVGCIMAELLT-GR-TL---------------FP-GT----DHIDQ-LKLILRLVG----TP---GAELLKKISSESARNYIQSLTQMP-----------------------------------------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT------AA-QALAHAYF--------------
--------------------------------YEIIETIGNGAYGVV---SSARR---R-------L-TGQ---QVAI-KKI-PNA-F-DVV---TN--A-K-RTLR-------ELKILKHF--K------HDN-----IIAIKDILR--PTVP-----------------------YGEFKSVY--VVLDL-MES---DLHQIIH--------SSQ-------------------------PL---TLEHVRYFLYQLLRGLKYMHS--A-----QVIHRDLKPSNLLVN---ENCEL---------KIGDFGMARGLCT-------------------SPAEHQYFM---------TE---YVATRWYRAPEL-ML----------SLHE---YTQAIDLWSVGCIFGEMLA-RR-QL---------------FP-GK----NYVHQ-LQLIMMVLG----TP---SPAVIQAVGAERVRAYIQSLPPRQ-----------------------------------------------PVPWETVYPGADRQALSLLGRMLRFEPSARIS------AA-AALRHPFL--------------
--------------------------------YQNLKPIGSGAQGIV---CAAYD---A-------I-LER---NVAI-KKL-SRP-F-QNQ---TH--A-K-RAYR-------ELVLMKCV--N------HKN-----IIGLLNVFT--PQKS-----------------------LEEFQDVY--IVMEL-MDA---NLCQVIQ----------M-------------------------EL---DHERMSYLLYQMLCGIKHLHS--A-----GIIHRDLKPSNIVVK---SDCTL---------KILDFGLART------------------------AGTSFMM---------TP---YVVTRYYRAPEV-IL-----------GMG---YKENVDLWSVGCIMGEMVC-HK-IL---------------FP-GR----DYIDQ-WNKVIEQLG----TP---CPEFMKKLQPTVRTYVENRPKYAGYSFEK------------------------------------LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS------VD-EALQHPYI--------------
--------------------------------YQQLKPIGSGAQGIV---CAAFD---T-------V-LGI---NVAV-KKL-SRP-F-QNQ---TH--A-K-RAYR-------ELVLLKCV--N------HKN-----IISLLNVFT--PQKT-----------------------LEEFQDVY--LVMEL-MDA---NLCQVIH----------M-------------------------EL---DHERMSYLLYQMLCGIKHLHS--A-----GIIHRDLKPSNIVVK---SDCTL---------KILDFGLART------------------------ACTNFMM---------TP---YVVTRYYRAPEV-IL-----------GMG---YKENVDIWSVGCIMGELVK-GC-VI---------------FQ-GT----DHIDQ-WNKVIEQLG----TP---SAEFMKKLQPTVRNYVENRPKYPGIKFEE------------------------------------LFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS------VD-EALRHPYI--------------
-----------------------------KVT---SQVLGLGINGKV---LQIFN---K-------R-TQE---KFAL-KML-QDC-P-KAR--------------R-------EVELHWRA-SQ------CPH-----IVRIVDVYE--NLY-------------------------AGRKCLL--IVMEC-LDGG--ELFSRIQD------RGDQ-------------------------AF---TEREASEIMKSIGEAIQYLHS--I-----NIAHRDVKPENLLYT---SKRPNA------ILKLTDFGFAKE------------------------TTSHNSL---------TT---PCYTPYYVAPEV-LG-----------PEK---YDKSCDMWSLGVIMYILLC-GY-PP---------------FY-SN---HGLAIS-PGMKTRIRM----GQ---YEFPNPEWSEVS-----------------------------------------------------------------------EEVKMLIRNLLKTEPTQRMT------IT-EFMNHPWI--------------
--------------------------------YRLLKTIGKGNFAKV---KLARH---I-------L-TGK---EVAV-KII-DKT-Q-LNS---SS--L-Q-KLFR-------EVRIMKVL--N------HPN-----IVKLFEVIE--T-----------------------------EKTLY--LVMEY-ASGG--EVFDYLV--------AHG-------------------------RM---KEKEARAKFRQIVSAVQYCHQ--K-----FIVHRDLKAENLLLD---ADMNI---------KIADFGFSNE------------------------FTFGNKL---------DT---FCGSPPYAAPEL-FQ----------GKKY---DGPEVDVWSLGVILYTLVS-GS-LP---------------FD-GQ-------NL-KELRERVLR----GK---YRIPFYMS---------------------------------------------------------------------------TDCENLLKKFLILNPSKRGT------LE-QIMKDRWM--------------
--------------------------------YRLLRTIGKGNFAKV---KLARH---I-------L-TGR---EVAI-KII-DKT-Q-LNP---SS--L-Q-KLFR-------EVRIMKGL--N------HPN-----IVKLFEVIE--T-----------------------------EKTLY--LVMEY-ASAG--EVFDYLV--------SHG-------------------------RM---KEKEARAKFRQIVSAVHYCHQ--K-----NIVHRDLKAENLLLD---AEANI---------KIADFGFSNE------------------------FTLGSKL---------DT---FCGSPPYAAPEL-FQ----------GKKY---DGPEVDIWSLGVILYTLVS-GS-LP---------------FD-GH-------NL-KELRERVLR----GK---YRVPFYMS---------------------------------------------------------------------------TDCESILRRFLVLNPAKRCT------LE-QIMKDKWI--------------
--------------------------------LTLGAQIGEGEFGAV---LQGEY---L----------GQ---KVAV-KNI-K-C-D-VT----AQ----A-FL-D-------ETAVMTKM--Q------HEN-----LVRLLGVIL--------------------------------HQGLY--IVMEH-VSKG--NLVNFLR---------TR----------------------GRALV---NTAQLLQFSLHVAEGMEYLES--K-----KLVHRDLAARNILVS---EDLVA---------KVSDFGLAKAE-----------------------------R---------KGLDSSRLPVKWTAPEA-LK-----------HGK---FTSKSDVWSFGVLLWEVFSYGR-AP---------------YP-KM----SLKEV-SEAVEKGYR----ME---PPEGCP-----------------------------------------------------------------------------GPVHVLMSSCWEAEPARRPP------FR-KLAEKL----------------
--------------------------------YELHETIGTGGFAKV---KLACH---I-------L-TGE---MVAI-KIM-DKN-T-LGS---DL--P-R-IKT--------EIEALKNL--R------HQH-----ICQLYHVLE--T-----------------------------ANKIF--MVLEY-CPGG--ELFDYII--------SQD-------------------------RL---SEEETRVVFRQIVSAVAYVHS--Q-----GYAHRDLKPENLLFD---EYHKL---------KLIDFGLCAKP----------------------KGNKDYHL---------QT---CCGSLAYAAPEL-IQ----------GKSY---LGSEADVWSMGILLYVLMC-GF-LP---------------FD-DD-------NV-MALYKKIMR----GK---YDVPKWLS---------------------------------------------------------------------------PSSILLLQQMLQVDPKKRIS------MK-NLLNHPWI--------------
--------------------------------YRIRGEIGSGNFSQV---KLGIH---S-------L-TKE---KVAI-KIL-DKT-K-LDQ---KT--Q-R-LLSR-------EISSMEKL--H------HPN-----IIRLYEVVE--T-----------------------------LSKLH--LVMEY-AGGG--ELFGKIS--------TEG-------------------------KL---SEPESKLIFSQIVSAVKHMHE--N-----QIIHRDLKAENVFYT---SNTCV---------KVGDFGFSTV------------------------SKKGEML---------NT---FCGSPPYAAPEL-FR----------DEHY---IGIYVDIWALGVLLYFMVT-GT-MP---------------FR-AE-------TV-AKLKKSILE----GT---YSVPPHV----S-----------------------------------------------------------------------EPCHRLIRGVLQQIPTERYG------ID-CIMNDEWM--------------
--------------------------------YEVLYTIGTGSYGRC---QKIRR---K-------S-DGK---ILVW-KEL-DYG-S-MTE---AE--K-Q-MLVS-------EVNLLREL--K------HPN-----IVRYYDRII--DR---------------------------TNTTLY--IVMEY-CEGG--DLASVITKG----TKERQ-------------------------YL---DEEFVLRVMTQLTLALKECHR--RSDGGHTVLHRDLKPANVFLD---GKQNV---------KLGDFGLARIL-----------------------NHDTSFA---------KT---FVGTPYYMSPEQ-MN-----------RMS---YNEKSDIWSLGCLLYELCA-LM-PP---------------FT-AF-------SQ-KELAGKIRE----GK---FRRIPYRY---S-----------------------------------------------------------------------DELNEIITRMLNLKDYHRPS------VE-EILENPL-I-------------
--------------------------------YELQETLGKGTYGKV---KRATE---R-------F-SGR---VVAI-KSI-RKD-K-IKD---EQ--D-M-VHIR------REIEIMSSL--N------HPH-----IISIYEVFE--N-----------------------------KDKIV--IIMEY-ASKG--ELYDYIS--------ERR-------------------------RL---SERETRHFFRQIVSAVHYCHK--N-----GVVHRDLKLENILLD---DNCNI---------KIADFGLSNL------------------------YQKDKFL---------QT---FCGSPLYASPEI-VN----------GRPY---RGPEVDSWALGVLLYTLVY-GT-MP---------------FD-GF-------DH-KNLIRQISS----GE---YREPTQP----------------------------------------------------------------------------SDARGLIRWMLMVNPDRRAT------IE-DIANHWW-V-------------
--------------------------------YEFLETLGKGTYGKV---KKARE---S-------S-GR----LVAI-KSI-RKD-K-IKD---EQ--D-L-MHIR------REIEIMSSL--N------HPH-----IIAIHEVFE--N-----------------------------SSKIV--IVMEY-ASRG--DLYDYIS--------ERQ-------------------------QL---SEREARHFFRQIVSAVHYCHQ--N-----RVVHRDLKLENILLD---ANGNI---------KIADFGLSNL------------------------YHQGKFL---------QT---FCGSPLYASPEI-VN----------GKPY---TGPEVDSWSLGVLLYILVH-GT-MP---------------FD-GH-------DH-KILVKQISN----GA---YREPPK-----P-----------------------------------------------------------------------SDACGLIRWLLMVNPTRRAT------LE-DVASHWW-V-------------
--------------------------------YELQEVIGSGATAVV---QAAYC---A-------P-KKE---KVAI-KRI-NLE-K-CQT---SM--D-E--LLK-------EIQAMSQC--H------HPN-----IVSYYTSFV--V-----------------------------KDELW--LVMKL-LSGG--SVLDIIKHIVAKGEHKSG-------------------------VL---DESTIATILREVLEGLEYLHK--N-----GQIHRDVKAGNILLG---EDGSV---------QIADFGVSAFLAT------------------GGDITRNKVR---------KT---FVGTPCWMAPEV-ME----------QVRG---YDFKADIWSFGITAIELAT-GA-AP---------------YH-KY----PPMKV-LMLTLQNDP----PS---LETGVQDKE--MLK------------------------------------------------------------------KYGKSFRKMISLCLQKDPEKRPT------AA-ELLRHKFF--------------
--------------------------------YTRYEKIGQGASGTV---FTATD---V-------A-LGQ---EVAI-KQI-NLQ-K-QPK---KE--L-I-I--N-------EILVMKEL--K------NPN-----IVNFLDSYL--V-----------------------------GDELF--VVMEY-LAGG--SLTDVVT---------ET-------------------------CM---DEAQIAAVCRECLQALEFLHA--N-----QVIHRDIKSDNVLLG---MEGSV---------KLTDFGFCAQI-----------------------TPEQSKR---------ST---MVGTPYWMAPEV-VT-----------RKA---YGPKVDIWSLGIMAIEMVE-GE-PP---------------YL-NE----NPLRA-LYLIATNGT----PE---LQNPEKLS---------------------------------------------------------------------------PIFRDFLNRCLEMDVEKRGS------AK-ELLQHPFL--------------
--------------------------------YTRFEKIGQGASGTV---YTALD---I-------A-TGQ---EVAI-KQM-NLQ-Q-QPK---KE--L-I-I--N-------EILVMREN--K------NPN-----IVNYLDSYL--V-----------------------------GDELW--VVMEY-LAGG--SLTDVVT---------ET-------------------------CM---DEGQIAAVCRECLQALDFLHS--N-----QVIHRDIKSDNILLG---MDGSV---------KLTDFGFCAQI-----------------------TPEQSKR---------ST---MVGTPYWMAPEV-VT-----------RKA---YGPKVDIWSLGIMAIEMVE-GE-PP---------------YL-NE----NPLRA-LYLIATNGT----PE---LQNPERLS---------------------------------------------------------------------------AVFRDFLNRCLEMDVDRRGS------AK-ELLQHPFL--------------
----------------------------DNFI-----KIGEGSTGIV---CIATV---R-------S-SGK---LVAV-KKM-DLR-K-QQR---RE--L----LFN-------EVVIMRDY--Q------HEN-----VVEMYNSYL--V-----------------------------GDELW--VVMEF-LEGG--ALTDIVT---------HT-------------------------RM---NEEQIAAVCLAVLQALSVLHA--Q-----GVIHRDIKSDSILLT---HDGRV---------KLSDFGFCAQV-----------------------SKEVPRR---------KS---LVGTPYWMAPEL-IS-----------RLP---YGPEVDIWSLGIMVIEMVD-GE-PP---------------YF-NE----PPLKA-MKMIRDNLP----PR---LKNLHKVS---------------------------------------------------------------------------PSLKGFLDRLLVRDPAQRAT------AA-ELLKHPFL--------------
----------------------------DSYV-----KIGEGSTGIV---CLARE---K-------H-SGR---QVAV-KMM-DLR-K-QQR---RE--L----LFN-------EVVIMRDY--Q------HFN-----VVEMYKSYL--V-----------------------------GEELW--VLMEF-LQGG--ALTDIVS---------QV-------------------------RL---NEEQIATVCEAVLQALAYLHA--Q-----GVIHRDIKSDSILLT---LDGRV---------KLSDFGFCAQI-----------------------SKDVPKR---------KS---LVGTPYWMAPEV-IS-----------RSL---YATEVDIWSLGIMVIEMVD-GE-PP---------------YF-SD----SPVQA-MKRLRDSPP----PK---LKNSHKVS---------------------------------------------------------------------------PVLRDFLERMLVRDPQERAT------AQ-ELLDHPFL--------------
----------------------------ANFI-----KIGEGSTGIV---CIATE---K-------H-TGK---QVAV-KKM-DLR-K-QQR---RE--L----LFN-------EVVIMRDY--H------HDN-----VVDMYSSYL--V-----------------------------GDELW--VVMEF-LEGG--ALTDIVT---------HT-------------------------RM---NEEQIATVCLSVLRALSYLHN--Q-----GVIHRDIKSDSILLT---SDGRI---------KLSDFGFCAQV-----------------------SKEVPKR---------KS---LVGTPYWMAPEV-IS-----------RLP---YGTEVDIWSLGIMVIEMID-GE-PP---------------YF-NE----PPLQA-MRRIRDSLP----PR---VKDLHK----VS-----------------------------------------------------------------------SVLRGFLDLMLVREPSQRAT------AQ-ELLGHPFL--------------
-------------------------------Y-IKLDKLGEGTYATV---YKGKS---K-------L-TDN---LVAL-KEI-RLE-H-EEG---AP--C---TAIR-------EVSLLKDL--K------HAN-----IVTLHDIIH--T-----------------------------EKSLT--LVFEY-LDK---DLKQYLD-------DCGN-------------------------II---NMHNVKLFLFQLLRGLAYCHR--Q-----KVLHRDLKPQNLLIN---ERGEL---------KLADFGLARAK-----------------------SIPTKTY---------SN---EVVTLWYRPPDI-LL----------GSTD---YSTQIDMWGVGCIFYEMAT-GR-PL---------------FP-GS----TVEEQ-LHFIFRILG----TP---TEETWPGILSNEEFKTYNYPKYR------------------------------------------------AEALLSHAPRLDSDGADLLTKLLQFEGRNRIS------AE-DAMKHPFF--------------
-------------------------------Y-IKLEKLGEGTYATV---YKGRS---K-------L-TEN---LVAL-KEI-RLE-H-EEG---AP--C---TAIR-------EVSLLKDL--K------HAN-----IVTLHDIVH--T-----------------------------DKSLT--LVFEY-LDK---DLKQYMD-------DCGN-------------------------IM---SMHNVKLFLYQILRGLAYCHR--R-----KVLHRDLKPQNLLIN---EKGEL---------KLADFGLARAK-----------------------SVPTKTY---------SN---EVVTLWYRPPDV-LL----------GSSE---YSTQIDMWGVGCIFFEMAS-GR-PL---------------FP-GS----TVEDE-LHLIFRLLG----TP---SQETWPGISSNEEFKNYNFPKYK------------------------------------------------PQPLINHAPRLDSEGIELITKFLQYESKKRVS------AE-EAMKHVYF--------------
--------------------------------YVKLDKLGEGTYATV---FKGRS---K-------L-TEN---LVAL-KEI-RLE-H-EEG---AP--C---TAIR-------EVSLLKNL--K------HAN-----IVTLHDLIH--T-----------------------------DRSLT--LVFEY-LDS---DLKQYLD--------HCG-------------------------NL--MSMHNVKIFMFQLLRGLAYCHH--R-----KILHRDLKPQNLLIN---ERGEL---------KLADFGLARAK-----------------------SVPTKTY---------SN---EVVTLWYRPPDV-LL----------GSTE---YSTPIDMWGVGCIHYEMAT-GR-PL---------------FP-GS----TVKEE-LHLIFRLLG----TP---TEETWPGVTAFSEFRTYSFPCYL------------------------------------------------PQPLINHAPRLDTDGIHLLSSLLLYESKSRMS------AE-AALSHSYF--------------
-------------------------------F-KFGKILGEGSFSTV---VLARE---L-------A-TSR---EYAI-KIL-EKR-H-IIK---EN--K-VPYVTR-------ERDVMSRL--D------HPF-----FVKLYFTFQ--D-----------------------------DEKLY--FGLSY-AKNG--ELLKYIR--------KIG-------------------------SF---DETCTRFYTAEIVSALEYLHG--K-----GIIHRDLKPENILLN---EDMHI---------QITDFGTAKVLS---------------------PESKQARA---------NS---FVGTAQYVSPEL-LT-----------EKS---ACKSSDLWALGCIIYQLVA-GL-PP---------------FR-AG-------NE-YLIFQKIIK----LE---YDFPEKFF---------------------------------------------------------------------------PKARDLVEKLLVLDATKRLG------CE-EM------EGYGPLKAHPF---
--------------------------------YEKLEKLGEGSYATV---YKGKS---K-------V-NGK---LVAL-KVI-RLQ-E-EEG---TP--F---TAIR-------EASLLKGL--K------HAN-----IVLLHDIIH--T-----------------------------KETLT--LVFEY-VHT---DLCQYMD-------KHPG-------------------------GL---HPDNVKLFLFQLLRGLSYIHQ--R-----YILHRDLKPQNLLIS---DTGEL---------KLADFGLARAK-----------------------SVPSHTY---------SN---EVVTLWYRPPDV-LL----------GSTE---YSTCLDMWGVGCIFVEMIQ-GV-AA---------------FP-GM---KDIQDQ-LERIFLVLG----TP---NEDTWPGVHSLPHFKPERFTLYSS----------------------------------------------KNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLS------AQ-AALSHEYF--------------
--------------------------------YEPKEILGRGVSSVV---RRCIH---K-------P-TSQ---EYAV-KVI-DVT-G-GGS---FS--P-E-EVRELREATLKEVDILRKV-SG------HPN-----IIQLKDTYE--T-----------------------------NTFFF--LVFDL-MKRG--ELFDYLT--------EKV-------------------------TL---SEKETRKIMRALLEVICTLHK--L-----NIVHRDLKPENILLD---DNMNI---------KLTDFGFSCQ------------------------LEPGERL---------RE---VCGTPSYLAPEI-IECS-----MNEDHPG---YGKEVDMWSTGVIMYTLLA-GS-PP---------------FW-HR-------KQ-MLMLRMIMS----GN---YQFGSPEWDDYS-----------------------------------------------------------------------DTVKDLVSRFLVVQPQNRYT------AE-EALAHPFF--------------
-----------------------------YDP---KDVIGRGVSSVV---RRCVH---R-------A-TGH---EFAV-KIM-EVT-A-ERL---SP--E-Q-LEEVREA-TRRETHILRQV-AG------HPH-----IITLIDSYE--S-----------------------------SSFMF--LVFDL-MRKG--ELFDYLT--------EKV-------------------------AL---SEKETRSIMRSLLEAVSFLHA--N-----NIVHRDLKPENILLD---DNMQI---------RLSDFGFSCH------------------------LEPGEKL---------RE---LCGTPGYLAPEI-LKCS-----MDETHPG---YGKEVDLWACGVILFTLLA-GS-PP---------------FW-HR-------RQ-ILMLRMIME----GQ---YQFSSPEWDDRS-----------------------------------------------------------------------STVKDLISRLLQVDPEARLT------AE-QALQHPFF--------------
--------------------------------YRLGPLLGKGGFGTV---FAGHR---L-------T-DRL---QVAI-KVI-PRN-R-VLG---WS--P-L-SDSVTC---PLEVALLWKV--GAG--GGHPG-----VIRLLDWFE--T-----------------------------QEGFM--LVLERPLPAQ--DLFDYIT--------EKG-------------------------PL---GEGPSRCFFGQVVAAIQHCHS--R-----GVVHRDIKDENILID--LRRGCA---------KLIDFGSGA-------------------------LLHDEPY---------TD---FDGTRVYSPPEW-IS----------RHQY---HALPATVWSLGILLYDMVC-GD-IP---------------FE-RD--------------QEILE----AE---LHFPAHVS---------------------------------------------------------------------------PDCCALIRRCLAPKPSSRPS------LE-EILLDPWM--------------
--------------------------------YQVGAVLGSGGFGTV---YAGSR---I-------A-DGL---PVAV-KHV-VKE-R-VTE---WG--S-L-GGATV----PLEVVLLRKV--GAA--GGARG-----VIRLLDWFE--R-----------------------------PDGFL--LVLER-PEPA-QDLFDFIT--------ERG-------------------------AL---DEPLARRFFAQVLAAVRHCHS--C-----GVVHRDIKDENLLVD--LRSGEL---------KLIDFGSGA-------------------------LLKDTVY---------TD---FDGTRVYSPPEW-IR----------YHRY---HGRSATVWSLGVLLYDMVC-GD-IP---------------FE-QD--------------EEILR----GR---LLFRRRVS---------------------------------------------------------------------------PECQQLIRWCLSLRPSERPS------LD-QIAAHPWM--------------
------------------------------FR--CCAVLGRGHFGKV---LLAEY---K-------N-TNE---MFAI-KAL-KKG-D-IVA---RD--E-V-DSLM------CEKRIFETV--NS---VRHPF-----LVNLFACFQ--T-----------------------------KEHVC--FVMEY-AAGG--DLMMHIH---------TD-------------------------VF---SEPRAVFYAACVVLGLQYLHE--H-----KIVYRDLKLDNLLLD---TEGFV---------KIADFGLCKEG-----------------------MGYGDRT---------ST---FCGTPEFLAPEV-LT-----------ETS---YTRAVDWWGLGVLIYEMLV-GE-SP---------------FP-GD-------DE-EEVFDSIVN----DE---VRYPRFLS---------------------------------------------------------------------------TEAISIMRRLLRRNPERRLGAS-EKDAE-DVKKHPFF--------------
------------------------------YV--RGRFLGKGGFAKC---FEISD---A-------D-TKE---VFAG-KIV-PKS-L-LLK---PH--Q-R-EKMS------MEISIHRSL--A------HQH-----VVGFHGFFE--D-----------------------------NDFVF--VVLEL-CRRR--SLLELHK--------RRK-------------------------AL---TEPEARYYLRQIVLGCQYLHR--N-----RVIHRDLKLGNLFLN---EDLEV---------KIGDFGLATKV-----------------------EYDGERK---------KT---LCGTPNYIAPEV-LS-----------KKG---HSFEVDVWSIGCIMYTLLV-GK-PP---------------FE-TS-------CL-KETYLRIKK----NE---YSIPKHIN---------------------------------------------------------------------------PVAASLIQKMLQTDPTARPT------IN-ELLNDEFF--------------
-------------------------------Y-CRGKVLGKGGFAKC---YEMTD---L-------T-NNK---VYAA-KII-PHS-R-VAK---PH--Q-R-EKID------KEIELHRIL--H------HKH-----VVQFYHYFE--D-----------------------------KENIY--ILLEY-CSRR--SMAHILK--------ARK-------------------------VL---TEPEVRYYLRQIVSGLKYLHE--Q-----EILHRDLKLGNFFIN---EAMEL---------KVGDFGLAARL-----------------------EPLEHRR---------RT---ICGTPNYLSPEV-LN-----------KQG---HGCESDIWALGCVMYTMLL-GR-PP---------------FE-TT-------NL-KETYRCIRE----AR---YTMPSSLL---------------------------------------------------------------------------APAKHLIASMLSKNPEDRPS------LD-DIIRHDFF--------------
-------------------------------F-KVGNLLGKGSFAGV---YRAES---I-------H-TGL---EVAI-KMI-DKK-A-MYK---AG--M-V-QRVQ------NEVKIHCQL--K------HPS-----ILELYNYFE--D-----------------------------SNYVY--LVLEM-CHNG--EMNRYLK-------NRVK-------------------------PF---SENEARHFMHQIITGMLYLHS--H-----GILHRDLTLSNLLLT---RNMNI---------KIADFGLATQL-----------------------KMPHEKH---------YT---LCGTPNYISPEI-AT-----------RSA---HGLESDVWSLGCMFYTLLI-GR-PP---------------FD-TD-------TV-KNTLNKVVL----AD---YEMPSFLS---------------------------------------------------------------------------IEAKDLIHQLLRRNPADRLS------LS-SVLDHPFM--------------
-------------------------------Y-ILGDTLGVGTFGKV---KVGKH---E-------L-TGH---KVAV-KIL-NRQ-K-IRS---LD--V-V-GKIR------REIQNLKLF--R------HPH-----IIKLYQVIS--T-----------------------------PSDIF--MVMEY-VSGG--ELFDYIC--------KNG-------------------------RL---DEKESRRLFQQILSGVDYCHR--H-----MVVHRDLKPENVLLD---AHMNA---------KIADFGLSNM------------------------MSDGEFL---------RT---SCGSPNYAAPEV-IS----------GRLY---AGPEVDIWSSGVILYALLC-GT-LP---------------FD-DD-------HV-PTLFKKICD----GI---FYTPQYLN---------------------------------------------------------------------------PSVISLLKHMLQVDPMKRAT------IK-DIREHEWF--------------
--------------------------------YVLGDTLGVGTFGKV---KIGEH---Q-------L-TGH---KVAV-KIL-NRQ-K-IRS---LD--V-V-GKIK------REIQNLKLF--R------HPH-----IIKLYQVIS--T-----------------------------PTDFF--MVMEY-VSGG--ELFDYIC--------KHG-------------------------RV---EEMEARRLFQQILSAVDYCHR--H-----MVVHRDLKPENVLLD---AHMNA---------KIADFGLSNM------------------------MSDGEFL---------RT---SCGSPNYAAPEV-IS----------GRLY---AGPEVDIWSCGVILYALLC-GT-LP---------------FD-DE-------HV-PTLFKKIRG----GV---FYIPEYLN---------------------------------------------------------------------------RSVATLLMHMLQVDPLKRAT------IK-DIREHEWF--------------
-------------------------------F-NFLMVLGKGSFGKV---MLSER---K-------G-TDE---LYAV-KIL-KKD-V-VIQ---DD--D-V-ECTM------VEKRVLALP-GK------PPF-----LTQLHSCFQ--T-----------------------------MDRLY--FVMEY-VNGG--DLMYHIQ--------QVG-------------------------RF---KEPHAVFYAAEIAIGLFFLQS--K-----GIIYRDLKLDNVMLD---SEGHI---------KIADFGMCKEN-----------------------IWDGVTT---------KT---FCGTPDYIAPEI-IA-----------YQP---YGKSVDWWAFGVLLYEMLA-GQ-AP---------------FE-GE-------DE-DELFQSIME----HN---VAYPKSMS---------------------------------------------------------------------------KEAVAICKGLMTKHPGKRLG------C----------GPEGERDIKEHAFF
------------------------------FI--FHKVLGKGSFGKV---LLGEL---K-------G-RGE---YFAI-KAL-KKD-V-VLI---DD--D-V-ECTM------VEKRVLTLA-AE------NPF-----LTHLICTFQ--T-----------------------------KDHLF--FVMEF-LNGG--DLMYHIQ--------DKG-------------------------RF---ELYRATFYAAEIMCGLQFLHS--K-----GIIYRDLKLDNVLLD---RDGHI---------KIADFGMCKEN-----------------------IFGESRA---------ST---FCGTPDYIAPEI-LQ-----------GLK---YTFSVDWWSFGVLLYEMLI-GQ-SP---------------FH-GD-------DE-DELFESIRV----DT---PHYPRWIT---------------------------------------------------------------------------KESKDILEKLFEREPTKRLG-----VTG-NIKIHPFF--------------
--------------------------------FEFIRVLGKGSFGKV---MLARV---K-------E-TGD---LYAV-KVL-KKD-V-ILQ---DD--D-V-ECTM------TEKRILSLA-RN------HPF-----LTQLFCCFQ--T-----------------------------PDRLF--FVMEF-VNGG--DLMFHIQ--------KSR-------------------------RF---DEARARFYAAEIISALMFLHD--K-----GIIYRDLKLDNVLLD---HEGHC---------KLADFGMCKEG-----------------------ICNGVTT---------AT---FCGTPDYIAPEI-LQ-----------EML---YGPAVDWWAMGVLLYEMLC-GH-AP---------------FE-AE-------NE-DDLFEAILN----DE---VVYPTWLH---------------------------------------------------------------------------EDATGILKSFMTKNPTMRLGSLTQGGEH-AILRHPF-F-------------
------------------------------FI--LHKMLGKGSFGKV---FLAEF---K-------K-TNQ---FFAI-KAL-KKD-V-VLM---DD--D-V-ECTM------VEKRVLSLA-WE------HPF-----LTHMFCTFQ--T-----------------------------KENLF--FVMEY-LNGG--DLMYHIQ--------SCH-------------------------KF---DLSRATFYAAEIILGLQFLHS--K-----GIVYRDLKLDNILLD---KDGHI---------KIADFGMCKEN-----------------------MLGDAKT---------NT---FCGTPDYIAPEI-LL-----------GQK---YNHSVDWWSFGVLLYEMLI-GQ-SP---------------FH-GQ-------DE-EELFHSIRM----DN---PFYPRWLE---------------------------------------------------------------------------KEAKDLLVKLFVREPEKRLG------VRGDIRQHPLF--------------
-------------------------------F-DLIRVIGRGSYAKV---LLVRL---K-------K-NDQ---IYAM-KVV-KKE-L-VHD---DE--D-I-DWVQ------TEKHVFEQA-SS------NPF-----LVGLHSCFQ--T-----------------------------TSRLF--LVIEY-VNGG--DLMFHMQ--------RQR-------------------------KL---PEEHARFYAAEICIALNFLHE--R-----GIIYRDLKLDNVLLD---ADGHI---------KLTDYGMCKEG-----------------------LGPGDTT---------ST---FCGTPNYIAPEI-LR-----------GEE---YGFSVDWWALGVLMFEMMA-GR-SP---------------FD-IITDNPDMNTE-DYLFQVILE----KP---IRIPRFLS---------------------------------------------------------------------------VKASHVLKGFLNKDPKERLGCRPQTGF----------SDIKSHAFF-----
------------------------------PD----EVLGSGQFGIV---YGGKH---R-------K-TGR---DVAI-KII-DKL-R-FPT---KQ--E-S-QLRN-------EVAILQNL--H------HPG-----VVNLECMFE--T-----------------------------PERVF--VVMEK-LHGD--MLEMILS-------SEKG-------------------------RL---PEHITKFLITQILVALRHLHF--K-----NIVHCDLKPENVLLA---SADPFP------QVKLCDFGFARI------------------------IGEKSFR---------RS---VVGTPAYLAPEV-LR-----------NKG---YNRSLDMWSVGVIIYVSLS-GT-FP---------------FN-ED----------EDIHDQIQN----AA---FMYPPNPWKEIS-----------------------------------------------------------------------HEAIDLINNLLQVKMRKRYS------VD-KTLSHPWL--------------
------------------------------PD----EVLGSGQFGVV---YGGKH---R-------K-TGR---DVAV-KVI-DKL-R-FPT---KQ--E-S-QLRN-------EVAILQSL--R------HPG-----IVNLECMFE--T-----------------------------PEKVF--VVMEK-LHGD--MLEMILS-------SEKG-------------------------RL---PERLTKFLITQILVALRHLHF--K-----NIVHCDLKPENVLLA---SADPFP------QVKLCDFGFARI------------------------IGEKSFR---------RS---VVGTPAYLAPEV-LL-----------NQG---YNRSLDMWSVGVIMYVSLS-GT-FP---------------FN-ED----------EDINDQIQN----AA---FMYPASPWSHIS-----------------------------------------------------------------------AGAIDLINNLLQVKMRKRYS------VD-KSLSHPWL--------------
-----------------------------FAD----EVLGSGQFGIV---YGGKH---R-------K-TGR---DVAI-KVI-DKM-R-FPT---KQ--E-S-QLRN-------EVAILQNL--H------HPG-----IVNLECMFE--T-----------------------------PERVF--VVMEK-LHGD--MLEMILS-------SEKS-------------------------RL---PERITKFMVTQILVALRNLHF--K-----NIVHCDLKPENVLLA---SAEPFP------QVKLCDFGFARI------------------------IGEKSFR---------RS---VVGTPAYLAPEV-LR-----------SKG---YNRSLDMWSVGVIIYVSLS-GT-FP---------------FN-ED----------EDINDQIQN----AA---FMYPPNPWREIS-----------------------------------------------------------------------GEAIDLINNLLQVKMRKRYS------VD-KSLSHPWL--------------
-------------------------------F-NIIDTLGVGGFGRV---ELVQL---KS------E-ESK---TFAM-KIL-KKR-H-IVD---TR--Q-Q-EHIR------SEKQIMQGA--H------SDF-----IVRLYRTFK--D-----------------------------SKYLY--MLMEA-CLGG--ELWTILR--------DRG-------------------------SF---EDSTTRFYTACVVEAFAYLHS--K-----GIIYRDLKPENLILD---HRGYA---------KLVDFGFAKK------------------------IGFGKKT---------WT---FCGTPEYVAPEI-IL-----------NKG---HDISADYWSLGILMYELLT-GS-PP---------------FS-GP-------DP-MKTYNIILR----GI---DMIEFPKKIA-------------------------------------------------------------------------KNAANLIKKLCRDNPSERLGNL-KNGVK-DIQKHKWF--------------
----------------------------YNVY----GYTGQGVFSNV---VRARD---N-------ARANQ---EVAV-KII-RNN-E-LMQ---KT--G-----LK-------ELEFLKKL--NDADPDDKFH-----CLRLFRHFY--H-----------------------------KQHLC--LVFEP-LSM---NLREVLKK-----YGKDV-------------------------GL---HIKAVRSYSQQLFLALKLLKR--C-----NILHADIKPDNILVN---ESKTI--------LKLCDFGSAS-------------------------HVADNDI---------TP---YLVSRFYRAPEI-II-----------GKS---YDYGIDMWSVGCTLYELYT-GK-IL---------------FP-GK----TNNHM-LKLAMDLKG----KM---PNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVM------------------STINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRIS------IN-QALQHAFI--------------
-------------------------------L-VLGKTLGEGEFGKV---VKATA---FH--LKGRA-GYT---TVAV-KML-K-E-N-AS----PSELR-D-LL-S-------EFNVLKQV--N------HPH-----VIKLYGACS--Q-----------------------------DGPLL--LIVEY-AKYG--SLRGFLR---------ESRKVGPGYLGSGGSRNSSSLDHPDERAL---TMGDLISFAWQISQGMQYLAE--M-----KLVHRDLAARNILVA---EGRKM---------KISDFGLSRDV-------------Y---------E--EDSY---------VKRSQGRIPVKWMAIES-LF-----------DHI---YTTQSDVWSFGVLLWEIVTLGG-NP---------------YP-GI----PPERL-FNLLKTGHR----ME---RPDNCS-----------------------------------------------------------------------------EEMYRLMLQCWKQEPDKRPV------FA-DISKDL----------------
-----------------------------LES----AELDSGGFGKV---SLCFH---R---------TQG---LMIM-KTVYK-G-P-NC----IEHNE-A-LL-E-------EAKMMNRL--R------HSR-----VVKLLGVII--E-----------------------------EGKYS--LVMEY-MEKG--NLMHVLK---------AE------------------------MST---PLSVKGRIILEIIEGMCYLHG--K-----GVIHKDLKPENILVD---NDFHI---------KIADLGLASFKMWS------KLNNE-------------EHNELR---EVDGTAKKNGGTLYYMAPEH-LN-----------DVNA-KPTEKSDVYSFAVVLWAIFA-NK-EP---------------YE-NA-I--CEQQL-IMCIKSGNR----PDVDDITEYCP-----------------------------------------------------------------------------REIISLMKLCWEANPEARPT------FP-GIEEK--F--------------
--------------------------------FELLKVLGQGSFGKVFLVRKVTR---P-------D-SGH---LYAM-KVL-KKA-T-LKV---RD--R-V-RTKM-------ERDILADV--N------HPF-----VVKLHYAFQ--T-----------------------------EGKLY--LILDF-LRGG--DLFTRLS--------KEV-------------------------MF---TEEDVKFYLAELALGLDHLHS--L-----GIIYRDLKPENILLD---EEGHI---------KLTDFGLSKEA-----------------------IDHEKKA---------YS---FCGTVEYMAPEV-VN-----------RQG---HSHSADWWSYGVLMFEMLT-GS-LP---------------FQ-GK-------DR-KETMTLILK----AK---LGMPQFLS---------------------------------------------------------------------------TEAQSLLRALFKRNPANRLGSG-PDGAE-EIKRHV--FY------------
--------------------------------FELLKVLGQGSYGKV---FLVRK---V-------K-GSDAGQLYAM-KVL-KKA-T-LKV---RD--R-V-RSKM-------ERDILAEV--N------HPF-----IVKLHYAFQ--T-----------------------------EGKLY--LILDF-LRGG--DLFTRLS--------KEV-------------------------MF---TEEDVKFYLAELALALDHLHS--L-----GIIYRDLKPENILLD---EEGHI---------KITDFGLSKEA-----------------------IDHDKRA---------YS---FCGTIEYMAPEV-VN-----------RRG---HTQSADWWSFGVLMFEMLT-GS-LP---------------FQ-GK-------DR-KETMALILK----AK---LGMPQFLS---------------------------------------------------------------------------GEAQSLLRALFKRNPCNRLGAG-IDGVE-EIKRHPFF--------------
--------------------------------FELLKVLGQGSFGKV---FLVKK---I-------S-GSDARQLYAM-KVL-KKA-T-LKV---RD--R-V-RTKM-------ERDILVEV--N------HPF-----IVKLHYAFQ--T-----------------------------EGKLY--LILDF-LRGG--DLFTRLS--------KEV-------------------------MF---TEEDVKFYLAELALALDHLHS--L-----GIIYRDLKPENILLD---EEGHI---------KLTDFGLSKES-----------------------IDHEKKA---------YS---FCGTVEYMAPEV-VN-----------RRG---HTQSADWWSFGVLMFEMLT-GT-LP---------------FQ-GK-------DR-KETMTMILK----AK---LGMPQFLS---------------------------------------------------------------------------PEAQSLLRMLFKRNPANRLGAG-PDGVE-EIKRHSFF--------------
--------------------------------FELLKVLGQGSFGKV---FLVRK---K-------T-GPDAGQLYAM-KVL-KKA-S-LKV---RD--R-V-RTKM-------ERDILVEV--N------HPF-----IVKLHYAFQ--T-----------------------------EGKLY--LILDF-LRGG--DVFTRLS--------KEV-------------------------LF---TEEDVKFYLAELALALDHLHQ--L-----GIVYRDLKPENILLD---EIGHI---------KLTDFGLSKES-----------------------VDQEKKA---------YS---FCGTVEYMAPEV-VN-----------RRG---HSQSADWWSYGVLMFEMLT-GT-LP---------------FQ-GK-------DR-NETMNMILK----AK---LGMPQFLS---------------------------------------------------------------------------AEAQSLLRMLFKRNPANRLGS---EGVE-EIKRHLFF--------------
--------------------------------FELLRVLGKGGYGKV---FQVRKVTGA-------N-TGK---IFAM-KVL-KKA-M-IVR---NA--K-D-TAHTK-----AERNILEEV--K------HPF-----IVDLIYAFQ--T-----------------------------GGKLY--LILEY-LSGG--ELFMQLE--------REG-------------------------IF---MEDTACFYLAEISMALGHLHQ--K-----GIIYRDLKPENIMLN---HQGHV---------KLTDFGLCKES-----------------------IHDGTVT---------HT---FCGTIEYMAPEI-LM-----------RSG---HNRAVDWWSLGALMYDMLT-GA-PP---------------FT-GE-------NR-KKTIDKILK----CK---LNLPPYLT---------------------------------------------------------------------------QEARDLLKKLLKRNAASRLGAG-PGDAG-EVQAHPFF--------------
--------------------------------YELVRELGKGTYGKV---DLVVY---K-------G-TGT---KMAL-KFV-NKS-K-TKL---KN--F-----LR-------EVSITNSL-SS------SPF-----IIKVFDVVF--E----------------------------TEDCYV--FAQEY-APAG--DLFDIIP--------PQV-------------------------GL---PEDTVKRCVQQLGLALDFMHG--R-----QLVHRDIKPENVLLFD-RECRRV---------KLADFGMTR--------------------------RVGCRV---------KR---VSGTIPYTAPEV-CQAG------RADGLA---VDTGVDVWAFGVLIFCVLT-GN-FP---------------WE-AA----SGADAFFEEFVRWQR----GR---LPGLPSQWRRFT-----------------------------------------------------------------------EPALRMFQRLLALEPERRGP------AK-EVF-----RFLKH---------
--------------------------------YDIERTLGKGNFAVV---KLARH---R-------V-TKT---QVAI-KII-DKT-R-LDS---SN--L-E-KIYR-------EVQLMKLL--N------HPH-----IIKLYQVME--T-----------------------------KDMLY--IVTEF-AKNG--EMFDYLT--------SNG-------------------------HL---SENEARKKFWQILSAVEYCHD--H-----HIVHRDLKTENLLLD---GNMDI---------KLADFGFGNF------------------------YKSGEPL---------ST---WCGSPPYAAPEV-FE----------GKEY---EGPQLDIWSLGVVLYVLVC-GS-LP---------------FD-GP-------NL-PTLRQRVLE----GR---FRIPFFMS---------------------------------------------------------------------------QDCESLIRRMLVVDPARRIT------IA-QIRQHRWM--------------
--------------------------------YDIEGTLGKGNFAVV---KLGRH---R-------I-TKT---EVAI-KII-DKS-Q-LDA---VN--L-E-KIYR-------EVQIMKML--D------HPH-----IIKLYQVME--T-----------------------------KSMLY--LVTEY-AKNG--EIFDYLA--------NHG-------------------------RL---NESEARRKFWQILSAVDYCHG--R-----KIVHRDLKAENLLLD---NNMNI---------KIADFGFGNF------------------------FKSGELL---------AT---WCGSPPYAAPEV-FE----------GQQY---EGPQLDIWSMGVVLYVLVC-GA-LP---------------FD-GP-------TL-PILRQRVLE----GR---FRIPYFMS---------------------------------------------------------------------------EDCEHLIRRMLVLDPSKRLT------IA-QIKEHKWM--------------
--------------------------------WEIIGELGDGAFGKV---YKAQN---K-------E-TSV---LAAA-KVI-DTK-S-EEE---LE--D-Y-M--V-------EIDILASC--D------HPN-----IVKLLDAFY--Y-----------------------------ENNLW--ILIEF-CAGG--AVDAVML-------ELER-------------------------PL---TESQIQVVCKQTLDALNYLHD--N-----KIIHRDLKAGNILFT---LDGDI---------KLADFGVSAKN-----------------------TRTIQRR---------DS---FIGTPYWMAPEV-VMCE------TSKDRP---YDYKADVWSLGITLIEMAE-IE-PP---------------HH-EL----NPMRV-LLKIAKSEP----PT---LAQPSRWS---------------------------------------------------------------------------SNFKDFLKKCLEKNVDARWT------TS-QLLQHPFV--------------
--------------------------------YDLDKTLGRGHFAVV---KLARH---V-------F-TGE---KVAV-KVI-DKT-K-LDT---LA--T-G-HLFQ-------EVRCMKLV--Q------HPN-----IVRLYEVID--T-----------------------------QTKLY--LILEL-GDGG--DMFDYIM-------KHEE-------------------------GL---NEDLAKKYFAQIVHAISYCHK--L-----HVVHRDLKPENVVFF--EKQGLV---------KLTDFGFSNK------------------------FQPGKKL---------TT---SCGSLAYSAPEI-LL----------GDEY---DAPAVDIWSLGVILFMLVC-GQ-PP---------------FQ-EA-------ND-SETLTMIMD----CK---YTVPSHVS---------------------------------------------------------------------------KECKDLITRMLQRDPKRRAS------LE-EIENHPWL--------------
-----------------------------YLM---GDLLGEGSYGKV---KEVLD---S-------E-TLC---RRAV-KIL-KKK-K-LRR---IP--N-G-EANVK-----KEIQLLRRL--R------HKN-----VIQLVDVLY--NE---------------------------EKQKMY--MVMEY-CVCGMQEMLDSVP---------EK-------------------------RF---PVCQAHGYFCQLIDGLEYLHS--Q-----GIVHKDIKPGNLLLT---TGGTL---------KISDLGVAEALH---------------------PFAADDTC---------RT---SQGSPAFQPPEI-AN---------GLDTF---SGFKVDIWSAGVTLYNITT-GL-YP---------------FE-GD-------NI-YKLFENIGK----GS---YAIPGDCG---------------------------------------------------------------------------PPLSDLLKGMLEYEPAKRFS------IR-QIRQHSWF--------------
-----------------------------LCP---GRELGRGKFAVV---RKCIK---K-------D-SGK---EFAA-KFM-RKR-R-KGQ---DC--R-M-EIIH-------EIAVLELA-QD------NPW-----VINLHEVYE--T-----------------------------ASEMI--LVLEY-AAGG--EIFDQCVA------DREE-------------------------AF---KEKDVQRLMRQILEGVHFLHT--R-----DVVHLDLKPQNILLT---SESPLG------DIKIVDFGLSRI------------------------LKNSEEL---------RE---IMGTPEYVAPEI-LS-----------YDP---ISMATDMWSIGVLTYVMLT-GI-SP---------------FL-GN-------DK-QETFLNISQ----MN---LSYSEEEFDVLS-----------------------------------------------------------------------ESAVDFIRTLLVKKPEDRAT------AE-ECLKHPWL--------------
-----------------------------ILT---SKELGRGKFAVV---RQCIS---K-------S-TGQ---EYAA-KFL-KKR-R-RGQ---DC--R-A-EILH-------EIAVLELA-KS------CPR-----VINLHEVYE--N-----------------------------TSEII--LILEY-AAGG--EIFSLCLP------ELAE-------------------------MV---SENDVIRLIKQILEGVYYLHQ--N-----NIVHLDLKPQNILLS---SIYPLG------DIKIVDFGMSRK------------------------IGHACEL---------RE---IMGTPEYLAPEI-LN-----------YDP---ITTATDMWNIGIIAYMLLT-HT-SP---------------FV-GE-------DN-QETYLNISQ----VN---VDYSEETFSSVS-----------------------------------------------------------------------QLATDFIQSLLVKNPEKRPT------AE-ICLSHSWL--------------
--------------------------------FTKLEKIGKGSFGEV---FKGID---N-------R-TQK---VVAI-KII-DLE-E-AED---EI--E-D-IQ-Q-------EITVLSQC--D------SPY-----VTKYYGSYL--K-----------------------------DTKLW--IIMEY-LGGG--SALDLLE---------PG-------------------------PL---DETQIATILREILKGLDYLHS--E-----KKIHRDIKAANVLLS---EHGEV---------KLADFGVAGQL-----------------------TDTQIKR---------NT---FVGTPFWMAPEV-IK-----------QSA---YDSKADIWSLGITAIELAR-GE-PP---------------HS-EL----HPMKV-LFLIPKNNP----PT---LEGNYS-----------------------------------------------------------------------------KPLKEFVEACLNKEPSFRPT------AK-ELLKHKFI--------------
--------------------------------YTFGRILGKGSFGIV---IEATD---K-------E-TET---KWAI-KKV-NKE-K-AGS---SA--V-K-LLER-------EVNILKSV--K------HEH-----IIHLEQVFE--T-----------------------------PKKMY--LVMEL-CEDG--ELKEILD--------RKG-------------------------HF---SENETRWIIQSLASAIAYLHN--N-----DIVHRDLKLENIMVK---SSLIDDNNEINLNIKVTDFGLAVKK----------------------QSRSEAML---------QA---TCGTPIYMAPEV-IS-----------AHD---YSQQCDIWSIGVVMYMLLR-GE-PP---------------FL-AS-------SE-EKLFELIRK----GE---LHFENAVWNSIS-----------------------------------------------------------------------DCAKSVLKQLMKVDPAHRIT------AK-ELLDNQWL--------------
--------------------------------YELQEVIGSGATAVV---QAALC---K-------P-RQE---RVAI-KRI-NLE-K-CQT---SM--D-E--LLK-------EIQAMSQC--S------HPN-----VVTYYTSFV--V-----------------------------KDELW--LVMKL-LSGG--SMLDIIKYIVNRGEHKNG-------------------------VL---EEAIIATILKEVLEGLDYLHR--N-----GQIHRDLKAGNILLG---EDGSV---------QIADFGVSAFLAT------------------GGDVTRNKVR---------KT---FVGTPCWMAPEV-ME----------QVRG---YDFKADMWSFGITAIELAT-GA-AP---------------YH-KY----PPMKV-LMLTLQNDP----PT---LETGVEDKE--MMK------------------------------------------------------------------KYGKSFRKLLSLCLQKDPSKRPT------AA-ELLKCKFF--------------
------------------------------YL--LLHLLGRGGFSEV---YKAFD---L-------Y-EQR---YAAV-KIH-QLN-K-SWR---DE--K-K-ENYHKH--ACREYRIHKEL--D------HPR-----IVKLYDYFS--L----------------------------DTDTFC--TVLEY-CEGN--DLDFYLK--------QHK-------------------------LM---SEKEARSIVMQIVNALRYLNE--IK---PPIIHYDLKPGNILLV---DGTACG------EIKITDFGLSKIMDDD-----------------SYGVDGMDLT---------SQ---GAGTYWYLPPEC-FVV-------GKEPPK---ISNKVDVWSVGVIFFQCLY-GR-KP---------------FG-HN-----QSQQ-DILQENTIL----KA---TEVQFPVKPVVS-----------------------------------------------------------------------SEAKAFIRRCLAYRKEDRFD------VH-QLANDPYL--------------
------------------------------YL--LLHLLGRGGFSEV---YKAFD---L-------T-EQR---YVAV-KIH-QLN-K-NWR---DE--K-K-ENYHKH--ACREYRIHKEL--D------HPR-----IVKLYDYFS--L----------------------------DTDSFC--TVLEY-CEGN--DLDFYLK--------QHK-------------------------LM---SEKEARSIIMQIVNALKYLNE--IK---PPIIHYDLKPGNILLV---NGTACG------EIKITDFGLSKIMDDD----------------SYNSVDGMELT---------SQ---GAGTYWYLPPEC-FVV-------GKEPPK---ISNKVDVWSVGVIFYQCLY-GR-KP---------------FG-HN-----QSQQ-DILQENTIL----KA---TEVQFPPKPVVT-----------------------------------------------------------------------PEAKAFIRRCLAYRKEDRID------VQ-QLACDPYL--------------
---------------------------YLLGI-----NLGEGSYAKV---KSAYS---E-------R-LKF---NVAI-KII-DRK-K-APA---DF--L-E-KFLP------REIEILAML--N------HCS-----IIKTYEIFE--T----------------------------SHGKVY--IVMEL-AVQG--DLLELIK--------TRG-------------------------AL---HEDEARKKFHQLSLAIKYCHD--L-----DVVHRDLKCDNLLLD---KDFNI---------KLSDFSFSKRCLR-------------------DDSGRMALS---------KT---FCGSPAYAAPEV-LQ----------GIPY---QPKVYDIWSLGVILYIMVC-GS-MP---------------YD-DS-------NI-KKMLRIQKE----HR---VNFPRSKHLT-------------------------------------------------------------------------GECKDLIYHMLQPDVNRRLH------ID-EILSHCWM--------------
--------------------------------YSILKQIGSGGSSKV---FQVLN---E-------K-KQ----IYAI-KYV-NLE-E-ADN---QT--L-D-SYRN-------EIAYLNKL-QQ-----HSDK-----IIRLYDYEI--T-----------------------------DQYIY--MVMEC-GNI---DLNSWLK--------KKK-------------------------SI---DPWERKSYWKNMLEAVHTIHQ--H-----GIVHSDLKPANFLIV----DGML---------KLIDFGIANQMQ---------------------PDTTSVVK---------DS---QVGTVNYMPPEA-IKDMSSSRENGKSKSK---ISPKSDVWSLGCILYYMTY-GK-TP---------------FQ-QI------INQ-ISKLHAIID----PN---HEIEFPDIPE-------------------------------------------------------------------------KDLQDVLKCCLKRDPKQRIS------IP-ELLAHPYV--------------
-------------------------------L-AFIKEIGSGQFGVV---HLGEW---R---------SHI---QVAI-KAI-N-E-G-SM----SE--E-D-FI-E-------EAKVMMKL--S------HSK-----LVQLYGVCI--Q-----------------------------RKPLY--IVTEF-MENG--CLLNYLR---------EN-----------------------KGKL---RKEMLLSVCQDICEGMEYLER--N-----GYIHRDLAARNCLVS---STCIV---------KISDFGMTRYV-----------------------L--DDEY---------VSSFGAKFPIKWSPPEV-FL-----------FNK---YSSKSDVWSFGVLMWEVFTEGK-MP---------------FE-NK----SNLQV-VEAISEGFR----LY---RPHLAP-----------------------------------------------------------------------------MSIYEVMYSCWHEKPEGRPT------FA-ELLR---AV-------------
------------------------------FS--RKDLIGHGAFAVV---FKGRH---R-------E-KHD--LEVAV-KCI-NKK-N-LAK---SQ--T---LLGK-------EIKILKEL--K------HEN-----IVALYDFQE--M-----------------------------ANSVY--LVMEY-CNGG--DLADYLH--------AMR-------------------------TL---SEDTIRLFLQQIAGAMRLLHS--K-----GIIHRDLKPQNILLS---NPAGRRANPNSIRVKIADFGFARY------------------------LQSNMMA---------AT---LCGSPMYMAPEV-IM-----------SQH---YDGKADLWSIGTIVYQCLT-GK-AP---------------FQ-AS----SPQDL-RLFYEKNKT----LV---PTIPRETS---------------------------------------------------------------------------APLRQLLLALLQRNHKDRMD------FD-EFFHHPFL--------------
-------------------------------Y-SKRDLVGHGAFAVV---FRGRH---R-------Q-KTD--WEVAI-KSI-NKK-N-LSK---SQ----I-LLGK-------EIKILKEL--Q------HEN-----IVALYDVQE--L-----------------------------PNSVF--LVMEY-CNGG--DLADYLQ--------AKG-------------------------TL---SEDTIRVFLHQIAAAMRILHS--K-----GIIHRDLKPQNILLS---YANRRKSSVSGIRIKIADFGFARY------------------------LHSNMMA---------AT---LCGSPMYMAPEV-IM-----------SQH---YDAKADLWSIGTVIYQCLV-GK-PP---------------FQ-AN----SPQDL-RMFYEKNRS---------LMPSIPRETS-------------------------------------------------------------------------PYLANLLLGLLQRNQKDRMD------FE-AFFSHPFL--------------
------------------------------FI--LTERLGSGTYATV---YKAYA---KK------D-TRE---VVAI-KCV-AKK-S-LNK---AS--V-E-NLLT-------EIEILKGI--R------HPH-----IVQLKDFQW--D-----------------------------SDNIY--LIMEF-CAGG--DLSRFIH--------TRR-------------------------IL---PEKVARVFMQQLASALQFLHE--R-----NISHLDLKPQNILLSS-LEKPHL---------KLADFGFAQH------------------------MSPWDEK---------HV---LRGSPLYMAPEM-VC-----------QRQ---YDARVDLWSMGVILYEALF-GQ-PP---------------FA-SR----SFSEL-EEKIRSNRV----IE---LPLRPLLS---------------------------------------------------------------------------RDCRDLLQRLLERDPSRRIS------FQ-DFFAHPWV--------------
--------------------------------WTKGEILGKGAYGTV---YCGLT---S-------Q-GQ----LIAV-KQV-ALD-T-SNK---LA--A-E-KEYRKL---QEEVDLLKAL--K------HVN-----IVAYLGTCL--Q-----------------------------ENTVS--IFMEF-VPGG--SISSIIN--------RFG-------------------------PL---PEMVFCKYTKQILQGVAYLHE--N-----CVVHRDIKGNNVMLM---PTGII---------KLIDFGCARRLAWA-----------------GLNGTHSDML---------KS---MHGTPYWMAPEV-IN-----------ESG---YGRKSDIWSIGCTVFEMAT-GK-PP---------------LA-SM------DRM-AAMFYIGAH----RG---LMPPLPDHFS-------------------------------------------------------------------------ENAADFVRMCLTRDQHERPS------AL-QLLKHSFL--------------
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